CN121911020A - Cervical vagus nerve stimulation device - Google Patents

Abstract

The application relates to a cervical vagus nerve stimulation device. The cervical vagus nerve stimulation device includes a semi-enclosed base member having an opening and an electrical stimulation unit disposed within the base member. The base member is configured to be able to enlarge the opening so that the opening can pass through the neck of a human body and to narrow the opening to be caught on the neck of the human body. The electrical stimulation unit is used for generating electrical pulses, and comprises at least one pair of electrodes. The at least one pair of electrodes are arranged on the inner side surface of the base body part, the inner side surface of the base body part is a side surface close to the cervical skin, and the electrodes are used for being stuck to the cervical skin by means of elastic restoring force of the base body part when the base body part is clamped on the cervical of a human body so as to output electric pulses to stimulate the cervical vagus nerve. The neck-type cervical vagus nerve stimulation device provided by the application is firm and comfortable to wear, reliable in electrode contact, small in limitation on activities of users and convenient for daily use at home.

Description

Cervical vagus nerve stimulation device

Technical Field

The application relates to the technical field of nerve stimulation devices, in particular to a cervical vagus nerve stimulation device.

Background

The vagus nerve is one of important nerves in the human body, and has a vital regulatory effect on various physiological functions such as heart rate, digestion, inflammatory response and emotion regulation. In recent years, methods for treating conditions such as epilepsy, depression, anxiety, migraine, inflammatory disorders, and heart failure by electrically stimulating the vagus nerve have become an effective clinical treatment strategy. At present, the main vagal nerve stimulation technology in clinic is mainly an invasive scheme, namely, a pulse generator and an electrode are implanted into a patient through surgery, although the implantation mode has definite effect, the implantation mode has traumatism, can bring operation risks, pain and long recovery period to the patient, can leave permanent foreign matters in the body, has potential risks of infection, equipment failure or displacement and the like, and has high cost of the equipment and implantation operation, and brings heavy economic burden to the patient and a social medical security system.

To overcome the above drawbacks of invasive approaches, non-invasive vagal nerve stimulation techniques have been developed and are a hotspot of research. Non-invasive stimulation is mainly performed by means of percutaneous electrical stimulation, in which electrodes are placed at corresponding positions on the skin, and the underlying vagus nerve is stimulated indirectly. Existing non-invasive devices are often large, requiring the patient to be in a fixed sitting or lying position, which greatly limits the freedom of movement of the patient during treatment, resulting in poor treatment compliance, and difficulty in ensuring long-term, regular treatment. In addition, existing non-invasive devices are generally simpler in ergonomic design, fail to adequately account for the comfort of long wear, and tend to result in neck fatigue.

In view of this, a new technical solution is necessary to overcome the drawbacks of the prior art.

Disclosure of Invention

Based on the above, the neck-type cervical vagus nerve stimulation device is firm and comfortable to wear, reliable in electrode contact, small in limitation on activities of users and convenient for daily use at home.

Therefore, the application adopts the following technical scheme that the cervical vagus nerve stimulation device comprises:

a base member having an opening and being semi-surrounding, the base member being configured to be able to enlarge the opening so that the opening can pass through a human neck, and to be able to narrow the opening so as to be caught on the human neck;

An electrical stimulation unit disposed within the base member for generating electrical pulses, the electrical stimulation unit comprising at least one pair of electrodes;

The at least one pair of electrodes are arranged on the inner side surface of the base body, the inner side surface of the base body is a side surface close to the skin of the neck, and the electrodes are used for being abutted against the skin of the neck when the base body is clamped on the neck of a human body so as to output electric pulses to act on the vagus nerve of the neck.

In some of these embodiments, the base member has elasticity to enable expansion of the opening by elastic deformation and contraction of the opening by elastic restoring force.

In some of these embodiments, the base member includes a resilient housing in the form of a semi-enclosed ring.

In some of these embodiments, the resilient housing comprises a metal sheet and/or a plastic sheet.

In some embodiments, the elastic shell is an integral piece, or the elastic shell is a split piece formed by splicing a plurality of segmented pieces.

In some of these embodiments, the base member further comprises an inner shell connected to the elastic outer shell, the inner shell being provided on an inner side of the elastic outer shell, the inner side of the elastic outer shell being a side facing the skin of the neck in use.

In some of these embodiments, the inner shell includes a flexible body or a flexible liner layer is provided on the inner shell.

In some of these embodiments, the flexible body or the flexible liner layer comprises one or more of silicone, filled cotton, and flexible braid.

In some embodiments, the inner shell is a single piece, or the inner shell is a split piece formed by splicing multiple segmented pieces.

In some of these embodiments, the inner shell is provided with two protrusions near the opening.

In some of these embodiments, the electrode is disposed on the boss.

In some of these embodiments, the boss is resilient.

In some of these embodiments, the electrodes are in a pair disposed on the inside surface of the base member near one end of the opening to act on the left anterior cervical vagus nerve or the right anterior cervical vagus nerve.

In some of these embodiments, the electrodes are provided in two pairs, respectively, on the inner side of the base member and near both ends of the opening to act on the left and right anterior vagus nerve of the neck, respectively.

In some of these embodiments, there is a mounting space between the elastic outer shell and the inner shell, and the electrical stimulation unit includes a circuit board mounted in the mounting space, and a pulse generating circuit is disposed on the circuit board.

In some embodiments, the electrical stimulation unit comprises a battery, which is one or more of a disposable battery, a rechargeable battery, and a charging capacitor.

In some embodiments, the circuit board and the battery are separately disposed at two ends of the base member near the opening, and the circuit board and the battery are electrically connected by a wire disposed in the mounting space.

In some embodiments, the elastic outer shell or the inner shell of the base member is provided with a control key for triggering the circuit board to execute a set function, the control key comprises one or more of an on key, an off key and a stimulation intensity adjusting key, and the control key is in the form of one or more of touch, touch and dial.

In some embodiments, the elastic outer shell or the inner shell of the base component is provided with a chargeable interface, the circuit board is electrically connected with the chargeable interface, or the circuit board is provided with a wireless charging coil.

The cervical vagus nerve stimulation device comprises a semi-surrounding base part with an opening, wherein the base part is configured to expand the opening to enable the opening to penetrate through the neck of a human body and reduce the opening to be clamped on the neck of the human body, the semi-surrounding elastic base part is designed to enable the device to be conveniently worn and stably clamped, hands of a user to be effectively liberated, continuous and stable contact between an electrode and skin is ensured, the electrode is firmly and comfortably worn, the electrode contact is reliable, the limitation on activities of a user is small, daily household use is facilitated, and the reliability and consistency of a stimulation effect are ensured.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments or the conventional techniques of the present application, the drawings required for the descriptions of the embodiments or the conventional techniques will be briefly described below, and it is apparent that the drawings in the following descriptions are only some embodiments of the present application, and other drawings may be obtained according to the drawings without inventive effort for those skilled in the art.

Fig. 1 is a perspective view of one embodiment of a cervical vagus nerve stimulation device of the present application.

Fig. 2 is a perspective view of an embodiment of the cervical vagus nerve stimulation device of the present application from another perspective.

Fig. 3 is a perspective exploded view of one embodiment of the cervical vagus nerve stimulation device of the present application.

Reference numerals of the components are 101, an elastic outer shell, 102, wires, 103, an inner shell, 1031, a boss, 104, a battery, 105, an electrode, 106, a circuit board, 1061, control keys, 107 and an opening.

Detailed Description

In order that the above objects, features and advantages of the application will be readily understood, a more particular description of the application will be rendered by reference to the appended drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. The present application may be embodied in many other forms than described herein and similarly modified by those skilled in the art without departing from the spirit of the application, whereby the application is not limited to the specific embodiments disclosed below.

It will be understood that when an element is referred to as being "mounted" or "disposed" on another element, it can be directly on the other element or intervening elements may also be present. When a component is considered to be "connected" to another component, it can be directly connected to the other component or intervening components may also be present. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and the like are used in the description of the present application for the purpose of illustration only and do not represent the only embodiment.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present application, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise.

