CN1327817A - Antiabortifacient for treating male endocrine sterility and its preparing process - Google Patents

Antiabortifacient for treating male endocrine sterility and its preparing process Download PDF

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CN1327817A
CN1327817A CN00117144A CN00117144A CN1327817A CN 1327817 A CN1327817 A CN 1327817A CN 00117144 A CN00117144 A CN 00117144A CN 00117144 A CN00117144 A CN 00117144A CN 1327817 A CN1327817 A CN 1327817A
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parts
radix
fructus
rhizoma
ethanol
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CN1107516C (en
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彭少芳
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Abstract

An antiabortifacient for treating male endocrine sterility such as aspermia, abornormal sperm, etc. is prepared from 15 Chinese-medicinal materials including dodder seed, achyranthes root, plantain seed, wolfberry fruit, etc. Its preparing process is also disclosed.

Description

Pregnancy promoting medicine of treatment male endocrine infertility and preparation method thereof
The present invention relates to a kind of pregnancy promoting medicine for the treatment of man's and woman's sterility, specifically belonging to the Chinese herbal medicine is the Chinese patent medicine of raw material, the invention still further relates to the preparation method of this medicine.
Infertility is meant under the situation of not taking any contraceptives, gestation arranged after the normality life more than 2 years yet or life birth person is arranged.Chinese medicine is accumulating rich experience aspect the treatment man's and woman's sterility, but Chinese medicine is paid attention to the tonifying liver the kidney invigorating to cure infertility at present, do not embody whole the executing of seeing of the traditional Chinese medical science and control principle, aspect treatment male infertility infertility, use the tonic of a large amount of the kidney invigorating tonifying livers, be difficult for absorbing, get angry easily after eating, curative effect is limited.
The objective of the invention is to propose a kind of efficient, effect is wide, nature and flavor are gentle, it is oral to be difficult for getting angry, be easy to and absorb, and is mainly used in pregnancy promoting medicine of treatment male endocrine infertility and preparation method thereof.
The present invention is based on and suffer from a deficiency of the kidney and the three dirty imbalances of liver spleen are the understanding that causes the mechanism of infertility, the rule of treatment of corresponding formulation " reinforce the kidney, spleen invigorating, accent liver and be in harmonious proportion three dirty ", select and " nature and flavor " compatibility according to medicine " return through ", select in kidney channel, spleen channel, the Liver Channel that clinical efficacy is good, effect is strong for use, have respectively reinforce the kidney, the Chinese medicine of spleen invigorating, accent liver, the purify composition of each medicine of refine is made the pregnancy promoting medicine of this treatment male endocrine infertility.
Medicine of the present invention is made (consumption is a weight portion) by following component:
10~15 parts of Semen Cuscutae, 4.5~10 parts of Radix Achyranthis Bidentataes, 5~12 parts of Semen Plantaginiss, 6~15 parts of Fructus Lycii, 3~6 parts of Fructus Schisandrae Chinensis, 3~10 parts of Fructus Rubies, 10~30 parts of Rhizoma Polygonatis, 3~10 parts of Ramulus Cinnamomi, 3~15 parts of Herba Epimedii, 6~12 parts of Colla cornus cervis, 9~30 parts of Radix Astragali, 9~15 parts of Radix Codonopsis, 4.5~12 parts of Radix Angelicae Sinensis, 3~10 parts of Rhizoma Curculiginises, 2~10 parts in Radix Glycyrrhizae.
The preferred weight proportioning of preparation pharmaceutical formulation of the present invention is:
15 parts of Semen Cuscutae, 10 parts of Radix Achyranthis Bidentataes, 12 parts of Semen Plantaginiss, 15 parts of Fructus Lycii, 5 parts of Fructus Schisandrae Chinensis, 10 parts of Fructus Rubies, 15 parts of Rhizoma Polygonatis, 5 parts of Ramulus Cinnamomi, 15 parts of Herba Epimedii, 2.4 parts of Colla cornus cervis, 30 parts of Radix Astragali, 15 parts of Radix Codonopsis, 12 parts of Radix Angelicae Sinensis, 9 parts of Rhizoma Curculiginises, 5 parts in Radix Glycyrrhizae.
The dosage form of medicine of the present invention can be capsule or pill.
The preparation method of making medicine of the present invention comprises following processing step:
(1) Radix Achyranthis Bidentatae, Fructus Lycii, Fructus Rubi, Ramulus Cinnamomi, Herba Epimedii, Radix Astragali, Radix Codonopsis, Rhizoma Curculiginis, Radix Glycyrrhizae 9 flavor medicines shred respectively in the side of getting, mix, earlier with 80~100 ℃ of hot water lixiviates, to add ethanol after the extract filtering and concentrating to containing alcohol 70%, leave standstill, filter, behind the filtrate recycling ethanol, be condensed into thick paste;
(2) Semen Cuscutae in the side of getting, Semen Plantaginis, Fructus Schisandrae Chinensis, Rhizoma Polygonati, Radix Angelicae Sinensis 5 flavor medicated powder are broken into coarse powder, with 70% ethanol percolation, collect 5 times of amounts of medicinal liquid behind the mixing, and filtration behind the filtrate recycling ethanol, is condensed into thick paste;
(3) merge above-mentioned two kinds of thick pastes, heating makes it to dissolve, and adds the Colla cornus cervi dissolving, stirs, and vacuum drying becomes dry extract, pulverizes, and crosses 80~100 mesh sieves;
(4) with above-mentioned gained medicated powder filled capsules, be the capsule-type dosage form; The medicated powder of above-mentioned gained is added water and honey, make piller, be pill.
For improving the extraction ratio of each medicine composition, in above-mentioned steps (1), described 9 flavor medicines will be used hot water lixiviate secondary, the amount of water of each lixiviate is 10~12 times of doses (weight), each extraction time is no less than 2 hours, the extract filtering and concentrating adds to leave standstill behind the ethanol and is no less than 48 hours, and then filters, reclaims ethanol, is condensed into thick paste.
The kidney warming replenishing essences such as Fructus Rubi, Semen Cuscutae, Rhizoma Curculiginis, Colla cornus cervi, Ramulus Cinnamomi, Herba Epimedii among the side of the present invention, warming the meridian for promoting the flow of YANG QI, Radix Codonopsis, Radix Astragali, Radix Glycyrrhizae, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis benefiting qi and nourishing blood, spleen invigorating and in, Fructus Schisandrae Chinensis, the diuresis of Semen Plantaginis arresting seminal emission, the thread medicine share the merit of playing the kidney warming replenishing essence, benefiting qi and nourishing blood, the spermatogenesis that reinforces the kidney altogether.The present invention's flavour of a drug of writing out a prescription are gentle, can not get angry after eating.
Preparation method of the present invention, the composition of refine purification material medicine, method for making meets the Chinese Pharmacopoeia regulation, and capsule of making or pill are easy to absorb and are oral, help improving curative effect.
Medicine of the present invention proves that this poison of drug is very low, clinical consumption safety through the animal acute toxicity test of Traditional Chinese Medicine University Of Guangzhou's taste institute;
All by the check of Shantou City medicine inspecting institute, the result meets the requirements for the capsule that the present invention makes, pill.
Medicine of the present invention shows to have the effect and the effect of the kidney warming replenishing essence, benefiting vital QI and blood through clinical use, mainly is adapted to male's azoospermia, azoospermia, essence and dyssecretosis infertility within dysspermatism and the cacospermia such as coagulates.
Curative effect for proof medicine of the present invention, the present invention has carried out clinical trial in the hospital of traditional Chinese hospital, Shantou City, Guangdong, method is to select qualified male infertility patient 120 examples, the case selection standard should possess three conditions: 1, normal sexual function and ejaculation function are arranged, but have the low sign of sexual function; 2, performance has unusual sperm; 3, the low and serum FSH of plasma testosterone is normal or low.The endocrine male infertility patient who gets rid of other infertile factors.Divide four groups at random: the first group is taken medicine of the present invention (capsule); The second group is used Chloramiphene and is added HCG; Use HCG for third group and add HMG; The fourth group selects for use medicine of the present invention to add HCG and HMG.Respectively organize curative effect, and, carry out semen efamination simultaneously, observe the variation of treatment back index in the situation of change of take medicine 4 weeks back observation blood FSH, T.Curative effect determinate standard: A, invalid: more than 2 courses of treatment of taking medicine (4 week), sperm concentration and vigor change very little, and density increases less than 1.0 * 10 7/ L, activity ratio still is lower than 50%, and FSH value and T value are not seen significant change, and sexual function does not have improvement; B, effective: seminal fluid, hormone have bigger improvement on former basis, but do not reach minimum normal value, and sexual function makes moderate progress; C, clinical cure: semen efamination, each index of hormone value and sexual function all reach normal value but wife's side unpregnancy; D, healing: become pregnant in the wife's side.
