CN1903117A - Non penetration type system for measuring radial artery blood pressure wave and its application - Google Patents

Abstract

A non-invasion system for measuring the blood pressure and waveform of arteria radialis on wrist of hand is disclosed. It can be used to monitor blood pressure, variation of cardiac rhythm, automatic nerve function, the waveform and frequency of respiration, cough, sneeze, etc and recognize the identity of person.

Description

Non penetration type system for measuring radial artery blood pressure wave and application thereof

Technical field

The present invention relates to a kind of measurement system and application thereof, relate in particular to and to be applicable to the measurement heart rate variability simultaneously, measure the autonomic nerve function, the personal identification identification, breathe wave mode and cough and detect side, house quarantine, and a kind of piezoelectric inductor of utilizing of the isolated purposes of hospital is to measure the Noninvasive instrument system of wrist radial artery blood pressure wave mode.

Background technology

Heart rates and blood pressure (systolic pressure and diastolic pressure) are important human body physiological parameter, generally measure and obtain with existing wrist formula or arm-type electric sphygmomanometer, because easy and simple to handle and reasonable price, become one of herbal medical device, but another important physiological parameter, be the blood pressure wave mode, the accuracy height is not then arranged yet, instrument system easy and simple to handle can be utilized now.

Electric sphygmomanometer on the market only can measure and show systolic pressure (Systolic Blood Pressure, i.e. maximum on the blood pressure ripple) and diastolic pressure (Diastolic Blood Pressure, i.e. minima on the blood pressure ripple) at present.

Existing wrist formula electric sphygmomanometer contains an air pump of inflating usually, a gas bleeder valve, a barometer, an airway, a wrist strap that includes airbag, a circuit module, and a shell.In the blood pressure measuring process, air pump and gas bleeder valve cause airbag pressurization and decompression, blood pressure pulse wave in this while wrist radial artery sees through airbag and is sent to barometer, software and hardware on the circuit are amplified barometrical pulse wave signal again, filter and analyze and calculate heart rates (HeartRate), systolic pressure (Systolic Blood Pressure) and diastolic pressure (Diastolic Blood Pressure).

Except heart rate, systolic pressure reaches outside the diastolic pressure on the physiology, and accurate arteriotony wave mode also is an important physical parameter, repeats after its many clinical practice is held.Though above-mentioned being somebody's turn to do has the blood pressure wave mode that the sphygomanometer measurement technology can be write down radial artery by barometer now, but because factors such as airbag material behavior and geometry, the original shape of blood pressure ripple can't be passed in the air of airbag fully, add from airbag and reach the barometrical path through airway, the wave mode generation passivation (Dampening) and the strength reduction of blood pressure ripple cause measured blood pressure wave mode to lose sensitivity (Sensitivity) and accuracy (Accuracy).For recording more accurate radial artery blood pressure wave mode, pulse-taking instrument on the market adopts the round pressure inductor of an about 5-mm diameter, earlier this round pressure inductor is fixed in wrist radial artery top with adhesive tape or rubber band during test, again its Communication signal wire is connected to circuit board or computer, usually this round pressure inductor is that resistance-type (Resistor-type) conductive material is formed, similar with the principle of stressor (Strain Gauge), contain amplifying circuit, the temperature effects compensation reaches elements such as linearization process.When the resistance material pressurized, resistance, electric current, or the change amount and the pressure of voltage are proportional, therefore relation record pressure by this.Above-mentioned technology really can record the details and the original shape of radial artery blood pressure wave mode under ideal state, but its shortcoming is for can't accurately control the pressure that round pressure inductor is fixed in the wrist surface.

Find after tested, the pressure that round pressure inductor is fixed in the wrist surface is quite important for measuring the blood pressure wave mode, if this pressure kicks the beam (for example above-mentioned prior art is only fixed with adhesive tape or rubber band), then run into the wrist plumpness, the radial artery deepness, or during situation such as pulse wave is thin and delicate, pressure inductor just can't be obtained blood pressure wave mode signal clearly.If this pressure is overweight, then the blood flow of radial artery is subjected to serious Zu Rao, causes the blood pressure wave mode distortion that records.In addition, because factors such as wrist shape size and position of radial artery deepness just can find the tremulous pulse tram after this round pressure device must be felt the pulse with finger by trained doctor or nursing staff, fixed.The operational inconvenience of this kind is that pulse-taking instrument or other similar equipment can't become one of factor of house medical device as electric sphygmomanometer.

Secondly, existing personal identification identification technique is existing multiple, comprises the image of face analysis, the identification of sound sound, and identification of fingerprint, the blood group analysis, the eyes position is analyzed, the hair analysis, graphology analysis, and more advanced DNA cell identification and analysis etc.The inventor via experiment finder intravital arteriotony wave mode because of everyone heart shape size, myocardial structural, and difference such as tree-shaped tremulous pulse (Arterial Tree) organizational structure, the unique single characteristic of tool can be used as the feature of personal identification identification.Though the arteriotony wave mode is sometimes because of factors such as emotion and environment (palpitating speed when for example nervous or angry, hypertension) changes, but as long as with the blood pressure wave mode to the in addition standardization (Normalization) of heart beating value and pressure value, then the feature of wave mode just tends towards stability and becomes personalized features.

Measure at present heart rate variability (Heart Rate Variability, HRV) and the autonomic nervous system function (AutonomicNervous System, reference instrument ANS) are electrocardiograph (Electrocardiograph, ECG, or claim EKG in addition).So-called heart rate variability means the speed (being heart rate) of heartbeat, maintains about 60-90 time of the per minute except static state is constant, has wherein also hidden some regular or irregular fluctuations.When measuring heart rate and variability thereof with electrocardiograph, earlier electrode slice is affixed on patient's trick (and chest), measure the electrocardio signal of its consecutive periods, to measure again the ripple-wave space in the electrocardio fluctuation (as the R-R spacing, the R peak is the summit in the electrocardio ripple) calculate, just can further calculate the parameters value of heart rate and heart rate variability with the ordered series of numbers of the ripple-wave space of this gained.For example, the meansigma methods of the ordered series of numbers of ripple-wave space is heart beat cycle (Period), the inverse of heart beat cycle be heart rate (Heart Rate, HR); The standard deviation of the ordered series of numbers of ripple-wave space (StandardDeviation) is heart rate variability (Heart Rate Variability), and the ordered series of numbers data of ripple-wave space also can utilize quick Fu Lier transformation approach (Fast Fourier Transform) to convert frequency spectrum to.Plant the assistance of spectrum analysis thus, the total degree of variation in the heart rate variability (Total Power) can be divided into two kinds of compositions, is commonly referred to as high frequency (High Frequency, 0.15-0.4Hz, HF) composition and low frequency (Low Frequency, 0.04-0.15Hz, LF) composition.People (Hemodynamic Fluctuationsand Baroreflex Sensitivity in Humans:A Beat-to-Beat Model. such as De Boer; American Journal of Physiology; 253:H680-H689; 1987) via animal and human experimentation, confirm heart rate variability (Heart Rate Variability, be the standard deviation of the ordered series of numbers of aforementioned peak-peak spacing) and total degree of variation (Total Power) represent the autonomic nerve gross activity, the low frequency composition is represented sympathetic nerve function, the high frequency composition is represented parasympathetic functions, and the ratio (LF/HF) of low frequency composition and high frequency composition has then reacted the autonomic nerve degree of balance.Because autonomic nerve is controlled the multinomial conscious or automatic key activities of human body, for example: heart beating, blood pressure, blood glucose, sleep, sweat and bronchus actuates etc., medically the utmost point needs an autonomic nerve function monitor easy and simple to handle, cheap.Medical circle uses electrocardiograph to measure heart rate variability and autonomic nerve function at present, not only trivial operations (large-scale instrument, special software, the a plurality of electrode slices of paving, the testee action is restricted etc.), and cost higher (initial stage instrument and software expense, follow-up training and electrode slice expense).

When a personal breathing, because breathing the signal at center (Respiratory Center), the human body brain overflows biography (Spillover) to the cerebral vessels center (Vasomotor Center), this citation of overflowing number sees through feedback (Reflex) mechanism of autonomic nerve (sympathetic nerve (Sympathetic Nerve) and parasympathetic nervous (Para-Sympathetic Nerve)), cause heart rate and cardiac contractile force to increase regularly and minimizing along with the breathing cycle, therefore accurately write down the arteriotony wave mode, and further calculate and analyze changes in heart rate, just can detect respiratory frequency and wave mode.In addition, crest of the arteriotony point of systolic pressure (promptly corresponding to) and the trough point of diastolic pressure (promptly corresponding to) also can the liftings along with the breathing cycle, just medically alleged arteriotony respiratory wave (Arterial Respiratory Waves).Overflow except above-mentioned breathing center signal the factor that passes in the source of this blood pressure respiratory wave, also comprise two physiology mechanisms in addition: when (1) is air-breathing, diaphragm (Diaphragm) descends, present negative pressure, blood vessel is back to the minimizing of heart flow in the thoracic cavity, causes heart output (Cardiac Output) to reduce and blood pressure moment reduction; (2) the pressure variation takes place in blood vessel in the thoracic cavity because of diaphragm moves up and down, this changes via vascular pressure feedback mechanism (Baroreceptor Reflex), cause arteriotony lifting (above-mentioned physiological phenomenon and principle with respiratory frequency, see also " Textbook of MedicalPhysiology ", Authored by Arthur C.Cuyton, Eighth Edition, W.B.Saunders Company, ISBN0-7216-3087-1,1991, Chapter 13).As from the foregoing, by accurately writing down the arteriotony wave mode, can analyze the lifting of crest or trough, and obtain respiratory frequency and wave mode.

Also have the prevention of infectious disease and medical treatment and nursing, a very important ring in the medical system of can saying so.With serious acute respiratory syndrome (the Severe Acute Respiratory Syndrome that wreaks havoc the Asia in recent years, SARS) be example, because the route of infection are behaved and to be seen through air medium with the human world and infect, therefore patient and other people isolation are become the available strategy of epidemic prevention.How other infectious diseases no matter be to see through air (as pulmonary tuberculosis) or blood and body fluid (AIDS AIDS etc.) to infect, reduce patient (or suspicious patient) and medical personnel or household's close contact, one of the current medical profession key subjects of can saying so.More go deep into one deck analysis, aspect hospital's isolation and monitoring, the standard step of hospital is to enter isolation ward by medical personnel every day to measure body temperature at present, heart beating and blood pressure be (for example four times on the one) for several times, and observation patient symptom (if any apnea difficulty and cough etc.), this kind monitoring demand often is the main cause that medical personnel are infected.Therefore, can be spread out of to the nursing station by isolation ward automatically, then can reduce medical personnel's contact infection source if isolate the physiological signal of sufferer.In general infectious disease, disease the levying of mainly falling ill comprises fever, cardiopalmus, rapid breathing, cough, sneeze, dysarteriotony etc.If can be in conjunction with the non-intrusion type hands radial artery blood pressure wave mode technology among the present invention, existing body temperature measurement technology, and existing wireless or wired signal transmission technology, carried wrist formula physiological monitor of the present invention (being detailed later) as long as then isolate sufferer, just physiological signal (can be comprised body temperature, heart beating, blood pressure, breathe wave mode, whether cough etc.) spread out of the ward, and reach the target that reduces close contact.

Aspect the house quarantine monitoring, the opinion with the epidemic prevention experience of various countries SARS in recent years, the maximum leak of epidemic prevention is to need voluntarily according to regulation, and the common people of house quarantine go out in violation of rules and regulations.Another technical need of house quarantine is obtained the physiological signal of being isolated the common people for regular (as every day), and grasps whole epidemic situation development at any time.The practice of various countries health office is to send someone to investigate to isolating in the common people family at present, yet this measure not only needs a large amount of manpowers, and comes in contact infection easily.If can be in conjunction with (1) of the present invention non-intrusion type wrist formula blood pressure wave mode measurement technology, (2) personal identification identification technique, (3) breathe the wave mode technology, and (4) cough detection techniques; And existing (1) body temperature measurement technology, (2) wireless or wire transmission technology, and (3) blood pressure measuring technology, just can be regularly with isolated the common people physiological signal (as body temperature, heart beating, blood pressure, whether cough etc.) from family, reach hospital or health competent authority, and can prevent these common people go out in violation of rules and regulations (and can't substitute etc.), and further add up number of the infected and place thereof at any time, thereby control epidemic situation with other people.

As mentioned above, when people's eupnea, the blood pressure wave mode presents moving up and down of periodicity.But if when this people cough suddenly or sneeze, sharply shake, cause the promptly irregular variation of blood pressure wave mode, and when coughing or sneeze when stopping, the blood pressure wave mode is recovered normal condition again because of diaphragm and thoracic cavity.If can and change (Abrupt Change) suddenly by the blood pressure wave mode datum line (Baseline) of analyzing personal, should predict the symptom whether testee has cough or sneeze.

No. 363404 patent of TaiWan, China discloses utilizes analysis of heart rate variability electrocardio transducer (including electrode slice), measure the current potential signal that is sent when heart of patient shrinks, calculate rhythm of the heart variability with Fu Lier transformation approach (Fourier Transform) and spectrum analysis again, yet the purpose of this invention is to provide a kind of novel analysis of heart rate variability electrocardio transducer, and it is characterized in that the design and the instrument system of novel software and hardware.

No. 176323 patent of TaiWan, China discloses utilize Noninvasive autonomic nervous system monitoring instrument system measurements to take medicine autonomic nervous system side effect and monitoring human degree of aging or therapeutic effect that patient causes.

All do not disclosed the instrument system that is used for accurately measuring wrist radial artery blood pressure wave mode as Noninvasive novel piezoelectric induction apparatus of the present invention in the aforementioned prior art.Also do not disclose in the aforementioned prior art or advise utilizing Noninvasive novel piezoelectric induction apparatus of the present invention as measuring heart rate variability, measure the autonomic nerve function, the personal identification identification is breathed wave mode and cough detecting, house quarantine, and the isolated purposes of hospital.

Summary of the invention

Primary and foremost purpose of the present invention overcomes above-mentioned technology and operating difficulties exactly, and development one cover non-intrusion type is easy and simple to handle, and can accurately measure the instrument system of wrist radial artery blood pressure wave mode.

Another object of the present invention is to utilize this non-invasion blood pressure wave mode technology to measure mean pressure in the blood pressure, its can accurately measure the blood pressure wave mode, utilize the integration and the existing measured systolic pressure and the diastolic pressure of electric sphygmomanometer of blood pressure wave mode-time diagram, but joint account goes out mean blood pressure.

Another object of the present invention is and utilizes this kind non-intruding, processing ease, and price is low, the wrist radial artery blood pressure wave mode measuring instrument system that accuracy is high, the rhythm of the heart variability and the autonomic nerve function of coming monitoring human.

Another object of the present invention is to utilize the measuring instrument system of this non-invasion blood pressure wave mode, as the application of personal identification identification.

Another object of the present invention reaches the target of the physiological parameter of monitoring respiratory frequency and wave mode for utilizing this non-invasion blood pressure wave mode measurement technology.

Another object of the present invention need not leaned on person to person's close contact for development one cover non-intrusion type, just can carry out hospital infectious disease and suffer from the instrument system of isolating with monitoring.

Another object of the present invention is to utilize this non-invasion blood pressure wave mode measuring instrument system, reach the target of monitoring cough or sneeze.

Another object of the present invention is applicable to the monitoring house quarantine common people's instrument system for development one cover non-intrusion type.

The following technological means of employing of the present invention realizes:

A kind of non penetration type system for measuring radial artery blood pressure wave comprises: one in order to measure the wrist radial artery, and the piezoelectric inductor of the electric wave of blood pressure pulse wave is represented in its energy continuous record and generation; One its contain airbag, can wear on human body wrist, and the wrist strap that aforesaid piezoelectric inductor is exerted pressure; One can be to the air pump of aforesaid airbag inflation; One is connected with in the gas bleeder valve of one of airbag end; One is connected to the airway of airbag; One includes central computer, and memory body is provided with the circuit module of operating software in it; One is connected in the barometer of the airway of airbag; One power supply, and one can contain the instrument host of receiving wherein with aforementioned portion of element.

The following technological means of the passable employing of the present invention realizes:

Aforesaid piezoelectric inductor can be ceramic Lead zirconate titanate (PZT) piezoelectric patches, or macromolecule polyvinylidene fluoride (PVDF) piezoelectric patches, or stress type (Strain Gauge) piezoelectric element, or semi-conductor type (Semi-Conductor) silicon piezoelectric element.

It is one round that the induction main body of aforesaid piezoelectric inductor can be, and square is other geometric thin slices, and its thickness can be from scopes such as 0.1mm to 5mm, and its diameter or the length of side can be from scopes such as 1mm to 100mm.

Aforesaid piezoelectric inductor is the elongated thin slice, and is to place wrist strap, the one side of its thin slice contacts with airbag in the wrist strap, and another side then contacts with the outer layer cloth of wrist strap, when test, only need wrist strap and banded instrument host thereof are worn in the wrist top, can test.

Aforesaid piezoelectric inductor can be formed a piezoelectricity inductive module by a plurality of (at least two) piezoelectric element, and be built in the wrist strap, wherein each element is a rectangle (or circular) piezoelectric sheet, and its length of side (or diameter) is 3～5mm, and the substrate of inductive module is a flexible circuit board (soft printed circuit board), combination step is for to form a line a plurality of piezoelectric elements according to the hands cross direction, be fixed on the flexible circuit board, then have one in the middle of element and the element to avoid the slight void (0.1～1mm) of contiguous wave interference.

Aforesaid circuit module installs the multiple signals scanning device (Multi-Plexer) and the associated drives software that are connected to filtration and amplifying circuit again from the electric wave signal of each sensing element to receive additional.

A kind of application of non penetration type system for measuring radial artery blood pressure wave, it measures the use step of the physiology mean blood pressure (Physiological Mean Blood Pressure) in the blood pressure: record systolic pressure (SBP) and diastolic pressure (DBP) with electric sphygmomanometer concussion technology (Oscillometric Method); Measure the blood pressure wave mode, and with X-Y plane mapping (Fig. 7), wherein Y-axis is relative magnitude of voltage V, X-axis is actual time t; The relative voltage meansigma methods V (mean) of the above-mentioned blood pressure wave mode that records is calculated with following formula:

-----------(1) of V (mean)=V-t integrated value/(t2-t1)

Wherein V (mean) is the relative voltage meansigma methods, and the V-t integrated value is the V-t mode chart in the integrated value of t1 (wave mode starting point) to the scope of t2 (wave mode end point), and t2-t1 is the time interval of single wave mode, calculates the physiology mean blood pressure according to following formula:

PMBP＝V(mean)*(SBP-DBP)/(VS-VD)-------(2)

Wherein PMBP makes a living and pats equal blood pressure, and V (mean) is the relative voltage meansigma methods, and SBP is a systolic pressure, and DBP is a diastolic pressure, and VS is the maximum (crest) of blood pressure wave mode, and VD is the minima (trough) of blood pressure wave mode;

Physiology mean blood pressure PMBP according to following formula is calculated each blood pressure wave mode, average these a plurality of PMBP again:

PMBP(mean)＝SUM(PMBP)/N---------(3)

Wherein PMBP (mean) makes a living and pats the meansigma methods of equal blood pressure PMBP, and SUM (PMBP) is the summation of N PMBP, and N is the number of blood pressure wave mode.

A kind of application of non penetration type system for measuring radial artery blood pressure wave, it measures the identity step of breathing wave mode and frequency:

(as 1～10 minute) captures the blood pressure wave mode of testee continuously and makes X-Y figure in the testing period, and wherein the X value is the time, and the Y value is voltage or pressure; Find out the X value (being time value) and Y value (being voltage or force value) of the main wave crest point of each wave mode; Make continuous XY figure, as the breathing wave mode of this testee; Every regularly (as one minute) interior wave mode number (as eight) is calculated, and is respiratory frequency or Respiration Rate (as each minute eight breathings).

A kind of application of non penetration type system for measuring radial artery blood pressure wave, the symptom step of its monitoring cough or sneeze:

Capture the blood pressure wave mode of testee continuously; Calculate testee three parameter values (time interval of promptly main crest-main crest of the blood pressure wave mode of interior (as a minute) in the early stage, the force value of main crest value, and the force value of main trough) meansigma methods and standard deviation, and with the meansigma methods definition datum line of three parameter values for this reason; At any time monitor three parameter values of blood pressure wave mode at test period, if one of them departs from (containing above) more than the prior prearranged multiple (for example three times) of its datum line accurate deviation up to standard, then this wave mode is called suspicious irregular material point; With irregular material point (do not have certain frequency) taking place at random, defines this material point and be cough or sneeze point; Statistics can obtain cough or sneeze frequency (as per minute three times).

Aforesaidly be used for the novel physiological signal monitoring instrument system that hospital isolates sufferer, wherein the body temperature measurement technology can use a low profile thermal galvanic couple, a resistance-type electronic component, or an infrared ray electric device, the three is all thermal sensible element, body temperature can be converted to voltage or current signal.

Aforesaidly be used for the novel physiological signal monitoring instrument system that hospital isolates sufferer, Radio Transmission Technology wherein can be used RF (Radio Frequency) wireless module of general commercialization, and its frequency range can be in ISM Band (i.e. [industry commonly used, science, medical treatment] band sharing).

Compared with prior art have remarkable advantages and beneficial effect:

The present invention regularly reaches the signal receiving and analyzing device of putting in family with the physiology information that has Radio Transmission Technology to incite somebody to action; With signal receiving and analyzing device the physiology information is stored, analysis regularly reaches health office with the Internet (Internet) transmission or phone data machine (Modem) after (or demonstration); Regularly collect, arrangement, and not morbidity of statistics are fallen ill, and restorative isolation common people number.

Description of drawings

Fig. 1 is a system block chart of the present invention;

Fig. 2 uses the induced enforcement illustration of piezoelectricity for the present invention;

Airbag air pressure and time relation figure when Fig. 3-1 uses for the present invention;

Blood pressure waveform signal and air pressure graph of a relation when Fig. 3-2 uses for the present invention;

Hands Wrists radial artery blood pressure mode chart when Fig. 3-3 uses for the present invention;

Fig. 4 implements illustration for the present invention uses induced another of piezoelectricity;

Piezoelectricity is induced one implements illustration to Fig. 5 again for the present invention uses;

Fig. 6 uses the induced another enforcement illustration of piezoelectricity for the present invention;

Fig. 7 is the present invention's operation software action flow chart;

Fig. 8 measures the sketch map of mean blood pressure with the blood pressure pulse wave for the present invention;

Radial artery blood pressure wave mode one exemplary view of Fig. 9-1 for using the present invention to record;

Fig. 9-2 another exemplary view of radial artery blood pressure wave mode for using the present invention to record;

Fig. 9-3 is the radial artery blood pressure wave mode using the present invention and a record exemplary view again;

The continuous blood pressure wave mode sketch map of Figure 10 for using the present invention to record;

The breathing wave mode sketch map of Figure 11 for using the present invention to record;

Figure 12 another breathing wave mode sketch map for using the present invention to record;

Figure 13 utilizes blood pressure wave mode detecting cough and sneeze sketch map for using the present invention;

Figure 14 is used in the monitoring system figure of hospital's isolation ward physiological signal for the present invention;

Figure 15 is used in the monitoring system figure of house quarantine common people physiological signal for the present invention;

Figure 16 is that of the present invention another uses sketch map;

The hands Wrists radial artery blood pressure mode chart of Figure 17 for using the present invention to record;

The first-hand Wrists radial artery blood pressure mode chart of Figure 18-1 for using the present invention to record;

The second-hand Wrists radial artery blood pressure mode chart of Figure 18-2 for using the present invention to record;

The three hands Wrists radial artery blood pressure mode chart of Figure 19 for using the present invention to record;

The four hands Wrists radial artery blood pressure mode chart of Figure 20 for using the present invention to record.。

The specific embodiment

Below just in conjunction with the accompanying drawings to structure function of the present utility model, in addition detailed explanation;

This kind non-intrusion type of the present invention is really measured the instrument system of wrist radial artery blood pressure wave mode, and as shown in Figure 1, it comprises:

(a) piezoelectric inductor 1 of measurement wrist radial artery, it can also produce the electric wave of representing the blood pressure pulse wave by continuous record;

(b) including the wrist strap 2 of airbag, is to wear on wrist, and applies pressure to aforesaid piezoelectric inductor 1;

(c) containing can be to aforementioned airbag inflation and the air pump 3 that loses heart, assembly such as gas bleeder valve 4 and airway 5;

(d) circuit module 6, and it contains central computer, memory body, and be connected in the barometer 7 of airbag airway;

(e) be stated from the operation software 8 of circuit module, its may command airbag air pressure is looked for the suitableeest measuring air pressure, measures radial artery blood pressure wave mode under the suitableeest measuring air pressure, and will be filtered from the electric wave of piezoelectric inductor 1, amplifies, and analyzes;

(f) power supply 91, and

(g) have the instrument host 9 of shell, its element with (c) to (f) contains to be received wherein.

According to the present invention, piezoelectric inductor 1 wherein can be, but be not defined as existing ceramic Lead zirconatetitanate (PZT) piezoelectric patches, or macromolecule polyvinylidene fluoride (PVDF) piezoelectric patches, or stress type (Strain Gauge) piezoelectric element, or semi-conductor type (Semi-Conductor) silicon piezoelectric element etc.; This induction apparatus 1 can be independent of wrist strap or other hardwares, but see through adapter the electric wave signal is reached circuit module 6.When test, earlier this induction apparatus 1 is fixed in the radial artery top (as shown in Figure 2) of wrist with adhesive plaster or elastic webbing (as elastic cord or elastic tape etc.), the wrist strap that will have main frame again puts wrist, and the airbag in the wrist strap is just in time pushed down induction apparatus.When airbag was accepted the air-pump inflating pressurization, airbag was exerted pressure to induction apparatus, and induction apparatus is exerted pressure to radial artery again, and the pulse wave signal that causes induction apparatus to capture strengthens (please refer to Fig. 3-1,3-2,3-3).

One of technology emphasis of the present invention is to utilize air pump progressively airbag pressure to be increased to a level pressure (200mmHg for example by zero, Fig. 3-1), write down the blood pressure pulse wave (Fig. 3-2) that induction apparatus captured at this aeration period, and calculate the main wave height (Primary Peak Height, Fig. 3-3) of each pulse wave.Generally speaking, this main wave height was changed from small to big before this at aeration period, more from large to small, when main wave height presents maximum (generally between 70-150mmHg, Fig. 3-2), airbag pressure at that time is defined as the suitableeest measuring air pressure (Optimal Testing Air Pressure) according to the present invention.The blood pressure wave mode signal of induction apparatus is the strongest under this state, and just signal-noise is higher than (Signal-to-Noise Ratio).When airbag air pressure is lower than this value, because of pressure between piezoelectric inductor and radial artery transmit bad, cause the pulse wave signal a little less than; When airbag air pressure was higher than this value, because of wrist strap, airbag reached induction apparatus radial artery is exerted pressure excessively, lowers arterial flow, also causes the pulse wave signal to weaken and modification.

One of another important step that the present invention implements records the suitableeest measuring air pressure with above-mentioned aeration step earlier at the beginning of measuring radial artery blood pressure wave mode, with near airbag pressurising atmospheric pressure value (or it) so far, just carry out the blood pressure wave mode then and monitor again.Be charged to certain atmospheric pressure value (for example 200mmHg) rapidly if change above-mentioned aeration step into elder generation, progressively airbag pressure reduced again.During losing heart, this, equally can find the suitableeest measuring air pressure according to above-mentioned same principle and step.

Foregoing piezoelectric inductor, its shape and size also do not hinder execution of the present invention.According to the present invention, it is one round that the induction main body of piezoelectric inductor can be, and square is other geometric thin slices, and its thickness can be from scopes such as 0.1mm to 5mm, and its diameter or the length of side can be from scopes such as 1mm to 100mm.The preferable states of piezoelectric inductor is a thin rounded flakes, its diameter is 2～5mm, thickness is 0.1 to 3mm, its electric wave signal reaches circuit module for seeing through two positive negative conductors, its power supply (stress type (Strain Gauge) piezoelectric element or semi-conductor type (Semi-Conductor) silicon piezoelectric element need additional power source, but PZT or PVDF piezoelectric patches do not need power supply) sees through the lead supply by the battery or the external power supply of circuit module.

When test, feel the pulse with finger earlier and find out position of radial artery, again with the piezoelectric inductor side of being fixed thereon.Shown in Figure 4 according to the present invention, another preferable states of piezoelectric inductor 1 is a rectangle thin slice, and its length (along hands body direction) is 1～30mm, and width (along the hands cross direction) is 15～60mm, other bindings or supplied character and above-mentioned being as good as.When test, because the induction apparatus covering scope is enough big, do not need to find out earlier definite position of radial artery, after about fixed-site of wrist radial artery as long as induction apparatus can be tested.

According to of the present invention shown in Figure 5, another preferable states of piezoelectric inductor is for to be built in above-mentioned rectangle thin slice in the wrist strap 2, and the one side of its thin slice contacts with airbag in the wrist strap, and another side then contacts with the outer layer cloth of wrist strap.When test, only need wrist strap 2 and banded instrument host 9 thereof are worn in the wrist top, can test.

According to of the present invention shown in Figure 6, its piezoelectric inductor 1 can be formed a piezoelectricity inductive module by a plurality of (at least two) piezoelectric element 11, and be built in the wrist strap 2, wherein each element is a rectangle (or circular) piezoelectric sheet, and its length of side (or diameter) is 3～5mm, and the substrate of inductive module is a flexible circuit board (soft printed circuit board), combination step is for to form a line a plurality of piezoelectric elements 11 according to the hands cross direction, be fixed on the flexible circuit board, then have in the middle of element and the element slight void (0.1～1mm), to avoid contiguous wave interference.

On circuit module of the present invention, install multiple signals scanning device (Multi-Plexer) and associated drives software additional in addition.Above-mentioned flexible circuit board will reach the multiple signals scanning device with lead or adapter (Connector) from the electric wave signal of each sensing element, and it is connected in signal again and filters and amplifying circuit.When carrying out the blood pressure pulse wave when measuring, the multiple signals scanning device captures the electric wave signal of each piezoelectric element on the induction apparatus module successively, and relatively selects the piezoelectric element of the forceful electric power ripple signal of tool.Compared to other elements, the position of this element must be just in time above the radial artery or near it, and therefore the signal that is obtained is the strongest.

According to the present invention, tool this element of the strongest signal is chosen as measuring element, and the signal of other elements then no longer utilizes, and is then identical with above-mentioned other preferable states as for other measurement step (surveying air pressure etc. as optimal dose).Above-mentioned multiple component number, at least two, and be advisable with three to five, be target with the hands wide region of containing 10～25mm.Compared to above-mentioned other preferable states examples, this piezoelectricity inductive module can press close to the wrist surface during test pressurized, and induction range is big, can be fit to various hand-type sizes because of utilizing flexible circuit board as substrate.

The piezoelectric inductor of aforementioned three preferable states, its advantage are that the pulse wave reconnaissance range enlarges, and can save finger and feel the pulse and look for the step of position, and can adapt to not homochirality size.In addition, general masses can measure voluntarily, must be by trained doctor or nursing staff on behalf of operation.

According to the present invention, wrist strap wherein can be the existing cloth wrist strap that is used for wrist formula electric sphygmomanometer, an airbag is housed in it, the size of airbag then according to general wrist blood pressure measuring regulation (its along the width of hands body direction between 60～90mm, its along the girth of hands cross direction between 80～150mm).The air-locked airbag of this plastic cement (or rubber) has two valves usually, and one of them is connected to the barometer of circuit module, and another is connected to the airway that leads in air pump and gas bleeder valve.When air pump is accepted formula software of the present invention instruction and is begun to inflate, the gas bleeder valve temporary close, airbag air pressure raises, and its value is monitored by barometer; When gas bleeder valve acceptance instruction began to lose heart, gas bleeder valve was opened, and airbag air pressure is decline therefore.In order to wear conveniently, usually install the sheet of a slice U type or ㄈ type in the wrist strap in addition, the openings of sizes of this sheet and the thickness of wrist and width are suitable, be convenient to wrist strap and last main frame thereof are worn on wrist, this sheet contains outstanding cramp in addition, be exposed to the wrist strap cloth outside, the shell that it act as in conjunction with main machine structure of the present invention is fixed in main frame on the wrist strap.In addition, can on airbag, add pocket of system, again the piezoelectricity sensing element is loaded in it, when airbag is inflated, can apply pressure to piezoelectric inductor exactly according to the preferable states explanation of earlier figures 4 of the present invention and Fig. 5; Similarly, the pocket of this piezoelectric inductor also can be fixed in other interior positions of wrist strap, for example between wrist strap cloth and airbag, in order to pressurization.

According to the present invention, air pump wherein is similar to the air air pump that general electric sphygmomanometer uses, and it is accepted dc source promotion blade and rotates and inflate.According to the present invention, gas bleeder valve wherein can be the On-Off electromagnetic valve switch that uses similar in appearance to general electric sphygmomanometer, and it is accepted program control instruction unpack or closes gas check valve; This gas bleeder valve can be analogy (Analog) electromagnetic valve switch again, and its valve is opened size according to the decision of voltage or current value, and this kind analogy valve more can be regulated and control disappointing speed compared with On-Off switch (can only standard-sized sheet or complete shut-down).According to the present invention, the substrate of circuit module wherein can be a printed circuit board (PCB) (Printed Circuit Board), be implanted with central computer (CPU) on it, memory body (for example Flash or RAM etc.), barometer, signal filter element, the signal amplifier element, the buzz device, real clock (Real-Time Clock), and other electronics spare parts etc.For ease of showing test process and result, circuit module can contain a liquid crystal (LCD) or light-emittingdiode (LED) display.In addition, this circuit module also can install a multiple signals scanning device (Multi-Plexer) additional, with the circuit requirements of the preferable states that meets earlier figures 6.

According to the present invention, circuit module wherein is loaded with an operation software, and this software formula can drive relevant hardware (as air pump according to operational flowchart shown in Figure 7, gas bleeder valve, central computer, barometer, liquid crystal display, piezoelectric inductor etc.) and reach following target:

(1) air pressure of control airbag;

(2) seek the suitableeest measuring air pressure;

(3) under the suitableeest measuring air pressure, measure the radial artery wave mode;

(4) will measure the wave mode signal filter and amplify;

(5) will measure the wave mode signal analyze and calculate.

According to the present invention, power supply wherein can be by general aneroid battery (deserted), lithium battery (but recharge use), and Ni-MH battery (but recharge use) or other types battery provide.Power supply required for the present invention again can be provided by general alternating current power supply (as 110V or 220V etc.).If use alternating current power supply, can install one on the circuit module then of the present invention additional and exchange the transformator (Transformer) that changes direct current, to provide the component of only accepting direct current required power supply.

According to the present invention, utilize the accurate measurement technology of aforementioned non-invasion blood pressure pulse wave, can measure physiology mean blood pressure (Physiological Mean Blood Pressure) in the blood pressure according to following steps:

(a) record systolic pressure (SBP) and diastole (DBP) according to existing electric sphygmomanometer concussion technology (Oscillometric Method);

(b) measure an accurate blood pressure wave mode according to the present invention, and with X-Y plane mapping (Fig. 8), wherein Y-axis is relative magnitude of voltage V, X-axis is actual time t;

(c) the relative voltage meansigma methods V (mean) with the blood pressure wave mode in (b) calculates with following formula.

------------(1) of V (mean)=V-t integrated value/(t2-t1)

Wherein V (mean) is the relative voltage meansigma methods, and the V-t integrated value is the V-t mode chart in the integrated value of t1 (wave mode starting point) to the scope of t2 (wave mode end point), and t2-t1 is the time interval of single wave mode, (d) calculates the physiology mean blood pressure according to following formula:

MBP＝V(mean)*(SBP-DBP)/(VS-VD)-------(2)

Wherein PMBP makes a living and pats equal blood pressure, and V (mean) is the relative voltage meansigma methods, and SBP is a systolic pressure, and DBP is a diastolic pressure, and VS is the maximum (crest) of blood pressure wave mode, and VD is the minima (trough) of blood pressure wave mode.

For obtaining the physiology mean blood pressure of more representative and accuracy, one of preferable states of the present invention is the more than one blood pressure wave mode of acquisition, and the physiology mean blood pressure PMBP that calculates each blood pressure wave mode averages these a plurality of PMBP again, complies with following formula:

PMBP(mean)＝SUM(PMBP)/N---------(3)

Wherein PMBP (mean) makes a living and pats the meansigma methods of equal blood pressure PMBP, and SUM (PMBP) is the summation of N PMBP, and N is the number of blood pressure wave mode.Above-mentioned existing electronic blood pressure concussion technology (Oscillometric Method consults US patent4,860,760), the general practice is summarized as follows:

(a) airbag air pressure is boosted to certain value (as 200mmHg) rapidly;

(b) the barometrical blood pressure wave mode of record in progressively slowly losing heart, and calculate wave height (Peak Height) and make wave height-time X-Y figure;

(c) find out on this figure lose heart during the maximum of wave height;

(d) maximum with this wave height is a benchmark, follow X-axis air pressure rising direction and find out 50% o'clock air pressure corresponding to maximum wave height, this be systolic pressure (Systolic Pressure, SBP);

(e) maximum with this wave height is a benchmark, follow X-axis air pressure and reduce direction and find out 70% o'clock air pressure corresponding to maximum wave height, this be diastolic pressure (Diastolic Pressure, DBP);

(f) according to clinical aligning step the systolic pressure and the diastolic blood pressure values that record are proofreaied and correct, to improve accuracy.

Because instrument system of the present invention has the required wrist strap of above-mentioned steps, airbag, barometer, central arithmetical unit, air pump, gas bleeder valve, and the operation software etc., therefore can record systolic pressure and diastolic pressure earlier according to above-mentioned steps, record accurate blood pressure wave mode according to blood pressure wave mode piezoelectric inductor of the present invention again, calculate medically very important physical mean blood pressure according to above-mentioned formula (1) to (3) more at last.

According to the present invention, measure the blood pressure pulse wave with the non-intrusion type fraction, and can measure heart rate variability and autonomic nerve function according to the following step:

(a) the continuous blood pressure wave mode of (as 5 minutes or 24 hours) acquisition testee in the testing period;

(b) one of selecting in the blood pressure wave mode specified point (as main crest summit) is the wave mode reference point;

(c) calculate the time interval (as main crest-main corrugation pitch) of each wave mode reference point and next wave mode reference point;

(d) calculate the meansigma methods and the standard deviation of time interval in the testing period;

(e) convert time interval to frequency spectrum with quick Fu Lier transformation approach (Fast Fourier Transform), and calculate high frequency composition (High Frequency Component, HF, 0.15-0.4Hz), low frequency composition (Low Frequency, LF, 0.04-0.15Hz), extremely low frequency composition (Very Low Frequency, VLF, 0.0-0.04Hz), and total degree of variation (Total Power);

(f) the time interval meansigma methods in (d) is defined as heart beat cycle (Period), its inverse is defined as heart rate (Heart Rate); With the standard deviation (Standard Deviation) of the time interval in (d) be defined as heart rate variability (Heart Rate Variability, HRV); With the heart rate variability in (f) with (e) in total degree of variation (Total Power) be defined as the index of representing the autonomic nerve gross activity; Go out LF% (=LF/ (LF+HF) * 100%) and HF% (=HF/ (LF+HF) * 100%) according to the calculation of parameter in (e), and definition LF% is the index of representative sympathetic activity, HF% is the active index of representative parasympathetic nervous, and other defines LF/HF is the equilibrated index of sympathetic-parasympathetic nervous.More than the analytical method (comprising time range (Time Domain) and frequency range (Frequency Domain)) of every heart rate variability, the definition of its parameter, and with the association of autonomic nerve function, please refer to " Task Force of the European Society of Cardiologyand the North American Society of Pacing and Electrophysiology.Heart ratevariability:standards of measurement; physiological interpretation, andclinical use.Circulation.1996; 93:1043-1065. "

General normal staff radial artery blood pressure wave mode can be divided into 1-wave mode (Fig. 9-1), 2-wave mode (Fig. 9-2), and 3-wave mode (Fig. 9-3).According to the present invention, Fig. 9-1 reaches shown in the table 1 to Fig. 9-3, utilizes the accurate blood pressure wave mode of aforementioned Noninvasive measurement technology, can differentiate the identity of testee again according to the following step:

(a) the continuous blood pressure wave mode of the testee of acquisition one regular (as 50 seconds to 1 minute);

(b) according to Fig. 9-1 to the starting point of finding out each blood pressure wave mode shown in the 9-3 (being trough), terminal point (being the starting point of next wave mode), and each wave crest point and trough point;

(c) according to the crest number of Fig. 9-1 to each blood pressure wave mode of calculating shown in Fig. 9-3, time, pressure, oblique angle, area, and standardization characteristic parameter value (reference table 1) such as (Normalized);

(d) calculate the meansigma methods of these parameter values in test period, and they are defined as this testee blood pressure wave mode feature datum line (Characteristic Baseline);

(e) as if the similarity (Similarity) of the blood pressure wave mode characteristic ginseng value of next undisclosed testee and feature datum line tool certain degree (d), the testee of then judging this testee and aforementioned (a)～(d) is same people, otherwise is different people;

(f) if there is group (for example more than two people) respectively to record earlier blood pressure wave mode feature datum line, in the future if wherein a people is with unidentified acceptance test, then can compare one by one according to the blood pressure wave mode characteristic ginseng value of this testee and indivedual data of this group, and select the similarity soprano, judge that according to this this testee is this known identities person; The similarity of above-mentioned so-called certain degree can be according to experiment and discriminating demand standard in addition.

One of preferable states of the present invention is that all parameter values of blood pressure wave mode feature are treated (equalweighting) on an equal basis, and the similarity of each parameter value is defined as in the positive and negative percentage ratio definite value of feature datum line (as ± 20%), and when having in these parameters when surpassing a predetermined in advance number ratio (as 80%) and satisfying the parameter similarity, then judge total similarity standard that reaches, therefore advance one one and judge two groups of blood pressure wave mode data, otherwise be different people from same people.The above-mentioned parameter similarity, can be decided to be on demand the feature datum line ± 10% or low value more, differentiate rigorous degree to increase identity, or be decided to be ± 30% or higher value, differentiate rigorous degree to reduce identity; Similarly, the number of parameters ratio that satisfies similarity also can fix on 90% or higher value, differentiates rigorous degree to increase, or fixes on 70% or low value more, to reduce rigorous degree.

One of another preferable states of the present invention be with Fig. 9-1 to the parameter shown in the 9-3 crest number (being generally 1.0 to 3.0) and standardization after time of (Normalized), pressure, the oblique angle, and the characteristic parameter value of area is defined as the emphasis parameter that meets similarity, and the time of other not standardized, pressure, the oblique angle, and area parameters then is non-emphasis parameter.When satisfy the parameter similarity (for example between the feature datum line ± 20% in) non-emphasis parameter judge that then two groups of blood pressure wave mode data are from same people when surpassing prior predetermined number ratio (as 80%).When the non-emphasis parameter that satisfies the parameter similarity is lower than prior predetermined number ratio, but the emphasis parameter that satisfies the parameter similarity is then still judged two groups of blood pressure wave mode data from same people, otherwise is different people when surpassing prior predetermined number ratio (as 80%).As previously mentioned, the arteriotony wave mode is (for example nervous because of factors such as emotion and physiology sometimes, palpitating speed when indignation or fever, hypertension) slight variations takes place, but the inventor finds the time of (Normalized) after the standardization, pressure, oblique angle, and the characteristic parameter value of area quite stable and become personalized features then.Compare the characteristic parameter value of (Normalized) after not standardized and the standardization simultaneously, can improve the accuracy of identity authentication.

Above-mentioned standardization (Normalization) step can be abideed by general existing mathematics or statistical normalization step, and its target is not had the parameter value of unit (Dimensionless) for the parameter value that has a physical unit with is converted into.To shown in Fig. 9-3 and the table 1, one of normalization step preferable states of the present invention is with the cycle (Period of each time parameter value divided by the blood pressure wave mode as Fig. 9-1; Be ripple-wave space); Each pressure parameter value is divided by the crest height of wave (referring to 3-3 figure definition) of blood pressure wave mode; The denominator of each oblique angle parameter value is divided by the crest height of wave (referring to Fig. 3-3 definition) of blood pressure wave mode, and its molecule is divided by the cycle (Period of blood pressure wave mode; Be ripple-wave space); Each area parameters value is divided by the gross area of blood pressure wave mode.Because be subjected to influences such as the aging and acute and chronic diseases of human body natural, everyone blood pressure wave mode can progressively change in time, therefore aforementioned blood pressure wave mode feature datum line should regularly measure renewals (for example each year or 2 years), to keep the accuracy of identity authentication.

Table 1 blood pressure wave mode characterisitic parameter value defined

Parameter/parameter-definition	(Fig. 8 a) for the 1-wave mode	2-wave mode (Fig. 8 b)	3-wave mode (Fig. 8 c)
				The crest number	1	2	3
Main wave crest point	B	B	B
				Main trough point	A，C	A，E	A，G
The subwave peak dot	Do not have	D	D，F
				The subwave valley point	Do not have	C	C，E
Time parameter	T1＝ab T2＝ac	T1＝ab T2＝bc T3＝cd T4＝de	T1＝ab T2＝bc T3＝cd T4＝de T5＝ef T6＝fg
				The standardization time parameter	NT1＝ab/ac	NT1＝ab/ae NT2＝bc/ae NT3＝cd/ae NT4＝de/ae	NT1＝ab/ag NT2＝bc/ag NT3＝cd/ag NT4＝de/ag NT5＝ef/ag NT6＝fg/ag
Pressure parameter	P1＝Aa P2＝Bb P3＝Cc	P1＝Aa P2＝Bb P3＝Cc P4＝Dd	P1＝Aa P2＝Bb P3＝Cc P4＝Dd P5＝Ee P6＝Ff
				The standardization pressure parameter	NP1＝Aa/Bb NP2＝Cc/Bb	NP1＝Aa/Bb NP2＝Cc/Bb NP3＝Dd/Bb	NP1＝Aa/Bb NP2＝Cc/Bb NP3＝Dd/Bb NP4＝Ee/Bb NP5＝Ff/Bb
The oblique angle parameter	D1＝(Bb-Aa)/ab D2＝(Bb-Cc)/bc D3＝D1+D2	D1＝(Bb-Aa)/ab D2＝(Bb-Cc)/bc D3＝(Dd-Cc)/cd D4＝(Dd-Ee)/de D5＝D1+D2 D6＝D3+D4	D1＝(Bb-Aa)/ab D2＝(Bb-Cc)/bc D3＝(Cc-Dd)/cd D4＝(Dd-Ee)/de D5＝(Ff-Ee)/ef D6＝(Ff-Aa)/fg D7＝D1+D2 D8＝D3+D4 D9＝D5+D6
				Standardization oblique angle parameter	ND1＝ ((Bb-Aa)/Bb)/(ab/ac) ND2＝ ((Bb-Cc)/Bb)/(bc/ac) ND3＝ND1+ND2	ND1＝ ((Bb-Aa)/Bb)/(ab/ae) ND2＝ ((Bb-Cc)/Bb)/(bc/ae) ND3＝ ((Dd-Cc)/Bb)/(cd/ae) ND4＝ ((Dd-Ee)/Bb)/(de/ae) ND5＝ND1+ND2 ND6＝ND3+ND4	ND1＝ ((Bb-Aa)/Bb)/(ab/ag) ND2＝ ((Bb-Cc)/Bb)/(bc/ag) ND3＝ ((Cc-Dd)/Bb)/(cd/ag) ND4＝ ((Dd-Ee)/Bb)/(de/ag) ND5＝ ((Ff-Ee)/Bb)/(ef/ag) ND6＝ ((Ff-Aa)/Bb)/(fg/ag) ND7＝ND1+ND2 ND8＝ND3+ND4 ND9＝ND5+ND6

Area parameters	A1＝AabB A2＝BbcC A3＝A1+A2	A1＝AabB A2＝BbcC A3＝CcdD A4＝DdeF A5＝A1+A2 A6＝A3+A4 A7＝A5+A6	A1＝AabB A2＝BbcC A3＝CcdD A4＝DdeE A5＝EefF A6＝FfgG A7＝A1+A2 A8＝A3+A4 A9＝A5+A6 A10＝A7+A8+A9
				The standardization area parameters	NA1＝A1/A3 NA2＝A2/A3	NA1＝A1/A7 NA2＝A2/A7 NA3＝A3/A7 NA4＝A4/A7 NA5＝A5/A7 NA6＝A6/A7	NA1＝A1/A10 NA2＝A2/A10 NA3＝A3/A10 NA4＝A4/A10 NA5＝A5/A10 NA6＝A6/A10 NA7＝NA1+NA2 NA8＝NA3+NA4 NA9＝NA5+NA6

Annotate: (1) small letter a, b, c, d, e, f, g etc. are time point, unit is second.

(2) capitalization A, B, C, D, E, F, G etc. are the point on the blood pressure wiggle trace, coordinate unit is (pressure, second) or (voltage, second).

(3) area parameters (as AabB) is the integral area (also can simplify and be defined as the trapezoidal area that 4 corner points form) that 4 corner points and curve form.

According to the present invention, Figure 10, Figure 11, and shown in Figure 12, utilize the accurate blood pressure wave mode of aforementioned non-intrusion type measurement technology, can measure according to the following step and breathe wave mode and frequency:

(a) (as 1～10 minute) captures the blood pressure wave mode of testee and makes X-Y figure that (Figure 10 a), wherein the X value is the time, and the Y value is voltage or pressure continuously in the testing period;

(b) the X value (being time value) of finding out the main wave crest point of each wave mode and Y value (being voltage or force value) (referring to Figure 10 b);

(c) data with the main wave crest point of (b) makes continuous XY figure (Figure 11), is the breathing wave mode of this testee;

(d) the wave mode number (as eight) in every regularly (as a minute) in (c) is calculated, be respiratory frequency or Respiration Rate (as each minute eight breathings).

Be with the basis of main crest in above-mentioned (b) step as all computational analysiss, if change with main trough (is the starting point of each wave mode, also be minimum point) or the specified point of other blood pressure wave modes as basic point, equally also can obtain to breathe wave mode and frequency (or Respiration Rate) according to above-mentioned steps.

In addition, according to Figure 10 b and shown in Figure 12, if the time interval (with reference to figure 10b) of the main crest-main crest of testee is calculated, and with its inverse (being the moment heart rate) as the Y value, in addition the corresponding time is treated as the X value, and make continuous X-Y figure, then this X-Y figure (Figure 12) is the breathing wave mode of testee.Similarly, the wave mode number (as 8) in every regularly (as a minute) in this breathing mode chart is calculated, be respiratory frequency or Respiration Rate (as each minute eight breathings).

Shown in Figure 13 according to the present invention, utilize the accurate blood pressure wave mode of aforementioned non-intrusion type measurement technology, can monitor the symptom of cough or sneeze according to the following step:

(a) capture the blood pressure wave mode of testee continuously;

(b) calculate testee three parameter values (time interval of promptly main crest-main crest of the blood pressure wave mode of interior (as a minute) in the early stage, the force value of main crest value, and the force value of main trough) meansigma methods and standard deviation, and with the meansigma methods definition datum line of three parameter values for this reason;

(c) monitor three parameter values of blood pressure wave mode at any time at test period, if one of them departs from (containing above) more than the prior prearranged multiple (for example three times) of its datum line accurate deviation up to standard, then this wave mode is called suspicious irregular material point;

(d) if the generation tool certain frequency of this suspicious irregular material point (taking place once during for example per four wave modes) then gives in ignorance;

(e), then define this material point and be cough or sneeze point if (do not have certain frequency) takes place this suspicious irregular material point at random;

(f), then can obtain cough or sneeze frequency (as per minute three times) with the regular statistics of the cough of (e) or sneeze point.

Above-mentioned predetermined in advance standard deviation multiple can be verified by human experimentation.For example, light more shallow cough, the degree of its blood pressure wave mode deviation average is lower, and therefore predetermined in advance standard deviation multiple can be decided to be 3 to 4, and heavier darker cough or sneeze then can be decided to be 4 to 6.The suspicious irregular material point of aforementioned again tool certain frequency often is because bradytachycardia (Cardiac Arrhythmias) causes, and therefore should foreclose.

The present invention further provides a kind of novel physiological signal monitoring instrument system (as shown in figure 14) that hospital isolates sufferer that is used for, it comprises:

(a) aforementioned non-intrusion type of the present invention accurate blood pressure wave mode measurement technology and instrument system thereof;

(b) existing body temperature measurement technology, and temperature inductor is placed on the wrist strap of (a);

(c) have the wireless signal transmission technology now, and one group of wireless transmission transmitting-receiving module is placed in the main frame of (a), another group places to be responsible in the ward receiving in the bedside analyzer of sufferer physiological signal;

(d) measure the heart beating of isolating sufferer with the instrument system of aforementioned (a), blood pressure (systolic pressure, diastolic pressure, physiology mean blood pressure) is breathed wave mode and frequency, and judges whether had palpitation of sufferer, rapid breathing, cough or sneeze;

(e) measure the wrist body temperature of sufferer with the temperature inductor of aforementioned (b), and judge whether sufferer has a fever;

(f) (d) and (e) physiological signal are sent to the bedside analyzer of (c) by the main frame of (a) with the wireless transmission module of (c);

(g) the bedside analyzer again sufferer physiological signal and analysis result thereof are seen through regional networking (Local AreaNetwork, LAN) or the Internet (Internet) spread out of the ward.

Above-mentioned existing body temperature measurement technology can use a low profile thermal galvanic couple, a resistance-type electronic component, or an infrared ray electric device.The three is all thermal sensible element, body temperature can be converted to voltage or current signal.Reach the required time of hygral equilibrium in order to improve body temperature accuracy of measurement and minimizing, behind the aforementioned hot sensing unit, can on wrist strap, increase by a small pieces metal, this sheet metal outer surface be exposed to the wrist strap cloth outside, directly contact with wrist skin when wearing, and responsible heat conduction.This sheet metal links to each other in wrist strap with thermal sensible element in addition, and thermal sensible element links to each other with circuit module of the present invention again, so forms a complete body temperature measurement system.Above-mentioned Radio Transmission Technology, can use RF (Radio Frequency) wireless module of general commercialization, its frequency range can be at ISM Band (i.e. [industry, science, medical treatment] band sharing) commonly used, wherein the most frequently used communications protocol is blue bud (Blue Tooth, 2.4GHz) (contain IEEE 802.11b, 802.11a reaches 802.11g to Wi-Fi, 2.4～5.6GHz), and low frequency ISM (433～915MHz).In addition, U.S. food drug control office (FDA) also stipulates the WMTS channel (608～1429MHz) of a medical device special use.Usually the RF wireless module is operated in a pair of two-way mutual biography mode.

