CN1724552A - Preparation method of astilbin - Google Patents
Preparation method of astilbin Download PDFInfo
- Publication number
- CN1724552A CN1724552A CN200510040944.2A CN200510040944A CN1724552A CN 1724552 A CN1724552 A CN 1724552A CN 200510040944 A CN200510040944 A CN 200510040944A CN 1724552 A CN1724552 A CN 1724552A
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- CN
- China
- Prior art keywords
- astilbin
- preparation
- ethanol
- weight
- recrystallization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- ZROGCCBNZBKLEL-FHXNIQKESA-N Astilbin Natural products O([C@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c(c(O)cc(O)c2)C1=O)[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O1 ZROGCCBNZBKLEL-FHXNIQKESA-N 0.000 title claims abstract description 57
- ZROGCCBNZBKLEL-MPRHSVQHSA-N astilbin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1C(=O)C2=C(O)C=C(O)C=C2O[C@@H]1C1=CC=C(O)C(O)=C1 ZROGCCBNZBKLEL-MPRHSVQHSA-N 0.000 title claims abstract description 57
- 238000002360 preparation method Methods 0.000 title claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 92
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000000284 extract Substances 0.000 claims abstract description 25
- 239000000463 material Substances 0.000 claims abstract description 24
- 238000001556 precipitation Methods 0.000 claims abstract description 18
- 238000000605 extraction Methods 0.000 claims abstract description 17
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920005989 resin Polymers 0.000 claims abstract description 11
- 239000011347 resin Substances 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000004952 Polyamide Substances 0.000 claims abstract description 9
- 229920002647 polyamide Polymers 0.000 claims abstract description 9
- 238000005238 degreasing Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 239000003208 petroleum Substances 0.000 claims abstract description 6
- 238000001953 recrystallisation Methods 0.000 claims description 19
- 239000002904 solvent Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 239000003463 adsorbent Substances 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 8
- 230000001476 alcoholic effect Effects 0.000 claims description 8
- 239000012452 mother liquor Substances 0.000 claims description 8
- 241001002544 Engelhardia Species 0.000 claims description 7
- 239000003960 organic solvent Substances 0.000 claims description 6
- 238000010298 pulverizing process Methods 0.000 claims description 6
- 238000003810 ethyl acetate extraction Methods 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 150000001408 amides Chemical class 0.000 claims description 2
- 239000012043 crude product Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 239000007864 aqueous solution Substances 0.000 abstract description 3
- 238000000151 deposition Methods 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 235000019439 ethyl acetate Nutrition 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 description 34
- 239000000243 solution Substances 0.000 description 25
- 239000000469 ethanolic extract Substances 0.000 description 10
- 238000004090 dissolution Methods 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 238000012869 ethanol precipitation Methods 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 241001092376 Astilbe Species 0.000 description 2
- 235000003205 Smilax rotundifolia Nutrition 0.000 description 2
- 240000009022 Smilax rotundifolia Species 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- 102000016912 Aldehyde Reductase Human genes 0.000 description 1
