CN1311014A - Chinese herbal granule for curing headache and its preparing method - Google Patents
Chinese herbal granule for curing headache and its preparing method Download PDFInfo
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Abstract
The present invention relates to Chinese prescription medicine for treating headache, it is composed of (wt. portions); ligusticum root 600-1000, white peony root 100-400, cyperus root 100-400, radix bupleuri 100-400, radix scutellariae 100-400, radix angelicae dahuricae 100-400, rhizoma pinelliae 100-400, rhizoma gastrodiae 100-400, rhizome corydalis decumbentis 100-400, the optimum shape of said medicine is in the form of granulation.
Description
The invention discloses a kind of Chinese medicine preparation for the treatment of headache, said preparation is to be the Chinese patent medicine that feedstock production forms with the Chinese herbal medicine, belongs to the field of Chinese medicines.
Headache is a kind of commonly encountered diseases, frequently-occurring disease, is one of disease of serious harm human health, has the data investigation to show, the sickness rate of healthy people's headache is 64%, and wherein 18% excuse is gone to a doctor bitterly.Headache is meant the pain of volume, top, temporo, occipitalia, and its pathogenesis is more and complicated.
China's medical science is thought, pain can be divided into headache due to invasion of exogenous pathogens and headache due to internal injury two big classes, careless more than the headache due to invasion of exogenous pathogens because of daily life, sit, crouch, row, station are experienced wind, cold, wet, outside pathogen such as heat, headache due to internal injury is mostly relevant with internal organs such as liver, lung, kidney, spleen, stomaches, so saying of headache due to hyperactivity of liver-YANG, headache due to deficiency of the kidney, the turbid headache of expectorant, headache due to blood stasis, headche due to wind-cold, headache due to pathogenic wind-heat, headache due to pathogenic wind-dampness arranged.
Modern medicine is thought, when pathological change takes place in the sensitive organization of head, easily cause headache, for example: blood vessel is pulled, oppresses, the meninges irriate, brain neuroblastoma tissue damaged hinders, face pathological changes etc. are so have migraine, tension headache, nervous headache, triggering headache, vascular headache etc.
The method of treatment headache at present has acupuncture method, physical therapy method, massotherapy, drug blockage method, medicine for external use semar technique, Western medicine method for oral administration, intramuscular injection etc., but weak point is all arranged.
Acupuncture method patient is painful big, and what have easily has a fainting spell during acupuncture treatment; Physical therapy method equipment is complicated, and curative effect is slow, can not effect a permanent cure; Massotherapy can only emergence therapeutic monopagia; The drug blockage method can only emergence therapeutic, it is short to hold time, range of application is little; The medicine for external use semar technique can only be treated monopagia, and the drug absorption rate is low; Western medicine method for oral administration, for example aspirin, somedon, morphine class medicine can only symptomatic treatments, and the weak point of holding time has side effect mostly, and influential to stomach, spleen, liver, kidney, what have easily makes patient habit-forming, and medicine is had dependency.
The present invention seeks at the method for existing treatment headache and the weak point of medicine, a kind of Chinese medicine that can the multiple headache of Comprehensive Treatment is provided.
Medicament of the present invention is to be that feedstock production forms with following parts by weight of Chinese traditional medicine compositions:
Rhizoma Chuanxiong 600-1000 part Radix Paeoniae Alba 100-400 part Rhizoma Cyperi 100-400 part
Radix Bupleuri 100-400 part Radix Scutellariae 100-400 part Radix Angelicae Dahuricae 100-400 part
Rhizoma Pinelliae 100-400 part Rhizoma Gastrodiae 100-400 part Rhizoma Corydalis 300-500 part
Rhizoma Corydalis Decumbentis 100-400 part
In the middle of the aforementioned pharmaceutical compositions, the preferred weight ratio of each constituent is:
Rhizoma Chuanxiong 840 Radix Paeoniae Albas 252 Rhizoma Cyperis 252 Radix Bupleuri 252
Radix Scutellariae 252 Radixs Angelicae Dahuricae 252 Rhizoma Pinelliaes 252 Rhizoma Gastrodiaes 252
Rhizoma Corydalis 420 Rhizoma Corydalis Decumbentiss 252
Rhizoma Cyperi in the middle of the aforementioned pharmaceutical compositions preferably is suitable for Rhizoma Cyperi (processed).
Use above-mentioned pharmaceutical composition to be raw material,, can be prepared into pharmaceutical preparation commonly used, preferred particulates agent of the present invention according to the preparation process of routine.
The preparation method of medicinal granule of the present invention is as follows
More than ten flavors, Rhizoma Corydalis, Rhizoma Corydalis Decumbentis is with twice of 60-80% alcohol reflux.Add for the first time 3-5 and doubly measure extraction 1-2 hour, add 2-4 for the second time and doubly measure extraction 1-2 hour, filter, filtrate merges, and recovery ethanol is concentrated into clear paste (relative density is 1.35,60 ℃ of surveys), and 80 ℃ of drying under reduced pressure get dry extract, and are standby.All the other eight flavor medicines such as Rhizoma Chuanxiong decoct with water, for the first time adding 5-8 times of decocting boiled 1-2 hour, for the second time adding 4-6 times of decocting boiled 0.5-1 hour, add 3-6 times of decocting for the third time and boiled 0.5-1 hour, filter, three decocting liquid merging are concentrated into flowing soaking paste, and (relative density is 1.04-1.06,80 ℃ of surveys), add an amount of ethanol and make the alcohol amount of containing be 40-60%, left standstill 24 hours, filter, 40-50% washing with alcohol precipitation, filtrate recycling ethanol is concentrated into clear paste (relative density 1.30-1.35,80 ℃), 80 ℃ of drying under reduced pressure, dried cream and Rhizoma Corydalis, the dried cream of Rhizoma Corydalis Decumbentis mixes to be pulverized, cross 80 mesh sieves, 1 part in the powder of getting it filled, 1 part in dextrin, 1 part of mixing of cane sugar powder adds 0.5% steviosin, the moistening granulation of 95% ethanol, cold drying, granulate is made the 1000g granule.
Medicine of the present invention proves through experimentation, has analgesia, calmness, improves effect such as cerebral circulation, can be used for treating various types of headaches clinically.Experimental example one drug particles of the present invention (the trade name universe is clear) is subjected to the reagent thing to the test material that influences of rat platelet aggregation and blood viscosity: 1. the clear granule of universe: the powder that test is made with this medicine extraction clear paste, 12.5g crude drug/g powder, provide lot number by Ruifulai Pharmaceutic Co., Ltd., Shanxi Prov: 991201.2. Aspirin Enteric-coated Tablets (25mg/ sheet): Hai Derun pharmaceutical Co. Ltd in Beijing produces, lot number: 981104.3. adenosine diphosphate (ADP) (ADP) disodium salt: Shanghai Inst. of Biochemistry, Chinese Academy of Sciences produces, lot number: 9209258.Be mixed with the solution of 1.0mM/L with normal saline, 4 ℃ of preservations are standby.Animal: 50 healthy male Wistar rats, body weight 249.5 ± 23.6g is provided by China Academy of TCM's medical experiment animal center, the quality certification number: the moving word of doctor 01-3067 number.Instrument: platelet aggregation instrument, BS634 type, Beijing biochemical instrument factory product; The blood viscosity measuring instrument, LG-R-20 type, Beijing Steellex Scientific Instrument Company's product.Test method
50 rats are divided into 5 groups (10 every group) at random: 1. matched group (distilled water, 10ml/kg), 2. (3g crude drug/kg) is (the 6g crude drug/kg) of dosage group in the clear granule of universe 3. for the clear granule small dose group of universe, 4. the heavy dose of group of the clear granule of universe (12g crude drug/kg), 5. aspirin group (50mg/kg).Each group is pressed described dosage gastric infusion, once a day, successive administration 7 days, 1h after the last administration, pentobarbital sodium (30.0mg/kg) anesthesia, abdominal aortic blood is measured platelet aggregation rate and blood viscosity.
Platelet aggregation rate assay method: with silication syringe puncture abdominal aortic blood 3ml, 3.8% liquor sodii citratis anticoagulant (blood: anticoagulant=9: 1), centrifugal 8 minutes of 200 * g, getting supernatant partly is platelet rich plasma (PRP), centrifugal 10 minutes of remainder 2200 * g, getting supernatant partly is platelet poor plasma (PPP).Platelet count is 6.0 * 10 among the PRP
5/ mm
3About.According to the BornShi turbidimetry, the opacity tube that fills 200ulPRP and 1 little bar magnet is placed platelet aggregation instrument, 37 ℃ are incubated 1 minute, after PPP demarcates, add derivant and induce gathering under stirring state.The final concentration of used derivant is: ADP (47.6 μ M/L).Analyze the influence of medicine according to gathering curve and maximum agglutination rate that instrument prints automatically to platelet aggregation.The maximum agglutination rate computing formula is as follows:
The blood viscosity assay method: with silication syringe puncture abdominal aortic blood 3ml (anticoagulant heparin), draw 0.8ml and be used for whole blood viscosity mensuration, surplus blood is got supernatant 0.8ml and is used for plasma viscosity mensuration in the centrifugal 10min of 650 * g.Require to operate in strict accordance with LG-R-20 type blood viscosity analyzer description.Result of the test is to the influence of platelet aggregation
The results are shown in Table 1.
The clear granule of table 1. universe is to the influence of rat platelet aggregation rate (X ± SD)
| Group | Dosage (/kg) | Mus number (only) | Aggregation rate (%) |
| The clear groups of grains aspirin of matched group universe group | 39 crude drug 6g crude drug 12g crude drug 50mg | ????10 ????10 ????10 ????10 ????10 | ????65.66±9.47 ????62.93±11.47 ????57.95±8.35 ????53.90±6.11 **????52.29±7.22 ** |
Annotate: compare with matched group
*P＜0.01.
By table 1 as seen, the platelet aggregation rate of the heavy dose of group of the clear granule of universe significantly is lower than matched group (P＜0.01), the platelet aggregation rate of dosage group and matched group relatively have downward trend in the clear granule of universe, and the platelet aggregation rate of the clear granule small dose group of universe and matched group be no significant difference relatively.The platelet aggregation rate of aspirin group also significantly is lower than matched group (P＜0.01).Influence to blood viscosity
The results are shown in Table 2
The clear granule of table 2. universe is to the influence of rat blood viscosity (n=10, X ± SD)
Annotate: compare with matched group
*P＜0.05,
*P＜0.01,
* *P＜0.001.
| Group | Dosage (/kg) | Whole blood viscosity (CP) | Plasma viscosity (CP) | |||
| Height is cut (200S -1) | In cut (100S -1) | In cut (30S -1) | Low (the 5S that cuts -1) | |||
| The clear groups of grains aspirin of matched group universe group | 39 crude drugs, 69 crude drugs, 129 crude drug 50mg | 4.77±0.25 4.75±0.21 4.53±0.34 3.90±0.78 **4.22±0.65 * | 6.13±0.33 6.00±0.22 5.81±0.42 4.62±1.16 ***5.11±1.04 ** | 10.09±0.80 9.59±0.95 9.44±0.68 6.59±2.38 ***7.06±1.93 *** | 18.43±2.10 17.08±2.80 17.21±1.48 10.52±5.08 ***10.86±4.02 *** | ?3.27±0.12 3.22±0.16 3.25±0.14 2.13±1.07 **2.33±1.01 ** |
By table 2 as seen, the whole blood viscosity of the heavy dose of group of the clear granule of universe rat all significantly is lower than matched group (P＜0.01～0.001) under each shear rate; The whole blood viscosity of dosage group rat relatively has downward trend with matched group in the clear granule of universe under each shear rate; Whole blood viscosity of the clear granule small dose group of universe rat and matched group be no significant difference relatively.The whole blood viscosity of aspirin group rat all is starkly lower than matched group (P＜0.05～0.001) under each shear rate.Plasma viscosity of heavy dose of group of the clear granule of universe and aspirin group rat and matched group more obviously reduce (P＜0.01), and plasma viscosity of other group rat and matched group be no significant difference relatively.
The above results shows: continuous 7 days gastric infusions, the clear granule 12g of universe crude drug/kg significantly reduces the inductive rat platelet aggregation rate of adenosine diphosphate (ADP) (ADP) (P＜0.01), significantly reduce the whole blood viscosity (P＜0.01～0.001) of rat under each shear rate, reduce plasma viscosity (P＜0.01) simultaneously.The clear granule of prompting universe has the effect of anticoagulant and blood viscosity lowering.The clear granule of experimental example two universe influences the test material medicine to mice headache model: the clear granule of universe extracts dry extract, and 12.5g crude drug/g is provided by Ruifulai Pharmaceutic Co., Ltd., Shanxi Prov, lot number: 991201; The YUANHU ZHITONG KELI agent, the 5g/ bag, Shenyang flying dragon pharmaceutical Co. Ltd produces, lot number: 980601; Ergotamine and caffeine tablet, gynergen 1mg, caffeine 100mg/ sheet, the Medical University Of Tianjin pharmaceutical factory produces, lot number: 980907; The reserpine injection, red flag pharmaceutical factory of Shanghai Medical Univ produces, lot number: 970505.Above medicine all is made into desired concn during test.Norepinephrine (NE), 5-hydroxy tryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), 3,4 dihydroxy benzylamines (DHBA), triethylamine (TEA), 1-sodium heptanesulfonate (HSA) are the Sigma product; Phosphoric acid (PA), acetonitrile (ACN), methanol, perchloric acid, sodium pyrosulfite, tetrasodium ethylenediamine tetraacetate (EDTA) and other reagent are homemade AR level.Water is DDW.Animal: 70 of Kunming mouses, 18～20g, male and female half and half, Test Animal Centre, Academy of Military Medical Sciences, P.L.A provides, the moving word 01-3023 of doctor.Instrument: CC-5 high performance liquid chromatograph and chromatographic work station (the computerized integrator of CHEM-LAB), the PM-80 pump, the LC-4C electrochemical detector, Monochrom pillar (C18 3 μ m, 100 * 3.0 μ m) add the SecurityGuard front pillar, vitreous carbon working electrode and Ag/AgCl reference electrode, 7125 injection valves are U.S. BAS company products, and the CMA/260 depassing unit is Sweden's product.1. chromatographic condition: mobile phase is formed: HSA1.75g, TEA3.5ml, PA4.0ml, ACN62.5ml, EDTA0.1g, distilled water 930ml, 1000ml altogether.The flow velocity of mobile phase is 0.7ml/min, and the Electrochemical Detection running voltage is 750mv, gains to be 50nA.Cleaning mobile phase is methanol: water (volume)=2: 3.2. the preparation of titer: accurately take by weighing NE, 5-HT, each 10mg of 5-HIAA, DHBA and be dissolved in respectively in the perchloric acid of 100ml 0.1mol/L, deposit in-20 ℃ of refrigerators as storing solution (100 μ g/ml).Getting NE, the 5-HT that is diluted to 10 μ gml, each 1ml of deposit of 5-HIAA respectively mixes, add mobile phase 27ml the hybrid standard liquid of 6400pg/20 μ l, oppose with mobile phase and doubly to dilute the hybrid standard liquid of making 3200pg/20 μ l, 1600pg/20 μ l, 800pg/20 μ l, 400pg/20 μ l respectively; Get the DHBA storing solution and be diluted to the working solution of the solution of 0.1 μ g/ml (containing 0.04% sodium pyrosulfite and 0.04%EDTA) with the perchloric acid of 0.2mol/L as mark and protein precipitant in containing.Above working standard liquid and interior mark liquid use in 2 weeks 4 ℃ of preservations.Experimental technique
Animal is divided into 5 groups at random, 10 every group: blank group, model group, the clear granule 4g crude drug of universe/kg group, the clear granule 8g crude drug of universe/kg group, the clear granule 16g crude drug of universe/kg group, YUANHU ZHITONG KELI 4g crude drug/kg group, ergotamine and caffeine tablet 0.25mg+25mg/kg group.
Animal is pressed 20ml/kg volume gastric infusion, once a day, continuous ten days, subcutaneous injection of reserpine 1mg/kg at once after the last administration, blank group injection equivalent normal saline, the rapid broken end in 1mm place after the mouse ear takes out brain and brain stem rapidly behind the 4hr, liquid nitrogen solidifies, and preserves in-20 ℃ of refrigerators.Cerebral tissue is weighed, every 100mg cerebral tissue adds mark liquid in the ice-cold work of 2ml, in ice bath with electronic glass homogenizer homogenate (fixed rotating speed and homogenate number of times), the 0-4 ℃ of centrifugal 20mm of 1400 * g, extract the nutsch filter sucking filtration of supernatant with 0.22 μ m filter membrane and syringe type, the filtrate packing, be stored in-20 ℃ of refrigerators to be measured.Get 20 μ l and inject HPLC mensuration, the result carries out statistical procedures.Experimental result
Stratographic resolution and standard curve: the hybrid standard of the NE of series concentration, 5-HT, 5-HIAA respectively adds mark DHBA in the constant, injects the HPLC-EC systematic analysis.The result shows, under this experiment condition, the concentration of standard substance in 04-3.2ng/ μ l scope and between the ratio of peak in favorable linearity.The retention time of NE, 5-HIAA, 5-HT and DHBA is respectively 2.5,5.7,13.1 and 3.6min.
The mensuration of 5-HT, 5-HIAA, NE level in the brain: compare with the blank group, 5-HT content obviously reduces in the 4hr behind the mouse subcutaneous injection reserpine, brain, and 5-HIAA content obviously raises, show that reserpine makes 5-HT exhaustion in the brain, its metabolite 5-HIAA increases.Compare with model group, 5-HT content obviously raises in clear three the dosage group brains of universe, and the 5-HIAA content of three dosage groups also obviously raises, and the NE level obviously reduces; Contrast medicine YUANHU ZHITONG KELI group 5-HT, 5-HIAA content obviously raise, and NE content obviously reduces; Positive drug ergotamine and caffeine tablet group 5-HT, 5-HIAA content obviously raise, and NE does not have notable difference (seeing attached list .).The clear granule of subordinate list universe is to the influence of 5-HT, 5-HIAA, NE in the mouse brain
Annotate: compare with the blank group: ###P＜0.001; Compare with model group:
*P＜0.05,
*P＜0.01,
* *P＜0.001
| Group | Dosage | Number of animals | ????5-HT | ????5-HIAA | ????NE |
| ????(/kg) | ????(n) | (the ng/g brain is heavy) | (the ng/g brain is heavy) | (the ng/g brain is heavy) | |
| The clear groups of grains ergotamine and caffeine tablet of blank group model group universe constituent element is the pain relieving groups of grains recklessly | 4g crude drug 8g crude drug 16g crude drug 0.25+25mg 4g | ????10 ????10 ????10 ????10 ????10 ????10 ????10 | 2387.0±661.0 541.1±225.6### 862.0±178.6 *873.4±80.3 *831.9±145.8 *1008.7±186.4 ***836.9±180.8 * | 626.0±256.8 1641.2±390.4### 2420.9±390.2 ***2812.7±466.2 ***2760.1±371.1 ***3318.5±562.0 ***2454.3±396.3 *** | 1505.9±247.5 1311.2±392.5 785.9±369.1 **????(n=6) 1150.4±206.7 973.7±405.0 * |
Subcutaneous injection of reserpine is adopted in test, causes the metabolism disorder of mouse brain endogenous material, has observed the influence of the clear granule of universe to 5-hydroxy tryptamine in the brain (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), norepinephrine (NE) etc.
Result of the test shows that this medicine can increase the content of interior 5-HT of mouse brain and metabolite 5-HIAA thereof, obviously reduces the content of NE.Prompting, the clear granule of universe may be machine-processed therewith relevant to the therapeutical effect of headache, and further mechanism research remains deeply to be inquired into from now on.The clear particulate analgesic activity test material medicine of experimental example three universe: the clear granule of universe extracts dried clear paste, and 12.5g crude drug/g is provided by Ruifulai Pharmaceutic Co., Ltd., Shanxi Prov, lot number: 991201; The corydalis tuber analgesic electuary, the 5g/ bag, Shenyang flying dragon pharmaceutical Co. Ltd produces, lot number: 980601; Above medicine all is made into desired concn during experiment; Pethidine hydrochloride, 50mg/ml, lot number: 940428, normal saline is made into 0.5mg/ml during test; Glacial acetic acid, Beijing Chemical Plant, lot number 901212.Animal: 120 of Kunming mouses, female 90, male 30,18-20g; The moving word of＜doctor is provided by Test Animal Centre, Academy of Military Medical Sciences, P.L.A〉01-3023 number.Experimental technique
Animal is divided into 6 groups at random, 10 every group: the blank group, and the clear granule 4g crude drug of universe/Kg group, the clear granule 8g crude drug of universe/Kg group, the clear granule 16g crude drug of universe/Kg group, corydalis tuber analgesic 4g/Kg group, pethidine hydrochloride 13mg/kg organizes (lumbar injection).Mice acetic acid stimulus method
Animal (male and female half and half) is irritated stomach (20ml/Kg) administration three days, 60min after the last administration, the abdominal cavity injects 0.6% acetic acid (10ml/kg), positive drug group pethidine hydrochloride and acetic acid inject simultaneously, observe in the 15min animal and turn round the body number of times, shrink with abdominal part cave in, the body distortion, hind leg stretches and positive reaction such as crawling.The result carries out statistical procedures (t check).The mice hot plate method
Press literature method, 55 ℃ ± 0.5 ℃ hot plate carries out preliminary election to jenny, and the record medicine preceding threshold of pain, qualified animal gastric infusion once, after the administration 60,120min observe the mice medicine after the threshold of pain, between organizing relatively (t check).The influence (seeing Table 1) that the clear granule of experimental result universe is pain caused to mice acetic acid
Experimental result confirms that the clear granule 16g crude drug of universe/kg dosage has tangible analgesic effect, and the pain reaction of animal obviously alleviates behind the abdominal cavity injection acetic acid, turns round the body number of times and is starkly lower than blank group (P＜0.01).YUANHU ZHITONG KELI group and positive drug pethidine hydrochloride group pain reaction also obviously alleviate, and relatively turn round the body number of times with the blank group and significantly reduce (P＜0.01).The influence pain caused to mice acetic acid of the clear granule of table 1 universe (± SD)
Annotate: compare with the blank group
*The influence pain caused to hot plate of P＜clear granule of 0.01. universe influence (see Table 2) table 2. universe clear granule pain caused to hot plate (X ± SD)
Annotate: compare with the blank group
*P＜0.05,
*P＜0.01
| Grouping dosage number of animals is turned round the body number of times |
| Clear groups of grains 4g crude drug/Kg 10 31.4 ± 10.3 8g crude drug/Kg of blank group 10 38.8 ± 8.6 universe 10 31.8 ± 11.7 16g crude drug/Kg 10 25.1 ± 9.8 **Corydalis tuber analgesic group 4g crude drug/Kg 10 23.2 ± 9.2 **Pethidine hydrochloride group 13mg/Kg 10 5.8 ± 3.9 ** |
| Grouping dosage (/Kg) (second) before the number of animals medicine | Behind the medicine (second) |
| ????60min?????????120min | |
| The clear groups of grains 4g crude drug 10 21.2 of blank group 10 22.2 ± 5.3 23.2 ± 7.8 21.2 ± 8.0 universe ± 6.3 22.2 ± 5.8 20.6 ± 5.6 8g crude drugs 10 22.1 ± 10.4 24.7 ± 10.5 24.2 ± 8.5 16g crude drug 10 21.5 ± 6.2 26.1 ± 5.7 23.8 ± 6.9 YUANHU ZHITONG KELI group 4g crude drugs 10 23.6 ± 9.5 29.7 ± 7.5*25.8 ± 8.0 pethidine hydrochloride group 13mg/Kg 10 21.2 ± 7.0 31.9 ± 7.1 **????29.5±4.0 ** | |
By table 2 as seen, 60min and 90min behind the medicine, the time that blank group mice licks metapedes does not obviously change, and three dosage groups of the clear granule of universe are licked also unobvious change of metapedes time; 60min and blank group relatively have significant analgesic activity (P＜0.05) behind the contrast medicine YUANHU ZHITONG KELI medicine, and 60～120min and blank group more also have significant analgesic activity (P＜0.01) behind the positive drug pethidine hydrochloride group medicine.
Experimental result confirms, the clear granule of universe has a significant protective effect to chemical stimulation is pain caused, with the blank group significant difference is arranged relatively; Thermostimulation there is not significant analgesia role.
Embodiment
Prescription:
Rhizoma Chuanxiong 840g Radix Paeoniae Alba 252g Rhizoma Cyperi (processed) 252g Radix Bupleuri 252g
Radix Scutellariae 252g Radix Angelicae Dahuricae 252g Rhizoma Pinelliae 252g Rhizoma Gastrodiae 252g
Rhizoma Corydalis 420g Rhizoma Corydalis Decumbentis 252g
Method for making:
More than ten the flavor, Rhizoma Corydalis, twice of Rhizoma Corydalis Decumbentis 70% alcohol reflux.Add for the first time 4 times of amounts and extracted 1.5 hours, add 3 times of amounts for the second time and extracted 1.5 hours, filter, filtrate merges, and reclaims ethanol and is concentrated into clear paste (relative density is 1.35,60 ℃ of surveys), and 80 ℃ of drying under reduced pressure get dry extract, and are standby.Eight flavor medicines such as Rhizoma Chuanxiong decoct with water, for the first time adding 7 times of decoctings boiled 1 hour, for the second time adding 5 times of decoctings boiled 0.5 hour, add 5 times of decoctings for the third time and boiled 0.5 hour, filter, three decocting liquid merging are concentrated into flowing soaking paste, and (relative density is 1.04-1.06,80 ℃ of surveys), add an amount of ethanol and make that to contain alcohol amount be 50%, left standstill 24 hours, filter, 50% washing with alcohol precipitation, filtrate recycling ethanol is concentrated into clear paste (relative density 1.30-1.35,80 ℃), 80 ℃ of drying under reduced pressure, dried cream and Rhizoma Corydalis, the dried cream of Rhizoma Corydalis Decumbentis mixes to be pulverized, cross 80 mesh sieves, 1 part in the powder of getting it filled, 1 part in dextrin, 1 part of mixing of cane sugar powder adds 0.5% steviosin, the moistening granulation of 95% ethanol, cold drying, granulate is made the 1000g granule.
Claims (5)
1, a kind of Chinese patent medicine for the treatment of headache, the raw material that it is characterized in that preparing this medicine are formed and are counted with weight portion:
Rhizoma Chuanxiong 600-1000 part Radix Paeoniae Alba 100-400 part Rhizoma Cyperi 100-400 part
Radix Bupleuri 100-400 part Radix Scutellariae 100-400 part Radix Angelicae Dahuricae 100-400 part
Rhizoma Pinelliae 100-400 part Rhizoma Gastrodiae 100-400 part Rhizoma Corydalis 300-500 part
Rhizoma Corydalis Decumbentis 100-400 part
2,, it is characterized in that in the middle of the aforementioned pharmaceutical compositions that the weight ratio of each constituent is according to the Chinese patent medicine of claim 1:
Rhizoma Chuanxiong 840 Radix Paeoniae Albas 252 Rhizoma Cyperis 252 Radix Bupleuri 252
Radix Scutellariae 252 Radixs Angelicae Dahuricae 252 Rhizoma Pinelliaes 252 Rhizoma Gastrodiaes 252
Rhizoma Corydalis 420 Rhizoma Corydalis Decumbentiss 252
3,, it is characterized in that also containing excipient according to the Chinese patent medicine of claim 1 or 2.
4, the preparation method of the described Chinese patent medical granule of claim 3 is characterized in that this method comprises: in the described crude drug, and Rhizoma Corydalis, Rhizoma Corydalis Decumbentis adds 3-5 for the first time and doubly measures extraction 1-2 hour with 60-80% alcohol reflux twice, adds 2-4 for the second time and doubly measures extraction 1-2 hour, filter, filtrate merges, and reclaims ethanol and is concentrated into clear paste, 80 ℃ of drying under reduced pressure get dry extract, standby, all the other eight flavor medicines such as Rhizoma Chuanxiong decoct with water, and add 5-8 times of decocting for the first time and boil 1-2 hour, for the second time adding 4-6 times of decocting boiled 0.5-1 hour, add 3-6 times of decocting for the third time and boiled 0.5-1 hour, filter, three decocting liquids merging are concentrated into flowing soaking paste, adding ethanol makes the alcohol amount of containing be 40-60%, left standstill 24 hours, and filtered, 40-50% washing with alcohol precipitation, filtrate recycling ethanol is concentrated into clear paste, 80 ℃ of drying under reduced pressure, dried cream and Rhizoma Corydalis, the dried cream of Rhizoma Corydalis Decumbentis mixes to be pulverized, and crosses 80 mesh sieves, get it filled 1 part in powder, 1 part in dextrin, 1 part of mixing of cane sugar powder, add 0.5% steviosin, the moistening granulation of 95% ethanol, cold drying, granulate is made granule.
