CN1196479C - 吸入形式的苯并茚前列腺素制剂的用途 - Google Patents

吸入形式的苯并茚前列腺素制剂的用途 Download PDF

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Publication number
CN1196479C
CN1196479C CNB008051089A CN00805108A CN1196479C CN 1196479 C CN1196479 C CN 1196479C CN B008051089 A CNB008051089 A CN B008051089A CN 00805108 A CN00805108 A CN 00805108A CN 1196479 C CN1196479 C CN 1196479C
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Prior art keywords
benzindene
pulmonary
aerosolized
dose
use according
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Expired - Lifetime
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CNB008051089A
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English (en)
Chinese (zh)
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CN1379665A (zh
Inventor
G·克卢捷
J·格罗
M·韦德
R·E·帕克
J·E·劳埃德
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United Therapeutics Corp
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United Therapeutics Corp
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Publication of CN1379665A publication Critical patent/CN1379665A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB008051089A 1999-03-18 2000-03-17 吸入形式的苯并茚前列腺素制剂的用途 Expired - Lifetime CN1196479C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12499999P 1999-03-18 1999-03-18
US60/124,999 1999-03-18

Publications (2)

Publication Number Publication Date
CN1379665A CN1379665A (zh) 2002-11-13
CN1196479C true CN1196479C (zh) 2005-04-13

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ID=22417774

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CNB008051089A Expired - Lifetime CN1196479C (zh) 1999-03-18 2000-03-17 吸入形式的苯并茚前列腺素制剂的用途

Country Status (13)

Country Link
US (2) US6521212B1 (https=)
EP (1) EP1161234B1 (https=)
JP (2) JP4819224B2 (https=)
KR (1) KR100750384B1 (https=)
CN (1) CN1196479C (https=)
AT (1) ATE245979T1 (https=)
AU (1) AU4082700A (https=)
CA (1) CA2365890C (https=)
DE (1) DE60004181T2 (https=)
DK (1) DK1161234T3 (https=)
ES (1) ES2203449T3 (https=)
PT (1) PT1161234E (https=)
WO (1) WO2000054758A2 (https=)

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US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
US20090124697A1 (en) * 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
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ATE441418T1 (de) * 2003-12-16 2009-09-15 United Therapeutics Corp Verwendung von treprostinil zur verbesserung der nierenfunktion
WO2005099680A2 (en) * 2004-04-12 2005-10-27 United Therapeutics, Inc. Use of treprostinil to treat neuropathic diabetic foot ulcers
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WO2007067570A1 (en) * 2005-12-05 2007-06-14 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of disease
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CN101903324B (zh) 2007-12-17 2013-07-03 联合治疗公司 一种制备Remodulin中的活性成分曲前列素的改良方法
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CN102164487A (zh) * 2008-09-25 2011-08-24 阿拉迪姆公司 曲前列素的深肺部递送
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CN103193627B (zh) 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CN103193626B (zh) 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
US9387214B2 (en) 2012-01-13 2016-07-12 United Therapeutics Corporation Method of identifying therapies for pulmonary hypertension
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CN109608326A (zh) 2013-03-15 2019-04-12 联合治疗公司 曲前列环素的盐
JP6263604B2 (ja) 2013-03-25 2018-01-17 ユナイテッド セラピューティクス コーポレイション チオールリンカーを持つ、ペグ化型のプロスタサイクリン化合物の製造方法
ES2860975T3 (es) 2013-10-25 2021-10-05 Insmed Inc Compuestos de prostaciclina
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US9593061B2 (en) 2014-10-20 2017-03-14 United Therapeutics Corporation Synthesis of intermediates for producing prostacyclin derivatives
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Also Published As

Publication number Publication date
CA2365890A1 (en) 2000-09-21
KR20010108352A (ko) 2001-12-07
CA2365890C (en) 2010-09-21
EP1161234A2 (en) 2001-12-12
DE60004181D1 (de) 2003-09-04
WO2000054758A2 (en) 2000-09-21
JP4819224B2 (ja) 2011-11-24
ES2203449T3 (es) 2004-04-16
AU4082700A (en) 2000-10-04
WO2000054758A3 (en) 2001-02-08
DK1161234T3 (da) 2003-11-24
ATE245979T1 (de) 2003-08-15
JP2002539154A (ja) 2002-11-19
DE60004181T2 (de) 2004-04-15
KR100750384B1 (ko) 2007-08-17
PT1161234E (pt) 2003-12-31
US6756033B2 (en) 2004-06-29
JP2011201907A (ja) 2011-10-13
EP1161234B1 (en) 2003-07-30
US6521212B1 (en) 2003-02-18
CN1379665A (zh) 2002-11-13
US20030053958A1 (en) 2003-03-20

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