CN1850079A - 一种微粉化马来酸多潘立酮药物组合物及其制备方法 - Google Patents
一种微粉化马来酸多潘立酮药物组合物及其制备方法 Download PDFInfo
- Publication number
- CN1850079A CN1850079A CN 200610038525 CN200610038525A CN1850079A CN 1850079 A CN1850079 A CN 1850079A CN 200610038525 CN200610038525 CN 200610038525 CN 200610038525 A CN200610038525 A CN 200610038525A CN 1850079 A CN1850079 A CN 1850079A
- Authority
- CN
- China
- Prior art keywords
- maleate
- compositions
- surfactant
- domperidone
- domperidone maleate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960004268 domperidone maleate Drugs 0.000 title claims abstract description 36
- OAUUYDZHCOULIO-BTJKTKAUSA-N domperidone maleate Chemical compound [O-]C(=O)\C=C/C([O-])=O.O=C1[NH2+]C2=CC=CC=C2N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2[NH2+]C1=O OAUUYDZHCOULIO-BTJKTKAUSA-N 0.000 title claims abstract description 36
- 239000000203 mixture Substances 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims description 11
- 239000000843 powder Substances 0.000 title claims description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 239000004094 surface-active agent Substances 0.000 claims description 17
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 9
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- 239000008101 lactose Substances 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 7
- 239000003085 diluting agent Substances 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical group O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 4
- 239000000741 silica gel Substances 0.000 claims description 4
- 229910002027 silica gel Inorganic materials 0.000 claims description 4
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 239000002994 raw material Substances 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 10
- 201000006549 dyspepsia Diseases 0.000 abstract description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 2
- 206010028817 Nausea and vomiting symptoms Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960001253 domperidone Drugs 0.000 description 12
- FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 description 12
- 238000000576 coating method Methods 0.000 description 11
- SDTHIDMOBRXVOQ-UHFFFAOYSA-N 5-[bis(2-chloroethyl)amino]-6-methyl-1h-pyrimidine-2,4-dione Chemical compound CC=1NC(=O)NC(=O)C=1N(CCCl)CCCl SDTHIDMOBRXVOQ-UHFFFAOYSA-N 0.000 description 8
- 229920003081 Povidone K 30 Polymers 0.000 description 8
- 150000002576 ketones Chemical class 0.000 description 8
- 239000011248 coating agent Substances 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- 229950008882 polysorbate Drugs 0.000 description 7
- 229920000136 polysorbate Polymers 0.000 description 7
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 6
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 6
- 239000011976 maleic acid Substances 0.000 description 6
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 6
- 238000004090 dissolution Methods 0.000 description 5
- 239000011812 mixed powder Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000007779 soft material Substances 0.000 description 5
- 239000000080 wetting agent Substances 0.000 description 5
- 230000002496 gastric effect Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000030136 gastric emptying Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 102000015554 Dopamine receptor Human genes 0.000 description 1
- 108050004812 Dopamine receptor Proteins 0.000 description 1
- 206010030216 Oesophagitis Diseases 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000006766 bile reflux Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000006881 esophagitis Diseases 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 210000003752 saphenous vein Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Images
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB200610038525XA CN100435795C (zh) | 2006-02-27 | 2006-02-27 | 一种微粉化马来酸多潘立酮药物组合物及其制备方法 |
Applications Claiming Priority (1)
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CNB200610038525XA CN100435795C (zh) | 2006-02-27 | 2006-02-27 | 一种微粉化马来酸多潘立酮药物组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN1850079A true CN1850079A (zh) | 2006-10-25 |
CN100435795C CN100435795C (zh) | 2008-11-26 |
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CNB200610038525XA Active CN100435795C (zh) | 2006-02-27 | 2006-02-27 | 一种微粉化马来酸多潘立酮药物组合物及其制备方法 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105267166A (zh) * | 2014-07-21 | 2016-01-27 | 常州制药厂有限公司 | 一种多潘立酮组合物的制备方法 |
CN115569121A (zh) * | 2022-09-08 | 2023-01-06 | 海南亚洲制药股份有限公司 | 一种多潘立酮片及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1449757A (zh) * | 2003-04-30 | 2003-10-22 | 江西省药物研究所 | 一种多潘立酮口崩片制剂及其制法 |
CN1528302A (zh) * | 2003-10-08 | 2004-09-15 | 南昌弘益科技有限公司 | 多潘立酮滴丸及其制备方法 |
-
2006
- 2006-02-27 CN CNB200610038525XA patent/CN100435795C/zh active Active
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105267166A (zh) * | 2014-07-21 | 2016-01-27 | 常州制药厂有限公司 | 一种多潘立酮组合物的制备方法 |
CN115569121A (zh) * | 2022-09-08 | 2023-01-06 | 海南亚洲制药股份有限公司 | 一种多潘立酮片及其制备方法 |
CN115569121B (zh) * | 2022-09-08 | 2024-01-23 | 海南亚洲制药股份有限公司 | 一种多潘立酮片及其制备方法 |
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Publication number | Publication date |
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CN100435795C (zh) | 2008-11-26 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: NANJING CHANG AO PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: CHANG'AO PHARMACY TECHNOLOGY CO., LTD., NANJING CITY Effective date: 20081031 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20081031 Address after: No. eight hundred, No. 2, Liuhe District, Jiangsu, Nanjing Patentee after: C & O Pharmaceutical Technology (Holdings) Ltd. Address before: Jiangsu Province, Nanjing Qinhuai District Colonel Field Road No. 30 Patentee before: Chang'ao Science and Technology of Medical Industry Co., Ltd., Nanjing |
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C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: Kexinlu Liuhe District of Nanjing City, Jiangsu Province, No. 63 211500 Patentee after: C & O Pharmaceutical Technology (Holdings) Ltd. Address before: 211500 No. eight hundred, No. 2, Liuhe District, Jiangsu, Nanjing Patentee before: C & O Pharmaceutical Technology (Holdings) Ltd. |
|
CP02 | Change in the address of a patent holder |
Address after: No. 63 Kexin Road, Jiangbei New District, Nanjing City, Jiangsu Province, 210000 Patentee after: C & O Pharmaceutical Technology (Holdings) Ltd. Address before: Kexinlu Liuhe District of Nanjing City, Jiangsu Province, No. 63 211500 Patentee before: C & O Pharmaceutical Technology (Holdings) Ltd. |
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CP02 | Change in the address of a patent holder |