CN200987711Y - Artificial biological pulmonary artery and valve canal - Google Patents

Artificial biological pulmonary artery and valve canal Download PDF

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Publication number
CN200987711Y
CN200987711Y CN 200620175187 CN200620175187U CN200987711Y CN 200987711 Y CN200987711 Y CN 200987711Y CN 200620175187 CN200620175187 CN 200620175187 CN 200620175187 U CN200620175187 U CN 200620175187U CN 200987711 Y CN200987711 Y CN 200987711Y
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bovine
jugular vein
conduit
bovine jugular
pulmonary
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CN 200620175187
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Chinese (zh)
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金磊
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金磊
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Abstract

The utility model discloses an artificial biological pulmonary arterial valved conduit, including a section bovine jugular vein vessel with venous valve, one or two pipes made of the bovine pericardial tissue material are connected to the upper end or both ends of the bovine jugular vein vessel, the external surface of the artificial biological pulmonary arterial valved conduit is coated with a polymer materials layer. The utility model only adopts a section of bovine jugular vein valved conduit, the upper end or both ends are replaced by the biological pipe made of bovine pericardium, at the same time the polymer materials layer is coated on the external surface of pipe, thus can settle the problems in that, only using the bovine jugular vein tissue, the pipe valvular inadequacy results from over strong reaction, severe calcification and easy expansion, and the problem in over adhesion in secondary operation, the long term curative effect can be improved greatly.

Description

人工生物肺动脉带瓣管道 Pulmonary valved conduit bioprosthetic

技术领域 FIELD

本实用新型涉及一种新型人工生物肺动脉带瓣管道,特别涉及用于重建人右心室-肺动脉连接的人工生物肺动脉带瓣管道。 The present invention relates to a novel bio-artificial pulmonary valved conduit, particularly to a human for reconstructing the right ventricle - pulmonary bioprosthetic valved conduit connected to the pulmonary artery.

背景技术 Background technique

许多复杂先天性心脏疾病,如法洛四联症、肺动脉闭锁、右室双出口等以及主动脉病变行Ross手术者,均需重建右室-肺动脉连接,常用的材料有自体心包、异种材料、同种异体主动脉带瓣管道、人工材料如Gore-tex片、人工合成的带瓣管道.这些材料均存在局限性,Gore-tex片一般不能重建瓣膜结构;自体心包构造带瓣的结构,效果不理想;由于右心系统压力低,血流速度慢,人工瓣膜特别是机械瓣置入之后血栓栓塞并发症多,尤其是内径较小的人工管道远期效果欠佳。 Many complex congenital heart disease, such as tetralogy of Fallot, pulmonary atresia, double outlet right ventricle, and aortic diseases like rows Ross surgery, right ventricular reconstruction required - pulmonary artery connection, materials commonly used autologous pericardium, dissimilar materials, . allograft aortic valved conduit, an artificial material such as Gore-tex sheet, synthetic materials are valved conduit these limitations, Gore-tex sheet generally can not be reconstructed valve structure; from pericardial lobes configured with a structure, the effect of not ideal; low-pressure system since the right heart, the blood flow is slow, especially after mechanical prosthetic valve implantation valve thromboembolic complications, especially poor smaller inner diameter pipe artificial long-term effects.

近几年,临床应用牛颈静脉带瓣管道(BJVC)重建肺动脉与右室连接,牛颈静脉带有静脉瓣,具有天然的瓣膜结构,可以防止舒张期的血液返流,手术初期效果较为理想。 In recent years, the clinical application of bovine jugular vein conduit (BJVC) chamber connected to the right pulmonary artery reconstruction, bovine jugular vein with venous valve, having a natural valve structure can be prevented diastolic blood regurgitation, it is preferable that the initial effect of surgery . 但随着对术后病人的随访,由于牛颈静脉血管壁组织异种组织反应强,并且静脉瓣上端一段牛静脉血管内径渐小,因此在植入后一旦发生与肺动脉吻合口处组织增生反应,时有再度导致右室流出道狭窄。 However, with the follow-up of postoperative patients, bovine jugular vein wall tissue due to the strong xenogeneic tissue reaction, and the upper end section of venous valve bovine vein vessel diameter gradually small, so after implantation event and pulmonary artery anastomosis tissue proliferative response, when there is once again leading to right ventricular outflow tract obstruction. 致使病人不得不面临二次手术的风险。 Causing the patient had to face the risk of reoperation. 同时,我们实验研究发现,尽管采用同样的化学改性处理和有效的抗钙化处理,植入体内的牛静脉血管壁组织仍表现出比同一牛静脉瓣组织或牛心包组织更易发生钙化,尤其是在年幼动物表现的有为明显。 At the same time, we Experimental study found that despite using the same chemical modification and effective anti-calcification treatment, implanted in the body wall tissue of cattle blood still showed calcification more than the same cow or bovine pericardial tissue valve intravenous organizations, in particular in young animals promising performance significantly. 此外,由于牛颈静脉壁抗张强度较牛心包组织更为薄弱,当肺动脉压力升高时,常有发生颈静脉壁过度扩张而导致静脉瓣关闭不全。 In addition, due to the bovine jugular vein wall tensile strength than the bovine pericardial tissue is more weak, when the pulmonary artery pressure, often occur jugular venous wall caused by over-expansion valve regurgitation. 因此,由于上述多种原因使牛颈静脉带瓣管道的临床应用受到限制,至今尚无理想的用于右室流出道植换治疗用带瓣管道代用产品。 Accordingly, since the various reasons clinical applications of bovine jugular vein conduit is limited, so far no ideal explants for RVOT transducer therapeutic alternative valved conduit products.

实用新型内容本实用新型所要解决的技术问题是提供一种人工生物肺动脉带瓣管道,仅采用牛颈静脉带瓣部分管道,其上端或两端以牛心包制成的生物管道取而代之,同时在管道外表面加覆医用高分子材料层可以很好地以上述及的问题,可极大改善其远期使用的效果。 SUMMARY The present invention is to solve the technical problem of providing a bioprosthetic pulmonary valved conduit, using only part of bovine jugular vein conduit, the biological conduit in its upper end or both ends instead made of bovine pericardium, while the pipe increase to cover the outer surface of the problem of medical polymer materials can be well layer mentioned above, can greatly improve the effectiveness of their long-term use.

为解决上述技术问题,本实用新型所采取的技术方案是:一种人工生物肺动脉带瓣管道,包括一段带有静脉瓣的牛颈静脉血管,一个或两个牛心包组织材料制成的管道连接在所述牛颈静脉血管的上端或上、下两端,所述人工生物肺动脉带瓣管道外表面被覆高分子材料层。 To solve the above problems, the present invention is adopted technical solution: an artificial biological pulmonary valved conduit, comprising a bovine jugular vein with venous valve section, or a pipe made of bovine pericardial tissue material connecting two at the upper end of the bovine jugular vein or the upper and lower ends, said polymeric material of the surface coating layer of bioprosthetic valved pulmonary outer tube.

其中,所述牛颈静脉血管长2.5-6.5cm、内径为10.0-22.0mm,牛颈静脉血管内具有至少一组瓣叶厚度均匀、形状大小一致、对称、闭合良好的两叶或三叶颈静脉瓣;所述连接在牛颈静脉血管上端的牛心包管道长度为3.5-6.5cm,所述牛颈静脉血管内静脉瓣下缘距离肺动脉带瓣管道下端一段牛颈静脉血管的长度为3.5-6.5cm或连接牛颈静脉血管内静脉瓣下缘的牛心包管道长度为3.5-6.5cm;所述牛心包组织材料和牛颈静脉血管经化学改性处理;所述化学改性处理方法包括用生理盐水或各类组织等渗溶液对新鲜牛颈静脉管组织的漂洗、用浓度为0.3-2.5戊二醛溶液固定2小时以上或用表面活性剂或配位化合物或环氧化合物进行抗钙化处理;所用牛心包组织材料制成的管道接头内径与带瓣牛颈静脉管内径相同;所述高分子材料层为聚酯织物或聚酯无纺膜布,所述高分子材料层上带 Wherein the bovine jugular vein long 2.5-6.5cm, an inner diameter of 10.0-22.0mm, bovine jugular vein at least one set having a uniform thickness of the leaflet, uniform shape and size, symmetrical, well-closed two-leaf clover or neck venous valves; connecting the upper end of the bovine pericardium bovine jugular vein conduit length 3.5-6.5cm, the length from the edge of the lower end of the pipe section pulmonary valved bovine jugular vein in the vein of the bovine jugular vein lobes 3.5 6.5cm bovine pericardium or lower edge of the pipe endovascular venous valve connection length bovine jugular vein of 3.5-6.5cm; the bovine pericardial tissue and bovine jugular vein material by chemical modification; said method comprising chemical modification treatment with physiological an isotonic saline solution or rinsing of all types of tissue fresh bovine jugular vein tissue tube, using a fixed concentration of 0.3 to 2.5 glutaraldehyde solution for two hours or more or with a surfactant or a coordination compound or an epoxy compound anticalcification process; diameter of the pipe joint used bovine pericardial tissue material with valved bovine jugular vein same inner diameter; said polymer material layer is a non-woven polyester fabric or polyester fabric film with said polymer material layer 有标志线。 There are signs line.

本实用新型所能达到的有益效果是:1.合理、巧妙的结构设计,既利用了牛颈静脉的瓣膜,又极大改善了原来全牛颈静脉管道生物相容性欠佳、易发生钙化的弊端;2.牛心包制成的连接管道具有良好的生物相容性,与人体肺动脉端缝合在一起避免了由于较强的组织增生反应导致吻合口再度狭窄;3.结构设计合理,使管道上、下端尺寸即满足了解剖结构和生理功能的需要,又便于心外科医生手术操作方便,减少手术操作的时间,显著降低了可能发生的各类相关并发症;4.外表面被覆高分子材料层,即可防止由于肺动脉压力升高而发生管壁过度扩张、瓣膜关闭,又可有效避免管道外壁与人体组织过度粘连,使再次手术便于操作。 The utility model can achieve beneficial effects: 1. reasonable, clever structural design, both the use of bovine jugular vein valve, but also greatly improved the original full-bovine jugular vein conduit poor biocompatibility, prone to calcification drawbacks; 2 connecting duct made of bovine pericardium has good biocompatibility with human pulmonary artery sewn together end avoids strong proliferative response resulting in tissue again anastomotic stenosis; 3 structure design, the pipe upper and lower end i.e. the size meets the needs of the anatomy and physiological function, cardiac surgeon and facilitates ease of operation, reduced surgical procedure time, significantly reduces the possible complications related to various types; 4 covering the outer surface of the polymer material layer can prevent the occurrence of pulmonary artery pressure and excessive expansion of the wall, the valve is closed, but also avoid excessive pipe wall with human tissue adhesion, easy to operate the surgical again.

附图说明 BRIEF DESCRIPTION

图1为本实用新型实施例1结构示意图;图2为本实用新型实施例2结构示意图;图3为本实用新型实施例3结构示意图。 1 FIG. 1 is a schematic structure of a new embodiment of the disclosure; 2 structural diagram of invention Example 2 of the present embodiment; 3 a schematic structure of a new embodiment of Figure 3 the present invention.

具体实施方式 detailed description

实施例1参阅图1,为本实用新型实施例1人工生物肺动脉带瓣管道结构示意图,包括具有瓣膜的牛颈静脉制备的带瓣管道3,和两片牛心包材料制备的连接管道1、2,连接管道1、2于瓣膜上端将带瓣管道3夹于中间,并用缝线缝合在一起,整个管道外包覆一层高分子材料层4。 Connecting pipes 3, and prepared according to Example 1 Referring to Figure 1, a schematic view of a bioprosthetic pulmonary conduit with valves novel embodiment of the disclosure, including the preparation of the valved conduit having a bovine jugular vein bovine pericardial valves two materials 1 connected to the upper end of the valve pipe 2 to valved conduit 3 sandwiched therebetween, and stitched together with sutures, the entire outer layer of the pipe coated with high molecular material layer 4.

实施例2参阅图2,为本实用新型实施例2结构示意图,包括具有瓣膜5的牛颈静脉制备的带瓣管道3,和一牛心包材料制备的连接管道2,连接管道2于瓣膜5上端与带瓣管道3用缝线缝合在一起。 Example 2 Referring to Figure 2, a schematic structure of a new 2 embodiment of the disclosure, including a valved conduit bovine jugular vein valve 5 Preparation of 3, and a connecting duct made of bovine pericardium material 2, the connection pipe 2 to the upper end of the valve 5 and conduit with valves 3 are stitched together with sutures.

实施例3参阅图3,为本实用新型实施例3结构示意图,包括具有瓣膜的牛颈静脉制备的带瓣管道3',和两片牛心包材料制备的连接管道1'、2,连接管道1'、2位于带瓣管道3'两端,并分别通过缝线缝合在一起,牛颈静脉瓣处外表面包覆一层高分子材料6,高分子材料层上标记有指示标志,方便医生手术时迅速分辨位置。 Example 3 Referring to Figure 3, the new structural schematic diagram of Embodiment 3 practical embodiment, comprising a conduit with valves produced bovine jugular vein with a valve 3 ', and two connecting pipes made of bovine pericardium material 1', 2, a connecting pipe ', valved conduit 2 located 3' ends, respectively, and stitched together by a suture, the outer surface of the bovine jugular vein valve polymer material coated with a layer 6, marked with signs on the polymer material layer to facilitate the surgeon when the position quickly resolved.

上述各实施例中,牛心包和牛颈静脉均经过改性处理,方法包括用生理盐水或各类组织渗溶液对新鲜牛颈静脉管组织的漂洗、用浓度为0.3-2.5戊二醛溶液固定2小时以上或用表面活性剂或配位化合物或环氧化合物进行抗钙化处理。 Each of the above embodiments, and bovine pericardium have bovine jugular vein after modification, the method comprising rinsing tube of fresh bovine jugular vein tissue infiltration with saline solution or various types of tissue, with a fixed concentration of 0.3 to 2.5 glutaraldehyde solution 2 hours or more anti-calcification treatment with a surfactant or a coordination compound or an epoxy compound.

各实施例中,牛颈静脉血管长2.5-6.5cm、内径为10.0-22.0mm,连接在牛颈静脉血管上端的牛心包管道长度为3.5-6.5cm,所述牛颈静脉血管内静脉瓣下缘距离肺动脉带瓣管道下端一段牛颈静脉血管的长度为3.5-6.5cm或连接牛颈静脉血管内静脉瓣下缘的牛心包管道长度为3.5-6.5cm。 In various embodiments, bovine jugular vein long 2.5-6.5cm, an inner diameter of 10.0-22.0mm, bovine pericardium length of the pipe connecting the bovine jugular vein of the upper end of 3.5-6.5cm, under the bovine jugular vein within a venous valve length from the lower edge of some pulmonary valved conduit bovine jugular vein or bovine pericardium is 3.5-6.5cm lower edge of the pipe endovascular venous valve bovine jugular vein was connected to a length of 3.5-6.5cm.

以上所述,仅为本发明的较佳实施例而已,并非用于限定本发明的保护范围。 The above are only preferred embodiments of the present invention but are not intended to limit the scope of the present invention.

Claims (7)

  1. 1.一种人工生物肺动脉带瓣管道,包括一段带有静脉瓣的牛颈静脉血管,其特征在于,一个或两个牛心包组织材料制成的生物管道连接在所述牛颈静脉血管的上端或上、下两端,所述人工生物肺动脉带瓣管道整个外表面或静脉瓣处外表面被覆高分子材料层。 A biological artificial pulmonary valved conduit, comprising a bovine jugular vein with venous valve section, wherein the biological conduit made of a material or two bovine pericardial tissue attached to an upper end of said bovine jugular vein or the upper and lower ends, an outer surface coating layer of a polymer material of the bioprosthetic pulmonary valved conduit or the entire outer surface of the venous valves.
  2. 2.根据权利要求1所述的人工生物肺动脉带瓣管道,其特征在于,所述牛颈静脉血管长2.5-6.5cm、内径为10.0-22.0mm,牛颈静脉血管内具有至少一组瓣叶厚度均匀、形状大小一致、对称、闭合良好的两叶或三叶颈静脉瓣。 The bio-artificial pulmonary conduit with valves according to claim 1, wherein the bovine jugular vein long 2.5-6.5cm, an inner diameter of 10.0-22.0mm, having at least one set leaflet bovine jugular vein uniform thickness, uniform shape and size, symmetrical, well-closed two-leaf clover or jugular vein valve.
  3. 3.根据权利要求1所述的人工生物肺动脉带瓣管道,其特征在于,所述连接在牛颈静脉血管上端的牛心包管道长度为3.5-6.5cm,所述牛颈静脉血管内静脉瓣下缘距离肺动脉带瓣管道下端一段牛颈静脉血管的长度为3.5-6.5cm或连接牛颈静脉血管内静脉瓣下缘的牛心包管道长度为3.5-6.5cm。 The bio-artificial pulmonary conduit with valves according to claim 1, wherein the length of the pipe connecting the vessel bovine pericardium of bovine jugular vein of the upper end of 3.5-6.5cm, under the bovine jugular vein within a venous valve length from the lower edge of some pulmonary valved conduit bovine jugular vein or bovine pericardium is 3.5-6.5cm lower edge of the pipe endovascular venous valve bovine jugular vein was connected to a length of 3.5-6.5cm.
  4. 4.根据权利要求1所述的人工生物肺动脉带瓣管道,其特征在于,所述牛心包组织材料和牛颈静脉血管经化学改性处理。 The bio-artificial pulmonary conduit with valves according to claim 1, wherein the bovine pericardial tissue material and bovine jugular vein treated by chemical modification.
  5. 5.根据权利要求1所述的人工生物肺动脉带瓣管道,其特征在于,所述化学改性处理方法包括用生理盐水或各类组织等渗溶液对新鲜牛颈静脉管组织的漂洗、用浓度为0.3-2.5戊二醛溶液固定2小时以上或用表面活性剂或配位化合物或环氧化合物进行抗钙化处理。 The bio-artificial pulmonary conduit with valves according to claim 1, wherein the chemical modification comprises a treatment method for rinsing tube fresh bovine jugular vein or tissue types of organizations with saline isotonic solution, concentration 2 hours or more fixed or anti-calcification treatment with a surfactant or a coordination compound or an epoxy compound is 0.3 to 2.5 glutaraldehyde solution.
  6. 6.根据权利要求1所述的人工生物肺动脉带瓣管道,其特征在于,所用牛心包组织材料制成的管道接头内径与带瓣牛颈静脉管内径相同。 According to claim bioprosthetic pulmonary valve conduit with claim 1, characterized in that the diameter of the pipe joint made of bovine pericardial tissue material valved bovine jugular vein and an inner diameter the same use.
  7. 7.根据权利要求1所述的人工生物肺动脉带瓣管道,其特征在于,所述高分子材料层为聚酯织物或聚酯无纺膜布,所述高分子材料层上带有标志线。 The bio-artificial pulmonary conduit with valves according to claim 1, wherein said polymer material layer is a non-woven polyester fabric or polyester fabric film, the upper layer of polymer material with a marker line.
CN 200620175187 2006-12-31 2006-12-31 Artificial biological pulmonary artery and valve canal CN200987711Y (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8137411B2 (en) 2010-03-15 2012-03-20 Kemal Schankereli Thin collagen tissue for medical device applications

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8137411B2 (en) 2010-03-15 2012-03-20 Kemal Schankereli Thin collagen tissue for medical device applications

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