5, the Chinese medicine granules of treatment headache is characterized in that component and technology comprise:
Rhizoma Chuanxiong 840g Radix Paeoniae Alba 252g Rhizoma Cyperi (processed) 252g Radix Bupleuri 252g
Radix Scutellariae 252g Radix Angelicae Dahuricae 252g Rhizoma Pinelliae 252g Rhizoma Gastrodiae 252g
Rhizoma Corydalis 420g Rhizoma Corydalis Decumbentis 252g
More than ten flavors, Rhizoma Corydalis, Rhizoma Corydalis Decumbentis 70% alcohol reflux twice adds for the first time 4 times of amounts and extracted 1.5 hours, add for the second time 3 times of amounts and extracted 1.5 hours, filter, filtrate merges, reclaim ethanol and be concentrated into 60 ℃ to record relative density be 1.35 clear paste, 80 ℃ of drying under reduced pressure get dry extract, and are standby; All the other eight flavor medicines such as Rhizoma Chuanxiong decoct with water, for the first time adding 7 times of decoctings boiled 1 hour, for the second time adding 5 times of decoctings boiled 0.5 hour, adding 5 times of decoctings for the third time boiled 0.5 hour, filter, three decocting liquids merge and are concentrated into 80 ℃ and record the flowing soaking paste that relative density is 1.04-1.06, add ethanol and make that to contain the alcohol amount be 50%, leave standstill 24 hours, filter, 50% washing with alcohol precipitation, filtrate recycling ethanol is concentrated into 80 ℃ of clear paste that record relative density 1.30-1.35,80 ℃ of drying under reduced pressure, dried cream and Rhizoma Corydalis, the dried cream of Rhizoma Corydalis Decumbentis mixes to be pulverized, cross 80 mesh sieves, 1 part in the powder of getting it filled, 1 part in dextrin, 1 part of mixing of cane sugar powder adds 0.5% steviosin, the moistening granulation of 95% ethanol, cold drying, granulate is made the 1000g granule.
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| CN 00133690 CN1102402C (en) | 2000-12-04 | 2000-12-04 | Chinese herbal granule for curing headache and its preparing method |
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| CN 00133690 CN1102402C (en) | 2000-12-04 | 2000-12-04 | Chinese herbal granule for curing headache and its preparing method |
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| CN1311014A true CN1311014A (en) | 2001-09-05 |
| CN1102402C CN1102402C (en) | 2003-03-05 |
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| CN 00133690 Expired - Fee Related CN1102402C (en) | 2000-12-04 | 2000-12-04 | Chinese herbal granule for curing headache and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178751A (en) * | 2011-04-26 | 2011-09-14 | 北京天力正元医药技术开发有限公司 | Brain clearing and pain relieving preparation |
| CN105213996A (en) * | 2015-11-06 | 2016-01-06 | 青岛麦瑞特医药技术有限公司 | A kind of pharmaceutical composition for the treatment of cerebral vasospasm headache |
-
2000
- 2000-12-04 CN CN 00133690 patent/CN1102402C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178751A (en) * | 2011-04-26 | 2011-09-14 | 北京天力正元医药技术开发有限公司 | Brain clearing and pain relieving preparation |
| CN102178751B (en) * | 2011-04-26 | 2013-04-10 | 北京天力正元医药技术开发有限公司 | Brain clearing and pain relieving preparation |
| CN105213996A (en) * | 2015-11-06 | 2016-01-06 | 青岛麦瑞特医药技术有限公司 | A kind of pharmaceutical composition for the treatment of cerebral vasospasm headache |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1102402C (en) | 2003-03-05 |
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