CN1310026A - Medical adhesive high molecular material and its preparation - Google Patents

Medical adhesive high molecular material and its preparation Download PDF

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Publication number
CN1310026A
CN1310026A CN 00111732 CN00111732A CN1310026A CN 1310026 A CN1310026 A CN 1310026A CN 00111732 CN00111732 CN 00111732 CN 00111732 A CN00111732 A CN 00111732A CN 1310026 A CN1310026 A CN 1310026A
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medical
material
amount
adhesive fixing
polymer
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CN 00111732
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Chinese (zh)
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宋治中
侯关荣
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宋治中
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Abstract

The medical material is prepared with thermoplastic polymer EVA resin, modifier MBS, additive dibutyl phthalate, etc. in certain proportion, and through heating, kneading, plasticizing, rolling pressing and drilling. It has proper plasticizing temperature and high reliability, and may be used in settling fracture and artificial limb sleeve and in protection after surgical operation.

Description

医用高分子自粘固定材料及其制造方法 Medical polymer adhesive fixing material and manufacturing method thereof

本发明涉及一种用于骨折病人固定骨折部位的可塑性固定材料,尤其涉及一种医用高分子自粘固定材料。 The present invention relates to a thermoplastic material which is fixed fracture patients for fracture fixation, in particular, it relates to a polymer material for medical self-adhesive fixing.

目前,绝大部分医院对骨折病人实施临时外固定和康复期保护时均采用传统的石膏固定法,这种方法虽能起到固定骨折部位的效果,但由于石膏材料笨重而给病人带来不便,又因为石膏不透气,从而造成病人患处皮肤红肿。 Both traditional plaster fixation Currently, the vast majority of hospitals implement temporary external fixation for protection and rehabilitation of fracture patients, although this method can play the effect of fixing the fracture site, but because of heavy plaster material and inconvenience to the patient , and because gypsum airtight, resulting in patients affected area of ​​skin redness. 为了解决固定骨折病人骨折部位的材料问题,日本、中国、英国也先后研制了各种固定材料,但有的材料热变形温度太低,容易变形,有的价格太昂贵,不适宜中国民众消费。 In order to solve the problem fixed patient material fracture site of fracture, Japan, China, the United Kingdom has also developed a variety of fixed materials, but some material is heat distortion temperature is too low, easily deformed, some prices are too expensive, not suitable for Chinese people consume.

本发明的目的就是为了克服上述现有技术存在的缺陷而提供一种材料来源广、成本低、制作简单、可塑温度适宜、使用可靠的医用高分子自粘固定材料及其制造方法。 The object of the present invention is to overcome the drawbacks existing in the prior art and to provide a source of material wide, low cost, simple manufacture, plastic suitable temperature, the use of reliable self-adhesive fixing of medical polymer materials and manufacturing method.

本发明的目的可以通过以下方案来实现:一种医用高分子自粘固定材料,它包括热塑性聚合物、改性剂和添加剂,所述的热塑性聚合物为EVA(乙烯-醋酸乙烯),其含量为50~95%(重量);所述的改性剂选自MBS(甲基丙烯酸甲酯-丁二烯-苯乙烯共聚物)、氯化聚乙烯、松香树脂、聚酰胺树脂、丁晴橡胶、丙烯酸树脂、医用压敏胶原料中的任意一种或几种,其含量为3~25%(重量);所述的添加剂包括增塑剂、润滑剂、着色剂,其含量为2~20%(重量)。 The object of the present invention can be achieved by the following solutions: A self-adhesive fixing polymer medical material, which comprises a thermoplastic polymer, modifier and additives, the thermoplastic polymer is an EVA (ethylene - vinyl acetate), in an amount 50 to 95% (by weight); said modifier is selected from MBS (methyl methacrylate - butadiene - styrene copolymer), chlorinated polyethylene, rosin resin, a polyamide resin, nitrile rubber , an acrylic resin, a medical pressure-sensitive material of any one or more, in an amount of 3 to 25% (by weight); the additives include a plasticizer, a lubricant, a colorant, in an amount of 2 to 20 %(weight).

所述的添加剂还包括填料,其含量为0-5%(重量)。 Said additive further comprises a filler in an amount (by weight) 0-5%.

所述的添加剂中的增塑剂选自邻苯二甲酸二丁酯、邻苯二甲酸二辛酸、丁二酸二丁酯、磷酸三辛酯、磷酸-苯二辛酯、己二酸二辛酯及环氧大豆油原料中的任意一种或几种,润滑剂为石蜡,着色剂为无机或有机颜料。 Said plasticizer additive is selected from dibutyl phthalate, dibutyl phthalate, caprylic acid, succinic acid, dibutyl phosphate, trioctyl phosphate - phenyl dioctyl adipate, dioctyl any one or more esters and epoxidized soybean oil feedstock, paraffin wax lubricant, a coloring agent is an inorganic or organic pigments.

