CN1748681A - Oxibendazole nasal jelly for treating adenoid hypertrophy - Google Patents

Oxibendazole nasal jelly for treating adenoid hypertrophy Download PDF

Info

Publication number
CN1748681A
CN1748681A CN 200410078455 CN200410078455A CN1748681A CN 1748681 A CN1748681 A CN 1748681A CN 200410078455 CN200410078455 CN 200410078455 CN 200410078455 A CN200410078455 A CN 200410078455A CN 1748681 A CN1748681 A CN 1748681A
Authority
CN
China
Prior art keywords
oxibendazole
nasal
jelly
add
general
Prior art date
Application number
CN 200410078455
Other languages
Chinese (zh)
Inventor
王鹤尧
郑文婕
Original Assignee
王鹤尧
郑文婕
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 王鹤尧, 郑文婕 filed Critical 王鹤尧
Priority to CN 200410078455 priority Critical patent/CN1748681A/en
Publication of CN1748681A publication Critical patent/CN1748681A/en

Links

Abstract

The present invention relates to the preparation process of nasal oxibendazole jelly and the application of the nasal oxibendazole jelly in treating adenoid hypertrophy.

Description

The Oxibendazole nasal jelly of treatment adenoid vegetation

The present invention relates to use oxibendazole to prepare nasal gel, and treat adenoid vegetation with the nasal gel of oxibendazole.

Adenoid vegetation (adenoidal hypertrophy) is the pharyngeal tonsil hypertrophy.Child's adenoid vegetation often belongs to physiological, and nasopharynx part has lymphoid tissue during baby due, and with the age hypertrophy, reach in the time of 6 years old at utmost, degenerate gradually later on, if it influences whole body health or adjacent organs person, just claim adenoid vegetation.

One, the cause of disease Childhood is easily suffered from acute rhinitis, acute tonsillitis and influenza etc., if outbreak repeatedly, gland sample body is the hypertrophy hypertrophy rapidly, cause and increase the weight of nasal obstruction, hinder the nasal cavity drain, rhinitis and nasosinusitis secretions stimulates gland sample body to make it to continue hypertrophy again, forms the vicious cycle of reciprocal causation.Be more common in the child, normal and chronic tonsillitis merges and exists.

Two, clinical manifestation

(1) local symptom: the child stops up choana and pharyngeal opening of auditory tube because of adenoid vegetation, and symptoms such as ear nasopharynx can take place.Mouth breathing when showing as sleep, weighing down behind the root of the tongue often has the sound of snoring, and it is not peaceful to sleep night, and the nose secretion is many, when speaking closed rhinolalia is arranged, and voice are ambiguous.Because of long-term mouth breathing, cause the facial bone dysplasia, upper jaw bone is elongated, high-arched palate, denture is not whole, and last incisor exposes, and lip is thick, and the facial expression that lacks has dull-witted performance, forms " adenoid face ".The coordinate movement imbalance is often choked and is coughed between swallowing and breathing.The dirty stimulation respiratory mucosa of secretions is easily suffered from tracheitis.Because of being obstructed, pharyngotympanic tube causes that easily non-suppurative otitis media causes suction and goes down otopiesis.

(2) General Symptoms: nutrition of whole body and dysplasia are often arranged, mainly show as chronic poisoning reflexive nervous symptoms, as the expansion of the uneasiness blunt, uncomfortable in chest of expressing one's feelings, lung is bad, with the passing of time causes pigeon chest or flat chest.Minority is because the resistance of chronic nose, long term hypoxia and pulmonary heart disease occurs, even acute heart failure.Adenoid face is seen in inspection, and hard palate is high, and there is pink on the visible nasopharynx of posterior rhinoscopy top and narrow, and lobulated lymphoid tissue piece, nasopharynx part palpation can touch soft lump, can make X line nasopharynx lateral projection in case of necessity, help diagnosis.

Three, treatment present situation

Excision gland sample body can excise simultaneously when operation on tonsils, or carry out separately, should not can consider X-ray therapy by operator.

Four, oxibendazole brief introduction

Oxibendazole, english common name: Oxibendazole; Generic name: oxibendazole, Oxibendazole, Oxibendazole, Equitac, Loditac, Oxibendazolum; Chemical name: 5-propoxyl group-benzimidazolyl-2 radicals-methyl carbamate.Be broad-spectrum de-worming medicine.Can influence the multiple biochemical metabolism approach of polypide.Ascarid, ancylostome and whipworm all there is obvious anthelmintic action.Drive the ancylostome medicine relatively with other, this product also has better curative effect not only to the Ancylostoma duodenale good effect to American hookworm.The worm's ovum negative conversion rate of 2 days and therapy on the 3rd can reach 56%-100%.General anthelmintic is to the whipworm weak curative effect, and is though the worm's ovum negative conversion rate can reach 70% when oxantel drives whipworm, invalid to ancylostome and ascarid; And this product is not only effective to ancylostome and ascarid, and the curative effect of driving whipworm also can reach about 70%.。

Five, so far, all do not see any report or document record that oxibendazole is used for the treatment of adenoid vegetation both at home and abroad as yet.

The present invention is made into compound recipe with oxibendazole as independent effective ingredient or with other medicines, makes nasal gel.

The indication of the nasal gel made from oxibendazole or with the compound recipe that contains oxibendazole of the present invention includes, but are not limited to following disease: adenoid vegetation, nasal polyp or nasal polyp, rhinitis, pharyngitis, tracheitis and bronchitis.

Use of the present inventionly with oxibendazole or the nasal gel made with the compound recipe that contains oxibendazole, for the adenoid vegetation patient, directly nasal-cavity administration can make loose gland sample body dwindle effectively, can alleviate relevant symptom.

Nasal gel of the present invention, for nasal spray one in, mean in nasal spray to add the adjuvant that can increase medicinal liquid viscosity, medicinal liquid can be adhered on the nasal mucosa better, thereby made medicine can be from medicinal liquid slowly or continue to discharge.The described adjuvant that can increase medicinal liquid viscosity, include, but are not limited to: the hypromellose of hydroxyethyl-cellulose, all size or the type of hydroxy methocel, all size or the type of card pool general (Carbopol), all size or the type of all size or type etc.

Adenoid vegetation of the present invention is that those skilled in the art is known, has it to define accurately in the modern medical book.Its pathological change as previously mentioned.Rhinitis of the present invention, pharyngitis, tracheitis and bronchitis also are that the ordinary artisan of this area is known, have it to define accurately in the modern medical book.

By following examples to the preparation of Oxibendazole nasal jelly of the present invention, be described with application of its treatment adenoid vegetation.

It should be noted that, following embodiment just is used for explanation and unrestricted the present invention, well-known to those skilled in the artly by other administration route oxibendazole is used for the treatment of nasal polyp or nasal polyp, rhinitis, pharyngitis, tracheitis and bronchitic technology all within the scope of the invention.

Embodiment 1 adopts the general preparation Oxibendazole nasal jelly of card pool

Take by weighing card pool general 940 (Carbopol940) 2g; Get the sterile distilled water of about 80 ℃ of 100ml; It is general to add the card pool while stirring in hot water, after whole adding card pools are general, continues stirring 12h.After treating that temperature reduces, add the 30mg oxibendazole, add an amount of antiseptic again, behind the restir 30min, and the oxibendazole gel, divide to install in the nasal mist bottle or in the nasal drop bottle, promptly get Oxibendazole nasal jelly.

Embodiment 2 adopts hydroxy methocel to prepare Oxibendazole nasal jelly

Take by weighing hydroxy methocel 2g; Get the sterile distilled water of about 80 ℃ of 100ml; It is general to add the card pool while stirring in hot water, after whole adding card pools are general, continues stirring 12h.After treating that temperature reduces, add the 30mg oxibendazole, add an amount of antiseptic again, behind the restir 30min, and the oxibendazole gel, divide to install in the nasal mist bottle or in the nasal drop bottle, promptly get Oxibendazole nasal jelly.

Embodiment 3 adopts hydroxyethyl-cellulose to prepare Oxibendazole nasal jelly

Take by weighing hydroxyethyl-cellulose 2g; Get the sterile distilled water of about 80 ℃ of 100ml; It is general to add the card pool while stirring in hot water, after whole adding card pools are general, continues stirring, 12h.After treating that temperature reduces, add the 30mg oxibendazole, add an amount of antiseptic again, behind the restir 30min, and the oxibendazole gel, divide to install in the nasal mist bottle or in the nasal drop bottle, promptly get Oxibendazole nasal jelly.

Embodiment 4 adopts hypromellose to prepare Oxibendazole nasal jelly

Take by weighing hypromellose 2g; Get the sterile distilled water of about 80 ℃ of 100ml; It is general to add the card pool while stirring in hot water, after whole adding card pools are general, continues stirring 12h.After treating that temperature reduces, add the 30mg oxibendazole, add an amount of antiseptic again, behind the restir 30min, and the oxibendazole gel, divide to install in the nasal mist bottle or in the nasal drop bottle, promptly get Oxibendazole nasal jelly.

Embodiment 5 uses Oxibendazole nasal jelly treatment adenoid vegetation

Since childhood, the man, 6 years old, sleep had the sound of snoring, is diagnosed as adenoid vegetation, intended excision gland sample body.Its father and mother adversary's art has doubt, uses Oxibendazole nasal jelly, and every day, nasal-cavity administration was 2 times, and after 20 days, the sound of snoring disappears, and to hospital's further consultation, gland sample body obviously dwindles.

Embodiment 6 uses Oxibendazole nasal jelly treatment adenoid vegetation

Since childhood, man, 8 years old, upper respiratory tract infection is often arranged, and the nasal mucus secretion is many, and sleep has the sound of snoring, be diagnosed as adenoid vegetation, use Oxibendazole nasal jelly, every day, nasal-cavity administration was 2 times, after 20 days, the sound of snoring disappears, and voice are obviously clear before treating, and the nasal mucus secretion also obviously reduces, to hospital's further consultation, gland sample body obviously dwindles.

Claims (2)

1. the nasal gel that oxibendazole is made as one of effective ingredient or effective ingredient.
2. the application of oxibendazole in the production of the nasal gel that is used for the treatment of adenoid vegetation.
CN 200410078455 2004-09-14 2004-09-14 Oxibendazole nasal jelly for treating adenoid hypertrophy CN1748681A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 200410078455 CN1748681A (en) 2004-09-14 2004-09-14 Oxibendazole nasal jelly for treating adenoid hypertrophy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 200410078455 CN1748681A (en) 2004-09-14 2004-09-14 Oxibendazole nasal jelly for treating adenoid hypertrophy

Publications (1)

Publication Number Publication Date
CN1748681A true CN1748681A (en) 2006-03-22

Family

ID=36604460

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 200410078455 CN1748681A (en) 2004-09-14 2004-09-14 Oxibendazole nasal jelly for treating adenoid hypertrophy

Country Status (1)

Country Link
CN (1) CN1748681A (en)

Similar Documents

Publication Publication Date Title
Berlin Behcet's syndrome with involvement of the central nervous system: report of a case, with necropsy, of lesions of the mouth, genitalia and eyes; review of the literature
Ballenger et al. Diseases of the nose, throat, and ear
Kirtaniya et al. Marsupialization: a conservative approach for treating dentigerous cyst in children in the mixed dentition
Bachmann et al. Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease
ES2263643T3 (en) Use of hydroxyethyrutosids for the treatment of symptoms of the common chilled rh, of hay fever and of infections related to respiratory touch.
McGowan et al. Pressure in the common bile duct of man: its relation to pain following cholecystectomy
Billings Chronic focal infections and their etiologic relations to arthritis and nephritis
Brown The Surgery of Oral Diseases and Malformations: Their Diagnosis and Treatment
Ballenger Diseases of the nose, throat and ear: medical and surgical
Chimenos Küstner et al. Lepromatous leprosy: a review and case report
Anura Traumatic oral mucosal lesions: a mini review and clinical update
CN103610871B (en) A kind of Chinese medicine composition for the treatment of periodontitis
Saini et al. Dental expression and role in palliative treatment
ES2660494T3 (en) Use of levocetirizine and montelukast in the treatment of a traumatic injury
KR101801864B1 (en) Use of levocetirizine and montelukast in the treatment of influenza, common cold and inflammation
Ireland A dictionary of dentistry
Odell Clinical Problem Solving in Dentistry (Indian Reprint)
Dinwiddie Congenital upper airway obstruction
CN104013846A (en) Traditional Chinese medicine composition for treating dental ulcer and application thereof
Koichiro Preventing aspiration pneumonia by oral health care
Yamamoto et al. The application of a night guard for sleep-related xerostomia
Moore Principles of oral surgery
Agius Long-term follow-up of patients with facial pain in chronic rhinosinusitis--correlation with nasal endoscopy and CT.
WO2019098621A1 (en) Lip sealing tape
Reznick et al. Cervicofacial subcutaneous air emphysema after dental extraction

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20070302

Address after: No. 12, Huayuan Road, Jiangsu, Nanjing

Applicant after: Jiangsu Simcere Pharmaceutical Research Company Limited

Address before: 5C, building six, 6 District, far road, century garden, Beijing, Haidian District

Applicant before: Wang Heyao

Co-applicant before: Zheng Wenjie

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication