CN120174006A - 用于通过降低内源性蛋白质的水平来改善生物产物的生产的方法 - Google Patents

用于通过降低内源性蛋白质的水平来改善生物产物的生产的方法 Download PDF

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Publication number
CN120174006A
CN120174006A CN202510267020.3A CN202510267020A CN120174006A CN 120174006 A CN120174006 A CN 120174006A CN 202510267020 A CN202510267020 A CN 202510267020A CN 120174006 A CN120174006 A CN 120174006A
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cell
product
protein
fold
production
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Chinese (zh)
Inventor
R·杨
P·M·奥卡拉汉
D·詹姆斯
S·杰夫
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Lonza AG
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Lonza AG
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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CN202510267020.3A 2018-07-13 2019-07-12 用于通过降低内源性蛋白质的水平来改善生物产物的生产的方法 Pending CN120174006A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862697480P 2018-07-13 2018-07-13
US62/697,480 2018-07-13
PCT/US2019/041615 WO2020014618A1 (en) 2018-07-13 2019-07-12 Methods for improving production of biological products by reducing the level of endogenous protein
CN201980046173.8A CN112424339B (zh) 2018-07-13 2019-07-12 用于通过降低内源性蛋白质的水平来改善生物产物的生产的方法

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CN201980046173.8A Division CN112424339B (zh) 2018-07-13 2019-07-12 用于通过降低内源性蛋白质的水平来改善生物产物的生产的方法

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CN120174006A true CN120174006A (zh) 2025-06-20

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CN201980046173.8A Active CN112424339B (zh) 2018-07-13 2019-07-12 用于通过降低内源性蛋白质的水平来改善生物产物的生产的方法

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US (2) US12497624B2 (https=)
EP (1) EP3807399A1 (https=)
JP (2) JP7543246B2 (https=)
KR (1) KR20210030949A (https=)
CN (2) CN120174006A (https=)
IL (1) IL280086B2 (https=)
SG (1) SG11202013191TA (https=)
WO (1) WO2020014618A1 (https=)

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EP4438622A1 (en) * 2023-03-30 2024-10-02 Sartorius Stedim Cellca GmbH Cho cells with optimized ecm profile

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JP2021530225A (ja) 2021-11-11
CN112424339B (zh) 2025-03-28
EP3807399A1 (en) 2021-04-21
US20260062709A1 (en) 2026-03-05
IL280086A (en) 2021-03-01
SG11202013191TA (en) 2021-01-28
US20210324390A1 (en) 2021-10-21
IL280086B2 (en) 2026-02-01
WO2020014618A1 (en) 2020-01-16
IL280086B1 (en) 2025-10-01
US12497624B2 (en) 2025-12-16
JP7543246B2 (ja) 2024-09-02
CN112424339A (zh) 2021-02-26
KR20210030949A (ko) 2021-03-18
JP2024161560A (ja) 2024-11-19

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