所述的填料为碳酸钙、滑石粉或云母粉。 Said filler is calcium carbonate, talc or mica.

一种医用高分子自粘固定材料的制造方法,它包括以下工艺步骤: A method of manufacturing a self-adhesive fixing of medical polymer materials, comprising the following process steps:

(A). (A). 将各物料按权利要求1所述的比例在加温捏合机中混合均匀;(B). The proportion of each material according to claim 1 in a warmed kneader and mixed uniformly; (B). 将上述物料在辊机或密炼机或挤出机中塑炼,塑化温度为100℃~180℃;(C). The above materials were masticated in a Banbury mixer or roll mill or extruder, plasticizing temperature of 100 ℃ ~ 180 ℃; (C). 将已塑化的物料在压延机上压延成0.1mm~10mm的片材;(D). The plasticized material of the calender on a sheet of 0.1mm ~ 10mm; (D). 将上述片材打孔,并用成型切割机切割成所需的大小和形状。 The punching of the sheet, and cut into a desired size and shape by molding cutter.

与现有技术相比,由于本发明采用了以上的方法,使制得的固定材料具有低温可逆热塑性自粘的效果,该材料在-10℃~45℃的温度时为刚性片材,弯曲强度20Pa~70MPa,抗拉强度为20MPa~60MPa,若将其加热到60℃~80℃,材料软化自粘,可塑成所需形状。 Compared with the prior art, since the present invention employs the above method so that the resulting material has low temperature fixing effect reversible thermoplastic adhesive, the material at a temperature of -10 ℃ ~ 45 ℃ of rigid sheet, bending strength 20Pa ~ 70MPa, a tensile strength of 20MPa ~ 60MPa, if heated to 60 ℃ ~ 80 ℃, self-adhesive material is softened, may be molded into the desired shape. 本发明涉及的固定材料用于替代石膏对骨折部位的固定和康复保护,具有使用方便、透气、重量轻、病人感觉舒适、医生操作简单等优点。 The present invention relates to a fixing material for fixing and rehabilitation replace plaster of the fracture site protection, easy to use, breathable, lightweight, patient comfort, doctors simple operation.

下面结合实施例,对本发明作进一步说明。 Below in connection with embodiments of the present invention will be further described.

实施例1取EVA70公斤、医用压敏胶10公斤、MBS 8公斤、松香树脂7公斤、着色剂1公斤、石蜡1公斤、邻苯二甲酸二辛酯3公斤,将以上物料在捏合机中加热捏合后在挤出机中塑炼挤出,塑炼温度为150℃,然后在压延机上压延成2~3mm的片材,并在片材上以每平方厘米3~5个的密度打直径为2~3mm的小孔。 EXAMPLE 1 EVA70 kg, 10 kg medical pressure-sensitive, MBS 8 kg, 7 kg rosin resin, a coloring agent 1 kg, 1 kg of paraffin, dioctyl phthalate, 3 kg, the above materials are heated kneader after kneading in an extruder plasticating extruder, mastication temperature is 150 deg.] C, and then calendered on a calender sheets of 2 ~ 3mm, and at a density of 3 to 5 cm of diameter in the play of the sheet 2 ~ 3mm holes. 如此得到的产品可用于手臂和腿部骨折病人的手臂和腿部的固定。 The product thus obtained can be used to fix the arm and leg fractures of the arms and legs of patients. 当其加热到60℃~75℃即可软化,并通过包裹被固定物后首尾搭接自粘,冷却后固定,病人康复后,将固定材料加热到50℃即可解除固定。 To soften when heated to 60 ℃ ~ 75 ℃, end to end and are overlapped by wrapping adhesive after fixation, cooled fixed, patient recovery, the material is heat-fixed to unfixed to 50 deg.] C.

实施例2取EVA60公斤、丙烯酸树脂8公斤、MBS 7公斤、聚酰胺树脂5公斤、有机白1公斤、石蜡2公斤、邻苯二甲酸二丁酯6公斤,邻苯二甲酸二辛酯6公斤,碳酸钙5公斤,将以上物料在捏合机中加热捏合后在挤出机中塑炼挤出,塑炼强度为180℃,然后在压延机上压延成5mm的片材,并在片材上均匀地打上小孔。 EXAMPLE 2 EVA60 kg, 8 kg of acrylic resin, MBS 7 kg, 5 kg of the polyamide resin, the organic white 1 kg, 2 kg of paraffin wax, dibutyl phthalate 6 kg, dioctyl phthalate 6 kg , 5 kg calcium carbonate, kneading the above material is heated in a plasticating extruder at an extrusion kneader, masticated strength of 180 ℃, and then calendered on a calender 5mm sheet, and uniformly on the sheet the marked holes. 由此得到的产品可用于锁骨和颈部骨折病人的肩和颈部的固定。 The product thus obtained can be used for fixing the shoulder and neck and clavicle neck fracture patients. 所述的产品两边还可以向外延伸两条搭接边,当被固定物较大时,可以通过两条搭接边搭接自粘。 The product may also extend outwardly on both sides of two overlapped edges, to be fixed when the larger, self-adhesive by two overlapping edges can overlap.

实施例3取EVA90公斤、MBS 7公斤、无机黄0.5公斤、石蜡1公斤、磷酸三辛酯1.5公斤,将以上物料在捏合机中加热捏合后在密炼机中塑炼,塑炼温度为100℃,然后在压延机上压延成0.5mm的片材,并在片材上均匀地打上小孔。 Example 3 taken EVA90 kg, MBS 7 kg, inorganic yellow 0.5 kg, 1 kg paraffin, trioctyl phosphate 1.5 kg, the material was heated above kneaded in a kneader mixer in the mixing of plastic, a temperature of 100 masticated ℃, then rolled into a sheet of 0.5mm in the calender, and uniformly marked apertures on the sheet. 由此得到的产品可用于手指骨折病人的手指部固定。 The product thus obtained can be used for finger portion fixed finger fracture patients. 固定方法与实施例1相同。 Fixing method same as in Example 1.

此外,本发明固定材料还可用于假肢套的长期固定,或用于手术后的保护等。 Further, the present invention may further fixing material for long-term fixed prosthesis sleeve or the like for protection after surgery.

Claims (5)

1. 1. 一种医用高分子自粘固定材料,它包括热塑性聚合物、改性剂和添加剂,其特征在于:所述的热塑性聚合物为EVA(乙烯-醋酸乙烯),其含量为50~95%(重量);所述的改性剂选自MBS(甲基丙烯酸甲酯-丁二烯-苯乙烯共聚物)、氯化聚乙烯、松香树脂、聚酰胺树脂、丁晴橡胶、丙烯酸树脂、医用压敏胶原料中的任意一种或几种,其含量为3~25%(重量);所述的添加剂包括增塑剂、润滑剂、着色剂,其含量为2~20%(重量)。 A medical adhesive fixing polymer material comprising a thermoplastic polymer, modifier and additives, characterized in that: said thermoplastic polymer is EVA (ethylene - vinyl acetate) in an amount of 50 to 95% (wt. ); said modifier is selected from MBS (methyl methacrylate - butadiene - styrene copolymer), chlorinated polyethylene, rosin resin, a polyamide resin, nitrile rubber, an acrylic resin, a medical pressure-sensitive any one or more of a collagen compound in an amount of 3 to 25% (by weight); the additives include a plasticizer, a lubricant, a colorant, in an amount (by weight) 2% to 20%.
2. 2. 根据权利要求1所述的一种医用高分子自粘固定材料,其特征在于:所述的添加剂还包括填料,其含量为0-5%(重量)。 A medical polymer adhesive fixing material according to claim 1, wherein: said additive further comprises a filler in an amount (by weight) 0-5%.
3. 3. 根据权利要求1所述的一种医用高分子自粘固定材料,其特征在于:所述的添加剂中的增塑剂选自邻苯二甲酸二丁酯、邻苯二甲酸二辛酸、丁二酸二丁酯、磷酸三辛酯、磷酸一苯二辛酯、己二酸二辛酯及环氧大豆油原料中的任意一种或几种,润滑剂为石蜡,着色剂为无机或有机颜料。 According to one medical polymer adhesive fixing material according to claim 1, wherein: said additive is a plasticizer selected from dibutyl phthalate, dibutyl phthalate, octanoic acid, succinic acid dibutyl, trioctyl phosphate, dioctyl phenyl phosphate, dioctyl adipate, epoxidized soybean oil and feed any one or several of the lubricant is a paraffin, a coloring agent is an inorganic or organic pigments.
4. 4. 根据权利要求2所述的一种医用高分子自粘固定材料,其特征在于:所述的填料为碳酸钙、滑石粉或云母粉。 According to one medical polymer adhesive fixing material according to claim 2, wherein: said filler is calcium carbonate, talc or mica.
5. 5. 一种医用高分子自粘固定材料的制造方法,其特征在于:它包括以下工艺步骤:(A). A method of manufacturing a self-adhesive fixing of medical polymer material, characterized in that: it comprises the following process steps: (A). 将各物料按权利要求1所述的比例在加温捏合机中混合均匀;(B). The proportion of each material according to claim 1 in a warmed kneader and mixed uniformly; (B). 将上述物料在辊机或密炼机或挤出机中塑炼,塑化温度为100℃~180℃;(C). The above materials were masticated in a Banbury mixer or roll mill or extruder, plasticizing temperature of 100 ℃ ~ 180 ℃; (C). 将已塑化的物料在压延机上压延成0.1mm~10mm的片材;(D). The plasticized material of the calender on a sheet of 0.1mm ~ 10mm; (D). 将上述片材打孔,并用成型切割机切割成所需的大小和形状,即得产品。 The punching of the sheet, and the size and shape of the desired shaped cutter is cut, the product is obtained.
CN 00111732 2000-02-24 2000-02-24 Medical adhesive high molecular material and its preparation CN1310026A (en)

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103301511A (en) * 2013-06-20 2013-09-18 王惠 Complex implant for fixing human skeletons
CN103432622A (en) * 2005-02-22 2013-12-11 德普伊新特斯产品有限责任公司 Methods, materials and apparatus for treating bone and other tissue
CN104610645A (en) * 2015-01-27 2015-05-13 新疆科蓝双谊医疗科技股份有限公司 Low-temperature high-strength thermoplastic board, fiber fabric thermoplastic board, and preparation methods of low-temperature high-strength thermoplastic board and fiber fabric thermoplastic board
US9186194B2 (en) 2003-03-14 2015-11-17 DePuy Synthes Products, Inc. Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US9259696B2 (en) 2005-11-22 2016-02-16 DePuy Synthes Products, Inc. Mixing apparatus having central and planetary mixing elements
US9381024B2 (en) 2005-07-31 2016-07-05 DePuy Synthes Products, Inc. Marked tools
US9504508B2 (en) 2003-06-17 2016-11-29 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
US9642932B2 (en) 2006-09-14 2017-05-09 DePuy Synthes Products, Inc. Bone cement and methods of use thereof
US9750840B2 (en) 2004-03-21 2017-09-05 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
US9839460B2 (en) 2003-03-31 2017-12-12 DePuy Synthes Products, Inc. Remotely-activated vertebroplasty injection device
US9918767B2 (en) 2005-08-01 2018-03-20 DePuy Synthes Products, Inc. Temperature control system
US10111697B2 (en) 2003-09-26 2018-10-30 DePuy Synthes Products, Inc. Device for delivering viscous material

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9186194B2 (en) 2003-03-14 2015-11-17 DePuy Synthes Products, Inc. Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US9839460B2 (en) 2003-03-31 2017-12-12 DePuy Synthes Products, Inc. Remotely-activated vertebroplasty injection device
US10039585B2 (en) 2003-06-17 2018-08-07 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
US9504508B2 (en) 2003-06-17 2016-11-29 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
US10111697B2 (en) 2003-09-26 2018-10-30 DePuy Synthes Products, Inc. Device for delivering viscous material
US9750840B2 (en) 2004-03-21 2017-09-05 DePuy Synthes Products, Inc. Methods, materials and apparatus for treating bone and other tissue
CN103432622A (en) * 2005-02-22 2013-12-11 德普伊新特斯产品有限责任公司 Methods, materials and apparatus for treating bone and other tissue
US9381024B2 (en) 2005-07-31 2016-07-05 DePuy Synthes Products, Inc. Marked tools
US9918767B2 (en) 2005-08-01 2018-03-20 DePuy Synthes Products, Inc. Temperature control system
US9259696B2 (en) 2005-11-22 2016-02-16 DePuy Synthes Products, Inc. Mixing apparatus having central and planetary mixing elements
US9642932B2 (en) 2006-09-14 2017-05-09 DePuy Synthes Products, Inc. Bone cement and methods of use thereof
CN103301511A (en) * 2013-06-20 2013-09-18 王惠 Complex implant for fixing human skeletons
WO2014201763A1 (en) * 2013-06-20 2014-12-24 Wang Hui Composite implant for fixing human skeleton
CN104610645A (en) * 2015-01-27 2015-05-13 新疆科蓝双谊医疗科技股份有限公司 Low-temperature high-strength thermoplastic board, fiber fabric thermoplastic board, and preparation methods of low-temperature high-strength thermoplastic board and fiber fabric thermoplastic board

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