CN1870985B - Methods of treating cancer with HDAC inhibitors - Google Patents

Methods of treating cancer with HDAC inhibitors Download PDF

Info

Publication number
CN1870985B
CN1870985B CN2004800313068A CN200480031306A CN1870985B CN 1870985 B CN1870985 B CN 1870985B CN 2004800313068 A CN2004800313068 A CN 2004800313068A CN 200480031306 A CN200480031306 A CN 200480031306A CN 1870985 B CN1870985 B CN 1870985B
Authority
CN
China
Prior art keywords
saha
hdac inhibitor
day
amino
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2004800313068A
Other languages
Chinese (zh)
Other versions
CN1870985A (en
Inventor
N·G·巴科波洛斯
J·H·奇奥
T·A·米勒
C·M·帕拉迪塞
V·M·里奇翁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sloan Kettering Institute for Cancer Research
Merck HDAC Research LLC
Original Assignee
Sloan Kettering Institute for Cancer Research
Merck HDAC Research LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/650,025 priority Critical patent/US7148257B2/en
Priority to US10/650,025 priority
Priority to US10/665,079 priority
Priority to US10/665,079 priority patent/US20040127523A1/en
Application filed by Sloan Kettering Institute for Cancer Research, Merck HDAC Research LLC filed Critical Sloan Kettering Institute for Cancer Research
Priority to PCT/US2004/027943 priority patent/WO2005018578A2/en
Publication of CN1870985A publication Critical patent/CN1870985A/en
Application granted granted Critical
Publication of CN1870985B publication Critical patent/CN1870985B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links