CN1938589B - Method and apparatus for implementing threshold based correction functions for biosensors - Google Patents
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Abstract
A biosensor system, method and apparatus are provided for implementing threshold based correction functions for biosensors. A primary measurement of an analyte value is obtained. A secondary measurement of a secondary effect is obtained and is compared with a threshold value. A correction function is identified responsive to the compared values. The correction function is applied to the primary measurement of the analyte value to provide a corrected analyte value. The correction method uses correction curves that are provided to correct for an interference effect. The correction curves can be linear or non-linear. The corrction method provides different correction functions above and below the threshold value. The correction functions may be dependent or independent of the primary measurement that is being corrected. The correction functions may be either linear or nonlinear.
Description
Technical field
Generally speaking, the present invention relates to biology sensor, more specifically, relate to a kind of method and apparatus, its be used to realize to be used for biology sensor, based on the correction function of threshold value.
Background technology
It is very important in diagnosis physically different to some and maintenance that analysans in the body fluid is carried out quantitative measurement.For example need to monitor lactic acid, cholesterol, cholerythrin in some individuality.Particularly, for glucose level in its body fluid of needs running check,, be very important to determination of glucose in the body fluid to regulate the diabetic individual that its meals glucose is taken in.Though the remainder of the open text of the application will should be appreciated that operation of the present invention and equipment can be used to measure other analysans on the basis of selecting suitable enzyme to determination of glucose.The desirable diagnostic device that glucose detects in the convection cell should be simple, to the part technician's that carries out this chemical examination the technical merit high request that do not have.Therefore under many circumstances, these chemical examinations are undertaken by the patient, more need to be easy to the chemical examination of carrying out.In addition, this kind equipment should be enough to the long-time composition of preserving based on being stabilized to.
The method that is used for measuring the fluid analyte concentration can and be specific to the analysans of this enzyme and this enzyme be remained electrochemical reaction between the medium (mediator) of its initial oxidation attitude based on enzyme.Suitable oxidoreducing enzyme comprises: oxidase, dehydrogenasa, hydrogen peroxidase (catalase) and peroxidase.For example, be under the situation of analysans when glucose, the reaction between glucose oxidase and the oxygen is by equation (A) representative.
(A)
In colorimetric test, exist under the situation of peroxidase, the hydrogen peroxide that discharges causes the redox indicator change in color, wherein, the proportional relation of glucose level in change color and the test fluid flow.Although by using color table that the change color of redox indicator and change color with the test fluid flow acquisition of known glucose concentrations are compared, thereby when carrying out to sxemiquantitative the colorimetric chemical examination, thereby and can be when reading result's higher level ground with spectrophotometric equipment and quantitatively carry out the colorimetric chemical examination, its result result that both electrochemica biological sensor of no use had obtained usually is accurate, and is also rapid not as the latter.Term used herein " bio-sensor system " refers to a kind of analytical equipment, it is to the analysans selective acknowledgment in the suitable sample, change its concentration into electric signal, this is that combination by bio-identification signal and physical-chemical transducer (transducer) realizes.
H
2O
2→O
2+2H
++2e
-
(B)
Then electric current is converted into the electric signal directly related with concentration of glucose.
In the initial step of the reaction that equation (A) is represented, the glucose that exists in the specimen is converted into its reduction form (FADH with oxidized flavin adenine dinucleotide (FAD) (FAD) center of enzyme
2).Because these redox centers substantially all are electrical isolation in the enzyme molecule, thus under the situation that does not have unacceptable too high voltages, just can not take place any reach can be measured degree, shift to the direct electron on traditional electrode surface.Improvement to this system comprises, uses the redox coupling of non-physiologic between electrode and enzyme, with at (FADH
2) and electrode between the electronics that shuttles back and forth.This is represented by following flow process, and wherein, redox couplant (coupler) (typically, being called as medium) is by the M representative:
Glucose+GO (FAD) → glucose lactone+GO (FADH
2)
GO(FADH
2)+2M
OX→GO(FAD)+2M
red+2H
+
2M
Red→ 2M
O *+ 2e
-(on electrode)
In this flow process, GO (FAD) represents the oxidised form of glucose oxidase, GO (FADH
2) represent its reduction form.Play the material M of medium effect
RedElectronics is shuttled back and forth to electrode from the enzyme that is reduced, and this enzyme of oxidation causes its in-situ regeneration thus, and with regard to the former of economic aspect thereby speech, yes that people want for this.The fundamental purpose of working medium is to reduce the work potential of sensor.Ideal medium can oxidized reduction on electrode under low potential, and under described low potential, impurity in the chemosphere and the obstruction material in the sample will can be not oxidized, makes minimum interference thus.
