CN119970941A - A Chinese medicine composition for treating migraine and its preparation method and application - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating migraine, and a preparation method and application thereof, belonging to the technical field of traditional Chinese medicines, and comprising the following medicinal materials of rhizoma gastrodiae, rhizoma corydalis, folium artemisiae argyi, radix codonopsis pilosulae, fructus amomi, fennel, radix linderae, caulis polygoni multiflori, cortex albiziae, radix salviae miltiorrhizae, cortex magnoliae officinalis, fructus aurantii stir-fried with bran, stir-fried radish seed, poria cocos, rhizoma atractylodis macrocephalae, rhizoma pinellinae praeparata, pericarpium citri reticulatae, stiff silkworm, stir-fried malt, cassia twig, radix paeoniae alba, rhizoma cyperi with vinegar and honey-fried licorice root; the invention also discloses a preparation method and application of the traditional Chinese medicine composition. The prescription of the invention runs through the whole period of migraine, breaks the dilemma that migraine is easy to repeatedly attack and chronicize, lightens the intensity of headache, reduces the attack frequency, shortens the duration time, reduces the use of analgesic drugs for patients, reduces side effects, and can also improve the complications of patients such as digestive system problems, sleep disorders, mood swings and the like by integrally regulating the liver and spleen, thereby obviously improving the life quality of the patients.

Description

Traditional Chinese medicine composition for treating migraine as well as preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating migraine, and a preparation method and application thereof.

Background

Migraine is a disorder characterized by recurrent headache in one or both sides of the head, often accompanied by symptoms of autonomic nervous system dysfunction such as nausea and vomiting, photophobia, and voice intolerance. Migraine prevalence is on the rise in recent years, is good for the middle-aged, and has high disabling and disabling properties. The pathogenesis of migraine is not completely understood, and the classical theory at present comprises vascular theory, cortical spreading inhibition theory, trigeminal vascular theory, inflammatory mediator theory, central nervous system theory, genetic theory and the like, and the migraine aura is considered to be related to the cortical spreading inhibition theory at present, and the migraine is considered to be related to the activation of trigeminal vascular system. The release of pro-inflammatory factors results in a decrease in central pain threshold, which causes a disturbance in central regulation balance, and consequently, the trigeminal vascular system assumes a sensitized state, and thus, conditions such as aseptic neurogenic inflammation, degranulation of mast cells, and a diastolic change in meninges blood vessels occur, which causes an abnormal pain sensation. In recent years, studies have found that right-to-left shunts due to patent foramen ovale have a certain pathophysiological relationship with the occurrence of migraine with aura.

In western medicine, classical migraine treatment methods mainly comprise acute phase treatment and prophylactic treatment. The recommended therapeutic drugs for migraine in the acute attack stage are widely applied at present, such as non-steroidal anti-inflammatory drugs (such as aspirin), triptans (such as sumatriptan) and ergotamines (such as ergotamine tartrate), and preventive drugs for remission stage such as calcium channel blockers (such as flunarizine), beta receptor blockers (such as metoprolol), antiepileptics (such as valproic acid) and antidepressants (such as amitriptyline), but patients benefit slightly from the two classical treatment modes, and temporary pain relief of attack headache is equal to temporary bergamot, and the analgesic drugs are easy to develop into drug-dependent headache and various adverse reactions such as common digestive tract after long-term administration. With the continued intensive research into migraine biomarkers, new migraine drugs around the migraine biomarker targets are emerging, however, their high price and limited efficacy have made them prohibitive. Migraine belongs to the category of "headache" and "headache" in traditional Chinese medicine, and in 1994, "diagnosis of headache and evaluation criteria of curative effect" is divided into five types, namely liver-yang hyperactivity type, phlegm turbidity upward disturbance type, blood stasis and brain collateral obstruction type, deficiency of qi and blood type and liver-kidney yin deficiency type. Pain is the basic pathogenesis of pain due to obstruction and is caused by exogenous pathogenic factors and internal injury. Internal injury is caused by wind, fire, phlegm and blood stasis, and is mainly responsible for three zang-organs of liver, spleen and kidney, migraine symptoms in the attack stage are mainly characterized by blood stasis and internal stagnation and wind evil, and symptoms in the remission stage are mainly represented by liver qi stagnation, wherein liver yang hyperactivity is the main syndrome. Therefore, migraine is mostly treated by internal treatment methods such as liver, spleen and kidney theory, and a plurality of treatment methods such as activating blood circulation to remove stasis, calming liver wind, regulating qi to alleviate depression, tonifying liver and kidney are clinically adopted, and certain curative effects are shown.

For migraine sufferers, conventional clinical auxiliary examinations such as head CT and nuclear magnetic resonance often find positive results difficult. The inventors believe that regardless of the cause of the migraine, patients often experience anxiety and depressive symptoms as the condition progresses. Mood swings cause damage to the liver, cause stagnation of liver qi, and can not normally dredge and leak, further affect spleen and stomach functions, so that spleen and stomach weakness can not generate enough qi and blood essence to nourish the head. In addition, the cold nature or irregular eating habits of taking analgesics may further damage the spleen and stomach, resulting in phlegm-dampness ingrowth, impeding the normal function of the liver, and forming a pathological condition of stagnation of earth and wood. Whether the liver is affected by spleen and stomach or the spleen and stomach is affected by liver depression, the dysfunction of three organs of liver, spleen and stomach is finally caused, and the occurrence of single organ is rare. Therefore, the interactions of these three organs should be considered in combination during treatment. Furthermore, it is not neglected that migraine may cause complications, and patients often suffer from gastrointestinal discomfort such as nausea, vomiting, dyspepsia, diarrhea, constipation, and gastrointestinal diseases such as irritable bowel syndrome and inflammatory gastrointestinal diseases. According to the theoretical thinking of traditional Chinese medicine, these symptoms and diseases are all called migraine related spleen and stomach co-diseases, and may be accompanied by anxiety, depression, insomnia and other physical and psychological diseases, and can be explained by the core pathogenesis of liver spleen and stomach disharmony. Currently, a Chinese patent medicine aiming at the new mechanism of migraine is lacking, so that clinical requirements must be objectively evaluated to solve the treatment difficulty.

In view of this, the present inventors have conducted intensive studies in response to this need, and have made the present invention.

Disclosure of Invention

Through long-term temporary observation and continuous exploration, the invention takes 'liver qi stagnation, spleen and stomach weakness and liver and spleen stomach qi dysfunction' as the core pathogenesis of migraine, and provides a traditional Chinese medicine composition for treating migraine as well as a preparation method and application thereof aiming at the core pathogenesis, aiming at soothing liver and relieving depression, strengthening spleen and regulating spleen and stomach qi movement, and has an integral regulation effect on migraine without aura in each period of migraine (including the whole period of the period of onset of remission), nausea and vomiting, stomach and abdominal pain, dyspepsia, constipation, irritable bowel syndrome, chronic gastroenteritis and other common diseases of spleen and stomach, or complicating anxiety, depression, insomnia and other physical and psychological diseases, and can reduce or even stop the use of analgesic.

The technical scheme adopted by the invention is as follows:

The traditional Chinese medicine composition for treating migraine comprises, by mass, 5-20 parts of gastrodia elata, 5-20 parts of corydalis tuber, 5-20 parts of wormwood, 5-20 parts of codonopsis pilosula, 1-15 parts of fructus amomi, 1-15 parts of fennel, 5-20 parts of lindera root, 15-35 parts of vine of multiflower knotweed, 15-35 parts of cortex albiziae, 5-25 parts of red sage root, 5-20 parts of magnolia officinalis, 5-20 parts of bitter orange fried with bran, 10-25 parts of radish seed, 5-25 parts of poria cocos, 10-25 parts of bighead atractylodes rhizome, 1-15 parts of rhizoma pinellinae praeparata, 1-15 parts of pericarpium citri reticulatae, 1-15 parts of stiff silkworm, 10-25 parts of roasted malt, 1-15 parts of cassia twig, 5-25 parts of white paeony root, 5-20 parts of vinegar-processed nutgrass galingale rhizome and 1-15 parts of roasted liquorice.

The traditional Chinese medicine composition comprises, by mass, 7-18 parts of gastrodia elata, 7-18 parts of rhizoma corydalis, 7-18 parts of wormwood, 7-18 parts of codonopsis pilosula, 3-13 parts of fructus amomi, 3-13 parts of fennel, 7-18 parts of radix linderae, 17-33 parts of caulis polygoni multiflori, 17-33 parts of cortex albiziae, 7-23 parts of radix salviae miltiorrhizae, 7-18 parts of cortex magnoliae officinalis, 7-18 parts of bran-fried fructus aurantii, 12-23 parts of fried radish seeds, 7-23 parts of poria cocos, 12-23 parts of bighead atractylodes rhizome, 3-13 parts of rhizoma pinellinae praeparata, 3-13 parts of pericarpium citri reticulatae, 3-13 parts of stiff silkworm, 12-23 parts of fried malt, 3-13 parts of cassia twig, 7-23 parts of radix paeoniae alba, 7-18 parts of rhizoma cyperi with vinegar and 3-13 parts of roasted liquorice.

The traditional Chinese medicine composition comprises, by mass, 10-15 parts of gastrodia elata, 10-15 parts of corydalis tuber, 10-15 parts of wormwood, 10-15 parts of codonopsis pilosula, 5-10 parts of fructus amomi, 5-10 parts of fennel, 10-15 parts of lindera root, 20-30 parts of tuber fleeceflower stem, 20-30 parts of cortex albiziae, 10-20 parts of red sage root, 10-15 parts of officinal magnolia bark, 10-15 parts of bran-fried bitter orange, 15-20 parts of fried radish seed, 10-20 parts of poria cocos, 15-20 parts of bighead atractylodes rhizome, 5-10 parts of rhizoma pinellinae praeparata, 5-10 parts of pericarpium citri reticulatae, 5-10 parts of stiff silkworm, 15-20 parts of fried malt, 5-10 parts of cassia twig, 10-20 parts of white peony root, 10-15 parts of vinegar-processed nutgrass galingale rhizome and 5-10 parts of roasted liquorice.

The invention also provides application of the traditional Chinese medicine composition for treating migraine in preparation of a medicine for treating migraine, in particular application in preparation of a medicine for treating migraine without aura.

The invention also provides a medicine for treating migraine, which comprises the traditional Chinese medicine composition for treating migraine and pharmaceutically acceptable auxiliary materials.

Preferably, the medicament is in the form of Chinese medicinal decoction, granule, pill, paste, capsule, tablet, tea, suspension, powder or oral liquid.

The invention also provides a preparation method of the medicine for treating migraine, wherein the medicine is a traditional Chinese medicine decoction, and the preparation method is as follows:

Weighing the raw materials according to the weight portion, cleaning, drying, cutting, crushing, sieving and uniformly mixing;

Adding clear water which is 6-8 times the volume of the raw material medicine obtained in the first step, soaking for 30-50 minutes, boiling with strong fire, continuously decocting with slow fire for 30-45 minutes, filtering with a traditional Chinese medicine sieve to obtain a first filtrate, adding water into residues without the residues, boiling with strong fire, continuously decocting with slow fire for 30-45 minutes, filtering with a traditional Chinese medicine sieve to obtain a second filtrate, and combining the first filtrate and the second filtrate to obtain the traditional Chinese medicine decoction.

The invention also provides a preparation method of the medicine for treating migraine, wherein the medicine is paste, and the preparation method is as follows:

Weighing the raw materials according to the weight portion, cleaning, drying, cutting, crushing, sieving and uniformly mixing;

Adding clear water which is 6-8 times the volume of the raw material medicine obtained in the first step, soaking for 30-50 minutes, boiling with strong fire, continuously decocting with slow fire for 30-45 minutes, filtering with a traditional Chinese medicine sieve to obtain a first filtrate, adding water into the residues without the residues, boiling with strong fire, continuously decocting with slow fire for 30-45 minutes, filtering with a traditional Chinese medicine sieve to obtain a second filtrate, and combining the first filtrate and the second filtrate;

And thirdly, decocting the combined filtrate obtained in the second step with small fire at 100-120 ℃, continuously stirring, and pouring the paste into a dry vessel when the medicine is hung on the flag to obtain the paste.

The technical scheme of the invention has the following beneficial effects:

The traditional Chinese medicine composition takes rhizoma gastrodiae, rhizoma corydalis and rhizoma cyperi as principal drugs, and has the effects of calming endogenous wind and calming liver, dispelling wind and activating meridians to stop pain, soothing liver and promoting qi circulation, activating blood and stopping pain, and the rhizoma cyperi has the effects of promoting qi circulation and relieving depression, regulating menstruation and stopping pain, and the three drugs are used for regulating qi and activating blood, soothing liver and stopping wind, and promoting qi circulation and stopping pain; the codonopsis pilosula is used for strengthening spleen and tonifying middle energizer, promoting transportation and transformation of middle energizer, strengthening spleen and moisturizing, so that spleen and stomach pivot machine is smooth, fennel, radix linderae and fructus amomi are used for warming middle energizer and relieving pain, promoting qi and harmonizing stomach, cortex albiziae and caulis polygoni multiflori are used for nourishing blood and softening liver, soothing liver and harmonizing qi and blood, are used as ministerial drugs, are used for assisting in strengthening spleen and supplementing qi, are also used for strengthening spleen and tonifying qi by adding bighead atractylodes rhizome and poria cocos, are used for strengthening the effect of spleen and moisturizing turbidity by using wormwood, dried orange peel and rhizoma pinelliae by further processing the second-harmonic component Shang Sao, fructus aurantii and mangnolia officinalis are used for descending qi and dredging viscera, malt and radish seed are used for soothing liver and descending stomach, cassia twig and radix paeoniae alba are used for harmonizing nutrient and spleen and stomach, and stomach are used for qi and blood nutrient and qi and blood, and biochemical source, and stiff silkworm is used for calming wind and relieving spasm, dispelling wind and relieving pain, resolving phlegm and resolving hard-related aspects of qi and treating headache. The medicines are matched to smooth liver qi, spleen qi is healthy and transported, stomach qi is smooth, damp turbidity is removed, and headache is stopped when qi movement is smooth.

The invention provides a Chinese medicinal composition for treating migraine and nuclear heart disease, which aims at solving the problems that migraine is easy to repeatedly attack and chronic, and the treatment mode of acute attack and remission stages is not retained by taking weakness of spleen and stomach, deficiency of qi and blood as the principal, and disharmony of qi and qi of liver, spleen and stomach as the principal, and through the whole period of migraine, the Chinese medicinal composition provided by the invention dynamically and integrally treats the migraine through the whole regulation of liver and spleen and stomach, and is not limited by distinction between attack stage and remission stage. In addition, the invention can lighten the intensity of the headache, reduce the frequency of the attack, shorten the duration, reduce the use of the analgesic by patients, reduce the side effect of the analgesic and effectively interrupt the vicious circle of the headache during the attack period of the migraine. In this way, the method can also improve various complications of the patient, such as spleen and stomach related co-diseases, sleep disorder, mood fluctuation and other physical and psychological diseases, so as to obviously improve the life quality of the patient.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. Thus, the following detailed description of the embodiments provided herein is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, based on the embodiments of the invention, which are apparent to those of ordinary skill in the art without inventive faculty, are intended to be within the scope of the invention.

The embodiment finds that the traditional Chinese medicine and the Chinese patent medicine which are commonly used in clinic and take the methods of activating blood circulation to dissipate blood stasis, dispelling wind and calming the liver as the main effects have limited treatment effects on migraine, and clinically observes that the migraine is often accompanied by symptoms of anorexia, diarrhea, acid regurgitation, eructation, even discomfort of the spleen and stomach and the like, or gastrointestinal diseases such as chronic gastritis, chronic enteritis and the like, and the symptoms of the stomach and the intestine are caused by night stay, alcoholism and the like before, after migraine occurs, or the migraine occurs before and after the symptoms of the stomach and the intestine are accompanied by the symptoms of the stomach and the intestine. Aiming at complex symptoms, the applicant proposes that the migraine nuclear heart disease machine takes weakness of spleen and stomach and deficiency of qi and blood as the principal, and disorder of qi and qi of liver, spleen and stomach as the principal. The temporary syndrome takes ' resolving depression and regulating middle warmer and regulating liver, spleen and stomach qi as a treatment method, and follows the principle of ' treating spleen without stomach, treating stomach and spleen, treating spleen and stomach must be connected with liver ', and adopts liver, spleen and stomach three-in-one synchronous treatment. The recipe is also called "depression-relieving and middle-jiao-regulating method" because of the liver soothing and liver-soothing, the depression-relieving, spleen-strengthening, stomach-regulating, the clear-ascending, turbid-descending, and the middle-jiao-regulating method, so that migraine is treated according to the different pathogenesis of the liver, spleen and stomach in clinic, the modified recipe is modified with some emphasis, the circular method is activated, and the clinical curative effect is remarkable.

The invention provides a traditional Chinese medicine composition for treating migraine, which comprises, by mass, 5-20 parts of gastrodia elata, 5-20 parts of corydalis tuber, 5-20 parts of wormwood, 5-20 parts of codonopsis pilosula, 1-15 parts of fructus amomi, 1-15 parts of fennel, 5-20 parts of lindera root, 15-35 parts of tuber fleeceflower stem, 15-35 parts of cortex albiziae, 5-25 parts of radix salviae miltiorrhizae, 5-20 parts of mangnolia officinalis, 5-20 parts of bitter orange fried with bran, 10-25 parts of radish seed, 5-25 parts of poria cocos, 10-25 parts of bighead atractylodes rhizome, 1-15 parts of rhizoma pinellinae praeparata, 1-15 parts of pericarpium citri reticulatae, 1-15 parts of stiff silkworm, 10-25 parts of roasted malt, 1-15 parts of cassia twig, 5-25 parts of white paeony root, 5-20 parts of vinegar-processed nutgrass galingale rhizome and 1-15 parts of honey-fried licorice root.

The preparation method comprises the following medicinal materials, by mass, 7-18 parts of gastrodia elata, 7-18 parts of corydalis tuber, 7-18 parts of wormwood, 7-18 parts of codonopsis pilosula, 3-13 parts of fructus amomi, 3-13 parts of fennel, 7-18 parts of lindera root, 17-33 parts of caulis polygoni multiflori, 17-33 parts of cortex albiziae, 7-23 parts of red sage root, 7-18 parts of officinal magnolia bark, 7-18 parts of bitter orange, 12-23 parts of fried radish seed, 7-23 parts of poria cocos, 12-23 parts of bighead atractylodes rhizome, 3-13 parts of rhizoma pinellinae praeparata, 3-13 parts of pericarpium citri reticulatae, 3-13 parts of stiff silkworm, 12-23 parts of fried malt, 3-13 parts of cassia twig, 7-23 parts of white peony root, 7-18 parts of vinegar-processed nutgrass galingale rhizome, and 3-13 parts of honey-fried licorice root.

The preparation method comprises the following medicinal materials, by mass, 10-15 parts of gastrodia elata, 10-15 parts of corydalis tuber, 10-15 parts of wormwood, 10-15 parts of codonopsis pilosula, 5-10 parts of fructus amomi, 5-10 parts of fennel, 10-15 parts of lindera root, 20-30 parts of tuber fleeceflower stem, 20-30 parts of cortex albiziae, 10-20 parts of red sage root, 10-15 parts of officinal magnolia bark, 10-15 parts of bitter orange fried with bran, 15-20 parts of radish seed, 10-20 parts of poria cocos, 15-20 parts of bighead atractylodes rhizome, 5-10 parts of rhizoma pinellinae praeparata, 5-10 parts of pericarpium citri reticulatae, 5-10 parts of stiff silkworm, 15-20 parts of fried malt, 5-10 parts of cassia twig, 10-20 parts of white peony root, 10-15 parts of vinegar-processed nutgrass galingale rhizome and 5-10 parts of honey-fried licorice root.

The invention also provides application of the traditional Chinese medicine composition for treating migraine in preparation of a medicine for treating migraine, in particular application in preparation of a medicine for treating migraine without aura.

The invention also provides a medicine for treating migraine, which comprises the traditional Chinese medicine composition for treating migraine and pharmaceutically acceptable auxiliary materials.

As a preferred embodiment, the medicament is in the form of a traditional Chinese medicine decoction, granules, pills, paste, capsules, tablets, tea, suspension, powder or oral liquid.

The invention also provides a preparation method of the medicine for treating migraine, wherein the medicine is a traditional Chinese medicine decoction, and the preparation method is as follows:

Weighing the raw materials according to the weight portion, cleaning, drying, cutting, crushing, sieving and uniformly mixing;

Adding clear water which is 6-8 times the volume of the raw material medicine obtained in the first step, soaking for 30-50 minutes, boiling with strong fire, and continuously decocting with slow fire for 30-45 minutes;

Filtering with a traditional Chinese medicine sieve to obtain a first filtrate, adding water into the residues without passing through the residues, boiling with strong fire, continuously decocting with slow fire for 30-45 min, filtering the residues with a traditional Chinese medicine sieve to obtain a second filtrate, and combining the first filtrate and the second filtrate to obtain the traditional Chinese medicine decoction.

The invention is described in further detail below in connection with specific examples:

Example 1

The traditional Chinese medicine composition for treating migraine is prepared from the following traditional Chinese medicine formula raw materials of 5 parts of gastrodia elata, 5 parts of corydalis tuber, 5 parts of wormwood, 5 parts of codonopsis pilosula, 1 part of fructus amomi, 1 part of fennel, 5 parts of radix linderae, 15 parts of vine of multiflower knotweed, 15 parts of cortex albiziae, 5 parts of red sage root, 5 parts of officinal magnolia bark, 5 parts of bitter orange stir-fried with bran, 10 parts of radish seed, 5 parts of poria cocos, 10 parts of bighead atractylodes rhizome, 1 part of rhizoma pinellinae praeparata, 1 part of pericarpium citri reticulatae, 1 part of stiff silkworm, 10 parts of malt stir-fried, 1 part of cassia twig, 5 parts of white paeony root, 5 parts of rhizoma cyperi and 1 part of honey-fried licorice root. The preparation method of the medicine for treating migraine in the embodiment 1 comprises the following steps:

Weighing the raw materials according to the weight portion, cleaning, drying, cutting, crushing, sieving and uniformly mixing;

adding clear water which is 7 times the volume of the raw material medicine obtained in the first step, soaking for 40 minutes, boiling with strong fire, and continuously decocting with slow fire for 40 minutes;

Filtering with a Chinese medicinal sieve to obtain a first filtrate, adding water into the residue, boiling with strong fire, decocting with slow fire for 40 min, filtering with a Chinese medicinal sieve to obtain a second filtrate, and mixing the first filtrate and the second filtrate to obtain Chinese medicinal decoction.

Example 2

The traditional Chinese medicine composition for treating migraine is prepared from the following raw materials of 7 parts of gastrodia elata, 7 parts of rhizoma corydalis, 7 parts of wormwood, 7 parts of codonopsis pilosula, 3 parts of fructus amomi, 3 parts of fennel, 7 parts of radix linderae, 17 parts of caulis polygoni multiflori, 17 parts of cortex albiziae, 7 parts of radix salviae miltiorrhizae, 7 parts of cortex magnoliae officinalis, 7 parts of fructus aurantii stir-fried with bran, 12 parts of radish seed, 7 parts of poria cocos, 12 parts of bighead atractylodes rhizome, 3 parts of rhizoma pinellinae praeparata, 3 parts of pericarpium citri reticulatae, 3 parts of stiff silkworm, 12 parts of malt stir-fried, 3 parts of cassia twig, 7 parts of white paeony root, 7 parts of rhizoma cyperi and 3 parts of honey-fried licorice root. The preparation method of the medicine for treating migraine in the embodiment 2 is the same as that in the embodiment 1.

Example 3

The traditional Chinese medicine composition for treating migraine is prepared from the following traditional Chinese medicine formula raw materials of 10 parts of gastrodia elata, 10 parts of corydalis tuber, 10 parts of wormwood, 10 parts of codonopsis pilosula, 5 parts of fructus amomi, 5 parts of fennel, 10 parts of radix linderae, 20 parts of vine of multiflower knotweed, 20 parts of cortex albiziae, 10 parts of red sage root, 10 parts of officinal magnolia bark, 10 parts of bitter orange stir-fried with bran, 15 parts of radish seed, 10 parts of poria cocos, 15 parts of bighead atractylodes rhizome, 5 parts of rhizoma pinellinae praeparata, 5 parts of pericarpium citri reticulatae, 5 parts of stiff silkworm, 15 parts of malt stir-fried, 5 parts of cassia twig, 10 parts of white paeony root, 10 parts of rhizoma cyperi and 5 parts of honey-fried licorice root. The preparation method of the medicine for treating migraine in the embodiment 3 is the same as that in the embodiment 1.

Example 4

The traditional Chinese medicine composition for treating migraine is prepared from the following traditional Chinese medicine formula raw materials of 15 parts of gastrodia elata, 15 parts of corydalis tuber, 15 parts of wormwood, 15 parts of codonopsis pilosula, 10 parts of fructus amomi, 10 parts of fennel, 15 parts of radix linderae, 30 parts of caulis polygoni multiflori, 30 parts of cortex albiziae, 20 parts of radix salviae miltiorrhizae, 15 parts of cortex magnoliae officinalis, 15 parts of bitter orange fried with bran, 20 parts of radish seed, 20 parts of poria cocos, 20 parts of bighead atractylodes rhizome, 10 parts of rhizoma pinellinae praeparata, 10 parts of pericarpium citri reticulatae, 10 parts of stiff silkworm, 20 parts of malt fried, 10 parts of cassia twig, 20 parts of white paeony root, 15 parts of rhizoma cyperi with vinegar and 10 parts of honey-fried licorice root. The preparation method of the medicine for treating migraine in the embodiment 4 comprises the following steps:

Weighing the raw materials according to the weight portion, cleaning, drying, cutting, crushing, sieving and uniformly mixing;

Adding 7 times of clear water into the bulk drug obtained in the first step, soaking for 40 minutes, boiling with strong fire, continuously decocting with slow fire for 40 minutes, filtering with a traditional Chinese medicine sieve to obtain a first filtrate, adding water into the residues, boiling with strong fire, continuously decocting with slow fire for 40 minutes, filtering with a traditional Chinese medicine sieve to obtain a second filtrate, and combining the first filtrate and the second filtrate;

And thirdly, decocting the combined filtrate in the second step with small fire at 120 ℃, continuously stirring, and pouring the paste into a dry vessel when the medicine is hung on the flag, thus obtaining the paste.

Example 5

The traditional Chinese medicine composition for treating migraine is prepared from the following traditional Chinese medicine formula raw materials of 18 parts of gastrodia elata, 18 parts of rhizoma corydalis, 18 parts of wormwood, 18 parts of codonopsis pilosula, 13 parts of fructus amomi, 13 parts of fennel, 18 parts of radix linderae, 33 parts of caulis polygoni multiflori, 33 parts of cortex albiziae, 23 parts of radix salviae miltiorrhizae, 18 parts of cortex magnoliae officinalis, 18 parts of fructus aurantii stir-fried with bran, 23 parts of semen raphani stir-fried, 23 parts of poria cocos, 23 parts of bighead atractylodes rhizome, 13 parts of rhizoma pinellinae praeparata, 13 parts of pericarpium citri reticulatae, 13 parts of stiff silkworm, 23 parts of stir-fried malt, 13 parts of cassia twig, 23 parts of radix paeoniae alba, 18 parts of rhizoma cyperi and 13 parts of roasted liquorice. The preparation method of the medicine for treating migraine in example 5 is the same as in example 4.

Example 6

The traditional Chinese medicine composition for treating migraine is prepared from 20 parts of gastrodia elata, 20 parts of rhizoma corydalis, 20 parts of wormwood, 20 parts of codonopsis pilosula, 15 parts of fructus amomi, 15 parts of fennel, 20 parts of radix linderae, 35 parts of caulis polygoni multiflori, 35 parts of cortex albiziae, 25 parts of radix salviae miltiorrhizae, 20 parts of cortex magnoliae officinalis, 20 parts of bitter orange stir-fried with bran, 25 parts of radish seed, 25 parts of poria cocos, 25 parts of bighead atractylodes rhizome, 15 parts of rhizoma pinellinae praeparata, 15 parts of pericarpium citri reticulatae, 15 parts of stiff silkworm, 25 parts of malt stir-fried, 15 parts of cassia twig, 25 parts of white paeony root, 20 parts of rhizoma cyperi and 15 parts of honey-fried licorice root. The preparation method of the medicine for treating migraine in example 6 is the same as that in example 4.

The traditional Chinese medicine composition for treating migraine is summarized through decades of clinical experience, and is provided with a database of treating migraine by virtue of theory Hua Rong, wherein the traditional Chinese medicine composition for treating migraine by virtue of the traditional Chinese medicine composition comprises poria cocos, bighead atractylodes rhizome, codonopsis pilosula, rhizoma pinellinae praeparata, pericarpium citri reticulatae, honey-fried licorice root, rhizoma cyperi, fructus amomi, roasted malt, roasted radish seed, cortex magnoliae officinalis, bitter orange fried with bran, fennel, radix linderae, rhizoma corydalis, wormwood, cassia twig, radix paeoniae alba, caulis polygoni multiflori, cortex albiziae and the like, and is added with ministerial medicine radix salviae miltiorrhizae on the basis of combining the traditional Chinese medicine composition for treating migraine by virtue of the traditional Chinese medicine composition by virtue of the theory Hua Rong, has the effects of activating blood circulation, removing stasis, regulating menstruation, relieving pain, relieving restlessness and soothing nerves, and promoting blood circulation, dredging collaterals, relieving spasm by virtue of stiff silkworm, dispelling wind, relieving pain, resolving phlegm, dispersing mass, expelling wind, and being good at running the head, face, eliminating phlegm, treating intractable headache, and calming by virtue of wind, and calming the liver. The three medicines are applied on the basis of soothing liver, strengthening spleen and regulating stomach of the original prescription, and aim at the characteristics of excessive symptoms such as wind, phlegm and blood stasis during headache, so as to achieve the aim of treating both principal and secondary aspect of disease, and have the effects of relieving urgency and pain, reducing headache attack degree and reducing headache frequency. Specific clinical trial data are as follows:

Experimental identification of the dose versus potency conditions used in the present invention using the drugs prepared in preferred example 3:

1. Case sources

Patients hospitalized in me hospital for migraine headaches from 2022 to 2023 and met selection criteria and diagnostic criteria.

2. Selection criteria

(1) Meets the Western diagnosis standard of migraine;

(2) Meets the traditional Chinese medicine diagnosis standard of the head wind disease;

(3) The basic diagnosis and treatment information of the patient is complete and the first diagnosis is treated by the traditional Chinese medicine decoction;

(4) Excluding other types of migraine cases, such as tension headache, cluster headache, and secondary migraine cases, patients who are reluctant to receive traditional Chinese medicine treatment will not be included in the study.

3. Diagnostic criteria

3.1 Western medicine standard according to migraine classification and diagnosis criteria in the third edition of International headache disorder Classification issued by the Classification Commission of headache Council of 2018.

(1) Headache attacks last for 4-72 hours (untreated or not treated).

(2) Headache has at least 2 of the following 4 characteristics of ① out-of-lateral distribution, ② pulsatility, ③ pain degree of moderate or severe, ④ daily physical activity aggravates headache or avoids daily activities (such as walking or going up stairs, etc.) due to headache.

(3) At least 1 of the following symptoms, ① nausea and/or vomiting, ② photophobia and/or phonophobia, are present at the onset of headache.

At least 5 headache attacks satisfying both items (1) (2) (3) are not better explained by another diagnosis of ICHD-3 headache disorder.

3.2 Traditional Chinese medicine standard refers to traditional Chinese medicine diagnosis of "head wind" issued by the national traditional Chinese medicine administration of 2016.

4. Treatment regimen

60 Patients with migraine at home are randomly selected, the traditional Chinese medicine decoction prepared by using the preferred embodiment 3 of the invention is 250mL for one dose a day, 1 treatment course is 7 days, and 4 treatment courses are taken for statistics of curative effect, and patients are ordered to regulate emotion, pay attention to rest and take light diet.

5. Standard of efficacy

The clinical curative effect is formulated by referring to the guidelines of clinical research on new Chinese medicine. The headache symptoms completely disappear, for example, the symptoms of the headache are marked as clinical cure when the disease course record of ' no attack ' appears, the headache degree, duration, times and accompanying symptoms are obviously improved, each attack basically does not affect normal life and work, for example, the headache degree, duration, times and accompanying symptoms are improved when the disease course record of ' obvious alleviation ', ' obvious improvement ', ' disabling pain ' appears, the headache degree, duration, times and accompanying symptoms slightly affect normal work, for example, the headache degree, duration, time and accompanying symptoms are marked as effective when the disease course record of ' alleviation ', ' improvement ', ' disabling pain ' appears, the headache degree, duration, times and accompanying symptoms are not improved or aggravated, the headache degree, the headache still remain, the headache is still accompanied with vomiting ' when the attack is not effective.

6. Data analysis

The traditional Chinese medicine composition prepared in the embodiment 3 of the invention is used for treating patients and 60 patients with obvious effects using the original published formula of resolving depression and Chinese general prescription in the database of treating migraine of Hua Rong theory are compared with relevant indexes of curative effects.

6.1 Total effective treatment

TABLE 1 Total effective treatment rate

The results shown in Table 1 show that the total effective rate of the traditional Chinese medicine composition is higher than that of the traditional Chinese medicine composition for relieving depression and treating the middle-aged, and the traditional Chinese medicine composition for relieving depression and treating the middle-aged is high in clinical cure rate Yu Jieyu and the traditional Chinese medicine composition for treating the middle-aged is visited after 4 treatment courses, and the traditional Chinese medicine composition is superior to the traditional Chinese medicine composition for relieving depression and treating the middle-aged after improvement and innovation of the formula.

6.2 Headache attacks are improved to a degree

TABLE 2 improvement of VAS before and after treatment

As shown in Table 2, the visual simulation scoring method (VAS scoring method) is used as a standard, and the comparison is carried out before and after the treatment of two groups of patients, wherein the reduction degree of the VAS score is high Yu Jieyu, and the Zhongtong prescription group shows that the invention can play a more remarkable role in relieving headache degree compared with the prior art before improvement, and plays a role in treating the symptoms of the headache in the headache attack stage by adding the blood-activating and wind-dispelling medicaments.

6.3 Analgesic conditions

TABLE 3 improved use of analgesic after treatment

As shown in Table 3, after the patients treated with the Chinese medicinal composition of the present invention were treated, 15 patients had stopped taking the analgesic, and 35 patients had reduced the amount of the analgesic, and the patients who stopped or reduced the amount of the analgesic accounted for 90.91% of the patients who took the analgesic. The treatment group analgesic drug of the invention is stopped or the decrement ratio is high Yu Jieyu and the Zhongtong prescription group, which shows that the traditional Chinese medicine composition can more obviously improve and reduce the use of the analgesic drug, can avoid the new migraine patients from falling into the malignant circulation of the analgesic drug dependence, can lead the patients with refractory excessive migraine to get rid of the excessive medicine gradually, and take away the drug dependence, thereby playing the role of long-term treatment.

6.4 Days for taking medicine for obvious effect

TABLE 4 average days of drug administration to apparent effect

As shown in Table 4, compared with the original depression relieving and Zhongtong prescription, the time for treating headache is shorter than that of the original depression relieving and Zhongtong prescription, which shows that the traditional Chinese medicine composition can improve headache symptoms in a shorter time after adding related medicines, relieve the attack degree of headache, play a role in treatment faster, relieve pain of patients, increase the trust degree of the patients on treatment and ensure that the patients can finish the medicine treatment.

The traditional Chinese medicine composition is modified on the basis of long-term clinical researches of the applicant and the understanding of the pathogenesis of migraine 'liver-spleen stomach disharmony', has the effects of soothing liver and relieving depression, strengthening spleen and relieving pain by adding 3 medicines of gastrodia elata, stiff silkworm and radix salviae miltiorrhizae, and has the effects of promoting blood circulation and removing obstruction in collaterals, dispelling wind and relieving pain by comparing the curative effect data before and after addition, thereby strengthening the overall regulation of liver and spleen, relieving headache, and remarkably relieving headache degree, and further achieving the effects of reducing the use of analgesic medicines and avoiding excessive headache caused by medicines. The composition can also improve various complications of patients, such as migraine-related spleen and stomach co-diseases, sleep disorder, mood swings and other physical and psychological diseases, thereby remarkably improving the life quality of the patients. The invention has definite curative effect, does not contain toxic medicines specified in pharmacopoeia, is safe to use, is a great innovation in migraine treatment, and has strong clinical value.

Typical cases:

Case 1: li Mou, female, 30 years old, 2024, 9 first diagnosis, paroxysmal right temporal and orbital pain 5 years, aggravated for 1 year. The patients begin to regularly suffer from migraine before 5 years, the operation of the external hospital foramen ovale occlusion is carried out in 11 months in 2023, the operation is slightly released, but the pain is still relieved after the operation, the patients still suffer from 2 times of attack per month, each time lasting for 48 hours, VAS is 6 minutes, and the effect of taking ibuprofen to relieve pain is poor. The traditional Chinese medicine decoction provided by the embodiment 3 is taken for 1 dose per day, decocted twice, decocted to 250-300 ml each time, and taken warm after meals for 21 days. The headache degree is obviously reduced after taking the medicine for one week, the attack frequency is reduced in VAS of 3 minutes, the headache is not needed for 1 week at the time of three diagnosis, the pain relieving medicine is stopped taking, and the stool is smooth. The traditional Chinese medicine ointment prepared in the embodiment 4 of the invention is taken once in the morning and at night, 10g each time is taken for 28 days as 1 course of treatment, and no obvious headache is caused after the traditional Chinese medicine ointment is taken for 1 course of treatment. The result shows that the prescription can effectively relieve the symptoms of migraine patients such as repeated headache, constipation and the like, can reduce the frequency of headache attacks, reduces the use of analgesic drugs, and has obvious curative effect on migraine patients with liver and spleen imbalance.

Case 2, wang Mou, women, 38 years old, first diagnosis 10 months in 2024, 4 years before and after menstrual period. Patients begin to suffer from headache on the two temporal sides after 4 years before and after delivery, nausea and vomiting, and pain relieving drugs are needed to be taken every time the patients take the symptoms before and after menstrual period, sleep is poor, menstrual volume is less, complexion is sallow, tongue is light and dark, and tongue coating is thin and white. The Western medicine is diagnosed with migraine, the Chinese medicine is diagnosed with menstrual headache (liver and spleen stomach disharmony), and the traditional Chinese medicine decoction of the embodiment 3 is taken 1 dose per day, decocted twice, decocted to 250-300 ml each time, taken warm after meals and treated for 21 days. Headache is not caused during the period of taking the medicine again in the second diagnosis, the analgesic medicine can be stopped taking, the medicine is taken for 21 days again, the sleep is improved, and no headache is caused before and after the menstrual period. The invention can effectively relieve the headache of the migraine patients related to menstruation, can cure the headache without recrudescence after taking the medicine for one month, can stop the analgesic, can improve the accompanying symptoms of insomnia and the like of the patients, and has obvious curative effect on the migraine patients with liver-spleen-stomach disharmony.

Case 3, liu Mou, female, 58 years, 2024, 7 months first diagnosis, repeated 20 years of right temporal pain, aggravated for 2 years. VAS is 8 in the onset, nausea and vomiting are accompanied, the onset of one month is 4-5 times, the period lasts for 48-72 hours, the effect is poor, the mother and the sister have the migraine medical history, plain constipation, eructation and acid regurgitation, poor appetite, pale tongue and white greasy tongue coating, migraine, chronic headache and excessive-use headache are diagnosed by Western medicine, headache (liver-spleen stomach disharmony syndrome) is diagnosed by Western medicine, the traditional Chinese medicine decoction of the embodiment 3 is taken, 1 dose per day is decocted twice, each time is decocted to 250-300 ml by water, and the decoction is taken after meals for 21 days. The frequency of the headache is reduced, the attack time is shortened by 1 time per month, the degree is reduced, VAS is 5 minutes, nausea and vomiting are avoided, and the analgesic can be stopped. The whole spirit of the patient is good, and the stool is smooth. After the treatment is continued for 21 days, the headache frequency is obviously reduced, the degree is slight, the traditional Chinese medicine ointment prepared in the embodiment 4 of the invention is continuously taken once in the morning and at night, 10g each time is taken for 28 days, 1 treatment course is taken, 2 treatment courses are taken, no obvious headache is caused, and the traditional Chinese medicine ointment is basically healed. The invention can effectively relieve the headache symptoms of patients suffering from chronic and drug-dependent migraine and familial hereditary tendency, lighten the pain degree during attack, reduce the attack frequency, gradually reduce the use of analgesic drugs, finally get rid of the analgesic drugs, lighten the accompanying symptoms, improve the related co-diseases of the spleen and the stomach, integrally regulate the migraine syndrome symptoms of the patients, and has obvious long-term curative effect on the patients suffering from the intractable migraine caused by the imbalance of the liver and the spleen and the stomach.

Case 4: rong Mou, women, 39 years old, 2024, 9 months first visit, 20 years before and after repeated menstrual period, aggravated for 3 months, and mother also had a history of headache for more than one year. Patients begin to develop premenstrual and postmenstrual onset anterior and posttemporal headaches over 20 years, with nausea and vomiting, exacerbation of pain in the 3 months, and begin to take analgesics. Large menstrual flow, more blood clots, poor sleep, tension and anxiety, pale tongue with fat teeth marks and cracks and white and greasy tongue coating; the Western medicine is diagnosed with migraine, the Chinese medicine is diagnosed with menstrual headache (liver and spleen stomach disharmony), and the traditional Chinese medicine decoction of the embodiment 3 is taken 1 dose per day, decocted twice, decocted to 250-300 ml each time, taken after meals for 28 days. The headache is reduced, sleep is improved, and emotion is relaxed. After the treatment is continued for 14 days, the headache frequency is obviously reduced, the headache is not caused by the first month, the mental state is obviously improved, the menstrual blood clot is reduced, the traditional Chinese medicine ointment prepared in the embodiment 4 of the invention is continuously taken once in the morning and at night, 10g each time is taken for 1 treatment course for 28 days, the headache is occasionally caused to be mild after taking for 1 treatment course, and the life is not affected. The present invention has the functions of improving symptoms, migraine complications, tension anxiety, etc. and has obvious long-term curative effect on migraine.

The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, and various modifications and variations may be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (8)

1. The traditional Chinese medicine composition for treating migraine is characterized by comprising, by mass, 5-20 parts of gastrodia elata, 5-20 parts of rhizoma corydalis, 5-20 parts of wormwood, 5-20 parts of codonopsis pilosula, 1-15 parts of fructus amomi, 1-15 parts of fennel, 5-20 parts of lindera root, 15-35 parts of caulis polygoni multiflori, 15-35 parts of cortex albiziae, 5-25 parts of radix salviae miltiorrhizae, 5-20 parts of mangnolia officinalis, 5-20 parts of bitter orange stir-fried with bran, 10-25 parts of radish seed, 5-25 parts of poria cocos, 10-25 parts of bighead atractylodes rhizome, 1-15 parts of rhizoma pinellinae praeparata, 1-15 parts of pericarpium citri reticulatae, 1-15 parts of stiff silkworm, 10-25 parts of roasted malt, 1-15 parts of cassia twig, 5-25 parts of white paeony root, 5-20 parts of vinegar-20 parts of nutgrass galingale rhizome and 1-15 parts of honey-fried licorice root.

2. The traditional Chinese medicine composition for treating migraine according to claim 1, which is characterized by comprising, by mass, 7-18 parts of gastrodia elata, 7-18 parts of rhizoma corydalis, 7-18 parts of wormwood, 7-18 parts of codonopsis pilosula, 3-13 parts of fructus amomi, 3-13 parts of fennel, 7-18 parts of lindera root, 17-33 parts of caulis polygoni multiflori, 17-33 parts of cortex albiziae, 7-23 parts of radix salviae miltiorrhizae, 7-18 parts of magnolia officinalis, 7-18 parts of bitter orange stir-fried with bran, 12-23 parts of fried radish seed, 7-23 parts of poria cocos, 12-23 parts of bighead atractylodes rhizome, 3-13 parts of rhizoma pinellinae praeparata, 3-13 parts of pericarpium citri reticulatae, 3-13 parts of stiff silkworm, 12-23 parts of fried malt, 3-13 parts of cassia twig, 7-23 parts of white paeony root, 7-18 parts of vinegar-fried nutgrass galingale rhizome and 3-13 parts of honey-fried licorice root.

3. The traditional Chinese medicine composition for treating migraine according to claim 1, which is characterized by comprising, by mass, 10-15 parts of gastrodia elata, 10-15 parts of rhizoma corydalis, 10-15 parts of wormwood, 10-15 parts of codonopsis pilosula, 5-10 parts of fructus amomi, 5-10 parts of fennel, 10-15 parts of lindera root, 20-30 parts of caulis polygoni multiflori, 20-30 parts of cortex albiziae, 10-20 parts of radix salviae miltiorrhizae, 10-15 parts of magnolia officinalis, 10-15 parts of bitter orange fried with bran, 15-20 parts of fried radish seed, 10-20 parts of poria cocos, 15-20 parts of bighead atractylodes rhizome, 5-10 parts of rhizoma pinellinae praeparata, 5-10 parts of pericarpium citri reticulatae, 5-10 parts of stiff silkworm, 15-20 parts of fried malt, 5-10 parts of cassia twig, 10-20 parts of white paeony root, 10-15 parts of vinegar-processed nutgrass galingale rhizome and 5-10 parts of roasted liquorice.

4. The use of a traditional Chinese medicine composition for treating migraine according to any one of claims 1-3 in preparing a medicament for treating migraine.

5. A medicament for treating migraine, which is characterized by comprising the traditional Chinese medicine composition for treating migraine according to any one of claims 1-3 and pharmaceutically acceptable auxiliary materials.

6. The medicine for treating migraine according to claim 5, wherein the medicine is in the form of decoction, granule, pill, paste, capsule, tablet, tea, suspension, powder or oral liquid.

7. The method for preparing the medicine for treating migraine according to claim 5 or 6, wherein the medicine is a traditional Chinese medicine decoction, and the preparation method is as follows:

Weighing the raw materials according to the weight portion, cleaning, drying, cutting, crushing, sieving and uniformly mixing;

Adding clear water which is 6-8 times the volume of the raw material medicine obtained in the first step, soaking for 30-50 minutes, boiling with strong fire, continuously decocting with slow fire for 30-45 minutes, filtering with a traditional Chinese medicine sieve to obtain a first filtrate, adding water into residues without the residues, boiling with strong fire, continuously decocting with slow fire for 30-45 minutes, filtering with a traditional Chinese medicine sieve to obtain a second filtrate, and combining the first filtrate and the second filtrate to obtain the traditional Chinese medicine decoction.

8. The method for preparing the medicine for treating migraine according to claim 5 or 6, wherein the medicine is a paste, and the preparation method is as follows:

Weighing the raw materials according to the weight portion, cleaning, drying, cutting, crushing, sieving and uniformly mixing;

Adding clear water which is 6-8 times the volume of the raw material medicine obtained in the first step, soaking for 30-50 minutes, boiling with strong fire, continuously decocting with slow fire for 30-45 minutes, filtering with a traditional Chinese medicine sieve to obtain a first filtrate, adding water into the residues without the residues, boiling with strong fire, continuously decocting with slow fire for 30-45 minutes, filtering with a traditional Chinese medicine sieve to obtain a second filtrate, and combining the first filtrate and the second filtrate;

And thirdly, decocting the combined filtrate obtained in the second step with small fire at 100-120 ℃, continuously stirring, and pouring the paste into a dry vessel when the medicine is hung on the flag to obtain the paste.