CN1235624C - Medicine for treating cancer and preparing process thereof - Google Patents
Medicine for treating cancer and preparing process thereof Download PDFInfo
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- CN1235624C CN1235624C CN 200410012278 CN200410012278A CN1235624C CN 1235624 C CN1235624 C CN 1235624C CN 200410012278 CN200410012278 CN 200410012278 CN 200410012278 A CN200410012278 A CN 200410012278A CN 1235624 C CN1235624 C CN 1235624C
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Abstract
The present invention provides a medicine for treating cancer and a preparation method thereof. The medicine of the present invention is prepared from angelica, aweto, copper rust, sun plant, calamine, ledebouriella root, harmel, medical stone powder and iron ore powder. The medicine of the present invention can be made into conventional pharmaceutical dosage forms, preferably an injectable dosage form. The medicine of the present invention is a new medicine for treating respiratory system cancer, digestion system cancer and blood system cancer, such as lung cancer, liver cancer, gastric cancer, intestinal cancer, leukemia, etc. The medicine of the present invention can also be used for treating organophosphorus pesticide poisoning, and has a function of deintoxication.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine that is used for the treatment of cancer and preparation method thereof.
Background technology
Tumor is a commonly encountered diseases, and benign tumor quite malignant tumor see that but malignant tumor is that its PD of cancer is swift and violent more, cure rate low, the mortality rate height is one of serious disease that is endangering human body health.Treatment for cancer is key subjects of current medical circle.In known technology, the types of drugs that is used for the treatment of at present cancer both at home and abroad is various, oral liquid such as the treatment cancer, capsule, pill, medicine for external use etc., certain curative effect is all respectively arranged, but the Chinese medicine that is used for the treatment of cancer is less, its main cause is the complicated process of preparation of Chinese medicine, technical merit is had relatively high expectations, and the flavour of a drug that have can not be produced injection, thereby the development that makes Chinese medicine has been subjected to certain restriction, especially along with the continuous development and the scientific and technological progress of China's Chinese medicine cause, pressing for of human health also awaits the novel drugs that cancer is treated in constantly development and exploitation.
Summary of the invention
In order to develop the novel drugs of treatment cancer, the present invention's purpose provides the herbal mixture compositions of the various cancers of a kind of effective treatment.
The technical solution adopted in the present invention is: according to China's Chinese medical theory, in conjunction with the clinical treatment result of the test, selected employing by Radix Angelicae Sinensis, winter dote on, Aerugo, Herba Portulacae Grandiflorae, Calamina, Radix Saposhnikoviae, Herba pegani harmalae, Maifanitum powder, iron ore powder is raw material, be by weight ratio:
Radix Angelicae Sinensis 60-80 weight portion
Winter is doted on the 3-14 weight portion
Aerugo 40-60 weight portion
Herba Portulacae Grandiflorae 60-100 weight portion
Calamina 60-100 weight portion
Radix Saposhnikoviae 60-100 weight portion
Herba pegani harmalae 500-1000 weight portion
Maifanitum powder 4-12 weight portion
Iron ore powder 3-10 weight portion
Preferred weight part proportioning of aforementioned pharmaceutical compositions is:
Radix Angelicae Sinensis 65-75 weight portion
Winter is doted on the 5-10 weight portion
Aerugo 45-55 weight portion
Herba Portulacae Grandiflorae 70-85 weight portion
Calamina 72-88 weight portion
Radix Saposhnikoviae 70-85 weight portion
Herba pegani harmalae 700-850 weight portion
Maifanitum powder 5-10 weight portion
Iron ore powder 4-8 weight portion
The present invention treats the preparation method of cancer drug, and it is any with the said regular dosage form of middle pharmaceutics above-mentioned pharmaceutical composition can be prepared into capsule, pill, tablet, powder, oral liquid etc. according to the Chinese medicine preparation technology of routine.
Above-mentioned pharmaceutical composition preferred for preparation becomes Chinese medicine, and its preparation method is as follows:
A, with Radix Angelicae Sinensis, the winter of said components dote on, this 7 flavor Chinese medicinal herbs of Aerugo, Herba Portulacae Grandiflorae, Calamina, Radix Saposhnikoviae, Herba pegani harmalae after 20-24 hour, filters out medicinal liquid with 60-80 ℃ water logging bubble successively;
B, with Maifanitum powder, iron ore powder with behind soak with ethanol 12-14 days of 75%-95%, filter out medicinal liquid;
C, above-mentioned each medicinal liquid that filters out is mixed, jolting 10 minutes is filtered, and reclaims ethanol, to be deployed into every milliliter through jolting, filtering admixing medical solutions again and be equivalent to crude drug 0.7 gram, place and transfer pH value, with micropore ultrafilter (CA3 film), after the pressure ultrafiltration with the 3kg/ square centimeter to 4.5-5.5, embedding, autoclaving 30 minutes makes water white transparency shape injection, is the Chinese medicine injection of treatment cancer of the present invention.
The present invention is the modern Chinese medicine pharmacological research of combining closely, and carries out prescription according to the monarch principle of Chinese medicine, selected optimum amount proportioning, the medicine of this treatment that is developed into cancer.In the selected prescription, monarch drug is to dote in Radix Angelicae Sinensis, winter, and ministerial drug is Aerugo, Herba Portulacae Grandiflorae, and assistant, messenger drug are Calamina, Radix Saposhnikoviae, Herba pegani harmalae, Maifanitum powder and iron ore powder.The monarch drug Radix Angelicae Sinensis: sweet in the mouth, suffering, hardship, warm in nature, go into liver heart spleen channel, the merit of enriching blood with blood is arranged, can support honor and nourish blood, nourshing blood and promoting blood circulation and in keep, the QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all have deficient disease do not have unsuitable; Winter dotes on: nourishing the lung and kidney, hemostasis and phlegm.Ministerial drug Aerugo: control the malignant boil hemostasis and pain-relieving; Herba Portulacae Grandiflorae: effect with heat-clearing and toxic substances removing; The auxiliary monarch drug of ministerial drug promotes the efficacy of a drug to bring into play lastingly, fills blood, and the replenishing essence marrow, the cold expelling knot, the detumescence tumor has the merit of pain relieving dissipation softening the hard mass to tumor.Adjuvant drug can be assisted a ruler in governing a country monarch, ministerial drug, promotes drug absorption and effect performance, removing toxic substances and promoting subsidence of swelling pain relieving simultaneously.Messenger drug is led all medicine infiltrations, makes medicine absorb the performance effect.Radix Saposhnikoviae: go into bladder, liver spleen channel, have wind-damp dispelling, the analgesic effect; Calamina: property is flat, goes into the stomach warp, has hemostasia and detumescence, holds back humidogene flesh, anticorrosionly removes effects such as mashed; Herba pegani harmalae: salty in the mouth, heat-clearing and toxic substances removing, logical intestinal; Maifanitum powder: the trace element such as ferrophosphorus sodium potassium that contain the human body needs; Iron ore powder: the trace element such as ferrum, calcium, phosphorus, potassium, sodium, zinc that is rich in needed by human body.Prescription of the present invention prefecture, minister, assistant, messenger drug compatibility complement each other, and have YANG invigorating and press down the moon, eliminating pathogenic factor for supporting vital QI, nourshing blood and promoting blood circulation, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cold expelling knot, detumescence tumor, trace element supplement strengthens body immunity, suppresses the cell cancerization, recovers the effect of normal function.Its major function is that anticancer generates, and kills the cancerous cell in the histiocyte and purifies the blood, and the newborn antibody that produces after the medication is the human body enhancing immunity.
The present invention treats the medicine of cancer owing to adopted technique scheme, moving tumor effect experiment result through the Tianjin Institute of Medicine Science animal shows, this medicine meets effective standard of national regulation, truly have certain tumor-inhibiting action making under the suitable situation of dosage, at still a kind of preparation objectively with active anticancer.Warp is to 100 routine patients clinical observation of curative effect again, its advantage is that curative effect is reliable, especially optimizing injection of the present invention is directly annotated in blood, effect obviously, can be used for the treatment of effectively that to breathe be that cancer, cancers in digestive system disease, blood are cancer etc., such as pulmonary carcinoma, hepatocarcinoma, gastric cancer, intestinal cancer, leukemia etc., be a kind of novel drugs for the treatment of cancer.Medicine of the present invention also can be used for the treatment of organophosphate poisoning, has Detoxication.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail.
Embodiment 1
Medicine of the present invention is to make (by weight) by following concrete prescription:
68 parts of Radix Angelicae Sinensis, winter are doted on 8 parts, 53 parts of Aerugo, 82 parts of Herba Portulacae Grandifloraes, 76 parts of Calaminas, 72 parts of Radix Saposhnikoviaes, 750 parts of Herba pegani harmalaes, 6 parts in Maifanitum powder, 5 parts of iron ore powders.
The present invention is prepared into the method for Chinese medicine:
A, with Radix Angelicae Sinensis, the winter of said components dote on, this 6 flavor Chinese medicinal herbs weighing of Aerugo, Herba Portulacae Grandiflorae, Calamina, Radix Saposhnikoviae, Herba pegani harmalae, after 24 hours, filter out medicinal liquid with 60-80 ℃ water logging bubble successively;
B, Maifanitum powder, iron ore powder after 14 days, are filtered out medicinal liquid with 95% soak with ethanol;
C, above-mentioned each medicinal liquid that filters out is mixed, jolting 10 minutes, filter, reclaim ethanol, will be deployed into every milliliter through jolting, filtering admixing medical solutions again and be equivalent to crude drug 0.7 gram, place and transfer pH value to 4.5-5.5, with micropore ultrafilter (CA3 film), after the pressure ultrafiltration with the 3kg/ square centimeter, embedding, autoclaving 30 minutes makes water white transparency shape injection.
Embodiment 2
Medicine of the present invention is to make (by weight) by following concrete prescription:
73 parts of Radix Angelicae Sinensis, winter are doted on 6 parts, 50 parts of Aerugo, 78 parts of Herba Portulacae Grandifloraes, 75 parts of Calaminas, 80 parts of Radix Saposhnikoviaes, 800 parts of Herba pegani harmalaes, 7 parts in Maifanitum powder, 6 parts of iron ore powders.
The present invention is prepared into the method for Chinese medicine:
A, with Radix Angelicae Sinensis, the winter of said components dote on, this 6 flavor Chinese medicinal herbs weighing of Aerugo, Herba Portulacae Grandiflorae, Calamina, Radix Saposhnikoviae, Herba pegani harmalae, after 24 hours, filter out medicinal liquid with 60-80 ℃ water logging bubble successively;
B, with Maifanitum powder, iron ore powder weighing, the soak with ethanol with 95% filtered out medicinal liquid after 13 days;
C, above-mentioned each medicinal liquid that filters out is mixed, jolting 10 minutes is filtered, and reclaims ethanol, admixing medical solutions is deployed into every milliliter is equivalent to crude drug 0.7 gram, place and transfer pH value, with micropore ultrafilter (CA3 film), after the pressure ultrafiltration with the 3kg/ square centimeter to 4.5-5.5, embedding, autoclaving 30 minutes makes water white transparency shape injection, is the Chinese medicine injection of treatment cancer of the present invention.
Claims (6)
1, a kind of medicine for the treatment of cancer is characterized in that it is to be made by the raw material of following weight portion:
Radix Angelicae Sinensis 60-80 weight portion
Winter is doted on the 3-14 weight portion
Aerugo 40-60 weight portion
Herba Portulacae Grandiflorae 60-100 weight portion
Calamina 60-100 weight portion
Radix Saposhnikoviae 60-100 weight portion
Herba pegani harmalae 500-1000 weight portion
Maifanitum powder 4-12 weight portion
Iron ore powder 3-10 weight portion.
2, treatment cancer drug according to claim 1 is characterized in that it is to be made by the raw material of following weight portion:
Radix Angelicae Sinensis 65-75 weight portion
Winter is doted on the 5-10 weight portion
Aerugo 45-55 weight portion
Herba Portulacae Grandiflorae 70-85 weight portion
Calamina 72-88 weight portion
Radix Saposhnikoviae 70-85 weight portion
Herba pegani harmalae 700-850 weight portion
Maifanitum powder 5-10 weight portion
Iron ore powder 4-8 weight portion.
3, the medicine of treatment cancer according to claim 1 and 2, the dosage form that it is characterized in that this medicine are any pharmaceutical dosage forms commonly used.
4, the medicine of treatment cancer according to claim 3, the dosage form that it is characterized in that this medicine is an injection.
5, a kind of preparation method for the treatment of the injection of cancer is characterized in that the raw material composition and the manufacture method of this method is:
Radix Angelicae Sinensis 60-80 weight portion
Winter is doted on the 3-14 weight portion
Aerugo 40-60 weight portion
Herba Portulacae Grandiflorae 60-100 weight portion
Calamina 60-100 weight portion
Radix Saposhnikoviae 60-100 weight portion
Herba pegani harmalae 500-1000 weight portion
Maifanitum powder 4-12 weight portion
Iron ore powder 3-10 weight portion
Radix Angelicae Sinensis with above-mentioned weight portion, winter dotes on, Aerugo, Herba Portulacae Grandiflorae, Calamina, after this 6 flavor Chinese medicinal herbs of Radix Saposhnikoviae and Herba pegani harmalae steeps 20-24 hour with 60-80 ℃ water logging successively, filter out medicinal liquid, with the Maifanitum powder of above-mentioned weight portion and iron ore powder with behind soak with ethanol 12-14 days of 75%-95%, filter out medicinal liquid, each medicinal liquid that filters out more than inciting somebody to action again mixes, jolting 10 minutes, filter, reclaim ethanol, will be through jolting, filtering admixing medical solutions is deployed into every milliliter and is equivalent to crude drug 0.7 gram, place and transfer pH value to 4.5-5.5, use the micropore ultrafilter, after the pressure ultrafiltration with the 3kg/ square centimeter, embedding, autoclaving 30 minutes makes water white transparency shape injection.
6, the preparation method of treatment cancer injection according to claim 5 is characterized in that the raw material composition and the manufacture method of this method is:
Radix Angelicae Sinensis 65-75 weight portion
Winter is doted on the 5-10 weight portion
Aerugo 45-55 weight portion
Herba Portulacae Grandiflorae 70-85 weight portion
Calamina 72-88 weight portion
Radix Saposhnikoviae 70-85 weight portion
Herba pegani harmalae 700-850 weight portion
Maifanitum powder 5-10 weight portion
Iron ore powder 4-8 weight portion
Radix Angelicae Sinensis with above-mentioned weight portion, winter dotes on, Aerugo, Herba Portulacae Grandiflorae, Calamina, after this 6 flavor Chinese medicinal herbs of Radix Saposhnikoviae and Herba pegani harmalae steeps 20-24 hour with 60-80 ℃ water logging successively, filter out medicinal liquid, with the Maifanitum powder of above-mentioned weight portion and iron ore powder with behind soak with ethanol 12-14 days of 75%-95%, filter out medicinal liquid, each medicinal liquid that filters out more than inciting somebody to action again mixes, jolting 10 minutes, filter, reclaim ethanol, will be through jolting, filtering admixing medical solutions is deployed into every milliliter and is equivalent to crude drug 0.7 gram, place and transfer pH value to 4.5-5.5, use the micropore ultrafilter, after the pressure ultrafiltration with the 3kg/ square centimeter, embedding, autoclaving 30 minutes makes water white transparency shape injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410012278 CN1235624C (en) | 2004-05-08 | 2004-05-08 | Medicine for treating cancer and preparing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410012278 CN1235624C (en) | 2004-05-08 | 2004-05-08 | Medicine for treating cancer and preparing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1569108A CN1569108A (en) | 2005-01-26 |
| CN1235624C true CN1235624C (en) | 2006-01-11 |
Family
ID=34477993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410012278 Expired - Fee Related CN1235624C (en) | 2004-05-08 | 2004-05-08 | Medicine for treating cancer and preparing process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1235624C (en) |
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2004
- 2004-05-08 CN CN 200410012278 patent/CN1235624C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1569108A (en) | 2005-01-26 |
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Granted publication date: 20060111 Termination date: 20140508 |