Because can accept electronics and they are transferred to electrode from the enzyme that is reduced, a variety of compounds all can be used as medium.The known medium that can be used as electron transfer agents in assay determination is disclosed substituted benzoquinones or naphthoquinones in the U.S. patent 4,746,607; N-oxide, nitroso compound, azanol and oxine (oxines) specifically are disclosed among the EP 0 354 441; Disclosed flavine among the EP 0 330 517, azophenlyene, phenothiazine, indophenols, substituted 1,4-benzoquinones and indamines; And the azophenlyene/phenoxazine salt of describing in the U.S. patent 3,791,988.For the summary of electrochemical mediators in the biological oxidation system, can referring to
Analytica ClinicaActa.140 (1982), Pp1-18.
More famous medium is six cyano group ferrites (hexacyanoferrate), and it is also referred to as the ferricyanide,
Deng the people,
Clinica Chimica Acta., 57 (1974), discuss to some extent among the Pp.283-289.In U.S. patent 4,929,545, disclose the purposes that a kind of soluble ferricyanide compound and soluble iron containing compounds combine in composition, be used for the sample analysans being measured by enzyme.Oxygen with in the molysite replacement equation (A) of the ferricyanide provides following equation:
Because accepted the electronics from glucose oxidase, the ferricyanide is reduced to ferrocyanide.
Another path of expressing this reaction can be represented with following equation C
Glucose+GO
X (OX)→ glucose lactone+GO
X (red)
GO
X(red)+2Fe(CN
3)
3- 6→GO
X(OX)+2Fe(CN)
4-+2e
-
(C)
The electronics that discharges directly is equivalent to the amount for the treatment of glucose in the fluid measured, can be by the electric current that produces in fluid applying voltage on the fluid be measured, the electronics of described release is shut away mutually with the amount of described glucose.The oxidation of ferrocyanide on anode makes this circulation upgrade.
Announce in the people's such as Huang on May 21st, 2002 U.S. patent 6,391,645 and be transferred to this assignee, wherein disclose a kind of method and apparatus, be used for proofreading and correct the influence of biology sensor environment temperature.It has measured the value of environment temperature.Sample application to biology sensor, is measured the electric current that produces in the testing sample then.By the standard response curve, calculate the value of observable analyte concentration from electric current.Revise observable analyte concentration with the ambient temperature value that records then, increase the degree of accuracy for the treatment of analyte determination thus.Can calculate the concentration of analysans by separating following equation:
G2＝(G1-(T
2 2-24
2)＊12-(T
2-24)＊11)/
((T
2 2-24
2)＊S2+(T
2-24)＊S1+1)
Wherein, G1 is described observable analyte concentration value, T
2Be the described ambient temperature value that records, I1, I2, S1 and S2 are preset parameters.
Though the method and apparatus of U.S. patent 6,391,645 provides the improvement for the degree of accuracy aspect of measuring analysans,, people still need to be used to measure the improved correction mechanism of any system of analyte concentration.
The term " biology sensor " that is used for following instructions and claims refers to the sensor module or the bio-sensor system of electrochemical sensor band (strip) or analytical equipment, it can be replied the making a choice property of analysans in the suitable sample, and changes its concentration into electric signal.Biology sensor directly produces electric signal, and this makes the design of instrument become simple.In addition, biology sensor also provides the advantage of low material cost, because the thin-layer chemical electrodeposition substance is only arranged to electrode, the material of waste seldom.
Term " sample " is defined as containing the composition of the target analysans of unknown quantity.Typically, the sample that is used for electrochemical analysis is a liquid form, and preferably, this sample is an aqueous mixture.Sample can be a biological sample, for example, and blood, urine or saliva.Sample can be the derivant of biological sample, for example, and extract, dilution, the precipitation that leaches thing or reconstitute.
Term " analysans " is defined as the material in the sample, and its existence or content are with determined.During the analysis, the oxidoreducing enzyme of analysans and existence interacts, its can be substrate, the coenzyme of oxidoreducing enzyme or have influence on oxidoreducing enzyme and its substrate between interactional another kind of material.
Summary of the invention
Importance of the present invention provides a kind of new, improved bio-sensor system, is used for the existence or the content of working sample material, and it comprises a kind of method and apparatus, be used to realize to be used for biology sensor, based on the correction function of threshold value.
In brief, the invention provides a kind of method and apparatus, be used to realize to be used for biology sensor, based on the correction function of threshold value.Sample application to biology sensor, is obtained the primary measurement values to analysans.Acquisition is to the secondary measured value of secondary influence, with itself and threshold.Determine and to make the correction function of replying to the value that is compared.Correction function is applied to the primary measurement values of analysans, the analysans value through overcorrect is provided.
According to feature of the present invention, calibration curve is used in bearing calibration, and it is provided to proofread and correct at interference effect.Calibration curve can be linearity or nonlinear.Bearing calibration provides the different correction functions above and below threshold value.Correction function can depend on or not rely on the primary measurement values that is being corrected.Correction function can be linearity or nonlinear.
According to feature of the present invention, the secondary measurement of secondary influence is comprised a large amount of influences, they can use separately or be used in combination together to determine correction function.For example, secondary influence comprises hematocrit (hematocrit) concentration of temperature, haemoglobin and blood sample, and it is determined, and is used to make the minimum interference of secondary influence to report result's degree of accuracy.
Description of drawings
From following detailed description to the preferred implementation of the present invention explained the accompanying drawing, can understand best and have the present invention above-mentioned and other purpose and advantage, wherein:
Fig. 1 is the structural drawing signal according to biological sensing system of the present invention;
Fig. 2 is a process flow diagram, and it has showed the example logic step of carrying out according to the present invention, and this is the step that is used to realize based on method threshold value, that secondary influence is proofreaied and correct, for example proofreaies and correct the influence of environment temperature in the bio-sensor system of Fig. 1; And
Fig. 3 and 4 is exemplary memory (stored) calibration curves, and it has been showed according to correction feature of the present invention.
Embodiment
With reference now to accompanying drawing,, Fig. 1 has shown the schematic configuration diagram of bio-sensor system, and described bio-sensor system integral body is by Reference numeral 100 representatives, and its principle according to the present invention is arranged.Bio-sensor system 100 comprises microprocessor 102, is connected with internal memory 104 on it, is used for stored routine and user data and calibration curve, described calibration curve be used to realize according to of the present invention, based on the correction to secondary influence of threshold value.Instrument function (meter function) 106 and biology sensor 108 couplings connection, it is operationally controlled by microprocessor 102, is used to write down laboratory values, for example the value of blood sugar chemical examination.ON/OFF input on the lead 110 responds to user's ON/OFF input operation, and itself and microprocessor 102 couplings join, and are used to move the blood testing ordered mode of bio-sensor system 100.System features input on the lead 112 responds to user's input operation, and itself and microprocessor 102 couplings join, and are used for optionally moving the system features pattern of biology sensor 100.The thermistor 114 that illustrates on the lead 116 provides the temperature signal input, and itself and microprocessor 102 couplings join, and are used to survey disturbing effect, for example, and according to the temperature information that is used for sensor 108 of the present invention.Signal input that illustrates on the lead 120 and microprocessor 102 couplings connection are used for that interfering material (for example haemoglobin) is carried out the second time and measure, and alternatively, are provided by instrument function 106.
Display 130 and microprocessor 102 couplings connection are used for the display message to the user, comprise result of laboratory test.Battery detection function 132 and microprocessor 102 couplings connection are used to survey battery condition low or that do not have.Warning function 134 and microprocessor 102 couplings connection are used to survey predefined system condition, and are used for the user of bio-sensor system 100 is produced the warning indication.FPDP or communication interface 136 also are provided, have been used for data are coupled to the computing machine (not shown) of connection, and from the computing machine that connects coupling connection data.Microprocessor 102 contains suitable procedure, is used to move method of the present invention, as shown in Figure 2.
Bio-sensor system 100 shows in simplified form, but is enough to understand the present invention.The bio-sensor system of showing 100 is not used in the restriction on hint structure or the function.The present invention can use with multiple hardwares implementation tool and system.
According to the present invention, the bearing calibration of biology sensor 100 operation preferred implementations for example, reduces temperature deviation, and it has as shown in table 1 below, and as common version that Fig. 2 explained and described.The invention provides a kind of algorithm bearing calibration, it has advantageously improved the degree of accuracy of diagnosis chemistry chemical examination, and this is by proofreading and correct secondary influence, and for example interfering material or temperature effect realize.