With the above-mentioned example that is applied as of the present invention, one of them wireless receiving and dispatching die set is in wrist formula main frame of the present invention, and another then is placed on the interior bedside analyzer of isolation ward.Above-mentioned bedside analyzer can be a desktop or carry-along computer, or other tool computings, stores, show, and the instrument system of transfer function, and wireless receiving and dispatching module and bedside analyzer can see through the standard interface (as RS-232 (COM Port), USB, IEEE 1394 etc.) link.The heart beating of aforementioned sufferer is then judged this sufferer had palpitation phenomenon if surpass the normal cardiac rate (the highest 100 times as per minute) of general medicine definition; The existing explanation of the judgement of aforementioned cough or sneeze no longer repeats.Respiratory frequency upper limit of definable (as per minute 20 times) in addition goes up and prescribes a time limit when the respiratory frequency of testee surpasses this, promptly is judged to be rapid breathing;

In addition, can when sufferer body temperature surpasses 38 degree C, promptly be judged to be fever in addition according to the general medicine standard.After the physiological signal of sufferer is passed on the bedside analyzer, can be thereon through storing, analyze, and after showing, see through again local-area network in the hospital (Local Area Network, LAN) or the Internet (Internet) spread out of ward (for example reaching colonization station or hospital's sufferer data servomechanism etc.).

The present invention further provides a kind of instrument system (shown in the 15th figure) that is used to monitor the house quarantine common people, it comprises:

(a) aforementioned non-intrusion type of the present invention accurate blood pressure wave mode measurement technology and system instrument system thereof;

(b) measure the house quarantine common people's heart beating with the instrument system of (a), blood pressure (systolic pressure, diastolic pressure, mean pressure), the blood pressure wave mode is breathed physiological signals such as wave mode and frequency, and judges whether had palpitation of these common people in view of the above, violent blood pressure, rapid breathing, cough or sneeze;

(c) measure these common people's body temperature with existing body temperature measurement technology, and judged whether the fever symptom in view of the above;

(d) with existing Radio Transmission Technology the physiology information of (a)～(c) is regularly reached the signal receiving and analyzing device of putting in family;

(e) signal receiving and analyzing device stores the physiology information, and analysis regularly reaches health office (as health bureau, Department of Health, hospital etc.) with the Internet (Internet) transmission or phone data machine (Modem) after (or demonstration);

(f) health office regularly collects, and arrangement, and not morbidity of statistics are fallen ill, and restorative isolation common people number.

For preventing to go out in violation of rules and regulations, health office can utilize the Internet or phone data machine to assign test instruction more any time and give the bedside analyzer, and the bedside analyzer will instruct the wrist formula physiological monitor main frame of reception and registration with wireless transmission method again.If these lattice are at this moment from the common people, behind the notice sound of hearing bedside analyzer or wrist formula physiological monitor main frame (seeing through its buzz device that contains), just should wear wrist formula physiological monitor main frame, test.If this isolations common people go out in violation of rules and regulations, health office assign take a sample test the instruction back regular in (in) as ten minutes do not receive physiological signal, should judge according to this that these common people go out in violation of rules and regulations, and further carry out measure of control.If this isolation common people go out in violation of rules and regulations, but by other people at home on behalf of test, then health office can judge not to be same people's data according to this, and take necessary measure of control by identity authentication technique provided by the invention.Above-mentioned signal receiving and analyzing device can be a desktop or laptop computer, or carry-on numerical digit assistor (PDA), or has transmission, stores, analyze, and other instruments of Presentation Function.Above-mentioned not morbidity is fallen ill, and restorative definition, can be by health competent authority according to blood pressure, and respiratory frequency, cough and sneeze, the standard that reaches above-mentioned physiological parameters such as body temperature is controlled.Relevant again body temperature, blood pressure, technology such as wireless transmission and networking transmission, the front is existing to be elaborated, and repeats no more.

Stating and implementing aspect only is to be used for illustration the present invention, and non-limiting the present invention.

Example 1: non-intrusion type wrist radial artery blood pressure wave mode measuring instrument system

This instrument system example constitutes (as shown in figure 16, each element is according to label) by following spare part:

(a) piezoelectric inductor 1a who is made up of stressor (Strain Gauge), its main body size is 5mm thin rounded flakes (3mm is thick), includes signal and filters, and amplifies, and proofreaies and correct circuit such as temperature-compensating.Except that circular inductor body, other has the circuit module of a wire bond to wrist formula physiological monitor main frame (to be described).Acting as of this lead provides the piezoelectric inductor power supply and transmits the piezoelectricity signal to circuit module.

(b) wrist formula physiological monitor main frame 2a, it contains inflates air pump, gas bleeder valve, standard 2A aneroid battery (two), the RS232 Port, barometer, and contain central processing unit, memory body, and signal is handled the circuit module of (filter, amplify, proofread and correct).This main frame contains the shell of loam cake and lower cover in addition, and this shell contains cramp and osculum, and it can be fixed on the wrist wrist strap (waiting to state), and loam cake also has the button that can operate this instrument.

(c) wrist strap 3a, it contains an airbag and a U shape glue thin slice, and this plastic slice tool cramp and aperture can combine with the lower cover of wrist formula main frame.The general wrist girth of the length of this wrist strap is also long, therefore around one week of wrist the back residue length can opisthotonos, decide with devil's cementation.

The operating procedure of this instrument system is described below:

(d) feel the pulse in the wrist of a healthy aspiration testee (right-hand man all can) with finger, and the definite position that records radial artery.

(e) with the circular piezoelectric inductor body of (a) with immobilization with adhesive tape in the radial artery top.

(f) the wrist formula main frame of (b) is worn wrist in testee with the wrist strap of (c).

(g) by the instrument host of (b) " beginning " key, start test, control software this moment and assign instruction, begin to inflate (this moment, gas bleeder valve cut out) to inflating air pump, when airbag is pressurized to 200mmHg (air pressure evaluation), controls software and assign instruction and carry out slowly losing heart to gas bleeder valve.In this simultaneously, control software and circuit module read and stored barometrical force value and piezoelectric inductor with the speed of per second 500 material points pulse wave signal, control software and calculate to lose heart during (200 reduce to 30mmHg, the wave height of each pulse wave about 20 seconds) (being crest-trough), and the atmospheric pressure value when the decision maximum wave height takes place, this atmospheric pressure value (93mmHg) is the suitableeest measuring air pressure.

(h) control software and assign instruction again to inflating air pump, airbag air pressure is risen to the suitableeest measuring air pressure (93mmHg) from 30mmHg, after control software and circuit module read piezoelectric inductor equally with per second 500 material point speed pulse wave signal, took a sample altogether 5 seconds, and this data and corresponding time value (taking from Real-Time Clock) are stored in the memory body of circuit module.

(i) PC of breakdown, and be connected to the RS-232 Port of wrist formula main frame with its RS-232 (COM Port) connecting line.The operation software of PC is assigned circuit module and the operation software thereof that wrist formula main frame is given in instruction, begins to carry out data and downloads (Data Download).

(j) PC is controlled formula and will be downloaded data and map in the X-Y mode, and wherein X-axis is time (unit for second), and Y-axis is the pressure value (unit is mmHg) of piezoelectric inductor, and its result as shown in figure 17.

Example 2: non-intrusion type wrist radial artery blood pressure wave mode instrument system is used for the application that the physiology mean blood pressure measures

The instrument software and hardware of this example, operating portion is rapid, and all similar example 1 of healthy aspiration testee, but piezoelectric inductor changes a thick piezoelectric element of long wide (wide along the hands) * 2-mm of (along pushing direction) * 20-mm of 5-mm that is made by ceramic PZT into by the 5-mm circular body of example 1; In addition, wrist formula main frame increases a LCD display in addition.Maximum wave height (the current air pressure value is 93mmHg) during obtaining to lose heart according to the operating procedure of example 1, promptly after the step of example 1 (g), continue the operation following steps again:

(a) wrist formula main frame controls that to analyze software be benchmark with the maximum wave height origination point, look for 50% the blood pressure wave mode that wave height is maximum wave height just against pressure release direction (promptly toward pressure rises direction), the atmospheric pressure value (138mmHg) when this blood pressure wave mode takes place is systolic pressure; Control and analyze software and look for 70% the blood pressure wave mode that wave height is maximum wave height just along the direction (being the air pressure descent direction) of losing heart in addition, the atmospheric pressure value (83mmHg) when this blood pressure wave mode takes place is diastolic pressure.

(b) learn that according to relevant human experimentation systolic pressure (a) needs downward revision 25mmHg in addition, diastolic pressure needs downward revision 10mmHg, just can become correct systolic pressure (113mmHg) and diastolic pressure (73mmHg).

(c) according to " detailed description of the present invention " and in formula (1)～(3), calculate this example and test in 5 seconds " the physiology mean blood pressure " meansigma methods (86mmHg).

(d) wrist formula main frame is shown in LCD display with the meansigma methods (86mmHg) of physiology mean blood pressure.

Learn according to relevant human experimentation in addition that (e) this health aspiration testee is with the measured systolic pressure of the manual arteries and veins of intrusive mood intubate, diastolic pressure reaches the physiology mean blood pressure and is respectively 110,68, and 85mmHg.Manual arteries and veins method of testing of display standard intrusive mood intubate and the measured systolic pressure of non-intrusion type radial artery blood pressure wave mode technology of the present invention as a result, diastolic pressure, and physiology mean blood pressure tool high similarity.

Example 3: non-intrusion type wrist radial artery blood pressure wave mode instrument system is used for the application of heart rate variability and the measurement of autonomic nerve function

The instrument hardware and the example 2 of this example are similar, participate in but have two healthy aspiration testees.In addition, piezoelectric inductor changes macromolecule PVDF material into by the PZT piezoelectric of example 2, and its shape is big or small, and (along the hands cross direction) * 0.5mm is thick for long (along pushing the direction) * 20-mm of 5-mm is wide.In addition, this piezoelectric inductor is installed in the wrist strap in advance, outside airbag top and wrist strap between the cloth, its tail end adapter (Tail Connector, constitute by flexible circuit board) the inner and little opening via wrist strap, wrist formula host housing lower cover is linked to the circuit module in the main frame at last.The signal processing circuit of circuit module and LCD display and example 2 are as good as, when wearing, as long as wrist formula main frame is fixed in wrist with wrist strap.After obtaining continous way blood pressure wave mode according to the step of example 1 during operation, carry out following steps again:

(a) capture the blood pressure wave mode of testee continuously, totally 5 minutes.Crest-crest time interval that software calculates each blood pressure wave mode in the test period is analyzed in controlling of wrist formula main frame.

(b) according to document " Task Force of the European Society of Cardiology and the NorthAmerican Society of Pacing and Electrophysiology.Heart rate variability:standards of measurement; physiological interpretation, and clinical use.Circulation.1996; 93:1043-1065. " described method is calculated the heart rate variability parameter of the time range (Time Domain) of testee, i.e. heart beat cycle, heart rate, heart rate variability (HRV).

(c) comply with the heart rate variability parameter that above-mentioned document calculates the frequency range (Frequency Domain) of testee, promptly total degree of variation (Total Power), high frequency composition (HF), low frequency composition (LF), and low frequency composition/high frequency composition ratio.

