CN1872342A - Process for preparation of granular oral composition using oligosaccharide solution - Google Patents
Process for preparation of granular oral composition using oligosaccharide solution Download PDFInfo
- Publication number
- CN1872342A CN1872342A CNA2006100783280A CN200610078328A CN1872342A CN 1872342 A CN1872342 A CN 1872342A CN A2006100783280 A CNA2006100783280 A CN A2006100783280A CN 200610078328 A CN200610078328 A CN 200610078328A CN 1872342 A CN1872342 A CN 1872342A
- Authority
- CN
- China
- Prior art keywords
- oral composition
- oligosaccharide
- manufacture method
- raw material
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Emergency Medicine (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Disclosed is a granular oral composition which can be shaped (granulated) by using a solution of an oligosaccharide as a binder without the need of using any binder other than the oligosaccharide in the shaping (granulation) of a powdery material for oral use and which shows a good feeling in the mouth when suspended and unsuspended in a liquid. An oligosaccharide is dissolved in a spray solution to be used in the flow bed granulation method and the resulting solution is sprayed onto a powdery material for oral use, whereby the material for oral use can be granulated using the oligosaccharide as a binder.
Description
Technical field
The present invention relates to do that binding agent carries out pelletize to Powdered per os raw material and the oral composition and the manufacture method thereof that obtain with oligosaccharide solution.
Background technology
Along with the raising of its people to the health concerns degree, the trial of keeping fit by the food of daily picked-up has caused everybody gazing at.Wherein, the various exploitations that contain the Powdered per os raw material of functional components in the organism are very active; the finished product that these raw materials are made into different shape offers consumer, and the food that especially provides with the granule form, be dissolved or dispersed in earlier in the oral administration liquid before taking is popular.
But, when Powdered per os raw material is made granule (pelletize), have following problem: Powdered per os raw material self lacks cohesiveness mostly, even make its molding (pelletize) by wet granulation method etc., also damaged, cracked easily in manufacture process and circulation of commodities process, in addition, even upward out of question in molding (pelletize), the mouthfeel during liquid suspension is bad.As solution to the problems described above, can consider to use binding agent, described in patent documentation 1 grade, be widely used as known technology.Promptly, as everyone knows, during Powdered per os raw material pelletize there be widely used binding agent: hyprolose, hydroxypropyl methylcellulose, methylcellulose, carboxymethyl cellulose, amylopectin, starch, dextrin, guar gum etc., and use these binding agents can obtain good granule.
But use binding agent to have following problem: the content of functional components reduces in the organism that cooperates in a granule, and the amount of the granule of once taking in is increased.In addition,, compare, only use the granule of the per os feedstock production of functional components in the organism that contains desired picked-up favored by consumer as far as possible with the granule that has added binding agent from the health of consumer and the angle of hobby.For example: do not use the manufacture method that contains the erithritol granule (patent documentation 2) of binding agent, the preparation (patent documentation 3) that only obtains etc. with the pelletize of crude drug composition, under the situation of not adding binding agent, can make the technology of a part of powder compacting (pelletize) become known technology, but these technology can't be widely used in most of per os powder stocks.
On the other hand, in vivo in the functional components, be known as the saccharide of oligosaccharide and physiologically active that catabolite has thereof and caused people's attention in digestive tract, obtain broad research in recent years.Known: oligosaccharide picked-up back plays a role the useful bacterium bacillus bifidus of selective proliferative enteral at large intestine; In addition, oligosaccharide has good sweet taste, therefore, can utilize oligosaccharide to improve the taste (with reference to patent documentation 4, patent documentation 5) of various food; And oligosaccharide has the characteristic of meeting the easy moistening of water, adds oligosaccharide during molding in binding agent complementaryly, helps to improve formability (patent documentation 6).
But known oligosaccharide of no use is made binding agent Powdered per os raw material is made the report of granule (pelletize), also not about the report of the mouthfeel of the granule that makes according to the method described above.
[patent documentation 1] Japanese kokai publication hei 7-188058
[patent documentation 2] TOHKEMY 2000-119173
[patent documentation 3] TOHKEMY 2004-160165
[patent documentation 4] Japanese kokai publication hei 10-210957
[patent documentation 5] TOHKEMY 2004-161701
[patent documentation 6] PCT WO00/48575
Summary of the invention
The present invention in Powdered per os material forming (pelletize) by making binding agent with oligosaccharide solution, not only can be at the situation compacted under (pelletize) that does not use the binding agent beyond the oligosaccharide, when also providing liquid suspension and liquid is non-has the graininess oral composition of good taste when suspending.
So, the inventor how to have concentrated on studies with have a useful function in the organism and be that the raw-food material that picked-up is thirsted for by consumer makes Powdered per os material forming (pelletize), found that: make binding agent with oligosaccharide solution, not only fully molding (pelletize), the graininess oral composition that anelasticity is improved in the oral cavity that good mouthfeel and liquid are non-when also having obtained liquid suspension when suspending.
That is, the present invention carries out pelletize to Powdered per os raw material and the manufacture method of the granular oral composition that obtains with oligosaccharide solution.
The oral composition that the present invention relates to can be used as the ingesta picked-up again by making as binding agent with oligosaccharide solution in Powdered per os raw material.
According to the present invention, by in Powdered per os raw material, making binding agent with oligosaccharide solution, not only can be at the situation compacted under (pelletize) that does not use the binding agent beyond the oligosaccharide, the graininess oral composition that anelasticity is improved in the oral cavity that good mouthfeel and liquid are non-in the time of can also providing liquid suspension when suspending.And, oral composition taking convenience of the present invention, and consumer wishes that the picked-up of the composition beyond the composition that absorbs reduces.In addition, oral composition of the present invention has the whole intestinal effect of oligosaccharide, and the health of consumer is highly profitable.
The specific embodiment
Oligosaccharide used in the present invention is all lacked sugar chain by a plurality of monosaccharide with glycosidic bond be combined into (preferably by 2 to 10 monosaccharide be combined intos) no matter be homogeneity oligosaccharide or heterooligosaccharide.For example: Raffinose, palatinose, lactose, lactulose, LS 55L, stachyose, oligofructose, galactooligosacchari(es, commentaries on classics galactooligosacchari(es, Radix Gentianae oligosaccharide, fruit oligose, nigero-oligosaccharide, xylooligosaccharide, Fructus Hordei Germinatus oligose, cell-oligosaccharide, para gold oligosaccharide, isomalto Oligosaccharide and soy oligosaccharide.These oligosaccharide can 2 kinds or are used in combination greater than 2 kinds, also can use in the d body l body any one.Wherein, preferred xylooligosaccharide.
Xylooligosaccharide be meant with the homogeneity polysaccharide-xylan (hemicellulose) that obtains from corncob, cotton seed hulls etc. be raw material, by the oligosaccharide of a plurality of xyloses with β-1,4 glycosidic bond be combined into, its for white, light sweet taste, the crystalline powder of odorless arranged.For example, the commercially available product of the employed commodity of the applicant " xylooligosaccharide 95P " by name, effect is fine.
The oligosaccharide that uses in the method for the present invention is solution state, preferably also brings into play the effect of spray liquid in the effect of performance binding agent.The solvent of dissolving oligosaccharide is an aqueous solvent, for example water or aquiferous ethanol.Oligosaccharide concentration in the oligosaccharide solution be so long as can bring into play the binding agent effect simultaneously and the concentration of pelletize water effect gets final product, and can easily select according to the kind of used oligosaccharide and Powdered per os raw material that will pelletize.Preferred 5～40 weight % of oligosaccharide concentration when for example, containing the pelletize of dietary fiber material.
According to cooperating purpose can determine the appropriate level of above-mentioned oligosaccharide usual amounts in the oral composition, preferred 0.1～30 weight % of oligosaccharide total amount, more preferably 1～20 weight %, especially preferred 3～15 weight %.At this moment, when absorbing the oral composition that obtains by the inventive method pelletize, be that adult everyone 0.1～10g, preferred 0.3～0.8g decide according to the oligosaccharide intake owing to specific purpose.