Be to be understood that, the present invention can be used to any system, electrochemical or optics, it measures analyte concentration as primary measurement values, (for example use then interfering material, haemoglobin) or the measured value second time of disturbing effect (for example, temperature) compensate secondary influence, and improve report result's degree of accuracy.
Making from erythrocytic volume fraction (volume fraction) or the hematocrit minimum interference for report result's degree of accuracy, also is that people want.The concentration of hematocrit is depended in the conductance of whole blood or impedance.Instrument function 120 can be used to the resistance of sample fluid on the measuring-signal incoming line 120, and measured value can be advantageously used at hematocrit report result's influence is proofreaied and correct.For example, the resistance that records can be advantageously used in the concentration of estimated blood sample of blood specific volume of cell, is used for then at the influence of hematocrit measured value being proofreaied and correct, to determine the concentration of target substance in the blood.The invention provides a kind of algorithm bearing calibration, it can advantageously improve the degree of accuracy of diagnosis chemistry chemical examination, and this realizes that by being proofreaied and correct at secondary influence described secondary influence comprises interference and the Temperature Influence from hematocrit.
According to the present invention, calibration curve is used in this algorithm bearing calibration, and for example, as institute's explaination in Fig. 3 and 4 and description, it can be suitable for the disturbing effect of any perfect establishment is proofreaied and correct.Calibration curve can be linearity or nonlinear.The algorithm bearing calibration has following feature: can come it is revised according to hereinafter described only changing equational coefficient.At first, can provide different correction functions above and below threshold value.The second, correction function can rely on or not rely on the primary measurement values that will be corrected.The 3rd, the function that is used to proofread and correct can be linearity or nonlinear.
Table 1: general correcting algorithm table
Step 1. obtains primary measurement values (Gn).
Step 2. obtains to be used to proofread and correct the secondary measured value of Gn (T)
If step 3A is T≤Tc, so:
1.A＝f(Gn)
2.C
n＝F＊T+A＊(Tc-T)+H
If step 3B is T〉Tc, so:
3.I＝f
2(G
N)
4.C
n＝F＊T+I＊(T-Tc)+H
5.G
c＝(G
N/G
n)
Wherein:
G
n=uncorrected analyte concentration measured value;
T=is used to proofread and correct the secondary measured value of primary measurement values;
T
c=commit point or threshold value, the secondary measured value that is higher or lower than threshold value advantageously can use different correction functions;
G
c=correction of a final proof result; And
A, I, F, H are control compensation line amplitude (magnitude) or the coefficient that limits calibration curve.
Referring now to Fig. 2, it has showed the example logic step of carrying out according to the present invention, and this is the step that is used to realize based on method threshold value, that secondary influence is proofreaied and correct, for example proofreaies and correct the influence of environment temperature in bio-sensor system 100.Shown in square 200, insert band (strip), wait until sample operation to be used then, shown in square 202.Shown in square 204, obtain primary measurement values Gn.Shown in square 206, obtain to be used to proofread and correct the secondary measured value T of Gn (T) then.Shown in decision piece 208, secondary measured value T is compared with threshold value Tc then.If secondary measured value T is less than or equal to threshold value Tc, shown in square 210, be identified for controlling the coefficient A of correction amplitude so, wherein, A=f (Gn).Then shown in square 210, calculated correction value Cn, wherein, Cn=F*T+A* (Tc-T)+H.Conversely,, shown in square 214, be identified for controlling the coefficient I of correction amplitude so if secondary measured value T is higher than threshold value Tc, wherein, I=f2 (Gn).Shown in square 216, come calculated correction value Cn then, wherein, Cn=F*T+I* (T-Tc)+H.Shown in square 218, calculate final correction Gc as a result, wherein, Gc=Gn/Cn is to finish correcting algorithm, shown in square 220.
With reference now to Fig. 3 and 4,, it has been showed respectively prevailingly by first and second example of Reference numeral 300 and 400 representatives, has wherein showed the exemplary Molded Line of proofreading and correct.In Fig. 3 and 4, number percent (%) is proofreaied and correct and is illustrated on the longitudinal axis, and secondary measured value T is illustrated on the transverse axis.Threshold value Tc is by the line representative that is marked with Tc.
Fig. 3 has showed appearance such as grade (isometric) correction under the different elementary measurement concentration Gn, and wherein corrected value depends on elementary measurement concentration Gn.Shown in example among Fig. 3 300, when secondary measured value T was higher or lower than threshold value Tc, the amplitude of corrected value Cn changed with analyte concentration Gn.Fig. 4 has showed the compensation line such as appearance such as grade under the different elementary measurement concentration Gn, wherein, under the situation that is higher than threshold value Tc, corrected value depends on elementary measurement concentration Gn, and under the situation of being less than or equal to threshold value Tc, corrected value is constant or do not rely on elementary measurement concentration Gn.
With reference to the details of the embodiments of the present invention of showing in the accompanying drawing, invention has been described, and these details are not limited to scope of the present invention, and scope of the present invention is shown in appended claim.
Claims (21)
1. method, be used to realize to be used for biology sensor, based on the correction function of threshold value, described method comprises following action:
Sample application to biology sensor, is obtained to treat the primary measurement values of analyte value;
Acquisition is to the secondary measured value of secondary influence;
Described secondary measured value and threshold with described secondary influence;
Respond to the described value that is compared, use at least one coefficient value to determine correction function, described at least one coefficient value depends on the described primary measurement values of described analysans value; And
The correction function that described warp is determined is applied to described primary measurement values, so that the analysans value through overcorrect to be provided.
2. the method for claim 1, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, describedly respond to the described value that is compared and determine that the action of correction function comprises following action: the described secondary measured value of determining described secondary influence is less than or equal to described threshold value, determine the first coefficient A, the described first coefficient A is used to control the amplitude of described correction function.
3. method as claimed in claim 2, be used to realize to be used for biology sensor, based on the correction function of threshold value, it also comprises following action: calculate the described correction function by following formula representative:
C
n＝F＊T+A＊(T
c-T)+H
Wherein, T represents the described secondary measured value of described secondary influence, and Tc represents described threshold value, and F, H are predefined coefficients.
4. method as claimed in claim 3, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, described definite correction function is applied to described primary measurement values and also comprises following action: calculate described analysans value through overcorrect by following formula representative so that the action through the analysans value of overcorrect to be provided
Gc＝Gn/Cn
Wherein, Gn represents the described primary measurement values of described analysans value.
5. the method for claim 1, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, describedly respond to the described value that is compared and determine that the action of correction function comprises following action: the described secondary measured value of determining described secondary influence is greater than described threshold value, determine coefficient I, described coefficient I is used to control the amplitude of described correction function.
6. method as claimed in claim 5, be used to realize to be used for biology sensor, based on the correction function of threshold value, it also comprises following action: calculate the described correction function by following formula representative
C
n＝F＊T+I＊(T-T
c)+H
Wherein, T represents the described secondary measured value of described secondary influence, T
cRepresent described threshold value, F, H are predefined coefficients.
7. method as claimed in claim 6, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, described definite correction function is applied to described primary measurement values and also comprises following action: calculate described analysans value through overcorrect by following formula representative so that the action through the analysans value of overcorrect to be provided
Gc＝Gn/Cn
Wherein, Gn represents the described primary measurement values of described analysans value.
8. the method for claim 1, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, describedly respond to the described value that is compared and determine that the action of correction function comprises following action: store predefined calibration curve, described predefined calibration curve is provided to proofread and correct disturbing effect.
9. the method for claim 1, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, describedly respond to the described value that is compared and determine that the action of correction function comprises following action: the described secondary measured value that responds to the described secondary influence that is less than or equal to described threshold value, determine the first coefficient A, and definite response is in the described correction function of the described definite first coefficient A.
10. method as claimed in claim 9, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, describedly respond to the described value that is compared and determine that the action of correction function comprises following action: respond to described secondary measured value greater than the described secondary influence of described threshold value, determine the second coefficient I, and definite response is in the described correction function of the described definite second coefficient I.
11. method as claimed in claim 10, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, determine the described first coefficient A and determine that the action of the second coefficient I comprises following action: the calibration curve of storage is provided, and described calibration curve has been represented the feature of the described secondary measured value of described secondary influence.
12. method as claimed in claim 10, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, definite response is in the described correction function of the described first coefficient A that is determined, and definite response comprises following action in the action of the described correction function of the described second coefficient I that is determined: determine the linear function at described correction function.
13. method as claimed in claim 10, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, definite response is in the described correction function of the described first coefficient A that is determined, and definite response comprises following action in the action of the described correction function of the described second coefficient I that is determined: determine the nonlinear function at described correction function.
14. the method for claim 1, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, obtain the action of the secondary measured value of secondary influence is comprised following action: obtain measured temperature.
15. the method for claim 1, be used to realize to be used for biology sensor, based on the correction function of threshold value, to be glucose and wherein said acquisition comprise following action to the action of the secondary measured value of secondary influence to wherein said analyte: obtain the hemoglobinometry value.
16. the method for claim 1, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, to be glucose and wherein said acquisition comprise following action to the action of the secondary measured value of secondary influence to described analyte: the measured value that obtains to show hematocrit concentration.
17. the method for claim 1, be used to realize to be used for biology sensor, based on the correction function of threshold value, wherein, described analyte is glucose and wherein obtains the action of the secondary measured value of secondary influence is comprised following action: obtain to show the measured value of hematocrit concentration and obtain measured temperature.
18. a device is used to realize the correction function based on threshold value, described device comprises:
Be used to obtain the biology sensor of sample;
With the processor of described biology sensor coupling connection, described processor responds to the described biology sensor that is used to obtain described sample, is used to obtain to treat the primary measurement values of analyte value;
Described processor is used to obtain the secondary measured value to secondary influence;
Described processor is used for the described secondary measured value and the threshold value of described secondary influence are compared;
Described processor responds to the described value that is compared, and uses at least one coefficient value to determine correction function, and wherein said at least one coefficient value depends on the described primary measurement values of described analysans value; And
Described processor is used for the described correction function that is determined is applied to described primary measurement values, so that the analysans value through overcorrect to be provided.
19. device as claimed in claim 18, be used to realize correction function based on threshold value, described device comprises: the calibration curve of storage, determine described correction function by described processor with it, and described calibration curve has been represented the feature of the described secondary measured value of described secondary influence.
20. device as claimed in claim 18, be used to realize correction function based on threshold value, wherein, described processor responds to the result who the described secondary measured value of described secondary influence is confirmed as being less than or equal to described threshold value, be used for determining the first coefficient A, the described first coefficient A is used to control the amplitude of described correction function.
21. device as claimed in claim 20, be used to realize correction function based on threshold value, wherein, described processor responds to described secondary measured value to described secondary influence and is confirmed as result greater than described threshold value, be used for determining the second coefficient I, the described second coefficient I is used to control the amplitude of described correction function.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55790704P | 2004-03-31 | 2004-03-31 | |
| US60/557,907 | 2004-03-31 | ||
| US60957004P | 2004-09-13 | 2004-09-13 | |
| US60/609,570 | 2004-09-13 | ||
| PCT/US2005/011077 WO2005098424A1 (en) | 2004-03-31 | 2005-03-31 | Method and apparatus for implementing threshold based correction functions for biosensors |
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| US8260556B2 (en) * | 2008-08-21 | 2012-09-04 | Bio-Rad Laboratories, Inc. | Calibration surface method for determination on of analyte ratios |
| JP5713465B2 (en) * | 2012-09-14 | 2015-05-07 | 株式会社タニタ | Biosensor calibration method |
| CN105378484B (en) * | 2013-03-14 | 2017-06-09 | 安晟信医疗科技控股公司 | The standardized calibration of analyte concentration determination |
| CN104750132B (en) * | 2015-04-21 | 2017-03-15 | 三诺生物传感股份有限公司 | A kind of test temperature bearing calibration, controller and test temperature correction system |
| FI128124B (en) * | 2016-04-25 | 2019-10-15 | Teknologian Tutkimuskeskus Vtt Oy | Optical sensor, system and methods |
| CN109682968B (en) * | 2018-11-08 | 2022-03-11 | 上海艾瑞德生物科技有限公司 | Temperature correction method for quantitative detection test signal of fluorescence immunoassay strip |
| CN114660149A (en) * | 2022-02-23 | 2022-06-24 | 爱奥乐医疗器械(深圳)有限公司 | Electrochemical test paper and detection method |
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| CN1412548A (en) * | 2001-10-10 | 2003-04-23 | 生命扫描有限公司 | Detection of proper sampling volume from biological sensor device |
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| CN1412548A (en) * | 2001-10-10 | 2003-04-23 | 生命扫描有限公司 | Detection of proper sampling volume from biological sensor device |
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