(d) according to above-mentioned document the heart rate variability of time range and total degree of variation of frequency range are defined as the autonomic nerve activity index; High frequency composition (HF) and high frequency composition percentage ratio (HF/ (CHF+LF)) * 100% with frequency range) be defined as the parasympathetic nervous activity index; Low frequency composition (LF) and low frequency composition percentage ratio (LF/ (HF+LF)) * 100% with frequency range) be defined as the sympathetic activity index; Low frequency composition/high frequency composition ratio (LF/HF) is defined as sympathetic/parasympathetic nervous balance index.

(e) in addition, testee is in above-mentioned blood pressure wave mode test, (connection method is the three-electrode method of standard also to accept the test of 5 minutes standard cardioelectric figure machines (ECG), Lead I, II, and III, and serve as to calculate the source with the data of Lead II), and according to each heart rate variability parameter of above-mentioned document computation time and frequency range.

(f) test result such as table 2.(code name A, heart rate variability that the electrocardiograph of display standard as a result (ECG) method of testing B) and non-intrusion type radial artery blood pressure wave mode technology of the present invention are measured and autonomic nerve activity index are had high similarity as a result for two healthy aspiration testees.

Table 2 heart rate variability and autonomic nerve activity index test result

The testee code name	A		B
					Method of testing	ECG	The present invention	ECG	The present invention
The test posture	Face upward and lie		Face upward and lie
					Heart beat cycle (s)	0.910	0.907	0.723	0.723
Heart rate (inferior/min)	66	66	83	83
					Heart rate variability (HRV) (ms); It is standard deviation	45.1	46.0	57.1	55.4
Total degree of variation (Total Power) (ms*ms)	2037	2120	3265	3073

LF(ms*ms)	420	426	413	418
					LF％	63	61	32	31
HF(ms*ms)	252	275	894	943
					HF％	38	39	68	69
LF/HF	1.67	1.55	0.46	0.44

Example 4: be used for the testee identity identification

The instrument hardware and the example 2 of this example are similar, but piezoelectric inductor changes by following element and constitutes:

(a) flexible circuit version, as the substrate and the basic circuit of piezoelectric inductor, (along the hands cross direction) * 0.5mm is thick for long (along pushing the direction) * 20mm of 6mm is wide for its main body size; Its tail end adapter size is 6mm * 50mm * 0.5mm in addition.

(b) three ceramic PZT piezoelectric elements, wherein the size of each element is 4mm (length) * 4mm (wide) * 1mm (thick), and is arranged on the flexible circuit version along the hands cross direction, has between element and the element between the 1-mm apart from (can with reference to the 5th figure).

This piezoelectric inductor is installed in the wrist strap in advance, and its step and example 3 are similar, in addition, circuit module is handled outside (promptly filter, amplify, and proofread and correct) circuit except signal, other increases a multiple signals scanning device (Multi-Plexer), place signal processing circuit before.When testing, the software driving multiple signals scanning device of controlling of wrist formula main frame captures the electric wave signal of each element on the piezoelectric inductor successively, and calculates the wave height (being crest-trough) of the blood pressure wave mode of these three elements.Control software and further select the source of the piezoelectric element of tool maximum wave height as the blood pressure waveform data, other two elements then no longer utilize.After control software and look for the suitableeest measuring air pressure step, shown in example 1, under the suitableeest measuring air pressure, carry out the continuous blood pressure wave mode test in ten seconds.Testee A, B, each accepts test (Figure 17,18-1,18-2,19) for the first time to reach C, and one of three testees are with unidentified acceptance again test (Figure 20) for the second time every other day; The blood pressure wave mode and the parameter value thereof of test result are listed in Figure 17-20 and table 3.By Figure 18-1,18-2,20 and table 3 can find that the blood pressure wave mode characteristic parameter value of three testees all has nothing in common with each other.Advance a part again and analyse, this unidentified testee tool 2-ripple blood pressure wave mode, obviously the 3-ripple blood pressure wave mode with testee C very different (with reference to Figure 19,20 and table 3).If all 41 characteristic ginseng values of 2-ripple blood pressure wave mode (are comprised the crest number, time, pressure, the oblique angle, area, and standardization (Normalized) characteristic parameter value) treats (equal weighting) on an equal basis, and with the similarity of each parameter value be defined as between the feature datum line ± 20% in, then this unidentified testee has 38 parameter values (93%) and testee A and satisfies similarity, and have only 25 parameter values (61%) and testee B to satisfy similarity, judge further that therefore this unidentified testee should be testee A (its result and experimental design coincide).

Table 3 testee blood pressure wave mode characteristic parameter value

Testee/parameter	A	B	C	Not clear status
					The crest number	2	2	3	2

Main wave crest point	B	B	B	B
					Main trough point	A，E	A，E	A，G	A，E
The subwave peak dot	D	D	D，F	D
					The subwave valley point	C	C	C，E	C
Time parameter (sec)	T1＝0.155 T2＝0.195 T3＝0.055 T4＝0.345	T1＝0.095 T2＝0.230 T3＝0.060 T4＝0.360	T1＝0.090 T2＝0.100 T3＝0.045 T4＝0.100 T5＝0.085 T6＝0.590	T1＝0.160 T2＝0.165 T3＝0.055 T4＝0.385
					The standardization time parameter	NT1＝0.21 NT2＝0.26 NT3＝0.07 NT4＝0.46	NT1＝0.15 NT2＝0.35 NT3＝0.09 NT4＝0.55	NT1＝0.09 NT2＝0.10 NT3＝0.04 NT4＝0.10 NT5＝0.08 NT6＝0.58	NT1＝0.21 NT2＝0.22 NT3＝0.07 NT4＝0.50
Pressure parameter (mV)	P1＝34.1 P2＝37.3 P3＝35.1 P4＝35.2	P1＝37.5 P2＝40.4 P3＝38.7 P4＝38.8	P1＝25.7 P2＝29.6 P3＝28.4 P4＝28.5 P5＝27.3 P6＝27.8	P1＝34.2 P2＝37.4 P3＝35.2 P4＝35.3
					The standardization pressure parameter	NP1＝0.914 NP2＝0.941 NP3＝0.944	NP1＝0.928 NP2＝0.958 NP3＝0.960	NP1＝0.869 NP2＝0.959 NP3＝0.963 NP4＝0.938 NP5＝0.940	NP1＝0.914 NP2＝0.942 NP3＝0.945
The oblique angle parameter	D1＝20.65 D2＝11.28 D3＝1.82 D4＝3.19 D5＝31.93 D6＝5.01	D1＝30.10 D2＝7.39 D3＝1.67 D4＝3.89 D5＝37.49 D6＝5.56	D1＝43.00 D2＝12.00 D3＝2.44 D4＝7.50 D5＝0.82 D6＝3.68 D7＝55.00 D8＝9.94 D9＝4.50	D1＝20.06 D2＝13.09 D3＝2.00 D4＝2.65 D5＝33.15 D6＝4.65

Standardization oblique angle parameter	ND1＝0.415 ND2＝0.227 ND3＝0.037 ND4＝0.064 ND5＝0.642 ND6＝0.101	ND1＝0.484 ND2＝0.119 ND3＝0.027 ND4＝0.063 ND5＝0.603 ND6＝0.090	ND1＝1.469 ND2＝0.410 ND3＝0.083 ND4＝0.256 ND5＝0.028 ND6＝0.126 ND7＝1.879 ND8＝0.339 ND9＝0.154	ND1＝0.411 ND2＝0.268 ND3＝0.040 ND4＝0.054 ND5＝0.679 ND6＝0.094
					Area parameters	A1＝5.53 A2＝7.06 A3＝1.10 A4＝11.95 A5＝12.59 A6＝13.05 A7＝25.64	A1＝3.70 A2＝9.10 A3＝1.162 A4＝13.72 A5＝12.80 A6＝14.88 A7＝27.68	A1＝2.49 A2＝2.90 A3＝1.28 A4＝2.81 A5＝2.36 A6＝15.76 A7＝5.39 A8＝4.09 A9＝18.12 A10＝27.60	A1＝5.72 A2＝5.99 A3＝1.94 A4＝13.40 A5＝11.71 A6＝15.34 A7＝27.05
The standardization area parameters	NA1＝0.216 NA2＝0.275 NA3＝0.043 NA4＝0.466 NA5＝0.491 NA6＝0.509	NA1＝0.134 NA2＝0.329 NA3＝0.042 NA4＝0.496 NA5＝0.462 NA6＝0.538	NA1＝0.090 NA2＝0.105 NA3＝0.046 NA4＝0.102 NA5＝0.086 NA6＝0.571 NA7＝0.195 NA8＝0.148 NA9＝0.657	NA1＝0.211 NA2＝0.221 NA3＝0.072 NA4＝0.495 NA5＝0.433 NA6＝0.567

Annotate: (1) small letter a, b, c, d, e, f, g etc. are time point, unit is second.

(2) capitalization A, B, C, D, E, F, G etc. are the point on the blood pressure wiggle trace, coordinate unit is (mV, second).

(3) area parameters (as AabB) is simplified the trapezoidal area that is defined as the formation of 4 corner points.

It should be noted that at last: above embodiment only in order to the explanation the present invention and and unrestricted technical scheme described in the invention; Therefore, although this description has been described in detail the present invention with reference to each above-mentioned embodiment,, those of ordinary skill in the art should be appreciated that still and can make amendment or be equal to replacement the present invention; And all do not break away from the technical scheme and the improvement thereof of the spirit and scope of the present invention, and it all should be encompassed in the claim scope of the present invention.

Claims (26)

1, a kind of non penetration type system for measuring radial artery blood pressure wave is characterized in that: comprising:

One in order to measure the wrist radial artery, and the piezoelectric inductor of the electric wave of blood pressure pulse wave is represented in its energy continuous record and generation;

One its contain airbag, can wear on human body wrist, and the wrist strap that aforesaid piezoelectric inductor is exerted pressure;

One can be to the air pump of aforesaid airbag inflation;

One is connected with in the gas bleeder valve of one of airbag end;

One is connected to the airway of airbag;

One includes central computer, and memory body is provided with the circuit module of operating software in it;

One is connected in the barometer of the airway of airbag;

One power supply, and one can contain the instrument host of receiving wherein with aforementioned portion of element.

2, non penetration type system for measuring radial artery blood pressure wave according to claim 1, it is characterized in that described piezoelectric inductor can be ceramic Lead zirconate titanate (PZT) piezoelectric patches, or macromolecule polyvinylidene fluoride (PVDF) piezoelectric patches, or stress type (Strain Gauge) piezoelectric element, or semi-conductor type (Semi-Conductor) silicon piezoelectric element.

3, non penetration type system for measuring radial artery blood pressure wave according to claim 1, it is one round that the induction main body that it is characterized in that described piezoelectric inductor can be, square is other geometric thin slices, its thickness can be from scopes such as 0.1mm to 5mm, and its diameter or the length of side can be from scopes such as 1mm to 100mm.

4, non penetration type system for measuring radial artery blood pressure wave according to claim 1, it is characterized in that described piezoelectric inductor, be the elongated thin slice, and be to place wrist strap, the one side of its thin slice contacts with airbag in the wrist strap, and another side then contacts with the outer layer cloth of wrist strap, when test, only need wrist strap and banded instrument host thereof are worn in the wrist top, can test.

