Disclosure of Invention
In view of the above, the invention aims to provide a traditional Chinese medicine composition, a curing patch and a preparation method thereof, which are improved from the aspects of a formula and an extraction process, and the improvement effect on reproductive health is improved.
In order to achieve the above object, the present invention has the following technical scheme:
On the one hand, the invention provides a traditional Chinese medicine composition, which comprises the following raw materials, by weight, 10-30 parts of snow lotus herb, 10-30 parts of safflower, 10-30 parts of white peony root, 5-25 parts of cistanche, 1-10 parts of glabrous greenbrier rhizome, 5-15 parts of motherwort herb, 1-10 parts of phellinus linteus, 1-10 parts of amur corktree bark, 1-5 parts of nutgrass galingale rhizome, 1-5 parts of wild jujube seed, 1-10 parts of common anemarrhena rhizome and 5-20 parts of peony root.
Preferably, the traditional Chinese medicine composition comprises, by weight, 15-25 parts of snow lotus herb, 15-25 parts of safflower, 15-25 parts of white peony root, 10-20 parts of cistanche, 3-8 parts of glabrous greenbrier rhizome, 8-12 parts of motherwort herb, 3-8 parts of Phellinus linteus, 3-8 parts of phellodendron bark, 2-4 parts of nutgrass galingale rhizome, 2-4 parts of wild jujube seed, 3-8 parts of rhizoma anemarrhenae and 10-15 parts of peony root.
Further preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20 parts of snow lotus herb, 20 parts of safflower, 20 parts of white peony root, 15 parts of cistanche, 5 parts of glabrous greenbrier rhizome, 10 parts of motherwort herb, 5 parts of Phellinus linteus, 5 parts of amur corktree bark, 3 parts of nutgrass galingale rhizome, 3 parts of wild jujube seed, 6 parts of common anemarrhena rhizome and 12 parts of tree peony root.
In still another aspect, the present invention provides a method for preparing the above-mentioned Chinese medicinal composition, comprising the steps of:
(1) Distilling herba Saussureae Involueratae and Carthami flos to obtain volatile oil;
(2) Pulverizing radix Paeoniae alba, herba cistanches, rhizoma Smilacis Glabrae, herba Leonuri, phellinus linteus, cortex Phellodendri, rhizoma anemarrhenae, and radix moutan, mixing, extracting with water for 1-4 times, mixing the extractive solutions, and concentrating to obtain extract;
(3) Pulverizing rhizoma Cyperi and semen Ziziphi Spinosae to obtain medicinal powder;
(4) And (3) uniformly mixing the medicinal powder obtained in the step (3) with the volatile oil obtained in the step (1) and the extract obtained in the step (2) to obtain the traditional Chinese medicine composition.
Preferably, in step (1), the distillation extraction time is 0.5 to 2 hours, more preferably 1 hour.
Preferably, in step (2), the water is added for 2 times.
Further preferably, the condition of water adding and extraction is that water with the weight of 5-20 times of that of the medicinal materials is added each time, and the water is decocted and extracted for 0.5-1.5 hours, and further preferably, water with the weight of 10 times of that of the medicinal materials is added each time, and the water is decocted and extracted for 50 minutes.
Preferably, in step (2), the concentration is such that the extract is concentrated to a density of 1.1-1.5, more preferably 1.2-1.3.
Preferably, in step (3), the pulverization is ultrafine pulverization.
In still another aspect, the present invention provides a patch comprising an active ingredient and a patch carrier,
The active ingredients are the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method,
The curing patch carrier may use a patch carrier conventional in the art, and as a specific example of the present invention, the curing patch carrier includes pure cotton knitted fabric, a breathable film, an adhesive pure cotton knitted fabric, and dust-free paper.
Further, as a specific example of the present invention, the curing patch has a structure as shown in fig. 1.
Finally, the invention provides a preparation method of the maintenance patch, which comprises the following steps:
packaging the effective components in a maintenance patch carrier.
