CN202379915U - Hydroxyethyl starch refining device - Google Patents
Hydroxyethyl starch refining device Download PDFInfo
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- CN202379915U CN202379915U CN2012201346709U CN201220134670U CN202379915U CN 202379915 U CN202379915 U CN 202379915U CN 2012201346709 U CN2012201346709 U CN 2012201346709U CN 201220134670 U CN201220134670 U CN 201220134670U CN 202379915 U CN202379915 U CN 202379915U
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- accurate filter
- connecting tube
- storage tank
- valve
- feed
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Abstract
Provided is a hydroxyethyl starch refining device. An ultrafiltration membrane assembly is utilized to separate ultrafiltration membranes of hydroxyethyl starch feed liquid, and a rejected water outlet of the ultrafiltration membrane assembly is connected with a feed liquid inlet of a frame filter through a pipeline. During the separation of the ultrafiltration membranes of the hydroxyethyl starch, excessive pressure of ultrafiltration membrane rejected water is utilized to enable the feed liquid to be micro-filtered through a precision filter. Therefore, the energy utilization rate is improved, and the quantity of microorganism of the feed liquid in the process of ultrafiltration membrane separation can be effectively controlled.
Description
Technical field
The utility model belongs to chemical field; Relate to the hydroxyethylamyle purification apparatus; Be specifically related to be used for hydroxyethylamyle process for refining process to hydroxyethyl starch solution in mikrobe, inorganics particulate, residual impurity content control and purification apparatus that can effective use of energy sources.
Background technology
Hydroxyethylamyle is through hydrochloric acid hydrolysis, hydroxyethylation, decolouring, refining forming by starch.In hydrochloric acid hydrolysis, hydroxyethylation process, can produce sodium-chlor, terepthaloyl moietie, glycol chlorohydrin residual impurity; In decolorization, can add Medicinal Charcoal.In treating process, must remove the mikrobe that grows in micro activated carbon particle and the production process in the hydroxyethylamyle destainer through micro-filtration; Make turbidity, bacterial endotoxin reach requirement, the hydroxyethylamyle registered standard regulation turbidity that issues like State Food and Drug Administration must not be deeper than turbidity liquid No. 1; Separate that through ultra-filtration membrane hydroxyethylamyle residual impurity content is reduced to prescribed level, the hydroxyethylamyle registered standard regulation sodium chloride content that issues like State Food and Drug Administration must not cross 0.5%, terepthaloyl moietie must not cross 0.062%, glycol chlorohydrin must not cross 0.0020%.Existing hydroxyethylamyle purification apparatus is to be in series by accurate filter and ultra-filtration membrane separation system.The hydroxyethylamyle destainer pressurizes through infusion pump, filters through accurate filter, gets into storage tank; After treating that feed liquid is all filtered through accurate filter, close hydroxyethylamyle destainer opening for feed, open the ultra-filtration membrane separation system; In storage tank, add purified water; The speed that adds purified water equals ultra-filtration membrane separates through the effusive speed of liquid, makes the interior material liquid volume of storage tank keep constant, sees through fluid power and constantly takes small molecules residual impurity in the feed liquid out of; Treat that residual impurity content is reduced to prescribed level, stops treating process.Degerming, clarifying purpose can be reached through micro-filtration, the purpose of control residual impurity can be reached through the ultra-filtration membrane separation system.There is following shortcoming in existing hydroxyethylamyle purification apparatus: 1. micro-filtration can only be removed the mikrobe that the accurate filter front end produces; And can not remove the mikrobe that in the ultra-filtration membrane sepn process, possibly newly grow; Feed liquid is bigger by the risk of microbial contamination, and quality product is had disadvantageous effect.2. some hyperfiltration membrane assembly reaches 1.2Mpa like the rolled membrane module WP, and feed liquid still can reach more than the 0.5Mpa through behind the hyperfiltration membrane assembly, directly is back in the storage tank by dense waterpipe, wastes the energy.
Summary of the invention
The utility model provides a kind of hydroxyethylamyle purification apparatus, make its have can be in ultra-filtration membrane partitioning cycle process controlling microbial quantity, and can effectively utilize the hydroxyethylamyle purification apparatus of the dense water overbottom pressure of ultra-filtration membrane.
The technical scheme that realizes the utility model is:
This hydroxyethylamyle purification apparatus that the utility model provides; Comprise storage tank 6, ultrafiltrate pump 9, hyperfiltration membrane assembly 13, accurate filter 3; The feed end of accurate filter 3 is connected with feed pipe 2; This feed pipe 2 is provided with feed valve 1, on accurate filter 3, also is provided with accurate filter tensimeter 4, is connected through connecting tube 5 between the top fed mouth of the discharge port of accurate filter 3 and storage tank 6; Be connected through connecting tube 8 between storage tank discharge port and ultra-filtration membrane membrane module 13 opening for feeds; This connecting tube 8 is provided with storage tank bottom valve 7, ultrafiltrate pump 9, under meter 10, flowrate control valve 11 and defeated material tensimeter 12, and the discharge end of hyperfiltration membrane assembly 13 is divided into dense waterpipe 15 and sees through liquid pipeline 14, is connected through connecting tube 18 between the top fed mouth of the other end of dense waterpipe 15 and storage tank 6; Dense waterpipe 15 is provided with dense water pressure table 16, mould variable valve 17; Connecting tube 18 is provided with concentrate recirculation valve 19, and the other end that sees through liquid pipeline 14 links to each other with the external world, it is characterized in that: between the feed pipe 2 of dense waterpipe 15 and accurate filter 3, be provided with connecting tube 20.Shut off valve 21 and/or force (forcing) pump 24 can also be set on connecting tube 20.
Existing hydroxyethylamyle purification apparatus is to be in series by accurate filter and ultra-filtration membrane separation system.The hydroxyethylamyle destainer pressurizes through infusion pump, filters through accurate filter 3, gets into storage tank 6; After treating that feed liquid is all filtered through accurate filter 3, close hydroxyethylamyle destainer opening for feed, open the ultra-filtration membrane separation system; In storage tank 6, add purified water; The speed that adds purified water equals ultra-filtration membrane separates through the effusive speed of liquid, makes the interior material liquid volume of storage tank keep constant, sees through fluid power and constantly takes small molecules residual impurity in the feed liquid out of; Treat that residual impurity content is reduced to prescribed level, stops treating process.Degerming, clarifying purpose can be reached through micro-filtration, the purpose of control residual impurity can be reached through the ultra-filtration membrane separation system.
The improvement part of the utility model is: between the feed pipe 2 of dense waterpipe 15 and accurate filter 3, connecting tube 20 is set, shut off valve 21 and/or force (forcing) pump 24 can also further be set on connecting tube 20.
Its working process is: feed liquid gets into storage tank through accurate filter earlier, and the feed liquid in the storage tank is pressurizeed by ultrafiltrate pump, through hyperfiltration membrane assembly; Be divided into dense water and see through liquid, utilize the overbottom pressure of dense water, make dense water through the smart filter of accurate filter; Get into storage tank once more, constitute the self-circulation system of operation continuously.
The beneficial effect of the utility model is:
1. utilized the overbottom pressure of the dense water of ultra-filtration membrane, effective use of energy sources.
2. make feed liquid smart repeatedly filter in ultra-filtration membrane partitioning cycle process, control the level of mikrobe in the feed liquid, reduce the risk of microbial contamination, reduce endotoxic content in the feed liquid.
The hydroxyethylamyle purification apparatus that the utility model provides; Mikrobe, inorganics particulate, residual impurity content are controlled in can be to hydroxyethyl starch solution in hydroxyethylamyle process for refining process; Product purification feed liquid quality is improved, and can effective use of energy sources.
Description of drawings
Below in conjunction with accompanying drawing and embodiment the utility model is further specified.
Fig. 1 is the structure iron of an embodiment of the utility model.
Fig. 2 is the equipment structure chart of the dense water pressure of the hyperfiltration membrane assembly that uses of the utility model when not reaching the WP of accurate filter.
Part shown in the Digital ID is in the accompanying drawing:
1, feed valve
2, the feed pipe of accurate filter 3
3, accurate filter
4, accurate filter tensimeter
5, the connecting tube between accurate filter discharge port and the storage tank opening for feed
6, storage tank
7, storage tank bottom valve
8, the connecting tube between storage tank discharge port and the ultra-filtration membrane opening for feed
9, ultrafiltrate pump
10, under meter
11, flowrate control valve
12, defeated material tensimeter
13, hyperfiltration membrane assembly
14, see through the liquid pipeline
15, concentrate pipeline
16, dense water pressure table
17, mould variable valve
18, concentrate recirculation pipeline
19, concentrate recirculation valve
20, the connecting tube between dense waterpipe 15 and accurate filter 3 feeding mouths
21, shut off valve
22, purified water pipeline
23, purified water flowrate control valve
24, force (forcing) pump.
Embodiment
As shown in Figure 1; This hydroxyethylamyle purification apparatus comprises storage tank 6, ultrafiltrate pump 9, hyperfiltration membrane assembly 13, accurate filter 3; The feed end of accurate filter 3 is connected with feed pipe 2, and this feed pipe 2 is provided with feed valve 1, on accurate filter 3, also is provided with accurate filter tensimeter 4; Be connected through connecting tube 5 between the top fed mouth of the discharge port of accurate filter 3 and storage tank 6; Be connected through connecting tube 8 between storage tank discharge port and ultra-filtration membrane membrane module 13 opening for feeds, this connecting tube 8 is provided with storage tank bottom valve 7, ultrafiltrate pump 9, under meter 10, flowrate control valve 11 and defeated material tensimeter 12, and the discharge end of hyperfiltration membrane assembly 13 is divided into dense waterpipe 15 and sees through liquid pipeline 14; Be connected through connecting tube 18 between the top fed mouth of the other end of dense waterpipe 15 and storage tank 6; Dense waterpipe 15 is provided with dense water pressure table 16, mould variable valve 17, and connecting tube 18 is provided with concentrate recirculation valve 19, and the other end that sees through liquid pipeline 14 links to each other with the external world; Between the feed pipe 2 of dense waterpipe 15 and accurate filter 3, be provided with connecting tube 20, shut off valve 21 is set on connecting tube 20.
The present embodiment improvements over the prior art partly are: with being connected with pipeline 20 between dense water out pipeline 15 and the accurate filter 3 feed liquids inlet, its working process is: feed liquid gets into storage tanks 6 through accurate filter 3 earlier, and the feed liquid in the storage tank 6 is pressurizeed by ultrafiltrate pump 9; Through hyperfiltration membrane assembly 13; Be divided into dense water and see through liquid, utilize the overbottom pressure of dense water, make dense water through accurate filter 3 smart filters; Get into storage tank 6 once more, constitute the self-circulation system of operation continuously.During use, concrete operation method is following: half-open feed valve 1, close storage tank bottom valve 7, trapped line pressure valve 21; The hydroxyethylamyle destainer is pressurizeed by infusion pump; Filter through accurate filter 3, get into storage tank 6, adjustment feed valve 1; Make accurate filter tensimeter 4 be shown 0.35Mpa, all get into storage tank 6 to feed liquid.Close feed valve 1; Open storage tank bottom valve 7, flowrate control valve 11, mould variable valve 17, concentrate recirculation valve 19, shut off valve 21 successively; Open ultrafiltrate pump 9, adjustment flowrate control valve 11, mould variable valve 17, making defeated material tensimeter 12 registrations is that 0.8～0.9Mpa, under meter 10 registrations are 12～14m
3/ h, feed liquid, is divided into dense water and sees through liquid through rolling hyperfiltration membrane assembly 13 through pressurization, and dense water gets into dense waterpipe 15, sees through liquid pipeline 14 through the liquid entering and discharges.This moment, dense water pressure table 16 registration was 0.5～0.7Mpa; It is 0.3～0.4Mpa that adjustment concentrate recirculation valve 19 makes accurate filter tensimeter 4 registrations; Opening purified water flowrate control valve (23) adding purified water keeps storage tank 6 interior material liquid volumes constant; Be reduced to prescribed level to residual impurity content, close purified water flowrate control valve 23, ultrafiltrate pump 9, stop treating process.
Get hydroxyethylamyle purification apparatus purified feed liquid among the embodiment 1; By " 2 appendix IX of Chinese pharmacopoeia version in 2010 B clarity test procedure, XI E bacterial endotoxins test, XI J limit test of microbe method; Its turbidity, bacterial endotoxin, microbial limit are tested, and the result is following:
Bacterial endotoxin: bacteria endotoxin content is lower than 2.5EU/ml
Microbial limit: 0/ml
Turbidity: less than No. 1 turbidity liquid
Before purification apparatus was transformed, certain used the identical initial feed liquid of complete processing, and after refining, its bacterial endotoxin, microbial limit, turbidity, content are respectively:
Bacterial endotoxin: bacteria endotoxin content surpasses 10EU/ml
Microbial limit: 9/ml
Turbidity: greater than No. 1 turbidity liquid, less than No. 2 turbidity liquid
Visible by above assay, the hydroxyethylamyle purification apparatus can effectively be controlled bacterial endotoxin, microbial limit, turbidity after the improvement that the utility model provides, and product purification feed liquid quality is improved.
As shown in Figure 2, this hydroxyethylamyle purification apparatus is on connecting tube 20, to be provided with force (forcing) pump 24 on the basis of embodiment 1.When dense water pressure during less than the WP of accurate filter, can be as shown in Figure 2, on the connecting tube between dense waterpipe and the plate filter feeding mouth, add force (forcing) pump 25.Working method with embodiment 1 to " ... adjustment flowrate control valve 11, mould variable valve 16 "; Making defeated material tensimeter 12 registrations is 0.08Mpa; Feed liquid is passed through polysulfone hollow fiber ultrafiltration membrane system 13 through pressurization; Be divided into dense water and see through liquid, dense water gets into dense waterpipe 15, sees through liquid and gets into through 14 discharges of liquid pipeline.This moment dense water pressure table 16 registration 0.02Mpa, less than the WP 0.3Mpa of accurate filter.Open force (forcing) pump 24, regulate trapped line pressure valve 21, make dense water pressure reach 0.3～0.4Mpa, after this operate with embodiment 1 and " open purified water flowrate control valve 23...... ".
Embodiment 4
Get hydroxyethylamyle purification apparatus purified feed liquid among the embodiment 3; By " 2 appendix IX of Chinese pharmacopoeia version in 2010 B clarity test procedure, XI E bacterial endotoxins test, XI J limit test of microbe method; Its turbidity, bacterial endotoxin, microbial limit are tested, and the result is following:
Bacterial endotoxin: bacteria endotoxin content is lower than 2.5EU/ml
Microbial limit: 0/ml
Turbidity: less than No. 1 turbidity liquid
Visible by above assay, gained feed liquid among embodiment 3 and the embodiment 1, turbidity, bacterial endotoxin, microbial limit assay are similar, be superior to existing equipment the level of refining feed liquid.
Claims (3)
1. a hydroxyethylamyle purification apparatus comprises storage tank (6), ultrafiltrate pump (9), hyperfiltration membrane assembly (13), accurate filter (3)
,The feed end of accurate filter (3) is connected with feed pipe (2), and this feed pipe (2) is provided with feed valve (1),
Also be provided with accurate filter tensimeter (4) on the accurate filter (3); Be connected through connecting tube (5) between the top fed mouth of the discharge port of accurate filter (3) and storage tank (6); (8 are connected through connecting tube between storage tank discharge port and ultra-filtration membrane membrane module (13) opening for feed; This connecting tube (8) is provided with storage tank bottom valve (7), ultrafiltrate pump (9), under meter (10), flowrate control valve (11) and defeated material tensimeter (12); The discharge end of hyperfiltration membrane assembly (13) is divided into dense waterpipe (15) and sees through liquid pipeline (14); Be connected through connecting tube (18) between the top fed mouth of the other end of dense waterpipe (15) and storage tank (6); Dense waterpipe (15) is provided with dense water pressure table (16), mould variable valve (17); Connecting tube (18) is provided with concentrate recirculation valve (19), and the other end that sees through liquid pipeline (14) links to each other with the external world, it is characterized in that: between the feed pipe (2) of dense waterpipe (15) and accurate filter (3), be provided with connecting tube (20).
2. hydroxyethylamyle purification apparatus according to claim 1 is characterized in that, is positioned at that connecting tube (20) is provided with shut off valve (21) between the feed pipe (2) of dense waterpipe (15) and accurate filter (3).
3. hydroxyethylamyle purification apparatus according to claim 1 and 2 is characterized in that, the connecting tube (20) that is positioned between the feed pipe (2) of dense waterpipe (15) and accurate filter (3) is provided with force (forcing) pump (24).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012201346709U CN202379915U (en) | 2012-04-01 | 2012-04-01 | Hydroxyethyl starch refining device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012201346709U CN202379915U (en) | 2012-04-01 | 2012-04-01 | Hydroxyethyl starch refining device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202379915U true CN202379915U (en) | 2012-08-15 |
Family
ID=46628433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012201346709U Expired - Lifetime CN202379915U (en) | 2012-04-01 | 2012-04-01 | Hydroxyethyl starch refining device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202379915U (en) |
-
2012
- 2012-04-01 CN CN2012201346709U patent/CN202379915U/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20120815 |