CN1267292A - 法呢基蛋白转移酶的新的苯基取代的三环抑制剂 - Google Patents

法呢基蛋白转移酶的新的苯基取代的三环抑制剂 Download PDF

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Publication number
CN1267292A
CN1267292A CN98808215A CN98808215A CN1267292A CN 1267292 A CN1267292 A CN 1267292A CN 98808215 A CN98808215 A CN 98808215A CN 98808215 A CN98808215 A CN 98808215A CN 1267292 A CN1267292 A CN 1267292A
Authority
CN
China
Prior art keywords
compound
alkyl
milliliters
methyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98808215A
Other languages
English (en)
Chinese (zh)
Inventor
A·阿丰索
J·M·凯利
J·温斯坦
R·L·沃林
S·B·罗森布卢姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN1267292A publication Critical patent/CN1267292A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN98808215A 1997-06-17 1998-06-15 法呢基蛋白转移酶的新的苯基取代的三环抑制剂 Pending CN1267292A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87705297A 1997-06-17 1997-06-17
US08/877,052 1997-06-17

Publications (1)

Publication Number Publication Date
CN1267292A true CN1267292A (zh) 2000-09-20

Family

ID=25369151

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98808215A Pending CN1267292A (zh) 1997-06-17 1998-06-15 法呢基蛋白转移酶的新的苯基取代的三环抑制剂

Country Status (10)

Country Link
EP (1) EP0989981A1 (ko)
JP (1) JP2002504150A (ko)
KR (1) KR20010013945A (ko)
CN (1) CN1267292A (ko)
AU (1) AU8253798A (ko)
CA (1) CA2293549C (ko)
HU (1) HUP0003215A2 (ko)
IL (1) IL133446A0 (ko)
NZ (1) NZ501613A (ko)
WO (1) WO1998057950A1 (ko)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
ZA947969B (en) * 1993-10-15 1996-07-12 Schering Corp Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
ATE210652T1 (de) * 1993-10-15 2001-12-15 Schering Corp Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
PL185597B1 (pl) * 1995-12-22 2003-06-30 Schering Corp Tricykliczne amidy, środek farmaceutyczny i ich zastosowania

Also Published As

Publication number Publication date
IL133446A0 (en) 2001-04-30
CA2293549A1 (en) 1998-12-23
NZ501613A (en) 2001-11-30
WO1998057950A1 (en) 1998-12-23
AU8253798A (en) 1999-01-04
KR20010013945A (ko) 2001-02-26
HUP0003215A2 (hu) 2001-06-28
EP0989981A1 (en) 2000-04-05
CA2293549C (en) 2008-08-05
JP2002504150A (ja) 2002-02-05

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WD01 Invention patent application deemed withdrawn after publication