CN1887238A - Stereo gecko brain locating method and device - Google Patents
Stereo gecko brain locating method and device Download PDFInfo
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- CN1887238A CN1887238A CNA200610086008XA CN200610086008A CN1887238A CN 1887238 A CN1887238 A CN 1887238A CN A200610086008X A CNA200610086008X A CN A200610086008XA CN 200610086008 A CN200610086008 A CN 200610086008A CN 1887238 A CN1887238 A CN 1887238A
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- 238000000034 method Methods 0.000 title claims abstract description 16
- 241001312741 Gekko swinhonis Species 0.000 claims description 76
- 210000003128 head Anatomy 0.000 claims description 26
- 210000004279 orbit Anatomy 0.000 claims description 23
- 210000001331 nose Anatomy 0.000 claims description 16
- 210000000537 nasal bone Anatomy 0.000 claims description 8
- 238000004826 seaming Methods 0.000 claims description 6
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Abstract
The stereo gecko brain locating method and device belongs to the field of locating technology. The present invention utilizes the unique condyles in the mandible joint and the maxilla joint as well as the maxilla site to determine one locating reference plane for locating the head of gecko completely. The corresponding device consists of locating needles, 3D electrode shifting unit, U-shaped seat, right and left eye rod holder, gecko adaptor, etc. The present invention has the features of accurate location and simple operation, and is suitable for the lab research of brain of reptile.
Description
Technical field
Stereo gecko brain locating method of the present invention and device belong to field of locating technology, are used for the three-dimensional positioning experiment of Gekko Swinhonis brain.
Background technology
21 century is the century of brain, understanding brain in zones of different function, obtain its EEG signals, all need microelectrode is inserted predetermined position exactly.Accurate solid locating method accurately and setting are the necessary instruments of realizing above-mentioned target.After experimental subject head and position finder are fixed to one another, on stereotaxic instrument, just can mark the target spot in the brain.Promptly can determine the position of neuromechanism with a three-dimensional coordinate.Distance on stereotactic system indication neuromechanism and three zero plane cross points or the skull between certain a bit (as fontanel point, lambda), according to the research needs, the brain structure location collection of illustrative plates of existing both at home and abroad various conventional animals (monkey, cat, rabbit, mice, rat, Cavia porcellus, etc.).According to the three-dimensional coordinate position shown in these collection of illustrative plates, electrode is inserted in the desired neuromechanism then, can positions acute or chronic experimentatioies such as guiding, stimulation, damage and injection.This type of stereotaxic instrument (or finder) has orthoscopic and equatorial two classes, and with orthoscopic use the most extensively and general.At present the stereotactic system of generally acknowledging is that Britain scholar Horsley and Clarke proposed in 1906 and finish.
Stereotaxic instrument is to make according to following principle:
1, utilize some sign of skull surface, as the fontanel point, the relative constant relation of positions such as lambda, sagittal suture, external auditory meatus and eye socket lower edge and brain surface and some structure of brain deep is so as to determining the locus of these intracranial structures from the outside.
2, utilizing the spatial coordinate principle, is the position of a certain structure in the unit regulation animal brain with the millimeter.
3,, the head of animal is firmly fixed (displacement error≤0.2mm) with firm, an accurate and monosymmetric head-clamp.Very high with one group of accuracy in addition, three slip chis that are mutually the right angle constitute electrode movable stand, accuracy of reading≤0.1mm.On the electrode movable stand, electrode holder is housed.Before and after can doing along three planes after electrode is loaded onto, about, move up and down, and can be by certain plane rotating certain angle, also can load onto various types of micro-thrusters on the slide rule moving up and down, make the precision that moves up and down higher, can read the precision of 1 μ m.