The drug loading rate of the maintenance patch is 8-15 g/patch, and more preferably 10 g/patch.
The beneficial effects of the invention are as follows:
The maintenance patch is prepared by taking a formula of snow lotus herb, safflower, white peony root, cistanche, glabrous greenbrier rhizome, borneol, motherwort herb, phellinus linteus, amur corktree bark, nutgrass galingale rhizome, wild jujube seed, common anemarrhena rhizome and tree peony root as active ingredients, extracting snow lotus herb and safflower to obtain volatile oil, extracting white peony root, cistanche, glabrous greenbrier rhizome, motherwort herb, phellinus linteus, amur corktree bark, common anemarrhena rhizome and tree peony root with water, and grinding nutgrass galingale rhizome and wild jujube seed to obtain the traditional Chinese medicine composition.
Detailed Description
In order to make the technical means, the creation features, the achievement of the purpose and the effect of the present invention easy to understand, the present invention will be further elucidated with reference to the specific embodiments, but the following embodiments are only preferred embodiments of the present invention, not all of them. Based on the examples in the embodiments, those skilled in the art can obtain other examples without making any inventive effort, which fall within the scope of the invention. In the following examples, unless otherwise specified, the methods of operation used were conventional, the equipment used was conventional, and the materials used in the examples were the same.
Example 1
The raw material formula comprises 20 parts of snow lotus herb, 20 parts of safflower, 20 parts of white peony root, 15 parts of cistanche, 5 parts of glabrous greenbrier rhizome, 10 parts of motherwort herb, 5 parts of Phellinus linteus, 5 parts of amur corktree bark, 3 parts of nutgrass galingale rhizome, 3 parts of wild jujube seed, 6 parts of common anemarrhena rhizome and 12 parts of peony root.
Preparing a traditional Chinese medicine composition:
(1) Distilling herba Saussureae Involueratae and Carthami flos of formula amount for 1 hr to obtain volatile oil;
(2) Pulverizing radix Paeoniae alba, herba cistanches, rhizoma Smilacis Glabrae, herba Leonuri, phellinus linteus, cortex Phellodendri, herba cistanches, rhizoma anemarrhenae, and radix moutan, mixing, extracting with water for 2 times, adding water 10 times the weight of the materials each time, decocting for 50min, mixing the two extractive solutions, and concentrating to density of 1.3 to obtain extract;
(3) Micronizing rhizoma Cyperi and semen Ziziphi Spinosae to obtain medicinal powder;
(4) And (3) uniformly mixing the medicinal powder obtained in the step (3) with the volatile oil obtained in the step (1) and the extract obtained in the step (2) to obtain the traditional Chinese medicine composition.
Preparing a curing patch:
The Chinese medicinal composition is packaged in a maintenance patch carrier with the structure shown in figure 1 to obtain maintenance patch.
Example 2
The raw material formula comprises 15 parts of snow lotus herb, 25 parts of safflower, 15 parts of white peony root, 20 parts of cistanche, 3 parts of glabrous greenbrier rhizome, 8 parts of motherwort herb, 8 parts of Phellinus linteus, 8 parts of amur corktree bark, 2 parts of nutgrass galingale rhizome, 4 parts of wild jujube seed, 3 parts of common anemarrhena rhizome and 15 parts of tree peony root.
Preparing a traditional Chinese medicine composition:
(1) Distilling herba Saussureae Involueratae and Carthami flos of formula amount for 1 hr to obtain volatile oil;
(2) Pulverizing radix Paeoniae alba, herba cistanches, rhizoma Smilacis Glabrae, herba Leonuri, phellinus linteus, cortex Phellodendri, herba cistanches, rhizoma anemarrhenae, and radix moutan, mixing, extracting with water for 2 times, adding water 10 times the weight of the materials each time, decocting for 50min, mixing the two extractive solutions, and concentrating to density of 1.3 to obtain extract;
(3) Micronizing rhizoma Cyperi and semen Ziziphi Spinosae to obtain medicinal powder;
(4) And (3) uniformly mixing the medicinal powder obtained in the step (3) with the volatile oil obtained in the step (1) and the extract obtained in the step (2) to obtain the traditional Chinese medicine composition.
