CN119818598A - An oral Chinese medicinal composition for treating vitiligo, and its preparation method - Google Patents

An oral Chinese medicinal composition for treating vitiligo, and its preparation method Download PDF

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CN119818598A
CN119818598A CN202510130010.5A CN202510130010A CN119818598A CN 119818598 A CN119818598 A CN 119818598A CN 202510130010 A CN202510130010 A CN 202510130010A CN 119818598 A CN119818598 A CN 119818598A
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parts
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chinese medicine
treating vitiligo
composition
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陈维文
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Beijing Traditional Chinese Medicine Hospital
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Beijing Traditional Chinese Medicine Hospital
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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides a traditional Chinese medicine oral composition for treating vitiligo and a preparation method thereof. The Chinese medicinal composition is prepared from semen cuscutae, schisandra chinensis, fructus polygoni orientalis, semen astragali complanati, radix clematidis, duckweed, folium corni, ligusticum wallichii, rhizoma cyperi, liquorice, cinnamon and forged oyster by taking the raw materials as raw materials and carrying out proper weight proportions, wherein the semen cuscutae, the semen astragali complanati and the folium corni are used for tonifying liver and kidney, the radix clematidis and the duckweed are used for dispelling wind and dredging collaterals, the fructus schisandrae and the calcined oyster are used for astringing and inducing astringents, the rhizoma cyperi, the ligusticum wallichii and the fructus polygoni orientalis are used for regulating qi and activating blood, and the prepared liquorice are used for harmonizing the medicines. The medicines are combined together to realize synergistic effect, and the effects of tonifying liver and kidney, regulating qi and blood, promoting blood circulation and dispelling wind are achieved, so that the decolored part of a patient can be promoted to be complex, the white spot area of the patient can be reduced, and the bad emotion of the patient can be improved through integrally regulating qi and blood of viscera.

Description

An oral Chinese medicinal composition for treating vitiligo, and its preparation method
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine oral composition for treating vitiligo and a preparation method thereof.
Background
Vitiligo is a disease caused by idiopathic injury of acquired organism melanocytes, which is caused by the fact that the melanocytes cannot normally exert their physiological effects under the action of one or more reasons, resulting in systemic or local depigmentation of skin. The skin injury part is mainly obvious different from the normal skin color of the organism. The disease has a global incidence of 0.5% -2%, is a widely-existing skin pigment loss disease, and is directly caused by that the skin damage part causes hair follicles or functional melanocytes in skin tissues to not normally exert physiological effects, so that the skin is generalized or has local skin leukoplakia.
Because the pathogenesis of the vitiligo is not completely elucidated, a specific medicine for completely curing the vitiligo is not available at present, the existing treatment methods such as phototherapy, medicine treatment, transplantation treatment and the like have certain effects, but the monotherapy often has difficult to achieve ideal effects, and in addition, the existing treatment medicines such as calcineurin inhibitors, glucocorticoid, vitamin D3 derivatives and the like have no indication of the vitiligo, and the problems of large side effects exist. Although new technologies such as JAK inhibitors, hair follicle melanocyte transplantation, etc. have emerged in recent years, efficacy evaluation and clinical application and popularization of these technologies still face challenges, for example, safety and long-term efficacy of JAK inhibitors still require more clinical observation and research. The vitiligo treatment usually takes a long time to take effect, the curative effect varies from person to person, the compound color effect is poor after partial patients are treated, even recrudescence occurs, and according to statistics, about 40% of patients relapse within one year after treatment, and the compound color rate is lower. Thus, even if the condition is controlled after treatment, it may recur or spread due to various causative factors, requiring continued, long-term attention and management, and even if the condition is controlled during treatment, white spots may reappear once the treatment is stopped. The existing treatment method can not fundamentally eliminate the cause of disease, only can temporarily control the condition of the patient, and in addition, patients with vitiligo often generate anxiety, sped, dysphoria and other emotions due to the influence of the condition, the emotion fluctuation can prolong the treatment period, increase the treatment difficulty, and the treatment cost is higher, especially for patients needing long-term treatment, the economic burden is higher.
The traditional Chinese medicine and ethnic medicine for treating the vitiligo comprise vitiligo pills (capsules), bailing tablets, white erosion pills, tablets at Bai Babu-stage of expelling, compound vernonia anthelmintica tablets and the like, but the traditional Chinese medicine and ethnic medicine are difficult to achieve consistent ideal states in multiple factors such as using effect, treatment period, economic cost and the like, so that the clinical application and popularization are limited. Therefore, a traditional Chinese medicine formula for treating the vitiligo is urgently needed, the use effect is obviously improved, the treatment time is shortened, and the recurrence is reduced.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the traditional Chinese medicine oral composition for treating the vitiligo, which has the advantages of obvious effect, short treatment time and low recurrence rate, and the preparation method thereof. The traditional Chinese medicine composition disclosed by the invention can promote the multiple colors of decolored parts of a patient, reduce the white spot area and lighten the color of the patient, completely eliminate part of the white spot area, and simultaneously improve the overall state of the patient and inhibit relapse by integrally regulating qi and blood of viscera.
The technical scheme adopted by the invention is as follows:
The first aspect of the invention provides a traditional Chinese medicine oral composition for treating vitiligo, which comprises the following raw material components:
10-25 parts of semen cuscutae, 5-15 parts of shizandra berry, 5-20 parts of fructus polygoni orientalis, 5-20 parts of semen astragali complanati, 5-20 parts of radix clematidis, 3-10 parts of duckweed, 5-20 parts of Chinese holly leaf, 5-20 parts of ligusticum wallichii, 5-20 parts of rhizoma cyperi, 5-20 parts of liquorice, 5-20 parts of cinnamon and 5-20 parts of forged oyster.
Further preferably, the raw material components of the traditional Chinese medicine oral composition for treating vitiligo comprise:
17.5 parts of semen cuscutae, 10 parts of shizandra berry, 12.5 parts of fructus polygoni orientalis, 12.5 parts of semen astragali complanati, 12.5 parts of radix clematidis, 6.5 parts of duckweed, 12.5 parts of Chinese holly leaf, 12.5 parts of ligusticum wallichii, 12.5 parts of rhizoma cyperi, 12.5 parts of liquorice, 12.5 parts of cinnamon and 12.5 parts of calcined oyster.
The Glycyrrhrizae radix is radix Glycyrrhizae Preparata.
The second aspect of the invention provides a preparation method of the Chinese medicinal oral composition for treating vitiligo, which comprises the following steps of:
(S1) taking the raw material components according to parts by weight, uniformly mixing, and crushing to obtain traditional Chinese medicine powder;
(S2) adding water into the traditional Chinese medicine powder obtained in the step S1 for reflux extraction to obtain raw material liquid medicine;
(S3) filtering and concentrating the raw material liquid medicine obtained in the step S2 to obtain a concentrate;
(S4) drying and crushing the concentrate obtained in the step S3 to obtain the traditional Chinese medicine oral composition.
In the step (S1), the particle size of the traditional Chinese medicine powder is 20-60 meshes.
In the step (S2), the mass ratio of the traditional Chinese medicine powder to the added water is 1:4-1:8.
In the step (S2), the reflux extraction time is 1-2h.
In step (S2), the reflux extraction is repeated 2 to 3 times.
In the step (S3), the concentration is reduced pressure concentration to thick paste with the relative density of 1.30-1.35.
In step (S4), the drying temperature is 80-120 ℃.
Semen Cuscutae is sweet in flavor and warm in nature. Nourishing liver and kidney, securing essence, reducing urination, preventing abortion, improving eyesight, and relieving diarrhea. Can be used for treating sexual impotence, spermatorrhea, frequent urination, soreness of waist and knees, dizziness, tinnitus, kidney deficiency, fetal movement disorder, spleen and kidney deficiency, diarrhea, and vitiligo.
Schisandra chinensis, fructus Schisandrae chinensis, sour and sweet in taste and warm in nature. Astringing lung, nourishing kidney, promoting fluid production, inducing sweat, and astringing essence. For cough and dyspnea due to lung deficiency, thirst due to dry mouth, spontaneous sweating, night sweat, fatigue, emaciation, nocturnal emission, chronic diarrhea and dysentery.
Water safflower seed is salty in taste and slightly cold in nature. Dispel blood and relieve symptoms, remove food retention and relieve pain. Can be used for treating lump, gall, dyspepsia, and gastralgia.
Semen astragali Complanati is sweet in taste and warm in nature. Warm and nourish liver and kidney, arrest spontaneous emission, reduce urination and improve vision. Can be used for treating lumbago due to kidney deficiency, spermatorrhea, premature ejaculation, leukorrhagia, dribbling urine, dizziness, and blurred vision.
Clematis chinensis is pungent and salty in flavor and warm in nature. Has effects of dispelling pathogenic wind, removing dampness, dredging collaterals, relieving pain, and eliminating bone sticking. It can be used for treating rheumatalgia, difficulty in flexion and extension, lumbago, gonalgia, numbness of limbs, and tetanus.
Du Zhu, pungent in flavor and cold in nature. Disperse wind-heat, promote eruption and induce diuresis. Can be used for treating measles, rubella pruritus, edema, and oliguria.
Chinese holly leaf, bitter in flavor and cool in nature. Clear heat and nourish yin, calm liver and nourish kidney. Can be used for treating tuberculosis hemoptysis, hectic fever due to bone steaming, dizziness, and hypertension.
Chuan Xiong, is pungent in flavor and warm in nature. Promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, chest pain, hypochondrium pain, traumatic injury, headache, and rheumatalgia.
Nutgrass galingale rhizome, rhizoma Cyperi, slightly bitter, sweet and flat in nature. Has effects of dispersing stagnated liver qi, promoting blood circulation and regulating menstruation.
Licorice root, radix Glycyrrhizae, sweet in taste and neutral in nature. Spleen invigorating, qi replenishing, heat and toxic materials clearing away, phlegm eliminating, cough relieving, pain relieving, and medicines regulating. Can be used for treating weakness of spleen and stomach, listlessness, debilitation, palpitation, short breath, cough with excessive phlegm, abdominal pain, limb spasm, carbuncle, swelling, sore and toxic materials, and relieving drug toxicity and intensity.
Rou Gui is pungent and sweet in flavor and is hot in nature. Tonifying fire and invigorating yang, inducing fire to enter the source, dispelling cold and relieving pain, and promoting blood circulation and dredging channels. Can be used for treating sexual impotence, cold womb, cold pain of waist and knee, asthma due to kidney deficiency, dizziness due to yang deficiency, conjunctival congestion, pharyngalgia, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, running dolphin, amenorrhea, and dysmenorrhea.
Calcined oyster is salty in taste and slightly cold in nature. Astringing yin and suppressing yang, stopping sweat and astringing essence, resolving phlegm and softening hard mass. For convulsion, epilepsy, spontaneous sweat, night sweat, spermatorrhea, stranguria with turbid urine, metrorrhagia, leukorrhagia, scrofula, goiter, dizziness, tinnitus, abdominal mass, and gastralgia. Calcined oyster has the effect of astringing and inducing astringency.
The invention has the following beneficial effects:
The invention provides a traditional Chinese medicine oral composition for treating leucoderma, which is prepared from raw materials including semen cuscutae, fructus schisandrae, fructus polygoni orientalis, semen astragali complanati, radix clematidis, duckweed, folium corni, ligusticum wallichii, rhizoma cyperi, liquorice, cinnamon and calcined oyster by proper weight proportions, wherein semen cuscutae, semen astragali complanati and folium corni invigorate liver and kidney, radix clematidis and duckweed dispel wind and remove meridian obstruction, fructus schisandrae chinensis and calcined oyster are astringed and astringe, rhizoma cyperi, ligusticum wallichii and fructus polygoni orientalis are used for regulating qi and activating blood, and prepared liquorice are used for harmonizing the medicines. The medicines are combined together to realize synergistic effect, and the effects of tonifying liver and kidney, regulating qi and blood, promoting blood circulation and dispelling wind are achieved, so that the decolored part of a patient can be promoted to be complex, the white spot area of the patient can be reduced, and the bad emotion of the patient can be improved through integrally regulating qi and blood of viscera. In addition, the medicine is used in the treatment process of vitiligo patients, reduces the medicine use amount compared with the prior medicine on the premise of ensuring the curative effect, reduces the medicine cost, shortens the medicine application time and is beneficial to clinical popularization and application.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It will be apparent that the described embodiments are only some, but not all, embodiments of the invention. All other embodiments, based on the examples herein, which are within the scope of the invention as defined by the claims, will be within the scope of the invention as defined by the claims.
Unless otherwise specified, all reagents involved in embodiments of the invention are commercially available products and are commercially available.
In the following examples, 1g was represented by 1 part by weight.
Example 1
The embodiment provides a traditional Chinese medicine oral composition for treating vitiligo, which comprises the following raw material components:
10 parts of semen cuscutae, 15 parts of shizandra berry, 5 parts of fructus polygoni orientalis, 20 parts of semen astragali complanati, 5 parts of radix clematidis, 10 parts of duckweed, 5 parts of Chinese holly leaf, 20 parts of ligusticum wallichii, 5 parts of rhizoma cyperi, 20 parts of honey-fried licorice root, 5 parts of cinnamon and 20 parts of calcined oyster.
The preparation method of the traditional Chinese medicine oral composition for treating vitiligo specifically comprises the following steps:
(S1) taking the raw material components according to parts by weight, uniformly mixing, and crushing to obtain traditional Chinese medicine powder with the particle size of 20 meshes;
(S2) adding 4 times of water into the traditional Chinese medicine powder obtained in the step S1 for reflux extraction for 2 hours, repeating the reflux extraction for 2 times, and combining the extracting solutions to obtain raw material liquid medicine;
(S3) filtering the raw material liquid medicine obtained in the step S2, and concentrating the filtered raw material liquid medicine under reduced pressure to obtain thick paste with the relative density of 1.30, namely a concentrate;
(S4) drying and crushing the concentrate obtained in the step S3 to obtain the traditional Chinese medicine oral composition.
Example 2
The embodiment provides a traditional Chinese medicine oral composition for treating vitiligo, which comprises the following raw material components:
25 parts of semen cuscutae, 5 parts of shizandra berry, 20 parts of fructus polygoni orientalis, 5 parts of semen astragali complanati, 20 parts of radix clematidis, 3 parts of duckweed, 20 parts of Chinese holly leaf, 5 parts of ligusticum wallichii, 20 parts of nutgrass galingale rhizome, 5 parts of honey-fried licorice root, 20 parts of cinnamon and 5 parts of calcined oyster.
The preparation method of the traditional Chinese medicine oral composition for treating vitiligo specifically comprises the following steps:
(S1) taking the raw material components according to parts by weight, uniformly mixing, and crushing to obtain traditional Chinese medicine powder with the particle size of 60 meshes;
(S2) adding 8 times of water into the traditional Chinese medicine powder obtained in the step S1 for reflux extraction for 1h, repeating the reflux extraction for 3 times, and combining the extracting solutions to obtain raw material liquid medicine;
(S3) filtering the raw material liquid medicine obtained in the step S2, and concentrating the filtered raw material liquid medicine under reduced pressure to obtain thick paste with the relative density of 1.35, namely a concentrate;
(S4) drying and crushing the concentrate obtained in the step S3 to obtain the traditional Chinese medicine oral composition.
Example 3
The embodiment provides a traditional Chinese medicine oral composition for treating vitiligo, which comprises the following raw material components:
17.5 parts of semen cuscutae, 10 parts of shizandra berry, 12.5 parts of fructus polygoni orientalis, 12.5 parts of semen astragali complanati, 12.5 parts of radix clematidis, 6.5 parts of duckweed, 12.5 parts of Chinese holly leaf, 12.5 parts of ligusticum wallichii, 12.5 parts of rhizoma cyperi, 12.5 parts of liquorice, 12.5 parts of cinnamon and 12.5 parts of calcined oyster.
The preparation method of the traditional Chinese medicine oral composition for treating vitiligo specifically comprises the following steps:
(S1) taking the raw material components according to parts by weight, uniformly mixing, and crushing to obtain traditional Chinese medicine powder with the particle size of 40 meshes;
(S2) adding 6 times of water into the traditional Chinese medicine powder obtained in the step S1 for reflux extraction for 1.5h, repeating the reflux extraction for 2 times, and combining the extracting solutions to obtain raw material liquid medicine;
(S3) filtering the raw material liquid medicine obtained in the step S2, and concentrating the filtered raw material liquid medicine under reduced pressure to obtain thick paste with the relative density of 1.32, namely a concentrate;
(S4) drying and crushing the concentrate obtained in the step S3 to obtain the traditional Chinese medicine oral composition.
Example 4
The embodiment provides a traditional Chinese medicine oral composition for treating vitiligo, which comprises the following raw material components:
17.5 parts of semen cuscutae, 10 parts of shizandra berry, 12.5 parts of fructus polygoni orientalis, 12.5 parts of semen astragali complanati, 12.5 parts of radix clematidis, 6.5 parts of duckweed, 12.5 parts of Chinese holly leaf, 12.5 parts of ligusticum wallichii, 12.5 parts of rhizoma cyperi, 12.5 parts of liquorice, 12.5 parts of cinnamon and 12.5 parts of calcined oyster.
The preparation method of the traditional Chinese medicine oral composition for treating vitiligo specifically comprises the following steps:
(S1) taking the raw material components according to parts by weight, uniformly mixing, and crushing to obtain traditional Chinese medicine powder with the particle size of 20-60 meshes;
(S2) adding 4-8 times of water into the traditional Chinese medicine powder obtained in the step S1 for decoction for 1h to obtain a traditional Chinese medicine liquid, namely the traditional Chinese medicine oral composition.
Example 5
The embodiment provides a traditional Chinese medicine oral composition for treating vitiligo, which comprises the following raw material components:
17.5 parts of semen cuscutae, 10 parts of shizandra berry, 12.5 parts of fructus polygoni orientalis, 12.5 parts of semen astragali complanati, 12.5 parts of radix clematidis, 6.5 parts of duckweed, 12.5 parts of Chinese holly leaf, 12.5 parts of ligusticum wallichii, 12.5 parts of rhizoma cyperi, 12.5 parts of liquorice, 12.5 parts of cinnamon and 12.5 parts of calcined oyster.
The preparation method of the traditional Chinese medicine oral composition for treating vitiligo specifically comprises the following steps:
(S1) taking the raw material components according to parts by weight, uniformly mixing, and crushing to obtain traditional Chinese medicine powder with the particle size of 40 meshes;
(S2) adding 6 times of water into the traditional Chinese medicine powder obtained in the step S1 for reflux extraction for 1.5 hours, and combining the extracting solutions to obtain raw material liquid medicine;
(S3) filtering the raw material liquid medicine obtained in the step S2, and concentrating the filtered raw material liquid medicine under reduced pressure to obtain thick paste with the relative density of 1.33, namely a concentrate;
(S4) drying and crushing the concentrate obtained in the step S3 to obtain the traditional Chinese medicine oral composition.
Experimental example
The clinical efficacy of the oral Chinese medicinal composition obtained in example 3 for treating vitiligo is evaluated. 45 patients who are diagnosed with vitiligo according to the diagnosis standard of the diagnosis and treatment consensus (2021 edition) issued by the national institute of Chinese and Western medicine and who are in the clinic of Beijing traditional Chinese medicine hospitals from 1 month of 2023 to 1 month of 2024 are observed, 45 patients are orally taken according to the oral scheme of the traditional Chinese medicine, simultaneously, the oral scheme is matched with the irradiation of narrow-spectrum UVB for 1 time per week, 6 months (24 weeks) are taken as an observation period, the area score index (VASI) of vitiligo is taken as a main observation index, and the nimodipine method is adopted to calculate the change rate of the area score index (VASI) of the main observation index before and after treatment, so that the curative effect evaluation is carried out.
Nimodipine method calculation formula, efficacy index (n) = (pre-treatment VASI score-post-treatment VASI score)/pre-treatment VASI score x 100%.
Recovery, namely, the white spots completely recover the normal skin color;
The effect is obvious that white spots are obviously reduced and pigment is regenerated (n is more than or equal to 50 percent);
Effective that white spots have reduced and regenerated pigment (50% > n is more than or equal to 10%);
No white spots were reduced and pigment was regenerated (n < 10%).
The results are shown in Table 1.
TABLE 1 evaluation of effects of the oral Chinese medicinal composition obtained in EXAMPLE 3
As can be seen from Table 1, 45 patients are cured 2 cases, the cure rate is 4.4%, the effective rate is 73.3% for 33 cases, and 22.2% for 10 cases, so that the Chinese medicinal oral composition obtained in example 3 has a good curative effect.
2. Clinical cases:
The traditional Chinese medicine composition has good clinical curative effect, and obvious adverse reactions do not occur in the treatment process of the traditional Chinese medicine of all patients.
Typical cases:
Typical case 1 is that men, 45 years old, 2023, 4 months and 2 days of diagnosis, patients with vitiligo for 3 years, plain irritability, white spots with different sizes at the trunk and the back of the hand, are treated by tacrolimus ointment externally, and compound glycyrrhizin is orally taken for aggravation in the near half year. After the traditional Chinese medicine composition of the embodiment 3 is used for treating for 5 months, all white spots become shallow, most white spots are reduced in advance, the rash area is reduced by more than 80%, the medicine is stopped for 3 months and 6 months for follow-up, and no recurrence exists.
Typical case 2 is that women, 38 years old, patients see the doctor in the 6 th year and 18 th year of 2023, the patient has 10 years of vitiligo, plain pressure is high, white spots with different sizes at the abdomen, back and the like are treated by external use such as tacrolimus ointment, halometasone ointment, compound calicumin tincture and the like, oral administration of glucocorticoid, compound glycyrrhizin, total white peony root glycoside tablets and the like, and the effect is poor and aggravated in the last half year. After the traditional Chinese medicine composition of the embodiment 3 is used for treating for 1 year, the white spot area is reduced by more than 60% compared with the prior white spot area, meanwhile, the complaint emotion of a patient is improved relatively before, and no recurrence occurs after 3 months of follow-up.
Typical case 3 is that men, 38 years old, patients see the doctor in 2024 8 months 2 days, the patient gets vitiligo for 5 years, plain pressure is high, and the spots with different sizes at various positions of scalp, corners of mouth, hands and back are treated by external application of halominosone ointment and injection for 1 time per month, compound glycyrrhizin is orally taken, and the patients are aggravated in the near half year. After the traditional Chinese medicine composition of the embodiment 1 is used for treating for 4 months, white spots become shallow, partial white spots become light red, the area is reduced earlier, and meanwhile, the complaint emotion of a patient is improved earlier.
Typical case 4, men, 20 years old, 10 months 21 days 2024, patients with vitiligo for 3 months, white spots on the inner side of the right upper limbs and white spots on the inner side of the right palms, after 4 months of treatment with the traditional Chinese medicine composition of the embodiment 2 of the invention, the white spots are reduced in area and visible in color islands.
Typical cases 5, women, 52 years old, 10 months and 14 days of 2024, patients with vitiligo for more than 1 year, and white spots on the trunk and left lower leg, were treated by oral administration of traditional Chinese medicine and 308 local irradiation, the effect is poor, and after 2 months of treatment by adopting the traditional Chinese medicine composition of the embodiment 1, the white spot area is reduced relatively before, and the visible color islands are formed.
The foregoing is merely illustrative of the present invention, and the present invention is not limited thereto, and any person skilled in the art will readily recognize that variations or substitutions are within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (10)

1.一种用于治疗白癜风的中药内服组合物，其特征在于，原料组分包括：1. A Chinese medicine oral composition for treating vitiligo, characterized in that the raw material components include: 菟丝子10-25重量份、五味子5-15重量份、水红花子5-20重量份、沙苑子5-20重量份、威灵仙5-20重量份、浮萍3-10重量份、枸骨叶5-20重量份、川芎5-20重量份、香附5-20重量份、甘草5-20重量份、肉桂5-20重量份、锻牡蛎5-20重量份。10-25 weight parts of Cuscuta seeds, 5-15 weight parts of Schisandra chinensis, 5-20 weight parts of Polygonum multiflorum seeds, 5-20 weight parts of Astragalus membranaceus seeds, 5-20 weight parts of Clematis chinensis, 3-10 weight parts of Duckweed, 5-20 weight parts of Holly leaves, 5-20 weight parts of Chuanxiong, 5-20 weight parts of Cyperus rotundus, 5-20 weight parts of Licorice, 5-20 weight parts of cinnamon bark, and 5-20 weight parts of Oyster shell. 2.根据权利要求1所述的用于治疗白癜风的中药内服组合物，其特征在于，原料组分包括：2. The Chinese medicinal composition for treating vitiligo according to claim 1, wherein the raw material components include: 菟丝子17.5重量份、五味子10重量份、水红花子12.5重量份、沙苑子12.5重量份、威灵仙12.5重量份、浮萍6.5重量份、枸骨叶12.5重量份、川芎12.5重量份、香附12.5重量份、甘草12.5重量份、肉桂12.5重量份、锻牡蛎12.5重量份。17.5 parts by weight of Cuscuta seeds, 10 parts by weight of Schisandra chinensis, 12.5 parts by weight of Polygonum multiflorum, 12.5 parts by weight of Astragalus membranaceus, 12.5 parts by weight of Clematidis, 6.5 parts by weight of Duckweed, 12.5 parts by weight of Holly leaves, 12.5 parts by weight of Ligusticum chuanxiong, 12.5 parts by weight of Cyperus rotundus, 12.5 parts by weight of Licorice, 12.5 parts by weight of Cinnamon bark, and 12.5 parts by weight of Oyster shell. 3.根据权利要求1所述的用于治疗白癜风的中药内服组合物，其特征在于，所述甘草为炙甘草。3. The Chinese medicinal composition for treating vitiligo according to claim 1, wherein the licorice is roasted licorice. 4.根据权利要求1-3任一项所述的用于治疗白癜风的中药内服组合物的制备方法，其特征在于，包括如下步骤：4. A method for preparing a Chinese medicinal composition for treating vitiligo according to any one of claims 1 to 3, characterized in that it comprises the following steps: （S1）按重量份取上述各原料组分，混合均匀，粉碎，得到中药粉；(S1) taking the above raw material components by weight, mixing them evenly, and crushing them to obtain Chinese medicine powder; （S2）将步骤S1得到的所述中药粉加水进行回流提取，得到原料药液；(S2) adding water to the Chinese medicine powder obtained in step S1 for reflux extraction to obtain a raw material medicine solution; （S3）将步骤S2得到的所述原料药液滤过、浓缩，得到浓缩物；(S3) filtering and concentrating the raw material drug solution obtained in step S2 to obtain a concentrate; （S4）将步骤S3得到的浓缩物进行干燥、粉碎，得到中药内服组合物。(S4) Drying and crushing the concentrate obtained in step S3 to obtain a Chinese medicine composition for internal use. 5.根据权利要求4所述的用于治疗白癜风的中药内服组合物的制备方法，其特征在于，步骤（S1）中，所述中药粉的粒径为20-60目。5. The method for preparing a Chinese medicine internal composition for treating vitiligo according to claim 4, characterized in that in step (S1), the particle size of the Chinese medicine powder is 20-60 mesh. 6.根据权利要求4所述的用于治疗白癜风的中药内服组合物的制备方法，其特征在于，步骤（S2）中，所述中药粉与添加水的质量之比为 1:4-1:8。6. The method for preparing a Chinese medicine internal composition for treating vitiligo according to claim 4, characterized in that in step (S2), the mass ratio of the Chinese medicine powder to the added water is 1:4-1:8. 7.根据权利要求4所述的用于治疗白癜风的中药内服组合物的制备方法，其特征在于，步骤（S2）中，所述回流提取的时间为1-2h。7. The method for preparing the Chinese medicinal internal composition for treating vitiligo according to claim 4, characterized in that in step (S2), the reflux extraction time is 1-2 hours. 8.根据权利要求7所述的用于治疗白癜风的中药内服组合物的制备方法，其特征在于，步骤（S2）中，所述回流提取重复进行2-3次。8. The method for preparing a traditional Chinese medicine internal composition for treating vitiligo according to claim 7, characterized in that in step (S2), the reflux extraction is repeated 2-3 times. 9.根据权利要求4所述的用于治疗白癜风的中药内服组合物的制备方法，其特征在于，步骤（S3）中，所述浓缩为减压浓缩至相对密度为1.30-1.35的稠膏。9. The method for preparing a Chinese medicinal internal composition for treating vitiligo according to claim 4, characterized in that in step (S3), the concentration is concentrated under reduced pressure to a thick paste with a relative density of 1.30-1.35. 10.根据权利要求4所述的用于治疗白癜风的中药内服组合物的制备方法，其特征在于，步骤（S4）中，所述干燥的温度为80-120℃。10. The method for preparing the Chinese medicinal internal composition for treating vitiligo according to claim 4, characterized in that in step (S4), the drying temperature is 80-120°C.
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