CN120571048A - A dressing for caring for non-chronic wounds on body surface, preparation method and application thereof - Google Patents

A dressing for caring for non-chronic wounds on body surface, preparation method and application thereof

Info

Publication number
CN120571048A
CN120571048A CN202510714106.6A CN202510714106A CN120571048A CN 120571048 A CN120571048 A CN 120571048A CN 202510714106 A CN202510714106 A CN 202510714106A CN 120571048 A CN120571048 A CN 120571048A
Authority
CN
China
Prior art keywords
dressing
medical
calcium carbonate
wound
liquid paraffin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202510714106.6A
Other languages
Chinese (zh)
Inventor
江经纬
王荣刚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jinzhida Medical Equipment Shanghai Co ltd
Original Assignee
Jinzhida Medical Equipment Shanghai Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jinzhida Medical Equipment Shanghai Co ltd filed Critical Jinzhida Medical Equipment Shanghai Co ltd
Priority to CN202510714106.6A priority Critical patent/CN120571048A/en
Publication of CN120571048A publication Critical patent/CN120571048A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention discloses a dressing for nursing a non-chronic wound on a body surface, a preparation method and application thereof, and particularly relates to the technical field of medical dressing, which consists of silicon dioxide, calcium carbonate, medical white vaseline, medical liquid paraffin and medical absorbent gauze or spunlaced non-woven fabric. Wherein, the silicon dioxide has specific surface area and porosity, the calcium carbonate has proper particle size, and the medical white vaseline and liquid paraffin keep specific mass ratio. Through the synergistic effect of the components, the dressing has the advantages of high-efficiency absorption of exudates, good antibacterial performance, optimization of wound healing environment, enhancement of mechanical stability and the like. The preparation method comprises the steps of mixing, heating and stirring, coating and shaping, and the like. The dressing is suitable for nursing non-chronic wounds on body surfaces such as bruises, cuts and burns, and the dressing is replaced once daily without cleaning the surfaces of the wounds when in use, so that the compliance of patients can be improved, and the healing of the wounds can be promoted.

Description

Body surface non-chronic wound care dressing, preparation method and application
Technical Field
The invention relates to the technical field of medical dressing, in particular to a dressing for nursing a non-chronic wound on a body surface, a preparation method and application thereof.
Background
In the field of medical dressings, body surface wound care has been the focus of research. With the development of medical technology and the improvement of the requirements of people on the quality of wound healing, the traditional body surface wound care dressing gradually exposes a plurality of defects.
At present, some common dressing on the market has the problem of poor adsorption capacity when dealing with non-chronic wounds on the body surface, and can not effectively absorb wound exudates in time, so that the exudates are accumulated for a long time, wound infection is easily initiated, and the healing process is delayed. Meanwhile, most dressings have limited antibacterial effect, and are difficult to resist attack of various common pathogenic bacteria, so that the risk of wound infection is further increased.
In addition, the moisture retention and air permeability properties of these dressings are difficult to balance, either too dry resulting in pain in the wound with chapping, slow healing, or poor air permeability resulting in the wound being in a moist and stuffy environment, with bacterial growth. In actual use, part of the dressing can be tightly adhered to the wound, so that secondary damage is very easy to cause when the dressing is changed, additional pain is brought to a patient, and the treatment compliance of the patient is reduced.
Therefore, a novel body surface non-chronic wound care dressing which can effectively adsorb exudates, has good antibacterial property, balances the moisture and air permeability, reduces the pain of dressing change and can accelerate wound healing is provided.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides a body surface non-chronic wound care dressing, a preparation method and application thereof, so as to solve the problems in the background art.