It is functional and per os is taken in and by the absorbed in vivo raw material of digestive tract that per os raw material of the present invention is that raw material with effect of diet product, health food, pharmaceuticals promptly has in the organism.When the per os raw material was Powdered, Yin Qiyi dispersed, and operation and oral inconvenience and in order to make its easy picked-up, are made into liquid state sometimes, but also have following variety of issue: when its in aqueous solvent during insoluble or indissoluble, dissolving need expend a lot of times etc.Particularly concerning child and old man, the problems referred to above are more serious, need carry out pelletize and make it easy to utilize.When per os raw material when not being Powdered, also can in all sorts of ways earlier is made into 75 μ m or less than the powder of 75 μ m, reuse method pelletize of the present invention.
The Powdered per os raw material that carries out pelletize among the present invention is not had particular restriction, but the inventive method is specially adapted to contain the per os raw material of water insoluble active ingredient.Water insoluble active ingredient can be fatsoluble vitamin, insoluble dietary fiber etc., as the per os raw material that contains these compositions, for example, contains the dietary fiber raw material.Mainly acting as of dietary fiber increases stool weight, influences each digestive organs, influences the metabolism of nutritional labeling etc., in these physiologically actives, especially in the association area of protein metabolism, lipid metabolism, carbohydate metabolism, carried out many researchs.And in recent years, the research of the physiological action of intestinal bacteria has also been received concern about dietary fiber.Dietary fiber mainly is present in parts such as the leaf that contains the Plant fiber, bud, stem, flower, fruit, root, fringe, seed, is typically the green plants powder.
The green plants powder more preferably is used for making the raw-food material of blue or green juice, for example, and the mixture of one or more in angelica keiskei koidzumi powder, wheat tender leaf powder, green tea powder, the Brassica Oleracea var. acephala powder.In many documents such as TOHKEMY 2003-334046, TOHKEMY 2003-79339, also put down in writing the example of other utilizable green plantss.
According to Japanese kokai publication sho 59-154935, Japanese kokai publication hei 2-231057 etc., the known method that various manufacturing angelica keiskei koidzumi powders are arranged, but angelica keiskei koidzumi powder has nothing to do with its manufacture method so long as the exsiccant angelica keiskei koidzumi powder of process gets final product.Angelica keiskei koidzumi is the Umbelliferae herbaceos perennial, in the middle part, Japanese Honshu and Northeast side offshore area, the regional Pacific Ocean cultivation is arranged.Angelica keiskei koidzumi contains multiple Coumarins, chalcone and antioxidant vitamins, and is effective in cure to arteriosclerosis, constipation and anemia.Use position to angelica keiskei koidzumi does not have particular restriction, and all sites such as leaf, bud, stem, fruit all can use.
According to (Japanese kokai publication hei 7-241176, TOHKEMY 2001-112435, TOHKEMY 2002-58449, TOHKEMY 2002-212, TOHKEMY 2003-9812, TOHKEMY 2003-178) such as known documents, the known method that various manufacturing wheat tender leaf powder are arranged, but wheat tender leaf powder has nothing to do with its manufacture method so long as the exsiccant wheat tender leaf powder of process gets final product.The wheat tender leaf is the tender leaf of wheat and barley, specifically can be the tender leaf of Fructus Hordei Vulgaris, Semen Tritici aestivi, rye (Secale cereale L.), Herba bromi japonici, Semen Coicis etc.The wheat tender leaf is rich in vitamins, minerals, dietary fiber etc., it suppresses as having that harmful substance absorbs, improves the enteral environment, suppresses cholesterol absorption, prevents that blood glucose value rises rapidly after meal, the raw material of the health food of the effects such as (SOD) that activates superoxide dismutase, has been subjected to extensive concern.
According to (TOHKEMY 2002-186445, TOHKEMY 2002-125612, TOHKEMY 2002-119245, TOHKEMY 2002-119239, TOHKEMY 2002-112729, TOHKEMY 2002-112701, TOHKEMY 2002-85010) such as known documents, the known method that various manufacturing Brassica Oleracea var. acephala powders are arranged, but Brassica Oleracea var. acephala powder has nothing to do with its manufacture method so long as the exsiccant Brassica Oleracea var. acephala powder of process gets final product.Brassica Oleracea Var.Acephala is a Cruciferae Btassica herbaceos perennial, and former is improving the breed of Brassica oleracea L.var.capitata L..Contain many vitaminss in the leaf, can prevent gastritis and gastric ulcer, improve liver function and constipation.For example can use various Brassica Oleracea Var.Acephalas such as Siberia type Brassica Oleracea Var.Acephala, Scotland type Brassica Oleracea Var.Acephala, gramme rad type Brassica Oleracea Var.Acephala.
Carry out not needing to contain binding agent commonly used in the Powdered per os raw material of pelletize, but can contain the binding agent of from hyprolose, hydroxypropyl methylcellulose, methylcellulose, carboxymethyl cellulose, amylopectin, starch, dextrin, guar gum, selecting as required.The solid formation that the content of the binding agent beyond the oligosaccharide is converted into the oral composition after the pelletize is divided into 0～2 weight %.As required, carry out to contain additive or auxiliary element commonly used in the food in the Powdered per os raw material of pelletize.For example can contain: sweet taste material such as erithritol, xylitol, sorbitol, mannitol, Palatinitol, maltose alcohol, lactose, arabinose, galactose, glucose, fructose, aspartame's sugar, Sucralose, stevioside; Reinforcing agents such as vitamins, anthocyanidin, isoflavone, chalcone derivative, catechin, lycopin, phylloxanthin, astaxanthin, rutin.Wherein, add antioxidant content-enzyme modification rutin and can improve food value, the solid formation that its addition is converted into the oral composition after the pelletize is divided into 0.1～10 weight %.
To be rutin and rutin analog handle and material after the glucosidesization through enzyme the enzyme modification rutin, and the rutin analog can be Quercetin, isoquercitin, Morin, myricetrin, myricetin etc.The enzyme modification rutin can obtain with the method for putting down in writing among Japanese kokai publication hei 7-10898, the TOHKEMY 2003-33164, except that the enzyme modification rutin, can also contain additive used on the galenic pharmacy.According to enzyme modification rutin intake is that be grown up 5mg～500mg for each person every day, preferred 10mg～300mg can determine the content of enzyme modification rutin in the compositions.
Granulating working procedure in the inventive method can adopt any means such as extruding pelletization method, fluidized bed comminution granulation, preferably can obtain the particulate fluidized bed comminution granulation of good mouthfeel.
During pelletize, with Powdered per os raw material and employed as required additive or the mixing of auxiliary element input fluidized bed pelletizer.Powdered per os raw material spraying in the moving layer of preparation 5～40 weight % oligosaccharide aqueous solution co-current flows comminutor.Service conditions such as the temperature during pelletize, air quantity can be set arbitrarily.
As required, make the particle that makes by said method, obtain oral composition by No. 16 sieve (mesh 1000 μ m) granulate.In oral composition of the present invention, the fine powder ratio of sieving (mesh 45 μ m) by No. 325 is 50 weight % of total amount or is lower than 50 weight %, preferred 25 weight % or is lower than 25 weight %.Can the oral composition behind the granulate is packed, and packaging operation be simple according to the application target difference.
The oral composition that is obtained by the present invention is the granule that is difficult for dispersing, and be easy to it is suspended in the liquid before taking, and the mouthfeel of float is good when drinking.The waterborne liquid that supending is used can also be milk beverage, refreshment drink, alcoholic beverage etc. so long as can oral uptake get final product do not have particular restriction beyond dewatering.Above-mentioned oral composition has the following advantages: it is not floated on a liquid but directly with after the graininess picked-up, its intraoral anelasticity is improved, it is very convenient to absorb.
The preferred configuration of oral composition of the present invention is the granular dietary fiber food that contains.Contain dietary fiber food and can have the explanation relevant with its function.Illustration method to function does not have particular restriction, for example can be in packaging for foodstuff, vessel surface, food description, advertisement for foods etc. referential function.