Each organizes the therapeutic outcome curative effect relatively:
First group (taking medicine group of the present invention), 30 examples are cured 16 examples, clinical cure 5 examples, effective 7 examples, invalid 2 examples, effective percentage is 93.6%;
Second group (take Chloramiphene and add the HCG group), 30 examples are cured 9 examples, clinical cure 3 examples, effective 8 examples, invalid 10 examples, effective percentage 66.7%;
Third group (taking HMG and HCG group), 30 examples are cured 12 examples, clinical cure 3 examples, effective 6 examples, invalid 9 examples, effective percentage 70%;
Fourth group (take medicine of the present invention and add HCG and HMG group), 30 examples are cured 16 examples, clinical cure 7 examples, effective 6 examples, invalid 1 example, effective percentage 967%.
Can illustrate that from above-mentioned clinical test results medicine of the present invention is the dysspermatism of treatment incretion infertility and effective Chinese patent medicine of cacospermia.Medicine of the present invention, not only using separately has better curative effect, can cooperate with Western medicine CC again and take, to produce better effect.This medicinal flavor is gentle, is difficult for getting angry, and can uninterruptedly take medicine, and is efficient, easily absorb, and cheap, selection easy for patients to accept.
Embodiment one
Take by weighing raw material by following proportioning:
15 kilograms of Semen Cuscutae, 10 kilograms of Radix Achyranthis Bidentataes, 12 kilograms of Semen Plantaginiss, 15 kilograms of Fructus Lycii, 5 kilograms of Fructus Schisandrae Chinensis, 10 kilograms of Fructus Rubies, 15 kilograms of Rhizoma Polygonatis, 5 kilograms of Ramulus Cinnamomi, 15 kilograms of Herba Epimedii, 2.4 kilograms of Colla cornus cervis, 30 kilograms of Radix Astragali, 15 kilograms of Radix Codonopsis, 12 kilograms of Radix Angelicae Sinensis, 9 kilograms of Rhizoma Curculiginises, 5 kilograms in Radix Glycyrrhizae.
Preparation method is as follows:
(1) Radix Achyranthis Bidentatae, Fructus Lycii, Fructus Rubi, Ramulus Cinnamomi, Herba Epimedii, Radix Astragali, Radix Codonopsis, Rhizoma Curculiginis, Radix Glycyrrhizae 9 flavor medicines are cut respectively, are pulverized in the side of getting, and mix, and described 8 flavor medicines add 12 times of amounts of water, and heated and boiled was collected medicinal liquid after 2 hours; Medicinal residues are added 10 times of amounts of water again, and heated and boiled was collected medicinal liquid after 2 hours; The medicinal liquid of twice collection is merged, filter, be condensed into 1: 1 extractum, put cold back and add ethanol, left standstill 48 hours, and then filter, reclaim ethanol, be condensed into thick paste (30 ℃ are surveyed relative density 1.20~1.25) to containing alcohol 70%;
(2) Semen Cuscutae in the side of getting, Semen Plantaginis, Fructus Schisandrae Chinensis, Rhizoma Polygonati, Radix Angelicae Sinensis 5 flavor medicated powder are broken into coarse powder, behind the mixing with 70% ethanol percolation, 5 times of amounts of collection medicinal liquid, filter, behind the filtrate recycling ethanol, vacuum concentration becomes thick paste (30 ℃ are surveyed relative density 1.20~1.25);
(3) merge above-mentioned two kinds of thick pastes, heating makes fusing, adds the Colla cornus cervi dissolving, stirs, and with an amount of Pulvis Talci disc, becomes dry extract in vacuum drying (below 80 ℃), pulverizes, and crosses 80 mesh sieve secondaries, is filled in " 0 " number capsule, i.e. cost capsule formulation medicine.
Made capsule character: its content is a chocolate brown powder, and mildly bitter flavor is puckery, and is sweet, gas perfume (or spice).
This product usage and dosage is: every capsules contains active ingredient 600mg, and once oral 4, every day three times, or follow the doctor's advice.
Embodiment two
Take by weighing raw material by following proportioning:
25 kilograms of Semen Cuscutae, 15 kilograms of Radix Achyranthis Bidentataes, 18 kilograms of Semen Plantaginiss, 15 kilograms of Fructus Lycii, 6 kilograms of Fructus Schisandrae Chinensis, 10 kilograms of Fructus Rubies, 30 kilograms of Rhizoma Polygonatis, 10 kilograms of Ramulus Cinnamomi, 15 kilograms of Herba Epimedii, 12 kilograms of Colla cornus cervis, 30 kilograms of Radix Astragali, 15 kilograms of Radix Codonopsis, 15 kilograms of Radix Angelicae Sinensis, 10 kilograms of Rhizoma Curculiginises, 8 kilograms in Radix Glycyrrhizae.
Its preparation method (1), (2) two steps are identical with embodiment one, and (3) goes on foot and to become piller with processed with honey for prepared medicated powder is added water, pill medicine of the present invention.
Made pill character: be light, rounding, the uniform brownish black piller of color and luster, ball heart taupe, feeble QI perfume (or spice), sweet in the mouth, hardship, suffering, little salty.