The invention provides a technical scheme for realizing the aim, which comprises the following components of silicon dioxide, calcium carbonate, medical white vaseline, medical liquid paraffin, chitosan and medical absorbent gauze or spunlaced non-woven fabric;
the specific surface area of the silicon dioxide is 200-500m 2/g, the porosity is 60-90%, the particle size of the calcium carbonate is 1-10 mu m, the mass ratio of the medical white vaseline to the medical liquid paraffin is 1:1-1:3, and the addition amount of the chitosan is 2-5% of the total mass of the dressing.
Through the synergistic effect of the adsorption and blocking effect of the silicon dioxide, the pH adjustment and coagulation function of the calcium carbonate, the moisture retention and lubrication of medical white vaseline and the liquid absorption and ventilation performance of medical absorbent gauze/spunlaced non-woven fabric, the effects of wound exudate adsorption, infection risk reduction, healing environment optimization and improvement of dressing mechanical stability are realized, and the silicon dioxide with proper particle size and surface property can positively influence the growth and proliferation of cells, promote the growth and migration of cells related to wound healing, such as fibroblasts and the like, so as to accelerate the healing process of wounds.
Specifically, the silicon dioxide has larger specific surface area and pore structure, and has good adsorption performance. On the one hand, the wound dressing can adsorb exudates on the surface of the wound, keep the wound moderately dry and is beneficial to wound healing, on the other hand, the wound dressing can adsorb peculiar smell substances, reduce peculiar smell generated by the wound and improve the hospitalization experience of patients;
The strength and toughness of the dressing can be improved by adding the silicon dioxide into the inorganic dressing, so that the dressing is less prone to damage in the use process, the wound can be better protected, and meanwhile, the operation and fixation are convenient;
and a layer of uniform protective film can be formed, so that external bacteria, dust and other pollutants are effectively prevented from contacting the wound, the risk of wound infection is reduced, and a relatively clean environment is provided for wound healing.
The calcium carbonate can react with acidic substances in wound exudates to play a role in neutralizing acidity, so that the pH value of a local part of a wound is regulated, a proper microenvironment is created for wound healing, in general, the ideal pH value for wound healing is slightly alkaline, and the calcium carbonate is beneficial to regulating the wound environment to an alkaline direction which is beneficial to healing;
calcium carbonate can activate coagulation factors and accelerate blood coagulation, thereby playing a role in stopping bleeding, and in wound treatment, rapid hemostasis is very important for preventing excessive blood loss and subsequent wound healing;
calcium is an important constituent of human bone and teeth and plays a key role in the physiological functions of cells. In the wound healing process, a proper amount of calcium is beneficial to promoting the proliferation and differentiation of cells, particularly has a certain promoting effect on the growth of fibroblasts and the synthesis of collagen, and is beneficial to the repair and tissue regeneration of wounds;
The calcium carbonate can be used as a filler to improve the physical properties of the inorganic dressing, such as increasing the hardness, toughness and stability of the dressing, so that the dressing is easier to process, form and use, and simultaneously, the air permeability and the moisture permeability of the dressing can be adjusted, so that the wound can breathe, and the wound healing is facilitated.
The medical white vaseline has good moisturizing performance, can form a layer of protective film on the surface of skin, reduces the loss of moisture of wounds, prevents the wounds from drying and crusting, is beneficial to wound healing, and can play a role in lubricating, prevent the dressing from adhering to the surface of the wounds and reduce the irritation and secondary damage to the wounds during dressing change;
the medical white vaseline can be used as a physical barrier, can isolate a wound from the external environment, prevents pollutants such as bacteria, dust and the like from contacting the wound, reduces the risk of wound infection, and can also reduce the friction of the external environment to the wound, thereby providing a relatively stable and safe environment for wound healing.
If the inorganic dressing contains some therapeutic drugs, the medical white vaseline can help the drugs to be uniformly distributed on the surface of the wound and be slowly released, so that the acting time of the drugs is prolonged, the drugs are promoted to be better absorbed by wound tissues, and the therapeutic effect of the drugs is enhanced.
Meanwhile, the chitosan molecule chain contains a large amount of amino (-NH 2) to be positive, so that negative charge substances in wound exudates, such as bacterial endotoxin and inflammatory factors, can be adsorbed by electrostatic action to form complementation with physical adsorption of silicon dioxide; the chitosan can destroy the integrity of bacterial cell membranes, inhibit the metabolic activity of the bacterial cell membranes, has broad-spectrum antibacterial action on common pathogenic bacteria such as staphylococcus aureus, escherichia coli and the like, and the physical barrier of the silica forms a protective film which is combined with a chemical antibacterial mechanism of the chitosan, so that a double antibacterial system of physical barrier and chemical bacteriostasis can be constructed, and the infection risk is obviously reduced;
in addition, the chitosan can dissociate H + in an acidic environment, has certain buffer capacity, forms dynamic balance with the alkaline neutralization effect of calcium carbonate, more accurately maintains the pH value of a wound to be weak alkaline, neutralizes acidic substances of exudates, prevents the pH value from being excessively increased, cooperatively avoids the problem of hysteresis or excessive regulation of single component regulation, can promote fibroblast proliferation and collagen synthesis, simultaneously releases calcium ions, accelerates coagulation and tissue regeneration together with calcium provided by the calcium carbonate, accelerates hemostasis by activating coagulation factors, and promotes wound repair by biocompatibility and cell affinity, and can shorten hemostasis time and accelerate epithelialization process by combining the calcium carbonate with the calcium carbonate.
Preferably, the addition amount of the silicon dioxide is 5-15% of the total mass of the dressing, and the addition amount of the calcium carbonate is 3-10% of the total mass of the dressing.
The proportion of the silicon dioxide and the calcium carbonate is optimized, the optimal balance between the adsorption performance and the pH adjusting capability is ensured, and the increase of the hardness or the decrease of the air permeability of the dressing caused by excessive amount is avoided.
Preferably, the gram weight of the spun-laced non-woven fabric is 30-60g/m 2, and the fiber porosity is 40-70%.
By controlling the gram weight and the porosity of the spunlaced non-woven fabric, the liquid absorbing capacity, the air permeability and the anti-blocking property of the spunlaced non-woven fabric are enhanced, and the use comfort of patients is improved.
Preferably, the mass ratio of the medical white vaseline to the liquid paraffin is 1:2, and the total addition amount of the medical white vaseline and the liquid paraffin is 20-30% of the total mass of the dressing.
Optimizing lubrication and moisture retention properties, preventing the dressing from adhering to the wound surface, maintaining proper moisture permeability, and avoiding excessive dryness or wetness of the wound.
The invention provides a preparation method of the dressing for non-chronic wound care of the body surface, which comprises the following steps:
(1) Mixing silicon dioxide and calcium carbonate in proportion, and grinding until uniformity is achieved;
(2) Heating medical white vaseline and liquid paraffin to 60-80 ℃, stirring and mixing, and adding the mixture obtained in the step (1) to form a pasty matrix;
(3) Uniformly coating the pasty matrix on the surface of medical absorbent gauze or spunlaced non-woven fabric, cooling, shaping, cutting and packaging.
Through the stepwise mixing and coating process, the components are ensured to be uniformly distributed, and the adsorption, lubrication and mechanical properties of the dressing are maintained.
Preferably, the heating temperature in step (2) is 70 ℃, the stirring speed is 200-400rpm, and the stirring time is 30-60 minutes.
The temperature and stirring parameters are accurately controlled, so that the decomposition or agglomeration of components is avoided, and the stability of the pasty matrix is improved.
The invention provides application of a body surface non-chronic wound care dressing in body surface non-chronic wound care, wherein the wound comprises abrasion, incised wound or burn.
Preferably, the dressing is replaced once daily without cleaning the wound surface.
The dressing change frequency and the operation complexity are reduced, the risk of secondary injury is reduced, and the compliance of patients is improved.
The invention has the beneficial effects that:
The medical white vaseline and the liquid paraffin optimize the moisturizing and slipping performance, avoid the dressing from adhering to the wound, maintain the proper wetting of the wound and create good conditions for healing, reasonable component combination also enhances the mechanical stability of the dressing, is convenient to use, is replaced once a day and does not need to clean the use mode of the wound surface, reduces the dressing changing frequency and the operation complexity, reduces the secondary injury risk, improves the patient compliance and finally promotes the quick healing of the wound.
Detailed Description
All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The dressing for non-chronic wound care on the body surface consists of the following components, wherein the addition amount of silicon dioxide is 5% of the total mass of the dressing, the specific surface area is 300m 2/g, the porosity is 70%, the addition amount of calcium carbonate is 3% of the total mass of the dressing, the particle size is 5 mu m, the mass ratio of medical white vaseline to medical liquid paraffin is 1:2, the total addition amount is 20% of the total mass of the dressing, the addition amount of chitosan is 3% of the total mass of the dressing, and the water-jet non-woven fabric with gram weight of 30g/m 2 and fiber porosity of 40% is selected.
The preparation method of the dressing for non-chronic wound care on the body surface provided by the first embodiment comprises the following steps:
(1) Mixing silicon dioxide, chitosan and calcium carbonate in proportion, and grinding to uniformity;
(2) Heating medical white vaseline and liquid paraffin to 60-80 ℃, stirring and mixing, adding the mixture obtained in the step (1), heating to 70 ℃, stirring at 200rpm for 30 minutes, and forming a pasty matrix;
(3) Uniformly coating the pasty matrix on the surface of medical absorbent gauze or spunlaced non-woven fabric, cooling, shaping, cutting and packaging.
Example two
The dressing for non-chronic wound care on the body surface consists of the following components, wherein the addition amount of silicon dioxide is 10% of the total mass of the dressing, the specific surface area is 400m 2/g, the porosity is 80%, the addition amount of calcium carbonate is 6% of the total mass of the dressing, the particle size is 7 mu m, the mass ratio of medical white vaseline to medical liquid paraffin is 1:2, the total addition amount is 25% of the total mass of the dressing, the addition amount of chitosan is 3% of the total mass of the dressing, and the spun-laced non-woven fabric with the gram weight of 45g/m 2 and the fiber porosity of 55% is selected.
The preparation method of the body surface non-chronic wound care dressing provided by the second embodiment comprises the following steps:
(1) Mixing silicon dioxide, chitosan and calcium carbonate in proportion, and grinding to uniformity;
(2) Heating medical white vaseline and liquid paraffin to 60-80 ℃, stirring and mixing, adding the mixture obtained in the step (1), heating to 70 ℃, stirring at 300rpm for 45 minutes, and forming a pasty matrix;
(3) Uniformly coating the pasty matrix on the surface of medical absorbent gauze or spunlaced non-woven fabric, cooling, shaping, cutting and packaging.
Example III
The body surface non-chronic wound care dressing provided by the third embodiment is composed of the following components of silicon dioxide with the addition amount of 15% of the total mass of the dressing, the specific surface area of 500m 2/g, the porosity of 90%, calcium carbonate with the addition amount of 10% of the total mass of the dressing and the particle size of 10 mu m, medical white vaseline and medical liquid paraffin with the mass ratio of 1:2, the total addition amount of 30% of the total mass of the dressing, chitosan with the addition amount of 3% of the total mass of the dressing, and spun-laced non-woven fabric with the gram weight of 60g/m 2 and the fiber porosity of 70%.
The preparation method of the body surface non-chronic wound care dressing provided by the third embodiment comprises the following steps:
(1) Mixing silicon dioxide, chitosan and calcium carbonate in proportion, and grinding to uniformity;
(2) Heating medical white vaseline and liquid paraffin to 60-80 ℃, stirring and mixing, adding the mixture obtained in the step (1), heating to 70 ℃, stirring at 400rpm for 60 minutes, and forming a pasty matrix;
(3) Uniformly coating the pasty matrix on the surface of medical absorbent gauze or spunlaced non-woven fabric, cooling, shaping, cutting and packaging.
Example IV
The non-chronic wound care dressing for the body surface consists of silicon dioxide, calcium carbonate, medical white vaseline and medical liquid paraffin, wherein the addition amount of the silicon dioxide is 8% of the total mass of the dressing, the specific surface area is 350m 2/g, the porosity is 75%, the addition amount of the calcium carbonate is 5% of the total mass of the dressing, the particle size is 3 mu m, the mass ratio of the medical white vaseline to the medical liquid paraffin is 1:1, the total addition amount is 22% of the total mass of the dressing, and the addition amount of the chitosan is 3% of the total mass of the dressing, and medical absorbent gauze is selected.
The preparation method of the dressing for non-chronic wound care on the body surface provided by the fourth embodiment comprises the following steps:
(1) Mixing silicon dioxide, chitosan and calcium carbonate in proportion, and grinding to uniformity;
(2) Heating medical white vaseline and liquid paraffin to 60-80 ℃, stirring and mixing, adding the mixture obtained in the step (1), heating to 60 ℃, stirring at the speed of 250rpm, and stirring for 40 minutes to form a pasty matrix;
(3) Uniformly coating the pasty matrix on the surface of medical absorbent gauze or spunlaced non-woven fabric, cooling, shaping, cutting and packaging.
Example five
The non-chronic wound care dressing for the body surface consists of silicon dioxide, calcium carbonate, medical white vaseline and medical liquid paraffin, wherein the addition amount of the silicon dioxide is 12% of the total mass of the dressing, the specific surface area is 450m 2/g, the porosity is 85%, the addition amount of the calcium carbonate is 8% of the total mass of the dressing, the particle size is 8 mu m, the mass ratio of the medical white vaseline to the medical liquid paraffin is 1:3, the total addition amount of the medical white vaseline to the medical liquid paraffin is 28% of the total mass of the dressing, and the addition amount of the chitosan is 3% of the total mass of the dressing.
The fifth embodiment provides a preparation method of a body surface non-chronic wound care dressing, which comprises the following steps:
(1) Mixing silicon dioxide, chitosan and calcium carbonate in proportion, and grinding to uniformity;
(2) Heating medical white vaseline and liquid paraffin to 60-80 ℃, stirring and mixing, adding the mixture obtained in the step (1), heating to 80 ℃, stirring at 350rpm for 50 minutes, and forming a pasty matrix;
(3) Uniformly coating the pasty matrix on the surface of medical absorbent gauze or spunlaced non-woven fabric, cooling, shaping, cutting and packaging.
Comparative example one the silica addition was reduced to 3% and the other ingredients and preparation parameters were the same as in example two.
Comparative example II calcium carbonate particle size was increased to 15. Mu.m, and other components and preparation parameters were the same as in example III.
Comparative example III the mass ratio of medical white vaseline to medical liquid paraffin is changed to 1:4, and other components and preparation parameters are the same as in example IV.
In the fourth comparative example, a spunlaced nonwoven fabric with a gram weight of 20g/m 2 and a fiber porosity of 30% is selected, and other components and preparation parameters are the same as in the first example.
Comparative example five no calcium carbonate was added and other ingredients and preparation parameters were the same as in example two.
Comparative example six a conventional gauze (low grammage, low porosity similar to comparative example four) was used as dressing, other ingredients and preparation parameters were the same as in example one, but the nonwoven fabric designed according to the invention was not used.
Test mode
And (3) performing adsorption performance test on the exudates, namely taking a dressing with a certain area, placing the dressing on the surface of simulated wound exudates (mixed solution of physiological saline and protein), soaking for 10 minutes, taking out the dressing, sucking superfluous liquid on the surface by using filter paper, and weighing to calculate the adsorption quantity.
Antibacterial property test, namely placing the dressing on an agar plate inoculated with common wound infection bacteria (such as staphylococcus aureus and escherichia coli) by adopting an agar diffusion method, and measuring the diameter of a bacteriostasis ring after culturing for 24 hours.
Moisture retention performance test the dressing was placed in a humidity environment (50% relative humidity), weighed every 2 hours, and the moisture loss rate was calculated.
Effect of calcium carbonate on pH adjustment test several groups of simulated wound exudate samples were prepared, each group having the same volume and 100mL, with initial pH adjusted to 5.5-6.5 (simulated wound exudate slightly acidic environment).
The dressings of the different examples and comparative examples were cut to the same area (5 cm. Times.5 cm) and placed in simulated wound exudate samples, respectively.
Standing at 37 ℃ in a constant temperature environment, measuring the pH value of the exudates at intervals of 1 hour by using a pH meter, and recording the change of the pH value within 24 hours.
And (3) testing the influence of the gram weight of the non-woven fabric on the air permeability, namely calibrating by using an air permeability tester according to the operation instruction of the instrument.
The nonwoven fabrics used in the different examples and comparative examples were cut to standard test sizes (circles with a diameter of 70 mm).
The nonwoven fabric sample was mounted on a permeability tester, the test pressure was set at 500Pa, the air flow rate per unit time through the nonwoven fabric per unit area was measured, and data was recorded in units of L/(m 2. Multidot.s).
Test of the effect of dressing on wound healing time 60 healthy adult SD rats were selected and circular cut wounds of the same size (about 1.5cm diameter) were made in their backs.
Rats were randomly divided into 10 groups of 6 rats each. Dressing treatments were performed using the dressings of examples 1-5 and comparative examples 1-5, respectively, and the group of comparative example 6 was dressing with ordinary gauze.
Wound healing was observed daily and the time to complete epithelialization of the wound (complete coverage of the wound surface with new epithelium) was recorded to the nearest day.
Dressing change frequency effects on patient comfort test 60 non-chronic wound patients (wound types including bruises, cuts, shallow burns, etc.) were recruited and randomized into 6 groups of 10 people each.
The dressing of example 2 was used for each of 6 groups of patients, and the treatment was performed at different dressing change frequencies, 1 time per day for group A, 1 time per day for group B, 1 time per day for group C, 1 time per day for group 3, 1 time per day for group D, 1 time per day for group E, 1 time per day for group 5, and 1 time per day for group F.
At each change, the patient was scored for pain level during the change using Visual Analog Scoring (VAS) (0 for no pain and 10 for severe pain) and asked for the patient's acceptance of the frequency of the change (five grades of very satisfactory, general, unsatisfactory, very unsatisfactory) and the data was recorded.
The above test data are summarized in table 1 below.
TABLE 1 dressing test data summary table
From the example data, as the amount of silica and calcium carbonate added increases, the amount of exudate adsorbed, antibacterial properties, and pH adjusting ability are on the rise, as in examples one to three. However, when the amount of silica added is too small (comparative example one), the adsorption and antibacterial properties are significantly reduced, and when the particle size of calcium carbonate is too large (comparative example two), the effect of the calcium carbonate in the dressing is affected, resulting in a reduction in part of the properties. Without the addition of calcium carbonate (comparative example five), the pH adjusting ability was significantly reduced.
The increase of the gram weight and the porosity of the spun-laced non-woven fabric improves the tensile strength and the air permeability of the dressing, improves the adsorption performance and the moisture retention performance to a certain extent, and has the best performance in the third embodiment. The non-woven fabric with low gram weight and small porosity (comparative example IV) can deteriorate various properties of the dressing, especially air permeability and mechanical properties, and the comprehensive properties of common gauze (comparative example VI) are far lower than those of the dressing designed by the invention.
The dressing of example was effective in shortening the time to wound healing compared to the comparative example, with the third example having the shortest time to healing. In the test of the influence of the dressing change frequency on the comfort of the patient, when the dressing change is carried out 1 time per day (examples one to five), the overall satisfaction of the patient is higher, as the dressing change frequency is reduced (as in the comparative example), the VAS score is increased, the satisfaction of the patient is reduced, and the reasonable dressing change frequency is indicated to be helpful for improving the comfort of the patient and the treatment compliance.
The foregoing description of the preferred embodiments of the invention is not intended to limit the invention to the precise form disclosed, and any such modifications, equivalents, and alternatives falling within the spirit and principles of the invention are intended to be included within the scope of the invention.

Claims (8)

1. A dressing for non-chronic wound care on a body surface is characterized by comprising the following components of silicon dioxide, calcium carbonate, medical white vaseline, medical liquid paraffin, chitosan and medical absorbent gauze or spunlaced non-woven fabric, wherein the specific surface area of the silicon dioxide is 200-500m 2/g, the porosity is 60-90%, the particle size of the calcium carbonate is 1-10 mu m, and the mass ratio of the medical white vaseline to the medical liquid paraffin is 1:1-1:3;
the addition amount of the calcium carbonate is 3-10% of the total mass of the dressing.
2. The non-chronic wound care dressing according to claim 1, wherein the silica is added in an amount of 5-15% of the total mass of the dressing, and the chitosan is added in an amount of 2-5% of the total mass of the dressing.
3. The non-chronic wound care dressing according to claim 1, wherein the spunlaced nonwoven fabric has a grammage of 30-60g/m 2 and a fiber porosity of 40-70%.
4. The dressing according to claim 1, wherein the mass ratio of the medical white vaseline to the liquid paraffin is 1:2, and the total addition amount of the medical white vaseline and the liquid paraffin is 20-30% of the total mass of the dressing.
5. A method of preparing a body surface non-chronic wound care dressing according to any one of claims 1 to 4, comprising the steps of:
(1) Mixing silicon dioxide, chitosan and calcium carbonate in proportion, and grinding to uniformity;
(2) Heating medical white vaseline and liquid paraffin to 60-80 ℃, stirring and mixing, and adding the mixture obtained in the step (1) to form a pasty matrix;
(3) Uniformly coating the pasty matrix on the surface of medical absorbent gauze or spunlaced non-woven fabric, cooling, shaping, cutting and packaging.
6. The method of claim 5, wherein the heating temperature in step (2) is 70 ℃, the stirring rate is 200-400rpm, and the stirring time is 30-60 minutes.
7. Use of a body surface non-chronic wound care dressing according to any of claims 1-4 in body surface non-chronic wound care, wherein the wound comprises an abrasion, cut or burn.
8. The use of a non-chronic wound care dressing according to claim 7, wherein the dressing is replaced once daily without cleaning the wound surface.
CN202510714106.6A 2025-05-30 2025-05-30 A dressing for caring for non-chronic wounds on body surface, preparation method and application thereof Pending CN120571048A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510714106.6A CN120571048A (en) 2025-05-30 2025-05-30 A dressing for caring for non-chronic wounds on body surface, preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202510714106.6A CN120571048A (en) 2025-05-30 2025-05-30 A dressing for caring for non-chronic wounds on body surface, preparation method and application thereof

Publications (1)

Publication Number Publication Date
CN120571048A true CN120571048A (en) 2025-09-02

Family

ID=96859206

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202510714106.6A Pending CN120571048A (en) 2025-05-30 2025-05-30 A dressing for caring for non-chronic wounds on body surface, preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN120571048A (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100021528A1 (en) * 2006-09-20 2010-01-28 Entek Manufacturing Inc. Conformable structured therapeutic dressing
CN103357061A (en) * 2013-06-24 2013-10-23 扬州辐照中心 Production method of surgical dressing by irradiation sterilization
CN104258453A (en) * 2014-09-24 2015-01-07 湖北华中医用材料有限公司 Raw material composition of active wound repair material and preparation method of raw material composition
CN104623718A (en) * 2015-01-22 2015-05-20 谈伟强 Chitosan petrolatum gauze and preparation method thereof
CN107693833A (en) * 2017-10-18 2018-02-16 张家港蓝智生物科技有限公司 A kind of dispel scar moist dressing and preparation method containing bioactivity glass
CN112409777A (en) * 2020-11-09 2021-02-26 江苏鑫易达新材料科技有限公司 Medical antibacterial breathable TPU film and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100021528A1 (en) * 2006-09-20 2010-01-28 Entek Manufacturing Inc. Conformable structured therapeutic dressing
CN103357061A (en) * 2013-06-24 2013-10-23 扬州辐照中心 Production method of surgical dressing by irradiation sterilization
CN104258453A (en) * 2014-09-24 2015-01-07 湖北华中医用材料有限公司 Raw material composition of active wound repair material and preparation method of raw material composition
CN104623718A (en) * 2015-01-22 2015-05-20 谈伟强 Chitosan petrolatum gauze and preparation method thereof
CN107693833A (en) * 2017-10-18 2018-02-16 张家港蓝智生物科技有限公司 A kind of dispel scar moist dressing and preparation method containing bioactivity glass
CN112409777A (en) * 2020-11-09 2021-02-26 江苏鑫易达新材料科技有限公司 Medical antibacterial breathable TPU film and preparation method thereof

Similar Documents

Publication Publication Date Title
Ingle et al. Wound healing with honey-a randomised controlled trial
Dowsett The use of silver-based dressings in wound care
Shyna et al. A nonadherent chitosan-polyvinyl alcohol absorbent wound dressing prepared via controlled freeze-dry technology
Vanstraelen Comparison of calcium sodium alginate (KALTOSTAT) and porcine xenograft (EZ DERM) in the healing of split-thickness skin graft donor sites
EP3695855A1 (en) Alginate wound repair dressing and preparation method thereof
WO2000001424A1 (en) Wound-covering preparation, wound-covering material, and method of wound healing
US20060211972A1 (en) Wound dressing
CN101249274A (en) Preparation and application of bletilla striata polysaccharide hydrogel for promoting wound healing
CN101721691A (en) Preparation for treating and restoring infective wound surface and preparation method thereof
JP2009528099A (en) Wound dressing comprising an anti-inflammatory analgesic and a complex of silver ions and group IV transition elements of the periodic table
CN110025813A (en) A kind of wound depth reparative regeneration dressing formula and preparation method
JP2010527673A (en) Novel active ingredients and their use in fusion
CN111097067A (en) A kind of antibacterial medical dressing for promoting rapid wound healing and preparation method thereof
RU2372944C2 (en) Wound healing coating
Saco et al. Postoperative Pain Management in
Jung et al. In vitro evaluation of betafoam, a new polyurethane foam dressing
Burd Evaluating the use of hydrogel sheet dressings in comprehensive burn wound care
Liu et al. Application of crystalline cellulose membrane (Veloderm®) on split-thickness skin graft donor sites in burn or reconstructive plastic surgery patients
NO162894B (en) PROCEDURE FOR THE PREPARATION OF A COMPRESSION CONTAINING AIR CLEANING WOUND AND STIMULATING FOR HEALING.
CN112656988A (en) Hydrogel dressing and dressing patch
WO2012066447A1 (en) Compositions with antibacterial and wound healing activity
CN115770318A (en) Composite porous hemostatic plaster and application thereof
Price et al. A study to evaluate primary dressings for the application of cultured keratinocytes
CN120571048A (en) A dressing for caring for non-chronic wounds on body surface, preparation method and application thereof
US20250127954A1 (en) Three-dimensional network aqueous gel and manufacturing method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination