CN1913774A - 表达MEGSIN/RAGE/iNOS的疾病模型动物及借助于该动物评估化合物的方法 - Google Patents
表达MEGSIN/RAGE/iNOS的疾病模型动物及借助于该动物评估化合物的方法 Download PDFInfo
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Abstract
Description
小鼠品系 | HbA1c(%) | BW(g) | KW(g) | KW/BW | GLU(mg/dl) | 胰岛素(ng/ml) | BUN(mg/dl) | CRE(mg/dl) |
NDS(n=5)CD-1(n=6)meg/NOS/RAGE(n=8)RAGE/NOS(n=10)meg/NOS(n=5)meg/RAGE(n=10)meg(n=11)RAGE(n=11) | 7.2±1.36.5±1.67.6±1.35.9±2.7 | 43.5±3.343.1±8.833.1±6.5*145.3±3.435.6±5.7*340.2±10.244.2±11.448.5±7.3 | 1.08±0.15*30.72±0.140.98±0.321.11±0.19*30.86±0.310.65±0.140.69±0.170.71±0.17 | 0.025±0.003*10.017±0.0030.030±0.009*10.024±0.004*10.022±0.0060.016±0.0040.015±0.0020.014±0.004 | 858.0±200.8*1194.7±56.8682.6±373.8*1766.4±167.8*1699.6±390.9*1191.6±87.6225.9±64.8180.8±35.1 | 0.34±0.16*24.40±3.800.43±0.37*20.27±0.20*20.52±0.522.64±2.323.99±3.82 | 41.8±12.730.7±5.040.6±16.638.6±7.3*241.2±19.335.7±8.034.3±5.533.4±6.6 | 0.78±0.110.62±0.130.76±0.210.75±0.150.68±0.220.62±0.110.60±0.070.56±0.11 |
小鼠品系 | TP(g/dl) | TCH0(mg/dl) | TG(mg/dl) | GOT(U/I) | GPT(U/I) | ALB/CRE比 |
NOS(n=5)CD-1(n=6)meg/NOS/RAGE(n=8)RAGE/NOS(n=10)meg/NOS(n=5)meg/RAGE(n=10)meg(n=11)RAGE(n=11) | 3.8±0.34.4±0.34.2±1.64.7±2.24.0±0.54.7±0.94.9±1.74.3±0.3 | 146.2±17.2148.8±54.0145.5±29.3148.2±18.1151.6±31.8132.0±39.7161.4±35.6137.5±31.7 | 318.6±303.5169.0±88.2436.3±296.1388.3±258.3500.6±402.5224.5±122.6221.1±72.5190.5±105.2 | 90.2±37.2137.0±33.7149.3±34.0109.3±47.9*2105.4±32.5145.0±42.3140.0±79.0160.9±100.4 | 40.2±11.149.7±25.541.1±11.648.7±22.938.8±15.253.1±30.748.2±18.550.2±25.2 | 0.02±0.010.14±0.070.06±0.020.15±0.060.09±0.04-0.11±0.02 |
Claims (16)
Applications Claiming Priority (2)
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JP415779/2003 | 2003-12-12 | ||
JP2003415779 | 2003-12-12 |
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CN1913774A true CN1913774A (zh) | 2007-02-14 |
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CNA2004800414656A Pending CN1913774A (zh) | 2003-12-12 | 2004-12-09 | 表达MEGSIN/RAGE/iNOS的疾病模型动物及借助于该动物评估化合物的方法 |
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Country | Link |
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US (1) | US20080263683A1 (zh) |
EP (1) | EP1712125A4 (zh) |
JP (1) | JPWO2005055706A1 (zh) |
KR (1) | KR20060114713A (zh) |
CN (1) | CN1913774A (zh) |
CA (1) | CA2549482A1 (zh) |
WO (1) | WO2005055706A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103348012A (zh) * | 2010-11-27 | 2013-10-09 | 朱坚 | 一种人源化的转基因动物 |
CN107105632A (zh) * | 2014-11-10 | 2017-08-29 | 豪夫迈·罗氏有限公司 | 肾病动物模型及其治疗剂 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2947343C (en) * | 2005-09-16 | 2019-04-30 | Cornell Research Foundation, Inc. | Methods for reducing cd36 expression |
US8312486B1 (en) | 2008-01-30 | 2012-11-13 | Cinsay, Inc. | Interactive product placement system and method therefor |
WO2011044511A2 (en) * | 2009-10-08 | 2011-04-14 | The Trustees Of Columbia University In The City Of New York | Rage regulates rock activity in cardiovascular disease |
US11268950B2 (en) | 2016-09-28 | 2022-03-08 | Organovo, Inc. | Use of engineered renal tissues in assays |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP3956272B2 (ja) * | 1997-09-22 | 2007-08-08 | 敏男 宮田 | メグシンタンパク質 |
EP1224862A4 (en) * | 1999-10-06 | 2003-01-02 | Kurokawa Kiyoshi | ANIMAL MODEL FOR PROLIFERATIVE NEPHRITIS WITH MESANGIAL CELLS |
-
2004
- 2004-12-09 CN CNA2004800414656A patent/CN1913774A/zh active Pending
- 2004-12-09 JP JP2005516179A patent/JPWO2005055706A1/ja not_active Withdrawn
- 2004-12-09 US US10/582,655 patent/US20080263683A1/en not_active Abandoned
- 2004-12-09 EP EP04820285A patent/EP1712125A4/en not_active Withdrawn
- 2004-12-09 CA CA002549482A patent/CA2549482A1/en not_active Abandoned
- 2004-12-09 KR KR1020067013911A patent/KR20060114713A/ko not_active Application Discontinuation
- 2004-12-09 WO PCT/JP2004/018413 patent/WO2005055706A1/ja active Application Filing
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103348012A (zh) * | 2010-11-27 | 2013-10-09 | 朱坚 | 一种人源化的转基因动物 |
CN103348012B (zh) * | 2010-11-27 | 2016-06-08 | 朱坚 | 一种人源化的转基因动物 |
CN107105632A (zh) * | 2014-11-10 | 2017-08-29 | 豪夫迈·罗氏有限公司 | 肾病动物模型及其治疗剂 |
Also Published As
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KR20060114713A (ko) | 2006-11-07 |
WO2005055706A1 (ja) | 2005-06-23 |
CA2549482A1 (en) | 2005-06-23 |
EP1712125A1 (en) | 2006-10-18 |
JPWO2005055706A1 (ja) | 2007-12-06 |
EP1712125A4 (en) | 2009-06-10 |
US20080263683A1 (en) | 2008-10-23 |
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