5, non penetration type system for measuring radial artery blood pressure wave according to claim 1, it is characterized in that described piezoelectric inductor can form a piezoelectricity inductive module by a plurality of (at least two) piezoelectric element, and be built in the wrist strap, wherein each element is a rectangle (or circular) piezoelectric sheet, and its length of side (or diameter) is 3～5mm, and the substrate of inductive module is a flexible circuit board (soft printed circuit board), combination step is for to form a line a plurality of piezoelectric elements according to the hands cross direction, be fixed on the flexible circuit board, then have one in the middle of element and the element to avoid the slight void (0.1～1mm) of contiguous wave interference.

6, non penetration type system for measuring radial artery blood pressure wave according to claim 1, it is characterized in that described circuit module, install the multiple signals scanning device (Multi-Plexer) and the associated drives software that are connected to filtration and amplifying circuit again from the electric wave signal of each sensing element to receive additional.

7, non penetration type system for measuring radial artery blood pressure wave according to claim 1 is characterized in that recording the suitableeest measuring air pressure with aeration step earlier when it is implemented, and with near airbag pressurising atmospheric pressure value (or it) so far, just carries out the blood pressure wave mode then and monitors again.

8, non penetration type system for measuring radial artery blood pressure wave according to claim 7, it is characterized in that the suitableeest wherein said measuring air pressure refers to main wave height (Primary Peak Height) the maximum gas pressure value of blood pressure pulse wave, at this atmospheric pressure value, the blood pressure wave mode signal of induction apparatus is the strongest, and signal-noise is higher than (Signal-to-Noise Ratio).

9, non penetration type system for measuring radial artery blood pressure wave according to claim 1, it is characterized in that described wrist strap can be airbag of installing in the cloth wrist strap, the size of airbag then according to general wrist blood pressure measuring regulation (its along the width of hands body direction between 60～90mm, its along the girth of hands cross direction between 80～150mm).

10, non penetration type system for measuring radial artery blood pressure wave according to claim 9 is characterized in that adding pocket of system on airbag, the piezoelectricity sensing element is loaded in it again, when airbag is inflated, can apply pressure to piezoelectric inductor exactly.

11, non penetration type system for measuring radial artery blood pressure wave according to claim 1 is characterized in that described gas bleeder valve is analogy (Analog) electromagnetic valve switch, and its valve is opened size according to voltage or current value decision.

12, non penetration type system for measuring radial artery blood pressure wave according to claim 1, it is characterized in that described circuit module, its substrate is a printed circuit board (PCB) (Printed Circuit Board), is implanted with central computer (CPU) on it, memory body (for example Flash or RAM etc.), barometer, the signal filter element, signal amplifier element, buzz device, real clock (Real-Time Clock), and other electronics spare parts etc.

13, non penetration type system for measuring radial artery blood pressure wave according to claim 12, it is characterized in that described circuit module contains a liquid crystal (LCD) or light-emittingdiode (LED) display, can install a multiple signals scanning device (Multi-Plexer) additional.

14, non penetration type system for measuring radial artery blood pressure wave according to claim 1 is characterized in that described circuit module is loaded with an operation software.

15, non penetration type system for measuring radial artery blood pressure wave according to claim 13 is characterized in that described software formula, and its operating process comprises:

The air pressure of control airbag;

Seek the suitableeest measuring air pressure;

Under the suitableeest measuring air pressure, measure the radial artery wave mode;

With measure the wave mode signal filter and amplify;

With measure the wave mode signal analyze and calculate.

16, non penetration type system for measuring radial artery blood pressure wave according to claim 1, it is characterized in that described power supply can be by general aneroid battery (deserted), lithium battery (but recharge use), Ni-MH battery (but recharge use) or other types battery provide.

17, non penetration type system for measuring radial artery blood pressure wave according to claim 1, it is characterized in that described power supply can be provided by general alternating current power supply (as 110V or 220V etc.), if use alternating current power supply, then can install one on the circuit module additional and exchange the transformator (Transformer) that changes direct current, to provide the component of only accepting direct current required power supply.

18, a kind of application of non penetration type system for measuring radial artery blood pressure wave is characterized in that: it measures the use step of the physiology mean blood pressure (Physiological Mean Blood Pressure) in the blood pressure:

Record systolic pressure (SBP) and diastolic pressure (DBP) with electric sphygmomanometer concussion technology (Oscillometric Method);

Measure the blood pressure wave mode, and with X-Y plane mapping (Fig. 7), wherein Y-axis is relative magnitude of voltage V, X-axis is actual time t;

The relative voltage meansigma methods V (mean) of the above-mentioned blood pressure wave mode that records is calculated with following formula:

-----------(1) of V (mean)=V-t integrated value/(t2-t1)

Wherein V (mean) is the relative voltage meansigma methods, and the V-t integrated value is the V-t mode chart in the integrated value of t1 (wave mode starting point) to the scope of t2 (wave mode end point), and t2-t1 is the time interval of single wave mode, calculates the physiology mean blood pressure according to following formula:

PMBP＝V(mean)*(SBP-DBP)/(VS-VD)-------(2)

Wherein PMBP makes a living and pats equal blood pressure, and V (mean) is the relative voltage meansigma methods, and SBP is a systolic pressure, and DBP is a diastolic pressure, and VS is the maximum (crest) of blood pressure wave mode, and VD is the minima (trough) of blood pressure wave mode;

Physiology mean blood pressure PMBP according to following formula is calculated each blood pressure wave mode, average these a plurality of PMBP again:

PMBP(mean)＝SUM(PMBP)/N---------(3)

Wherein PMBP (mean) makes a living and pats the meansigma methods of equal blood pressure PMBP, and SUM (PMBP) is the summation of N PMBP, and N is the number of blood pressure wave mode.

19, a kind of application of non penetration type system for measuring radial artery blood pressure wave is characterized in that: it differentiates the identity step of testee:

The continuous blood pressure wave mode of the testee of acquisition one regular (as 50 seconds to 1 minute);

Find out the starting point (being trough) of each blood pressure wave mode, terminal point (being the starting point of next wave mode), and each wave crest point and trough point;

Calculate the crest number of each blood pressure wave mode, time, pressure, oblique angle, area, and standardization characteristic parameter value such as (Normalized);

Calculate the meansigma methods of these parameter values in test period, and they are defined as this testee blood pressure wave mode feature datum line (Characteristic Baseline);

Blood pressure wave mode characteristic ginseng value and aforesaid feature datum line with testee compare, if certain degree similarity (Similarity) is arranged, judge that then this testee is same people, otherwise are different people;

If there is group (for example more than two people) respectively to record earlier blood pressure wave mode feature datum line, in the future if wherein a people is with unidentified acceptance test, then can compare one by one according to the blood pressure wave mode characteristic ginseng value of this testee and indivedual data of this group, and select the similarity soprano, judge that according to this this testee is this known identities person; The similarity of above-mentioned so-called certain degree can be according to experiment and discriminating demand standard in addition.

20, non penetration type system for measuring radial artery blood pressure wave according to claim 19, it is characterized in that: it differentiates the identity step of testee, elder generation is with the time of (Normalized) after crest number in the parameter (being generally 1.0 to 3.0) and the standardization, pressure, the oblique angle, and the characteristic parameter value of area is defined as the emphasis parameter that meets similarity.

21, a kind of application of non penetration type system for measuring radial artery blood pressure wave is characterized in that: it measures the identity step of breathing wave mode and frequency:

(as 1～10 minute) captures the blood pressure wave mode of testee continuously and makes X-Y figure in the testing period, and wherein the X value is the time, and the Y value is voltage or pressure;

Find out the X value (being time value) and Y value (being voltage or force value) of the main wave crest point of each wave mode;

Make continuous XY figure, as the breathing wave mode of this testee;

Every regularly (as one minute) interior wave mode number (as eight) is calculated, and is respiratory frequency or Respiration Rate (as each minute eight breathings).

22, a kind of application of non penetration type system for measuring radial artery blood pressure wave is characterized in that: the symptom step of its monitoring cough or sneeze:

Capture the blood pressure wave mode of testee continuously;

Calculate testee three parameter values (time interval of promptly main crest-main crest of the blood pressure wave mode of interior (as a minute) in the early stage, the force value of main crest value, and the force value of main trough) meansigma methods and standard deviation, and with the meansigma methods definition datum line of three parameter values for this reason;

At any time monitor three parameter values of blood pressure wave mode at test period, if one of them departs from (containing above) more than the prior prearranged multiple (for example three times) of its datum line accurate deviation up to standard, then this wave mode is called suspicious irregular material point;

With irregular material point (do not have certain frequency) taking place at random, defines this material point and be cough or sneeze point; Statistics can obtain cough or sneeze frequency (as per minute three times).

23, a kind ofly be used for the novel physiological signal monitoring instrument system that hospital isolates sufferer, it is characterized in that: comprising:

The accurate blood pressure wave mode of the non-intrusion type measurement system that the request for utilization claim is the 1st;

The body temperature measurement technology, and temperature inductor placed on the wrist strap;

One group of wireless transmission transmitting-receiving module is placed in the main frame, and another group places to be responsible in the ward receiving in the bedside analyzer of sufferer physiological signal;

Isolate the heart beating of sufferer with aforesaid system measurements, blood pressure (systolic pressure, diastolic pressure, physiology mean blood pressure) is breathed wave mode and frequency, and judges whether had palpitation of sufferer, rapid breathing, cough or sneeze;

Measure the wrist body temperature of sufferer with aforementioned temperature inductor, and judge whether sufferer has a fever;

Above-mentioned physiological signal is sent to the bedside analyzer with the wireless transmission module by main frame;

With the bedside analyzer with sufferer physiological signal and analysis result thereof see through regional networking (Local Area Network, LAN) or the Internet (Internet) spread out of the ward.

24, according to claim 23ly be used for the novel physiological signal monitoring instrument system that hospital isolates sufferer, it is characterized in that wherein body temperature measurement technology, can use a low profile thermal galvanic couple, a resistance-type electronic component, or infrared ray electric device, the three is all thermal sensible element, body temperature can be converted to voltage or current signal.

25, according to claim 23ly be used for the novel physiological signal monitoring instrument system that hospital isolates sufferer, it is characterized in that wherein Radio Transmission Technology, can use RF (Radio Frequency) wireless module of general commercialization, its frequency range can be in ISM Band (i.e. [industry commonly used, science, medical treatment] band sharing).

26, a kind of instrument system that is used to monitor the house quarantine common people is characterized in that comprising:

The accurate blood pressure wave mode of the non-intrusion type measurement system that the request for utilization claim is the 1st;

With the aforementioned instrument system measurement house quarantine common people's heart beating, blood pressure (systolic pressure, diastolic pressure, mean pressure), the blood pressure wave mode is breathed physiological signals such as wave mode and frequency, and judges whether had palpitation of these common people in view of the above, violent blood pressure, rapid breathing, cough or sneeze;

Measure these common people's body temperature with existing body temperature measurement technology, and judged whether the fever symptom in view of the above;

The physiology information of inciting somebody to action with existing Radio Transmission Technology regularly reaches the signal receiving and analyzing device of putting in family;

With signal receiving and analyzing device the physiology information is stored, analysis regularly reaches health office with the Internet (Internet) transmission or phone data machine (Modem) after (or demonstration);

Regularly collect, arrangement, and not morbidity of statistics are fallen ill, and restorative isolation common people number.

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