The stereotactic method of example explanation of orientating as below by two kinds of laboratory animals:
(1) the three-dimensional location of the brain of cat: according to the regulation of Horsley-Clarke, after Caput Felis domestica was fixing, two eye socket lower edge minimum points and both sides external auditory meatus central point coexisted on the horizontal plane, and this horizontal plane is parallel fully with the framework of instrument.The plane parallel imaginary plane of 10mm that makes progress is the horizontal zero plane thus; Line by two external auditory meatus centers and perpendicular to the crown vertical of the planar plane of horizontal zero for regulation fore-and-aft direction reading, by Caput Felis domestica portion median line, with vertical plane, horizontal zero plane be the sagittal zero plane.Load onto locating needle earlier, the peak (two eye socket lower edge minimum points) of regulating two eye socket brackets by three mobile slide rules and the mid point of the two ear bar lines of centres are on same level.After cat anesthesia, unscrew ear bar hold-down nut, take off the ear bar.The ear bar is inserted the external auditory meatus of cat respectively, and the left and right sides promotes the ear bar in opposite directions, and Caput Felis domestica is fixed, and makes two scale readings of picking up the ears on the bar identical, screws screw fixed ear bar then.To go up gnathostat and advance Caput Felis domestica, the hook that eye socket is drawn together is pressed in the minimum position of the eye socket lower edge of cat and is fixed.With tooth fixed bar structure between two big molars than the recess position, lift and tighten spiral on as far as possible.Push hard and shake Caput Felis domestica,, can open operations such as cranium if firmly motionless.According to the cat brain map, find the elements of a fix reading for the treatment of research structure, can the channeling conduct electrical activity or apply experiment such as stimulation.
(2) the three-dimensional location of rat brain: load onto the ear bar, go up gnathostat, electrode movable stand, adjust main frame, test contact position, two ear bar centers whether on the center line of the location of system to level.Load onto locating needle, the height with locating needle mensuration ear bar center moves on to electrode front tooth plate upper limb then, adjusts the front tooth plate than the low 5mm of biauricular line (it is fixed according to collection of illustrative plates that this adjusts fibrous root, be consistent with the method in the collection of illustrative plates).
The core point of stereotaxic instrument is that the location is reliable, repetitive positioning accuracy is high, and system rigidity is good.As can be seen from the above, realize three-dimensional location, at first will determine positioning reference plane.Promptly before and after (crown), about (sagittal), three datum planes of level.Secondly, be to determine the positioning clamping point, design firm, an accurate and monosymmetric head-clamp.Also need the accurate three-dimensional coordinate indication mechanism of a cover at last, realization is read the coordinate of relative three datum planes of required point.
The accessible motor capacity of Gekko Swinhonis three dimensions is becoming domestic and international research focus.But research emphasis adheres to mechanism and bionical at sole.We set about the research of its brain motor function at present.Yet also be not applicable to the brain solid positioner of Gekkonidae animal skull at present both at home and abroad.Laboratory animal commonly used as: mice, rat, Cavia porcellus, rabbit, cat, Canis familiaris L., pigeon etc. all have corresponding portion fixed adapter can not be used for Gekko Swinhonis.Position finder is traditionally realized the three-dimensional location of the brain of different animals with different adapters by changing the ear bar.As domestic gulf, river II type commonly used, auspicious fertile general Stereotaxic apparatus such as MP8000 type.Rat, high mammal such as mice, cat and birds all have external auditory meatus completely, can locate with (ear rod).And Gekko Swinhonis external auditory meatus does not still form, can't be as localized benchmark.Therefore, must determine the mental body localization method of Gekko Swinhonis, development clamping head-clamp.
Summary of the invention
The objective of the invention is to, propose a kind of stereo gecko brain locating method and device, realize the three-dimensional location of brain of Gekko Swinhonis, accurate positioning, flexible and convenient operation.
Anatomical research shows, Gekko Swinhonis does not have the external auditory meatus that is shaped, can not resemble to position by external auditory meatus the mammals such as rat, rabbit, cat.But two eye socket trailing edges have uniqueness near the joint structure of mandibular bone and upper jaw bone articulation place about Gekko Swinhonis, can locate and clamping.This two place is in case the location has then guaranteed Gekko Swinhonis skull left and right horizontal and centering.By the clamping of upper jaw bone point position, 3 unique definite location datum planes are completely fixed the Gekko Swinhonis head again.According to experiment statistics, during the docile and obedient naturally horizontal plane of the gecko head of growing up, nose point generally hangs down about 5mm than fontanel point.
According to above principle, method of the present invention and install as follows:
A kind of stereo gecko brain locating method adopts three positioning feature point method of clamping, it is characterized in that may further comprise the steps:
(1), anesthesia Gekko Swinhonis, make the docile and obedient naturally horizontal plane of its head, measure the relative altitude d of its head fontanel point and nose point under this state, measurement error is less than 0.1mm;
(2), with images of left and right eyes rod holder clamping Gekko Swinhonis left eye socket of the eye bite and right eye socket of the eye bite, and adjust left and right eyebar relative position, make left eye socket of the eye bite and right eye socket of the eye bite maintenance level and centering, wherein left and right sides eye socket bite particular location is: the maxillary teeth lower end of Gekko Swinhonis left and right sides eye socket trailing edge and close upper and lower jawbone articulation place; Reuse Gekko Swinhonis adapter clamping Gekko Swinhonis upper jaw bite;
(3), tentatively regulate images of left and right eyes rod holder and Gekko Swinhonis adapter, the state consistency when making the docile and obedient horizontal plane of Gekko Swinhonis brain location and Gekko Swinhonis naturalness head portion;
(4), determine that level reference, sagittal plane and coronal plane are as three work plane of references: with fontanel point, nose point is index point; the point of getting the vertically above height d of nose point place is fixed point; by this fix a point and the line of fontanel point as normal line, comprise that this line and the plane parallel with two eyebars are level reference; Comprise normal line and be the sagittal plane perpendicular to the plane of level reference; Is coronal plane by fontanel point perpendicular to the plane of level reference and sagittal plane;
(5), utilize locating needle and three-diemsnional electrode mobile device, carry out bite and proofread and correct: regulate the Gekko Swinhonis adapter position earlier, make the nose point highly, parallel with the horizontal plane of position finder with the level reference of assurance Gekko Swinhonis head than the low d of fontanel point; Re-adjustment Gekko Swinhonis head just coincides the most advanced and sophisticated track of locating needle with the line of Gekko Swinhonis nose point and Gekko Swinhonis fontanel point.
A kind of stereo gecko brain positioner, comprise locating needle, three-diemsnional electrode mobile device, base, be installed in U-shaped bearing on the base, be installed in being positioned at of U-shaped bearing U font two ends respectively with left clamper on the bar horizontal line and right clamper, be installed in the adapter of U-shaped bearing U font bottom and vertical and left and right clamper axis, and described left clamper, right clamper and adapter all are provided with vernier graduation, it is characterized in that:
(1), described left clamper is by the left eye bar, form by the left eye bar upper grip that lock-screw, lock-screw and back-moving spring and left eye bar cramp are tight, and the clamping end face of left eye bar upper grip has a circular arc cutaway;
(2), described right clamper structure and left clamper are identical;
(3), described adapter is made up of vertical moving-member and upper jaw clamper, and the nasal bone seaming chuck that described upper jaw clamper clamps by upper jaw lower chuck, by lock-screw, lock-screw and back-moving spring and upper jaw lower chuck is formed, and upper jaw lower chuck is provided with the cylinder pressure head.
Left and right clamper of the present invention has another name called the images of left and right eyes rod holder, the end dead in line of right and left eyes rod holder lower chuck, and clamping face is on the same horizontal plane on two eyebars.The position of left and right sides eyebar is guaranteed by the vernier graduation on the eyebar, makes Gekko Swinhonis left and right sides eye socket bite maintenance level and centering.Gekko Swinhonis left and right sides inferior orbit trailing edge is by the upper grip clamping of right and left eyes rod holder.The design of upper grip bite is fluted, and not only reliable clamping, and difficult drop-off do not cause damage to Gekko Swinhonis.
Adapter of the present invention has another name called the Gekko Swinhonis adapter, is used for the clamping of the Gekko Swinhonis upper jaw.Reliable for clamping, and do not damage the Gekko Swinhonis upper jaw, in the upper jaw lower chuck Front-end Design small cylindrical pressure head is arranged, be used to block Gekko Swinhonis rhynchodaenm upper jaw bone.Because the closely-pitched of the Gekko Swinhonis upper jaw, and the natural inclined plane of Gekko Swinhonis rhynchodaenm nasal bone make the upper jaw under the chucking power of last lower chuck, clamping does not naturally reliably come off and does not cause damage.Consider that the state when making Gekko Swinhonis brain location as far as possible with the docile and obedient ground of Gekko Swinhonis naturalness head portion is consistent, but upper jaw lower chuck is designed to a mechanism level and up-down adjustment, is equipped with the vernier graduation chi.Regulate upper jaw lower chuck and can regulate the index point-fontanel point of Gekko Swinhonis skull surface and the relative altitude of nose point, the clamping location is met the demands.
Description of drawings
Fig. 1 is a stereo gecko brain positioner sketch map.
Fig. 2 is the structural representation of eyebar clamper.Wherein (a) is the top view sketch map; (b) for overlooking the observation sketch map.
Fig. 3 is the structural representation of Gekko Swinhonis adapter.Wherein (c) is the top view sketch map; (d) for overlooking the observation sketch map.
Fig. 4 is the location and the bite sketch map of Gekko Swinhonis head position.Wherein (e) is the top view sketch map; (f) for overlooking the observation sketch map.
Label title among Fig. 1: 1-left eye bar clamp-screw; 2-left eye rod holder; 3-right eye rod holder; 4-right eye bar clamp-screw; The 5-base; 6-U shape bearing; 7-adapter clamp-screw; 8-Gekko Swinhonis adapter.
Label title among Fig. 2: 9-lock-screw; 10-eyebar upper grip; The 11-eyebar; The 12-back-moving spring; The 13-lock-screw.
Label title among Fig. 3: 14-joint cover; The 15-screw; The 16-fixed support; 17-moves up and down frame; The 18-set lever; The 19-Connecting jont; The 20-lock-screw; The 21-back-moving spring; 22-upper jaw lower chuck; 23-cylinder pressure head; 24-nasal bone seaming chuck; The 25-lock-screw; The 26-lock-screw; The 27-lock-screw.
Label title among Fig. 4: 28-fontanel point 29-nose point 30-upper jaw bite 31-left and right sides eye socket trailing edge bite.
The specific embodiment
Fig. 1 is a stereo gecko brain positioner sketch map.As shown in the figure, U-shaped bearing 6 is fixed on the base 5 by three pillars.Images of left and right eyes rod holder 2 and 3 links by eyebar clamp-screw 1,4 and U-shaped bearing 6 respectively.Can regulate the mutual alignment of images of left and right eyes rod holder 2 and 3 by two eyebar clamp-screws of turn 1,4.Gekko Swinhonis adapter 8 links by adapter clamp-screw 7 and U-shaped bearing 6.Turn adapter clamp-screw 7 can be regulated the position that overhangs on U-shaped bearing 6 of Gekko Swinhonis adapter 8.
Fig. 2 is the assembly structure figure of images of left and right eyes rod holder.As shown in the figure, be drilled with a through hole and a blind hole on the eyebar upper grip 10, lock-screw 9 and 13 links by two screwed holes on these two holes and the eyebar 11, regulates lock-screw 13 to suitable elongation, screws lock-screw 9 then and just can realize easily clamping.Under back-moving spring 12 ground elastic force effects, unscrewing lock-screw 9 eyebar upper grips 11 can lift naturally, removes to clamp.
Fig. 3 is the structural representation of Gekko Swinhonis adapter.As shown in the figure, the Gekko Swinhonis adapter utilizes adapter clamp-screw 7 to be connected with U-shaped bearing 6 by connecting plate 14.Fixed support 16 connects firmly together with connecting plate 14 by two soket head cap screws 15.Moving up and down frame 17 has the dovetail groove of the upward and downward on dovetail structure and the fixed support 16 to match, can be along fixed support 16 adjusting that moves up and down.Fixed support 16 indicates vernier graduation (Fig. 3, B is to view) with the side that moves up and down frame 17.The Gekko Swinhonis upper jaw is consolidated the clamping device principle with the images of left and right eyes rod holder, by lock-screw 20,25, and back-moving spring 21, upper jaw lower chuck 22, cylinder pressure head 23, nasal bone seaming chuck 24 compositions such as grade.Gekko Swinhonis upper jaw clamping device connects by lock-screw 26 and connector 19; Connector 19 again by set lever 18 with move up and down frame 17 and connect mutually.
With a specific embodiment the inventive method is described below in conjunction with Fig. 1, Fig. 2, Fig. 3, Fig. 4.
1, with after the Gekko Swinhonis anesthesia, raise scalp and expose fontanel point 28 and nose point 29, measure its head 2 highly vertical relatively under the docile and obedient state of natural level, to measure and average for 3 times, precision is 0.1mm.
2, open lower jaw on it gently, its corners of the mouth is opened; Unscrew left and right two eyebar lock-screws 1,4, the upper grip clamp-screw 9,13 of outwarding winding puts in the corners of the mouth with left and right sides eyebar, is keeping making corners of the mouth root (do not oppress skull, do not make its distortion) withstand the medial surface of left and right eyebar under the naturalness.Regulate left and right two eyebar upper grips 10 then, make it can block the left and right inferior orbit trailing edge of Gekko Swinhonis fully.Revolve left and right two eyebar lock-screws 9 at last gently, regulate simultaneously two eyebar scales to about complete symmetry, screw two eyebar lock-screws 1,4 then.
3, it is sharp-tongued the cylindrical pressure head 23 of the upper jaw lower chuck 22 of Gekko Swinhonis adapter 8 to be put in Gekko Swinhonis, screw the lock-screw 25 of nasal bone seaming chuck 24 gently, make it push down nasal bone, note simultaneously gently pulling on jaw clamping device (20,21,22,23,24,25) forward, make the anterior closely-pitched of Gekko Swinhonis upper jaw inboard just block the cylinder pressure head 23 on the upper jaw lower chuck 22 and do not come off.
4, tentatively regulate left eye rod holder 2, right eye rod holder 3 and Gekko Swinhonis adapter 8, the state basically identical when making the docile and obedient horizontal plane of Gekko Swinhonis brain location and Gekko Swinhonis naturalness head portion;
5, load onto locating needle, regulate the three-diemsnional electrode mobile device, make the school needle tip just aim at Gekko Swinhonis fontanel point 28, regulate Gekko Swinhonis upper jaw bite 30 earlier, make nose point 29 than fontanel point 28 low suitably height, the level reference of Gekko Swinhonis head is paralleled with the horizontal plane of position finder.Height value is the 1st step institute's measured value.Move forward and backward locating needle then, regulate the Gekko Swinhonis head, the most advanced and sophisticated track of locating needle is just coincided with Gekko Swinhonis nasal bone and parietal bone binding site (nose point 29) and the line of Gekko Swinhonis fontanel point 28.Then carefully screw the upper grip 10 of left and right sides eyebar.Clamp nasal bone seaming chuck 24 at last again.This moment, the Gekko Swinhonis head just was completely fixed in above the brain solid positioner.
According to experiment statistics, during the docile and obedient naturally horizontal plane of the Gekko Swinhonis that body weight is identical, head, nose point 29 is with the relative altitude difference basically identical of fontanel point 28, thus in the actual experiment, can according to claim body weight result, omit the first step with reference to historical data.
With three-dimensional locating and clamping apparatus of the present invention: images of left and right eyes rod holder 2,3 and Gekko Swinhonis adapter 8 are installed on the commercial brain solid positioner, show by practical operation, and this clamping localization method and device can satisfy our experiment needs fully.Even if take off Gekko Swinhonis, as long as remember previous Gekko Swinhonis fontanel point coordinates, next repetitive positioning accuracy also can satisfy requirement of experiment.
Claims (3)
1, a kind of stereo gecko brain locating method adopts three positioning feature point method of clamping, it is characterized in that may further comprise the steps:
(1), anesthesia Gekko Swinhonis, make the docile and obedient naturally horizontal plane of its head, measure the relative altitude d of its head fontanel point and nose point under this state, measurement error is less than 0.1mm;
(2), with images of left and right eyes rod holder clamping Gekko Swinhonis left eye socket of the eye bite and right eye socket of the eye bite, and adjust left and right eyebar relative position, make left eye socket of the eye bite and right eye socket of the eye bite maintenance level and centering, wherein left and right sides eye socket bite particular location is: the maxillary teeth lower end of Gekko Swinhonis left and right sides eye socket trailing edge and close upper and lower jawbone articulation place; Reuse Gekko Swinhonis adapter clamping Gekko Swinhonis upper jaw bite;
(3), tentatively regulate images of left and right eyes rod holder and Gekko Swinhonis adapter, the state consistency when making the docile and obedient horizontal plane of Gekko Swinhonis brain location and Gekko Swinhonis naturalness head portion;
(4), determine that level reference, sagittal plane and coronal plane are as three work plane of references: with fontanel point, nose point is index point; the point of getting the vertically above height d of nose point place is fixed point; by this fix a point and the line of fontanel point as normal line, comprise that this line and the plane parallel with two eyebar common axis lines are level reference; Comprise normal line and be the sagittal plane perpendicular to the plane of level reference; Is coronal plane by fontanel point perpendicular to the plane of level reference and sagittal plane;
(5), utilize locating needle and three-diemsnional electrode mobile device, carry out bite and proofread and correct: regulate Gekko Swinhonis Gekko Swinhonis adapter position earlier, make the nose point highly, parallel with the horizontal plane of position finder with the level reference of assurance Gekko Swinhonis head than the low d of fontanel point; Re-adjustment Gekko Swinhonis head just coincides the most advanced and sophisticated track of locating needle with the line of Gekko Swinhonis nose point and Gekko Swinhonis fontanel point.
2, a kind of stereo gecko brain positioner, comprise locating needle, three-diemsnional electrode mobile device, base (5), be installed in U-shaped bearing (6) on the base (5), be installed in being positioned at of U-shaped bearing (6) U font two ends respectively with left clamper (2) on the bar horizontal line and right clamper (3), be installed in the adapter (8) of U-shaped bearing (6) U font bottom and vertical and left and right clamper axis, and described left clamper (2), right clamper (3) and adapter (8) all are provided with vernier graduation, it is characterized in that:
(1), described left clamper (2) is by left eye bar (11), form by the left eye bar upper grip (10) that lock-screw (9), lock-screw (13) and back-moving spring (12) and left eye bar (11) clamp, and the clamping end face of left eye bar upper grip (10) has a circular arc cutaway;
(2), described right clamper (3) structure and left clamper (2) are identical;
(3), described adapter (8) is made up of vertical moving-member and upper jaw clamper, and the nasal bone seaming chuck (24) that described upper jaw clamper clamps by upper jaw lower chuck (22), by lock-screw (20), lock-screw (25) and back-moving spring (21) and upper jaw lower chuck (22) is formed, and upper jaw lower chuck (22) is provided with cylinder pressure head (23).
3, Gekko Swinhonis brain body positioner according to claim 2 is characterized in that: described vertical moving-member by fixed support (16), link to each other with fixed support (16) move up and down frame (17), by set lever (18) with move up and down the Connecting jont (19) that frame (17) links to each other and form.
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| CNB200610086008XA CN100506187C (en) | 2006-07-19 | 2006-07-19 | Stereo gecko brain locating method and device |
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| CNB200610086008XA CN100506187C (en) | 2006-07-19 | 2006-07-19 | Stereo gecko brain locating method and device |
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| CN100506187C CN100506187C (en) | 2009-07-01 |
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