CN1698754A - Medicine for treating acute and chronic pancreatitis - Google Patents

Abstract

The invention relates to a medicine for treating acute and chronic pancreatitis which comprises the following raw materials (by weight portions), scaly anteater 40-60 parts, Indian quassiawood 30-50 parts, fructus aurantii 100-200 parts, green chiretta 200-400 parts, lysimachia christinae 100-300 parts, coptis root 200-400 parts, red peony root 50-150 parts, bupleurum root 50-150 parts, corydalis ambigua 50-150 parts.

Description

The medicine of treatment acute and chronic pancreatitis

Technical field

The present invention relates to a kind of medicine for the treatment of acute and chronic pancreatitis.

Background technology

At present, because the pancreatitis patient that multiple factor causes is a lot, Therapeutic Method roughly has three kinds at present: one, go on a diet; Two, antibiotic therapy; Three, suppress glandular secretion.Going on a diet to alleviate gastrointestinal stress, but gastrointestinal can not be cured because of going on a diet because of the not enough dysfunction that occurs of pancreatic secretion.Antibiotic therapy can prevent secondary infection.But pancreatitic pathogenic factor is not due to the antibacterial, so therapeutic value targetedly not.Suppress the medicine of glandular secretion, the pancreatic secretion amount is alleviated, but also suppressed other glandular secretion simultaneously, and quicken with xerostomia, platycoria, perspiration, heart rate, also secretion inhibitor can not make pancreatic secretion unimpeded, so be not direct Therapeutic Method.

The pathogeny of acute and chronic pancreatitis is: be obstructed because of retention of damp-heat in the interior makes pancreatic secretion, pancreatic juice backflows, and digests due to the autologous tissue.The treatment pancreatitis of current the world of medicine does not also have a kind of medicine for the treatment of targetedly.Really will reach the treatment pancreatitis, have a kind of pancreatic secretion that can make unimpeded, pancreatic juice can be gone into the medicine that enteric cavity participates in digestion smoothly.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of acute and chronic pancreatitis, this medicine basis practical proof for many years at pancreatitic pathogeny, is taken this medicine and can be made pancreatic secretion unimpeded, make pancreatic juice can go into enteric cavity smoothly and participate in digestion, thereby reach the effect of the logical pancreas of silt heat clearing away of dispelling.

The medicine of treatment acute and chronic pancreatitis is characterized in that it being to be made by the following raw material medicaments in part by weight proportioning: Squama Manis 40-60 part, Ramulus Et Folium Picrasmae 30-50 part, Fructus Aurantii 100-200 part, Herba Andrographis 200-400 part, Herba Lysimachiae 100-300 part, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) 200-400 part, Radix Paeoniae Rubra 50-150 part, Radix Bupleuri 50-150 part, Rhizoma Corydalis 50-150 part.

Its preparation method is: getting Squama Manis by above-mentioned weight portion proportioning, to wear into 100 order fine powders standby, and other gets each medicine and decocts with water secondary, filters, and merges and cut liquid, is condensed into thick paste, add the Squama Manis powder, mixing is made wet grain with 16 mesh sieves, and drying is sieved, granulate adds an amount of excipient, tabletting, every heavy 0.5g.

Function cures mainly: abdominal distention anorexia, bitter taste due to the heat-clearing and toxic substances removing, the logical pancreas that becomes silted up of dispelling, treatment acute and chronic pancreatitis, epigastrium pain, dyspepsia.

Usage and dosage: one time 6, three times on the one are oral.

Taboo: it is greasy to avoid eating anything raw or cold, alcohol prohibition, the careful clothes of anemia of pregnant woman.

Advantage of the present invention is the blank that this medicine has been filled up present this field treatment pancreatitis disease, and this medicine adopts Tabules, makes things convenient for patient's medication, need not inject or the Chinese medicine decoction.This medicine can make pancreatic secretion unimpeded at pancreatitic pathogeny, makes pancreatic juice can go into enteric cavity smoothly and participates in digestion, thereby reach the effect of the logical pancreas of silt heat clearing away of dispelling.

The specific embodiment

Embodiment 1:

The medicine of treatment acute and chronic pancreatitis is to be made by the following raw material medicaments in part by weight proportioning: Squama Manis 60g, Ramulus Et Folium Picrasmae 40g, Fructus Aurantii 150g, Herba Andrographis 300g, Herba Lysimachiae 200g, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) 300g, Radix Paeoniae Rubra 100g, Radix Bupleuri 100g, Rhizoma Corydalis 100g.

Its preparation method is: getting Squama Manis 60g, to wear into 100 order fine powders standby, and other gets each medicine and decocts with water secondary, filters, merge and cut liquid, be condensed into thick paste, add the Squama Manis powder, mixing is made wet grain with 16 mesh sieves, drying is sieved, granulate, add an amount of excipient, tabletting becomes 600 clear sheets of pancreas, every heavy 0.5g.

Embodiment 2:

The medicine of treatment acute and chronic pancreatitis is to be made by the following raw material medicaments in part by weight proportioning: 40 parts of Squama Manis, 30 parts of Ramulus Et Folium Picrasmaes, 100 parts of Fructus Aurantii, 200 parts of Herba Andrographis, 300 parts of Herba Lysimachiaes, 400 parts of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori)s, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Bupleuri, 150 parts of Rhizoma Corydalis.

Its preparation method is with embodiment 1.

Embodiment 3:

The medicine of treatment acute and chronic pancreatitis is characterized in that it being to be made by the following raw material medicaments in part by weight proportioning: 50 parts of Squama Manis, 50 parts of Ramulus Et Folium Picrasmaes, 200 parts of Fructus Aurantii, 400 parts of Herba Andrographis, 100 parts of Herba Lysimachiaes, 200 parts of Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori)s, 150 parts of Radix Paeoniae Rubra, 150 parts of Radix Bupleuri, 50 parts of Rhizoma Corydalis.

Its preparation method is with embodiment 1.

The clinical observation material of medicine of the present invention

1, physical data

Accept out-patient's 100 many cases for medical treatment, wherein male 70 examples, women 30 examples.Age 20-30 year 5 examples, 31-40 year 38 examples, 41-50 year 42 examples, 15 examples more than 50 years old.

2, diagnostic criteria

The diagnostic criteria of chronic pancreatitis:

1) clear and definite pancreatitic histodiagnosis is arranged;

2) clear and definite calcification of pancreas is arranged;

3) typical chronic pancreatitis symptom and sign is arranged, typical chronic pancreatitis iconography features such as tangible exocrine pancreas obstacle and ERCP is arranged, except pancreas adenocarcinoma;

4) ultrasonic endoscope has typical chronic pancreatitis iconography feature.

The diagnostic criteria of acute pancreatitis:

1) patient of light disease has violent and epigastrium pain that continue, feels sick, vomiting, slight heating, epigastrium tenderness, but does not have tension of abdominal muscle, have simultaneously serum amylase and (or) amylase in urine significantly raises, and gets rid of other acute abdomen persons, promptly can diagnose.

Serious symptom is removed possesses patient with slight symptoms's diagnostic criteria, and have local complication (pancreatic necrosis, pseudocyst, abscess) and (or) organ failure.

3, Therapeutic Method

The clear sheet of pancreas, 6, days three times oral.

Curative effect determinate standard:

Produce effects: stomachache, abdominal distention is felt sick, and vomiting disappears substantially, abdominal tenderness, rebound tenderness, muscle tonus disappearance, ultrasound diagnosis show that the ductus pancreaticus expansion disappears, and body of pancreas increases disappearance, and the pancreas peripheral edema disappears.

Take a turn for the better: stomachache, abdominal distention, feel sick, vomiting alleviates, abdominal tenderness, rebound tenderness, muscle tonus alleviates, ultrasound diagnosis shows that the ductus pancreaticus expansion alleviates, body of pancreas increases and alleviates, the pancreas peripheral edema alleviates.

Invalid: stomachache, abdominal distention, nauseating, vomiting no change, abdominal tenderness, rebound tenderness, muscle tonus no change, ultrasound diagnosis no change.

5, therapeutic outcome

State the clinical efficacy table as follows:

Treatment time (week)	Produce effects		Take a turn for the better		Invalid		Effective percentage %
								The example number	Obvious effective rate (%)	The example number	Improvement rate (%)	The example number	Inefficiency (%)
	??1	??0	??0	??65	??65	??35								??35	??65
??2							??40	??40	??58	??58	??10	??10	??90
	??3	??65	??65	??26	??26	??9								??9	??91
??4							??85	??85	??7	??7	??8	??8	??92
	??5	??88	??88	??5	??5	??7								??7	??93

In a word, in the treatment time in 5 weeks, with tablet in treatment patient's 100 examples of the present invention, produce effects 88 examples as a result, 5 examples that take a turn for the better, invalid 7 examples, obvious effective rate 88%, improvement rate 5%, total effective rate 93%.

The case of choosing two routine typicality below further specifies curative effect of the present invention:

Case history one:

Li Qingdian, man, 42 years old, consultation time JIUYUE in 1998 16 days.

Epigastrium pain, anorexia, abdominal distention three days.

The eating and drinking too much at one meal history is arranged, previously healthy.

Have a medical check-up: refreshing clear, handsome, breast corridor symmetry, two pulmonary respiration sounds are clear, and heart does not have noise, and rule is whole, and abdomen is soft, epigastrium tenderness (+), extremity are movable normal, and nervous system, physiological reflex exist, and pathologic reflex is not drawn.The traditional Chinese medical science is checked: red tongue, yellow and greasy fur, slippery and rapid pulse.

Lab testing, amylase in urine 600 units, blood amylase 150 units.

The B ultrasonic prompting, pancreas echo is unusual, the body of gland enlargement.

Diagnosis: acute pancreatitis

The rule of treatment: heat-clearing and toxic substances removing, change the logical pancreas of silt

The clear sheet of pancreas, 6 day three times is oral

The back further consultation of one week, the abdominal distention bitter taste alleviates, and appetite strengthens, and idol has epigastrium dull pain.

Clothes recovery from illness in 15 days continues in the top.

Case two: Wang Ping, woman, 26 years old

The main suit, abdominal distention was suffered from abdominal pain about one month.

Before one month because of emotion influence, abdominal distention appearred, epigastrium pain, and untreated increases the weight of gradually, loss of appetite, bitter taste, times of defecation increases, and it is not good enough to sleep.

Previously healthy.

It is refreshing clear to have a medical check-up, and two pulmonary respiration are clear, and heart circle is little, and hear sounds is pure, and rule is whole, and abdomen is soft, no tenderness, and neurologic check is no abnormal.The traditional Chinese medical science is checked: red tongue, yellow and greasy fur, rapid pulse.

Lab testing: liver function, routine blood test are normal, amylase in urine 300 units, and blood amylase is normal.

B ultrasonic prompting: pancreas blur margin, density anomaly.

Diagnosis: chronic pancreatitis

Treatment: the clear sheet of pancreas, 5 day three times is oral.

Further consultation behind the first quarter moon, all diseases alleviate, and the clothes medicine-feeding two weeks that continues is checked amylase in urine 205 units, and ultrasound diagnosis pancreas echogenic density takes a turn for the better, and advises it to continue to take medicine until recovery from illness.

Claims (1)

1, the medicine of treatment acute and chronic pancreatitis is characterized in that it being to be made by the following raw material medicaments in part by weight proportioning: Squama Manis 40-60 part, Ramulus Et Folium Picrasmae 30-50 part, Fructus Aurantii 100-200 part, Herba Andrographis 200-400 part, Herba Lysimachiae 100-300 part, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) 200-400 part, Radix Paeoniae Rubra 50-150 part, Radix Bupleuri 50-150 part, Rhizoma Corydalis 50-150 part;

Its preparation method is: getting Squama Manis by above-mentioned weight portion proportioning, to wear into 100 order fine powders standby, and other gets each medicine and decocts with water secondary, filters, and merges and cut liquid, is condensed into thick paste, add the Squama Manis powder, mixing is made wet grain with 16 mesh sieves, and drying is sieved, granulate adds an amount of excipient, tabletting, every heavy 0.5g.