CN1295486A - Metered dose infusion pump and method - Google Patents

Metered dose infusion pump and method Download PDF

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Publication number
CN1295486A
CN1295486A CN 99804498 CN99804498A CN1295486A CN 1295486 A CN1295486 A CN 1295486A CN 99804498 CN99804498 CN 99804498 CN 99804498 A CN99804498 A CN 99804498A CN 1295486 A CN1295486 A CN 1295486A
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metered
dose
infusion
pump
method
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CN 99804498
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Chinese (zh)
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史蒂芬·O·罗斯
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巴克斯特国际公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps

Abstract

一种管内给药组件(14)包括一轴向运动的往复式泵压头(98),其具有一泵压头入口(110)和泵压头出口(112)。 An in-pipe assembly administration (14) comprises a reciprocating pump head axial movement (98), having a pump head inlet (110) and a pump head outlet (112). 输入管(96)具有安装在泵压头入口(110)的第一端和适于与一贮液器相连的第二端。 Inlet tube (96) having a first end and a second end adapted to be connected to a reservoir mounted on the pump head inlet (110). 一输出管(100)具有与泵压头出口(112)相连的第一端及适于与患者血管液态相连的第二端。 An outlet pipe (100) having a first end and a second end adapted to be connected to the patient vascular liquid pump head outlet (112) is connected. 轴向运动的往复式泵压头(98)的泵压头入口(110)和泵压头出口(118)沿泵压头(98)轴向设置。 Reciprocating axial movement of the pump head (98) of the pump head inlet (110) and a pump head outlet (118) disposed along an axial pump head (98). 管内注液泵(80)装配有给药组件(14)且包括一可控制地与泵压头(98)相连的线性往复驱动装置。 Injection pump of the inner tube (80) equipped with a dosing assembly (14) comprises a controllable manner and with the pump head (98) connected to the linear reciprocating drive means. 贮液器可采用注射器(94),通过在注射器出口(108)处产生负压力从注射器泵送液体。 The reservoir may employ a syringe (94), the liquid pumped from the syringe through the negative pressure is generated in the injector outlet (108) at. 一种液体管内注射的方法使用了给药组件(14)和线性往复驱动装置(132)。 A method in a liquid injection tube using a dosing assembly (14) and a linear reciprocating drive (132).

Description

定量注液泵及其方法 The method of quantitative injection pump and

技术领域 FIELD

本发明涉及注液泵,更特别涉及一种定量注液泵,一种用于注液泵的给药组件及一种用于对患者进行血管内注射时输送规定量药液的方法。 The present invention relates to the injection pump, and more particularly relates to a quantitative injection pump, the injection pump assembly A drug delivery and a method for transporting a predetermined amount of liquid injection to a patient when used in the blood vessel.

为了确保具有潜在危险性药物的准确用量,已存在制造更精密复杂泵送设备的趋势。 To ensure accurate dosage of potentially dangerous drugs, trends in manufacturing more sophisticated pumping equipment already exists. 虽然,目前在技术上已能够成功提高泵送精度,但是仍存在一些严重的缺陷。 Although it is technically have been able to successfully increase the accuracy of pumping, but there are still some serious flaws. 更重要的是,许多这些泵均依赖于非常精密和复杂的驱动设备和泵压头结构,因此增加了泵的复杂性和成本。 More importantly, many of these pumps rely on very sophisticated and complex device driver and pump head structure, thereby increasing the complexity and cost of the pump. 例如,虽然已经花费了很大的努力来设计更精密的蠕动泵,这种泵依靠将一低成本Ⅳ管作为一次性泵腔,但是,力图增加精确性必然会大大导致泵结构的复杂化及成本的提高。 For example, although a great deal of effort has been spent to design more sophisticated peristaltic pump, the pump will rely on a low-cost Ⅳ tube as a disposable pump chamber, however, sought to greatly increase the accuracy will inevitably lead to complicated structures and pump higher costs. 利用一次性盒体作为泵压头的泵的生产者也会遇到要求降低制造成本,提高可靠性和采用精密盒体的问题。 As the pump head of the pump will encounter in claim producers to reduce manufacturing costs, improve reliability and precision problems using a disposable cartridge by cartridge.

本发明的目的在于克服上述一个或多个问题。 Object of the present invention is to overcome one or more of the problems.

本发明的第一个方面提供了一种管内给药组件,其包括:一轴向运动的往复式泵压头,该泵压头具有一泵压头入口和一泵压头出口。 A first aspect of the present invention provides an in-pipe assembly administration, comprising: an axially reciprocating pump head movement, the pump head having a pump head inlet and a pump head outlet. 一输入管具有安装在泵压头入口的第一端及和适于与一贮液器相连的第二端。 An input terminal and a first and a second end adapted to connected to a reservoir mounted in the pump head having an inlet tube. 一输出管具有与泵压头出口相连的第一端及一适于与一患者血管液态相连的第二端。 An outlet tube having a first end and a second end adapted for connection with a liquid vessel of a patient connected to the pump head outlet. 往复式泵压头的泵压头入口和泵压头出口最好沿泵压头轴向设置。 A reciprocating pump head pump head inlet and a pump head outlet is preferably disposed axially along the pump head. 给药组件可包括一与输入管第二端相连的贮液器,同时贮液器包括一注射器。 Administration assembly may include a liquid reservoir connected to a second end of the inlet pipe, while the reservoir comprises a syringe. 在一最佳实施例中,轴向运动的往复式泵压头包括一可滑动容纳在液缸内的活塞,所述活塞在液缸内的排放位置和再装填位置之间移动,以使液流抽入泵压头入口,并从泵压头出口排出。 In a preferred embodiment, the axial movement of the reciprocating pump head comprises a slidably movable between a discharge position received in the cylinder and liquid in the fluid refill position of the piston within the cylinder, the piston, so that fluid flow into the pump head inlet and discharged from the pump head outlet. 一控制阀与液缸液态相连,以当活塞从排放位置移动至再装填位置时,促使液流仅从泵压头入口进入液缸,且当活塞从再装填位置移动至排放位置时,促使液流仅从泵压头出口排出。 A control valve connected to the liquid of the liquid cylinder, to when the piston moves from the discharge position to the refill position to promote the flow only from the pump inlet into the cylinder head, and when the piston is moved from the refill position to a discharge position, causes the liquid stream is discharged only from the pump head outlet. 一连杆装配在活塞上,用于在排放位置和再装填位置之间移动活塞,连杆与一线性往复驱动装置接合。 A rod mounted on the piston for moving the piston, connecting rod and a linear reciprocating drive means engagement between the discharge position and refill position.

本发明的第二方面提供了一种管内注液泵,其包括:一轴向运动的往复式泵压头,该泵压头具有一泵压头入口和一泵压头出口。 A second aspect of the present invention provides an in-pipe injection pump, comprising: an axially reciprocating pump head movement, the pump head having a pump head inlet and a pump head outlet. 一壳体包括一容纳泵压头的泵压头接收器。 Comprising a pump housing accommodating a pump head ram receiver. 一贮液器通过一输入管与泵入口液态相连。 A liquid inlet connected to the reservoir via a supply line with a pump. 一输出管具有与泵压头出口液态相连的第一端及适于与一患者血管液态相连的第二端。 An outlet tube having a first end and a second end connected to the liquid outlet of the pump head is adapted to a patient connected to a liquid vessel. 一在壳体内的线性往复驱动装置可控制地与泵压头相连,以驱动泵压头。 A linear reciprocating drive within the housing, the control means may be connected to the pump head to drive the pump head. 贮液器最好也设置在壳体内。 The reservoir is also preferably disposed within the housing. 在另一种最佳结构中,一控制器可控制地与往复线性驱动装置相连,用于控制泵压头的预定程序操作,而给出一理想的输出曲线。 In another preferred arrangement, a controller controllably connected with the reciprocating linear drive means, for a predetermined program to control the operation of the pump head, to give a desired output curve. 在另一最佳实施例中,轴向运动的往复式泵压头包括一可滑动容纳在液缸中的活塞,所述活塞可在液缸内的排放位置和再装填位置之间轴向运动,以将液体吸入泵压头入口并从泵压头出口排出液体。 In another preferred embodiment, the axial movement of the reciprocating pump head includes a cylinder slidably received in the piston axially movable between a discharge position and a fluid refill position of the cylinder to the liquid suction inlet of the pump head outlet and the liquid is discharged from the pump head. 当活塞从排放位置移动至再装填位置时,一与液缸液态相连的控制阀使液流仅从泵压头入口进入液缸,且当活塞从再装填位置移动至排放位置时,使液流仅从泵压头出口排出。 When the piston to the recharged position from the discharge position, a control valve connected to the hydraulic cylinder so that a liquid flow only from the pump inlet into the cylinder head, and when the piston is moved from the refill position to the discharge position, so that the flow only discharge pump head outlet. 一装配至活塞的连杆在排放位置和再装填位置之间移动活塞。 A piston fitted to move the piston rod between the discharge position and the refill position. 所述连杆与一线性往复驱动装置接合。 The link with the linear reciprocating drive means engagement. 线性往复驱动装置最好包括一具有一旋转驱动轴的电动机及一可控制地与驱动轴和轴向运动的往复式泵压头相连的线性转换器的旋转机构,用以驱动泵压头。 Preferably the linear reciprocating drive means comprises a rotating mechanism having a rotary drive shaft of the motor and a reciprocating pump may be controlled with the head drive shaft and the axial movement of the linear transducer connected to drive the pump head. 线性转换器的旋转机构可包括一偏心固定于电动机驱动轴上的凸轮及一受偏压接触凸轮边缘的凸轮随动件。 Rotary linear converter mechanism may comprise an eccentric cam fixed to a drive shaft on the motor and the cam is biased by a contact with the cam follower edge. 当凸轮转动时,与轴向运动的往复式泵压头相连的凸轮随动件作线性往复运动。 As the cam rotates, the cam and the axial movement of the reciprocating pump head connected to the follower member linearly reciprocated. 一与电动机相连的编码器与控制器电耦合,以便能够精确监控泵的输出。 An encoder coupled to the motor and connected to a controller, to be able to accurately monitor the output of the pump.

本发明的第三方面提供了一种对患者进行管内注射药液的方法,该方法包括设置一轴向运动的往复式泵压头,该泵压头具有一泵压头入口和一泵压头出口并设有输入管和输出管。 A third aspect of the present invention provides a method of patient inner tube injects a drug solution, the method comprising setting a reciprocating pump head axial movement, the pump head having a pump head inlet and a pump head and an outlet provided with inlet and outlet tubes. 输入管的第一端与泵压头入口液态相连,且输入管的第二端与一贮液器液态相连。 A first end of the inlet tube connected to a liquid inlet of the pump head, and a second end connected to a reservoir of liquid feed tube. 输出管的第一端与泵压头出口液态相连,且第二端与患者的血管液态相连。 A first end of the pump head outlet connected to the liquid outlet tube, and a second end connected to a liquid vessel of the patient. 往复线性驱动装置与泵压头可控制地相连且被操纵使液体从贮液器排放至患者血管,在该方法的一个最佳实施例中,轴向运动的往复式泵压头为包括一雾化器的鼻腔定量喷雾泵机构,且该方法还包括阻塞所述雾化器。 A reciprocating linear drive with the pump head may be manipulated and controllably connected to the liquid discharged from the reservoir to the patient's vessel, in a preferred embodiment of the method, the axial movement of the reciprocating pump head comprises a fog of quantitative nasal spray pump mechanism of the device, and the method further comprises blocking the atomizer.

本发明的管内给药组件使用了一重量大大减轻的轴向运动的往复式泵压头,该泵压头多年来已在千万个手动往复式鼻腔定量喷雾泵中用于对患者鼻腔供给悬浮微粒药物。 Administration of the inner tube assembly of the present invention uses a reciprocating pump head greatly reduce the weight of the axial movement of the pump head has been used for many years in ten million manual reciprocating nasal metered pump supplying the suspension to a patient nasal particulate drugs. 结果,可购得的泵压头成品数量实际上是极大的,因此可大大降低了成本。 As a result, the number of pump pressure head available is actually finished great, thus greatly reducing the cost. 另外,在大量场合下,简单的泵压头机构已能保证其精度和可靠性。 Further, in the case where a large number of simple pump head mechanism has been able to ensure its accuracy and reliability. 由于成本较低,因此给药组件易于采用一次性产品,从而进一步加强了卫生和安全性。 Due to the low cost, ease of assembly and therefore administered using disposable products, thus further strengthening the health and security. 泵压头所具有的极轻重量有助其与流动性注液泵一起使用。 Pump head has a very light weight facilitate use with mobility injection pump. 因为泵压头需要简单的线性动作来产生精确的输出,因此,大量线性往复式驱动装置适于与装有轴向运动的往复式泵压头的注液泵一起使用。 Because the pump head requires simple linear operation to generate accurate output, and therefore, a large number of linear reciprocating drive apparatus adapted for use with the injection pump reciprocating pump head with an axial movement. 使用了所述泵压头的注液泵能够提供大致连续的液体流或快速注射。 Use of the injection pump of the pump head can provide substantially continuous liquid flow, or bolus injection. 并且,它还能够在整个大量的泵压头动作期间输送非常准确的流体量。 Further, it can deliver a very precise amount of fluid in a large number of pump head during the entire operation.

图1为用于说明本发明管内注液泵的示意图;图2为利用了一注射贮液器的本发明管内注液泵的一个实施例的透视图;图3为图2中管内注液泵的泵送机构和给药组件的透视图;图4为用于本发明的管内注液泵的典型轴向往复泵头的分解视图。 Figure 1 is a schematic view of an inner tube for the injection pump of the present invention is described; FIG. 2 is a perspective view of one embodiment using the embodiment of the present invention, the inner tube of the reservoir of an injection of the injection pump; FIG. 3 is a view of the inner tube 2 in the injection pump perspective view of the pumping mechanism and administering assembly; 4 axially reciprocating pump head is typically used in the present invention, the inner tube of the injection pump is an exploded view of FIG.

给药组件14包括一泵压头16,该泵压头通过一输入管20、由一贮液器18接收液体且经一输出管22将液体输送至与患者血管液态相连的一患者连接体24。 Dosing pump assembly 14 includes a head 16, the pump head via an input pipe 20 by a receiver 18 and a liquid reservoir via a liquid outlet pipe 22 is connected to a patient delivery vessel to a patient is connected to the liquid body 24 . 患者连接体可以是本领域已知的针,导管或任意其它适合的装置。 Patients linker known in the art may be a needle, catheter or any other suitable means. 一排气过滤器26最好与输出管液态相连,以便在将液体导入至患者之前,排出任意可能已导入液体内的气泡。 An exhaust filter 26 is preferably connected to a liquid outlet tube, so that liquid introduced into the patient prior to discharge any possible air bubbles in the liquid have been introduced. 泵压头16最好包括一轴向运动的往复式泵压头,其带有一与输入管20液态相连的泵压头入口28和一与输出管22液态相连的泵压头出口30。 The pump head 16 preferably comprises a reciprocating pump head axial movement, which is connected with the pump head 20 and a liquid inlet tube 28 and the pump head inlet 22 and a liquid outlet pipe connected to the outlet 30. 如图1所示,泵压头入口28和出口30最好是同轴的。 1, the pump head inlet 28 and outlet 30 are preferably coaxial. 泵压头16最好包括一成品鼻腔定量喷雾泵机构,该机构已被改进来减活任何雾化器,以便空气不会经定量喷雾泵进入被泵送的液体。 The pump head 16 comprises a preferably quantitative finished nasal spray pump mechanism that has been modified to deactivate any atomizer so that air does not enter the liquid is pumped via a metered pump. 在Haber等人的美国专利NO.5,433,191中披露了这种鼻腔定量喷雾泵,整个文献可在本申请中结合使用。 This is disclosed a metered nasal pump in Haber et al., U.S. Patent No. NO.5,433,191, the entire document may be used in combination in the present application. 合适的鼻腔定量喷雾泵机构的其它例子包括德国Pfeiffer制造的装置,其包括型号no.10358BSK 5635(100μl)及型号no.6958.59002/600(50μl)。 Other examples of suitable nasal metered pump mechanism comprises a means for producing Pfeiffer of Germany, including model no.10358BSK 5635 (100μl) and model no.6958.59002 / 600 (50μl). 这些典型泵压头中的每一个均具有同轴的泵入口和出口,且被轴向往复驱动。 The pump head is typically each have coaxial pump inlets and outlets and is axially reciprocated.

泵体12包括一用于封装泵中电子部件及驱动装置的壳体36。 A pump 12 includes a pump housing enclosing the electronic component and the drive unit 36. 在壳体中设置一用于控制泵驱动装置工作的控制器38。 Disposed in the housing for controlling a pump drive controller 38 operating. 控制器38最好包括具有选择功能的可编程微信息处理器和存储器,以便控制并监测泵送机构的工作且控制用于患者的药液的选择输送曲线。 The controller 38 preferably includes a programmable micro-processor and a memory having information selection function, in order to control and monitoring and controlling the pumping mechanism to select delivery profile of liquid to a patient. 另外,如本领域技术人员所理解的那样,多种逻辑电路能够实现控制器的功能,不过与微信息处理器和配套的存储器一样,这些电路不具有重设程序的优点。 Further, as those skilled in the art will appreciate, a variety of logic circuits to perform functions of the controller, but as the micro processor and associated memory information, these circuits do not have the advantage of the reset process.

控制器38通过连接器40被连接至包括一编码器44的驱动装置42,编码器44本身通过连接器46连接至控制器。 Controller 38 through the connector 40 is connected to the drive means 44 comprises an encoder 42, encoder 44 itself connected to the controller 46 via the connector. 驱动装置可采用任意用于对泵压头16提供线性往复驱动的适合驱动装置。 The device can be used to provide any pump head 16 for linear reciprocal drive means for driving. 编码器44的功能在于对控制器38提供一表示驱动周期的信号,因此泵压头起动来监控泵的输出。 Encoder function 44 to provide a signal representing the driving cycle of the controller 38, to monitor the output of the pump head of the pump started. 驱动装置42最好为一电动机且编码器为一霍尔传感器。 Drive means 42 is preferably an electric motor and the encoder is a Hall sensor. 在这一实施例中,电动机的驱动轴48与线性转换器50的转动机构相耦合,线性转换器50本身通过联动装置52可控制地与轴向运动的往复泵压头16相连,联动装置52可采用凸轮从动件或类似装置。 In this embodiment, the drive shaft of the motor 48 coupled to the rotation mechanism linear converter 50, 50 is connected by a linkage 52 itself may be controlled with a reciprocating axial movement of the pump ram linear converter 16, the linkage 52 The cam follower may be employed or the like. 另外,驱动装置42可以是能够直接对泵压头16施加线性往复运动的电动螺线管或气动缸。 Motor the driving device 42 may be capable of applying a linear reciprocating motion of the pump head 16 directly to the solenoid or pneumatic cylinder. 泵体12最好也包括一接收器53,其用于容纳泵压头16和给药组件14的其它部件并保持给药组件14与下文所述的泵驱动设备和传感器可控制地相连。 The pump body 12 also preferably includes a receiver 53 for receiving the other components of the pump 16 and the dosing head assembly 14 is connected and held administered assembly 14 may be controlled with the pump drive apparatus and sensors described below.

泵体12还包括多个传感器。 Body 12 further includes a plurality of sensors. 一位置传感器54通过连接器56与所述控制器相连,其用于对所述控制器发出说明泵压头16在接收器53内正确定位的信号。 A position sensor 54 connected to the controller 56 through a connector, for signals of the controller issues instructions pump head 16 is properly positioned within the receiver 53. 按程序设定所述控制器,以便如果未接收到信号,则会对使用者提供一适当的告警信号。 Programmed by the controller, so that if the signal is not received, the user will provide a suitable alarm signal.

一出口压力传感器58通过连接器60与所述控制器相连。 An outlet pressure sensor 58 is connected via connector 60 to the controller. 所述出口压力传感器可控制地与给药组件14的输出管22相连,用于检测在输出管22内部、表示下游堵塞的压力增量。 The outlet pressure sensor assembly can be controlled with the administration tube 22 is connected to the output 14, for detecting the internal pressure increment output tube 22, represents the downstream occlusion. 一入口压力传感器162通过连接器64被连接至所述控制器且可控制地与输入管20相连,以便探测在输入管20中表示缺少泵压头16上游流体的压力减少量,其可能在贮液器18排空时产生。 A pressure sensor 162 through the inlet connector 64 is connected to the controller and connected to the feed line 20 can be controlled so as to detect the pressure indicates a lack of fluid upstream of the pump 16 to reduce the amount of head pressure in supply line 20, which may be in the reservoir receiver 18 generates emptying. 控制器38通过连接器66被连接至电源68。 The controller 38 is connected to the power supply 68 via connector 66. 电源68可以采用电池或一包括合适交/直流转换器的标准交流输出端的接线。 A battery or power source 68 may be employed including a standard AC output terminal suitable AC / DC converter. 设置与电源相连的另一传感器来探测电源状态。 Another sensor is provided to detect a power supply connected to the power state. 所有传感器均经它们各自的连线将信号提供至控制器38。 All sensors via their respective connection 38 will signal to the controller. 正确设定控制器38的程序以接收并处理其接收的传感器信号。 Correct setting program controller 38 to receive and process the sensor signals it receives. 正确的影像或告警信号通过以连线72连接至所述控制器的显示器70被输送至使用者。 Correct video signal or an alarm display 72 is connected by wires to the controller 70 is delivered to the user. 除了显示告警信号以外,所述显示器还将有用信息,如泵的速率,泵送量,输送曲线等输送至泵的使用者。 In addition to displaying warning signals, the display of the user information will be useful, such as pump rate, volume pumped, delivery profile delivered to the pump and the like. 所述显示器可采用传统的液晶点阵显示器。 The display can be a conventional liquid crystal dot-matrix display. 用户输入端74通过连线76与所述控制器耦合。 The user input terminal 74 via line 76 coupled to the controller. 使用者通过所述输入端控制泵的操作。 Operation of the pump is controlled by the user input. 控制器38响应各种输入信号,从而控制泵送机构。 The controller 38 in response to various input signals, thereby controlling the pumping mechanism.

注液泵10可以被设计为一次性的,同时给药组件14被永久密封在壳体36内部。 Injection pump 10 may be designed to be disposable, simultaneous administration assembly 14 is permanently sealed within the housing 36. 显然,这一实施例无需使用位置传感器54。 Obviously, this embodiment without using a position sensor 54. 另一方面,泵体是可以重复使用的,而给药组件14则是一次性的。 On the other hand, the pump body is reusable, administered assembly 14 is disposable.

本发明中管内注液泵的注射器泵80的例子如图2所示。 Examples of the present invention, the inner tube of the injection pump of the syringe pump 80 shown in FIG. 注射器泵80具有一刚性壳体82,该壳体包括有一封闭泵机械部分和电子部分的外壳84。 Syringe pump 80 having a rigid housing 82, the housing comprises a closed pump housing 84 and the mechanical portion of the electronic parts. 在外壳84的盖90中设有一如传统液晶点阵显示器这样的显示器86及多个输入端88。 Cover 90 is provided in the housing 84 of the conventional liquid crystal matrix displays such as a display 86 and a plurality of input terminals 88. 所述壳体还限定了一用于容纳给药组件14的细长形接收器92。 The housing further defines an elongate receivers 14 for receiving assembly 92 administration. 在这一实施例中,给药组件14包括一通过输入管96连接至一实际往复式泵压头98的注射器94及一被连接至泵压头98中泵压头出口的输出管100。 In this embodiment, the administration through the input assembly 14 includes a tube 96 is connected to an actual reciprocating pump head 94 and a syringe 98 is connected to the pump head outlet 98 of the pump head outlet tube 100.

注射器94可采用本领域熟知的传统结构。 Syringe 94 can be of conventional construction known in the art. 注射器94还包括一液缸102,其具有一用于容纳柱塞106的开式远端104。 Injector 94 further includes a cylinder 102 having an open distal end 104 for receiving a plunger 106. 液缸102的近端限定了用于液缸102中所含的液体的出口108。 The proximal end of the hydraulic cylinder 102 defines an outlet 102 for the liquid contained in the cylinder 108. 如本领域技术人员易于理解的那样,通过抽出柱塞106可将液体经出口108吸入所述液缸,或通过插入活塞可排出所述液体。 As those skilled in the art will readily be appreciated that, through the liquid outlet 106 may be drawn into the cylinder 108 via withdrawal of the plunger, or the liquid may be discharged by insertion of the piston.

图3更详细地示出了注射器下游的给药组件14以及泵机构。 Figure 3 shows in more detail a dosing syringe assembly 14 and downstream of the pump mechanism. 轴向往复式泵压头98包括同轴设置的泵压头入口110和泵压头出口112,输入管96被连接至泵压头入口110,输出管100被连接至泵压头出口112。 Axially reciprocating pump head 98 includes a coaxial pump head inlet 110 and the pump head outlet 112, inlet tube 96 is connected to the pump head inlet 110, outlet tube 100 is connected to the pump head outlet 112. 在图3的分解图中所示的轴向往复式泵压头98包括一限定了泵腔和一活塞116(参见图3)的液缸114,所述活塞在液缸114内的最小泵腔容积量的排放位置和最大泵容积量的再装填位置之间往复滑动。 Axially reciprocating pump head shown in exploded view in FIG. 3 98 includes a cylinder defining a pump chamber and a piston 116 (see FIG. 3) 114, the minimum of the piston pump chamber 114 within the cylinder reciprocal sliding between the volumetric capacity of the discharge position and the refill position of the maximum volumetric capacity of the pump. 活塞116由连杆118驱动,连杆118还限定了泵压头的出口112。 The piston 116 is driven by a connecting rod 118, the link 118 also defines an outlet 112 of the pump head. 所述连杆还包括一推压盘120,如下文更详细说明的那样,用于促进连杆的动作。 The link further comprises a pushing plate 120, as described in more detail below, to facilitate the operation of the link. 如图4所示,推压盘120为与连杆118分离的独立元件。 As shown, the pressing plate 4120 is separated from the link member 118 separate.

所述给药组件通过一固定块126与泵的驱动装置可控制地相连。 The administration may be coupled to the control assembly by a driving means fixed block 126 of the pump. 固定块126限定了一支架128,其用于容纳轴向往复式泵压头98的液缸114。 Fixing block 126 defines a bracket 128 for receiving the axial reciprocating pump head 98 in the cylinder 114. 在限定于固定块126中的槽130内设有一推动捕捉板适配器(pushcapture plate adapter)124。 Defined to fixed block 126 has a groove 130 on site to promote the capture plate adapter (pushcapture plate adapter) 124. 一凸轮随动件132卡设在固定块126的凹口134内部,且可沿箭头136所示方向、由一偏心置于电动机142的轴140的凸轮138往复线性驱动。 A cam follower 132 provided on the card inside the recess 126 of the fixed block 134, and may be in the direction indicated by arrow 136, by an eccentric cam 138 disposed reciprocating linear shaft 140 drives the motor 142. 从图3中可明显得知,当轴140转动时,通过凸轮随动件与凸轮138边缘啮合,凸轮随动件132沿轴向运动的泵压头98轴线作线性往复运动。 As apparent from FIG. 3 that, when the rotary shaft 140, the cam follower by engagement with the cam edge 138, the cam follower member 132 of the pump head 98 is axially movably linearly reciprocation axis. 可利用一未示出的弹簧偏压凸轮随动件与一凸轮接触。 It may utilize a spring-biased cam follower (not shown) in contact with a cam. 凸轮随动件132的远端限定一个槽144,其容纳了给药组件的连杆118并反作用于推压盘120以轴向驱动泵压头98。 The distal end of the cam follower member 132 defining a slot 144 which accommodates dosing assembly 118 and acts against the link plate 120 is pushed axially to drive the pump head 98.

输出管100最好是一标准静脉注射(Ⅳ)管,该管通常采用聚氯乙烯(PVC)。 Outlet tube 100 is preferably a standard intravenous (Ⅳ) tube, which is usually polyvinyl chloride (PVC). 输出管100可包括一硅酮部分122,其通过捕捉板/适配器124连接至输出管100的主体。 Outlet tube 100 may comprise a silicone portion 122, which is connected to the body through the outlet tube 100 of the capture plate / adapter 124. PVC Ⅳ管(或硅酮部分122)安装在一起到上述图1所示的出口压力传感器58作用的压力检测电阻144之间。 Between the pressure detecting resistor 144 PVC Ⅳ tube (or the silicone section 122) mounted together to said outlet pressure sensor 58 of FIG. 1 shown in action. 压力检测电阻探测与由下游阻塞造成的压力增量相关的管膨胀,并在超过选定压力时,对控制器发出信号。 Detecting resistor detecting a pressure tube expansion associated with the downstream pressure increase caused by blocking, and when exceeds a selected pressure, the controller signaled.

图3为一典型的轴向运动的往复式泵压头98。 3 is a typical reciprocating pump of axial movement of the ram 98. 泵压头98包括一内部设有活塞116的液缸114。 The pump head 98 includes an internal cylinder provided with a piston 116 114. 特别是,球体146容纳在液缸114中且抵靠在液缸114中直径减小的部分148。 In particular, a sphere 146 housed in the cylinder 114 and the cylinder 114 against the reduced diameter portion 148. 随后,将弹簧150设置在液缸内,且抵靠在液缸内、邻接直径减小部分148的凸缘(未示出)。 Subsequently, the spring 150 disposed in the liquid cylinder and the liquid cylinder against the abutment portion 148 of reduced diameter of the flange (not shown). 接着,杆152沿轴向被插入液缸内且衔接弹簧150的远端。 Subsequently, the rod 152 axially inserted into the distal end of the liquid cylinder and spring 150 adapters. 与连杆118一样,活塞116设置在弹簧150上。 As with the rod 118, piston 116 is provided on the spring 150. 连杆118内的小孔154限定了将液体输送至泵压头出口112的导管,盖156与液体114上的凸缘158接合,以使轴向往复运动的泵压头98上的各部件保持在它们的装配位置。 Apertures 154 in the link 118 defines the liquid delivered to the outlet conduit 112 of the pump head, the cap 156 is engaged with the liquid 114 on the flange 158 such that axial reciprocation of the pump head 98 of each holding member in their assembled position. 推压盘120在端接泵压头出口118的孔159中容纳了连杆118的远端。 The pressing plate 120 of the outlet aperture 118 accommodates the distal end 159 of the link 118 terminating pump head. 借助推压盘120轴向将连杆118压入使活塞116运动至排放位置,泵压头经液缸泵送液体。 Axial pushing plate 120 by means of connecting rod 118 is pressed into the piston 116 is moved to the discharge position, the pump head by pumping the liquid cylinder. 通过减小连杆118上的轴向力,弹簧150偏压活塞116至再装填位置。 By reducing the axial force on the link 118, spring 150 biases the piston 116 to a refill position. 当迫使活塞从排放位置朝装填位置运动时,球体146在直径缩小部分148处封闭了泵出口110。 When the piston is forced from the discharge position to the loading position, the ball 146 at the reduced diameter portion 148 closes the outlet 110 of the pump. 因此,在液缸内的液体由泵出口排出。 Thus, in the liquid discharged from the liquid outlet of the pump cylinder. 当弹簧偏压活塞至装填位置时,球体146上的封闭压力减弱且流体流入泵入口110。 When the piston is spring biased to the loading position, the pressure on the ball 146 is closed and fluid flows into the pump inlet weakening 110. 通过一单向止回阀(未示出)可防止液体流入连杆118的泵出口112。 Through a one way check valve (not shown) prevents liquid flow into the pump outlet 118 of the link 112.

泵压头排出行程可为具有一系列步进部分的全排放行程,以提供较小量的快速给药(bolus dosage)或可采用具有快速返回功能的连续全排放行程以提供大致连续的液体流。 The pump head discharge stroke can be a series having a full discharge stroke step portion to provide a small amount of a rapid administration (bolus dosage) or may be used with a fast return of continuous full discharge stroke to provide a substantially continuous stream of the liquid . 如本领域技术人员所理解的那样,可将凸轮形状设计为能允许泵压头机构中的弹簧大体瞬时将泵柱塞从排放位置移至再装填位置,从而开始泵送行程的另一排放部分。 As those skilled in the art will appreciate, the cam may be shaped to allow the pump head spring means substantially instantaneously move the pump plunger from the discharge position refill position, to begin another pumping stroke of the discharge portion .

虽然未示出,可采用一标准Ⅳ袋代替注射器94。 Although not shown, may be employed in place of a standard syringe 94 Ⅳ bags. 显然,这要求对刚性外壳82进行改进。 Obviously, this requires improvement of the rigid housing 82. 另一方面,液体的供给源可远离泵的外壳,并经与一远程贮液器相连的输入管96供给至给药组件14。 On the other hand, the liquid supply may be remote from the pump housing, and is supplied through the input pipe coupled to a remote reservoir assembly 96 to 14 is administered.

本发明的注液泵和给药组件使用了一种标准化泵压头,通过大量用作鼻腔定量,这种泵压头泵压头已证明是精确且非常可靠的。 And administering the injection pump assembly of the present invention uses a standardized pump head, as the nasal cavity through a large quantitative, the pump head pump head has proven to be very reliable and accurate. 结果,在不有损于精确性或可靠性的情况下,使给药组件的成本降至最低。 As a result, without the detriment of the accuracy or reliability of the assembly to minimize the cost of administration. 泵压头的简单线性动作可通过多种不同形式的往复线性驱动装置,包括非常简单、价廉且高可靠性的机构控制。 Simple linear operation of the pump head by a variety of different forms of reciprocating linear drive means, including very simple, inexpensive and highly reliable control mechanism. 给药组件可采用一种泵组件,其包括一能够以不同输送曲线进行注射的预定程序微信息处理器。 A pump assembly can be administered assembly, comprising a conveyor can be injected at different curves of a predetermined program Microprocessor.

Claims (20)

  1. 1. 1. 一种管内给药组件,其包括:一轴向运动的往复式泵压头,其具有一泵压头入口和一泵压头出口;一具有第一和第二端的输入管,所述第一端与所述泵压头入口液态相连,所述第二端适于与一贮液器液态相连;及一具有第一和第二端的输出管,所述第一端与所述泵压头出口液态相连,所述第二端适于与一患者的血管液态相连。 An in-pipe assembly administration, comprising: an axial reciprocating movement of the pump head having a pump head inlet and a pump head outlet; having a first end and a second input transistor, the first end of the pump head is connected to the liquid inlet, said second end adapted to be connected to a liquid reservoir; and having a first end and a second outlet tube, the first end and the pump head outlet liquid connected to said second end adapted to be connected with a liquid vessel of a patient.
  2. 2. 2. 根据权利要求1所述的管内给药组件,其特征在于:所述轴向运动的往复式泵压头包括一可滑动地容纳在一液缸中的活塞,所述活塞可在液缸内的排放位置和再装填位置之间轴向运动,以将液体吸入所述泵压头入口并从所述泵压头出口排出液体。 The inner tube assembly administration according to claim 1, wherein: the axial movement of the reciprocating pump head comprises a slidably received in a cylinder of a piston in a fluid cylinder may be discharge position and axial movement between the refill position to the liquid suction inlet of the pump head and the liquid is discharged from the outlet of the pump head.
  3. 3. 3. 根据权利要求2所述的管内给药组件,其特征在于:所述轴向运动的往复式泵压头还包括一与所述液缸液态相连的控制阀,用以当所述活塞从排放位置移动至再装填位置时,使液流仅从所述泵压头入口进入所述液缸,且当所述活塞从再装填位置移动至排放位置时,使液流仅从所述泵压头出口排出。 The inner tube assembly administration according to claim 2, wherein: the axial movement of the reciprocating pump head further comprises a control valve connected to said liquid cylinder to the discharge position when the piston when moved to the refill position, so that fluid flow only from the pump inlet into the cylinder head, and when the piston is moved from the refill position to the discharge position so that fluid flow only from the pump head outlet discharge.
  4. 4. 4. 根据权利要求2所述的管内给药组件,其特征在于:所述轴向运动的往复式泵压头还包括一装配至所述活塞的连杆,用于在排放位置和再装填位置之间移动所述活塞,所述连杆与一线性往复驱动装置接合。 The administration of the inner tube assembly of claim 2, characterized in that: the axial movement of the reciprocating pump head further comprises a rod fitted to the piston, between the discharge position and for recharging position moving the piston, the connecting rod and a linear reciprocating drive means engagement.
  5. 5. 5. 根据权利要求1所述的管内给药组件,其特征在于:其还包括一与所述输入管中第二端液态相连的贮液器,所述贮液器包括一具有液缸的注射器,所述液缸具有一开式第一端和一限定了液体出口的第二端,及可滑动地容纳在所述开式第一端的活塞,所述输入管的第二端与所述液缸的液体出口相连。 The inner tube assembly administration according to claim 1, characterized in that: further comprising a reservoir tube with said input terminal coupled to a second liquid, the reservoir comprising a cylinder of a syringe, the said hydraulic cylinder having a first open end and a liquid outlet defining a second end and slidably received in the first open end of said piston, said second inlet tube end of the cylinder It is connected to a liquid outlet.
  6. 6. 6. 根据权利要求1所述的管内给药组件,其特征在于:所述往复泵压头的泵压头入口和泵压头出口沿所述泵压头轴向设置。 The inner tube assembly administration according to claim 1, wherein: the reciprocating pump head pump head inlet and a pump head outlet of the pump head in the axial direction is provided.
  7. 7. 7. 一种管内注液泵,其包括:一轴向运动的往复式泵压头,其具有一泵压头入口和一泵压头出口;一壳体,其具有容纳所述泵压头的泵压头接收器;一贮液器;一具有第一和第二端的输入管,所述第一端与所述泵压头入口液态相连,所述第二端与一贮液器液态相连;一具有第一和第二端的输出管,所述第一端与所述泵压头出口液态相连,所述第二端适于与一患者的血管液态相连;及一线性往复驱动装置,其在所述壳体内与泵压头可控制地相连。 An in-pipe injection pump, comprising: an axial reciprocating movement of the pump head having a pump head inlet and a pump head outlet; a housing having a pump housing the pump head pressure the receiver head; a reservoir; having a first end and a second inlet tube, the first end connected to the liquid inlet of the pump head, the second end connected to a liquid reservoir; having first and second outlet tube end, said first end connected to the liquid outlet of the pump head, the second end adapted to be connected with a liquid vessel of a patient; and a linear reciprocating drive apparatus, in which the It can be controllably connected to the inner housing and the pump head.
  8. 8. 8. 根据权利要求7所述的管内注液泵,其特征在于:所述贮液器安装在所述壳体内部。 An inner tube according to claim 7, the injection pump, characterized in that: the reservoir is mounted inside the housing.
  9. 9. 9. 根据权利要求7所述的管内注液泵,其特征在于:所述贮液器包括一具有液缸的注射器,所述液缸具有一开式第一端和一限定了液体出口的第二端,以及可滑动地容纳在所述开式第一端的活塞,所述输入管的第二端与所述液缸的液体出口相连。 According to claim 7, inner tube injection pump, characterized in that: the reservoir comprises a syringe having a cylinder, said cylinder having a first open end and a liquid outlet defining a second end , and slidably received in the first open end of said piston, said second end of the inlet tube and the liquid outlet is connected to the cylinder.
  10. 10. 10. 根据权利要求7所述的管内注液泵,其特征在于:所述贮液器包括一Ⅳ袋。 The injection pump as claimed in claim 7 of the inner tube, characterized in that: the reservoir comprises a Ⅳ bag.
  11. 11. 11. 根据权利要求7所述的管内注液泵,其特征在于:所述轴向运动的往复式泵压头包括一可滑动容纳在一液缸中的活塞,所述活塞可在液缸内的排放位置和再装填位置之间轴向运动,以将液体吸入所述泵入口并从所述泵排出液体;及一与所述液缸液态相连的控制阀,用以当所述活塞从排放位置移动至再装填位置时,使液流仅从所述泵压头入口进入液缸,且当所述活塞从再装填位置移动至排放位置时,使液流仅从所述泵压头出口排出,及一装配至所述活塞的连杆,用于在所述排放位置和装填位置之间移动所述活塞,所述连杆与所述线性往复驱动装置接合。 According to claim 7, inner tube injection pump, characterized in that: the axial movement of the reciprocating pump head comprises a discharge can be slidably received in a cylinder of a piston in a fluid cylinder axial movement between the position and the refill position, the suction pump to the liquid inlet and the liquid is discharged from said pump; and a control valve connected to said liquid cylinder, when the piston is moved to the discharge position when the position to refill the liquid flow only from the pump inlet into the cylinder head, and when the piston is moved from the discharge position to the refill position, so that fluid flow only from the pump outlet for discharging head, and a connecting rod fitted to the piston for moving the piston, the linear reciprocating drive link and said engagement means between said loading position and a discharge position.
  12. 12. 12. 根据权利要求7所述的管内注液泵,其特征在于:所述线性往复驱动装置包括一具有一旋转驱动轴的电动机及线性转换器的旋转机构,其可控制地与所述驱动轴和轴向运动的往复式泵压头相连,以便控制所述泵压头。 According to claim 7, inner tube injection pump, wherein: said driving means comprises a linear reciprocating mechanism having a motor and a rotary linear converter of a rotating shaft, which can be controlled with the drive shaft and the shaft connected to the movement of the reciprocating pump head to control the pump head.
  13. 13. 13. 根据权利要求12所述的管内注液泵,其特征在于:所述线性转换器的旋转机构包括一具有边缘的凸轮,所述凸轮偏心固定于所述驱动轴上,及一凸轮随动件,其可控制地与所述凸轮边缘接合并被偏压接触所述凸轮边缘,因此,当所述凸轮转动时,所述凸轮随动件可线性往复运动,所述凸轮随动件与轴向运动的往复式泵压头相连接以便驱动所述泵压头。 The injection pump as claimed in claim 12, wherein the inner tube, characterized in that: said linear converter mechanism comprises a rotary cam having an edge, said eccentric cam fixed to the drive shaft, and a cam follower, which can be controllably engaged with said cam edge and said cam bias contact edge, therefore, when the cam is rotated, the cam follower is linearly reciprocated, the cam follower member movable axially reciprocating pump head connected to drive the pump head.
  14. 14. 14. 根据权利要求7所述的管内注液泵,其还包括:可控制地与所述往复线性驱动装置相连的控制器,用以控制所述泵压头的预定程序操作。 According to claim 7, inner tube injection pump, further comprising: a controller controllably connected to the linear reciprocal drive means, for a predetermined program to control the operation of the pump head.
  15. 15. 15. 根据权利要求14所述的管内注液泵,其还包括:一可控制地与所述输出管相连并与所述控制器耦合连接的压力传感器,用以探测下游阻塞。 According to claim 14, inner tube injection pump, further comprising: a controllably coupled with said output pipe and connected to the pressure sensor coupled to the controller, for detecting a downstream obstruction.
  16. 16. 16. 根据权利要求14所述的管内注液泵,其还包括:一可控制地与所述线性驱动装置相连并与所述控制器耦合连接的编码器,用以对所述控制器发出表示泵输出量的信号。 According to claim 14, inner tube injection pump, further comprising: a controllably connected to said linear drive and is connected to an encoder coupled to said controller, said controller to issue an output indicating that the pump the amount of signal.
  17. 17. 17. 一种对患者进行管内注射药液的方法,其包括;设置一轴向运动的往复式泵压头,该泵压头具有一泵压头入口和一泵压头出口;设置一输入管和一输出管,所述输入管和输出管均具有第一和第二端;使所述输入管的第一端与所述泵压头入口液态相连,且所述输入管的第二端与一贮液器液态相连;使所述输出管的第一端与所述泵压头出口液态相连,且其第二端与一患者的血管液态相连;使一往复线性驱动装置与所述泵压头可控制地相连;以及驱动所述往复线性驱动装置。 A method of injecting liquid medicine to a patient tube, comprising; provided a reciprocating pump head axial movement, the pump head having a pump head inlet and a pump head outlet; provided with a supply line and a output tube, said inlet and outlet tubes each having a first and a second end; the first input terminal is connected to the liquid inlet of the pump head, and said second inlet tube end and a reservoir tube liquid accumulator connected; outlet tube to the first end and the pump head is connected to the liquid outlet, and a second end with a patient connected to a liquid vessel; make a reciprocating linear drive means and said pump head may be controllably connected; and driving the reciprocating linear drive.
  18. 18. 18. 根据权利要求17所述的方法,其还包括:设置一可控制地与所述往复线性驱动装置相连的编码器,以便根据上述每次往复操作产生一信号;设置一与所述编码器相连的控制器,用以接收对于所述往复线性驱动装置的信号;及设定所述控制器的程序,用以控制所述线性驱动装置的动作速率并根据从所述编码器接受的信号来计算泵压头的输出量。 The method of claim 17, further comprising: providing an encoder coupled to a controllably with the reciprocating linear drive means, so as to generate a signal according to the operation by reciprocating; provided with an encoder coupled to the a controller for receiving a signal to the linear reciprocating driving means; and a program set in the controller, for controlling the rate of operation of the linear drive and to calculate pump according to a signal received from said encoder output indenter.
  19. 19. 19. 根据权利要求17所述的方法,其特征在于:所述轴向运动的往复式泵压头包括一鼻腔定量喷雾泵机构,该机构包括一雾化器,所述方法还包括阻塞雾化器。 The method according to claim 17, wherein: the reciprocating axial movement of the pump head comprises a nasal metered pump mechanism which comprises a nebulizer, the method further comprises blocking the atomizer.
  20. 20. 20. 根据权利要求17所述的方法,其还包括:设置一作为贮液器的注射器,所述注射器为一液缸,其具有一开式第一端和一限定了液体出口的第二端,以及容纳在所述开式第一端的柱塞;使所述输入管的第二端与所述注射器液缸的液体出口相连;通过驱动所述往复线性驱动装置,在所述注射器的液体出口产生负压力,以便从所述注射器中抽出液体。 The method according to claim 17, further comprising: providing a reservoir of a syringe, the syringe is a cylinder having a first open end and a liquid outlet defining a second end, and received in the first open end of the plunger; that the second end of the inlet tube connected to a liquid outlet of the syringe cylinder; by driving the reciprocating linear drive device in a liquid outlet of the syringe a negative pressure to draw liquid from the syringe.
CN 99804498 1999-02-01 1999-12-03 Metered dose infusion pump and method CN1295486A (en)

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