CN1785292A - Medicine for treating flooding and spotting and its preparation method - Google Patents
Medicine for treating flooding and spotting and its preparation method Download PDFInfo
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Abstract
A Chinese medicine for treating uterine bleeding is prepared from 7 Chinese-medicinal materials including rehmannia root, rhubarb, sanguisorba root, notoginseng, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine for the treatment of metrorrhagia and preparation method thereof.
Background technology
Metrorrhagia belongs to the dysfunctional uterine hemorrhage category of modern medicine, being called for short anovulatory dysfunctional uterine hemorrhage, is a kind of common gynaecopathia, is meant unusual metrorrhagia, after indagation, find no whole body and genitals's organic disease, but because due to the neuroendocrine system functional disorder.Show as menstrual cycle irregular, through measure too much, menostaxis or irregular bleeding.According to whether ovulating, usually anovulatory dysfunctional uterine hemorrhage is divided into anovulation type and ovulation type two big classes, the former more sees, accounts for 80～90%, mainly occurs in adolescence and climacteric, the latter is more common in the period of duration women.Modern medicine is mainly following method to its treatment:
1. diagnostic curettage can be clarified a diagnosis to married woman's dilatation and curettage and also can be reached the hemostatic purpose.
2. gonadal hormone hemostasis (1) estrogen: be applicable to adolescence anovulatory dysfunctional uterine hemorrhage or serious anemia patient, should be according to its consumption that how much determines of amount of bleeding, available diethylstilbestrol or estradiol benzoate 2mg, every 6-8 hour is once, intramuscular injection, blood ends or blood volume obviously reduce after decrement gradually, per 3 days decrements once, every day decrement be no more than former consumption 1/3 the amount until maintenance dose, no matter use which kind of estrogen, should after two weeks of medication, add with progestogen such as medroxyprogestetone acetate 6-10mg, but drug withdrawal in 7 one 10 days.(2) progestogen: be applicable to no obvious anemia and climacteric anovulatory dysfunctional uterine hemorrhage patient, generally use Progesterone 20mg intramuscular injection, once a day, logotype 5 days, or medroxyprogestetone acetate 8-10mg, once a day, logotype 7-10 days.(3) androgen: normal and female, progestogen are used simultaneously.Testosterone propionate 25-50mg, once a day, intramuscular injection, 5 days.
3. hemorrhage: 6-aminocaprolc acid 1-2g, every day 4 times.
4. adjustment cycle: the artificial cycle is the sequential therapy of estrogen and progestogen, from the 5th day oral diethylstilbestrol 0.5-1mg of menstruation, serve on 30 days, and the intramuscular injection Progesterone was totally 5 days in last 5 days, and withdrawal bleeding is arranged after the drug withdrawal.
5. promoting ovulation drug: can choose wantonly following a kind of.(1) low dose of diethylstilbestrol cycle therapy: diethylstilbestrol 0.25-0.5mg, once a day, connecting 20 days is one-period.(2) CL (Clomiphene Citrate): 50-150mg was in menstruation logotype in the 5th day 5 days.(3) human chorionic gonadotropin (hCG): at present more than cycle 16-18 days, intramuscular injection 5000-10000IU.Simulation LH peak in mid-term, reaching and bringing out ovulation is purpose.
As seen modern medicine mainly adopts hormone therapy to the treatment of anovulatory dysfunctional uterine hemorrhage, and side effect is big, and recurrence easily.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of metrorrhagia and preparation method thereof, be used for holding metrorrhagia due to the stasis of blood under the arm because of heat in blood, side effect is little, is not easy recurrence, and stable curative effect is easy to use.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to metrorrhagia, with reference to the modern pharmacological research achievement, by traditional Chinese medical science prescription theory, skims the cream off milk, and makes its performance heat clearing and blood stasis dispersing, the effect of blood-arresting catamenia-regulating.
Medicine of the present invention comprises the crude drug of following component: (consumption is a weight portion)
35～55 parts of 10～25 portions of Radix Sanguisorbaes of 35～55 parts of Radix Et Rhizoma Rhei of Radix Rehmanniae
20～40 parts of 20～40 parts of Pollen Tyjphae (parched) of 10～25 portions of Radix Rubiaes of Radix Notoginseng.
In the above-mentioned raw materials medicine, also can add 4～8 parts of 20～40 parts of Endoconcha Sepiaes and/or GUANZHONGTAN.
Optimum weight part proportioning of medicine of the present invention is:
45 parts of 18 portions of Radix Sanguisorbaes of 45 parts of Radix Et Rhizoma Rhei of Radix Rehmanniae
30 parts of 30 parts of Pollen Tyjphae (parched) of 18 portions of Radix Rubiaes of Radix Notoginseng.
In the above-mentioned raw materials medicine, also can add 6 parts of 30 parts of Endoconcha Sepiaes and/or GUANZHONGTAN.
Above-mentioned each component is made medicine production method of the present invention is:
Get Radix Notoginseng half and/or GUANZHONGTAN, be ground into fine powder, standby; To remain half Radix Notoginseng and become coarse powder, mix, add 3～7 times of amounts of 80% ethanol with Radix Rehmanniae with the Radix Et Rhizoma Rhei pulverize separately, the heating and refluxing extraction secondary, each 0.5～2 hour, merge ethanol extract, filter filtrate for later use; Medicinal residues and Radix Sanguisorbae, Radix Rubiae, Pollen Typhae, and/or Endoconcha Sepiae adds 8～12 times of amounts of water, decoct three times, each 0.5～2 hour, collecting decoction, filter, filtrate decompression is condensed into that relative density surveys in the time of 60 ℃ be 1.10～1.15 clear paste, adds ethanol and make and contain pure content and reach 50%, stirs evenly, 5～10 ℃ of cold preservation 24 hours, get supernatant and above-mentioned alcohol extract and merge, decompression recycling ethanol, being condensed into that relative density surveys in the time of 60 ℃ is 1.25～1.30 clear paste, add Radix Notoginseng, and/or GUANZHONGTAN fine powder, mixing, drying is ground into fine powder, add starch in case of necessity, make granule, drying incapsulates.
Radix Et Rhizoma Rhei wherein: get clean Radix Et Rhizoma Rhei piece, steam method (appendix IID of Chinese Pharmacopoeia version in 2000) according to stewed with wine or wine and stew or steam and all become black to inside and outside.(see " one one the 18th～19 page of Chinese pharmacopoeia version in 2000)
Pollen Tyjphae (parched) wherein: get clean Pollen Typhae, fry to sepia according to parch to black method (appendix IID of Chinese Pharmacopoeia version in 2000).(see " one one the 290th～291 page of Chinese pharmacopoeia version in 2000)
Radix Rehmanniae heat clearing away, yin nourishing in the side, promote the production of body fluid, again can cooling blood for hemostasis, cure mainly heat at blood system, the absurd row of forcing blood, be the monarch drug of side; Radix Et Rhizoma Rhei clearing away heat and cooling blood hemostasis, blood stasis-eliminating and stagnation-dissipating is capable stagnates, the Radix Sanguisorbae cooling blood for hemostasis, and the puckery convergence has that removing heat from blood expels the heat-evil, the merit of astringing to arrest bleeding, and two medicines match, and helping monarch is minister; The Radix Rubiae cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling is usually used in various hemorrhage due to the heat in blood; The Pollen Tyjphae (parched) hemostasis with astringents, the promoting the circulation of blood blood stasis dispelling; Radix Notoginseng is warm in nature, has hemostasis not stay the length of the stasis of blood; The GUANZHONGTAN cooling blood for hemostasis, treatment metrorrhagia effect is good especially; The Endoconcha Sepiae astringing to arrest bleeding, the treatment metrostaxis is good at; Five medicines are shared, assist the monarch and his subjects, to strengthen the energy of hemostasis, blood stasis dispelling, removing heat from blood regulating menstruation, are adjuvant drug altogether.
In a word, we's eight flavors, monarch matches, the product of the thing of clearing away heat and cooling blood hemostasis and blood stasis dispelling, convergence mutually 5, Each performs its own functions, complements each other again.Full side pays attention to hemostasis and does not stay the stasis of blood, blood stasis dispelling and motionless blood, and the effect of playing heat clearing and blood stasis dispersing, blood-arresting catamenia-regulating altogether in order to the metrorrhagia due to the treatment heat in blood blood stasis, removes the clear stasis of blood of heat, and blood ends through transferring.
Advantage of the present invention is:
Along with the raising day by day of modernization of Chinese medicine degree, on the basis of herbal pharmacology and fitochemical studies, increasing middle pharmaceutically active ingredient or effective site are proved to be definite curative effect, prescription compatibility of medicines of the present invention is reasonable, technology advanced person, scientific and technical content height is modern herbal species.
For showing the therapeutic effect of medicine of the present invention to metrorrhagia, the present invention is through the clinical observation of 86 routine systems, and is as follows.
1, physical data
This proof scheme is selected patient's 115 examples altogether, and wherein 86 examples are organized in treatment, matched group 29 examples, and all case all meets inclusion criteria, does not have and withdraws from, rejects case.Treatment group and matched group ordinary circumstance are described below:
1.1, age distribution: 32.5 years old treatment group mean age, matched group 31.8 years old.
1.2, classification of diseases: by traditional Chinese medical science typing, treatment group heat in blood Phlegm-Heat Internal confusion Type patient 47 examples, stasis of blood uterus type patient 39 examples that stagnate; Matched group heat in blood Phlegm-Heat Internal confusion Type patient 17 examples, stasis of blood uterus type patient 12 examples that stagnate.By doctor trained in Western medicine classification, treatment group anovulation type patient 73 examples, ovulation type patient 13 examples; Matched group anovulation type patient 24 examples, ovulation type patient 5 examples.
1.3, the course of disease: the treatment group course of disease is the shortest to be first quarter moon, the longest 10 years, and average course of disease is 12.41 months; The matched group course of disease is the shortest to be first quarter moon, and the longest is 12 years, and average course of disease is 11.8 months.
1.4, severe extent: the treatment group is slight, moderate, severe patient are respectively 70 examples, 10 examples, 6 examples; Matched group is respectively 24 examples, 3 examples, 2 examples.Two groups of patient's physical data relatively see Table 1.Two groups of patients compare there was no significant difference aspect age, classification of diseases, the course of disease, degree, two groups of patients have comparability.
Table 1. Drug therapy metrorrhagia of the present invention patient physical data
| Medicine group of the present invention | The ZHIXUEBAO JIAONANG group | P | |
| Total example age several years (year) disease (example) blood-head Phlegm-Heat Internal confusion Type/stasis of blood uterus type that stagnates do not have the slightly (moderate of 200ml～the 500ml) (severe of 500ml～700ml) (700ml～1000ml) of the ovulation type/ovulation type course of disease (moon) degree (example) | 86 32.5±8.32 47/39 73/13 12.41±2.51 70 10 6 | 29 31.8±9.81 17/12 24/5 11.8±3.01 24 3 2 | ＞0.05 ＞0.05 ＞0.05 ＞0.05 ＞0.05 |
2, case is selected
2.1, diagnostic criteria
Related content is worked out in " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " of writing about content, " new Chinese medicine clinical research guideline " and the State Administration of Traditional Chinese Medicine of " metrorrhagia " with reference to " Gynecology of Chinese Medicine ".
2.1.1, the tcm diagnosis standard
(1) the menses no periodic can follow
(2) through amount or down sudden and violent as notes, or persistent vaginal bloody discharge, or both alternately occur.
(3) palpus and vaginal bleeding during pregnancy, ectopic pregnancy, postpartum hemorrhage, leucorrhea with bloody discharge and lump in the abdomen, the vaginal hemorrhage that wound causes is differentiated mutually.
2.1.2, Chinese medical discrimination
(1) disturb in the heat in blood: many through blood volume, or dripping unclean, color depth is red or purplish red, and the matter pine is thick, accompanies a small amount of clot.The flushed complexion dizziness, irritated disgruntled, xerostomia happiness drink, constipation dark coloured urine.Red tongue, yellow fur, wiry and frequent pulse or sliding number.
(2) the stagnant uterus of the stasis of blood: menometrorrhagia is dripping without cease, or suddenly cruelly down, color is dark or black, accompanies stasis of blood piece, lower abdomen pain, alleviation of pain under the piece.There is ecchymosis on purplish tongue or limit, deep and hesitant pulse or stringy and tense pulse.
2.1.3, the Western medicine diagnose standard
(1) anovulatory anovulatory dysfunctional uterine hemorrhage
Because ovulation failure, no corpus luteum forms, and endometrial hyperplasia is long, the irregular metrorrhagia of clinical manifestation, and menstrual period are different in size, and are few for a long time during amount of bleeding, even bleed profusely.Gynecologial examination: cervix uteri hyperemia, softer when hemorrhage, palace mouth pine, the uterus is also softer, sometimes with a side or the increase of bilateral ovaries capsule.Basal body temperature unipolar type, vagina break away from the cell smear anovulatory cycle and sexually revise, and cervix uteri mucus presented fernlike crystal in hemorrhage preceding 1～2 day, and the visible proliferative phase of inner membrance pathologic finding changes or Swiss cheese hyperplasia, and the no secretory phase changes.
(2) ovulation property anovulatory dysfunctional uterine hemorrhage
1. luteal insufficiency: through preceding endometrial secretion dysfunction; The clinical manifestation menstrual cycle shortens, and how much differs menostaxis through amount; The visible sometimes keratinocyte index of vaginal smear is higher, and cell accumulation, gauffer are not good; The basal body temperature biphasic or bipolar type, shorten luteal phase, below 10 days, or is trapezoidal rising or decline.
2. atrophy of corpus iuteum is incomplete: intrauterine film biopsy in the 5th day menstrual period is the secretory phase change; Clinical manifestation is that menstrual cycle is normal, and how many menostaxis differs through amount; Basal body temperature is the biphasic or bipolar type that is not true to type, fall delay or decline gradually.
2.2 case inclusion criteria
2.2.1, include the case standard in
All classical symptoms with metrorrhagia, the diagnosis and the corresponding Chinese medical discrimination standard person that meet the doctor trained in Western medicine dysfunctional uterine bleeding can include the test case in.
2.2.2, get rid of the case standard
(1) patient age is below 14 years old or more than 50 years old.
(2) gestation or women breast-feeding their children, allergic constitution or to this medicine allergy.
(3) be associated with serious primary disease such as cardiovascular, liver, kidney, psychotic etc. affect the treatment or safety judgement person.
(4) metrorrhagia confirms by gestation, tumor on inspection, goes up causers such as ring, wound or systemic bleeding disease.
3, therapeutic scheme
The patient in 3: 1 ratios, is randomized into treatment group and matched group.
3.1, the treatment group: light, the oral medicine of the present invention of moderate patient, 4/time, three times on the one; Severe patient cooperates uterine curettage, 4/time of oral medicines of the present invention, three times on the one.
3.2, matched group: light, moderate patient's Orally taken hemostatic health-care capsule (production of Qishan, Shaanxi pharmaceutical factory), 5/time, three times on the one; Severe patient cooperates uterine curettage, 5/time of Orally taken hemostatic health-care capsules, three times on the one.
3.3 the course of treatment: 2 weeks.
4, curative effect determinate standard
4.1, recovery from illness: after the control over bleeding, continuous 3 menstrual cycle, menstrual period, blood volume are all normal, and subjective symptoms disappears, and hemoglobin can be recovered normal ovulation more than 100g/L, be no less than 12 days luteal phase, or climacteric women blood only after menopause person.
4.2, produce effects: after the control over bleeding, menstrual cycle, blood volume are normal substantially, but still grow (more than 7 days, below 10 days) menstrual period, and subjective symptoms disappears substantially, and hemoglobin is more than 100g/L.
4.3, effectively: menstrual cycle, menstrual period, part subjective symptoms be improved significantly, oligemia, hemoglobin is the above person of 80g/L.
4.4, invalid: above every improvement of all not having.
5, result
5.1, content of hemoglobin and examination of basal body temperature before and after two groups of patient treatments
All carry out content of hemoglobin and examination of basal body temperature before and after two groups of patient treatments, treatment anemia patient 47 examples before the treatment, average content of hemoglobin is 73g/L, the average hemoglobin in treatment back returns to 109g/L; Anemia patient 15 examples before the treatment of control group, average content of hemoglobin 76g/L, the average hemoglobin in treatment back returns to 101g/L.Treatment group examination of basal body temperature is two-phase person's 13 examples before the treatment, is two-phase person's 67 examples after the treatment; The matched group examination of basal body temperature is two-phase person's 5 examples before the treatment, is two-phase person's 13 examples after the treatment.Show that from above data medicine of the present invention can obviously recover patient's ovulation function and content of hemoglobin.
Content of hemoglobin and examination of basal body temperature before and after table 2. treatment
| The treatment group | Matched group | |||
| Before the treatment | After the treatment | Before the treatment | After the treatment | |
| Hemoglobin (g/L) basal body temperature (two-phase example number) | 73±1.21 13 | 109±0.93 67 | 76±0.89 5 | 101±1.03 13 |
5.2, two groups of patient's clinical efficacies relatively
Medicine of the present invention and ZHIXUEBAO JIAONANG contrast, the result is as shown in table 3 for treatment metrorrhagia clinical efficacy.Medicine group total effective rate of the present invention is 90.69%, and the ZHIXUEBAO JIAONANG group is 82.76%.Learn check by statistics, two groups of curative effects have significant difference, illustrate that medicine of the present invention is better than ZHIXUEBAO JIAONANG to the curative effect of heat in blood Phlegm-Heat Internal confusion Type and the stagnant uterus type metrorrhagia of the stasis of blood.
Table 3. medicine of the present invention and ZHIXUEBAO JIAONANG contrast treatment metrorrhagia clinical efficacy
| The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate (%) | |
| Treatment group matched group | 86 29 | 59 13 | 12 8 | 7 3 | 8 5 | 90.69* 82.76 |
Annotate: * and matched group be P＜0.05 relatively
5.3, untoward reaction
Do not see adverse effect in the 86 routine patient treatment processes, patient liver, renal function do not have obvious change.
6, conclusion
115 routine metrorrhagia patients are observed in this clinical verification altogether, Drug therapy metrorrhagia total effective rate 90.69% of the present invention, and ZHIXUEBAO JIAONANG treatment metrorrhagia total effective rate 82.76%.Show that Drug therapy metrorrhagia of the present invention is evident in efficacy, do not see any untoward reaction in the therapeutic process, and taking convenience, so be worth clinical expansion.
Specific embodiment
Embodiment 1
By following weight weighting raw materials (unit: gram)
Radix Rehmanniae 45 Radix Et Rhizoma Rhei 18 Radix Sanguisorbaes 45 Radix Notoginseng 18
Radix Rubiae 30 Pollen Tyjphae (parched) 30.
Preparation method: above crude drug, half is ground into fine powder to get Radix Notoginseng, and is standby; To remain half Radix Notoginseng and become coarse powder, mix, add 3～7 times of amounts of 80% ethanol with Radix Rehmanniae with the Radix Et Rhizoma Rhei pulverize separately, the heating and refluxing extraction secondary, each 0.5～2 hour, merge ethanol extract, filter filtrate for later use; Medicinal residues and Radix Sanguisorbae, Endoconcha Sepiae, Radix Rubiae, Pollen Typhae add 8～12 times of amounts of water, decoct three times, each 0.5～2 hour, collecting decoction, filter, filtrate decompression is condensed into that relative density surveys in the time of 60 ℃ be 1.10～1.15 clear paste, adds ethanol and make and contain pure content and reach 50%, stirs evenly, 5～10 ℃ of cold preservation 24 hours, get supernatant and above-mentioned alcohol extract and merge, decompression recycling ethanol, being condensed into that relative density surveys in the time of 60 ℃ is 1.25～1.30 clear paste, add the Radix Notoginseng fine powder, mixing, drying is ground into fine powder, add starch in case of necessity, make granule, drying incapsulates.
Embodiment 2
By following weight weighting raw materials (unit: gram)
Radix Rehmanniae 35 Radix Et Rhizoma Rhei 10 Radix Sanguisorbaes 35 Radix Notoginseng 10
Radix Rubiae 20 Pollen Tyjphae (parched) 20.
Preparation method: with embodiment 1
Embodiment 3
By following weight weighting raw materials (unit: gram)
Radix Rehmanniae 55 Radix Et Rhizoma Rhei 25 Radix Sanguisorbaes 55 Radix Notoginseng 25
Radix Rubiae 40 Pollen Tyjphae (parched) 40.
Preparation method: with embodiment 1
Embodiment 4
By following weight weighting raw materials (unit: gram)
Radix Rehmanniae 40 Radix Et Rhizoma Rhei 15 Radix Sanguisorbaes 40 Radix Notoginseng 12
Radix Rubiae 35 Pollen Tyjphae (parched) 35 Endoconcha Sepiaes 20.
Preparation method: above crude drug, half is ground into fine powder to get Radix Notoginseng, and is standby; To remain half Radix Notoginseng and become coarse powder, mix, add 3～7 times of amounts of 80% ethanol with Radix Rehmanniae with the Radix Et Rhizoma Rhei pulverize separately, the heating and refluxing extraction secondary, each 0.5～2 hour, merge ethanol extract, filter filtrate for later use; Medicinal residues and Radix Sanguisorbae, Radix Rubiae, Pollen Typhae and Endoconcha Sepiae add 8～12 times of amounts of water, decoct three times, each 0.5～2 hour, collecting decoction, filter, filtrate decompression is condensed into that relative density surveys in the time of 60 ℃ be 1.10～1.15 clear paste, adds ethanol and make and contain pure content and reach 50%, stirs evenly, 5～10 ℃ of cold preservation 24 hours, get supernatant and above-mentioned alcohol extract and merge, decompression recycling ethanol, being condensed into that relative density surveys in the time of 60 ℃ is 1.25～1.30 clear paste, add the Radix Notoginseng fine powder, mixing, drying is ground into fine powder, add starch in case of necessity, make granule, drying incapsulates.
Embodiment 5
By following weight weighting raw materials (unit: gram)
Radix Rehmanniae 50 Radix Et Rhizoma Rhei 20 Radix Sanguisorbaes 50 Radix Notoginseng 20
Radix Rubiae 35 Pollen Tyjphae (parched) 35 GUANZHONGTAN 8.
Preparation method: above crude drug, get Radix Notoginseng one half-sum GUANZHONGTAN, be ground into fine powder, standby; To remain half Radix Notoginseng and become coarse powder, mix, add 3～7 times of amounts of 80% ethanol with Radix Rehmanniae with the Radix Et Rhizoma Rhei pulverize separately, the heating and refluxing extraction secondary, each 0.5～2 hour, merge ethanol extract, filter filtrate for later use; Medicinal residues and Radix Sanguisorbae, Radix Rubiae, Pollen Typhae add 8～12 times of amounts of water, decoct three times, each 0.5～2 hour, collecting decoction, filter, filtrate decompression is condensed into that relative density surveys in the time of 60 ℃ be 1.10～1.15 clear paste, adds ethanol and make and contain pure content and reach 50%, stirs evenly, 5～10 ℃ of cold preservation 24 hours, get supernatant and above-mentioned alcohol extract and merge, decompression recycling ethanol, being condensed into that relative density surveys in the time of 60 ℃ is 1.25～1.30 clear paste, add Radix Notoginseng and GUANZHONGTAN fine powder, mixing, drying is ground into fine powder, add starch in case of necessity, make granule, drying incapsulates.
Embodiment 6
By following weight weighting raw materials (unit: gram)
Radix Rehmanniae 38 Radix Et Rhizoma Rhei 12 Radix Sanguisorbaes 38 Radix Notoginseng 12
Radix Rubiae 35 Pollen Tyjphae (parched) 25 GUANZHONGTAN 4.
Preparation method: above crude drug, get Radix Notoginseng one half-sum GUANZHONGTAN and be ground into fine powder, standby; To remain half Radix Notoginseng and become coarse powder, mix, add 3～7 times of amounts of 80% ethanol with Radix Rehmanniae with the Radix Et Rhizoma Rhei pulverize separately, the heating and refluxing extraction secondary, each 0.5～2 hour, merge ethanol extract, filter filtrate for later use; Medicinal residues and Radix Sanguisorbae, Radix Rubiae, Pollen Typhae add 8～12 times of amounts of water, decoct three times, each 0.5～2 hour, collecting decoction, filter, filtrate decompression is condensed into that relative density surveys in the time of 60 ℃ be 1.10～1.15 clear paste, adds ethanol and make and contain pure content and reach 50%, stirs evenly, 5～10 ℃ of cold preservation 24 hours, get supernatant and above-mentioned alcohol extract and merge, decompression recycling ethanol, being condensed into that relative density surveys in the time of 60 ℃ is 1.25～1.30 clear paste, add Radix Notoginseng and GUANZHONGTAN fine powder, mixing, drying is ground into fine powder, add starch in case of necessity, make granule, drying incapsulates.
Embodiment 7
By following weight weighting raw materials (unit: gram)
Radix Rehmanniae 50 Radix Et Rhizoma Rhei 20 Radix Sanguisorbaes 50 Radix Notoginseng 20
Radix Rubiae 35 Pollen Tyjphae (parched) 35 Endoconcha Sepiaes 40.
Preparation method: above crude drug, half is ground into fine powder to get Radix Notoginseng, and is standby; To remain half Radix Notoginseng and become coarse powder, mix, add 3～7 times of weights of 80% ethanol with Radix Rehmanniae with the Radix Et Rhizoma Rhei pulverize separately, the heating and refluxing extraction secondary, each 0.5～2 hour, merge ethanol extract, filter filtrate for later use; Medicinal residues and Radix Sanguisorbae, Radix Rubiae, Pollen Typhae and Endoconcha Sepiae add 8～12 times of amounts of water, decoct three times, each 0.5～2 hour, collecting decoction, filter, filtrate decompression is condensed into that relative density surveys in the time of 60 ℃ be 1.10～1.15 clear paste, adds ethanol and make and contain pure content and reach 50%, stirs evenly, 5～10 ℃ of cold preservation 24 hours, get supernatant and above-mentioned alcohol extract and merge, decompression recycling ethanol, being condensed into that relative density surveys in the time of 60 ℃ is 1.25～1.30 clear paste, add the Radix Notoginseng fine powder, mixing, drying is ground into fine powder, add starch in case of necessity, make granule, drying incapsulates.
Embodiment 8
By following weight weighting raw materials (unit: gram)
Radix Rehmanniae 42 Radix Et Rhizoma Rhei 20 Radix Sanguisorbaes 40 Radix Notoginseng 20
Radix Rubiae 30 Pollen Tyjphae (parched) 30 GUANZHONGTAN 5 Endoconcha Sepiaes 35.
Preparation method: above crude drug, get Radix Notoginseng one half-sum GUANZHONGTAN, be ground into fine powder, standby; To remain half Radix Notoginseng and become coarse powder, mix, add 3～7 times of amounts of 80% ethanol with Radix Rehmanniae with the Radix Et Rhizoma Rhei pulverize separately, the heating and refluxing extraction secondary, each 0.5～2 hour, merge ethanol extract, filter filtrate for later use; Medicinal residues and Radix Sanguisorbae, Radix Rubiae, Pollen Typhae and Endoconcha Sepiae add 8～12 times of amounts of water, decoct three times, each 0.5～2 hour, collecting decoction, filter, filtrate decompression is condensed into that relative density surveys in the time of 60 ℃ be 1.10～1.15 clear paste, adds ethanol and make and contain pure content and reach 50%, stirs evenly, 5～10 ℃ of cold preservation 24 hours, get supernatant and above-mentioned alcohol extract and merge, decompression recycling ethanol, being condensed into that relative density surveys in the time of 60 ℃ is 1.25～1.30 clear paste, add Radix Notoginseng and GUANZHONGTAN fine powder, mixing, drying is ground into fine powder, add starch in case of necessity, make granule, drying incapsulates.
Embodiment 9
By following weight weighting raw materials (unit: gram)
Radix Rehmanniae 45 Radix Et Rhizoma Rhei 18 Radix Sanguisorbaes 45 Radix Notoginseng 18
Radix Rubiae 30 Pollen Tyjphae (parched) 30 GUANZHONGTAN 6 Endoconcha Sepiaes 30.
Preparation method: above crude drug, get Radix Notoginseng one half-sum GUANZHONGTAN, be ground into fine powder, standby; To remain half Radix Notoginseng and become coarse powder, mix, add 3～7 times of amounts of 80% ethanol with Radix Rehmanniae with the Radix Et Rhizoma Rhei pulverize separately, the heating and refluxing extraction secondary, each 0.5～2 hour, merge ethanol extract, filter filtrate for later use; Medicinal residues and Radix Sanguisorbae, Radix Rubiae, Pollen Typhae add 8～12 times of amounts of water, decoct three times, each 0.5～2 hour, collecting decoction, filter, filtrate decompression is condensed into that relative density surveys in the time of 60 ℃ be 1.10～1.15 clear paste, adds ethanol and make and contain pure content and reach 50%, stirs evenly, 5～10 ℃ of cold preservation 24 hours, get supernatant and above-mentioned alcohol extract and merge, decompression recycling ethanol, being condensed into that relative density surveys in the time of 60 ℃ is 1.25～1.30 clear paste, add Radix Notoginseng and GUANZHONGTAN fine powder, mixing, drying is ground into fine powder, add starch in case of necessity, make granule, drying incapsulates.
Embodiment 10
By following weight weighting raw materials (unit: gram)
Radix Rehmanniae 45 Radix Et Rhizoma Rhei 18 Radix Sanguisorbaes 45 Radix Notoginseng 18
Radix Rubiae 30 Pollen Tyjphae (parched) 30 GUANZHONGTAN 6.
Preparation method: above crude drug, get Radix Notoginseng one half-sum GUANZHONGTAN, be ground into fine powder, standby; To remain half Radix Notoginseng and become coarse powder, mix, add 3～7 times of amounts of 80% ethanol with Radix Rehmanniae with the Radix Et Rhizoma Rhei pulverize separately, the heating and refluxing extraction secondary, each 0.5～2 hour, merge ethanol extract, filter filtrate for later use; Medicinal residues and Radix Sanguisorbae, Radix Rubiae, Pollen Typhae add 8～12 times of amounts of water, decoct three times, each 0.5～2 hour, collecting decoction, filter, filtrate decompression is condensed into that relative density surveys in the time of 60 ℃ be 1.10～1.15 clear paste, adds ethanol and make and contain pure content and reach 50%, stirs evenly, 5～10 ℃ of cold preservation 24 hours, get supernatant and above-mentioned alcohol extract and merge, decompression recycling ethanol, being condensed into that relative density surveys in the time of 60 ℃ is 1.25～1.30 clear paste, add Radix Notoginseng and GUANZHONGTAN fine powder, mixing, drying is ground into fine powder, add starch in case of necessity, make granule, drying incapsulates.
Embodiment 11
By following weight weighting raw materials (unit: gram)
Radix Rehmanniae 45 Radix Et Rhizoma Rhei 18 Radix Sanguisorbaes 45 Radix Notoginseng 18
Radix Rubiae 30 Pollen Tyjphae (parched) 30 Endoconcha Sepiaes 30.
Preparation method: above crude drug, half is ground into fine powder to get Radix Notoginseng, and is standby; To remain half Radix Notoginseng and become coarse powder, mix, add 3～7 times of amounts of 80% ethanol with Radix Rehmanniae with the Radix Et Rhizoma Rhei pulverize separately, the heating and refluxing extraction secondary, each 0.5～2 hour, merge ethanol extract, filter filtrate for later use; Medicinal residues and Radix Sanguisorbae, Radix Rubiae, Pollen Typhae and Endoconcha Sepiae add 8～12 times of amounts of water, decoct three times, each 0.5～2 hour, collecting decoction, filter, filtrate decompression is condensed into that relative density surveys in the time of 60 ℃ be 1.10～1.15 clear paste, adds ethanol and make and contain pure content and reach 50%, stirs evenly, 5～10 ℃ of cold preservation 24 hours, get supernatant and above-mentioned alcohol extract and merge, decompression recycling ethanol, being condensed into that relative density surveys in the time of 60 ℃ is 1.25～1.30 clear paste, add the Radix Notoginseng fine powder, mixing, drying is ground into fine powder, add starch in case of necessity, make granule, drying incapsulates.
Claims (5)
1, a kind of medicine for the treatment of metrorrhagia is characterized in that comprising following bulk drugs:
35～55 parts of 10～25 portions of Radix Sanguisorbaes of 35～55 parts of Radix Et Rhizoma Rhei of Radix Rehmanniae
20～40 parts of 20～40 parts of Pollen Tyjphae (parched) of 10～25 portions of Radix Rubiaes of Radix Notoginseng.
2, the medicine of treatment metrorrhagia as claimed in claim 1 is characterized in that adding 4～8 parts of 20～40 parts of Endoconcha Sepiaes and/or GUANZHONGTAN in described raw material.
3, the medicine of treatment metrorrhagia as claimed in claim 1 is characterized in that comprising following bulk drugs:
45 parts of 18 portions of Radix Sanguisorbaes of 45 parts of Radix Et Rhizoma Rhei of Radix Rehmanniae
30 parts of 30 parts of Pollen Tyjphae (parched) of 18 portions of Radix Rubiaes of Radix Notoginseng.
4, the medicine of treatment metrorrhagia as claimed in claim 2 is characterized in that adding 6 parts of 30 parts of Endoconcha Sepiaes and/or GUANZHONGTAN in described raw material.
5, the preparation method as medicine as described in the claim 1,2,3 or 4 is:
Get Radix Notoginseng half and/or GUANZHONGTAN, be ground into fine powder, standby; To remain half Radix Notoginseng and become coarse powder, mix, add 3～7 times of amounts of 80% ethanol with Radix Rehmanniae with the Radix Et Rhizoma Rhei pulverize separately, the heating and refluxing extraction secondary, each 0.5～2 hour, merge ethanol extract, filter filtrate for later use; Medicinal residues and Radix Sanguisorbae, Radix Rubiae, Pollen Typhae, and/or Endoconcha Sepiae adds 8～12 times of amounts of water, decoct three times, each 0.5～2 hour, collecting decoction, filter, filtrate decompression is condensed into that relative density surveys in the time of 60 ℃ be 1.10～1.15 clear paste, adds ethanol and make and contain pure content and reach 50%, stirs evenly, 5～10 ℃ of cold preservation 24 hours, get supernatant and above-mentioned alcohol extract and merge, decompression recycling ethanol, being condensed into that relative density surveys in the time of 60 ℃ is 1.25～1.30 clear paste, add Radix Notoginseng, and/or GUANZHONGTAN fine powder, mixing, drying is ground into fine powder, add starch in case of necessity, make granule, drying incapsulates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100963611A CN100394936C (en) | 2005-11-17 | 2005-11-17 | Medicine for treating flooding and spotting and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100963611A CN100394936C (en) | 2005-11-17 | 2005-11-17 | Medicine for treating flooding and spotting and its preparation method |
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| Publication Number | Publication Date |
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| CN1785292A true CN1785292A (en) | 2006-06-14 |
| CN100394936C CN100394936C (en) | 2008-06-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100963611A Ceased CN100394936C (en) | 2005-11-17 | 2005-11-17 | Medicine for treating flooding and spotting and its preparation method |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101810798A (en) * | 2010-05-26 | 2010-08-25 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating metrorrhagia and metrostaxis and preparation method thereof |
| CN101757309B (en) * | 2009-10-16 | 2011-12-28 | 西安千禾药业有限责任公司 | Medicament for treating uterine bleeding and preparation process thereof |
| CN102327401A (en) * | 2011-09-23 | 2012-01-25 | 江西普正制药有限公司 | Method for preparing medicament for treating uterine bleeding |
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| CN1058184C (en) * | 1997-12-30 | 2000-11-08 | 宋振家 | Gynaecologist's hemostatic |
| CN1319429A (en) * | 2001-03-05 | 2001-10-31 | 韩继祥 | Medicine for treating female metrorrhagia and metrostaxis and preparation method thereof |
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| CN101757309B (en) * | 2009-10-16 | 2011-12-28 | 西安千禾药业有限责任公司 | Medicament for treating uterine bleeding and preparation process thereof |
| CN101810798A (en) * | 2010-05-26 | 2010-08-25 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating metrorrhagia and metrostaxis and preparation method thereof |
| CN102327401A (en) * | 2011-09-23 | 2012-01-25 | 江西普正制药有限公司 | Method for preparing medicament for treating uterine bleeding |
| CN103007211A (en) * | 2012-11-20 | 2013-04-03 | 山西医科大学 | Traditional Chinese medicine preparation for treating primary vaginal dripping |
| CN103007211B (en) * | 2012-11-20 | 2015-06-03 | 山西医科大学 | Traditional Chinese medicine preparation for treating primary metrostaxis |
| CN104547317A (en) * | 2013-10-16 | 2015-04-29 | 西安千禾药业有限责任公司 | Preparation method of pharmaceutical composition Xueping for treating metrorrhagia and metrostaxis |
| CN104547317B (en) * | 2013-10-16 | 2018-09-21 | 西安千禾药业有限责任公司 | A kind of preparation method that pharmaceutical composition blood that treating uterine bleeding is flat |
| CN105412335A (en) * | 2014-09-17 | 2016-03-23 | 李丹 | Medicine for treating uterine bleeding |
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| CN100394936C (en) | 2008-06-18 |
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Address after: High tech Zone Zhang Bayi Road 710065 Shaanxi city of Xi'an province No. 1 Huixin IBC-B block 11 layer Patentee after: Xian Qianhe Pharmaceutical Co., Ltd. Address before: 710075 Shaanxi city of Xi'an province high tech Industrial Development Zone, high tech Road No. 52 building 17 layer Patentee before: Xian Qianhe Pharmaceutical Co., Ltd. |
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