Claims (5)

1. pregnancy promoting medicine for the treatment of the male endocrine infertility is characterized in that it is the medicament of being made by the following weight proportion raw material:
10~15 parts of Semen Cuscutae, 4.5~10 parts of Radix Achyranthis Bidentataes, 5~12 parts of Semen Plantaginiss, 6~15 parts of Fructus Lycii, 3~6 parts of Fructus Schisandrae Chinensis, 3~10 parts of Fructus Rubies, 10~30 parts of Rhizoma Polygonatis, 3~10 parts of Ramulus Cinnamomi, 3~15 parts of Herba Epimedii, 6~12 parts of Colla cornus cervis, 9~30 parts of Radix Astragali, 9~15 parts of Radix Codonopsis, 4.5~12 parts of Radix Angelicae Sinensis, 3~10 parts of Rhizoma Curculiginises, 2~10 parts in Radix Glycyrrhizae.
2. pregnancy promoting medicine according to claim 1 is characterized in that wherein the weight proportion of each raw material is:
15 parts of Semen Cuscutae, 10 parts of Radix Achyranthis Bidentataes, 12 parts of Semen Plantaginiss, 15 parts of Fructus Lycii, 5 parts of Fructus Schisandrae Chinensis, 10 parts of Fructus Rubies, 15 parts of Rhizoma Polygonatis, 5 parts of Ramulus Cinnamomi, 15 parts of Herba Epimedii, 2.4 parts of Colla cornus cervis, 30 parts of Radix Astragali, 15 parts of Radix Codonopsis, 12 parts of Radix Angelicae Sinensis, 9 parts of Rhizoma Curculiginises, 5 parts in Radix Glycyrrhizae.
3. pregnancy promoting medicine according to claim 1 and 2, the dosage form that it is characterized in that said medicament is capsule or pill.
4. the preparation method of the described pregnancy promoting medicine of claim 3 is characterized in that step of preparation process is as follows:
(1) Radix Achyranthis Bidentatae, Fructus Lycii, Fructus Rubi, Ramulus Cinnamomi, Herba Epimedii, Radix Astragali, Radix Codonopsis, Rhizoma Curculiginis, Radix Glycyrrhizae 9 flavor medicines shred respectively in the side of getting, mix, earlier with 80~100 ℃ of hot water lixiviates, to add ethanol after the extract filtering and concentrating to containing alcohol 70%, leave standstill, filter, behind the filtrate recycling ethanol, be condensed into thick paste;
(2) Semen Cuscutae in the side of getting, Semen Plantaginis, Fructus Schisandrae Chinensis, Rhizoma Polygonati, Radix Angelicae Sinensis 5 flavor medicated powder are broken into coarse powder, with 70% ethanol percolation, collect 5 times of amounts of medicinal liquid behind the mixing, and filtration behind the filtrate recycling ethanol, is condensed into thick paste;
(3) merge above-mentioned two kinds of thick pastes, heating makes it to dissolve, and adds the Colla cornus cervi dissolving, stirs, and vacuum drying becomes dry extract, pulverizes, and crosses 80~100 mesh sieves;
(4) with above-mentioned gained medicated powder filled capsules, be the capsule-type dosage form; The medicated powder of above-mentioned gained is added water and honey, make piller, be pill.
5. the preparation method of pregnancy promoting medicine according to claim 4, it is characterized in that in the step (1), the medicinal hot water lixiviate secondary of described 9 flavors, the amount of water of each lixiviate is 10~12 times of doses (weight), each extraction time is no less than 2 hours, the extract filtering and concentrating adds to leave standstill behind the ethanol and is no less than 48 hours, and then filters, reclaims ethanol, is condensed into thick paste.
CN00117144A 2000-06-08 2000-06-08 Antiabortifacient for treating male endocrine Sterility and its preparing process Expired - Fee Related CN1107516C (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102727714A (en) * 2012-07-03 2012-10-17 许瑞琴 Traditional Chinese medicinal capsule for treating azoospermia
CN102836382A (en) * 2012-10-09 2012-12-26 彭少芳 Kidney-tonifying and embryo-developing externally-applied plaster

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102727714A (en) * 2012-07-03 2012-10-17 许瑞琴 Traditional Chinese medicinal capsule for treating azoospermia
CN102836382A (en) * 2012-10-09 2012-12-26 彭少芳 Kidney-tonifying and embryo-developing externally-applied plaster
CN102836382B (en) * 2012-10-09 2013-09-04 彭少芳 Kidney-tonifying and embryo-developing externally-applied plaster

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