Preparing a curing patch:
The Chinese medicinal composition is packaged in a maintenance patch carrier with the structure shown in figure 1 to obtain maintenance patch.
Example 3
The raw material formula comprises 25 parts of snow lotus herb, 15 parts of safflower, 25 parts of white peony root, 10 parts of cistanche, 8 parts of glabrous greenbrier rhizome, 12 parts of motherwort herb, 3 parts of Phellinus linteus, 3 parts of amur corktree bark, 4 parts of nutgrass galingale rhizome, 4 parts of wild jujube seed, 8 parts of common anemarrhena rhizome and 10 parts of tree peony root.
Preparing a traditional Chinese medicine composition:
(1) Distilling herba Saussureae Involueratae and Carthami flos of formula amount for 1 hr to obtain volatile oil;
(2) Pulverizing radix Paeoniae alba, herba cistanches, rhizoma Smilacis Glabrae, herba Leonuri, phellinus linteus, cortex Phellodendri, herba cistanches, rhizoma anemarrhenae, and radix moutan, mixing, extracting with water for 2 times, adding water 10 times the weight of the materials each time, decocting for 50min, mixing the two extractive solutions, and concentrating to density of 1.2 to obtain extract;
(3) Micronizing rhizoma Cyperi and semen Ziziphi Spinosae to obtain medicinal powder;
(4) And (3) uniformly mixing the medicinal powder obtained in the step (3) with the volatile oil obtained in the step (1) and the extract obtained in the step (2) to obtain the traditional Chinese medicine composition.
Preparing a curing patch:
The Chinese medicinal composition is packaged in a maintenance patch carrier with the structure shown in figure 1 to obtain maintenance patch.
Example 4
The raw material formula comprises 10 parts of snow lotus herb, 30 parts of safflower, 10 parts of white peony root, 5 parts of cistanche, 10 parts of glabrous greenbrier rhizome, 15 parts of motherwort herb, 10 parts of phellinus linteus, 1 part of amur corktree bark, 1 part of nutgrass galingale rhizome, 5 parts of wild jujube seed, 10 parts of common anemarrhena rhizome and 5 parts of tree peony root.
Preparing a traditional Chinese medicine composition:
(1) Distilling herba Saussureae Involueratae and Carthami flos of formula amount for 1 hr to obtain volatile oil;
(2) Pulverizing radix Paeoniae alba, herba cistanches, rhizoma Smilacis Glabrae, herba Leonuri, phellinus linteus, cortex Phellodendri, herba cistanches, rhizoma anemarrhenae, and radix moutan, mixing, extracting with water for 2 times, adding water 10 times the weight of the materials each time, decocting for 50min, mixing the two extractive solutions, and concentrating to density of 1.2 to obtain extract;
(3) Micronizing rhizoma Cyperi and semen Ziziphi Spinosae to obtain medicinal powder;
(4) And (3) uniformly mixing the medicinal powder obtained in the step (3) with the volatile oil obtained in the step (1) and the extract obtained in the step (2) to obtain the traditional Chinese medicine composition.
Preparing a curing patch:
The Chinese medicinal composition is packaged in a maintenance patch carrier with the structure shown in figure 1 to obtain maintenance patch.
Example 5
The raw material formula comprises 30 parts of snow lotus herb, 10 parts of safflower, 30 parts of white peony root, 25 parts of cistanche, 1 part of glabrous greenbrier rhizome, 5 parts of motherwort herb, 1 part of Phellinus linteus, 10 parts of amur corktree bark, 5 parts of nutgrass galingale rhizome, 1 part of wild jujube seed, 1 part of common anemarrhena rhizome and 20 parts of tree peony root.