In the present application, unless expressly stated or limited otherwise, a first feature "up" or "down" on a second feature may be that the first feature is in direct contact with the second feature, or that the first feature and the second feature are in indirect contact through intermedial media. Moreover, a first feature "above," "over" and "on" a second feature may be a first feature directly above or obliquely above the second feature, or simply indicate that the first feature is higher in level than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely under the second feature, or simply indicating that the first feature is less level than the second feature.

Unless defined otherwise, all technical and scientific terms used in the specification of the present application have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description of the application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and/or" as used in the description of the present application includes any and all combinations of one or more of the associated listed items.

According to the cervical vagus nerve stimulation device provided by the application, the electric stimulation unit is skillfully integrated and firmly worn on the neck of a user by configuring the base member with specific structure and material characteristics, so that non-invasive, convenient and effective vagus nerve stimulation is realized. The following describes in detail specific embodiments.

Referring to fig. 1 to 3, the present application provides a cervical vagus nerve stimulation device including a base member and an electrical stimulation unit. The base member has an opening 107 and has a semi-surrounding structure, and is configured such that the opening 107 can be enlarged by elastic deformation so that the opening 107 can pass through the neck of a human body, and the opening 107 is contracted by its own elastic restoring force to be held in the neck of the human body. The electrical stimulation unit is disposed within the base member for generating electrical pulses, the electrical stimulation unit comprising at least one pair of electrodes 105. The at least one pair of electrodes 105 is disposed on an inner side surface of the base member, that is, a side surface close to the cervical skin, and is used for being stuck to the cervical skin by means of elastic restoring force of the base member when the base member is clamped on the cervical of the human body, so as to output electric pulses to act on the cervical vagus nerve.

The cervical vagus nerve stimulation device provided by the application can be clamped on the neck of a human body through the design of the elastic semi-surrounding annular base body part, so that the device is convenient to wear and stably clamped, the hands of a user are effectively liberated, continuous and stable contact between the electrode 105 and the skin is ensured, the device is stable and comfortable to wear, the electrode 105 is reliably contacted, the activity limit on the user is small, the device is convenient for daily use at home, and the reliability and consistency of the stimulation effect are ensured.

The base part is a supporting and fixing body of the whole device, which presents a semi-encircling annular structure with an opening 107 to be able to adapt well to the physiological contours of the human neck. In this embodiment, a key characteristic of the base member is that it has good elasticity, that is, the base member has elasticity so as to be able to expand the opening by elastic deformation and to contract the opening by elastic restoring force. Specifically, when the user uses the device, the base member can be elastically deformed by manually applying an external force, so that the size of the opening 107 can be temporarily enlarged. This design allows the opening 107 to pass smoothly through and around the neck. Once the external force is removed, the base member automatically returns to its original shape, i.e., the opening 107 is narrowed, by virtue of its own inherent elastic restoring force. The continuous elastic restoring force is converted into a soft and continuous clasping force to the neck, so that the neck-clamping type cervical vagus nerve stimulation device can be stably clamped on the neck. When a user normally rotates, lifts the head, and lowers the head in the wearing process, the neck-type cervical vagus nerve stimulation device can synchronously move along with the neck, and the relative position is not easy to change or fall off due to the general movement of the head and the neck. The clamping mode fundamentally realizes the liberation of the hands of the user and ensures the stability of the position of the device in the treatment process.

Referring to fig. 3, in the present embodiment, the base member is mainly composed of an elastic outer shell 101 and an inner shell 103 disposed inside thereof. The elastic housing 101 serves as the main structural load bearing member and elastic element, the shape and material of which are critical to ensure the stability of the catch. In this embodiment, the elastic casing 101 has a semi-encircling shape, i.e. it is a substantially C-shaped or U-shaped arc beam structure, and when force is applied from two sides of the opening 107 to try to enlarge the opening 107, the whole arc beam structure will bend and deform, and the bending design of the long arm makes it possible for a user to generate a sufficiently large opening displacement with a small breaking force, so that the elastic casing is convenient to wear. In terms of materials, the elastic shell 101 may be made of a metal sheet with certain strength and elasticity, such as a memory alloy, for example, nickel-titanium alloy, stainless steel sheet, or the like, or may be made of a high-performance engineering plastic sheet, such as polyamide, polycarbonate, or a composite material thereof, through an injection molding process. The metal sheet can provide excellent elastic restoring force and durability, while the plastic sheet has advantages in terms of weight, cost, and molding flexibility. The elastic casing 101 may be a single integral piece, as shown in fig. 3, and in other embodiments, the elastic casing 101 may be a separate piece formed by splicing multiple segmented pieces, that is, it may be a combination of multiple pieces. When a plurality of parts are combined, the connection manner and the overall structural design between the parts still need to ensure that the combined elastic shell 101 has overall elasticity meeting the use requirement, for example, in some embodiments, the elastic shell 101 is formed by splicing multiple sections, wherein each section is not deformed, and the connection position between the sections is provided with a movable connection structure and an elastic part, so that the elastic shell 101 is in a deformable semi-annular structure as a whole.

In this embodiment, the inner shell 103 is connected to the elastic outer shell 101 and is disposed inside the elastic outer shell 101, and mainly functions to contact with the skin of a user, improve wearing comfort, and assist in fixing internal components. The inner side of the elastic shell 101 faces the side of the neck skin, i.e. in use. The inner shell 103 can be connected and fixed by a conventional mechanical connection manner such as a buckle, a screw and the like, and an installation space is formed between the inner shell and the screw for installing the electric stimulation unit. The inner shell 103 has the ability to elastically deform following the elastic outer shell 101. The inner shell 103 may be an integral piece, or may be a split piece formed by splicing a plurality of segment pieces. The inner housing 103 as shown in fig. 3 is a single piece, and in other embodiments, the inner housing 103 may be a split piece formed by splicing multiple pieces, i.e., it may be a combination of multiple pieces. When a plurality of parts are used for combination, the connection mode and the overall structural design between the parts still need to ensure that the combined inner shell 103 has overall elasticity meeting the use requirement, for example, in some embodiments, the inner shell 103 is formed by splicing multiple sections, wherein each section is not deformed, and the connection position between the sections is provided with a movable connection structure and an elastic component, so that the inner shell 103 is in a deformable semi-annular structure as a whole. In some embodiments, the inner shell 103 may be a unitary flexible body, such as a soft material of silicone, thermoplastic polyurethane, or the like, and in other embodiments, the inner shell 103 itself may be a semi-rigid structure, such as a plastic piece, but with a separate flexible liner layer on the skin-contacting surface. The material of the integral flexible body or the additional flexible lining layer can comprise one or a combination of more of silica gel, soft filling cotton and comfortable flexible braided fabric with good biocompatibility. The inner shell 103 is provided with a flexible body or a flexible liner layer, so that the holding force transmitted by the elastic outer shell 101 can be more gently and uniformly distributed on the skin to avoid discomfort caused by overlarge local pressure, and on the other hand, the soft contact surface can also increase the friction force with the skin to further prevent the device from sliding, and meanwhile, the skin-friendly feeling is improved, so that the device is suitable for being worn for a long time.

Further, the inner housing 103 is provided with two protrusions 1031 near the opening of the base member. The two protrusions 1031 are arranged symmetrically left and right, and they bulge inward, i.e., in a direction toward the skin. The two protrusions 1031 are specifically designed to be positioned to correspond to and conform to the target stimulation areas on the left and right sides of the neck, respectively, when the device is worn. The configuration of the protrusions 1031 such that the contact pressure of the site with the skin is greater than the flat portion of the inner shell helps to ensure that the functional elements thereon, such as the electrodes 105 provided on the protrusions 1031, remain in continuous, intimate contact with the skin, reducing poor contact due to skin wrinkles, perspiration or slight movement, thereby providing a basic guarantee for effective electrical stimulation.

In this embodiment, the protruding portion 1031 is designed to have elasticity itself, so as to improve the adaptability and comfort of wearing. This flexibility can be achieved in a number of ways, for example, by integrally forming the entire boss 1031 from the same or a softer elastomeric material as the main body portion of the inner shell 103, or by designing the boss 1031 with a hollow cavity or by using a low density elastomeric filler that allows it to deform adaptively when subjected to pressure. The resilient protrusions 1031 can adapt to the neck size, shape and soft tissue thickness differences of different users, and conform to individual unique neck contours by compressive deformation of themselves, thereby expanding the applicable population range of the device. In addition, the elastic material can effectively buffer the local pressure of the electrode to the skin, disperse the pressure, remarkably improve the comfort of wearing for a long time and avoid generating indentation or discomfort.

The electro-stimulation unit is a collection of components for generating stimulation pulses, which are housed and protected inside a base component. The electro-stimulation unit mainly comprises a circuit board 106 for generating electrical pulses, a battery 104 for supplying power and electrodes 105 for delivering the electrical pulses to the human body. The circuit board 106 is provided with a pulse generating circuit, which is generally composed of a microcontroller, a waveform generating chip, a power amplifying circuit and other necessary passive components, and can generate an electric pulse signal with adjustable amplitude, frequency, pulse width and other parameters, and the parameters can be set or selected by doctors or users according to different treatment requirements. As shown in fig. 1 and fig. 3, the elastic outer casing 101 or the inner casing 103 of the base member is provided with a control key 1061 for triggering the circuit board 106 to execute a set function, the control key 1061 includes one or more of an on key, an off key, and a stimulus intensity adjusting key, and the control key 1061 is in the form of one or more of a touch type, and a dial type. The control keys are used for controlling basic functions of the device, such as starting up, shutting down, adjusting the intensity of electric stimulation, and the like. The specific form of the control key can be diversified to adapt to the light and thin requirements of the patch type device. For example, a touch key can be used, a user can control by touching a specific area without physical travel, which is beneficial to keeping the surface of the device flat, and a miniaturized physical key such as a touch switch or a dial switch can be used. The control keys are correspondingly provided with key marks on the elastic shell 101, so that a user can flexibly control the control keys according to own feeling and requirements when using the control keys.

The battery 104 is the source of energy for the device and may be of the type that is a rechargeable battery, such as a lithium polymer battery, or a rechargeable capacitor or a removable and replaceable disposable battery. In order to facilitate the repeated use, the base member is preferably in a chargeable form, and correspondingly, the elastic outer shell 101 or the inner shell 103 of the base member is provided with a chargeable interface, the circuit board 106 is electrically connected with the chargeable interface, or the circuit board 106 is provided with a wireless charging coil. The wireless charging coil can realize non-contact charging, so that the tightness and the use convenience of the device are further improved, and the chargeable interface is used for charging through a charging wire, and can be a magnetic adsorption interface, a Micro-USB interface, a Type-C interface or the like.

Referring to fig. 3, the circuit board 106 and the battery 104 are mounted in a mounting space formed between the elastic outer case 101 and the inner case 103. The circuit board 106 and the battery 104 act as the main weights inside the device, and their layout positions have a significant impact on wearing comfort. In a preferred embodiment, the circuit board 106 and the battery 104 are separately disposed at both ends of the base member near the opening 107 to disperse gravity, and the circuit board 106 and the battery 104 are electrically connected by the lead 102 disposed in the installation space. The circuit board 106 and the battery 104 are arranged at the two ends of the base part close to the opening 107, and the distribution mode is beneficial to distributing the weight of the device on the two sides of the neck more uniformly, so that unbalanced feeling and fatigue feeling caused by the fact that the weight is too concentrated on one side or the rear of the neck are avoided, and the comfort of wearing for a long time is remarkably improved. For electrical connection, the circuit board 106 and the battery 104 are connected by the lead 102 provided in the internal space of the base member.

The electrode 105 is the part of the electro-stimulation unit that is in direct contact with the human body, and in some embodiments is made of a biocompatible conductive material such as medical stainless steel, silver/silver chloride, conductive silicone, etc. The number and placement of the electrodes 105 is directly related to the targeting and effect of the stimulation, in embodiments of the application the electrodes 105 are provided on the inside surface of the base member, which is exposed to the inside surface of the inner housing 103, to ensure that the device is able to penetrate through openings in the inner housing 103 or be in direct contact with the skin when worn. In one embodiment, the electrodes 105 are a pair disposed on the inner side of the base member and near one end of the opening 107 to correspond to the vagal location on the left anterior side of the neck or the right anterior side of the neck, and the pair of electrodes 105 are centrally disposed on the inner side of the base member near one end of the opening 107, such as the vagal body surface projection location corresponding to the left anterior side or the right anterior side of the neck, for unilateral vagal stimulation. This single-sided stimulation scheme is adequate for certain specific conditions and helps simplify the device structure and control logic. In another embodiment, the electrodes 105 are arranged in two pairs on the inner side of the base member and near the two ends of the opening 107 to correspond to the left and right anterior cervical vagal locations, respectively, and the two pairs of electrodes 105 are arranged on the inner side of the base member near the two ends of the opening 107 to correspond to the left and right anterior cervical vagal locations, respectively. This bilateral electrode design allows the device to stimulate the bilateral vagus nerve simultaneously or alternately, which may result in a more balanced or effective therapeutic effect, particularly for diseases requiring bilateral intervention. The electrode 105 can always maintain a stable and proper contact pressure with the neck skin by virtue of the elastic restoring force of the base member, whether a one-sided or a two-sided design is adopted. The stable contact ensures that the electric pulse can be efficiently conducted to subcutaneous tissue with lower impedance and acts on the target vagus nerve, so that stimulation interruption, energy loss or skin burning sensation caused by poor contact is avoided, and the reliability and consistency of the treatment effect are ensured.

Referring to fig. 3 again, a specific assembly process and a using process of the neck-type cervical vagus nerve stimulation device provided by the present application are as follows. First, the electrode 105 is mounted to a predetermined position of the inner case 103 and the electrical connection terminal thereof is secured reliably. Next, the circuit board 106 and the battery 104 are placed and fixed, respectively, in the mounting positions reserved for the inner case 103. The wires 102 are then used to connect the battery 104 to the power input of the circuit board 106 in the correct polarity, while the other set of wires 102 is used to connect the electrodes 105 to the pulse output of the circuit board 106. All wires should be firmly connected and protected by insulation as necessary. Thereafter, the inner case 103, to which the internal components have been mounted, is aligned and assembled with the elastic outer case 101. The assembly mode can be snap fit, screw fastening or ultrasonic welding, etc., so as to ensure that the two are combined to form a complete and stable base component whole with well-protected internal elements. The final assembled device has an initial size of the opening 107 smaller than the diameter of the neck of the user, but can be easily broken off and put on the neck by the elasticity of the elastic housing 101. After wearing, the device will be comfortably and firmly clamped in the neck, with the electrodes 105 held in good contact with the skin under elastic force and facing forward on both sides of the neck, at the cervical vagus nerve. The user can start the treatment by operating the control 1061 and selecting the appropriate stimulation intensity. After the treatment is finished, the device is closed and can be taken off from the neck by the breaking-off device.

In summary, as can be seen from the above description of the specific embodiments, the present application provides a neck-type cervical vagus nerve stimulation device with stable wearing, convenient use, high comfort and reliable stimulation effect by innovatively combining non-invasive electrical stimulation technology with ergonomics through the innovative semi-surrounding annular elastic base member design. The device effectively solves the problems of inconvenient use, limited activity and the like of the non-invasive scheme in the prior art, effectively liberates the hands of a user, ensures continuous and stable contact between the electrodes and the skin, is stable and comfortable to wear, has small limitation on the activities of the user, is convenient for daily household use, ensures the reliability and consistency of the stimulation effect, and provides powerful hardware support for popularization and household application of the non-invasive vagus nerve stimulation therapy.

The above examples illustrate only a few embodiments of the application, which are described in detail and are not to be construed as limiting the scope of the claims. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the application, which are all within the scope of the application. Accordingly, the scope of the application should be determined from the following claims.

Claims (19)

1. A cervical vagus nerve stimulation device comprising:

a base member having an opening and being semi-surrounding, the base member being configured to be able to enlarge the opening so that the opening can pass through a human neck, and to be able to narrow the opening so as to be caught on the human neck;

An electrical stimulation unit disposed within the base member for generating electrical pulses, the electrical stimulation unit comprising at least one pair of electrodes;

The at least one pair of electrodes are arranged on the inner side surface of the base body, the inner side surface of the base body is a side surface close to the skin of the neck, and the electrodes are used for being abutted against the skin of the neck when the base body is clamped on the neck of a human body so as to output electric pulses to act on the vagus nerve of the neck.

2. The cervical vagus nerve stimulation device of claim 1, wherein the base member has elasticity to enable expansion of the opening by elastic deformation and contraction of the opening by elastic restoring force.

3. The cervical vagus nerve stimulation device of claim 1, wherein the base member comprises a semi-encircling annular elastic shell.

4. A cervical vagus nerve stimulation device according to claim 3, wherein the elastic housing comprises a metal sheet and/or a plastic sheet.

5. The cervical vagus nerve stimulation device of claim 4 wherein the elastic housing is a unitary piece or the elastic housing is a split piece of multiple pieces joined together.

6. A cervical vagus nerve stimulation device according to claim 3, wherein the base member further comprises an inner shell connected to the elastic outer shell, the inner shell being provided on the inside of the elastic outer shell, the inside of the elastic outer shell being the side facing the skin of the neck in use.

7. The cervical vagus nerve stimulation device of claim 6, wherein the inner housing comprises a flexible body or a flexible liner layer is disposed on the inner housing.

8. The cervical vagus nerve stimulation device of claim 7, wherein the flexible body or the flexible liner layer comprises one or more of silicone, padded cotton, and flexible braid.

9. The cervical vagus nerve stimulation device of claim 6, wherein the inner housing is a unitary piece or the inner housing is a split piece formed from a plurality of split pieces.

10. The cervical vagus nerve stimulation device of claim 6, wherein the inner housing is provided with two protrusions proximate the opening.

11. The cervical vagus nerve stimulation device of claim 10, wherein the electrode is disposed on the boss.

12. The cervical vagus nerve stimulation device of claim 10, wherein the boss is resilient.

13. The cervical vagus nerve stimulation device of claim 1, wherein the pair of electrodes are disposed on an inner side of the base member and near one end of the opening to act on the left anterior cervical vagus nerve or the right anterior cervical vagus nerve.

14. The cervical vagus nerve stimulation device of claim 1, wherein the electrodes are provided in two pairs, respectively, on the inner side of the base member and near both ends of the opening to act on the left and right anterior vagus nerves of the neck, respectively.

15. The cervical vagus nerve stimulation device of claim 6, wherein there is an installation space between the elastic outer housing and the inner housing, and the electrical stimulation unit includes a circuit board installed in the installation space, and a pulse generating circuit is disposed on the circuit board.

16. The cervical vagus nerve stimulation device of claim 15, wherein the electrical stimulation unit comprises a battery that is one or more of a disposable battery, a rechargeable battery, and a charging capacitor.

17. The cervical vagus nerve stimulation device of claim 16, wherein the circuit board and the battery are separately disposed at both ends of the base member adjacent to the opening, the circuit board and the battery being electrically connected by a lead disposed in the installation space.

18. The cervical vagus nerve stimulation device of claim 15, wherein the elastic outer shell or the inner shell of the base member is provided with a control key for triggering the circuit board to perform a set function, the control key comprises one or more of an on key, an off key and a stimulation intensity adjusting key, and the control key is in the form of one or more of touch, touch and dial.

19. The cervical vagus nerve stimulation device of claim 15, wherein the flexible outer or inner housing of the base member is provided with a rechargeable interface, the circuit board is electrically connected to the rechargeable interface, or a wireless charging coil is provided on the circuit board.