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口服给药后能够长时间释放曲美他嗪的基质片
CN1302663A
China
Description
translated from
| 化合物 | 含量(毫克) | ||
| F1 | F2 | F3 | |
| 曲美他嗪二盐酸盐 | 60 | 30 | 35 |
| 羟丙基甲基纤维素 | 112 | 74 | 74 |
| 聚乙烯吡咯烷酮 | 13.3 | 8.7 | 8.7 |
| 磷酸氢钙二水合物 | 92 | 85.9 | 80.9 |
| 硬脂酸镁 | 2.2 | 1 | 1 |
| 无水胶态二氧化硅 | 0.5 | 0.4 | 0.4 |
| 片剂总重量 | 280 | 200 | 200 |
| 化合物 | 含量(毫克) | |
| F4 | F5 | |
| 曲美他嗪二盐酸盐 | 35 | 35 |
| 羟丙基甲基纤维素 | 54 | 94 |
| 聚乙烯吡咯烷酮 | 10.1 | 7.3 |
| 磷酸氢钙二水合物 | 99.5 | 62.3 |
| 硬脂酸镁 | 1 | 1 |
| 无水胶态二氧化硅 | 0.4 | 0.4 |
| 片剂总重量 | 200 | 200 |
| 时间(小时) | 释放的化合物的百分数(％) | |
| F4 | F5 | |
| 1 | 41 | 38 |
| 2 | 59 | 59 |
| 3 | 80 | 77 |
| 4 | 97 | 96 |
| 化合物 | 含量(毫克) | ||
| F3 | F6 | F7 | |
| 曲美他嗪二盐酸盐 | 35 | 35 | 35 |
| 羟丙基甲基纤维素4000 cP | 74 | - | - |
| 羟丙基甲基纤维素100 cP | - | - | 74 |
| 羟丙基甲基纤维素100 000 cP | - | 74 | - |
| 聚乙烯吡咯烷酮 | 8.7 | 8.7 | 8.7 |
| 磷酸氢钙二水合物 | 80.9 | 80.9 | 80.9 |
| 硬脂酸镁 | 1 | 1 | 1 |
| 无水胶态二氧化硅 | 0.4 | 0.4 | 0.4 |
| 时间 | 释放的化合物的百分数(％) | ||
| F3 | F6 | F7 | |
| 1 | 43 | 41 | 40 |
| 2 | 62 | 59 | 60 |
| 3 | 86 | 83 | 83 |
| 4 | 105 | 102 | 100 |