- 108010053754 Aldehyde reductase Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 206010039361 Sacroiliitis Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 206010053613 Type IV hypersensitivity reaction Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 239000002024 ethyl acetate extract Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- -1 flavonoid compound Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 238000000247 postprecipitation Methods 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 238000013094 purity test Methods 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000005951 type IV hypersensitivity Effects 0.000 description 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100409442A CN100348606C (en) | 2005-07-08 | 2005-07-08 | Preparation method of astilbin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100409442A CN100348606C (en) | 2005-07-08 | 2005-07-08 | Preparation method of astilbin |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1724552A true CN1724552A (en) | 2006-01-25 |
CN100348606C CN100348606C (en) | 2007-11-14 |
Family
ID=35924195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005100409442A Expired - Fee Related CN100348606C (en) | 2005-07-08 | 2005-07-08 | Preparation method of astilbin |
Country Status (1)
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CN (1) | CN100348606C (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100348610C (en) * | 2005-09-01 | 2007-11-14 | 桂林莱茵生物科技股份有限公司 | Method for extracting astilbin from engelhardtia leaves |
CN101935332A (en) * | 2010-07-16 | 2011-01-05 | 沈阳药科大学 | Preparation method and application of 5,7,4'-trihydroxyl8-methoxyl-3-O-alpha-L-rhamnoside and active composition thereof |
CN101972287A (en) * | 2010-10-18 | 2011-02-16 | 山东大学威海分校 | Preparation method of Chinese astilbe extract and purpose thereof |
CN102020690A (en) * | 2010-11-09 | 2011-04-20 | 苏州派腾生物医药科技有限公司 | Preparation method of astilbin |
CN102432652A (en) * | 2010-09-29 | 2012-05-02 | 苏州瑞蓝博中药技术开发有限公司 | Method for extracting astilbin from china root |
CN103012522A (en) * | 2012-12-28 | 2013-04-03 | 顾玲 | Purification process of astilbin |
CN103768082A (en) * | 2012-10-18 | 2014-05-07 | 滨州医学院 | Application of astilbin to preparation of medicament for treating or preventing diabetes accompanied with stroke |
CN105061531A (en) * | 2015-07-29 | 2015-11-18 | 成都大学 | Astilbe chinensis glycoside derivatives and preparation method thereof |
CN106565804A (en) * | 2016-10-10 | 2017-04-19 | 广西来宾绿翔生物科技有限公司 | Extraction technology of Engelhardia roxburghiana Wall leaf astilbin |
CN107056858A (en) * | 2017-04-28 | 2017-08-18 | 南宁馨艺荣生物科技有限公司 | Process for extracting astilbin from engelhardtia leaves |
CN107951923A (en) * | 2017-12-07 | 2018-04-24 | 广西壮族自治区中医药研究院 | A kind of preparation method of astragalus leaf flavonoids and its application in protection blood vessel drug eluting is prepared |
CN109369749A (en) * | 2018-11-30 | 2019-02-22 | 陕西嘉禾生物科技股份有限公司 | A kind of preparation method of Astilbin |
CN111437302A (en) * | 2015-05-25 | 2020-07-24 | 蔡世珍 | Application of extract of engelhardtia leaves after water extraction and macroporous resin treatment in preparation of diabetes drugs and analysis method thereof |
CN111440221A (en) * | 2019-12-13 | 2020-07-24 | 湖南甜蔓生物科技有限公司 | Astilbin prepared from Engelhardtia chrysolepis Hance leaf and its preparation method |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101982183A (en) * | 2010-10-18 | 2011-03-02 | 山东大学威海分校 | Preparation method of Astilbe chinensis root extract and antioxidant application of Astilbe chinensis root extract |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3226700B2 (en) * | 1994-02-07 | 2001-11-05 | 丸善製薬株式会社 | Whitening agent and skin external preparation |
CN1279052C (en) * | 2004-03-11 | 2006-10-11 | 南开大学 | Process for extracting total flavone and total oside of astragalus from astragalus |
-
2005
- 2005-07-08 CN CNB2005100409442A patent/CN100348606C/en not_active Expired - Fee Related
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100348610C (en) * | 2005-09-01 | 2007-11-14 | 桂林莱茵生物科技股份有限公司 | Method for extracting astilbin from engelhardtia leaves |
CN101935332A (en) * | 2010-07-16 | 2011-01-05 | 沈阳药科大学 | Preparation method and application of 5,7,4'-trihydroxyl8-methoxyl-3-O-alpha-L-rhamnoside and active composition thereof |
CN101935332B (en) * | 2010-07-16 | 2014-06-25 | 沈阳药科大学 | Preparation method and application of 5,7,4'-trihydroxyl8-methoxyl-3-O-alpha-L-rhamnoside and active composition thereof |
CN102432652A (en) * | 2010-09-29 | 2012-05-02 | 苏州瑞蓝博中药技术开发有限公司 | Method for extracting astilbin from china root |
CN101972287A (en) * | 2010-10-18 | 2011-02-16 | 山东大学威海分校 | Preparation method of Chinese astilbe extract and purpose thereof |
CN102020690A (en) * | 2010-11-09 | 2011-04-20 | 苏州派腾生物医药科技有限公司 | Preparation method of astilbin |
CN103768082B (en) * | 2012-10-18 | 2016-06-15 | 滨州医学院 | Astilbin merges the application in apoplexy medicine in preparation treatment or prevention diabetes |
CN103768082A (en) * | 2012-10-18 | 2014-05-07 | 滨州医学院 | Application of astilbin to preparation of medicament for treating or preventing diabetes accompanied with stroke |
CN103012522A (en) * | 2012-12-28 | 2013-04-03 | 顾玲 | Purification process of astilbin |
CN103012522B (en) * | 2012-12-28 | 2015-03-25 | 顾玲 | Purification process of astilbin |
CN111437302A (en) * | 2015-05-25 | 2020-07-24 | 蔡世珍 | Application of extract of engelhardtia leaves after water extraction and macroporous resin treatment in preparation of diabetes drugs and analysis method thereof |
CN111437302B (en) * | 2015-05-25 | 2022-03-01 | 苏州优诺康医药科技有限公司 | Application of extract of engelhardtia leaves after water extraction and macroporous resin treatment in preparation of diabetes drugs and analysis method thereof |
CN105061531A (en) * | 2015-07-29 | 2015-11-18 | 成都大学 | Astilbe chinensis glycoside derivatives and preparation method thereof |
CN106565804A (en) * | 2016-10-10 | 2017-04-19 | 广西来宾绿翔生物科技有限公司 | Extraction technology of Engelhardia roxburghiana Wall leaf astilbin |
CN107056858A (en) * | 2017-04-28 | 2017-08-18 | 南宁馨艺荣生物科技有限公司 | Process for extracting astilbin from engelhardtia leaves |
CN107951923A (en) * | 2017-12-07 | 2018-04-24 | 广西壮族自治区中医药研究院 | A kind of preparation method of astragalus leaf flavonoids and its application in protection blood vessel drug eluting is prepared |
CN109369749A (en) * | 2018-11-30 | 2019-02-22 | 陕西嘉禾生物科技股份有限公司 | A kind of preparation method of Astilbin |
CN109369749B (en) * | 2018-11-30 | 2021-10-01 | 陕西嘉禾生物科技股份有限公司 | Preparation method of astilbin |
CN111440221A (en) * | 2019-12-13 | 2020-07-24 | 湖南甜蔓生物科技有限公司 | Astilbin prepared from Engelhardtia chrysolepis Hance leaf and its preparation method |
CN111440221B (en) * | 2019-12-13 | 2021-11-26 | 湖南甜蔓生物科技有限公司 | Astilbin prepared from Engelhardtia chrysolepis Hance leaf and its preparation method |
Also Published As
Publication number | Publication date |
---|---|
CN100348606C (en) | 2007-11-14 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: JIANGSU ZHENGDA TIANQING PHARMACEUTICALS INDUSTRY |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20100420 Address after: 210093 Life Science Institute, 22 Hankou Road, Jiangsu, Nanjing Co-patentee after: Jiangsu Chiatai Tianqing Pharmaceutical Co., Ltd. Patentee after: Nanjing University Address before: 210093 Life Science Institute, 22 Hankou Road, Jiangsu, Nanjing Patentee before: Nanjing University |
|
C56 | Change in the name or address of the patentee |
Owner name: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: JIANGSU ZHENGDA TIANQING PHARMACEUTICAL CO., LTD. |
|
CP01 | Change in the name or title of a patent holder |
Address after: 222006 Sinpo City, Lianyungang Province, North Road, No. 8, No. Patentee after: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Patentee after: Nanjing University Address before: 222006 Sinpo City, Lianyungang Province, North Road, No. 8, No. Patentee before: Jiangsu Chiatai Tianqing Pharmaceutical Co., Ltd. Patentee before: Nanjing University |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20071114 Termination date: 20180708 |
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CF01 | Termination of patent right due to non-payment of annual fee |