Preparing a traditional Chinese medicine composition:
(1) Distilling herba Saussureae Involueratae and Carthami flos of formula amount for 2 hr to obtain volatile oil;
(2) Pulverizing radix Paeoniae alba, herba cistanches, rhizoma Smilacis Glabrae, herba Leonuri, phellinus linteus, cortex Phellodendri, herba cistanches, rhizoma anemarrhenae, and radix moutan, mixing, extracting with water for 2 times, adding water 10 times the weight of the materials each time, decocting for 50min, mixing the two extractive solutions, and concentrating to density of 1.3 to obtain extract;
(3) Micronizing rhizoma Cyperi and semen Ziziphi Spinosae to obtain medicinal powder;
(4) And (3) uniformly mixing the medicinal powder obtained in the step (3) with the volatile oil obtained in the step (1) and the extract obtained in the step (2) to obtain the traditional Chinese medicine composition.
Preparing a curing patch:
The Chinese medicinal composition is packaged in a maintenance patch carrier with the structure shown in figure 1 to obtain maintenance patch.
Comparative example 1
The raw material formula comprises 40 parts of snow lotus herb, 5 parts of safflower, 5 parts of white peony root, 30 parts of cistanche, 1 part of glabrous greenbrier rhizome, 20 parts of motherwort herb, 15 parts of phellinus linteus, 1 part of amur corktree bark, 10 parts of nutgrass galingale rhizome, 1 part of wild jujube seed, 5 parts of common anemarrhena rhizome and 3 parts of tree peony root.
The preparation method of the traditional Chinese medicine composition and the curing patch is the same as that of the example 1.
Comparative example 2
The raw material formula comprises 20 parts of snow lotus herb, 20 parts of safflower, 15 parts of cistanche, 5 parts of glabrous greenbrier rhizome, 10 parts of motherwort herb, 5 parts of phellodendron bark, 3 parts of wild jujube, 6 parts of rhizoma anemarrhenae and 12 parts of peony root.
The preparation method of the traditional Chinese medicine composition and the curing patch is the same as that of the example 1.
Comparative example 3
The raw material formula comprises 20 parts of snow lotus herb, 20 parts of safflower, 20 parts of white peony root, 15 parts of cistanche, 10 parts of motherwort herb, 5 parts of Phellinus linteus, 5 parts of phellodendron bark, 3 parts of nutgrass galingale rhizome, 3 parts of wild jujube seed and 6 parts of rhizoma anemarrhenae.
The preparation method of the traditional Chinese medicine composition and the curing patch is the same as that of the example 1.
Comparative example 4
The raw material formula comprises 20 parts of snow lotus herb, 20 parts of safflower, 20 parts of white peony root, 15 parts of prepared rehmannia root, 5 parts of glabrous greenbrier rhizome, 10 parts of motherwort herb, 5 parts of Phellinus linteus, 5 parts of amur corktree bark, 3 parts of belvedere fruit, 3 parts of red sage root, 6 parts of common anemarrhena rhizome and 12 parts of suberect spatholobus stem.
The preparation method of the traditional Chinese medicine composition and the curing patch is the same as that of the example 1.
Comparative example 5
The raw material formulation was the same as in example 1.
Preparing a traditional Chinese medicine composition:
pulverizing herba Saussureae Involueratae, carthami flos, radix Paeoniae alba, cistanchis herba, rhizoma Smilacis Glabrae, herba Leonuri, phellinus linteus, cortex Phellodendri, rhizoma Cyperi, semen Ziziphi Spinosae, cistanchis herba, rhizoma anemarrhenae, and radix moutan root, mixing, extracting with water for 2 times, adding 10 times of water for each time, decocting for 50min, mixing the two extractive solutions, and concentrating to density of 1.3 to obtain the final product.
The preparation method of the curing patch is the same as that of the example 1.
Comparative example 6
The raw material formulation was the same as in example 1.
Preparing a traditional Chinese medicine composition:
The Chinese medicinal composition is prepared by micronizing herba Saussureae Involueratae, carthami flos, radix Paeoniae alba, cistanchis herba, rhizoma Smilacis Glabrae, herba Leonuri, phellinus linteus, cortex Phellodendri, rhizoma Cyperi, semen Ziziphi Spinosae, cistanchis herba, rhizoma anemarrhenae, and radix moutan.
The preparation method of the curing patch is the same as that of the example 1.
Result detection
1. Antibacterial effect experiment
The maintenance patches prepared in examples 1 to 5 and comparative examples 1 to 5 were subjected to bacteriostasis test with reference to disposable hygienic product sanitary standard GB15979-2002, respectively, and the test bacteria were Candida albicans, staphylococcus aureus, escherichia coli, gonococcus and Lactobacillus, with the following results:
TABLE 1 antibacterial effect test results
The results show that the curing patch prepared in the embodiment 1-5 has strong inhibition effect on candida albicans, staphylococcus aureus, escherichia coli and gonococcus, has weak inhibition effect on lactobacillus (beneficial bacteria), and is beneficial to improving microenvironment of reproductive systems. In comparative examples 1 to 4, the antibacterial effect of the traditional Chinese medicine composition is obviously reduced by changing the raw material formulas of different traditional Chinese medicine compositions, and in comparative examples 5 and 6, water extraction or superfine grinding is uniformly carried out, the traditional Chinese medicine composition is not extracted according to the characteristics of medicinal materials, and the antibacterial performance is reduced to different degrees.
2. Irritation test
The experimental animal is rabbit;
The samples to be tested are the traditional Chinese medicine compositions prepared in the examples 1-5 and the comparative examples 1-5;
the experimental method comprises the following steps:
(1) Skin irritation, namely, mao Qudiao on two sides of the spine of the back of a rabbit is smeared on dehaired skin on one side 24 hours before the test, the smearing area is 2.5cm multiplied by 2.5cm, gauze is adopted for wrapping, water is used for cleaning after 4 hours, residues are removed, the operation is repeated once a day, and the result is observed after 14 days;
(2) The vaginal mucosa stimulation comprises wetting the catheter, inserting into rabbit vagina with insertion depth of 4-5cm, slowly injecting 2mL sample to be tested, extracting the catheter, repeating the above operation once daily for 5 days, killing at 24 hr interval after the last operation, taking complete vagina, and observing the result.
Negative, no adverse reaction;
positive, the irritation reaction such as redness, pimple, speckle, congestion of vaginal mucosa, and edema.
The results were as follows:
TABLE 2 results of irritation experiments
The results show that the traditional Chinese medicine compositions of examples 1-5 and comparative examples 1-3 and 6 have no irritation effect on skin and vaginal mucosa, and the traditional Chinese medicine compositions of comparative examples 4 and 5 have irritation response on vaginal mucosa.
3. Typical cases
1. According to the prescription, a woman ages at 33 years, the symptoms are itching and dryness of the private part, meanwhile, the body is heavy in moisture, the symptoms of cold womb and dysmenorrhea are accompanied, the patient wears the maintenance patch prepared in the embodiment 1 (in particular to the private part stuck to the inner layer of underpants), the maintenance patch is replaced once a day, the menstrual period is stopped, the female is used for 2 months, the itching and dryness symptoms of the private part disappear, the body moisture is relieved, and the symptoms of the dysmenorrhea are obviously relieved.
2. Wang Mou women, 40 years old, infected with vulvitis for one year and half, the patient wears the curing patch prepared in example 1 (in particular, the curing patch is attached to the private part of the inner layer of underpants), changes once a day, stops the menstrual period, uses for 3 months, and the vulvitis disappears.
3. Zhang Mou A, 31 years old, the body moisture is heavy, the scrotum is wet, the patient wears the maintenance patch prepared in the example 1 (in particular to the private part of the inner layer of underpants), the patch is replaced once a day, the usage is carried out for 2 months, the body moisture is relieved, and the scrotum moisture symptom is eliminated.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.