CN1985750A - Pulse wave detecting method and device by means of cardiac symbol signal - Google Patents

Pulse wave detecting method and device by means of cardiac symbol signal Download PDF

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CN1985750A
CN1985750A CN 200510022395 CN200510022395A CN1985750A CN 1985750 A CN1985750 A CN 1985750A CN 200510022395 CN200510022395 CN 200510022395 CN 200510022395 A CN200510022395 A CN 200510022395A CN 1985750 A CN1985750 A CN 1985750A
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pulse wave
value
reference
pressure
signal
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CN 200510022395
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CN1985750B (en )
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胡刚
陶波
叶继伦
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深圳迈瑞生物医疗电子股份有限公司
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The present invention discloses method and device for detecting pulse wave by means of cardiac symbol signal. Through detecting the temporal interval between the R wave and the pulse wave, obtain reference interval value, locating searched pulse wave amplitude with the reference interval value and obtaining reference pulse wave amplitude under different pressures, the mean pressure, the systolic pressure and the diastolic pressure are calculated by means of the ratio process. Compared with the available method to search pulse wave peak directly in the pulse wave signal, the present invention has raised anti-jamming capacity and raised blood pressure measuring accuracy especially in case of sports and arrhythmia.

Description

一种利用心跳象征信号检测脉搏波的方法及装置 A method of using a heartbeat pulse wave signal detection symbol and means

【技术领域】本发明涉及一种脉搏波检测方法,尤其涉及利用心电信号来指导脉搏波的查找、增强抗干扰性能的脉搏波检测方法及装置,以及包括该装置的电子血压计。 TECHNICAL FIELD The present invention relates to a pulse wave detection method, in particular, it relates to guide find ECG pulse wave, enhanced pulse wave detecting method and device of the anti-jamming performance, and the apparatus comprising an electronic sphygmomanometer.

【背景技术】目前进行无创血压测量时,通常采用振荡法,其测量过程是先给袖带充气,当压力达到大于人体的收缩压后,则可以认为血管已完全阻断,此时,在袖带处应该不存在脉搏的搏动。 BACKGROUND Currently noninvasive blood pressure measurement time, usually oscillation method, which give the measurement cuff inflation process, when the human body is greater than the systolic pressure is reached, the vessel has been considered to be completely blocked, this time, the sleeve beat with the pulse of the place should not exist. 然后开始缓慢放气或台阶放气,当袖带压力小于收缩压时,血管已经有部分导通,此时脉搏搏动会随着袖带压力的下降而逐渐增强,由于脉搏搏动的影响,将使袖带的压力出现小范围的波动,也即是在压力信号上叠加了一个振荡信号,同样这种振荡信号随着袖带压力的下降而逐渐增强。 Then slowly deflated or the deflation step, when the cuff pressure is less than the systolic pressure, the blood vessel has some turns on, then the pulse beats with decreasing cuff pressure will be gradually increased due to the influence of the pulse beat, would cuff pressure fluctuations small range, i.e., an oscillating signal is superimposed on the pressure signal, such oscillation signal with the same cuff pressure drops gradually increased. 但当袖带压力减小到一定程度后,振荡信号的幅度反而会开始下降。 But when the cuff pressure is reduced to a certain extent, the amplitude of the oscillating signal but will begin to decline. 这主要是因为袖带压力减小,使得人体皮下组织对脉搏搏动的衰减作用逐渐增强。 This is mainly because the cuff pressure is reduced, making the body subcutaneous tissue attenuation pulse beats on gradually. 当袖带压力持续下降,这种衰减作用越来越明显,振荡信号的幅度下降也越明显。 When the cuff pressure continues to drop, more and more obvious effect this attenuation, the amplitude of the oscillation signal decreases the more significant. 通过搜索不同压力下的脉搏波幅度,得到脉搏压力和脉搏波幅度的对应关系曲线。 By searching for the pulse wave amplitude at different pressures, to obtain the corresponding pulse pressure curve and the pulse wave amplitude. 然后查找最大脉搏波幅度对应的压力,认为是平均压;利用平均压对应的脉搏波幅度,乘以收缩压幅度系数,得到收缩压对应的脉搏波幅度,然后根据对应关系曲线向袖带压力高的方向计算出对应的袖带压力,认为是收缩压;利用平均压对应的脉搏波幅度,乘以舒张压幅度系数,得到舒张压对应的脉搏波幅度,然后根据对应关系曲线向袖带压力低的方向计算出袖带的压力,认为是舒张压,这种计算平均压、收缩压和舒张压的方法称为比率法。 Then find the maximum pulse wave amplitude corresponding to the pressure, that is mean pressure; using the average pressure corresponding to the pulse wave amplitude, the systolic blood pressure is multiplied by amplitude coefficients, to obtain the pulse wave amplitude corresponding to systolic pressure, and then to the high cuff pressure based on the correspondence curve direction corresponding to cuff pressure is calculated, that is the systolic pressure; using the average pressure corresponding to the pulse wave amplitude, the amplitude coefficient multiplying DBP, diastolic blood pressure obtained corresponding to the amplitude of the pulse wave, and a low pressure cuff according to the correspondence curve the calculated direction cuff pressure, diastolic pressure is that this method of calculating the average pressure, systolic and diastolic ratio method is called. 传统的测量方法中,测量结果很容易受到手臂运动等各种干扰,导致测不出结果甚至测出偏差较大的结果。 Conventional measuring method, the measurement results are susceptible to various interference arm movement, etc., resulting in no measurable results even larger deviation measured results.

因测量时需要将袖套绑缚在病人胳膊上并充气到一定压力,病人不可避免的感觉到压迫,在无意识的情况下会出现抖动,或者病人的病情导致出现肌颤等情况,或者在手术过程或其它情况下,病人的手臂遭受到外界的触动而意外的抖动等,这些情况下,脉搏波的基线和幅度会受到影响,传统的寻找脉搏波幅值的方法很难保证其准确性,导致识别到错误的脉搏波幅度的概率增大。 Due to the necessary measurement on the patient strapped cuff arm and inflated to a certain pressure, the patient feels inevitable compression, jitter occurs in the case of the unconscious, or the patient's condition and the like lead to muscle trembling occurs, or surgery process or under other circumstances, suffered outside of the patient's arm accidentally touched jitter, etc. in these cases, the baseline and amplitude of the pulse wave will be affected, the traditional method of finding the pulse wave amplitude is difficult to ensure its accuracy, It leads to a probability of erroneous recognition of the pulse wave amplitude increases.

【发明内容】本发明的主要目的就是为了解决现有技术的问题,提供一种检测脉搏波的方法,利用反映心脏跳动的心跳象征信号来减少干扰,提高脉搏波检测的准确性。 SUMMARY OF THE INVENTION The main object of the invention is to solve the problems of the prior art, there is provided a method for detecting the pulse wave by reflecting the heartbeat symbol heart beat signal to reduce interference and improve the accuracy of pulse wave detection.

本发明的另一目的就是为了解决现有技术的问题,提供一种脉搏波检测装置,利用反映心脏跳动的心跳象征信号来减少干扰,提高脉搏波检测的准确性。 Another object of the present invention is to solve the problems of the prior art, there is provided a pulse wave detecting means, using the symbol of the heartbeat signal reflects the heartbeat to reduce interference and improve the accuracy of pulse wave detection.

本发明的又一目的就是提供一种电子血压计,提高脉搏波曲线的准确性,从而提高利用振荡法测量血压的准确性。 A further object of the present invention is to provide an electronic sphygmomanometer, improve the accuracy of the pulse wave curve, thereby improving the accuracy of blood pressure measurement using the oscillometric method.

为实现上述目的,本发明公开了一种利用心跳象征信号检测脉搏波的方法,包括以下步骤:A1、将袖带设置在身体的规定部位;B1、控制袖带充气到一定的压力,使袖带压迫动脉,然后逐渐放气;C1、在放气过程中,采样袖带内的压力;D1、检测出该压力下的脉搏波,采样心电信号,并记录因心脏跳动所产生的心跳象征信号出现的时刻;E1、检测脉搏波相对于心跳象征信号的参考延迟值;F1、在心跳象征信号延迟参考延迟值后的有效范围内搜索脉搏波;G1、根据搜索出的脉搏波得到该压力下的基准脉搏波。 To achieve the above object, the present invention discloses a method of using a heartbeat pulse wave signal detection symbol, comprising the steps of: A1, is provided in a predetermined portion of the cuff body; Bl, the control cuff inflated to a certain pressure, so that sleeves oppressive artery, and then gradually deflated; a C1, during deflation, the pressure within the cuff samples; Dl, due to heart beating heart symbol generated pulse wave detected at that pressure, ECG sampling and recording timing signal appears; E1, detect the pulse wave with respect to the heartbeat symbol signal reference delay value; F1, heartbeat symbol delayed signal within the effective range of the reference delay value search pulse wave; G1, to obtain the pressure of the search pulse wave under the reference pulse wave.

其中,所述心跳象征信号优选为R波或血氧脉搏波。 Wherein the symbol of the heartbeat signal is preferably oxygen or the R-wave of the pulse wave.

其中,所述有效范围为以心跳象征信号延迟参考延迟值后的点为中心前后1/15秒的范围。 Wherein said effective range to a point after the heartbeat signal delayed reference symbol delay values ​​in the range of 1/15 second longitudinal center.

其中,所述步骤E1的优选方案包括以下步骤:E11、检测心跳象征信号和检测出的脉搏波之间的间距值;E12、建立间距数组,所述间距数组中的间距值两两之间相差全部小于设定差值;E13、将间距数组中的间距值平均后作为参考延迟值。 Wherein said step E1 preferred embodiment comprises the steps of: spacing value between the E11, a symbol of the heartbeat detection signal and the pulse wave detected; E12, establishing an array pitch, the pitch of the array of difference values ​​between any two all smaller than the set difference; E13, the array pitch of the average value as the reference delay value.

上述步骤的优选方案是:所述间距值数组中的间距值的最小数量是3个,所述设定差值为1/15秒。 Preferred embodiment of the above step is: the value of the minimum number of pitch values ​​in the array spacing is 3, the difference is set to 1/15 seconds.

为不断对参考延迟值进行修正,在步骤E13之后还包括以下步骤:E14、在心跳象征信号延迟参考延迟值后的有效范围内搜索下一个脉搏波,并将该脉搏波与相应心跳象征信号的间距值加入间距数组;E15、将间距数组的间距值进行排序,寻找与数组内的其他间距值两两相差小于设定差值最多的间距值的集合;E16、用集合内间距值的平均值更新参考延迟值。 To continue the reference retardation value is corrected, after step E13 further comprising the step of: E14, delay in the search heartbeat signal symbol within the effective range of a retardation value after the reference pulse wave, and the pulse wave signal corresponding to a symbol of the heartbeat an array pitch spacing value added; E15, the array pitch spacing value sort to find the set of the other array pitch values ​​twenty-two differ by less than the difference between the pitch set up value; E16, with the average pitch value within the set updating the reference value delay.

为实现上述目的,本发明还公开了一种脉搏波检测装置,包括:袖带,设置在身体的规定部位;气压控制模块,对袖带进行充气到一定的压力,使袖带压迫动脉,并能够逐渐放气;压力检测模块,检测所述袖带内的压力;脉搏波检测模块,检测脉搏搏动因受袖带压迫而产生的脉搏波信号;心电信号检测模块,检测因心脏跳动所产生的心跳象征信号,并记录其出现的时刻;参考延迟值检测模块,检测脉搏波相对于心跳象征信号在时间上的的参考延迟值;脉搏波搜索模块,用于在心跳象征信号延迟参考延迟值后的有效范围内搜索脉搏波;基准脉搏波计算模块,根据搜索出的脉搏波得到不同压力下的基准脉搏波。 To achieve the above object, the present invention also discloses a pulse wave detecting apparatus, comprising: a cuff, provided in a predetermined portion of the body; pressure control module, the cuff is inflated to a certain pressure, the cuff artery compression, and can be gradually deflated; pressure detecting module, detecting the pressure in said cuff; pulse wave detection module, a pulse wave detecting a pulse beat signal generated due to compression of the cuff; ECG detection module detects the heart beat generated by the symbol of the heartbeat signal, and records the time of occurrence thereof; reference delay value detection module, detecting a pulse wave with respect to the reference signal delay value in the heartbeat symbol time; wave pulse search module configured to delay the reference heartbeat signal delay value symbol search within the effective range rear pulse wave; and the reference pulse wave calculating module, the reference pulse wave obtained at different pressures according to a search pulse wave.

其中,所述心跳象征信号优选为R波或血氧脉搏波。 Wherein the symbol of the heartbeat signal is preferably oxygen or the R-wave of the pulse wave.

其中,所述有效范围为以心跳象征信号延迟参考延迟值后的点为中心前后1/15秒的范围。 Wherein said effective range to a point after the heartbeat signal delayed reference symbol delay values ​​in the range of 1/15 second longitudinal center.

所述参考延迟值检测模块包括:间距值检测单元,检测心跳象征信号和检测出的脉搏波之间的间距值;间距数组处理单元,建立间距数组,所述间距数组中的间距值两两之间相差全部小于设定差值;参考延迟值计算单元,将间距数组中的间距值平均后作为参考延迟值。 Said reference delay value detection module comprises: a distance value between the distance value detecting means for detecting a heartbeat signal and the symbol of the detected pulse wave; pitch array processing unit, establish an array pitch, the pitch of every two values ​​in the array of setting a difference between a difference of less than all; delay reference value calculating means, the pitch of the array as the reference value of the average delay value.

所述间距值数组中的间距值的最小数量优选是3个,所述设定差值优选为1/15秒。 Preferably the minimum number of pitch values ​​of the pitch values ​​in the array is three, the difference is preferably set to 1/15 seconds.

为不断对参考延迟值进行修正,本发明的进一步改进是:还包括参考延迟值更新模块,用于将在心跳象征信号延迟参考延迟值后的有效范围内搜索到的下一个脉搏波与相应心跳象征信号的间距值加入间距数组,将间距数组的间距值进行排序,寻找与数组内的其他间距值两两相差小于设定差值最多的间距值的集合,用集合内间距值的平均值更新参考延迟值检测模块中的参考延迟值。 To continue the reference retardation value is corrected, the present invention is a further improvement: further comprising a reference delay value updating module, configured to search within the effective range of the retardation value of the reference heartbeat symbol delay signal in a pulse wave corresponding to the heartbeat symbol spacing value added signal pitch array, the array pitch of the pitch values ​​are sorted to find other values ​​within an array pitch difference twenty-two set smaller than a maximum value of the pitch difference is set, updated with the average value within the set of pitch the reference value of the reference delay value of delay detection module.

为实现上述目的,本发明还公开了一种电子血压计,包括:袖带,设置在身体的规定部位;气压控制模块,对袖带进行充气到一定的压力,使袖带压迫动脉,并能够逐渐放气;压力检测模块,检测所述袖带内的压力;脉搏波检测模块,检测脉搏搏动因受袖带压迫而产生的脉搏波信号;心电信号检测模块,检测因心脏跳动所产生的心跳象征信号,并记录其出现的时刻;参考延迟值检测模块,检测脉搏波相对于心跳象征信号在时间上的的参考延迟值;脉搏波搜索模块,用于在心跳象征信号延迟参考延迟值后的有效范围内搜索脉搏波;基准脉搏波计算模块,根据搜索出的脉搏波得到不同压力下的基准脉搏波;血压计算模块,根据得出的压力序列和基准脉搏波序列,采用比率法计算平均压、收缩压和舒张压。 To achieve the above object, the present invention also discloses an electronic sphygmomanometer comprising: a cuff, provided in a predetermined portion of the body; pressure control module, the cuff is inflated to a certain pressure, the cuff artery compression, and can be pulse wave signals pulse wave detection module that detects a cuff pulse beats due to compression produced;; gradually deflated; pressure detecting module detecting pressure in the cuff ECG detection module detects the heart beat generated by symbol of the heartbeat signal, and records the time of occurrence thereof; reference delay value detection module, detecting a pulse wave with respect to the reference signal delay value in the heartbeat symbol time; wave pulse search module configured to delay the reference symbol of the retardation value in the heartbeat signal search within the effective range of the pulse wave; reference pulse wave calculating module, the reference pulse wave obtained at different pressures according to a search pulse wave; blood pressure calculation module, based on the pressure pulse wave reference sequence and the sequence obtained, using the method of calculating the average ratio pressure, systolic and diastolic blood pressure.

为实现上述目的,本发明还公开了一种电子血压计,包括:袖带,设置在身体的规定部位;气压控制模块,对袖带进行充气到一定的压力,使袖带压迫动脉,并能够逐渐放气;压力检测模块,检测所述袖带内的压力;脉搏波检测模块,检测脉搏搏动因受袖带压迫而产生的脉搏波信号;心电信号检测模块,检测因心脏跳动所产生的心跳象征信号,并记录其出现的时刻;处理模块,用于检测脉搏波相对于心跳象征信号的参考延迟值,在心跳象征信号延迟参考延迟值后的有效范围内搜索脉搏波,根据搜索出的脉搏波得到不同压力下的基准脉搏波,根据得出的压力序列和基准脉搏波序列,采用比率法计算平均压、收缩压和舒张压。 To achieve the above object, the present invention also discloses an electronic sphygmomanometer comprising: a cuff, provided in a predetermined portion of the body; pressure control module, the cuff is inflated to a certain pressure, the cuff artery compression, and can be pulse wave signals pulse wave detection module that detects a cuff pulse beats due to compression produced;; gradually deflated; pressure detecting module detecting pressure in the cuff ECG detection module detects the heart beat generated by symbol of the heartbeat signal, and records the time of occurrence thereof; processing means for detecting a pulse wave with respect to the reference symbol delay value of the heartbeat signal, the effective search range of the pulse wave in the delayed reference symbol delay value of the heartbeat signal, according to the searched out reference pulse wave of the pulse wave obtained at different pressures, depending on the pressure pulse wave reference sequence and the sequence obtained, using the method of calculating the ratio mean pressure, systolic and diastolic pressure.

本发明的效果:1)利用心脏跳动后喷出的血液对血管的压迫力传递到手臂血管臂的延迟时间对同一个人基本保持不变的原理,在R波或血氧脉搏波出现后固定时间区域内寻找脉搏波,可有效排除干扰,提高脉搏波检测的准确性。 Effects of the Invention: 1) after the discharge using the beating heart blood vessels compressive force on the arm is transmitted to the delay time for the same individual vessels arm remains substantially the same principle, a fixed time after the R-wave or a pulse wave occurs oximetry find the area of ​​the pulse wave, can effectively eliminate interference, improve the accuracy of pulse wave detection. 2)合理检测出R波或血氧脉搏波与脉搏波的参考延迟值,有利于脉搏波的定位搜索,更进步减少了将干扰信号作为脉搏波的几率。 2) the reference delay reasonable value detected R wave or blood oxygen and pulse wave of the pulse wave, the pulse wave facilitate positioning of the search, reducing the chance of the more progressive signal as the pulse wave interference. 3)根据后面检测的R波或血氧脉搏波和脉搏波,不断修正参考延迟值,使用于指导脉搏波定位搜索的参考延迟值更接近实际间距,又进一步提高了脉搏波检测的抗干扰性和准确性。 3) The R-wave detected by the pulse wave or blood oxygen and pulse wave constantly corrected reference delay value, using the pulse wave guide positioned in the search reference delay value closer to the actual distance, but also further improve the pulse wave detection immunity and accuracy.

本发明的特征及优点将通过实施例结合附图进行详细说明。 Features and advantages of the invention will be described in detail by way of example in conjunction with the accompanying drawings.

【附图说明】图1是本发明一种实施例的连接框图;图2是本发明一种实施例的流程图;图3是图2中获取参考延迟值的流程图;图4是更新参考延迟值的流程图;图5是图2中用R波指导脉搏波定位搜索的流程图。 BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a block diagram of one embodiment of the connector of the present invention; FIG. 2 is a flow diagram of one embodiment of the present invention; FIG. 3 is a flowchart of acquiring a reference value of delay in FIG. 2; FIG. 4 is an updated reference flowchart delay value; FIG. 5 is a flowchart of FIG. 2 with the R wave of the pulse wave guide positioning search.

【具体实施方式】如图1所示,袖带用于在测量血压时佩戴在被测身体的规定部位,通常是佩戴在手臂上,也可以佩戴在手腕上。 DETAILED DESCRIPTION OF EMBODIMENTS As shown in FIG 1, for wearing the cuff body at a predetermined portion of the test, usually worn on the arm, can be worn on the wrist during blood pressure measurement. 气压控制模块与袖带相连通,气压控制模块包括马达、充气单元、阀门和逻辑控制单元,马达、充气单元、袖带、阀门构成充气通路,受逻辑控制单元的控制。 The air pressure control module in communication with the cuff, the air pressure control module includes a motor, a pneumatic unit, a logic control unit and a valve, motor, pneumatic means, cuff, pneumatic valve constituting the path, controlled by the logic control unit. 首先关闭阀门,给马达上电,让袖套充气到指定的压力,然后停止充气,打开阀门,控制放气阀对袖带进行逐渐放气,例如台阶放气。 First close the valve, to the electric motor, so that the cuff is inflated to a specified pressure, and then to stop inflation, the valve is opened, the purge valve of the control cuff is gradually deflated, such as a step deflation. 压力检测模块包括压力传感器、放大器和A/D转换器,压力传感器被放置在袖带内与动脉靠近,在放气过程中,压力传感器检测袖带内的压力,将压力转换成电信号输出,放大器将电信号进行放大,然后分成两路,其中第一路直接输出到A/D转换器,计算后获得当前的压力。 Pressure sensing module includes a pressure sensor, an amplifier and A / D converter, a pressure sensor is placed within the artery with the cuff close, during deflation, the pressure sensor detects the pressure in the cuff, converting pressure into an electrical signal output, the amplifier amplifies an electric signal, and then divided into two, wherein a first output directly to the a / D converter, the current pressure is obtained after calculation. 第二路输出到脉搏波检测模块,脉搏波检测模块包括高通滤波器,滤掉直流的压力信号,然后放大输出到A/D转换器,获得交流的脉搏波信号。 A second output to the pulse wave detection module, the pulse wave detection module includes a high pass filter, pressure filtered DC signal, and then amplified output to the A / D converter to obtain a pulse wave signal communication. 心电信号检测模块,利用现有手段检测出R波,并记录其出现的时刻。 ECG detection module, using conventional means for detecting the R wave, and the recording time in which they appear. 参考延迟值检测模块接收心电信号检测模块输出的R波和其出现的时刻,同时也接收脉搏波检测模块输出的脉搏波,将脉搏波与R波相比较,检测出脉搏波相对于R波在时间上的参考延迟值。 R-wave and its time reference delay occurring value detection module receives electrocardiographic signal detection module output, while also receiving a pulse wave of the pulse wave detection module outputs the pulse wave and R-wave comparing the detected pulse wave with respect to the R-wave reference delay value over time. 脉搏波搜索模块根据参考延迟值来指导脉搏波的定位搜索,即将R波出现的时刻延迟参考延迟值后的有效范围内搜索脉搏波,该有效范围优选为延迟参考延迟值后的点为中心前后1/15秒的范围,如果以75Hz的采样频率来采样,则该有效范围为延迟参考延迟值后的点为中心的前后5个采样点,不在这个范围内搜索到的脉搏波,认为不是血压脉搏波幅值,是干扰。 Pulse wave search module according to the reference delay value to guide target search pulse wave, the time is about the R-wave delay occurring within the effective range of the reference delay value search pulse wave, the effective range is preferably point delayed reference delay value for the longitudinal center range of 1/15 seconds, if the sampling frequency of 75Hz to sampling, the effective range of the reference point after the delay of the delay value as the center of five samples before and after the search is not inside the pulse wave, blood pressure is not considered pulse wave amplitude, the interference. 参考延迟值更新模块接收脉搏波搜索模块在R波延迟参考延迟值后的有效范围内搜索到的下一个脉搏波,并将该脉搏波与相应心跳象征信号的间距值加入间距数组,将间距数组的间距值进行排序,寻找与数组内的其他间距值两两相差小于设定差值最多的点的集合,用集合内间距值的平均值更新参考延迟值检测模块中的参考延迟值。 Reference delay value updating module to the next pulse wave within range searched after the searching module receives the delayed reference pulse wave retardation value of R-wave, and the added value of the pitch pulse wave signal corresponding to the heartbeat symbol pitch array, the array pitch pitch values ​​are sorted to find the value of the array pitch twenty-two other by less than the difference between a maximum set point set, to update the reference values ​​of the reference delay value of the delay detection module is an average value within the set of pitch values. 基准脉搏波计算模块根据同一压力下找到的若干个脉搏波峰值,采用相似波聚类法,找出相似的脉搏波幅值,平均后做为当前压力下的基准脉搏波幅值。 The reference pulse wave calculating module number to find the pulse wave peak at the same pressure, a similar wave clustering method to identify similar pulse amplitude, mean amplitude of the reference pulse wave value as the current pressure. 上述各模块组成脉搏波检测装置,然后将A/D转换后的压力序列和与压力相对应的基准脉搏波序列可以先存储在存储模块中,优化处理模块读取存储模块中的压力序列和基准脉搏波序列,对压力序列和基准脉搏波序列进行归一化、插值、加权平均等处理,然后输出到血压计算模块,血压计算模块采用比率法计算平均压、收缩压和舒张压,因提高了脉搏波曲线的准确性,从而实现血压测量的抗干扰,提高利用振荡法测量血压的准确性。 Each of the modules of the pulse wave detecting means, and then the pressure sequence A / D conversion and the pressure pulse wave corresponding to the reference sequence may be previously stored in the storage module, and the reference sequence to optimize pressure processing module reads the stored module wave pulse sequence, the sequence of pressure pulse wave and a reference sequence is normalized, interpolation, weighted average processing, and then outputted to the blood pressure calculation module, using the blood pressure calculation module calculates the average pressure, systolic and diastolic ratio method, due to improved the accuracy of the pulse wave curve, in order to achieve interference of blood pressure measurement to improve the accuracy of blood pressure measurement using the oscillometric method. 还可以进一步计算出脉率。 May further calculate the pulse rate.

上述的参考延迟值检测模块、参考延迟值更新模块、脉搏波搜索模块、基准脉搏波计算模块、存储模块、优化处理模块和血压计算模块还可以集成在处理模块中,采用软件方式完成,例如集成在单片机中。 Above reference delay value detection module, the reference delay value updating module, a pulse wave search module, the reference pulse wave calculating module, a storage module, optimization processing module, and the blood pressure calculation module may also be integrated in the processing module, using the software is accomplished, for example, integrated in the microcontroller.

由于R波、血氧脉搏波周期和脉搏波周期反应的都是心跳频率,故相对应的R波或血氧脉搏波和脉搏波的间距是一定的,这个间距反应为自心脏跳动后,血液传递脉动到手臂的时间,对于同一个人这个时间延迟是一定的,没有什么变化。 Since the R-wave are heart rate, blood oxygen and pulse wave periods in pulse wave period of the reaction, so that a pitch corresponding to the R-wave pulse wave or blood oxygen and pulse wave is constant, since this reaction is a pitch of the heart beat, blood pulsatile delivery time to the arm, for the same person this time delay is certain, nothing changes. 根据这一特征,可以只在R波或血氧脉搏波后一定间距内寻找脉搏波,能有效的去除干扰。 According to this feature, the pulse wave can only find the R-wave in the pulse wave or blood oxygen at a distance, can effectively remove interference. 本实施例的具体流程如图2所示,包括以下步骤:在步骤1,将袖带充放气到一个压力台阶;在步骤2,在当前压力台阶下,定时中断中,对振荡信号也即是脉搏波信号进行采样,并对采样数据进行预处理;对R波脉冲进行采样,并记录R波脉冲出现的时刻,然后执行步骤3;在步骤3,判断是否为第一个压力台阶,如果是,则执行步骤4,如果不是则执行步骤5;在步骤4,获取R波与对应的脉搏波之间的参考间距值,然后执行步骤6;在步骤5,更新参考间距值,然后执行步骤6;在步骤6,根据参考间距值定位脉搏波的搜索范围,并搜索出该范围内的脉搏波,其搜索范围的优选方案是将R波延迟参考延迟值后的点为中心前后1/15秒范围内的脉搏波。 DETAILED flow of the embodiment shown in Figure 2, comprising the following steps: In step 1, the cuff inflation and deflation to a pressure level; in step 2, the pressure at the current step, the timer interrupt, i.e., the oscillation signal pulse wave signal is sampled, and the sampled data preprocessing; the R-wave pulse is sampled and the recording time of the R-wave pulse occurs, then step 3; in step 3, it is determined whether a pressure for the first step, if yes, step 4, step 5 is performed if it is not; in step 4, acquires the reference distance value between the R wave of the pulse wave corresponding to, and then step 6; in step 5, the pitch update the reference value, then step 6; before and after step 6, the search range of the reference value of the positioning pitch of the pulse wave, and the pulse wave within the search range, the search range of the preferred embodiment which is a point after the R-wave retardation value as the center of the reference delay 1/15 the range of the second pulse wave. 然后执行步骤7;在步骤7,将同一压力下的脉搏波进行相似聚类法处理,找出相似的脉搏波幅值,平均后做为当前压力下的基准脉搏波幅值,然后执行步骤10;在步骤8,定时中断中,对袖带压力值进行采样,然后执行步骤9;在步骤9,对压力采样信号进行处理,并将采样值转换成压力单位mmHg值,获得当前压力值,然后执行步骤10;在步骤10,判断是否继续放气,如果需要继续放气,则转向执行步骤1,如果不需要继续放气,则执行步骤11;在步骤11,得到压力序列和基准脉搏波序列。 Then step 7; In step 7, the pressure pulse wave at the same similarity clustering processing method to identify a similar pulse amplitude, mean amplitude of the reference pulse wave value as the current pressure, and the step 10 ; in step 8, the timer interrupt, the cuff pressure values ​​are sampled, then step 9; in step 9, the pressure of the sampling signal processing and converts the sampled values ​​into a pressure unit mmHg value, the current pressure value is obtained, and then step 10; step 10, it is determined whether to continue deflated, deflated if necessary to continue, go to step 1, if no deflation continues, step 11; step 11, to obtain a pressure pulse wave sequence and a reference sequence .

如果需要利用脉搏波来计算血压,可再进一步执行步骤12;在步骤12,对压力序列和基准脉搏波序列进行优化处理,例如归一化、插值和加权平均处理,然后执行步骤13;在步骤13,查找出幅值最大的脉搏波,该脉搏波幅值所对应的压力值为平均压,然后执行步骤14;在步骤14,根据经验所得的幅度系数,利用比率法计算收缩压和舒张压。 If you need to calculate the blood pressure using the pulse wave, can be further executes step 12; step 12, pressure sequence and the reference pulse wave sequence optimization processing, e.g. normalization, interpolation, and weighted average processing, then step 13; step 13, to find the maximum amplitude of the pulse wave, the pulse wave amplitude corresponding to the mean pressure value of the pressure, and then step 14; step 14, the resulting amplitude coefficients in accordance with the experience of using the method to calculate the ratio of systolic and diastolic pressure .

对于在不同压力下得到的一系列基准脉搏波信号还可以进行变化趋势判断,对于不满足放气过程中压力底下脉搏波幅度变化趋势的脉搏波幅度删除,以确保此基准脉搏波序列符合比率法所需要满足的一些特性。 For a series of reference pulse wave signals obtained at different pressures may also be determined trends, does not meet the deflation process under pressure pulse wave amplitude trends of pulse wave amplitude deleted to ensure that this sequence corresponds to the ratio of the reference pulse wave method the need to meet some of the features.

上述步骤中,首次获取参考延迟值的流程如图3所示,包括以下步骤:在步骤401,接收R波和与该R波对应的脉搏波,检测R波和该脉搏波之间的间距值,然后执行步骤402;在步骤402,建立间距数组,将间距值放入间距数组,然后执行步骤403;在步骤403,判断间距数组中间距值的数量是否大于2,如果是则执行步骤404,如果不是则转向执行步骤401,继续检测R波和下一个脉搏波之间的间距值;在步骤404,计算间距数组中的间距值两两之间的差值,如果该间距值与其它间距值的相差全部小于1/15秒,则将该间距值保留在间距数组中,然后执行步骤405,如果该间距值与其它间距值的差值不是全部小于1/15秒,则将该间距值删除;该步骤中,将设定差值优选为1/15秒,是因为设定差值太小的话容易漏检血压脉搏波,设定差值太大的话抗干扰性能会降低,如果以75Hz的采 In the above step, the first reference delay value acquiring process shown in Figure 3, comprising the following steps: In Step 401, and receives the R-wave spacing values ​​between the pulse wave, R-wave detection and the pulse wave corresponding to the R-wave , then step 402; step 402, establishing an array pitch of the array pitch into pitch value, then step 403 is performed; at step 403, determines the number of pitch values ​​in the array spacing is greater than 2, and if yes, step 404 is performed, If not, then go to step 401 to continue the detection value of the spacing between the next R-wave and a pulse wave; at step 404, calculates a difference between the pitch of the array pitch values ​​every two, if the pitch value with the other pitch values all differ less than 1/15 second, the value retained in the pitch array pitch, then the step 405, if the difference between the pitch value and the pitch value other than all less than 1/15 second, the value of the pitch deleted ; in this step, the difference is preferably set to 1/15 seconds, because the difference is too small to set easily missed blood pressure and pulse wave, a difference is set too large anti-jamming performance is reduced, if the 75Hz collection 样频率来采样,则设定差值优选为5个采样点;在步骤405,判断间距数组中的间距值的数量是否达到3,如果是则执行步骤406,如果不是则执行步骤401;在步骤406,将间距数组中的间距值平均后作为参考延迟值。 Sampling the sampling frequency, the difference is preferably set to five samples; at step 405, determines the number of array pitch spacing value has reached 3, and if yes, step 406 is performed, if not step 401 is performed; at step 406, the pitch of the array as the reference value of the average delay value.

上述步骤中,更新参考延迟值的流程如图4所示,包括以下步骤:在步骤501,在R波延迟参考延迟值后的有效范围内搜索下一个脉搏波,然后执行步骤502;在步骤502,在脉搏波的搜索中已经找到波谷和脉搏波基准点,然后执行步骤503;在步骤503,计算该脉搏波与前一个R波之间的间距值,并将该间距值加入间距数组,然后执行步骤504;在步骤504,判断间距数组的间距值的数量是否大于2,如果是则执行步骤505,如果不是则转向步骤501,继续搜索下一个脉搏波;在步骤505,将间距数组的间距值进行排序,然后执行步骤506;在步骤506,寻找与数组内的其他间距值两两相差小于5最多的间距值,组成集合,如果符合条件的间距值只有一个,则将该间距值和其附近的间距值一起组成集合,然后执行步骤507; The above steps, the process of updating the reference delay values ​​shown in Figure 4, comprising the following steps: In step 501, the delay in the search for the next R wave within the effective range of a pulse wave after a delay of the reference value, then step 502; step 502 , troughs and have found a pulse wave reference point of the pulse wave in the search, then step 503; step 503 calculates the distance between the pulse wave value of the previous R-wave, and the pitch value is added to the array pitch, and performing step 504; step 504, the number of pitch values ​​determines the pitch of the array is greater than 2, and if yes, perform step 505, if not then go to step 501, with continued search for a pulse wave; in step 505, the pitch of the array values ​​are sorted, and then step 506; step 506, to find other values ​​within the array pitch and any two of the phase difference value is smaller than the distance up to 5, to form a set, if only qualifying a spacing value, which is the spacing value and pitch value near the set consisting together, and then step 507 is executed;

在步骤507,将集合内的间距值进行平均,然后执行步骤508;在步骤508,用集合内间距值的平均值更新为参考延迟值。 In step 507, the pitch value in the set of average, then step 508; step 508, the mean value within the set of pitch delay value is updated to the reference value.

其中用R波指导脉搏波定位搜索的流程如图5所示,包括以下步骤:在步骤601,在R波延迟参考延迟值后的有效范围内搜索下一个脉搏波,然后执行步骤602;在步骤602,判断该脉搏波与相应R波之间的间距值是否在参考延迟值的正负5的范围内,即判断该脉搏波是否在将R波延迟参考延迟值后的点为中心前后5个点的范围内,如果是则执行步骤603,如果不是则将该脉搏波丢弃,然后执行步骤601;在步骤603,保存当前脉搏波幅度,进入脉搏波序列判断。 Wherein R wave pulse wave guide with a target search process shown in Figure 5, comprising the following steps: In step 601, the delay in the search for the next R wave within the effective range of a pulse wave after a delay of the reference value, then step 602; step 602, it is determined spacing value between the pulse wave corresponding to the R-wave retardation in the range of the reference value of plus or minus 5, i.e., after the point is determined whether the pulse wave of the R-wave retardation in the retardation value before and after the reference center 5 the range of the point, if step 603 is executed, if the pulse wave is not discarded, then step 601; step 603, to save the current amplitude of the pulse wave, the pulse wave into the sequence determination.

经过试验室测试证明,在使用BIO-TECK模拟器,输出各种干扰类型的情况下,引入心电R波来定位脉搏波搜索的算法,能测量出更准确的血压结果,对比结果见表1。 After laboratory tests proved that in the case of using BIO-TECK simulator, the output of various types of interference, ECG R-wave is introduced to locate the pulse wave search algorithm can be a more accurate blood pressure measurement results, compare the results in Table 1 .

表1 Table 1

从表中可以看出,在四种模式下,加入R波抗干扰算法,测量准确性明显提高,特别在运动等级8模式下,引入R波抗干扰算法,可以准确的计算出血压值。 As can be seen from the table, in the four modes, was added R-wave interference algorithm, the accuracy of measurement significantly improved, especially in the motion level pattern 8, introduction of the R-wave interference algorithm, can accurately calculate the blood pressure value.

同理,将上述实施例中的心电R波换成血氧脉搏波上的特征点,比如峰值点或谷值点,也可以用来指导和定位血压脉搏波的搜索。 Similarly, the above-described embodiments of the ECG R-wave characteristic points on the oxygen into pulse wave, such as the peak point or valley points may be used to guide the search for and locate blood pressure pulse wave.

综上所述,本发明采用心电R波信号来定位的搜索脉搏波幅度,和当前大多数血压测量采用的直接在脉搏波信号中搜索脉搏波峰值的方法相比,提高了抗干扰的能力,在运动、心率不齐存在的情况下,可以有效提高血压测量准确性。 In the pulse wave signal directly compared summary, the present invention employs the ECG R-wave signal to locate the pulse wave amplitude search, and most of the current blood pressure measurement using the pulse wave peak search methods to improve the anti-interference ability in the presence of motion, arrhythmias, blood pressure can effectively improve the measurement accuracy.

Claims (14)

  1. 1.一种利用心跳象征信号检测脉搏波的方法,其特征在于包括以下步骤:A1、将袖带设置在身体的规定部位;B1、控制袖带充气到一定的压力,使袖带压迫动脉,然后逐渐放气;C1、在放气过程中,采样袖带内的压力;D1、检测出该压力下的脉搏波,采样心电信号,并记录因心脏跳动所产生的心跳象征信号出现的时刻;E1、检测脉搏波相对于心跳象征信号的参考延迟值;F1、在心跳象征信号延迟参考延迟值后的有效范围内搜索脉搏波;G1、根据搜索出的脉搏波得到该压力下的基准脉搏波。 1. A method of detecting a heartbeat signal symbol using a pulse wave, comprising the steps of: A1, is provided in a predetermined portion of the cuff body; Bl, the control cuff inflated to a certain pressure, the cuff artery compression, then gradually deflated; a C1, during deflation, the pressure within the cuff samples; Dl, pulse wave detected at that pressure, ECG sample, recording time and the heartbeat signal symbol generated by the heart beat appears ; E1, detect the pulse wave with respect to the reference delay value heartbeat symbol signal; F1, searches the pulse wave within the effective range of delayed reference delay value heartbeat symbol signal; G1, to give a reference pulse at that pressure the search pulse wave wave.
  2. 2.如权利要求1所述的方法,其特征在于:所述心跳象征信号为R波或血氧脉搏波。 2. The method according to claim 1, wherein: said signal is a heartbeat symbol R-wave or wave pulse oximeter.
  3. 3.如权利要求2所述的方法,其特征在于:所述有效范围为以心跳象征信号延迟参考延迟值后的点为中心前后1/15秒的范围。 The method according to claim 2, wherein: the effective range of the point in the heartbeat signal delayed reference symbol delay values ​​in the range of 1/15 second longitudinal center.
  4. 4.如权利要求1至3中任一项所述的方法,其特征在于:所述步骤E1包括以下步骤:E11、检测心跳象征信号和检测出的脉搏波之间的间距值;E12、建立间距数组,所述间距数组中的间距值两两之间相差全部小于设定差值;E13、将间距数组中的间距值平均后作为参考延迟值。 4. The method of 1 to 3 of any one of the preceding claims, characterized in that: said step comprises the steps E1: E11 spacing value between, the symbol of the heartbeat detection signal and the pulse wave detected; E12, establishing pitch array, the array pitch of the phase difference value between any two of all smaller than the set difference; E13, the array pitch of the average value as the reference delay value.
  5. 5.如权利要求4所述的方法,其特征在于在:所述间距值数组中的间距值的最小数量是3个,所述设定差值为1/15秒。 5. The method according to claim 4, characterized in that: the value of the minimum number of pitch values ​​in the array spacing is 3, the difference is set to 1/15 seconds.
  6. 6.如权利要求4或5所述的方法,其特征在于在步骤E13之后还包括以下步骤:E14、在心跳象征信号延迟参考延迟值后的有效范围内搜索下一个脉搏波,并将该脉搏波与相应心跳象征信号的间距值加入间距数组;E15、将间距数组的间距值进行排序,寻找与数组内的其他间距值两两相差小于设定差值最多的间距值的集合;E16、用集合内间距值的平均值更新参考延迟值。 6. A method as claimed in claim 4 or claim 5, characterized in that after step E13 further comprising the step of: E14, the heartbeat signal is delayed for a next symbol of the pulse wave within the effective range of the reference delay value, and the pulse wave spacing value corresponding to a symbol of the heartbeat signals added pitch array; E15, the array pitch spacing value sort to find other values ​​within an array pitch difference twenty-two set smaller than the difference between the pitch of the set up value; E16, with average pitch value within the set of updated reference delay value.
  7. 7.一种脉搏波检测装置,包括:袖带,设置在身体的规定部位;气压控制模块,对袖带进行充气到一定的压力,使袖带压迫动脉,并能够逐渐放气;压力检测模块,检测所述袖带内的压力;脉搏波检测模块,检测脉搏搏动因受袖带压迫而产生的脉搏波信号;其特征在于还包括:心电信号检测模块,检测因心脏跳动所产生的心跳象征信号,并记录其出现的时刻;参考延迟值检测模块,检测脉搏波相对于心跳象征信号的参考延迟值;脉搏波搜索模块,用于在心跳象征信号延迟参考延迟值后的有效范围内搜索脉搏波;基准脉搏波计算模块,根据搜索出的脉搏波得到不同压力下的基准脉搏波。 A pulse wave detecting apparatus, comprising: a cuff, provided in a predetermined portion of the body; pressure control module, the cuff is inflated to a certain pressure, the cuff artery compression, and can be gradually deflated; the pressure sensing module , detecting the pressure in said cuff; pulse wave detection module, detecting pulsation due to pulse compression cuff pulse wave signal produced; characterized by further comprising: electrocardiographic signal detection module, detecting the heartbeat by heartbeat generated symbol signal, and records the time of occurrence thereof; reference delay value detection module, detecting a pulse wave with respect to the reference symbol of the retardation value of the heartbeat signal; wave pulse search module, within the effective range for the delay value of the reference heartbeat symbol delay signal search pulse wave; reference pulse wave calculating module, the reference pulse wave obtained at different pressures according to a search pulse wave.
  8. 8.如权利要求7所述的脉搏波检测装置,其特征在于:所述心跳象征信号为R波或血氧脉搏波。 The pulse wave detecting apparatus as claimed in claim 7, wherein: said signal is a heartbeat symbol R-wave or wave pulse oximeter.
  9. 9.如权利要求8所述的脉搏波检测装置,其特征在于:所述有效范围为以心跳象征信号延迟参考延迟值后的点为中心前后1/15秒的范围。 9. The pulse wave detecting apparatus according to claim 8, wherein: the effective range of the point in the heartbeat signal delayed reference symbol delay values ​​in the range of 1/15 second longitudinal center.
  10. 10.如权利要求7至9中任一项所述的脉搏波检测装置,其特征在于:所述参考延迟值检测模块包括:间距值检测单元,检测心跳象征信号和检测出的脉搏波之间的间距值;间距数组处理单元:建立间距数组,所述间距数组中的间距值两两之间相差全部小于设定差值;参考延迟值计算单元,将间距数组中的间距值平均后作为参考延迟值。 10. The pulse wave detection device according to any one of claims 7 to 9, characterized in that: the reference value of delay detection module comprising: a spacing between the value detection unit detects a heartbeat signal and a symbol of the pulse wave detected spacing value; pitch array processing unit to: establish an array pitch, the pitch of all the values ​​in the array differ by less than a set difference between any two; delay reference value calculating means, the average value of the pitch of the array as a reference delay value.
  11. 11.如权利要求10所述的脉搏波检测装置,其特征在于:所述间距值数组中的间距值的最小数量是3个,所述设定差值为1/15秒。 11. The pulse wave detection apparatus according to claim 10, wherein: said minimum number of the pitch spacing value of values ​​in the array is three, the difference is set to 1/15 seconds.
  12. 12.如权利要求10或11所述的脉搏波检测装置,其特征在于还包括:参考延迟值更新模块,用于将在心跳象征信号延迟参考延迟值后的有效范围内搜索到的下一个脉搏波与相应心跳象征信号的间距值加入间距数组,将间距数组的间距值进行排序,寻找与数组内的其他间距值两两相差小于设定差值最多的间距值的集合,用集合内间距值的平均值更新参考延迟值检测模块中的参考延迟值。 12. The pulse wave detecting apparatus according to claim 10 or claim 11, characterized by further comprising: a reference delay value updating module, configured to search within the effective range of the retardation value of the reference delay signal in a symbol of the heartbeat pulse wave spacing value corresponding to a symbol of the heartbeat signals added pitch array, the array pitch of the pitch values ​​are sorted to find other values ​​within an array pitch difference twenty-two set smaller than the difference between the pitch of the set up value, a value within the set of pitch the reference value is updated reference detection delay value module.
  13. 13.一种电子血压计,包括:袖带,设置在身体的规定部位;气压控制模块,对袖带进行充气到一定的压力,使袖带压迫动脉,并能够逐渐放气;压力检测模块,检测所述袖带内的压力;脉搏波检测模块,检测脉搏搏动因受袖带压迫而产生的脉搏波信号;其特征在于还包括:心电信号检测模块,检测因心脏跳动所产生的心跳象征信号,并记录其出现的时刻;参考延迟值检测模块,检测脉搏波相对于心跳象征信号的参考延迟值;脉搏波搜索模块,用于在心跳象征信号延迟参考延迟值后的有效范围内搜索脉搏波;基准脉搏波计算模块,根据搜索出的脉搏波得到不同压力下的基准脉搏波;血压计算模块,根据得出的压力序列和基准脉搏波序列,采用比率法计算平均压、收缩压和舒张压。 13. An electronic sphygmomanometer comprising: a cuff, provided in a predetermined portion of the body; pressure control module, the cuff is inflated to a certain pressure, the cuff artery compression, and can be gradually deflated; the pressure sensing module, detecting the pressure in said cuff; pulse wave detection module, detecting pulsation due to pulse compression cuff pulse wave signal produced; characterized by further comprising: electrocardiographic signal detection module, detecting the heartbeat by heartbeat symbol generated signal, and records the time of occurrence thereof; reference delay value detection module, detecting a pulse wave with respect to the reference symbol of the retardation value of the heartbeat signal; wave pulse search module, the effective range for the reference delayed signal delay value in the search pulse heartbeat symbol wave; reference pulse wave calculating module, the reference pulse wave obtained at different pressures according to a search pulse wave; blood pressure calculation module, based on the pressure pulse wave reference sequence and the sequence obtained, using the method of calculating the ratio mean pressure, systolic and diastolic pressure.
  14. 14.一种电子血压计,包括:袖带,设置在身体的规定部位;气压控制模块,对袖带进行充气到一定的压力,使袖带压迫动脉,并能够逐渐放气;压力检测模块,检测所述袖带内的压力;脉搏波检测模块,检测脉搏搏动因受袖带压迫而产生的脉搏波信号;其特征在于还包括:心电信号检测模块,检测因心脏跳动所产生的心跳象征信号,并记录其出现的时刻;处理模块,用于检测脉搏波相对于心跳象征信号的参考延迟值,在心跳象征信号延迟参考延迟值后的有效范围内搜索脉搏波,根据搜索出的脉搏波得到该压力下的基准脉搏波,根据得出的压力序列和基准脉搏波序列,采用比率法计算平均压、收缩压和舒张压。 14. An electronic sphygmomanometer comprising: a cuff, provided in a predetermined portion of the body; pressure control module, the cuff is inflated to a certain pressure, the cuff artery compression, and can be gradually deflated; the pressure sensing module, detecting the pressure in said cuff; pulse wave detection module, detecting pulsation due to pulse compression cuff pulse wave signal produced; characterized by further comprising: electrocardiographic signal detection module, detecting the heartbeat by heartbeat symbol generated signal, and records the time of occurrence thereof; processing module, searches the pulse wave within the effective range for detecting a pulse wave with respect to the reference symbol of the retardation value of the heartbeat signal, delayed reference symbol delay value in the heartbeat signal, the search pulse wave obtained at the reference pressure pulse wave based on the pressure pulse wave reference sequence and the sequence obtained, using the method of calculating the ratio mean pressure, systolic and diastolic pressure.
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