CN120112282A - 包含鞘氨醇碱的用于抑制瘙痒的试剂及其用途 - Google Patents

包含鞘氨醇碱的用于抑制瘙痒的试剂及其用途 Download PDF

Info

Publication number
CN120112282A
CN120112282A CN202380077836.9A CN202380077836A CN120112282A CN 120112282 A CN120112282 A CN 120112282A CN 202380077836 A CN202380077836 A CN 202380077836A CN 120112282 A CN120112282 A CN 120112282A
Authority
CN
China
Prior art keywords
sphingosine
acid
agent
inhibiting
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380077836.9A
Other languages
English (en)
Chinese (zh)
Inventor
高桥达治
冈本知也
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ichimaru Pharcos Co Ltd
Original Assignee
Ichimaru Pharcos Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ichimaru Pharcos Co Ltd filed Critical Ichimaru Pharcos Co Ltd
Publication of CN120112282A publication Critical patent/CN120112282A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202380077836.9A 2022-11-11 2023-06-14 包含鞘氨醇碱的用于抑制瘙痒的试剂及其用途 Pending CN120112282A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022181327 2022-11-11
JP2022-181327 2022-11-11
PCT/JP2023/022157 WO2024100919A1 (ja) 2022-11-11 2023-06-14 スフィンゴイド塩基を含む掻痒抑制に用いるための剤およびその用途

Publications (1)

Publication Number Publication Date
CN120112282A true CN120112282A (zh) 2025-06-06

Family

ID=91032082

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380077836.9A Pending CN120112282A (zh) 2022-11-11 2023-06-14 包含鞘氨醇碱的用于抑制瘙痒的试剂及其用途

Country Status (3)

Country Link
JP (1) JPWO2024100919A1 (https=)
CN (1) CN120112282A (https=)
WO (1) WO2024100919A1 (https=)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002003378A (ja) * 2000-06-22 2002-01-09 Kanebo Ltd 外用抗掻痒剤
JP4383427B2 (ja) * 2006-05-16 2009-12-16 株式会社スリービー 皮膚保湿剤および皮膚炎治療剤
JPWO2016021573A1 (ja) * 2014-08-04 2017-05-25 株式会社明治 角層細胞共有結合セラミドの産生促進剤

Also Published As

Publication number Publication date
WO2024100919A1 (ja) 2024-05-16
JPWO2024100919A1 (https=) 2024-05-16

Similar Documents

Publication Publication Date Title
US11529370B2 (en) Use of composition comprising stem cell-derived exosome as effective ingredient in strengthening skin barrier and improving skin barrier function
EP3639832A2 (en) Use of composition comprising adipose stem cell-derived exosome as effective ingredient in alleviating dermatitis
EP2883548B1 (en) Filaggrin gene expression promoter
KR102045188B1 (ko) 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부염 개선 용도
JPH0585924A (ja) 皮膚外用剤
JP6786193B1 (ja) 細胞外ａｔｐ濃度上昇抑制剤
KR102039302B1 (ko) 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부장벽 강화 내지 기능 개선 용도
JP2024114037A (ja) 表皮角化細胞の角化促進に用いるための剤およびその用途
CN120112282A (zh) 包含鞘氨醇碱的用于抑制瘙痒的试剂及其用途
WO2023249046A1 (ja) ヒアルロン酸の構造を維持するための剤
JP7144878B1 (ja) エラスチン産生促進のための剤
JP7589988B2 (ja) プロテアソーム活性化剤
WO2024048489A1 (ja) レチノール様作用の誘導に用いるための剤およびその用途
JP7701773B1 (ja) ヒアルロン酸の構造維持に用いるための剤
CN115243666A (zh) 神经酰胺增殖促进剂
JP2026031357A (ja) ＡＧＥｓおよびＲＡＧＥの結合阻害に用いるための剤、皮膚塗布剤、および化粧料
CN118103041B (zh) 含有堆心菊内酯衍生物的前体脂肪细胞的增殖和/或分化促进剂
JP2025104391A (ja) Ｎｏｔｃｈ１遺伝子の発現抑制に用いるための剤およびその用途
KR102749211B1 (ko) 한방 약재의 미생물 발효 오일을 포함하는 조성물 및 그의 피부 상태 개선 용도
CN120053523A (zh) 芍药提取物在抑制AGEs-RAGE结合中的应用及含其制剂的制备方法
JP2018108973A (ja) Ｘｖｉｉ型コラーゲン産生促進剤
WO2023112717A1 (ja) Ｐａｄ１の産生促進薬剤及び新薬剤評価方法
JP2024035284A (ja) ヒアルロン酸産生促進剤
JP2023056457A (ja) 美白剤
JP2024075916A (ja) 皮膚の糖化を抑制するための剤

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination