CN1583164A - Preparing procedure of transfer factor for intravenous injection - Google Patents
Preparing procedure of transfer factor for intravenous injection Download PDFInfo
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- CN1583164A CN1583164A CNA2004100464040A CN200410046404A CN1583164A CN 1583164 A CN1583164 A CN 1583164A CN A2004100464040 A CNA2004100464040 A CN A2004100464040A CN 200410046404 A CN200410046404 A CN 200410046404A CN 1583164 A CN1583164 A CN 1583164A
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- China
- Prior art keywords
- transfer factor
- injection
- intravenous injection
- xylitol
- sodium chloride
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
A process for preparing the transfer factor used for the high-dosage intravenous injection features that the solution of sodium chloride or glucose or xylitol is proportionally mixing with the raw liquid of transfer factor.
Description
The present invention relates to a kind of preparation technology's flow process of a kind of biological preparation-used for intravenous injection transfer factor.Especially can be different from the various various types of agents dosage forms of the already present transfer factor in existing market.
Mainly to be that low dose of confession is clinical be used for subcutaneous or administered intramuscular the injection preparation specification of already present biological preparation-transfer factor in the market, this route of administration is not suitable for heavy dose of disposable administration, and be not suitable for clinical treatment serious symptom urgent patient, if will run into the difficulty that should not solve during the quick heavy dose of administration of clinical needs and delayed patient's timely treatment, under this background, for solving the needs of treatment clinically.We design to have invented and still do not exist on biological preparation-this market of used for intravenous injection transfer factor and the clinical very this novel formulations preparation technology of needs.Promptly in order to the aseptic water as solvent in the source of reducing phlegm and internal heat, solute can adopt sodium chloride, glucose, xylitol to become the used for intravenous injection transfer factor injection of different capabilities with biological preparation transfer factor and other little phthaleins material compatibility respectively, and this not commensurability big specification new formulation has satisfied clinically for the needs of treatment critical patient with the patient of a large amount of this biological preparation of urgent need.This invention belongs to the intravenous drip administration, and therefore difficulty, the technical merit of the preparation of this invention requirement have improved a lot, belong to the new preparation process that at home and abroad there is no.
It is as follows to prepare several main technique flow processs:
(1) freeze-thaw method:
(1) a certain amount ofly smashs to pieces adding through carrying out high-speed homogenization with the homogenate bruisher behind the no heat source water of pre-cooling through pretreated flesh tissue (tissues such as animal spleen such as pig, cattle, sheep or lymph node) chopping back.
(2) the carrying out-30 ℃-37 ℃ that will smash tissue to pieces through homogenate fast freeze-thaw 2-3 time repeatedly is with smudge cells.
(3) centrifugal with High speed refrigerated centrifuge, get centrifuged supernatant.
(4) supernatant is limit the molecular weight ultrafiltration, molecular cut off 6000 is with the lower part.
(5) the gained ultrafiltrate being added sodium chloride (or adding glucose or xylitol) is mixed with and the jumbo transfer factor needs of the body isoosmotic isotonic liquid confession different big specifications of preparation.
Summary of the invention:
(1) the present invention by in transfer factor stock solution, adding sodium chloride (or add glucose or xylitol) but be mixed with and ooze the transfer factor injection that injection for intravenous uses with human organism etc. and solve the needs of medicine for treatment clinically.
(2) the present invention by in transfer factor stock solution, adding sodium chloride (or add glucose or xylitol) but be mixed with to wait and ooze injection for intravenous is treated heavy dose of medication clinically with heavy dose of transfer factor injection solution needs with the human organism.
(2) complete filtering method:
(1) will smash to pieces with homogenate bruisher high-speed homogenization through pretreated tissue (tissues such as animal spleen such as pig, cattle, sheep or lymph node) below 12 ℃. according to cell crashing ratio, control temperature and homogenate speed are to guarantee active and guarantee the important step of high yield.
(2) getting centrifuged supernatant behind the high speed frozen centrifugation is that the first step filters through the filter press filter pressing, removes crude protein.
(3) carry out from big toward little gradient classification ultrafiltration with the ultrafilter membrane of different size molecular weight, obtain molecular weight and be the ultrafiltrate below 6000.
(4) resulting transfer factor ultrafiltrate being added sodium chloride (or adding glucose or xylitol) is mixed with body etc. and oozes transfer factor liquid for the jumbo transfer factor needs of the different big specifications of preparation.
This preparation technology invention main points are as follows:
(1) the present invention by in transfer factor stock solution, adding sodium chloride (or glucose or xylitol) but be mixed with human organism etc. and ooze injection for intravenous solves medicine for treatment clinically with transfer factor injection needs.
(2) the present invention by in transfer factor stock solution, adding sodium chloride (or add glucose or xylitol) but be mixed with to wait and ooze the needs of injection for intravenous with heavy dose of medication on heavy dose of transfer factor injection solution clinical treatment with the human organism.
Claims (6)
1, used for intravenous injection transfer factor sodium chloride injection technological process.
2, used for intravenous injection transfer factor glucose injection technological process
3, used for intravenous injection transfer factor Xylitol injection technological process
4, sodium chloride is added be mixed with the technological process of isoosmotic transfer factor sodium chloride injection in the transfer factor stock solution.
5, glucose is added be mixed with the technological process of isoosmotic transfer factor glucose injection in the transfer factor stock solution.
6, xylitol is added be mixed with the technological process of isoosmotic transfer factor Xylitol injection in the transfer factor stock solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100464040A CN1583164A (en) | 2004-06-09 | 2004-06-09 | Preparing procedure of transfer factor for intravenous injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100464040A CN1583164A (en) | 2004-06-09 | 2004-06-09 | Preparing procedure of transfer factor for intravenous injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1583164A true CN1583164A (en) | 2005-02-23 |
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ID=34601998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004100464040A Pending CN1583164A (en) | 2004-06-09 | 2004-06-09 | Preparing procedure of transfer factor for intravenous injection |
Country Status (1)
| Country | Link |
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| CN (1) | CN1583164A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1888090A4 (en) * | 2005-05-02 | 2009-08-26 | 4Life Patents Llc | Transfer factor preparations and associated methods |
| CN103316045A (en) * | 2013-06-26 | 2013-09-25 | 西安斯凯达生物制品有限公司 | Combined specific transfer factor for livestock and poultry and preparation method of combined specific transfer factor |
| US9028882B2 (en) | 2005-05-02 | 2015-05-12 | 4Life Patents, Llc | Nutraceutical gels |
| CN109381486A (en) * | 2017-08-08 | 2019-02-26 | 秦皇岛隽凯生物科技有限公司 | A kind of technique preparing transfer factor |
-
2004
- 2004-06-09 CN CNA2004100464040A patent/CN1583164A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1888090A4 (en) * | 2005-05-02 | 2009-08-26 | 4Life Patents Llc | Transfer factor preparations and associated methods |
| AU2006242106B2 (en) * | 2005-05-02 | 2013-01-17 | 4Life Patents, Llc | Transfer factor preparations and associated methods |
| US9028882B2 (en) | 2005-05-02 | 2015-05-12 | 4Life Patents, Llc | Nutraceutical gels |
| US9956258B2 (en) | 2005-05-02 | 2018-05-01 | 4Life Patents, Llc | Transfer factor preparations and associated methods |
| US10363280B2 (en) | 2005-05-02 | 2019-07-30 | 4Life Patents, Llc | Nutraceutical gels |
| US10905732B2 (en) | 2005-05-02 | 2021-02-02 | 4Life Patents, Llc | Transfer factor preparations and associated methods |
| US11857593B2 (en) | 2005-05-02 | 2024-01-02 | 4Life Patents, Llc | Nutraceutical gels |
| CN103316045A (en) * | 2013-06-26 | 2013-09-25 | 西安斯凯达生物制品有限公司 | Combined specific transfer factor for livestock and poultry and preparation method of combined specific transfer factor |
| CN103316045B (en) * | 2013-06-26 | 2015-08-12 | 西安斯凯达生物制品有限公司 | A kind of livestock and poultry multi-joint specific transfer factor and preparation method |
| CN109381486A (en) * | 2017-08-08 | 2019-02-26 | 秦皇岛隽凯生物科技有限公司 | A kind of technique preparing transfer factor |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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