The present invention contains the function that dietary fiber food had to be had: the symptom of preventing and improve arteriosclerosis, anemia, gastritis, gastric ulcer, constipation, improve liver function, suppress harmful substance absorption, improve the enteral environment, has fat-reducing effect, suppress cholesterol absorption, prevent that blood glucose value rises rapidly after meal, the activation superoxide dismutase, with the bacillus bifidus proliferation activity is the whole intestinal effect of representative, the prevention colorectal cancer promotes mineral to absorb, based on the function of antioxidation.
Below, the present invention will be described in conjunction with the embodiments, but these embodiment do not limit the present invention.
[embodiment]
Embodiment 1～3
With xylooligosaccharide, fruit oligose, angelica keiskei koidzumi powder, tender leaf of Fructus Hordei Vulgaris powder, matcha powder, enzyme modification rutin, maltose alcohol, eggshell calcium, Antler Mythic Fungus powder as Powdered per os raw material; in fluidized bed pelletizer (manufacturing of FD-LAB-1 (strain) POWREX company); make spray liquid with any one solution in 30 weight % xylooligosaccharide solution, 3 weight % hyprolose (HPC) solution, water, the 30 weight % fruit oligose solution, the about 300g of the mixed-powder shown in the his-and-hers watches 1 has carried out pelletize.Drop into mixed-powder, mixes after 3 minutes, pelletize 10～20 minutes when the speed of dividing with 1.0～1.5ml/ with the spray liquid shown in the table 1 is sprayed (the product temperature: 35 ℃～40 ℃, suction temperature: 50 ℃～60 ℃).In same device, after dry 15～20 minutes, take out the pelletize thing, make it pass through No. 16 sieves (mesh 1000 μ m), obtain granule.
As the index of pelletize, estimate the ratio of fine powder, the result is displayed in Table 1.That is, the ratio of fine powder by No. 325 sieves (mesh 45 μ m) is 25 weight % of total amount or represents with zero when being lower than 25 weight %, 50 weight % or represent usefulness * expression during above 50 weight % with △ when being lower than 50 weight %.This is that convenience when taking according to granule and the mouthfeel when drinking are set.
Test example 1～3
Allow the granule that makes among 5 oral embodiment 1～3 of experimenter and in water, suspend after suspension, estimate mouthfeel (harsh feeling, no aftertaste).During evaluation, the expression mouthfeel was very bad in 3 minutes, the expression mouthfeel was bad in 2 minutes, the expression mouthfeel was all right in 1 minute, and the expression mouthfeel was good in 0 minute, 5 experimenters' of statistics evaluation score, when average mark is 3 minutes or is lower than 3 fens and surpasses 2 timesharing usefulness * expressions, 2 minutes or be lower than 2 fens and surpass 1 timesharing and represent that with △ 1 minute～0 timesharing represents that with zero the result is displayed in Table 1.
[table 1]
*: all make aqueous solution and spray.
The test example 1,2 in, shown in the result of sample number into spectrum 1,5, xylooligosaccharide with powder-mixed after the pelletize of reuse water, the gained granule is coarse, can not obtain the granule of good mouthfeel.And carry out pelletize as spray liquid with xylooligosaccharide solution, with only to carry out pelletize (sample number into spectrum 2,6) with hyprolose (HPC) solution the same, can obtain all granules of improved good mouthfeel (sample number into spectrum 3,7) of harsh feeling and no aftertaste.In addition, when carrying out pelletize as spray liquid, add a small amount of hyprolose (HPC) solution, can obtain the granule that pelletize is good and mouthfeel is good (sample number into spectrum 4) with xylooligosaccharide solution.
That is, not to make binding agent with HPC but carry out pelletize as spray liquid with xylooligosaccharide solution, can obtain the granule that pelletize is good and mouthfeel is good.
In test example 3, shown in the result of sample number into spectrum 9～11, adopt in xylooligosaccharide solution and the fruit oligose solution any one, all can obtain the granule of good mouthfeel.
Embodiment 4 (granule Production Example)
Made granule with technology of the present invention.The input amount of granulating working procedure is 100kg, after each composition shown in the table 2 is crossed No. 16 sieves (mesh 1000 μ m), drops into fluidized bed pelletizer (Flow coater200 type, FREUND industry (strain) company make).After having carried out preliminary flow, carry out pelletize in about 30 minutes (delivery temperature: about 40 ℃, suction temperature: 60 ℃) when spraying with the speed of about 800ml/ branch with 30 weight % xylooligosaccharide solution.Drying was taken out the pelletize thing after 50 minutes approximately in same device, crossed sieve No. 16, obtained the pelletize thing.
The same with embodiment 1～3, analyze the particle size distribution of this granule and estimated pelletize, the result shows: 45 μ m or be 25% or be lower than 25% that less than the ratio of the fine powder of 45 μ m pelletize is good.
Allow again 5 oral these granules of experimenter and in water, suspend after suspension, and to mouthfeel (harsh feeling, no aftertaste) estimated.During evaluation, the expression mouthfeel was very bad in 3 minutes, the expression mouthfeel was bad in 2 minutes, the expression mouthfeel was all right in 1 minute, the expression mouthfeel was good in 0 minute, and 5 experimenters' of statistics evaluation score is when average mark is 3 minutes or is lower than 3 fens and surpasses 2 timesharing usefulness * expressions, 2 minutes or be lower than 2 fens and surpass 1 timesharing and represent that with △ 1 minute～0 timesharing is represented with zero.
The result is displayed in Table 2.
[table 2]
| Embodiment 4 | ||
| Xylooligosaccharide (weight %) | 4.5 | |
| Tender leaf of Fructus Hordei Vulgaris powder (weight %) | 20.0 | |
| Angelica keiskei koidzumi powder (weight %) | 40.0 | |
| Matcha powder (weight %) | 10.0 | |
| Enzyme modification rutin (weight %) | 0.5 | |
| Maltose alcohol (weight %) | 25.0 | |
| Admittedly form subtotaling (weight %) | 100 | |
| Pelletize | ○ | |
| Mouthfeel is estimated | Shui Xuan Fu Time | ○ |
| The non-Xuan Fu of water Time | ○ | |
Evaluation result shows: the good mouthfeel of the granule that obtains among the embodiment 4.
The oral composition that the present invention relates to can be used as food, pharmaceuticals, and especially health food is assisted diet.Therefore, can in the industry in this field, utilize the present invention.
Claims (19)
1. the manufacture method of granular oral composition, it is for carrying out the method that granular oral composition is made in pelletize with oligosaccharide solution to Powdered per os raw material.
2. the manufacture method of oral composition according to claim 1, it is, oligosaccharide is dissolved in the spray liquid of fluidized bed comminution granulation, and, this per os raw material is carried out the method that oral composition is made in pelletize thereby make binding agent with oligosaccharide to Powdered per os raw material spraying.
3. the manufacture method of oral composition according to claim 1 and 2 is characterized in that, Powdered per os raw material is the raw material that contains water insoluble active ingredient.
4. the manufacture method of oral composition according to claim 3, wherein, the raw material that contains water insoluble active ingredient is to contain the dietary fiber raw material.
5. the manufacture method of oral composition according to claim 4, wherein, the raw material that contains water insoluble active ingredient is the green plants powder.
6. the manufacture method of oral composition according to claim 5, wherein, the green plants powder is one or more in angelica keiskei koidzumi powder, wheat tender leaf powder, green tea powder, the Brassica Oleracea var. acephala powder.
7. according to the manufacture method of any described oral composition of claim 1～6, wherein, comprise the operation that makes the preceding per os raw material of pelletize contain antioxidant content enzyme modification rutin.
8. according to the manufacture method of any described oral composition of claim 1～7, wherein, oligosaccharide is an xylooligosaccharide.
9. according to the manufacture method of any described oral composition of claim 1～8, it is characterized in that: oligosaccharide content is total solid 0.1～30 weight % that divides that forms in the oral composition.
10. according to the manufacture method of any described oral composition of claim 1～8, it is characterized in that: oligosaccharide content is total solid 1～20 weight % that divides that forms in the oral composition.
11. the manufacture method according to any described oral composition of claim 1～8 is characterized in that: oligosaccharide content is total solid 3～15 weight % that divide that form in the oral composition.
12. according to the manufacture method of any described oral composition of claim 1～11, wherein, oral composition be water or liquid, aqueous in the compositions that suspends.
13. according to the manufacture method of any described oral composition of claim 1～12, wherein, the binding agent beyond the oligosaccharide that is added is total solid 0～2 weight % that divides that forms.
14. oral composition, it is by any oral composition that described manufacture method obtains of claim 1～13.
15. oral composition according to claim 14, wherein, the fine powder that sieves by mesh 45 μ m accounts for 25 weight % or is lower than 25 weight %.
16. according to claim 13,14 or 15 described oral compositions, it is the oral composition of packing.
17. oral composition according to claim 16, it is to contain dietary fiber food.
18. oral composition according to claim 17 is characterized in that with the explanation about function.
19. oral composition according to claim 18, it is characterized in that, its function is: the symptom of preventing and improve arteriosclerosis, anemia, gastritis, gastric ulcer, constipation, improve liver function, suppress harmful substance absorption, improve intestinal environment, has fat-reducing effect, suppress cholesterol absorption, prevent that blood glucose value rises rapidly after meal, the activation superoxide dismutase, with the bacillus bifidus proliferation activity is the whole intestinal effect of representative, the prevention colorectal cancer promotes mineral to absorb, based on the function of antioxidation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP158628/2005 | 2005-05-31 | ||
| JP2005158628A JP2006335648A (en) | 2005-05-31 | 2005-05-31 | Method for producing granular oral composition with oligosaccharide solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1872342A true CN1872342A (en) | 2006-12-06 |
Family
ID=37481399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006100783280A Pending CN1872342A (en) | 2005-05-31 | 2006-05-11 | Process for preparation of granular oral composition using oligosaccharide solution |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2006335648A (en) |
| KR (1) | KR20080011389A (en) |
| CN (1) | CN1872342A (en) |
| TW (1) | TW200718434A (en) |
| WO (1) | WO2006129468A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105120878A (en) * | 2013-04-26 | 2015-12-02 | 三得利控股株式会社 | Composition comprising fructooligosaccharide and quercetin glycoside |
| CN117462602A (en) * | 2023-12-27 | 2024-01-30 | 深圳保时健生物工程有限公司 | Probiotic complexing agent and preparation method and application thereof |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4758974B2 (en) * | 2007-11-05 | 2011-08-31 | 旭化成ケミカルズ株式会社 | Acidic milk beverage |
| JP4600853B2 (en) * | 2007-12-21 | 2010-12-22 | 日本薬品開発株式会社 | Condensate-containing granule derived from young wheat leaves, granule and method for producing the same |
| JP5324943B2 (en) * | 2008-01-30 | 2013-10-23 | サントリーホールディングス株式会社 | Method for producing granular food composition by fluidized bed granulation |
| JP6910185B6 (en) * | 2017-04-13 | 2021-10-20 | 雄二 松川 | Parasympathetic-dominant lymphocyte-activating antitumor agent and its manufacturing method |
| JP6910200B6 (en) * | 2017-05-12 | 2021-10-20 | 雄二 松川 | Parasympathetic nerve predominance by absorption of upper gastrointestinal mucosa Lymphocyte activation Upper gastrointestinal mucosa absorption Antineoplastic agent |
| JP2019201629A (en) * | 2018-05-17 | 2019-11-28 | 大正製薬株式会社 | Solid material |
| KR102364023B1 (en) * | 2021-04-29 | 2022-02-17 | 주식회사 셀로닉스 | Method for producing granular formulation prebiotics using fructooligosaccharides without additives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3505367B2 (en) * | 1997-09-10 | 2004-03-08 | 三菱化学フーズ株式会社 | Sweetener composition |
| JP2000336354A (en) * | 1999-03-19 | 2000-12-05 | Sanei Gen Ffi Inc | Anti-fading agent |
| JP2002218945A (en) * | 2001-01-25 | 2002-08-06 | Toyo Shinyaku:Kk | Dietary fiber-containing food and method for forming the same and binder to be used for the method |
| JP2005124587A (en) * | 2001-12-28 | 2005-05-19 | Toyo Shinyaku:Kk | Granulated material of kale dry powder and method for producing the same |
| JP2005102639A (en) * | 2003-10-01 | 2005-04-21 | Marutomo Co Ltd | Constipation improving food and method for producing the same |
| JP2005295840A (en) * | 2004-04-08 | 2005-10-27 | Yoshio Minamitani | Healthy devil's tongue |
-
2005
- 2005-05-31 JP JP2005158628A patent/JP2006335648A/en not_active Withdrawn
-
2006
- 2006-05-11 CN CNA2006100783280A patent/CN1872342A/en active Pending
- 2006-05-15 WO PCT/JP2006/309628 patent/WO2006129468A1/en active Application Filing
- 2006-05-15 TW TW095117132A patent/TW200718434A/en unknown
- 2006-05-15 KR KR1020077026508A patent/KR20080011389A/en not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105120878A (en) * | 2013-04-26 | 2015-12-02 | 三得利控股株式会社 | Composition comprising fructooligosaccharide and quercetin glycoside |
| CN117462602A (en) * | 2023-12-27 | 2024-01-30 | 深圳保时健生物工程有限公司 | Probiotic complexing agent and preparation method and application thereof |
| CN117462602B (en) * | 2023-12-27 | 2024-03-29 | 深圳保时健生物工程有限公司 | Probiotic complexing agent and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| TW200718434A (en) | 2007-05-16 |
| KR20080011389A (en) | 2008-02-04 |
| WO2006129468A1 (en) | 2006-12-07 |
| JP2006335648A (en) | 2006-12-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1872342A (en) | Process for preparation of granular oral composition using oligosaccharide solution | |
| CN101341949B (en) | Various grains chewing slice and preparation method thereof | |
| Foo et al. | Transformation of durian biomass into a highly valuable end commodity: Trends and opportunities | |
| CN103005431B (en) | Seedless roxburgh rose-angelica keiskei composite chewable tablet and preparation method thereof | |
| CN107495355A (en) | A kind of fibrous type albumen meal replacement powder and preparation method thereof | |
| CN105120878A (en) | Composition comprising fructooligosaccharide and quercetin glycoside | |
| CN102342460A (en) | Selenium-enriched konjac rice and processing method thereof | |
| CN109619358A (en) | A kind of solid drinks and preparation method thereof based on soybean peptide albumen powder | |
| CN1929752B (en) | Process for producing health food containing dietary fiber | |
| CN107467468A (en) | Selenium-rich instant corn coarse cereals powder solid beverage and preparation method thereof | |
| CN106722455A (en) | calcium fruit chewable tablets and preparation method thereof | |
| CN103005259A (en) | Xylitol puerarin chewable tablet and preparation technique thereof | |
| CN108770977B (en) | Composite plant protein tablet candy and preparation method thereof | |
| CN100369557C (en) | Nutrition reinforcing rice and its production process | |
| CN108771061A (en) | Rocket ram jet concentration stock solution with anticancer function and preparation method thereof | |
| CN101396170A (en) | Modified absorbing material granules and preparation method and made cigarette composite tip | |
| CN1895282A (en) | Calcium supplementary agent and its preparation | |
| CN101032523B (en) | Royal jelly acid calcium and preparation process thereof | |
| CN106819678A (en) | Black fungus rich in selenium beverage and preparation method thereof | |
| CN102894089A (en) | Oat milk powder | |
| CN114668106A (en) | Folic acid and calcium compound anti-retrogradation recombinant rice and preparation method thereof | |
| CN101897437A (en) | Organic barley seedling powder chewable tablet and preparation method thereof | |
| CN1112184C (en) | Melatonin slow-releasing agent and its production process | |
| CN101589806A (en) | A kind of solid low-energy food that is rich in dietary fiber and polyethylene glycol and preparation method thereof | |
| CN1864544A (en) | Preparation method of health food substrate containing cow milk calcium powder and cow milk calcium tablet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: SUNTORY HOLDINGS CO., LTD. Free format text: FORMER OWNER: SUNTORY LTD. Effective date: 20090626 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20090626 Address after: Osaka Japan Applicant after: Suntory Holdings Limited Address before: Osaka Japan Applicant before: Suntory Ltd. |
|
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20061206 |