CN1191818C - Cleaning products with improved moisturization - Google Patents

Cleaning products with improved moisturization Download PDF

Info

Publication number
CN1191818C
CN1191818C CN 98806749 CN98806749A CN1191818C CN 1191818 C CN1191818 C CN 1191818C CN 98806749 CN98806749 CN 98806749 CN 98806749 A CN98806749 A CN 98806749A CN 1191818 C CN1191818 C CN 1191818C
Authority
CN
Grant status
Grant
Patent type
Prior art keywords
water
conditioning
skin
acid
product
Prior art date
Application number
CN 98806749
Other languages
Chinese (zh)
Other versions
CN1261789A (en )
Inventor
J·A·瓦格纳
E·J·哈森诺尔
T·J·弗勒
Original Assignee
普罗克特和甘保尔公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/02Cosmetics or similar toilet preparations characterised by special physical form
    • A61K8/0208Tissues; Wipes; Patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/12Preparations containing hair conditioners

Abstract

本发明涉及基本上干燥的一次性个人清洁产品,用于清洁和调理皮肤或毛发。 The present invention relates to a substantially dry disposable personal cleansing product for cleansing and conditioning the skin or hair. 使用者通过用水润湿该干燥产品来使用这种产品。 The user is moistened with water and dried by the use of this product to product. 该产品包含水不溶性基质、起泡型表面活性剂和调理剂乳液。 The product comprises a water insoluble substrate, a lathering surfactant and a conditioning emulsion. 本发明还包括用该产品清洁和调理皮肤或毛发的方法以及包括生产该产品的方法。 The present invention further includes a method of cleansing and conditioning product with the skin or hair and a method for producing the product includes.

Description

具有改进增湿性能的清洁产品 With improved performance humidifier cleaning products

技术领域 FIELD

本发明涉及一种基本上干燥的一次性个人清洁产品,适用于清洁和调理皮肤或毛发。 The present invention relates to a substantially dry disposable personal cleansing products for cleansing and conditioning the skin or hair. 消费者可通过把干燥产品用水润湿进行使用。 Consumers can use the products through the drying moistened with water. 产品包含水不溶性基质、起泡型表面活性剂和调理乳液,调理乳液包含(i)包含油溶性试剂的外相和(ii)包含水溶性调理剂的内相。 Product comprising a water insoluble substrate, a lathering surfactant and a conditioning emulsion, conditioning emulsion comprises (i) the external phase comprising oil soluble agents and (ii) an internal phase comprising water soluble conditioning agents. 本产品可有效地将水溶性调理剂输送至皮肤或毛发上。 This product can effectively be delivered to the water soluble conditioning agents onto the skin or hair.

使用基质可在低表面活性剂含量下加强起泡,加大清洁和剥脱作用,并使水溶性调理成分的传递和沉积达到最佳。 Use of a matrix can be strengthened at low surfactant foaming agent content, to increase the cleaning action and exfoliation, and delivery and deposition of conditioning ingredients to achieve the best water-soluble. 因此,本发明提供了一种有效的清洁产品,其中使用低含量的表面活性剂,因而刺激很小,通过输送水溶性调理剂和油溶性调理剂而提供优良的调理性能。 Accordingly, the present invention provides an effective cleaning product, wherein the surfactant content is low, and thus stimulate small, and excellent conditioning properties provided by the transport water soluble conditioning agent and oil soluble conditioning agent.

本发明还包括含有各种可传递到皮肤或毛发上的活性成分的产品。 The present invention also includes a variety of products can be transferred to the active ingredient on the skin or hair.

本发明还包括使用本发明的产品清洁和增湿皮肤和毛发的方法以及生产这些产品的方法。 The present invention further includes the use of a cleaning product of the present invention and the method of humidification of the skin and hair and methods of these products.

发明背景传统上,个人清洁和调理产品以各种形式如块皂、膏霜、水剂和凝胶进行销售。 Background Traditionally invention, personal cleansing and conditioning products in a variety of forms such as bar soaps, creams, lotions and gels sold. 这些清洁配方曾尝试满足可被消费者接受的许多标准。 These cleansing formulations have attempted to satisfy a number of criteria to be acceptable to consumers. 这些标准包括清洁效力、肤感、对皮肤、毛发和眼粘膜温和以及泡沫丰富。 These standards include cleaning effectiveness, skin feel, skin, hair, eyes and mucous membranes moderate and rich foam. 理想的个人清洁剂应温和地清洁皮肤或毛发,产生很小或不产生刺激,在频繁使用后不使皮肤或毛发过度干燥。 Ideal personal cleansers should gently cleanse the skin or hair, causes little or no irritation, without the skin or hair overly dry after frequent use.

但是,个人清洁产品的传统形式存在清洁效力与提供调理性能相矛盾的固有的问题。 However, there are inherent problems with the cleaning effectiveness of providing conditioning properties contradictory to traditional forms of personal cleansing products. 此问题的一个解决办法为分别使用清洁产品和调理产品。 One solution to this problem is the use of cleaning products respectively and conditioning products. 但是,这通常不方便或不实际,很多消费者愿意使用对皮肤或毛发具有清洁和调理作用的单一产品。 However, this is usually inconvenient or impractical, many consumers are willing to use a single product has a cleaning and conditioning effect on the skin or hair. 在典型的清洁组合物中,由于许多调理剂与表面活性剂不相容,最终形成不理想的非均相混合物,很难配制调理成分。 In a typical cleaning composition, because many conditioners are incompatible with the surfactant, forming undesirable heterogeneous mixture, conditioning ingredients are difficult to formulate. 为得到含有调理成分的均相混合物,并防止调理成分在沉积前损失,通常加入附加成分,如乳化剂、增稠剂和胶凝剂以在表面活性剂混合物中悬浮调理成分。 To obtain a homogeneous mixture containing conditioning ingredients, and to prevent the loss of conditioning ingredients before deposition, additional ingredients are usually added, such as emulsifiers, thickening and gelling agents in suspension conditioned surfactant mixture ingredients. 这样产生了外观上令人满意的均相混合物,但是由于调理剂被乳化而且在清洗中不能有效地释放,通常会引起调理成分较差的沉积。 This produces a homogeneous mixture is satisfactory in appearance, but because conditioning agent is emulsified and not efficiently released during cleaning, often cause poor deposition of conditioning ingredients. 并且,许多调理剂有抑制泡沫生成的缺点。 Also, many conditioning agents have the disadvantage of suppressing foam generation. 因为许多消费者选择可提供丰富、稀奶油似的泡沫的产品,泡沫的抑制为一个难题。 Because many consumers choose to provide a rich, cream-like foam products, foam suppression is a problem.

另外,传统的配方在将水溶性调理剂沉积到皮肤或毛发方面的有效性很差。 Further, the effectiveness of conventional formulations poorly soluble in the deposition of conditioning agents to the skin or hair areas. 我们希望将油溶性调理剂(例如软化剂和脂)和水溶性调理剂(例如湿润剂)都沉积到皮肤上,以最大化其快速和长期的皮肤调理优点。 We hope that the oil soluble conditioning agent (such as softeners and fat) and water soluble conditioning agents (such as wetting agents) are deposited on the skin, in order to maximize its rapid and prolonged skin conditioning benefits. 采用合适的复配技术利用油溶性调理剂固有的疏水特性可将其沉积到皮肤或毛发上。 Suitable complex technology using oil soluble conditioning agent using the inherent hydrophobic character can be deposited onto the skin or hair. 但是,水溶性调理剂与传统的清洁剂的沉积通常是困难的,这是因为水溶性调理剂一般会被漂洗去而只留下疏水性试剂沉积。 However, the conventional water soluble conditioning agent deposition cleaners is often difficult, because the water soluble conditioning agent will generally be rinsed to leave only the hydrophobic agent is deposited. 通过使用多相乳液(例如水包油包水乳液),多次尝试沉积水溶性调理剂。 By using multiple emulsions (e.g. water-in-oil emulsion), water soluble conditioning agent is deposited several attempts. 虽然在理论上是可行的,但这项研究在实践上是很困难的,因为其长期的贮存稳定性和产品的美观特性都较差。 Although theoretically possible, but in practice this research is very difficult because of its long-term storage stability and aesthetic characteristics of the product are poor.

本发明解决了这一难题,表面活性剂和调理剂可以分别直接加到基质上。 The present invention solves this problem, surfactants and conditioning agents may be applied directly to the substrate. 在这种情况下,水溶性调理剂可简单地乳化到油溶性试剂中而被加到基质上。 In this case, the water-soluble conditioning agent may simply be an oil-soluble emulsifying agent to be added to the substrate. 该简单乳液可在基质上保持稳定,可防止水溶性调理剂在清洁过程中被漂洗去,因为水溶性调理剂在乳液中得到了保护。 The simple emulsion is stable on the substrate can be maintained to prevent water soluble conditioning agent is rinsed in the cleaning process, since the water soluble conditioning agent are protected in the emulsion. 其结果是,本发明可有效地将油溶性调理剂和水溶性调理剂沉积到皮肤和毛发上。 As a result, the present invention is effective to oil soluble conditioning agent and a water soluble conditioning agent is deposited onto the skin and hair.

因此,可以看到由于表面活性剂、水溶性调理剂和油溶性调理剂固有的不相容的缺点,传统清洁产品中把表面活性剂与水溶性调理成分和油溶性调理剂成分混合的尝试非常难。 Therefore, attempts can be seen that due to the incompatibility of the inherent disadvantages of surfactant, water soluble conditioning agent and oil soluble conditioning agent, in the conventional cleaning product surfactant component and a water soluble conditioning agent is oil soluble conditioning component is mixed difficult. 显然需要开发出清洁体系,该体系在单一产品中,可提供有效的清洁并可沉积水溶性和油溶性调理剂。 Clearly a need to develop a cleaning system which is in a single product, provides effective cleaning and deposition of conditioning agents and oil-soluble.

由可自由使用的一次性产品提供清洁和调理性能是非常理想的。 Provide cleaning and conditioning properties by the use of disposable products freely is ideal. 由于避免了携带笨重的瓶子、块状物、罐、管子及其它形式的清洁和调理产品,可自由使用的产品十分方便。 By avoiding to carry a bulky bottles, lumps, tanks, pipes and other forms of cleaning and conditioning products, free use of the product is very convenient. 可自由使用产品比使用海绵、毛巾或其它多次使用的清洁用具更卫生,因为这些用具有与重复使用相关的细菌繁殖、难闻气味及其它的不理想的性质。 Free to use product than sponge, towel, or other multiple-use cleaning tools and more hygienic because they have associated with the repeated use of bacteria, unpleasant odors and other undesirable properties.

本发明意外地发现,可以开发一种产品,可在方便、便宜、卫生的一次性个人清洁产品中提供有效的清洁和调理。 The present inventors have surprisingly found, you can develop a product that can be convenient, inexpensive, disposable personal hygiene cleaning products provide effective cleaning and conditioning. 本发明提供的方便是,不需使用单独的清洁和调理产品。 To facilitate the present invention is provided without the use of separate cleansing and conditioning products. 由于本发明为基本上干燥的产品,在使用前润湿,使用十分方便。 Since the present invention is a substantially dry product, before use wetting, easy to use.

本发明涉及一种干燥、一次性的个人清洁产品,适用于清洁和调理皮肤或毛发。 The present invention relates to a dry, disposable personal cleansing products for cleansing and conditioning the skin or hair. 消费者可通过把干燥产品用水润湿进行使用。 Consumers can use the products through the drying moistened with water. 产品由水不溶性基质、表面活性剂和调理乳液组成。 Products from water-insoluble substrate, a surfactant and a conditioning emulsion composition. 不受理论的限制,据信基质可在低表面活性剂含量下加强起泡,加大清洁和剥脱作用,并使水溶性和油溶性调理成分的传递和沉积达到最佳。 Is not limited by theory, it is believed that the substrate enhances foaming agent at low surfactant content, to increase the cleaning action and exfoliation, and delivery and deposition of conditioning oil soluble and water soluble components to achieve the best. 总体来说,本发明提供了一种有效的清洁产品,其中使用低含量的表面活性剂,因而刺激很小,并可提供优良的调理性能。 In general, the present invention provides an effective cleaning product, wherein the surfactant content is low, and thus stimulating small, and can provide excellent conditioning performance. 同时发现这些产品在清洁过程中,各种活性成分可传递到皮肤或毛发上。 These products are also found in the cleaning process, each active ingredient can be transferred to the skin or hair.

因此,本发明的一个目的为提供用于清洁和调理皮肤或毛发的基本上干燥的产品,其中产品与水一同使用。 It is therefore an object of the present invention to provide substantially dry products for cleansing and conditioning the skin or hair wherein the products used in conjunction with water.

本发明的另一个目的是提供能将水溶性调理剂和油溶性调理剂一同输送到皮肤和毛发上的产品。 Another object of the present invention to provide a water soluble conditioning agent, and capable of oil soluble conditioning agent together with products delivered to the skin and hair.

本发明的另一个目的是提供能将水溶性调理剂输送到皮肤和毛发上的产品。 Another object of the present invention to provide a water soluble conditioning agent is capable of transporting the product to the skin and hair.

本发明的另一个目的是提供含有水不溶性基质、表面活性剂和调理乳液的产品。 Another object of the present invention is to provide a water-insoluble matrix containing a surfactant and a conditioning emulsion products.

本发明的另一个目的是提供自由使用的一次性的产品。 Another object of the present invention is to provide a freedom to use disposable products.

本发明的另一个目的是提供对皮肤或毛发温和的产品。 Another object of the present invention is to provide a product for the skin or hair gently.

本发明的另一个目的是一种提供产品,该产品在清洁和调理过程中,可将活性成分传递到皮肤或毛发上。 Another object of the present invention to provide a product which in the process of cleaning and conditioning, the active ingredient may be transferred to the skin or hair.

本发明的另一个目的是提供清洁和调理皮肤或毛发的方法。 Another object of the present invention to provide a cleansing and conditioning the skin or hair methods.

本发明的另一个目的是提供本发明产品的制造方法。 Another object of the present invention to provide a method of manufacturing a product according to the present invention.

本发明的这些目的和其它目的通过以下叙述,将会很清楚。 These and other objects of the present invention by the following description, it will be apparent.

发明概要本发明介绍了一种可自由使用的、一次性的个人护理清洁和调理产品,含有:(A)水不溶性基质,(B)起泡型表面活性剂,和(C)调理乳液,其中所述的产品基本上是干燥的。 SUMMARY The present invention describes a freely available, disposable personal care cleansing and conditioning product comprising: (A) a water insoluble substrate, (B) a lathering surfactant, and (C) conditioning emulsion, wherein the product is substantially dry.

在另外的实施方案中,本发明介绍了可自由使用的一次性个人清洁和调理产品,含有:(A)水不溶性基质,和(B)起泡型表面活性剂,和(C)调理乳液,它包括:(i)包含水溶性调理剂的内相,和(ii)包含油溶性试剂的外相,其中所述起泡型表面活性剂和所述调理乳液分别或同时加入或浸渍入所述的水不溶性基质中,其中所述产品基本上是干燥的。 In a further embodiment, the present invention describes a disposable personal cleansing and conditioning products freely available, comprising: (A) water-insoluble substrate, and (B) a lathering surfactant, and (C) conditioning emulsion, which comprises: (i) an internal phase comprising water soluble conditioning agent, and (ii) the external phase comprising an oil soluble agent, wherein said lathering surfactant and the conditioning emulsion separately or simultaneously added or impregnated into the a water-insoluble matrix, wherein said product is substantially dry.

在另一实施方案中,本发明涉及一次性的个人护理清洁及调理产品的制备方法,该方法包含以下步骤:分别或同时将下列物质加入或浸渍入水不溶性基质中:(A)起泡型表面活性剂,和(B)调理乳液,包含(i)包含水溶性调理剂的内相,和(ii)包含油溶性试剂的外相,其中所述产品基本上是干燥的。 In another embodiment, the present invention relates to disposable personal care cleansing and conditioning product is prepared, the method comprising the steps of: separately or simultaneously added the following materials or impregnated into the water insoluble substrate in: (A) a lathering surface active agent, and (B) conditioning emulsion, contained therein (i) a water soluble conditioning agent phase, and (ii) the external phase comprising an oil soluble agent, wherein said product is substantially dry.

在另一实施方案中,本发明进一步包含能形成所述的内外相乳液的乳化剂。 In another embodiment, the present invention further comprises an emulsifier capable of forming the inner and outer phases of the emulsion.

在另一实施方案中,本发明涉及用所述个人清洁产品清洁和调理皮肤或毛发的方法。 In another embodiment, the present invention relates to a method of using the personal cleansing products cleansing and conditioning the skin or hair.

在另一实施方案中,本发明涉及将调理剂沉积到皮肤和毛发上的方法。 In another embodiment, the present invention relates to a method of deposition of conditioning agents to the hair and skin.

除非另有说明,本发明中所有的百分比和比率都是重量百分比和比率,且都是在25℃条件下测量的。 Unless otherwise indicated, all percentages and ratios in the present invention, percentages and ratios are by weight, and is measured at 25 ℃ of. 本发明可包括、由或基本上由这里所述的必需组分以及非必选成分和组分所组成。 The present invention may comprise, consist or consist essentially of the essential components described herein, and non-mandatory ingredients and components composed.

发明详述本发明的个人清洁产品对清洁皮肤或毛发非常有效,可使水溶性调理剂有效地沉积。 DETAILED DESCRIPTION personal cleansing products of the present invention is very effective for cleansing the skin or hair, can effectively deposit water soluble conditioning agents. 本发明产品对清洁以及沉积水溶性调理剂和油溶性调理剂也是非常高效的。 The present invention is a water-soluble product for cleaning and depositing conditioning agents and oil soluble conditioning agent is very efficient. 这些产品还可含有其它可沉积到皮肤或毛发上的活性成分。 These products may also contain other active ingredients deposited on the skin or hair.

不受理论的限制,据信基质非常有助于泡沫的生成、调理剂和其它任何活性成分的沉积。 Is not limited by theory, it is believed very useful matrix deposition foam generation, conditioning agents and any other active ingredients. 据信起泡的增强是基质表面作用的结果。 It is believed to enhance foaming is a result of the surface action of the substrate. 这样,可以使用更温和的十分少量的表面活性剂。 This allows the use of very small amounts of milder surfactants. 据信,表面活性剂所需用量的减少与表面活性剂对皮肤或毛发的干燥作用的减轻有关。 It is desired signal, the amount of surfactant is reduced with a surfactant to reduce the drying effect of the skin or hair concerned. 此外,用量减少的表面活性剂大大降低了表面活性剂对调理剂沉积的抑制作用(如乳化或通过表面活性剂直接除去)。 In addition, reducing the amount of surfactant significantly reduces the inhibitory effect of surfactants on the deposition of conditioning agents (e.g., emulsification or direct removal by the surfactants).

不受理论的限制,基质除了可增强调理乳液中的调理剂的沉积外,还可增强活性成分和调理剂的沉积。 Without being bound by theory, the substrate enhances deposition of conditioning in addition to conditioning agent in the emulsion, but also enhanced deposition of conditioning agents and active ingredients. 由于本发明产品为干燥的形式,不需要其它乳化剂使产品均匀,而乳化剂会抑制调理剂和活性成分的沉积。 Due to the present invention is in a dry form, no further emulsifier products made uniform, while the emulsifier can inhibit deposition of conditioning agents and active ingredients. 此外,由于皮肤调理剂和活性成分干燥地涂在基质上或浸渍在基质中,可以通过润湿的产品与皮肤的表面接触,把调理剂和活性成分直接传递到皮肤或毛发上。 Furthermore, because the skin conditioners and active ingredients are applied on the substrate and dried or impregnated in the matrix, can be moistened by contact with the skin surface of the product, the conditioning agents and active ingredients transferred directly to the skin or hair.

最后,基质还可增强清洁力。 Finally, the matrix may also enhance the cleaning power. 基质的每一面可有不同的质地,如粗糙面和光滑面。 Each side of the matrix can have different textures, such as a rough surface and a smooth surface. 基质可用作有效的起泡和剥脱用具。 Matrix used as an effective foaming and stripping equipment. 通过与皮肤或毛发的物理接触,基质非常有助于清洁并除去污垢、化妆品、死皮和其它碎屑。 By physical contact with the skin or hair, the substrate is cleaned and help remove dirt, makeup, dead skin, and other debris.

“起泡型表面活性剂”是指一种表面活性剂,当与水混合并机械搅动时,可产生泡沫。 "Lathering surfactant" is meant a surface active agent, when mixed with water and mechanically agitated, the foam may be generated. 优选地,这些表面活性剂应为温和的,意思是这些表面活性剂可提供足够的清洁或去垢性能,但不使皮肤或毛发过度干燥,还要符合上述的起泡标准。 Preferably, these surfactants should be mild, which means that these surfactants provide sufficient cleansing or detergent properties, but do not overly dry the skin or hair, but also meet the lathering criteria described above.

此处使用的术语“可自由使用”或“一次性使用”,在一般意义上是指在使用一次后即可处理或丢弃的产品。 Herein, the term "free to use" or "single use" in a generic sense refers to a single use products or discarded after processing.

此处使用的术语“水活化”,是指本发明产品以干燥形式提供给消费者,需要用水润湿后使用。 As used herein, the term "water-activated," refers to the product of the present invention is provided to the consumer in dry form, moistened with water after use requires. 已发现这些产品在与水接触并进一步搅动后,可产生泡沫或被“活化”。 These products have been found upon contact with water and further agitation, the foam may be generated or "activated."

此处使用的术语“基本上干燥”,是指产品基本上不含水,而且一般触感为干燥的。 As used herein, the term "substantially dry", means that the product is substantially free of water and generally is touch dry. 本发明的产品含有小于约15%重量的水,优选地小于约7.5%重量的水,更优选地小于约3%重量的水,在干燥环境,如低湿度下进行测定。 The product of the present invention contain less than about 15% by weight water, preferably less than about 7.5% by weight of water, more preferably less than about 3% by weight of water was measured in a dry environment, such as low humidity. 本领域具有一般技能的人会理解,在本发明中的产品的水含量会随环境相对湿度的不同而不同。 The present having ordinary skill in the art will appreciate, the water content of the product in the present invention the relative humidity will vary with the environment.

此处使用的术语“调理乳液”指的是在含有水溶性调理剂的内相外包围着含有油溶性试剂的外相的组合。 Herein, the term "conditioning emulsion" refers to a combination of the external phase in the outer phase containing a water soluble conditioning agent comprising an oil soluble agent around. 在优选的实施方案中,调理乳液可进一步包含乳化剂。 In preferred embodiments, the conditioning emulsion further comprises an emulsifier.

此处使用的术语“温和”,与起泡型表面活性剂和本发明的产品有关,是指本发明的产品对皮肤具有可与温和的烷基甘油醚磺酸盐(AGS)表面活性剂基合成块皂相比的温和性。 The term "moderate", and the product lathering surfactants and the present invention is related to the present invention refers to a product having a skin with a mild surfactant-based alkyl glyceryl ether sulfonates (AGS) syndet bar mildness compared. 测定含有表面活性剂的产品的温和性的方法,或相反地测定刺激性的方法,是基于皮肤阻挡层破坏试验。 The method of measuring mildness surfactant-containing product, or method of determination irritating conversely, is based on skin barrier destruction test. 本试验中,表面活性剂越温和,皮肤阻挡层破坏的越少。 In this test, the milder the surfactant, the skin barrier is damaged less. 皮肤阻挡层的破坏是由通过皮肤表皮从试验溶液进入到扩散室中的生理缓冲剂中的放射性标记(氚标记)水(3H-H2O)的相对量进行测定的。 Skin barrier destruction is entered from the test solution through the skin epidermis into the diffusion chamber radiolabel in physiological buffer (tritiated) the relative amounts of water (3H-H2O) were measured. 该试验在TJFranz的《皮肤病学研究》(J.Invest.Dermatol.)1975年,64卷,(190-195页)和1987年6月16日授权Small等人的美国专利4,673,525号中有描述,在此整体引用作为参考。 The test is described in TJFranz of "Investigative Dermatology" (J.Invest.Dermatol.) 1975 years 64, (pages 190-195), and June 16, 1987 authorizing the Small et al., US Patent No. 4,673,525, , incorporated by reference herein in its entirety. 也可使用本领域有技能的人熟知的测定表面活性剂温和性的其它试验方法。 Other test method for determining surfactant mildness can also be used in the art skilled man well known.

本发明的个人护理产品含有以下必需成分:水不溶性基质;起泡型表面活性剂;和调理乳液。 The personal care products of the present invention contains the following essential ingredients: a water-insoluble substrate; lathering surfactant; and a conditioning emulsion. 其它的活性成分可以包含在基质上或乳液中。 Other active ingredients may be included in the matrix or emulsion. 另外在以下调理乳液部分描述的调理剂可以与调理乳液分别加入基质上。 Further conditioning agents described below in the conditioning emulsion conditioning emulsion can be added portion on the substrate, respectively. 另外,优选的方法是将表面活性剂、调理乳液和其它活性成分分别加入基质中。 Further, the preferred method is a surfactant, and a conditioning emulsion further active ingredients are added to the matrix.

水不溶性基质本发明的产品含有水不溶性基质。 Water-insoluble matrix according to the present invention contains a water-insoluble matrix product. “水不溶性”,是指基质浸渍在水中后,不溶解也不易破碎。 "Water-insoluble" refers to a substrate immersed in water and does not dissolve too easily broken. 水不溶性基质为把本发明的起泡型表面活性剂和调理成分传递到待清洁和调理的皮肤或毛发上的用具。 The water-insoluble matrix is ​​the transfer of the invention foaming surfactant and the conditioning component to the appliance to be a cleansing and conditioning the skin or hair. 不受理论的限制,据信通过机械搅动,基质可提供泡沫生成作用,而且有助于调理成分的沉积。 Is not limited by theory, it is believed that by mechanical agitation, the matrix may provide a foam generating action, and contributes to the deposition of the conditioning ingredients.

有许多材料可以用作基质。 There are many materials may be used as a matrix. 以下非限制性特点是期望的:(i)使用时足够的湿态强度,(ii)足够的磨损度,(iii)足够的膨松和孔隙,(iv)足够的厚度,和(v)适宜的尺寸。 The following non-limiting characteristics are desirable: sufficient wet strength (i) is used, (ii) a sufficient degree of wear, (iii) sufficient loft and porosity, (iv) sufficient thickness, and (v) appropriate size of.

符合上述标准的适宜的水不溶性基质的非限制性例子有无纺基质、织物基质、水喷交缠基质、气喷交缠基质、天然海绵、合成海绵、高分子网等等。 Non-limiting examples of suitable water meeting the above criteria insoluble matrix of non-woven substrates, textile substrates, water jet entangled substrates, air jet entangled substrates, natural sponges, synthetic sponges, and the like polymer network. 由于无纺基质经济且易于从许多原料中得到,优选实施方案中使用无纺基质。 Since the nonwoven substrate from a number of economic and readily available starting materials, preferred embodiment, a nonwoven matrix. 无纺的意思是该层由纤维构成,纤维不是编织成织物,而是形成一薄片、垫或衬垫层。 Means that the nonwoven layer is composed of fibers, the fibers are not woven into a fabric but rather form a sheet, mat, or pad layer. 纤维可以是不规则的(即不规则地排列),也可以经过梳理(即梳理使其在一主要方向上取向)。 The fibers may be of irregular (i.e. irregularly arranged), may be carded (i.e. combed so oriented in a main direction). 此外无纺基质可由不规则纤维和梳理纤维的组合层构成。 Further matrix may be a combination of layers of nonwoven carded fibers and irregular configuration.

无纺基质可由包括天然和合成的许多材料构成。 The nonwoven substrate may be formed of many materials include natural and synthetic configuration. 天然的意思是材料来源于植物、动物、昆虫或植物、动物和昆虫的副产品。 It means natural byproduct material is derived from plants, animals, insects or plants, animals, and insects. 合成的意思是材料主要来源于各种人造材料或经过进一步加工的天然材料。 Synthesis means are imported from various man-made materials or from natural materials further processed. 传统的基础起始材料通常为纤维网,其中含有任何的普通的合成或天然纺织纤维,或其混合物。 The conventional base starting material is usually a fibrous web, which contain any common synthetic or natural textile fibers, or mixtures thereof.

本发明中适用的天然材料的非限制性例子有丝纤维、角蛋白纤维和纤维素纤维。 Non-limiting examples of the present invention, suitable natural materials are silk fibers, keratin fibers and cellulosic fibers. 角蛋白纤维的非限制性例子有选自于羊毛纤维、驼毛纤维等等的纤维。 Non-limiting examples of keratin fibers selected from wool fibers, camel hair fibers, and the like fibers. 纤维素纤维的非限制性例子有选自于木浆纤维、棉纤维、大麻纤维、黄麻纤维、亚麻纤维及其混合物的纤维。 Non-limiting examples of cellulosic fibers are fibers selected from wood pulp fibers, cotton fibers, hemp fibers, jute fibers, flax fibers, and mixtures thereof.

本发明中适用的合成材料的非限制性例子有选自于醋酸纤维、聚丙烯酸系纤维、纤维素酯纤维、改良聚丙烯酸系纤维、聚酰胺纤维、聚酯纤维、聚烯烃纤维、聚乙烯醇纤维、人造丝纤维、聚氨酯泡沫及其混合物的纤维。 Non-limiting examples of synthetic materials useful in the invention are selected from cellulose acetate, polyacrylic fibers, cellulose ester fibers, modified polyacrylic fibers, polyamide fibers, polyester fibers, polyolefin fibers, polyvinyl alcohol fibers, rayon fibers, polyurethane foam and fiber mixture. 这些合成材料的例子有丙烯酸类,如阿克利纶、克列丝纶和丙烯腈基纤维-奥纶;纤维素酯纤维,如纤维素醋酸酯、阿尼尔和阿西尔;聚酰胺,如尼龙(如尼龙6、尼龙66、尼龙610等等);聚酯,如福特勒尔、科代尔和聚对苯二甲酸乙二酯纤维-涤纶;聚烯烃,如聚丙烯、聚乙烯;聚醋酸乙烯酯纤维;聚氨酯泡沫及其混合物。 Examples of these synthetic materials include acrylics such as acrilan, acrylonitrile-based fibers and nylon Ke Liesi - orlon; cellulose ester fibers such as cellulose acetate, and Anil Asir; polyamides, such as nylon (such as nylon 6, nylon 66, nylon 610, etc.); polyesters, such as Ford Harrell, Section Dyer and polyethylene terephthalate fibers - polyester; polyolefins, such as polypropylene, polyethylene; vinyl acetate fiber; polyurethane foam, and mixtures thereof. 由此制备的这些和其它适宜的纤维和无纺材料在Riedel的“无纺结合方法和材料”,《无纺世界》(NonwovenWorld)(1987年);《美洲百科全书》(The EncyclopediaAmericana)1984年第11卷(147-153页)和第26卷(566-581页);1990年1月2日授权Thaman等人的美国专利4,891,227号和美国专利4,891,228号中有总体描述,在此整体引用作为参考。 The thus prepared these and other suitable fibers and the nonwoven materials in Riedel "Nonwoven bonding methods and materials", "Nonwoven World" (NonwovenWorld) (1987); the "American Encyclopedia" (The EncyclopediaAmericana) 1984 years volume 11 (pages 147-153) and volume 26 (pages 566-581); January 2, 1990 authorized Thaman et al., US Patent No. 4,891,228 and US Patent No. 4,891,227 has a general description, reference herein in its entirety as reference.

由天然材料制得的无纺基质,通常是由纤维的悬浮液在精细金属丝网板上制成的网和薄片构成。 Nonwoven matrix made of natural materials, usually composed of a fiber mesh sheet and a suspension of the fine mesh plate made of metal. 见CAHampel等人的《化学百科全书》1973年第3版(793-795页);《美洲百科全书》1984年第21卷(376-383页)和GASmook的《纸浆和纸技术手册》,纸浆和纸工业技术协会(1986年),在此整体引用作为参考。 See CAHampel et al, "Encyclopedia of Chemistry," 3rd edition, 1973 (pages 793-795); "American Encyclopedia", Vol. 21, 1984 (pages 376-383) and GASmook of "Pulp and Paper Technical Manual", pulp and paper industry technical Association (1986), incorporated by reference herein in its entirety.

由适用于本发明的天然材料制得的基质可从许多工业来源获得。 May be useful in the present invention is obtained from a natural material obtained from many industrial sources matrix. 此处适用的适宜的工业纸层的非限制性例子有AirtexR,压花气流成网纤维素层,基重约为71gsy,可从James River(GreenBay,WI)获得;WalkisoftR,压花气流成网纤维素,基重约为75gsy,可从Walkisoft USA(Mount Holly,NC)获得。 Non-limiting examples of suitable industrial paper layers useful herein are AirtexR, embossed airlaid cellulosic layer, a basis weight of about 71gsy, available from James River (GreenBay, WI); WalkisoftR, embossed airlaid cellulose, basis weight of about 75gsy, available from Walkisoft USA (Mount Holly, NC).

制备无纺基质的方法在本领域是众所周知的。 Method of making nonwoven substrates are well known in the art. 一般地,这些无纺基质可以通过气流成网、水流成网、熔体喷出、同时成型、纺粘法或梳理方法制备,其中纤维或长丝首先从长股切成需要的长度,通过水流或气流,然后沉积在网板上,充满纤维的气流或水流通过此网板。 Generally, these nonwoven substrates can be made by air laying, water-laying, melt discharge, prepared while forming, spunbonding, or carding process, wherein the fibers or filaments are first cut to desired length long stocks, water flow or gas stream, and then deposited on the screen plate, the fiber filled with air or water through this screen. 不管其生产方法或组成,最终的层要经历至少几种粘合操作中的一种,以把纤维个体固定在一起,形成自持网。 Regardless of which method of production or composition, the final layer to be subjected to at least one of several bonding operation, to the individual fibers together to form a self-sustaining web. 本发明中,无纺层可以通过各种方法制备,这些方法有水喷交缠、热粘合以及这些方法的组合。 In the present invention, the nonwoven layer can be prepared by various methods, these methods have a water jet entangled, heat-bonding, and combinations of these methods. 此外,本发明的基质可由单层或多层构成。 Further, the matrix may be single or multilayer configuration of the present invention. 另外,多层基质可包括薄膜和其它非纤维材料。 Further, the multilayer substrate can include films and other nonfibrous materials.

由本发明中适用的合成材料制得的无纺基质也可从许多工业来源获得。 Suitable for the present invention are synthetic materials obtained nonwoven substrates may also be obtained from many industrial sources. 此处适用的适宜无纺层材料的非限制性例子有HEF 40-047,含有约50%人造丝和50%聚酯的带孔水喷交缠材料,基重约为43克每平方码(gsy),可从Veratec,Inc.(Walpole,MA)获得;HEF 140-102,含有约50%人造丝和50%聚酯的带孔水喷交缠材料,基重约为56gsy,可从Veratec,Inc.(Walpole,MA)获得;NovonetR149-616,含有约100%聚丙烯的热粘合网格纹材料,基重约为50gsy,可从Veratec,Inc.(Walpole,MA)获得;NovonetR149-801,含有约69%人造丝、约25%聚丙烯和约6%棉的热粘合网格纹材料,基重约为75gsy,可从Veratec,Inc.(Walpole,MA)获得;NovonetR149-191,含有约69%人造丝、约25%聚丙烯和约6%棉的热粘合网格纹材料,基重约为100gsy,可从Veratec,Inc.(Walpole,MA)获得;HEF NubtexR149-801,含有约100%聚酯的小块带孔水喷交缠材料,基重约为70gsy,可从Veratec,Inc.(Walpole,MA)获得;KeybakR951V,含有约75 Nonlimiting examples of suitable nonwoven layer materials suitable herein have HEF 40-047, an apertured water containing about 50% rayon and 50% polyester jet entangled material, a basis weight of about 43 grams per square yard ( GSY), available from Veratec, Inc (Walpole, MA);. HEF 140-102, an apertured water containing about 50% rayon and 50% polyester jet entangled material, basis weight of about 56gsy, available from Veratec ., Inc (Walpole, MA) is obtained; NovonetR149-616, thermal bonding pattern mesh material containing about 100% polypropylene, basis weight of about 50gsy, available from Veratec, Inc (Walpole, MA) is obtained;. NovonetR149- 801, containing about 69% rayon, about 25% polypropylene, and about 6% cotton mesh pattern of thermal bonding materials, basis weight of about 75gsy, available from Veratec, Inc (Walpole, MA) is obtained;. NovonetR149-191, containing about 69% rayon, about 25% polypropylene, and about 6% cotton mesh pattern of thermal bonding materials, basis weight of about 100gsy, available from Veratec, Inc (Walpole, MA) is obtained;. HEF NubtexR149-801, comprising to about 100% polyester of small water jet entangled apertured material, basis weight of about 70gsy, available from Veratec, Inc (Walpole, MA);. KeybakR951V, containing about 75 %人造丝、约25%丙烯酸类纤维的干燥成型带孔材料,基重约为43gsy,可从Chicopee(New Brunswick,NJ)获得;KeybakR1368,含有约75%人造丝、约25%聚酯的带孔材料,基重约为39gsy,可从Chicopee(New Brunswick,NJ)获得;DuralaceR1236,含有约100%人造丝的带孔水喷交缠材料,基重为约40gsy到约115gsy,可从Chicopee(New Brunswick,NJ)获得;DuralaceR5904,含有约100%聚酯的带孔水喷交缠材料,基重为约40gsy到约115gsy,可从Chicopee(New Brunswick,NJ)获得;Sontaro 8868,含有约50%纤维素和约50%聚酯的水喷交缠材料,基重约为60gsy,可从Dupont Chemical Corp.获得。 % Rayon, dried molding material is perforated from about 25% acrylic fibers, basis weight of about 43gsy, available from Chicopee (New Brunswick, NJ); KeybakR1368, containing about 75% rayon, about 25% polyester with porous material, basis weight of about 39gsy, available from Chicopee (New Brunswick, NJ); DuralaceR1236, perforated water containing about 100% rayon jet entangled material, a basis weight of from about to about 40gsy 115gsy, available from Chicopee ( new Brunswick, NJ) is obtained; DuralaceR5904, perforated water containing about 100% polyester jet entangled material, a basis weight of from about to about 40gsy 115gsy, available from Chicopee (new Brunswick, NJ); Sontaro 8868, containing about 50 % cellulose and about 50% water jet entangled polyester material, basis weight of about 60gsy, available from Dupont Chemical Corp..

另外,水不溶性基质可以是1996年3月27日公开的欧洲专利EP702550 A1号中叙述的高分子网海绵,此处整体引用作为参考。 In addition, water-insoluble matrix may be a European patent March 27, 1996 disclosure described in No. EP702550 A1 polymer network sponge, the whole incorporated herein by reference. 高分子海绵中含有多层挤出管状网,管状网由高弹性聚合物,如烯烃单体与多羧酸聚酰胺的加聚物制备。 A multilayered polymer sponge extruded tubular mesh, as prepared by the tubular mesh olefin monomer elastomeric polymer with a polycarboxylic acid polyamide oligomer added. 尽管这些高分子海绵设计与液体清洁剂一同使用,这些海绵可以用作本发明的水不溶性基质。 Although these high molecular sponge with liquid detergent and design, sponges can be used as the water-insoluble matrix of the present invention.

基质可以制成各种形状,有平坦衬垫、厚衬垫、薄片、球形用具、不规则形状用具,以表面积代表的尺寸为约1平方英寸到约数百平方英寸。 Matrix can be formed into various shapes, a flat pads, thick pads, flake, spherical appliances, utensils irregular shape, the surface area represented by a size of about 1 square inch to about hundreds of square inches. 精确尺寸将视使用需要和产品特点而定。 The exact size will depend on the need and use of product characteristics may be. 特别方便的有方形、圆形、矩形或椭圆形衬垫,表面积为约1平方英寸到约144平方英寸,优选地约10平方英寸到约120平方英寸,更优选地约30平方英寸到约80平方英寸,厚度为约1密耳到约500密耳,优选地约5密耳到约250密耳,更优选地约10密耳到约100密耳。 A particularly convenient square, round, oval or rectangular pad, a surface area of ​​from about 1 in2 to about 144 in2, preferably from about 10 in2 to about 120 in2, more preferably from about 30 in2 to about 80 square inches, a thickness of about 1 mil to about 500 mils, preferably from about 5 mils to about 250 mils, more preferably from about 10 mils to about 100 mils.

本发明的水不溶性基质可包含两层或多层,每层具有不同的质地和磨损性。 Water-insoluble matrix of the present invention may comprise two or more layers, each having different textures and abrasiveness. 质地的不同是由于使用不同组合的材料或由于使用不同的生产方法,或二者兼有。 Different texture because of the use of different combinations of materials or from the use of different production methods, or both. 双重质地的基质可以提供的优点为,有更具研磨作用的一面,用于剥脱作用;还有更柔软、能吸收的一面,用于温和清洁。 The advantages of dual texture substrate can be provided for, there is a more abrasive side for exfoliation effect; there are even more flexible, able to absorb side for gentle cleansing. 此外,基质的各别层可以制成有不同颜色的面,有助于使用者进一步区分不同表面。 In addition, the matrix layer may be made of respective different colors of the surface, helps the user to further distinguish different surfaces.

起泡型表面活性剂本发明的产品一般含有水不溶性基质重量的约0.5%到约40%,优选地约0.75%到约20%,更优选地约1%到约10%的起泡型表面活性剂。 Product lathering surfactant of the present invention generally contain from about 0.5% by weight of water insoluble matrix to about 40%, preferably from about 0.75% to about 20%, more preferably from about 1% to about 10% lathering surfactant active agent.

起泡型表面活性剂是指一种表面活性剂,当与水混合并机械搅动时,可产生泡沫。 Lathering surfactant is meant a surfactant, when combined with water and mechanically agitated, the foam may be generated. 优选地,这些表面活性剂或表面活性剂组合物应为温和的,意思是这些表面活性剂可提供足够的清洁或去垢性能,但不使皮肤或毛发过度干燥,还要符合上述的起泡标准。 Preferably, these surfactants or surfactant compositions should be mild, which means that these surfactants provide sufficient cleansing or detergent properties, but do not overly dry the skin or hair, but also to meet the above lathering standard.

许多起泡型表面活性剂适用于此处,有选自于阴离子起泡型表面活性剂、非离子起泡型表面活性剂、两性起泡型表面活性剂及其混合物的起泡型表面活性剂。 Many lathering surfactants suitable for use herein, selected from anionic lathering surfactants, nonionic lathering surface lathering surfactants, amphoteric lathering surfactants, and mixtures of the active agent . 通常,起泡型表面活性剂不会强烈干扰调理剂的沉积,例如这些表面活性剂基本上是水溶性的通常其HLB值大于10。 Generally, the lathering surfactants do not strongly interfere with deposition of the conditioning agents, for example, these surfactants are substantially water soluble HLB value typically it is greater than 10. 如果阳离子表面活性剂不对必需的起泡型表面活性剂的整体起泡性质产生负面影响,也可用作非必需成分。 If the overall foaming properties lathering surfactant is a cationic surfactant does not adversely affect the essential, non-essential ingredients may also be used.

阴离子起泡型表面活性剂用于本发明组合物中的阴离子起泡型表面活性剂的非限制性实例公开于McCutcheon的洗涤剂与乳化剂,北美版(1986),AlluredPublishing Corporation出版;和McCutcheon的功能物质,北美版(1992);两文献都全部引入作为参考。 Anionic lathering surfactants for use in non-limiting examples of anionic lathering surfactant compositions of the present invention are disclosed in McCutcheon's Detergents and Emulsifiers, North American Edition (1986), AlluredPublishing Corporation publication; and McCutcheon's, functional materials, North American Edition (1992); two documents are hereby incorporated by reference.

各种阴离子起泡型表面活性剂都适用于本发明。 Various anionic lathering surfactants are useful in the present invention. 阴离子起泡型表面活性剂的非限制性实例包括肌氨酸盐、硫酸盐、羟乙磺酸盐、牛磺酸盐、磷酸盐、乳酸盐、谷氨酸盐及其混合物。 Nonlimiting examples of anionic lathering surfactants include sarcosinates, sulfates, isethionates, taurates, phosphates, lactylates, glutamates and mixtures thereof. 在羟乙磺酸盐中,优选烷酰基羟乙磺酸盐,在硫酸盐中,优选烷基硫酸盐与烷基醚硫酸盐。 In the isethionates, alkanoyl isethionates preferred, and amongst the sulfates, preferably alkyl sulfates and alkyl ether sulfates. 一般烷酰基羟乙磺酸盐可以式RCO-OCH2CH2SO3M表示,其中R是约10-约30个碳原子的烷基或链烯基,M是水溶性阳离子,如铵、钠、钾及三乙醇胺。 Alkanoyl isethionates typically be represented by the formula RCO-OCH2CH2SO3M, wherein R is from about 10 to about 30 carbon atoms or an alkenyl group, M is a water-soluble cation such as ammonium, sodium, potassium and triethanolamine. 这些羟乙磺酸盐的非限制性实例包括选自椰油酰基羟乙磺酸铵、椰油酰基羟乙磺酸钠、月桂酰基羟乙磺酸钠及它们的混合物的烷酰基羟乙磺酸盐。 Nonlimiting examples of these isethionates include those selected from ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate, and mixtures thereof alkanoyl isethionic salt.

烷基硫酸盐和烷基醚硫酸盐通常可用式ROSO3M和RO(C2H4O)XSO3M表示,式中R是约10-约30个碳原子的烷基或链烯基,x是约1-约10、M是水溶性阳离子如铵、钠、钾及三乙醇胺。 Alkyl sulfates and alkyl ether sulfates generally be of the formula ROSO3M and RO (C2H4O) XSO3M represented, wherein R is from about 10 to about 30 carbon atoms or an alkenyl group, x is from about 1 to about 10, M is a water-soluble cation such as ammonium, sodium, potassium and triethanolamine. 另一类适用的阴离子表面活性剂是硫酸与有机物反应产物的水溶性盐,其通式为:R1-SO3-M式中R1是选自含约8-约24,优选约10-约16个碳原子直链或支链的饱和脂族烃基,M是阳离子。 Another suitable class of anionic surfactants are water-soluble salts of organic sulfuric acid reaction products of the general formula: R1-SO3-M wherein R1 is selected from the group containing from about 8 to about 24, preferably from about 10 to about 16 carbon atoms, straight-chain or branched-chain saturated aliphatic hydrocarbon group, M is a cation. 其它合成的阴离子表面活性剂还包括称为琥珀酰胺酸盐、含约12-约24个碳原子的烯烃磺酸盐及b-烷氧基链烷磺酸盐的一类。 Other synthetic anionic surfactants also include those known as succinamates, a class of about 12 to about 24 carbon atoms and olefin sulfonates b- alkyloxy alkane sulfonates. 这类物质的实例有月桂基硫酸钠和月桂基硫酸铵。 Examples of such materials are sodium lauryl sulfate and ammonium lauryl sulfate.

适用于本发明的其它阴离子物质是通常含约8-约24个碳原子,优选约10-约20个碳原子的脂肪酸皂(即碱金属盐,如钠盐或钾盐)。 Other anionic materials suitable for the present invention generally contain from about 8 to about 24 carbon atoms, a fatty acid soap is preferably from about 10 to about 20 carbon atoms (i.e. alkali metal salts, such as sodium or potassium salts). 制皂用脂肪酸可从天然来源如从植物或动物中取得的甘油酯(如棕榈油、椰子油、大豆油、蓖麻油、动物脂、猪脂等)中获得。 Esters such as soap may be obtained from natural sources from plants or animals is obtained with a fatty acid (e.g. palm oil, coconut oil, soybean oil, castor oil, tallow, lard, etc.). 脂肪酸也可由合成方法制得。 Fatty acids can also be prepared by synthetic methods. 上面引用的美国专利4557853已对皂类作了较详细的说明。 The above-cited US Patent 4,557,853 has made a more detailed description of the soaps.

其它阴离子物质包括磷酸盐,如单烷基、二烷基和三烷基磷酸盐。 Other anionic materials include phosphates such as monoalkyl, dialkyl and trialkyl phosphates.

其它阴离子物质包括对应于式RCON(CH3)CH2CH2CO2M的链烷酰基肌氨酸盐,其中R是约10-约20个碳原子的烷基或链烯基,M是水溶性阳离子,如铵、钠、钾和烷醇胺(如三乙醇胺),优选的实例是月桂酰基肌氨酸钠、椰油酰基肌氨酸钠和月桂酰基肌氨酸铵和肉豆蔻酰肌氨酸钠。 Other anionic materials include corresponding to the formula RCON (CH3) CH2CH2CO2M alkanoyl sarcosinates, wherein R is from about 10 to about 20 carbon atoms or an alkenyl group, M is a water-soluble cation such as ammonium, sodium , potassium and alkanolamine (e.g., triethanolamine), preferred examples are sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, and ammonium lauroyl sarcosinate and sodium myristoyl sarcosinate. 肌氨酸的TEA盐也是适用的。 TEA salt of sarcosine is also applicable.

也可以采用基于牛磺酸,又称做2-氨基乙烷磺酸,的牛磺酸盐。 Taurine may also be employed, also known as 2- aminoethanesulfonic acid do, based taurate. 尤其适用的是包含C8-C16的牛磺酸盐。 Especially useful are taurates comprising the C8-C16. 牛磺酸盐的实例包括N-烷基牛磺酸类化合物,例如按照US2,658,072的方法,通过十二烷基胺与羟乙磺酸钠反应制备,该专利全部引入本文供参考。 Examples of taurates include N- alkyl taurine compound, for example according to the method of US2,658,072, prepared by reacting dodecylamine with sodium isethionate, which patent is fully incorporated herein by reference. 其它非限制性实例包括月桂酰甲基牛磺酸、肉豆蔻酰甲基牛磺酸和椰油酰甲基牛磺酸的铵、钠、钾和烷醇胺(例如三乙醇胺)盐。 Other non-limiting examples include lauroyl methyl taurate, myristoyl methyl taurate, and cocoyl methyl taurine ammonium, sodium, potassium and alkanolamine (e.g., triethanolamine) salts.

乳酸盐也可在此适用,尤其是那些碳链长度为C8-C16的。 Lactate may also be suitable for use herein, particularly those of carbon chain length of C8-C16. 其非限制性实例包括月桂酰乳酸、椰油酰乳酸、月桂酰乳酸和己酰乳酸的铵、钠、钾和烷醇胺(例如三乙醇胺)盐。 Non-limiting examples include lauroyl lactylate, cocoyl lactylate, lauroyl lactylate, and caproyl lactic acid ammonium, sodium, potassium and alkanolamine (e.g., triethanolamine) salts.

也可在此适用的阴离子表面活性剂是谷氨酸盐,尤其是那些碳链长度为C8-C16的。 Herein may be suitable anionic surfactants are glutamates, especially those with a carbon chain length of C8-C16. 谷氨酸盐的非限制性实例包括月桂酰谷氨酸、肉豆蔻酰谷氨酸和椰油酰谷氨酸的铵、钠、钾和烷醇胺(例如三乙醇胺)盐。 Non-limiting examples of glutamates include lauroyl glutamate, myristoyl glutamate, and cocoyl glutamate, ammonium, sodium, potassium and alkanolamine (e.g., triethanolamine) salts.

这里优选的阴离子起泡型表面活性剂的非限制性实例包括选自以下的物质:月桂基硫酸钠、月桂基硫酸铵、月桂基醚硫酸铵、月桂基醚硫酸钠、十三烷基醚硫酸钠、鲸蜡基硫酸铵、鲸蜡基硫酸钠、椰油酰羟乙磺酸铵、月桂酰羟乙磺酸钠、月桂酰乳酸钠、月桂酰乳酸三乙醇胺、己酰乳酸钠、月桂酰肌氨酸钠、肉豆蔻酰肌氨酸钠、月桂酰甲基牛磺酸钠、椰油酰甲基牛磺酸钠、月桂酰谷氨酸钠、肉豆蔻酰谷氨酸钠和椰油酰谷氨酸钠,及其混合物。 Preferred herein Nonlimiting examples of anionic lathering surfactants include those selected from the following materials: sodium lauryl sulfate, ammonium lauryl sulfate, lauryl ether sulfate, lauryl ether sulfate, sodium tridecyl ether sulfate sodium cetyl sulfate, sodium cetyl sulfate, ammonium cocoyl isethionate, sodium lauroyl isethionate, sodium lauroyl lactylate, triethanolamine lauroyl lactylate, caproyl lactylate, lauroyl sarcosine sodium, sodium myristoyl sarcosinate, sodium lauroyl methyl taurate, sodium cocoyl methyl taurate, sodium lauroyl glutamate, myristoyl glutamate, and sodium cocoyl glutamate sodium, and mixtures thereof.

尤其优选月桂基硫酸铵、月桂基醚硫酸铵、月桂酰乳酸钠和月桂酰乳酸三乙醇胺。 Especially preferred ammonium lauryl sulfate, ammonium laureth sulfate, sodium lauroyl lactylate, and triethanolamine lauroyl lactylate.

非离子起泡型表面活性剂用于本发明组合物中的非离子起泡型表面活性剂的非限制性实例公开于McCutcheon的洗涤剂与乳化剂,北美版(1986),AlluredPublishing Corporation出版;和McCutcheon的功能物质,北美版(1992);两文献都全部引入作为参考。 Nonionic lathering surfactants Non-limiting examples of compositions according to the present invention, nonionic lathering surfactants are disclosed in McCutcheon's Detergents and Emulsifiers, North American Edition (1986), AlluredPublishing Corporation publication; and McCutcheon's, functional materials, North American Edition (1992); two documents are hereby incorporated by reference.

用于本发明的非离子起泡型表面活性剂包括烷基葡糖苷、烷基多葡糖苷、多羟基脂肪酸酰胺、烷氧基化脂肪酸酯、蔗糖酯、胺氧化物及其混合物。 Nonionic lathering surfactants useful in the present invention include alkyl glucosides, alkyl polyglucosides, polyhydroxy fatty acid amides, alkoxylated fatty acid esters, sucrose esters, amine oxides and mixtures thereof.

可在此使用的烷基糖苷和烷基聚糖苷,它可概括地定义为长链醇(如C8-C30醇)与糖或淀粉聚合物即糖苷或聚糖苷的缩合产物的。 As used herein, may be alkyl glycosides and alkyl polyglycosides, which can be broadly defined as long chain alcohols (e.g., C8-C30 alcohol) with sugar or starch polymers i.e., glycosides or polyglycosides condensation products. 这类化合物可用式(S)nOR表示,式中S是糖部分如葡萄糖、果糖、甘露糖和半乳糖,n是约1-约1000的整数,R是C8-C30烷基。 Such compounds may be of formula (S) represented nOR, where S is a sugar moiety such as glucose, fructose, mannose and galactose, n being an integer of from about 1 to about 1000, R is a C8-C30 alkyl. 衍生出烷基的长链醇实例包括癸醇、鲸蜡醇、硬脂醇、月桂醇、肉豆蔻醇、油醇等。 Examples of long chain alcohols derived from alkyl groups include decyl alcohol, cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol, oleyl alcohol and the like. 这些表面活性剂优选的实例包括S是葡萄糖部分、R是C8-C20烷基、n是约1-约9整数的那些化合物。 Preferred examples of surfactants which include S is a glucose moiety, R is a C8-C20 alkyl, n is from about 1 to about 9 those compounds integer. 这些表面活性剂中可商购的实例包括癸基聚糖苷(可从Henkel公司购买的APG325CS)和月桂基聚糖苷(可从Henkel公司购买的APG600CS及625CS)。 These surfactants may be commercially available examples include decyl polyglucoside (available from Henkel Corporation APG325CS) and lauryl polyglucoside (available from Henkel Corporation APG600CS and 625CS). 也可以采用蔗糖酯表面活性剂,如椰油酸蔗糖酯和月桂酸蔗糖酯。 It may also be employed as sucrose ester surfactants such as sucrose cocoate and sucrose laurate esters.

其它适用的非离子表面活性剂包括相应于下列结构式的多羟基脂肪酸酰胺表面活性剂,更具体的实例包括葡糖酰胺: Other suitable nonionic surfactants include the following structural formula corresponding to polyhydroxy fatty acid amide surfactants, more specific examples include glucamide: 式中R1是H、C1-C4烷基、2-羟乙基、2-羟基丙基,优选C1-C4烷基,更优选甲基或乙基,最优选甲基;R2是C5-C31烷基或链烯基,优选C7-C19烷基或链烯基,更优选C9-C17烷基或链烯基,最优选C11-C15烷基或链烯基;Z是至少有3个羟基直接连到链上的具有线型烃基链的多羟基烃基部分或它们的烷氧基化(优选乙氧基化或丙氧基化)衍生物。 Wherein R1 is H, C1-C4 alkyl, 2-hydroxyethyl, 2-hydroxypropyl, preferably C1-C4 alkyl, more preferably methyl or ethyl, most preferably methyl; R2 is C5-C31 alkyl or alkenyl group, preferably C7-C19 alkyl or alkenyl, more preferably C9-C17 alkyl or alkenyl, most preferably C11-C15 alkyl or alkenyl group; Z is at least 3 hydroxyls directly connected to a polyhydroxyhydrocarbyl moiety having a linear hydrocarbyl chain in the chain thereof or alkoxylated (preferably ethoxylated or propoxylated) derivatives. 优选的Z选自葡萄糖、果糖、麦芽糖、乳糖、半乳糖、甘露糖、木糖及它们混合物的糖部分。 Z preferably selected from glucose, fructose, maltose, lactose, galactose, mannose, xylose, and mixtures thereof sugar moiety. 相应于上述结构的特别优选的表面活性剂是椰油烷基N-甲基糖苷酰胺(即,其中R2CO-部分是由椰油油脂肪酸衍生得到的)。 Corresponding to the above structure is particularly preferred surfactants are coconut alkyl N- methyl glucoside amide (i.e., wherein the R2CO- moiety is derived from coconut oil fatty acid-derived). 制备含多羟基脂肪酸酰胺组合物的方法已公开在例如英国专利说明书809060(Thomas Hedley & Co.Ltd.1959年2月18日公布)、E. R.Wilson的美国专利2965576(1960年12月20日授权)、AM Schwartz的美国专利2703798(1955年3月8日授权)、Piggott的美国专利1985424(1934年12月25日授权)中,这些内容已全部列入本文供参考。 Process for preparing polyhydroxy fatty acid amide-containing compositions have been disclosed in, for example, British Patent Specification 809060 (Thomas Hedley & amp;. Co.Ltd published February 18, 1959), in U.S. Patent No. 2,965,576 ERWilson (December 20, 1960 authorized ), US Patent 2,703,798 AM Schwartz's (March 8, 1955 authorization), Piggott, US Patent 1,985,424 (December 25, 1934 authorization), the contents of which have been incorporated herein by reference.

非离子表面活性剂的其它例子有胺氧化物。 Other examples of nonionic surfactants are amine oxides. 胺氧化物是与通式R1R2R3NO对应的物质,其中R1为烷基、烯基或一羟烷基,具有约8到约18个碳原子和0到约10个氧化乙烯部分以及0到约1个甘油基部分,R2和R3含有约1到约3个碳原子和0到约1个羟基,如甲基、乙基、丙基、羟乙基或羟丙基。 Amine oxides are materials corresponding to the general formula R1R2R3NO, wherein R1 is an alkyl, alkenyl or a hydroxyalkyl group having from about 8 to about 18 carbon atoms and from 0 to about 10 ethylene oxide moieties and from 0 to about 1 glyceryl moiety, R2 and R3 contain from about 1 to about 3 carbon atoms and from 0 to about 1 hydroxy group, e.g., methyl, ethyl, propyl, hydroxyethyl or hydroxypropyl. 通式中的箭头为半极性键的习惯表示。 Arrow formula represents a semipolar bond as customary. 适用于本发明的胺氧化物的例子有二甲基十二烷基氧化胺、油基二(2-羟乙基)氧化胺、二甲基辛基氧化胺、二甲基癸基氧化胺、二甲基十四烷基氧化胺、3,6,9-三氧杂十七烷基二乙基氧化胺、二(2-羟乙基)十四烷基氧化胺、2-十二烷氧基乙基二甲基氧化胺、3-十二烷氧基-2-羟丙基二(3-羟丙基)氧化胺、二甲基十六烷基氧化胺。 Examples of amine oxides suitable for the present invention include dimethyl-dodecylamine oxide, oleyldi (2-hydroxyethyl) amine oxide, octyl dimethyl amine oxide, decyl dimethyl amine oxide, tetradecyl dimethyl amine oxide, 3,6,9-heptadecyl oxygen hetero diethylamine oxide, bis (2-hydroxyethyl) tetradecylamine oxide, 2-dodecyloxy ethyl dimethyl amine oxide, 3-dodecyloxy-2-hydroxypropyl bis (3-hydroxypropyl) amine oxide, hexadecyl amine oxide, dimethyl.

此处适用的优选非离子表面活性剂的非限制性的例子有选自于C8-C14葡糖酰胺、C8-C14烷基聚糖苷、蔗糖椰油酸酯、蔗糖月桂酸酯、月桂氧化胺、椰油氧化胺及其混合物。 Non-limiting examples of surfactants useful herein are preferably nonionic in selected from C8-C14 glucose amides, C8-C14 alkyl polyglucosides, sucrose cocoate, sucrose laurate, lauryl amine oxide, cocoamine oxide and mixtures thereof.

两性起泡型表面活性剂术语“两性起泡型表面活性剂”在这里也包括两性离子表面活性剂,它是本领域配剂师熟知的两性表面活性剂的一个子部分。 Amphoteric lathering surfactants, the term "amphoteric lathering surfactant" as used herein also includes zwitterionic surfactants, which are well known in the art formulators a sub-portion of amphoteric surfactants.

多种两性表面活性剂可适用于本发明组合物。 More amphoteric surfactants in the compositions of the present invention is applicable. 尤其有用的是那些广义地描述为脂族仲胺和叔胺的衍生物,优选其中氮为阳离子状态,其中脂族基团可以是直链或支链型,其中一个基团含有可离子化的水溶性基团,如羧基、磺酸根、硫酸根、磷酸根或膦酸根。 Particularly useful are those broadly described as derivatives of aliphatic secondary and tertiary amines, preferably wherein the nitrogen is in a cationic state, in which the aliphatic radicals can be straight-chain or branched, wherein one of the radicals contains an ionizable water-solubilizing group, e.g. carboxy, sulfonate, sulfate, phosphate, or phosphonate.

用于本发明组合物中的两性表面活性剂的非限制性实例公开于McCutcheon的洗涤剂与乳化剂,北美版(1986),AlluredPublishing Corporation出版;和McCutcheon的功能物质,北美版(1992);两文献都全部引入作为参考。 Non-limiting examples of amphoteric surfactants in the compositions of the invention the active agent is disclosed in McCutcheon's Detergents and Emulsifiers, North American Edition (1986), AlluredPublishing Corporation publication; and McCutcheon's, Functional Materials, North American Edition (1992); two all documents are incorporated by reference.

非限定性的两性或两性离子表面活性剂的实例选自甜菜碱、磺基甜菜碱、羟基磺基甜菜碱、烷基亚氨基乙酸盐、亚氨基二烷酸盐、氨基烷酸盐及其混合物。 Non-limiting examples of amphoteric or zwitterionic surfactants selected from betaines, sulfo betaines, hydroxy sulfo betaines, alkyl imino acetates, alkyl iminodiacetic acid salts, amino acids, and alkyl mixture.

甜菜碱的例子包括高级烷基甜菜碱,如椰油基二甲基羧甲基甜菜碱、月桂基二甲基羧甲基甜菜碱、月桂基二甲基α-羧乙基甜菜碱、鲸蜡基二甲基羧甲基甜菜碱、鲸蜡基二甲基甜菜碱(购自Lonza公司的Lonzaine 16SP)、月桂基双(2-羟乙基)羧甲基甜菜碱、硬脂基双(2-羟丙基)羧甲基甜菜碱、油基二甲基γ-羧丙基甜菜碱、月桂基双(2-羟丙基)α-羧乙基甜菜碱、椰油基二甲基磺丙基甜菜碱、硬脂基二甲基磺丙基甜菜碱、硬脂基甜菜碱、月桂基二甲基磺乙基甜菜碱、月桂基双(2-羟乙基)磺丙基甜菜碱、和酰氨基甜菜碱和酰氨基磺基甜菜碱(其中RCONH(CH2)3基团连至甜菜碱的氮原子上)、油基甜菜碱(购自Henkel的两性Velvetex OLB-50)和椰油酰胺丙基甜菜碱(购自Henkel的Velvetex BK-50和BA-35)。 Examples of betaines include the higher alkyl betaines, such as coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl α- carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, cetyl dimethyl betaine (available from Lonza, Inc. of Lonzaine 16SP), lauryl bis- (2-hydroxyethyl) carboxymethyl betaine, stearyl bis- (2 - hydroxypropyl) carboxymethyl betaine, oleyl dimethyl γ- carboxypropyl betaine, lauryl bis- (2-hydroxypropyl) alpha] carboxyethyl betaine, coco dimethyl sulfopropyl betaine, stearyl dimethyl sulfopropyl betaine, stearyl betaine, lauryl dimethyl sulfoethyl betaine, lauryl bis- (2-hydroxyethyl) sulfopropyl betaine, and amido betaines and amido sulfobetaines (wherein the RCONH (CH2) 3 group is attached to the nitrogen atom of the betaine), oleyl betaine (available from Henkel amphoteric Velvetex OLB-50) and cocamide propyl betaine (commercially available from Henkel Velvetex BK-50 and BA-35).

磺基甜菜碱和羟基磺基甜菜碱的实例包括例如椰油酰胺丙基羟基磺基甜菜碱(购自Rhone-Poulenc的Mirataine CBS)。 Examples of sultaines and hydroxy sultaines include, for example, cocamidopropyl hydroxy sultaine (commercially available from Rhone-Poulenc of Mirataine CBS).

这里优选的两性表面活性剂具有以下结构: Here Preferred amphoteric surfactants having the following structure: 其中R1为具有约9至约22个碳原子的未取代的、饱和或未饱和的、直链或支化的链烷基。 Wherein R1 is an unsubstituted having from about 9 to about 22 carbon atoms, saturated or unsaturated, straight-chain or branched-chain alkyl groups. R1优选约11至约18个碳原子,更优选约12至约18个碳原子,进一步优选约14至约18个碳原子;m为1至约3的整数;更优选约2至约3,进一步优选约3的整数;n为0或1,优选1;R2和R3各自选自1至约3个碳原子的烷基、它可为未取代的或被羟基单取代的,优选R2和R3为CH3;X选自CO2、SO3和SO4;R4选自具有1至约5个碳原子的、饱和或未饱和的、直链或支化的烷基,它可未取代或被羟基单取代。 R1 is preferably from about 11 to about 18 carbon atoms, more preferably from about 12 to about 18 carbon atoms, more preferably from about 14 to about 18 carbon atoms; m is an integer from 1 to about 3; and more preferably about 2 to about 3, more preferably an integer of from about 3; n is 0 or 1, preferably 1; R2 and R3 are each selected from alkyl of 1 to about 3 carbon atoms which may be unsubstituted or monosubstituted with hydroxy, preferred R2 and R3 it is CH3; X is selected from CO2, SO3 and SO4; R4 is selected from 1 to about 5 carbon atoms, saturated or unsaturated, straight-chain or branched alkyl, which may be unsubstituted or mono-substituted hydroxy. 当X为CO2,R4优选具有1或3个碳原子、更优选1个碳原子。 When X is CO2, R4 preferably has 1 or 3 carbon atoms, more preferably 1 carbon atom. 当X为SO3或SO4时,R4优选具有约2至约4个碳原子,更优选3个碳原子。 When X is SO3 or SO4 time, R4 preferably has from about 2 to about 4 carbon atoms, more preferably 3 carbon atoms.

本发明的两性表面活性剂的实例包括以下化合物:鲸蜡基二甲基甜菜碱(该物质也具有CTFA命名鲸蜡基甜菜碱) Examples of amphoteric surfactants of the present invention include the following compounds: Cetyl dimethyl betaine (this material also has the CTFA designation cetyl betaine) 椰油酰胺丙基甜菜碱 Cocamidopropyl betaine

其中R具有约9至约13个碳原子,椰油酰胺丙基羟基磺基甜菜碱 Wherein R has from about 9 to about 13 carbon atoms Cocamidopropyl hydroxy sultaine 其中R具有约9至约13个碳原子,其它适用的两性表面活性剂的实例有烷基亚氨基乙酸盐、亚氨基二烷酸盐和氨基烷酸盐,通式为RN[(CH2)mCO2M]2和RNH(CH2)mCO2M,其中m为1-4,R为C8-C22烷基或烯基,M为H、碱金属、碱土金属、铵或烷醇铵。 Wherein R has from about 9 to about 13 carbon atoms, examples of other suitable amphoteric surfactants are alkyl imino acetates, iminodiacetic acid and amino alkyl alkanoates, the formula RN [(CH2) mCO2M] 2 and RNH (CH2) mCO2M, wherein m is 1-4, R is a C8-C22 alkyl or alkenyl group, m is H, alkali metal, alkaline earth metal, ammonium or alkanolammonium. 还包括咪唑啉鎓盐和铵盐的衍生物。 Further comprising derivatives of imidazolinium salts and ammonium. 适用的两性表面活性剂的特定实例包括3-十二烷基-氨基丙酸钠、3-十二烷基氨基丙烷磺酸钠、N-高级烷基天门冬氨酸,如按照引入本文为参考的USP2438091中的方法制备的;在引入本文为参考的USP2528378中描述的以商品名“Miranol”出售的产品。 Specific examples of suitable amphoteric surfactants include 3-dodecyl - amino propionate, sodium 3-dodecylaminopropane sulfonate, N- higher alkyl aspartic, incorporated herein by reference as follow tradename described herein are incorporated by reference in USP2528378 "Miranol" product sold; prepared by the method of the USP2438091. 其它适用的两性表面活性剂包括磷酸盐,如椰油酰胺丙基氯化PG-dimonium磷酸盐(购自Mona公司的Monaquat PTC)。 Other suitable amphoteric surfactants include phosphates, such as cocamidopropyl PG-dimonium chloride phosphate (commercially available from Mona's Monaquat PTC). 也可以采用两性乙酸盐,例如月桂基两性二乙酸二钠、月桂基两性乙酸钠及其混合物。 Amphoteric acetates may also be employed, such as sodium lauryl amphoteric disodium, sodium lauryl amphoacetate and mixtures thereof.

此处适用的优选起泡型表面活性剂有以下一些,其中阴离子起泡型表面活性剂选自于月桂酰基肌氨酸铵、十三烷基醚硫酸钠、月桂酰基肌氨酸钠、月桂基醚硫酸铵、月桂基醚硫酸钠、月桂基硫酸铵、月桂基硫酸钠、椰油酰基羟乙磺酸铵、椰油酰基羟乙磺酸钠、月桂酰基羟乙磺酸钠、十六烷基硫酸钠、月桂酰乳酸钠、三乙醇胺(TEA)月桂酰乳酸盐,及其混合物;其中非离子起泡型表面活性剂选自于月桂氧化胺、椰油氧化胺、癸基聚葡糖、月桂基聚葡糖、蔗糖椰油酸酯、C12-C14葡糖酰胺、蔗糖月桂酸酯及其混合物;其中两性起泡型表面活性剂选自于月桂两性二乙酸二钠、月桂两性乙酸钠、二甲基十六烷基甜菜碱、椰油酰氨丙基甜菜碱、椰油酰氨丙基羟基磺基甜菜碱及其混合物。 Suitable for use herein preferably lathering surfactants are some of the following, wherein the anionic lathering surfactant is selected from ammonium lauroyl sarcosinate, tridecyl ether sulfate, sodium lauroyl sarcosinate, lauryl ether sulfate, lauryl ether sulfate, ammonium lauryl sulfate, sodium lauryl sulfate, ammonium cocoyl-hydroxyphenyl acetic acid, sodium cocoyl isethionate, sodium lauroyl isethionate, sodium cetyl sulfate, sodium lauroyl lactylate, triethanolamine (TEA) lauroyl lactate, and mixtures thereof; wherein the nonionic lathering surfactant is selected from lauryl amine oxide, cocoamine oxide, decyl polyglucose, lauryl group polyglucose, sucrose cocoate, C12-C14 glucamides, sucrose laurate, and mixtures thereof; wherein the amphoteric lathering surfactant is selected from amphoteric lauryl disodium lauryl sodium cocoamphoacetate, two methyl hexadecyl betaine, cocoamidopropyl betaine, cocoamidopropyl hydroxy sultaine, and mixtures thereof.

调理乳液本发明产品含有调理乳液,该乳液适用于在产品的使用中提供给皮肤或毛发调理性能。 Products of the present invention contains conditioning emulsion conditioning emulsion, the emulsion is applied to the skin or hair to provide conditioning properties in the use of the product. 该调理乳液为水不溶性基质重量的约0.25%到约150%,优选地约0.5%到约100%,更优选地约1%到约50%。 The conditioning emulsion is a water-insoluble substrate about 0.25 wt% to about 150%, preferably from about 0.5% to about 100%, more preferably from about 1% to about 50%. 调理乳液指的是在含有水溶性调理剂的内相外包围着含有油溶性试剂的外相的组合。 It refers to a combination of conditioning emulsion external phase in the outer phase containing a water soluble conditioning agent comprising an oil soluble agent around. 在优选的实施方案中,调理乳液可进一步包含乳化剂。 In preferred embodiments, the conditioning emulsion further comprises an emulsifier.

本发明的调理乳液包含(i)包含水溶性调理剂的内相,和(ii)包含油溶性试剂的外相。 Conditioning emulsion of the present invention comprises (i) an internal phase comprising water soluble conditioning agent, and (ii) the external phase comprising an oil soluble agent. 在另一实施方案中,调理乳液进一步包含能够形成由所述的内相和外相组成的乳液的乳化剂。 In another embodiment, the conditioning emulsion further comprises an emulsifier capable of forming an emulsion of said internal and external phases of the compositions. 虽然在本发明中能够形成由所述的内相和外相组成的乳液的乳化剂是优选的,但是对于皮肤护理配方领域中的技术人员熟知的是,水溶性调理剂可以在没有乳化剂的条件下被油溶性试剂所包封。 Although an emulsifier capable of forming an emulsion of said internal and external phases in the composition of the present invention is preferred, but formulations for skin care in the art is well known to the art, a water soluble conditioning agent may be used without emulsifier conditions the encapsulated by the oil soluble agent. 只要水溶性调理剂被油溶性试剂所包封,在清洗时就可防止被漂洗去,这样的组合物也在本发明的要求范围之内。 As long as water soluble conditioning agent is encapsulated by oil-soluble agent, can be prevented when the washing is rinsed, such compositions are also required range of the present invention.

油溶性试剂选自于一种或数种油溶性试剂,这些油溶性试剂的加权算术平均溶解度参数小于或等于10.5。 Oil soluble agent selected from one or several oil-soluble agent, weighted arithmetic mean solubility parameter of the oil soluble agent equal to or less than 10.5. 水溶性调理剂选自一种或多种水溶性调理剂,使得水溶性调理剂的加权算术平均溶解度参数大于10.5。 Water soluble conditioning agent selected from one or more water soluble conditioning agents, water soluble conditioning agents such that the weighted arithmetic mean solubility parameter greater than 10.5. 已认定,基于溶解度参数的这种数学定义,对于含有两种或数种化合物的油溶性调理剂,如果其中一种化合物的单独溶解度参数大于10.5,就有可能达到所需的加权算术平均溶解度参数,即小于或等于10.5。 Have determined that this mathematical definition of solubility parameters based on, for oil soluble conditioning agent comprising two or several compounds, if one of the individual solubility parameter greater than 10.5 compound, it is possible to achieve the required weighted arithmetic mean solubility parameter , i.e. less than or equal to 10.5. 相反,如果一种化合物单独的溶解度参数小于或等于10.5,对于包含两种或多种化合物的水溶性调理剂来说可以获得合适的加权算术平均溶解度参数,即大于10.5。 Conversely, if the compound alone or equal to a solubility parameter of less than 10.5, for a water soluble conditioning agent comprising two or more compounds may be obtained suitable for the weighted arithmetic mean solubility parameter, i.e. greater than 10.5.

溶解度参数为本领域具有一般技能的配制化学工作者所熟知,而且日常中作为确定配制过程中物质的相容性和溶解性的指标。 Having a solubility parameter art formulation chemist of ordinary skill in the art, and as determined daily compatibility and solubility index material during formulation.

化合物的溶解度参数δ,其定义为该化合物内聚能密度的平方根。 Compound solubility parameter δ, which is defined as the square root of the cohesive energy density compound. 典型的是,一种化合物的溶解度参数是通过查表找出加和基团对该化合物组分的气化热和摩尔体积的贡献值,利用下式进行计算:δ=[ΣiEiΣimi]1/2]]>式中∑iEi=加和基团贡献的气化热之和∑imi=加和基团贡献的摩尔体积之和对于各种原子和原子团,其加和基团对气化热和摩尔体积的贡献值的标准表收集在Barton,AFM溶解度参数手册,CRC Press,第6章,卷3,pp.64-66(1985),这部分内容在此被完全引用作为参考。 Typically, a solubility parameter of a compound is calculated by a look-up table to find the contribution of the heat of vaporization additive group compound component and the molar volume, using the following equation: & delta; = [& Sigma; iEi & Sigma; imi] 1/2]]> where ΣiEi = additive group contributions sum Σimi = heat of vaporization additive group contributions molar volume and for a variety of atoms and atomic groups, and adding it to the group standard tables of heat of vaporization and molar volume contribution collected in Barton, AFM solubility parameter Manual, CRC Press, Chapter 6, vol. 3, pp.64-66 (1985), part of which is completely incorporated herein by reference . 上面的溶解度参数方程在Fedors,RF,“估算液体溶解度参数和摩尔体积的方法”,聚合物科学与工程,vol.14,no.2,pp.147-154(1974年2月)中有描述,这部分内容在此被完全引用作为参考。 The above solubility parameter equation in Fedors, RF, "method of estimating the liquid molar volume and solubility parameter," Polymer Science and Engineering, vol.14, no.2, pp.147-154 in (February 1974) described this part is hereby fully incorporated by reference.

溶解度参数服从混合定法则,即混合物的溶解度参数为该混合物中每个组分溶解度参数的加权算术平均值(即加权平均值)。 Solubility parameters obey the law of constant mixing, i.e., the solubility parameter of the mixture (i.e. the weighted average) for each of the mixture components of the weighted arithmetic mean solubility parameter. 见化学和物理手册,第57版,CRC Press,pC-726(1976-1977),这部分内容在此被完全引用作为参考。 See chemical and physical Handbook, 57th Edition, CRC Press, pC-726 (1976-1977), this part of the contents of which are fully incorporated by reference.

配剂师通常报道和使用的溶解度参数的单位是(卡/厘米3)1/2。 Unit formulators usually reported and solubility parameter used is (cal / cm 3) 1/2. 在溶解度参数手册报道的列表中,加和基团对气化热的贡献值单位为千焦/摩尔。 In the list of solubility parameters reported in the manual, and add the group to the heat of vaporization contribution value in units of kJ / mol. 但是,利用下面这个熟知的关系式很容易将该表中的气化热转化为卡/摩尔。 However, the use of the following well-known relationship easily the heat of vaporization of the table is converted to cal / mole.

1焦/摩尔=0.239006卡/摩尔 1000焦=1千焦见Gordon,AJ等人The Chemist's Companion,JohnWiley&Sons,pp.456-463,(1972),这部分内容在此被完全引用作为参考。 1 J / mol = 0.239006 cal / mol 1 = 1000 kJ power See Gordon, AJ et al., The Chemist's Companion, JohnWiley & amp; Sons, pp.456-463, (1972), part of which is completely incorporated herein by reference.

还有许多种化学物质的溶解度参数制成表格。 There are many kinds of chemicals solubility parameter of tabulated. 这些溶解度参数表在上面引用的溶解度参数手册中可以找到。 The solubility parameter tables can be found in the above referenced solubility parameter manual. 也可以参见CDVaughan著的化妆品和盥洗用品一书中“在产品、包装、渗透和防腐中的溶解度效应”一文,103卷,1988年10月,pp47-69,这里全文引入作为参考。 See also CDVaughan with cosmetics and toiletries in his book "In the products, packaging, penetration and solubility effect of preservative," a text, Volume 103, October 1988, pp47-69, which is hereby incorporated by reference.

调理乳液的外相调理乳液的外相包含油溶性试剂。 Foreign Minister Foreign Secretary conditioning emulsion containing conditioning emulsion of oil-soluble agent. 任何油溶性试剂或加权算术平均溶解度参数小于或等于10.5的油溶性试剂的组合都可在外相中应用。 Any oil soluble agent or a weighted arithmetic mean solubility parameter of less than or equal to a combination of an oil-soluble agent can be in the outer phase 10.5 of the application. 优选地,油溶性试剂是一种用于调理皮肤或毛发的油溶性调理剂。 Preferably, oil-soluble agent is an oil soluble conditioning agent for skin or hair for conditioning.

这里使用的油溶性调理剂的非限定性实例选自:矿物油、矿脂、羊毛脂、C7~C40支化链烃、表皮和皮脂烃、脂肪酸酯如C1~C30羧酸C1~C30醇酯、多元醇多酯如C2~C30二羧酸C1~C30醇酯、C1~C30羧酸单甘油酯、二甘油酯和三甘油酯、C1~C30羧酸乙二醇单酯和二酯、C1~C30羧酸丙二醇单酯和二酯、C1~C30羧酸糖单酯和多酯、非离子聚合物、聚硅氧烷油、聚硅氧烷胶、聚二烷基硅氧烷、聚二芳基硅氧烷、聚烷芳基硅氧烷、3至9个硅原子的环甲基聚硅氧烷、植物油、氢化植物油、植物油加合物、聚丙二醇C4~C20烷基醚、二C8~C30烷基醚及其混合物。 Non-limiting examples of oil soluble conditioning agents herein are selected from: mineral oil, petrolatum, lanolin, C7 ~ C40 branched chain hydrocarbons, epidermal and sebaceous hydrocarbons, fatty acid esters such as C1 ~ C30 C1 ~ C30 alcohol esters, polyol esters such as C1 ~ C30 alcohol esters of C2 ~ C30 dicarboxylic acids, C1 ~ C30 acid monoglycerides, diglycerides and triglycerides, C1 ~ C30 carboxylic acid monoesters and diesters of ethylene glycol, C1 ~ C30 carboxylic acid monoesters and diesters of propylene glycol, C1 ~ C30 carboxylic acid monoesters and polyesters of sugar, nonionic polymer, silicone oils, silicone gums, polydimethyl siloxanes, poly diaryl siloxanes, polyalkylaryl siloxanes, cyclomethicones having 3 to 9 silicon atoms, vegetable oils, hydrogenated vegetable oils, vegetable oil adducts, polypropylene glycol C4 ~ C20 alkyl ethers, di C8 ~ C30 alkyl ethers, and mixtures thereof.

矿物油,也称液态矿脂,是从矿脂中得到的液态烃的混合物。 Mineral oil, also known as petrolatum liquid, is a mixture obtained from petrolatum liquid hydrocarbons. 见“默克索引”,第10版,第7048条,第1033页(1983)和“国际化妆品成分词典”,第5版,卷1,第415-417页(1993),全部引入作为参考。 See "The Merck Index", 10th Edition, entry 7048, p. 1033 (1983) and "International Cosmetic Ingredient Dictionary," 5th Edition, Vol. 1, pp. 415-417 (1993), hereby incorporated by reference.

矿脂,也称石油胶,是胶体体系的非直链固态烃和高沸点的液态烃,其中绝大多数液态烃包含在胶束内。 Petrolatum is also known as petroleum jelly, is a non-linear liquid hydrocarbon chain solid hydrocarbons and high-boiling colloidal systems, and most of the liquid hydrocarbons contained in the micelles. 见“默克索引”,第10版,第7047条,第1033页(1983);Schindler的“Drug.Cosmet.Ind.”,89,36~37,76,78~80,82(1961);以及“国际化妆品成分词典”,第5版,卷1,第537页(1993),它们全部引入作为参考。 See "The Merck Index", 10th Edition, entry 7047, p. 1033 (1983); Schindler's "Drug.Cosmet.Ind.", 89,36 ~ 37,76,78 ~ 80,82 (1961); and "international cosmetic ingredient Dictionary," 5th Edition, Vol. 1, p. 537 (1993), all of which are incorporated herein by reference.

这里可以使用具有约7至约40个碳原子的直链和支链烃。 Here Straight and branched chain hydrocarbons having from about 7 to about 40 carbon atoms. 这些烃物质的非限定性实例包括十二烷、异十二烷、角鲨烷、胆固醇、氢化聚异丁烯、二十二烷烃、十六烷、异十六烷(商购有Permethyl101A,Presperse公司,South Plainfield,NJ)。 Non-limiting examples of these hydrocarbon materials include dodecane, isododecane, squalane, cholesterol, hydrogenated polyisobutylene, di-dodecane, hexadecane, isohexadecane (a commercially available have Permethyl101A, Presperse company, South Plainfield, NJ). 也可以用C7~C40异链烷烃,它们是C7~C40支化烃。 Can also be used C7 ~ C40 isoparaffins, which are C7 ~ C40 branched hydrocarbons.

适用的油还包括C1~C30羧酸和C2~C30二羧酸的C1~C30醇酯,包括直链和支链化合物及其芳族衍生物。 Suitable oils include further C1 ~ C30 carboxylic acids and C1 ~ C30 alcohol esters of C2 ~ C30 dicarboxylic acids, including straight-chain and branched-chain compounds and aromatic derivatives. 其它适用的酯包括C1~C30羧酸单甘油酯、二甘油酯和三甘油酯、C1~C30羧酸乙二醇单酯和二酯,C1~C30羧酸的丙二醇单酯和双酯。 Other suitable esters include C1 ~ C30 acid monoglycerides, diglycerides and triglycerides, C1 ~ C30 carboxylic acid monoesters and diesters of ethylene glycol, propylene glycol monoesters of C1 ~ C30 carboxylic acids and diesters. 直链、支链和芳基羧酸也包括在内。 Straight chain, branched chain and aryl carboxylic acids are included. 也可以使用这些物质的丙氧基化和乙氧基化的衍生物。 Propoxylated and ethoxylated derivatives of these materials may also be used. 非限定实例包括癸二酸二异丙酯、己二酸二异丙酯、肉豆蔻酸异丙酯、棕榈酸异丙酯、丙酸肉豆蔻酯、二硬脂酸乙二醇酯、棕榈酸(2-乙基-己)酯、新戊酸异癸酯、马来酸二(2-乙基-己)酯、棕榈酸鲸蜡酯、肉豆蔻酸肉豆蔻酯、硬脂酸硬脂酯、硬脂酸鲸蜡酯、二十二烷酸二十二烷酯、马来酸二辛酯、癸二酸二辛酯、己二酸二异丙酯、辛酸鲸蜡醇、二亚油酸二异丙酯、辛酸/癸酸三甘油酯、PEG-6辛酸/癸酸三甘油酯、PEG-8辛酸/癸酸三甘油酯及其混合物。 Nonlimiting examples include diisopropyl sebacate, diisopropyl adipate, isopropyl myristate, isopropyl palmitate, myristyl propionate, ethylene glycol distearate, palmitic acid (2-ethyl - hexyl) acrylate, isodecyl neopentanoate, maleic acid (2-ethyl - hexyl) ester, cetyl palmitate, myristyl myristate, stearyl stearate , cetyl stearate, behenic acid dodecyl ester, dioctyl maleate, dioctyl sebacate, diisopropyl adipate, cetyl octanoate, dilinoleate diisopropyl ester, caprylic / capric triglyceride, PEG-6 caprylic / capric triglyceride, PEG-8 caprylic / capric triglyceride, and mixtures thereof.

也可以使用糖的各种C1-C30单酯和多酯及相关物质。 Sugars may be used various C1-C30 monoesters and polyesters and related substances. 这些酯衍生自一个糖或多元醇部分及一个或多个羧酸部分。 These esters are derived from a sugar or polyol moiety and one or more carboxylic acid moieties. 取决于酸和糖成分,这些酯室温下可以呈液态或固态。 Depending on the acid component and sugar, these esters can be in liquid or solid at room temperature. 液态酯的实例包括:葡萄糖四油酸酯、豆油脂肪酸的葡萄糖四酯(未饱和)、混合豆油脂肪酸的麦芽糖四酯、油酸半乳糖四酯、亚油酸阿拉伯糖四酯、四亚油酸木糖酯、五亚油酸半乳糖酯、四油酸山梨醇酯、不饱和豆油脂肪酸山梨醇六酯、五油酸木糖醇酯、四油酸蔗糖酯、五油酸蔗糖酯、六油酸蔗糖酯、七油酸蔗糖酯、八油酸蔗糖酯及其混合物。 Examples of liquid esters include: glucose tetraoleate, the glucose tetraesters of soybean oil fatty acids (unsaturated), maltose tetraester mixed soybean oil fatty acids, the galactose tetraesters of oleic acid, the arabinose tetraesters of linoleic acid, tetralinoleate esters of xylose, galactose five linoleate ester, tetraoleate sorbitan esters, fatty acid sorbitol hexaesters of unsaturated soybean oil, xylitol pentaoleate, tetraethylene sucrose oleate, sucrose oleate five, six oil acid sucrose esters, sucrose oleate seven, eight sucrose oleate and mixtures thereof. 本发明的固态酯的例子是山梨醇六酯,其中的羧酸酯部分是摩尔比为1∶2的棕榈油酸酯和花生酸酯;蜜三糖的八酯,其中的羧酸酯部分是摩尔比为1∶3的亚油酸酯和二十二烷酸酯;麦芽糖的七酯,其中要酯化的羧酸部分是摩尔比为3∶4的向日葵籽油脂肪酸酯和二十四烷酸酯;蔗糖的八酯,其中要酯化的羧酸部分是摩尔比为2∶6的油酸酯和二十二烷酸酯;蔗糖的八酯,其中要酯化的羧酸部分是摩尔比为1∶3∶4的月桂酸酯、亚油酸酯和二十二烷酸酯。 Examples of solid esters of the present invention are sorbitol hexaester in which the carboxylic acid ester moiety is a molar ratio of ester of palm oil and peanut esters of 1:2; octaester of raffinose in which the carboxylic acid ester moiety is 1:3 molar ratio of linoleate and behenate; seven maltose ester, wherein the carboxylic acid moiety is esterified to a molar ratio of fatty acid ester of sunflower seed oil and lignoceric of 3:4 alkanoate; octaester of sucrose wherein the esterifying carboxylic acid moieties to a molar ratio of 2:6 oleate and behenate; octaester of sucrose wherein the esterifying carboxylic acid moieties are to be molar ratio of 1:3:4 laurate, linoleate and behenate. 一种优选的原料是酯化度为7-8的蔗糖聚酯,而且其中的脂肪酸部分是C18单与/或二不饱和羧酸和二十二烷酸,不饱和羧酸与二十二烷酸的摩尔比为1∶7到3∶5。 A preferred degree of esterification of the starting material is sucrose polyester 7-8, and wherein the fatty acid moieties are C18 mono and / or diunsaturated acid and behenic acid, unsaturated carboxylic acid and behenic the molar ratio of acid is 1.7 or to 3:5. 一种特别优选的固态糖多酯是分子中有约7个二十二烷酸脂肪酸部分和约1个油酸部分的蔗糖的八酯。 A particularly preferred solid sugar polyester is the octaester molecule about 7 behenic acid sucrose fatty acid moieties and about 1 oleic acid moiety. 其它物质包括蔗糖的棉籽油或大豆油脂肪酸酯。 Other materials include cottonseed oil or soybean oil, sucrose fatty acid esters. 酯在以下文献中有进一步的描述:1997年1月25日授予Jandacek的USP 2831854;USP4005196;USP4005195;1994年4月26日授权Letton等人的USPNo.5,306,516;1994年4月26日授权Letton等人的USPNo.5,306,515;1994年4月26日授权Letton等人的USPNo.5,305,514;1989年1月10日授权Jandacek等人的USPNo.4,797,300;1976年6月15日授权Rizzi等人的USPNo.3,963,699;1985年5月21日授权Volpenhein的USPNo.4,518,772;1985年5月21日授权Volpenhein的USPNo.4,517,360;以上所有内容在此均被全部引用作为参考。 There ester in the literature further described: January 25, 1997 granted Jandacek of USP 2831854; USP4005195;; USP4005196 April 26, 1994 authorized Letton, et al. USPNo.5,306,516; April 26, 1994 authorized Letton, etc. people USPNo.5,306,515; April 26, 1994 authorized Letton, et al. USPNo.5,305,514; 1989 years 10 1 Yue et al., issued Jandacek USPNo.4,797,300; 1976, issued on 6 Yue 15 USPNo.3,963,699 Rizzi, et al. ; May 21, 1985 authorized Volpenhein of USPNo.4,518,772; May 21, 1985 authorized Volpenhein of USPNo.4,517,360; all content herein above are fully incorporated by reference.

例如聚二烷基硅氧烷、聚二芳基硅氧烷、聚烷芳基硅氧烷的非挥发性的聚硅氧烷也是适用的油。 Polydialkylsiloxane e.g., polydimethyl siloxanes, polyalkylaryl siloxanes, non-volatile silicone oils are also suitable. 这些聚硅氧烷公开在USP5069897中,1991年12月3日授予Orr,该专利全文引入本文作为参考。 These silicones are disclosed in USP5069897, 1991 issued May 3 years 12 is Orr, which patent is incorporated herein by reference. 这样的聚烷基硅氧烷对应的通用化学式为R3SiO[R2SiO]xSiR3,式中R是烷基基团(优选的R是甲基或乙基,更优选甲基),x是0到大约500的整数,选择x可达到要求的分子量。 Such polyalkylsiloxanes correspond to the general chemical formula R3SiO [R2SiO] xSiR3, where R is an alkyl group (preferably R is methyl or ethyl, more preferably methyl), x is 0 to about 500 the integer x can be selected to achieve the desired molecular weight. 市购聚烷基硅氧烷包括聚二甲基硅氧烷,又名二甲聚硅氧烷,其非限制性的例子包括General Electric Company出售的Vicasil系列和Dow Corning Corporation出售的Dow Corning200系列。 Commercially available polyalkylsiloxanes include polydimethylsiloxanes, also known as dimethicone, non-limiting examples include Dow General Electric Company and sold by Vicasil series sold by Dow Corning Corporation Corning 200 series. 本发明中的聚二甲基硅氧烷的具体的例子包括粘度为10cs,沸点高于200℃的Dow Corning225流体;以及粘度分别为50,350和12,500cs,沸点高于200℃的Dow Corning200流体。 Specific examples of the polydimethylsiloxane in the present invention include viscosity 10cs, Dow Corning225 fluid having a boiling point higher than 200 ℃; and viscosities were 50, 350 and 12,500cs, having a boiling point higher than 200 ℃ Dow Corning 200 fluid. 可使用的物质还有例如三甲基甲硅烷氧基硅酸酯,它是一种聚合物,相应的通用化学式为[(CH2)3SiO1/2]x[SiO2]y,式中x为大约1到约500的整数,y为大约1到约500的整数。 There are substances such as trimethyl siloxy silicate may be used, which is a polymer corresponding to the general chemical formula [(CH2) 3SiO1 / 2] x [SiO2] y, wherein x is from about 1 to an integer of about 500, y is an integer of from about 1 to about 500. 市售三甲基甲硅烷氧基硅酸酯是以商品名DowCorning_593流体出售的与二甲聚硅氧烷的混合物。 Commercially available trimethyl siloxy silicate sold under the trade name DowCorning_593 fluid mixture with dimethyl polysiloxane. 本发明中使用的还有二甲聚硅氧烷醇,它是两端带羟基的聚二甲基硅氧烷。 The present invention also dimethiconol, which is polydimethylsiloxane with a hydroxy group at both ends. 这些物质可以由通用化学式R3SiO[R2SiO]xSiR2OH和HOR2SiO[R2SiO]xSiR2OH表示,式中R为烷基基团(优选的R是甲基或乙基,更优选的是甲基),x是0到大约500的整数,通过选择x达到要求的分子量。 These may be [R2SiO] xSiR2OH and HOR2SiO [R2SiO] xSiR2OH represented by the general chemical formula R3SiO, wherein R is an alkyl group (preferably R is methyl or ethyl, more preferably methyl), x is 0 to is an integer of about 500, by selecting the molecular weight required to achieve x. 市售二甲聚硅氧烷醇通常是以与二甲聚硅氧烷或环状聚甲基硅氧烷的混合物的形式出售(例如Dow Corning1401,1402和1403流体)。 Commercially available dimethicone alcohol usually in the form of a mixture with dimethicone or dimethicone sold poly cyclic (e.g. Dow Corning1401,1402 and 1403 fluids). 本发明中使用的还有聚烷基芳基硅氧烷,优选的是25℃下粘度在大约15到65cs之间的聚甲基苯基硅氧烷。 In the present invention there polyalkylaryl siloxanes, preferably a viscosity between about 15 to the methyl phenyl polysiloxane 65cs at 25 ℃. 这些物质都可获得,例如SF 1075甲基苯基流体(General Electric Company出售)和556Cosmetic Grade聚苯基三甲基硅氧烷流体(Dow Corning Corporation出售)。 These materials are available, such as SF 1075 methyl phenyl fluid (General Electric Company sold) and poly 556Cosmetic Grade phenyl trimethicone fluid (Dow Corning Corporation sold).

这里也可以使用植物油和氢化植物油及植物油加合物,其实例包括红花油、蓖麻油、椰子油、棉子油、鲱油、棕榈仁油、棕榈油、花生油、豆油、菜子油、亚麻籽油、米糠油、松油、芝麻油、向日葵油、氢化红花油、氢化蓖麻油、氢化椰油、氢化棉子油、氢化鲱油、氢化棕榈仁油、氢化棕榈油、氢化花生油、氢化豆油、氢化菜子油、氢化亚麻籽油、氢化米糠油、氢化芝麻油、氢化向日葵油及其混合物。 Used herein may be a vegetable oil and hydrogenated vegetable oils and vegetable oil adducts, and examples thereof include safflower oil, castor oil, coconut oil, cottonseed oil, menhaden oil, palm kernel oil, palm oil, peanut oil, soybean oil, rapeseed oil, linseed oil, rice bran oil, pine oil, sesame oil, sunflower oil, hydrogenated safflower oil, hydrogenated castor oil, hydrogenated coconut oil, hydrogenated cottonseed oil, hydrogenated menhaden oil, hydrogenated palm kernel oil, hydrogenated palm oil, hydrogenated peanut oil, hydrogenated soybean oil, hydrogenated rapeseed oil, hydrogenated linseed oil, hydrogenated rice bran oil, hydrogenated sesame oil, hydrogenated sunflower oil, and mixtures thereof.

也可以使用聚丙二醇的C4~C20烷基醚、聚丙二醇的C1~C20羧酸酯和二C8~C30烷基醚。 Polypropylene glycol may also be used in C4 ~ C20 alkyl ethers, polyethylene glycol esters of C1 ~ C20 carboxylic acids and di-C8 ~ C30 alkyl ethers. 这些物质的非限定性实例包括PPG-14丁基醚、PPG-15硬脂基醚、二辛基醚、十二烷基辛基醚及其混合物。 Non-limiting examples of these materials include PPG-14 butyl ether, PPG-15 stearyl ether, dioctyl ether, dodecyl octyl ether, and mixtures thereof.

调理乳液的内相调理乳液的内相包含水溶性调理剂。 Conditioning emulsion internal phase in the conditioning phase of the emulsion comprises a water soluble conditioning agent. 任何水溶性调理剂或加权算术平均溶解度参数大于10.5的水溶性调理剂的组合都可用于内相。 Any combination of water soluble conditioning agents or weighted arithmetic mean solubility parameter of the water soluble conditioning agent is greater than 10.5 can be used in the internal phase. 另外,任何列于“附加成分”和“活性成分”中的水溶性成分都可结合到调理乳液的内相中,只要水溶性成分与水溶性调理剂是相容的,而不会引起调理乳液的不稳定。 Further, any water-soluble components listed in the "additional ingredients" and "active ingredient" can be incorporated into the internal phase of the conditioning emulsion, as long as the water-soluble component and a water soluble conditioning agent are compatible, without causing conditioning emulsion instability.

适用作水溶性调理剂的调理剂的非限制性例子选自于多元醇、聚丙二醇、聚乙二醇、脲、吡咯烷酮羧酸、乙醇酸、乙氧基和/或丙氧基C3-C6二醇或三醇,α-羟基C2-C6羧酸、乙氧基和/或丙氧基糖、丙烯酸共聚物、具有高至约12个碳原子的糖,具有高至约12个碳原子的糖醇及其混合物。 Nonlimiting examples of conditioning agents useful as water soluble conditioning agent is selected from polyhydric alcohols, polyethylene glycol, polyethylene glycol, urea, pyrrolidone carboxylic acid, glycolic acid, ethoxylated and / or propoxylated C3-C6 two alcohol or triols, alpha] hydroxy C2-C6 carboxylic acids, ethoxylated and / or propoxylated sugars, acrylic acid copolymers, sugars having up to about 12 carbon atoms, up to about 12 carbon atoms, sugar and mixtures thereof. 适用的水溶性调理剂的具体例子有以下物质,如脲;胍;羟基乙酸和羟乙酸盐(如铵盐和烷基季铵盐);乳酸和乳酸盐(如铵盐和烷基季铵盐);吡咯烷酮羧酸钠(PCA钠);蔗糖、果糖、葡萄糖、eruthrose、赤藓醇、山梨醇、甘露醇、丙三醇、己三醇、丙二醇、丁二醇、己二醇、乙基己二醇等等;聚乙二醇如PEG-2、PEG-3、PEG-30、PEG-50,聚丙二醇如PPG-9、PPG-12、PPG-15、PPG-17、PPG-20、PPG-26、PPG-30、PPG-34;烷氧基葡萄糖;透明质酸;泛酰醇;烟酰胺,及其混合物。 Specific examples of suitable water soluble conditioning agents are the following substances, such as urea; guanidine; glycolic acid and glycolate salts (e.g. ammonium and quaternary alkyl ammonium); lactic acid and lactate salts (e.g. ammonium and quaternary alkyl salt); sodium pyrrolidone carboxylate (sodium the PCA); sucrose, fructose, glucose, eruthrose, erythritol, sorbitol, mannitol, glycerol, hexanetriol, propylene glycol, butanediol, hexanediol, b yl-hexanediol and the like; polyethylene glycols such as PEG-2, PEG-3, PEG-30, PEG-50, polypropylene glycols such as PPG-9, PPG-12, PPG-15, PPG-17, PPG-20 , PPG-26, PPG-30, PPG-34; alkoxylated glucose; hyaluronic acid; panthenol; niacinamide, and mixtures thereof. 同样适用的物质有任何形式的库拉索芦荟(如库拉索芦荟凝胶)、壳聚糖、蜂蜜提取物、淀粉接枝聚丙烯酸钠如Sanwet(RTM)IM-1000、IM1500和IM-2500(可从CelaneseSuperabsorbent Materials,Portsmouth,VA获得);乳酰胺单乙醇胺;乙酰胺单乙醇胺;及其混合物。 The same applies to any form of material Aloe vera (e.g., Aloe vera gel), chitosan, honey extract, starch-grafted sodium polyacrylates such as Sanwet (RTM) IM-1000, IM1500 and IM-2500 (available from CelaneseSuperabsorbent Materials, Portsmouth, VA); lactamide monoethanolamine; acetamide monoethanolamine; and mixtures thereof. 同样适用的还有在1990年12月11日授权Orr等人的美国专利4,976,953号中叙述的丙氧基丙三醇,此处整体引用作为参考。 Also useful are the propoxylated glycerol December 11, 1990 authorized Orr et al., US Patent No. 4,976,953 describes the overall incorporated herein by reference.

内相可非必选地含有水。 The internal phase may be optionally contains water. 只需要足够可以溶解水溶性调理剂的水。 Just enough to dissolve the water soluble conditioning agent. 通常,所需水的量依所需溶解的物质而定,例如其水中溶解度和流变性。 Typically, the amount of water required by the desired substances may be dissolved, such as water solubility and rheology. 因此,对于在加工的温度条件下是固体或非常粘稠的水溶性试剂来说,就需要较多的水,而对于在加工的温度条件下是液体或不很粘稠的水溶性调理剂来说,所需的水就较少。 Thus, for processing at a temperature in a solid or very viscous water soluble agents, it requires more water, at a temperature and for the processing is not very viscous liquid or water soluble conditioning agent He says there is less water needed. 类似地,在水中有较高溶解度的水溶性调理剂就比在水中溶解度较低的需要较少的水。 Similarly, a higher solubility in water soluble conditioning agent to lower solubility requires less water than in water.

内相中还可以非必选地包含其它水溶性或水分散性物质,这些物质不会不利地影响调理乳液的稳定性。 Required internal phase can optionally comprise other non water-soluble or water-dispersible substances which do not adversely affect the stability of the conditioning emulsion. 水溶性电解质就是一种这样的物质。 Water-soluble electrolyte is one such substance. 溶解的电解质可以最小化脂相中的物质也溶解到水相中的趋势。 The dissolved electrolyte can minimize the lipid phase materials are also dissolved in the aqueous phase trend. 任何可以产生对内相的离子强度的电解质都是适用的。 Any ionic strength of the electrolyte may be generated internal phase are applicable.

合适的电解质包括水溶性单、双或三价无机盐,例如水溶性碱金属或碱土金属的卤化物如氯化物、硝酸化物或硫酸化物。 Suitable electrolytes include the water soluble mono-, di-, or trivalent inorganic salts such as water soluble alkali metal halide or alkaline earth metals such as chlorides, nitric acid or sulfuric acid solvate thereof. 这样的电解质的例子包括氯化钠、氯化钙、硫酸钠、硫酸镁和碳酸氢钠。 Examples of such electrolytes include sodium chloride, calcium chloride, sodium sulfate, magnesium sulfate and sodium bicarbonate. 电解质的典型的浓度为内相的约1%至约20%。 Typically the concentration of the electrolyte phase is from about 1% to about 20%.

其它可以出现在内相中的水溶性或水分散性物质包括增稠剂和粘度改性剂。 Other water-soluble or water-dispersible material may occur in the internal phase include thickeners and viscosity modifiers. 适合的增稠剂和粘度改性剂包括水溶性聚丙烯酸系和疏水改性的聚丙烯酸系树脂,例如Carbopol和Pemulen,淀粉如玉米淀粉、马铃薯淀粉、木薯淀粉,树胶如瓜尔胶、阿拉伯胶,纤维素醚如羟丙基纤维素、羟乙基纤维素、羧甲基纤维素等。 Suitable thickeners and viscosity modifiers include water-soluble polyacrylic and hydrophobically modified polyacrylic resins such as Carbopol and Pemulen, starches such as corn starch, potato starch, tapioca, gums such as guar gum, gum arabic cellulose ethers such as hydroxypropyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose and the like. 这些增稠剂和粘度改性剂的典型的使用浓度为内相的约0.05%至约0.5%。 A typical use concentration of these thickeners and viscosity modifiers phase within about 0.05% to about 0.5%.

其它可以出现在内相中的水溶性或水分散性物质包括可以在水-脂界面提供空间稳定性的聚阳离子聚合物,和可以稳定脂包水乳液的非离子聚合物。 Other phases can occur, including water soluble or water dispersible material may include water - polycationic polymers to provide steric stabilization of the lipid interface and nonionic polymers water emulsions can be stabilized fat. 适合的聚阳离子聚合物包括Reten 201、Kymene557H和Acco 7112。 Suitable polycationic polymers include Reten 201, Kymene557H and Acco 7112. 适合的非离子聚合物包括聚乙二醇(PEG),如Carbowax。 Suitable nonionic polymers include polyethylene glycol (PEG), such as Carbowax. 这些聚阳离子和非离子聚合物的典型的使用浓度为内相的约0.1%至约1%。 Typical use concentrations of these polycationic and nonionic polymers as the internal phase from about 0.1% to about 1%.

乳化剂本发明产品的优选的实施方案包含可以形成内相-外相乳液的乳化剂。 Preferred embodiments of the present invention comprises an emulsifier product may be formed in the phase - emulsifier external phase of the emulsion. 在本发明的乳液中,包含有效量的乳化剂。 In the emulsion of the present invention, comprising an effective amount of emulsifier. “有效量”依据以下多因素而改变:油溶性试剂的量、所用乳化剂的类型、在乳化剂中杂质的量等。 An "effective amount" varies according to the following multiple factors: the amount of oil-soluble agent, the type of emulsifier used, the amount of impurities such as emulsifier. 典型地,乳化剂占调理乳液重量的约0.1%至约20%,优选约1%至约10%,更优选约3%至约6%。 From about 0.1% to about 20% Typically, the emulsifier accounts for conditioning emulsion weight, preferably from about 1% to about 10%, more preferably from about 3% to about 6%.

本发明使用的乳化剂典型地是油溶性或可混容于油溶性外相的物质,尤其是在脂类物质熔化的温度条件下。 Emulsifiers used in the present invention typically are oil soluble or miscible in the oil soluble external phase materials, especially at a temperature of the molten lipids. 其必须具有相对较低的HLB值。 It must have a relatively low HLB value. 适合在本发明中使用的乳化剂的HLB值的典型的范围为约1至约7,而且该乳化剂可以是不同乳化剂的混合物。 Suitable HLB value of the emulsifier used in the present invention typically ranges from about 1 to about 7, and the emulsifying agent may be a mixture of different emulsifiers. 优选地,这些乳化剂的HLB值为约1.5至约6,更优选为约2至约5。 Preferably, emulsifiers having an HLB value from about 1.5 to about 6, more preferably from about 2 to about 5.

有很多乳化剂可以在此使用,它们包括但不以此为限:脱水山梨醇酯、甘油酯、聚甘油酯、甲基葡萄糖酯、蔗糖酯、乙氧基化脂肪醇、氢化蓖麻油的乙氧基化物、脱水山梨醇酯的乙氧基化物、聚合的乳化剂和聚硅氧烷乳化剂。 There are many emulsifiers may be used herein, including, but not limited to: sorbitan esters, glycerol esters, polyglycerol esters, methyl glucose esters, sucrose esters, ethoxylated fatty alcohols, hydrogenated castor oil B alkoxylates, sorbitan ester ethoxylates, polymeric emulsifiers, and silicone emulsifiers.

脱水山梨醇酯适于本发明使用。 Sorbitan esters suitable for use herein. C16-C22的饱和的、不饱和的和支链脂肪酸的脱水山梨醇酯是优选的。 Saturated, unsaturated and branched chain fatty acids, sorbitan esters of C16-C22 are preferred. 根据其制造的方式,这些脱水山梨醇酯通常包含单、双、三酯的混合物。 The manner of its manufacture, these sorbitan esters usually comprise mixture of mono-, di-, tri- esters. 适合的脱水山梨醇酯的例子包括脱水山梨醇单油酸酯(例如SPAN 80)、脱水山梨醇倍半油酸酯(例如Arlacel 83)、脱水山梨醇单异硬脂酸酯(例如CRILL 6,Croda制造)、脱水山梨醇硬脂酸酯(例如SPAN60)、脱水山梨醇三油酸酯(例如SPAN 85)、脱水山梨醇三硬脂酸酯(例如SPAN 65)、脱水山梨醇二棕榈酸酯(例如SPAN40)和脱水山梨醇异硬脂酸酯。 Examples of suitable sorbitan esters include sorbitan monooleate (e.g. SPAN 80), sorbitan sesquioleate (e.g. Arlacel 83), sorbitan monoisostearate (e.g., CRILL  6, Croda Ltd.), sorbitan stearates (e.g. SPAN60), sorbitan trioleate (e.g. SPAN 85), sorbitan esters (e.g. SPAN 65) tristearate, sorbitan dipalmitate (e.g. SPAN40) and sorbitan isostearate. 在本发明中,脱水山梨醇单异硬脂酸酯和脱水山梨醇倍半油酸酯是尤其优选使用的乳化剂。 In the present invention, sorbitan monoisostearate and sorbitan sesquioleate are particularly preferred emulsifiers for use.

其它适合在本发明中使用的乳化剂包括,但不以此为限,甘油单酯,优选C16-C22的饱和、不饱和和支链的脂肪酸单甘油酯如甘油油酸酯、甘油单硬脂酸酯、甘油单棕榈酸酯、甘油单山萮酸酯,及其混合物;C16-C22的饱和、不饱和和支链的脂肪酸的聚甘油酯,如聚甘油-4异硬脂酸酯、聚甘油-3油酸酯、二甘油单油酸酯、四甘油单油酸酯,及其混合物;甲基葡糖酯,优选是C16-C22的饱和、不饱和和支链的脂肪酸的甲基葡糖酯,例如甲基葡糖二油酸酯、甲基葡糖倍半异硬脂酸酯,及其混合物;蔗糖脂肪酸酯,优选是C12-C22的饱和、不饱和和支链的脂肪酸的蔗糖酯,如蔗糖硬脂酸酯、蔗糖三月桂酸酯、蔗糖二硬脂酸酯(例如CrodestaF10),及其混合物;C12-C22乙氧基化脂肪醇,如oleth-2、oleath-3、steareth-2,及其混合物;氢化蓖麻油乙氧基化物,如PEG-7氢化蓖麻油;脱水山 Other suitable for use in the present invention, emulsifiers include, but not such as glyceryl oleate, glyceryl monostearate, fatty acid monoglycerides limit, monoglycerides, preferably C16-C22 saturated, unsaturated and branched esters, glyceryl monopalmitate, glyceryl monobehenate, and mixtures thereof; C16-C22 saturated, unsaturated and branched chain fatty acids, polyglycerol esters, such as polyglyceryl-4 isostearate, polyethylene glycerol-3 oleate, diglycerol monooleate, tetraglycerol monooleate, and mixtures thereof; methyl glucose esters, preferably the C16-C22 saturated, unsaturated and branched chain fatty acid methyl glucoside sugar esters, such as methyl glucose dioleate, methyl glucose sesqui-isostearate, and mixtures thereof; sucrose fatty acid esters, preferably the C12-C22 saturated, unsaturated and branched chain fatty acids sucrose esters such as sucrose stearate, sucrose trilaurate, sucrose distearate (e.g. CrodestaF10), and mixtures thereof; C12-C22 ethoxylated fatty alcohols such as oleth-2, oleath- 3, steareth-2, and mixtures thereof; hydrogenated castor oil ethoxylates such as PEG-7 hydrogenated castor oil; sorbitan 梨醇酯乙氧基化物,如PEG-40脱水山梨醇全油酸酯(peroleate)、Polysorbate-80,及其混合物;聚合物乳化剂,如乙氧基化十二烷基二醇共聚物;和聚硅氧烷乳化剂,如月桂基甲基聚硅氧烷共聚多元醇、鲸蜡基二甲聚硅氧烷、二甲聚硅氧烷共聚多元醇,及其混合物。 Sorbitol ester ethoxylates such as PEG-40 sorbitan oleate full (peroleate), Polysorbate-80, and mixtures thereof; polymeric emulsifiers, such as ethoxylated dodecyl glycol copolymer; and silicone emulsifiers such as sodium lauryl methicone copolyol, cetyl dimethicone, dimethicone copolyol, and mixtures thereof.

除了这些主要的乳化剂,本发明组合物还可非必选地包含共乳化剂以提供水-脂乳液稳定性。 In addition to these primary emulsifiers, the compositions of the present invention may also be optionally comprising an emulsifier to provide a water co - lipid emulsion stability. 适合的共乳化剂包括,但不以此为限,磷脂酰胆碱和含磷脂酰胆碱的组合物,例如卵磷脂;长链C16-C22脂肪酸盐,如硬脂酸钠;长链C16-C22二脂族基,短链C1-C4二脂族基季铵盐,如二动物脂基二甲基氯化铵和二动物脂基二甲基甲基硫酸铵;长链C16-C22二烷酰基(烯酰基)-2-羟乙基,短链C1-C4二脂族基季铵盐,如二动物脂酰基-2-羟乙基二甲基氯化铵;长链C16-C22二脂族基咪唑啉鎓季铵盐,如甲基-1-动物脂酰氨基乙基-2-动物脂咪唑啉鎓甲基硫酸盐和甲基-1-油基酰氨基乙基-2-油基咪唑啉鎓甲基硫酸盐;短链C1-C4二脂族基,长链C16-C22单脂族基苯甲基季铵盐,如二甲基硬脂基苯甲基氯化铵;和合成的磷脂,如硬脂酰氨丙基PG-dimonium氯化物(Mona Industries获得的磷脂PTS)。 Suitable coemulsifiers include, but not limited to, phosphatidyl choline and phosphatidyl choline-containing compositions such as lecithins; long chain C16-C22 fatty acid salts, such as sodium stearate; long chain C16 two -C22 aliphatic, short chain C1-C4 dialiphatic quaternary ammonium salts such as ditallow dimethyl ammonium chloride and ditallow dimethyl ammonium methyl sulfate; two long chain C16-C22 alkanoyl (alkenoyl) -2-hydroxyethyl, short chain C1-C4 dialiphatic quaternary ammonium salts such as ditallow dimethyl ammonium chloride-2-hydroxyethyl; two long chain C16-C22 aliphatic imidazolinium quaternary ammonium salts such as methyl-1-tallow amido ethyl-2-tallow imidazolinium methylsulfate and methyl-1-oleyl amido ethyl-2-oleyl imidazolinium methyl sulfate group; two short chain C1-C4 aliphatic, long chain C16-C22 monoaliphatic benzyl quaternary ammonium salts such as dimethyl stearyl benzyl ammonium chloride; and synthetic phospholipids such as stearamidopropyl PG-dimonium chloride propyl (phospholipid PTS Mona Industries obtained).

附加成分本发明产品可含有许多非必需成分。 Additional ingredients of the present invention may contain a number of non-essential product components. 其中一些在此详细列出。 Some of these are listed in detail. 特别适宜的为那些在清洁和调理过程中可对皮肤或毛发提供各种好处的各种活性成分。 Particularly suitable are those can provide various benefits to the skin or hair during the cleansing and conditioning of each active ingredient. 如果成分与调理乳液的内相或外相相容的话,这些成分就可以结合进合适的相内。 If the phase component and the external phase or conditioning emulsion are compatible, these ingredients can be incorporated into a suitable phase. 这对于水溶性活性成分尤其正确,这些水溶性活性成分与内相相容而不会引起调理乳液的不稳定。 This is especially true for water-soluble active ingredients, these water-soluble active ingredients are compatible with the internal phase without causing instability conditioning emulsion. 这些组合物中,产品适用于把活性成分传递到皮肤或毛发上。 In these compositions, the product is suitable for delivering an active ingredient to the skin or hair.

另外,上述描述调理乳液内相(水溶的)和外相(油溶的)的章节中描述的任何调理剂都可以与调理乳液分别加入基质中。 Further, the above described conditioning emulsion phase and an outer phase (water-soluble) (oil-soluble) any conditioning agents described in the section with the conditioning emulsion can be added to the matrix, respectively.

活性成份本发明的组合物含有安全和有效量的一种或多种活性成份及其药物上可接受的盐。 The composition of the active ingredient of the present invention comprise a safe and effective amount of one or more pharmaceutically active ingredients and pharmaceutically acceptable salts.

这里所用的“安全和有效量”一词,是指以在完善的药品评判的范围内的一个合理的活性组分的用量,该活性成份的量要足够高,以致于可以改善要处理的条件,或者可以给皮肤带来所期望的好处,但是又要使其足够低,以致于可以避免严重的副作用。 The term "safe and effective amount" as used herein, refers to a reasonable amount of active ingredient in the range of sound judgment of the drug, the amount of the active ingredient to be high enough so that the conditions to be treated can be improved or it can bring the desired benefits to the skin, but have to make it low enough so as to avoid serious side effects. 安全和有效量的活性成份的含义又将随着不同的活性物、活性物渗过皮肤的能力、使用者的年龄、健康状况以及皮肤条件和类似的其它因素而变化。 Meaning the ability to secure and effective amount of the active ingredient in turn with different active substance, the active substance seeps through the skin, the user's age, health and skin conditions and other factors like changes.

可以根据治疗作用和假设的作用模式给这里所用的活性物分类。 It may be used herein for active therapeutic and classified according to the assumed mode of action. 然而,应该明白的是这里所用的活性物有时可以提供不止一种治疗作用或者是可以执行多种作用形式。 However, it should be understood that the actives used herein can provide more than one therapeutic effect may or may perform the role of a variety of forms. 因此,为方便起见,这里进行了分类,但不是为了将活性物限制在列出的特定的一种应用或一些应用中。 Accordingly, for convenience, here we are classified, but are not intended to limit the active application specific one or some of the listed applications. 另外,这里也可以使用这些物质的药物上可接受的盐。 Further, these may be used herein pharmaceutically acceptable salts substance. 在本发明组合物中,下面的活性物是有用的。 In the compositions of the present invention, the following are useful activity.

抗痤疮活性物:有用的抗痤疮活性物的几个例子包括溶角蛋白剂,例如水杨酸(邻羟基苯甲酸)、水杨酸的衍生物例如5-辛酰水杨酸和间苯二酚;视黄酸类物质例如视黄酸和它的衍生物(例如顺式和反式视黄酸);含硫的D和L氨基酸及其衍生物和盐,尤其是其N-乙酰基衍生物,优选的例子为N-乙酰基-L-半胱氨酸;硫辛酸;抗菌素和灭菌剂例如过氧化苯甲酰、羟甲辛吡酮、四环素、2,4,4'-三氯-2'-羟基-二苯醚、3,4,4'-三氯对称二苯脲、壬二酸及其衍生物、苯氧基乙醇、苯氧基丙醇、苯氧基异丙醇、乙酸乙酯,氯林肯霉素和甲氯环素;sebostats例如类黄酮;胆汁盐例如鲨胆甾醇硫酸盐及其衍生物、脱氧胆酸盐和胆酸盐。 Anti-acne actives: Examples of useful anti-acne Several actives include keratolytic agents such as salicylic acid (o-hydroxybenzoic acid), derivatives of salicylic acid such as 5-octanoyl salicylic acid, and isophthalic phenol; retinoid substances such as retinoic acid and its derivatives (e.g., cis and trans retinoic acid); sulfur-containing D and L amino acids and their derivatives and salts, particularly their N- acetyl derivatives was preferred examples -L- is N- acetyl cysteine; lipoic acid; antibiotics and sterilizing agent such as benzoyl peroxide, octopirox, tetracycline, 2,4,4'-trichloro 2'-hydroxy - diphenyl ether, 3,4,4'-trichloro-symmetrical diphenylurea, azelaic acid and its derivatives, phenoxyethanol, phenoxy propanol, phenoxyisopropanol, ethyl acetate, clindamycin and meclocycline; sebostats e.g. flavonoids; bile salts such as shark cholesterol sulfate and its derivatives, deoxycholate and cholate.

抗皱和抗皮肤萎缩活性物:抗皱和抗皮肤萎缩活性物的几个例子包括视黄酸及其衍生物(顺式和反式);视黄醇、视黄酯、水杨酸及其衍生物;含硫的D和L氨基酸及其衍生物和盐,尤其是N-乙酰基衍生物,其优选的实例为N-乙酰基-L-半胱氨酸;硫醇,如乙硫醇;羟基酸,肌醇六磷酸,硫辛酸;溶血磷脂酸和去皮剂(例如苯酚);抗坏血酸及其衍生物。 Anti-wrinkle and anti-skin atrophy actives: examples of a few anti-wrinkle and anti-skin atrophy actives include retinoic acid and its derivatives (cis and trans); retinol, retinyl esters, salicylic acid and derivatives ; sulfur-containing D and L amino acids and their derivatives and salts, particularly N- acetyl derivatives, a preferred example thereof is N- acetyl -L- cysteine; mercaptans such as ethyl mercaptan; hydroxy acid, phytic acid, lipoic acid; lysophosphatidic acid, and peeling agents (e.g., phenol); ascorbic acid and derivatives thereof.

非甾族抗炎活性物(NSAIDS):NSAIDS的例子包括下列类型:丙酸衍生物、乙酸衍生物、灭酸衍生物、联苯基羧酸衍生物和oxicams。 Non-steroidal anti-inflammatory actives (NSAIDS): Examples of NSAIDS include the following types: propionic acid derivatives, acetic acid derivatives, fenamic acid derivatives, biphenylcarboxylic acid derivatives and oxicams. 所有这些NSAIDS都在1991年1月15日发表的Sunshine等人的美国专利4,985,459中有充分的说明,在这里作为参考。 All of these NSAIDS are fully described in there in January 15, 1991 issued US Patent 4,985,459 to Sunshine et al., Hereby incorporated by reference. 有用的NSAIDS的几个例子包括乙酰水杨酸、异丁苯丙酸、甲氧萘丙酸、苯噁丙芬、氟联苯丙酸、苯氧苯丙酸、联苯丁酮酸、酮苯丙酸、茚酮苯丙酸、吡丙芬、卡洛芬、噁哌拉嗪、双吡苯丙酸、咪洛芬、苯噁硫丙酸、噻丙吩、阿明洛芬、苯噻丙酸、氟苯丙酸和布氯酸。 Some examples of useful NSAIDS include acetyl salicylic acid, ibuprofen, naproxen, propyl benzene evil Finland, flurbiprofen, fenoprofen, fenbufen, phenyl ketone propionic acid, ketoprofen indene, pyrazole propionic Finland, carprofen, oxazine piperazine fluphenazine, pranoprofen, miroprofen, tioxaprofen, propyl thiophene thiophene, alminoprofen, tiaprofenic propyl acid, propionic acid and bucloxic acid fluorobenzene. 包括氢化可的松的甾族的抗炎药物也是有用的。 Including hydrocortisone steroidal anti-inflammatory drugs are also useful.

局部麻醉剂:几个局部麻醉剂的例子包括苯坐卡因、利度卡因、丁哌卡因、氯丙卡因、狄布卡因、衣铁卡因、甲哌卡因、丁卡因、达克罗宁、己卡因、普鲁卡因、可卡因、氯胺酮、丙吗卡因、苯酚和它们的药物上可以接受的盐。 Local anesthetics: Examples of topical anesthetic agents include several benzocaine, lidocaine, bupivacaine, ropivacaine chloropropyl, dibucaine, tetracaine clothes iron, mepivacaine, tetracaine, of Cronin, hexylcaine, procaine on cocaine, ketamine, pramoxine, phenol, and their pharmaceutically acceptable salts.

人工晒黑剂和晒黑促进剂:人工的用于晒黑的促进剂剂包括二羟基丙酮、酪氨酸、酪氨酸酯,如酪氨酸乙酯,和phospho-DOPA。 Artificial tanning agents and tanning accelerators: Artificial tanning agents accelerators include dihydroxyacetone, tyrosine, tyrosine esters such as ethyl tyrosine and phospho-DOPA is used.

抗菌和抗真菌活性物:抗菌和抗真菌活性物的例子有:β-内酰胺类药、喹诺酮类药物、环丙氟氯霉素、诺氟沙星、四环素、红霉素、阿米卡星、2,4,4'-三氯-2'-羟基二苯醚、3,4,4'-三氯对称二苯脲、苯氧基乙醇、苯氧基丙醇、苯氧基异丙醇、强力霉素、缠霉素、洗必汰、金霉素、土霉素、氯林肯霉素、乙氨丁醇、羟乙磺酸己脒定、甲哨唑、戊脒定、庆大霉素、卡那霉素、线霉素,甲烯土霉素、乌洛品托、二甲胺四环素、新霉素、奈替米星、巴龙霉素、链霉素、托普霉素、双氯苯咪唑、四环素、盐酸化物、红霉素、锌红霉素、无味红霉素、红霉素硬脂酸盐、硫酸阿米卡星、多西环素盐酸盐、硫酸卷曲霉素、葡萄糖酸洗必汰、盐酸洗必汰、盐酸金霉素、盐酸土霉素、盐酸氯林肯霉素、盐酸乙氨丁醇、盐酸甲哨唑、盐酸戊脒定、硫酸庆大霉素、硫酸卡 Antibacterial and antifungal actives: Examples of antimicrobial and antifungal actives include: the β- lactam drugs, quinolone drugs, cyclopropylmethyl fluoro chloramphenicol, norfloxacin, tetracycline, erythromycin, amikacin , 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichloro-symmetrical diphenyl urea, phenoxyethanol, phenoxy propanol, phenoxyisopropanol , doxycycline, wrapped neomycin, chlorhexidine and eliminating, chlortetracycline, oxytetracycline, clindamycin, ethylamino butanol, hexamidine isethionate, metronidazole, pentamidine given, gentamicin Su, kanamycin, neomycin line, methacycline, Wuluo Pinto, minocycline, neomycin, netilmicin, paromomycin, streptomycin, tobramycin, miconazole, tetracycline hydrochloride, erythromycin, zinc erythromycin, erythromycin estolate, erythromycin stearate, amikacin sulfate, doxycycline hydrochloride, capreomycin sulfate glucose elimination will pickling, eliminating chlorhexidine hydrochloride, chlortetracycline hydrochloride, oxytetracycline hydrochloride, clindamycin hydrochloride chloride, ammonium acetate, butanol hydrochloride, oxazole hydrochloride A post, given pentamidine hydrochloride, gentamicin sulfate, sulfuric acid card 霉素、盐酸线霉素、盐酸甲烯土霉素、马尿酸乌洛托品、扁桃酸乌洛托品、盐酸二甲胺四环素、硫酸新霉素、硫酸奈替米星、硫酸巴龙霉素、硫酸链霉素、硫酸托普霉素、盐酸双氯苯咪唑、盐酸amanfadine、硫酸amanfadine、羟甲辛吡酮、对氯间二甲苯酚、制霉菌素、癣退、2-巯基吡啶氧化锌和克霉唑。 Minocycline, neomycin, line hyclate, methacycline hydrochloride, methenamine hippurate, methenamine, methenamine mandelate acid, hydrochloric acid, neomycin sulfate, Chennai etimicin sulfate, mycophenolic acid Baron Su, miconazole streptomycin sulfate, tobramycin sulfate, neomycin, imidazole hydrochloride, amanfadine hydrochloride, amanfadine sulfate, octopirox, parachlorometa xylenol, nystatin, tolnaftate, 2-mercaptopyridine oxide zinc and clotrimazole.

这里有用的几个优选的活性物的例子包括水杨酸、过氧化苯甲酰、3-羟基苯甲酸、4-羟基苯甲酸、乙酰基水杨酸、2-羟基丁酸、2-羟基戊酸、2-羟基己酸、顺-视黄酸、反-视黄酸、视黄醇、肌醇六磷酸、抗坏血酸及其衍生物、N-乙酰基-L-半胱氨酸、硫辛酸、壬二酸、花生四烯酸、过氧化苯甲酸、四环素、异丁苯丙酸、甲氧萘丙酸、氢化可的松、acetominophen、间苯二酚、苯氧基乙醇、苯氧基丙醇、苯氧基异丙醇、2,4,4'-三氯-2'-羟基二苯醚、3,4,4'-三氯对称二苯脲、羟甲辛吡酮、利度卡因盐酸盐、克霉唑、双氯苯咪唑、硫酸neocycin、和它们的混合物。 Examples of useful herein several preferred actives include salicylic acid, benzoyl peroxide, 3-hydroxybenzoic acid, 4-hydroxybenzoic acid, acetylsalicylic acid, 2-hydroxybutyric acid, 2-hydroxy-pentyl acid, 2-hydroxycaproic acid, cis - retinoic acid, trans - retinoic acid, retinol, phytic acid, ascorbic acid and derivatives thereof, N- acetyl -L- cysteine, lipoic acid, azelaic acid, arachidonic acid, peroxybenzoic acid, tetracycline, ibuprofen, naproxen, hydrocortisone, acetominophen, resorcinol, phenoxyethanol, phenoxypropanol , phenoxyisopropanol, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichloro-symmetrical diphenylurea, octopirox, lidocaine hydrochloride, clotrimazole, miconazole, neocycin sulfate, and mixtures thereof.

防晒活性物:在这里某些防晒剂是有用的。 Sunscreen actives: Here are some useful sunscreens. 各种各样的防晒剂在下列文献中都有说明:1992年2月11日授权的Haffey等人的美国专利No.5,087,445;1991年12月17日授权的Turner等人的美国专利No.5,073,372;1991年12月17日授权的Turner等人的美国专利No.5,073,371;Segarin等人的化妆品科学与技术一书中第八章第189页。 A wide variety of sunscreens are described in the following documents: February 11, 1992 authorized Haffey, et al., US Patent No.5,087,445; 1991 Nian 12 Yue 17, issued Turner et al, US Patent No.5,073,372 ; December 17, 1991 authorized Turner et al., US Patent No.5,073,371; Segarin et al cosmetic Science and technology Chapter VIII of the book on page 189. 所有上述文献全文在这里都全文作为参考。 All of the above documents are hereby entirety herein by reference. 用于本发明的这些防晒剂的非限制性实例选自对甲氧基肉桂酸(2-乙基-己)酯、N,N-二甲基-对氨基苯甲酸(2-乙基己)酯、对氨基苯甲酸、2-苯基苯并咪唑-5-磺酸、奥克立林、羟苯甲酮、水杨酸高酯、水杨酸辛酯、4,4'-甲氧基-叔丁基二苯甲酰基甲烷、4-异丙基二苯甲酰基甲烷、3-亚苄基樟脑、3-(4-甲基亚苯基)樟脑、二氧化钛、氧化锌、二氧化硅、氧化铁及其混合物。 Non-limiting examples of these sunscreen agents of the present invention is selected from p-methoxy cinnamic acid (2-ethyl - hexyl) ester, N, N- dimethyl - p-aminobenzoic acid (2-ethylhexyl) ester, p-aminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid, octocrylene, oxybenzone, salicylate high  salicylate, octyl salicylate, 4,4'-methoxy - tert-butyl-dibenzoylmethane, 4-isopropyl dibenzoylmethane, 3-benzylidene camphor, 3- (4-phenylene) camphor, titanium dioxide, zinc oxide, silicon dioxide, iron oxide and mixtures thereof. 其它一些有用的防晒剂公开于1990年6月26日授权Sabatelli的USP4937370;1991年3月12日授权Sabatelli等人的USP4999186;这两篇都结合入供参考。 Other useful sunscreens disclosed on June 26, 1990 the authorized Sabatelli USP4937370; 1991 years. 3 dated 12 is Sabatelli et al., Issued USP4999186; both of which are incorporated by reference. 这些实例中尤其优选2,4-二羟基二苯酮的4-N,N-(2-乙基己基)甲基氨基苯甲酸酯、4-羟基二苯甲酰基甲烷的4-N,N-(2-乙基己基)甲基氨基苯甲酸酯、2-羟基-4-(2-羟基乙氧基)二苯酮的4-N,N-(2-乙基己基)甲基氨基苯甲酸酯、4-(2-羟基乙氧基)二苯甲酰基甲烷的4-N,N-(2-乙基己基)甲基氨基苯甲酸酯、及其混合物。 These examples in particular 2,4-dihydroxybenzophenone preferably 4-N, N- (2- ethylhexyl) methyl-aminobenzoic acid ester, 4-hydroxy dibenzoyl methane, 4-N, N - (2-ethylhexyl) methyl aminobenzoic acid ester of 2-hydroxy-4- (2-hydroxyethoxy) benzophenone, the 4-N, N- (2- ethylhexyl) methylamino benzoate, 4- (2-hydroxyethoxy) dibenzoyl methane, 4-N, N- (2- ethylhexyl) methyl-aminobenzoic acid esters, and mixtures thereof. 防晒剂的确切的使用量取决于所选防晒剂和所需的防晒因子(SPF)。 The exact amount of sunscreen depends on the selected sunscreen and the desired Sun Protection Factor (SPF). SPF是防晒剂防止起红斑的光保护作用的常用量度方法。 SPF is a commonly used measure to prevent play method sunscreen photoprotection of erythema. 见Federal Register,卷43,No.166,第38206-38269页,8月25,1978,引入本文供参考。 See Federal Register, Volume 43, No.166, pp. 38206-38269, August 25,1978, incorporated herein by reference.

在这里有用的优选的活性物的非限制性例子包括水杨酸、过氧化苯甲酰、顺-视黄酸、反-视黄酸、视黄醇、棕榈酸视黄酯、抗坏血酸、肌醇六磷酸、N-乙酰基-L-半胱氨酸、壬二酸、硫辛酸、间苯二酚、异丁苯丙酸、甲氧萘丙酸、氢化可的松、苯氧基乙醇、苯氧基丙醇、苯氧基异丙醇、2,4,4'-三氯-2'-羟基二苯醚、3,4,4'-三氯对称二苯脲、对甲氧基肉桂酸2-(乙基己)酯、羟苯甲酮、2-苯基苯并咪唑-5-磺酸、二羟基丙酮和它们的混合物。 Useful non-limiting examples of preferred actives herein include salicylic acid, benzoyl peroxide, cis - retinoic acid, trans - retinoic acid, retinol, retinyl palmitate, ascorbic acid, inositol phytic acid, N- acetyl -L- cysteine, azelaic acid, lipoic acid, resorcinol, ibuprofen, naproxen, hydrocortisone, phenoxyethanol, benzyl group propanol, phenoxyisopropanol, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichloro-symmetrical diphenyl urea, p-methoxy cinnamic acid (2-ethyl hexyl) acrylate, oxybenzone, 2-phenylbenzimidazole-5-sulfonic acid, dihydroxyacetone, and mixtures thereof.

阳离子表面活性剂本发明的产品还可以非必须地包含一种或多种阳离子表面活性剂,只要选取的这些物质不干扰所需的起泡型表面活性剂的整体起泡性能。 Product cationic surfactants of the present invention can also optionally comprise one or more cationic surfactants, provided these materials do not interfere with the selected overall lather performance lathering surfactant is required.

用于本发明组合物中的阳离子表面活性剂的非限制性实例公开于McCutcheon的洗涤剂与乳化剂,北美版(1986),AlluredPublishing Corporation出版;和McCutcheon的功能物质,北美版(1992);两文献都全部引入作为参考。 Non-limiting examples of cationic surfactants in compositions of the present invention, active agents are disclosed in McCutcheon's Detergents and Emulsifiers, North American Edition (1986), AlluredPublishing Corporation publication; and McCutcheon's, Functional Materials, North American Edition (1992); two all documents are incorporated by reference.

这里有用的阳离子表面活性剂的非限制性实例包括有下列分子式的阳离子铵盐: Non-limiting examples of useful cationic surfactants herein include cationic ammonium salts have the formula: 其中,R1选自含有大约12~18个碳原子的烷基,或者含有大约12~18个碳原子的芳族基、芳基或烷芳基;R2、R3和R4要各自从氢、含有大约1~18个碳原子的烷基或者含有大约12~18个碳原子的芳族基、芳基或烷芳基中选择;X是从由氯、溴、碘、乙酸根、磷酸根、硝酸根、硫酸根、甲基硫酸根、乙基硫酸根、甲苯磺酸根、乳酸根、柠檬酸根、甘醇酸根以及它们的混合物构成的集合中选择。 Wherein, Rl is selected from an alkyl group containing from about 12 to 18 carbon atoms or containing from about 12 to 18 carbon atoms, an aromatic group, an aryl group or alkaryl group; R2, R3 and R4 are each selected from hydrogen to be contained approximately an alkyl group having 1 to 18 carbon atoms or from about 12 to 18 carbon atoms, an aromatic group, an aryl group or alkaryl group selection; X is from the group consisting of chlorine, bromine, iodide, acetate, phosphate, nitrate , sulfate, methyl sulfate, ethyl sulfate, tosylate, lactate, citrate, glycolate, and mixtures thereof set configuration selected. 另外,烷基也可以含有醚键,或者羟基或氨基取代基(例如,烷基可以含有聚乙二醇和聚丙二醇部分)。 Further, alkyl groups may contain ether linkages, or hydroxy or amino group substituents (e.g., alkyl groups can contain polyethylene glycol and polypropylene glycol portion).

更优选的是,R1是一个含有大约12~18个碳原子的烷基;R2从H或含有大约1~18个碳原子的烷基中选择;R3和R4从氢、含有大约1~3个碳原子烷基中选取;X则如前所述。 And more preferably, Rl is an alkyl group containing from about 12 to 18 carbon atoms; R2 selected from H or an alkyl group containing from about 1 to 18 carbon atoms; R3 and R4 are selected from hydrogen, containing from about 1 to 3 alkyl group carbon atoms selected; X-is as previously described.

最优选的是,R1是一个含有大约12~18个碳原子的烷基;R2、R3和R4从氢、含有大约1~3个碳原子烷基中选择;X则如前所述。 Most preferably, Rl is an alkyl group containing from about 12 to 18 carbon atoms; R2, R3 and R4 are selected from hydrogen, alkyl groups containing carbon atoms, selected from about 1 to 3; X-is as previously described.

作为一个替代的办法,其它有用的阳离子乳化剂包括氨基酰胺,其中上述的结构中R1替换为R5CO-(CH2)n-,其中R5是含有大约12~22个碳原子的烷基,n是大约2~6的一个整数,优选的是大约2~4的一个整数,更优选的是大约2~3的一个整数。 As an alternative approach, other useful cationic emulsifiers include amino-amides, wherein in the above structure R1 is alternatively R5CO- (CH2) n-, wherein R5 is an alkyl group containing from about 12 to 22 carbon atoms, n is about an integer from 2 to 6, preferably an integer from about 2 to about 4, and more preferably an integer from about 2 to 3. 非限制性的这些阳离子乳化剂包括硬脂酰氨基丙基氯化磷酸PG-dimonium,硬脂酰氨基丙基硫酸二乙酯乙基dimonium,硬脂酰氨基丙基二甲基(十四烷基乙酸)氯化铵,硬脂酰氨基丙基二甲基cetearyl甲苯磺酸铵,硬脂酰氨基丙基二甲基氯化铵、硬脂酰氨基丙基二甲基乳酸铵以及它们的混合物。 Non-limiting these cationic emulsifiers include stearyl amidopropyl acid chloride, PG-dimonium, stearyl amidopropyl diethyl sulfate, ethyl dimonium, stearyl amidopropyl dimethyl (tetradecyl acetate) ammonium chloride, stearyl amidopropyl dimethyl cetearyl ammonium tosylate, stearyl amidopropyl dimethyl ammonium chloride, stearyl amidopropyl dimethyl ammonium lactate, and mixtures thereof.

非限制性的季铵盐阳离子乳化剂几个例子可以是从由十六烷基氯化铵、十六烷基溴化铵、十二烷基氯化铵、十二烷基溴化铵、硬脂基氯化铵、硬脂基溴化铵、十六烷基二甲基氯化铵、十六烷基二甲基溴化铵、十二烷基二甲基氯化铵、十二烷基二甲基溴化铵、硬脂基二甲基氯化铵、硬脂基二甲基溴化铵、十六烷基三甲基氯化铵、十六烷基三甲基溴化铵、十二烷基三甲基氯化铵、十二烷基三甲基溴化铵、硬脂基三甲基氯化铵、硬脂基三甲基溴化铵、十二烷基二甲基氯化铵、硬脂基二甲基十六烷基二动物脂基二甲基氯化铵、二-十六烷基氯化铵、二-十六烷基溴化铵、二-十二烷基氯化铵、二-十二烷基溴化铵、二硬脂基氯化铵、二硬脂基溴化铵、二-十六烷基甲基氯化铵、二-十六烷基甲基溴化铵、二-十二烷基甲基氯化铵、二-十二烷基甲基溴化铵、二硬脂基 Non-limiting examples of quaternary ammonium salt cationic emulsifiers may be several from the group consisting of cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, hard aliphatic ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, dodecyl dimethyl ammonium chloride, lauryl dimethyl ammonium bromide, ammonium bromide, stearyl dimethyl ammonium chloride, stearyl, cetyl trimethyl ammonium chloride, cetyl trimethyl ammonium bromide, ten dialkyl trimethyl ammonium chloride, dodecyl trimethyl ammonium bromide, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, lauryl dimethyl dichloride ammonium, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, di - hexadecyl ammonium chloride, di - cetyl ammonium bromide, di - dodecyl chloride ammonium, di - dodecyl ammonium bromide, distearyl ammonium chloride, distearyl ammonium bromide, di - cetyl dimethyl ammonium chloride, di - cetyl bromide ammonium, di - dodecyl dimethyl ammonium chloride, di - dodecyl ammonium bromide, distearyl 基氯化铵、二硬脂基二甲基氯化铵、二硬脂基甲基溴化铵以及它们的混合物构成的集合中选择的那些例子。 Ammonium chloride, distearyl those examples set dimethyl ammonium chloride, distearyl ammonium bromide, and mixtures thereof selected configuration. 其它的的季铵盐包括那些其中C12-C22烷基碳链是由动物脂脂肪酸或椰油脂肪酸衍生的。 Other quaternary ammonium salts include those wherein the C12-C22 alkyl carbon chain is derived from tallow fatty acid or coconut fatty acid-derived. 其中“动物脂基”一词是指一个由通常含C16~C18范围内的烷基的混合物的动物脂肪酸衍生的烷基(通常是加氢的动物脂肪酸),而“椰油”一词是指由通常含C12-C14的烷基链混合物的椰油脂肪酸衍生的一个烷基。 Wherein "tallow" refers to a generally derived from tallow fatty alkyl group containing in the range of C16 ~ C18 mixture of alkyl (usually hydrogenated tallow fatty acid), and the "coco" refers to alkyl group derived from a coconut fatty alkyl chains generally contain a mixture of C12-C14. 由这些动物脂和椰油得到的几个季铵盐的例子包括二动物脂基二甲基氯化铵,二动物脂基二甲基甲基硫酸铵、二(加氢动物脂基)二甲基氯化铵、二(加氢动物脂)二甲基醋酸铵、二动物脂二甲基磷酸铵、二动物脂二甲基硝酸铵、二(椰油烷基)二甲基氯化铵、二(椰油烷基)二甲基溴化铵、动物脂氯化铵、椰油基氯化铵、硬脂酰氨基丙基酸PG-dimonium、硬脂酰氨基丙基硫酸二乙酯乙基dimonium、硬脂酰氨基丙基二甲基(十四烷基乙酸)氯化铵,硬脂酰氨基丙基二甲基cetearyl甲苯磺酸铵、硬脂酰氨基丙基二甲基氯化铵、硬脂酰氨基丙基二甲基乳酸铵以及它们的混合物构成的集合中选择。 Several examples of such a quaternary ammonium salt of tallow and coconut derived include ditallow dimethyl ammonium chloride, ditallow dimethyl ammonium methyl sulfate, di (hydrogenated tallow) dimethyl ammonium chloride, di (hydrogenated tallow) dimethyl ammonium acetate, ditallow dimethyl ammonium, ditallow dimethyl ammonium nitrate, di (coconut alkyl) dimethyl ammonium chloride, di (coconut alkyl) dimethyl ammonium bromide, tallow ammonium chloride, coconut ammonium chloride, stearyl amidopropyl acid PG-dimonium, stearyl amido ethyl-propyl diethyl sulfate dimonium, stearyl amidopropyl dimethyl (myristyl acetate) ammonium chloride, stearyl amidopropyl dimethyl cetearyl ammonium tosylate, stearyl amidopropyl dimethyl ammonium chloride, selecting a set of stearyl amidopropyl dimethyl ammonium lactate, and mixtures thereof constituted.

优选的阳离子表面活性物可以从由二-十二烷基二甲基氯化铵、二-硬脂基二甲基氯化铵、二-十四烷基二甲基氯化铵、二-十六烷基二甲基氯化铵及其混合物构成的集合中选择。 Preferred cationic surfactants may be from a two - dodecyl dimethyl ammonium chloride, di - distearyl dimethyl ammonium chloride, di - tetradecyl dimethyl ammonium chloride, di - ten selecting a set of six alkyl dimethyl ammonium chloride and mixtures thereof in.

其它非必需组分本发明的组合物可以含多种其它非必需组分。 Other non-essential components of the invention compositions may contain a variety of other optional components. 这些其它组分是药物上可接受的。 These other components are pharmaceutically acceptable. 在本文中被完全引用作为参考的CTFA化妆品成分手册,第2版,1992中,描述了许多种常用于护肤品工业的非限制性化妆品和药品级组分,这些组分适用于本发明的组合物。 Are fully incorporated by reference in CTFA Cosmetic Ingredient Handbook, Second Edition, 1992, describes a wide variety commonly used in the skin care industry, nonlimiting cosmetic and pharmaceutical grade components which is useful in the compositions of the present invention herein thereof. 在该参考内容的第537页描述了一些功能类组分的非限制性的例子。 Non-limiting examples of functional classes of components in the content page 537 of this reference is described. 这些和其它的功能类的实例包括:磨料,吸收剂,防结块剂,抗氧化剂,维生素,粘合剂,生物添加剂,缓冲剂,填充剂,螯合剂,化学添加剂,着色剂,化妆品收敛剂,化妆品生物杀伤剂,变性剂,药物收敛剂,外用止痛剂,成膜剂,香料组分,湿润剂,遮光剂,pH调理剂,防腐剂,推进剂,还原剂,皮肤增白剂和防晒剂。 Examples of these and other functional classes include: abrasives, absorbents, anticaking agents, antioxidants, vitamins, binders, biological additives, buffering agents, bulking agents, chelating agents, chemical additives, colorants, cosmetic astringents , cosmetic biocides, denaturants, drug astringents, external analgesics, film formers, fragrance components, humectants, opacifying agents, pH conditioners, preservatives, propellants, reducing agents, skin lightening agents and sunscreen agents.

这里也可以使用美感组分,例如香料,色素,着色剂,芳香油,皮肤致敏剂(skin sensate),收敛剂,皮肤舒适剂,皮肤愈合剂。 It may be used herein aesthetic components such as fragrances, pigments, colorants, perfume oils, skin sensitizers (skin sensate), astringents, skin comfort agents, skin healing agents.

制造方法本发明的可自由使用的一次性个人护理清洁和调理产品通过分别或同时把起泡型表面活性剂和调理剂加入到水不溶性基质上或浸渍在其中而制造,所得的产品基本上是干燥的。 Disposable personal care cleansing and conditioning product may be used freely by the manufacturing method of the present invention separately or simultaneously the lathering surfactants and the conditioning agents added to the water-insoluble matrix or impregnated therein produced, the resulting product is substantially dry. “分别”是指表面活性剂和调理剂在最初没有混合,可以按任何次序依次加入。 ", Respectively," refers to a surfactant and conditioning agents are not mixed in the first, can be added sequentially in any order. “同时”是指表面活性剂和调理剂在最初混合或没有混合时,同时加入。 "Simultaneous" refers to surfactants and conditioning agents in the initial mixing or no mixing, add.

例如,可首先把起泡型表面活性剂加入到水不溶性基质上或浸渍在其中,随后加入调理剂,或反过来。 For example, the first lathering surfactant is added to the water-insoluble matrix or impregnated therein, followed by addition of conditioning agents, or vice versa. 此外,可把起泡型表面活性剂和调理乳液同时加入到水不溶性基质上或浸渍在其中。 Further, the lathering surfactant and the conditioning emulsion was simultaneously added to a water-insoluble matrix or impregnated therein.

表面活性剂、调理剂和任何非必需成分可以用任何本领域有技能的人所熟知的方法加入到水不溶性基质上或浸渍在其中:例如通过喷涂、移印、喷洒、浸渍、浸泡或涂层方法。 Surfactants, conditioning agents, and any optional ingredients can be present in any method of the art the person skilled in the art is added to the water-insoluble matrix or impregnated therein: for example by spraying, pad printing, spraying, dipping, soaking or coating method. 非必选的成分可以与调理乳液的内相或外相中的那些成分相同。 The ingredients may be optionally conditioning emulsion phase within the external phase or the same components as those of.

根据本发明制备产品时,先制备调理乳液。 When producing a product of the invention, first prepared conditioning emulsion. 典型地,通过将油溶性外相组分和乳化剂混合或熔化在一起来获得。 Typically, the external phase components and oil-soluble emulsifier or melt together to obtain. 这些油溶性试剂/乳化剂混合物加热的温度依据油溶性外相组分的熔点而定。 These oil-soluble agents / emulsifier mixture is heated to a temperature based on the melting point of the oil soluble external phase component depends. 典型地,在混合、共混或与水溶性内相组分以其它方式结合前,将这些油溶性试剂/乳化剂混合物加热到约60℃至约90℃,优选为约70℃至约80℃。 Typically, in the mixing, blending or before the water-soluble component in combination with other ways, these oil soluble agents / emulsifier mixture is heated to about 60 deg.] C to about 90 ℃, preferably from about 70 deg.] C to about 80 deg.] C . 但是,在形成调理乳液时,不是总是需要加热的。 However, in the formation of emulsions conditioning, heating is not always required. 熔化的油溶性试剂/乳化剂混合物然后与水相组分一起共混,以制备乳液。 Melting oil soluble agent / emulsifier mixture is then blended together with an aqueous phase component, to prepare an emulsion.

生产过程中用到水或湿气时,最终处理过的基质要干燥以使其基本上不含水。 When used in the production process of water or moisture, the final treated substrate so as to be substantially free of water and dried. 处理过的基质可以用本领域有技能的人所熟知的任何方法干燥。 The treated substrate can be by any method known to persons skilled in the art dried. 熟知的干燥方法的非限制性例子有使用对流烘箱、辐射热源、微波炉、鼓风炉和加热滚筒或加热罐。 Non-limiting examples of known drying processes using convection ovens are, radiant heat sources, microwave ovens, and heated rollers or blast furnace heating tank. 还有不需加入除了在周围环境中的热能的风干。 There is no need to add in addition to air-dry in the heat of the surrounding environment. 同样,可以一同使用各种干燥方法。 Similarly, various drying methods may be used together.

清洁和调理皮肤或毛发的方法本发明还介绍了用本发明的个人清洁产品清洁和调理皮肤或毛发的方法。 The method of cleansing and conditioning the skin or hair of the present invention also describes a method for personal cleansing products cleansing and conditioning the skin or hair of the present invention. 这些方法是,把含有水不溶性基质、起泡型表面活性剂、调理成分的基本上干燥的可自由使用的一次性个人清洁产品用水润湿,并把润湿的产品与皮肤或毛发接触。 These methods, comprising the water-insoluble substrate a lathering surfactant, substantially dry disposable personal cleansing product can be used freely conditioning component is moistened with water, and the moistened products are contacted with the skin or hair. 在另外的实施方案中,本发明还适用于把各种活性成分传递到皮肤或毛发上。 In a further embodiment, the present invention is also applicable to the delivery of each active ingredient to the skin or hair.

本发明的产品基本上为干燥的,在使用前用水润湿。 The product of the present invention is substantially dry, wet with water before use. 通过把产品浸渍在水中或将其放置在水流中,使之润湿。 By immersing the product in water or placed in water and allowed to wet. 通过在产品与皮肤或毛发接触前或接触中机械搅动产品和/或使其变形,可以从产品中产生泡沫。 Mechanical agitation by contacting the product and / or deform, can produce a foam product from the product prior to or in contact with the skin or hair. 产生的泡沫可用于清洁和调理皮肤或毛发。 Bubble generation can be used for cleansing and conditioning the skin or hair. 在清洁过程以及随后的用水清洗过程中,调理剂和活性成分沉积在皮肤或毛发上。 During the cleaning process and the subsequent washing with water, the conditioning agents and active ingredients are deposited on the skin or hair. 通过基质与皮肤或毛发的实际接触,可增强调理剂和活性成分的沉积。 By actually contacting the substrate with the skin or hair, deposition of conditioning agents can be enhanced, and the active ingredient.

调理组分在皮肤或毛发上的沉积本发明的组合物适用于把本发明的调理组分沉积到皮肤或毛发上。 The conditioning component of the present invention composition is deposited on the skin or hair conditioning component suitable for the present invention is deposited onto the skin or hair. 在另外的含有活性成分的实施方案中,组合物也适用于把活性成分沉积到皮肤或毛发上。 In further embodiments, containing the active ingredient, the compositions also apply to the deposition of active ingredients onto the skin or hair.

在产品的使用中,本发明的组合物优选地把大于约2.5微克/厘米2,更优选地大于约5微克/厘米2,更优选地大于约10微克/厘米2,最优选地大于约25微克/厘米2的调理组分沉积到皮肤或毛发上。 In use of the product, the compositions of the present invention is preferably to greater than about 2.5 micrograms / cm2, more preferably greater than about 5 micrograms / cm2, more preferably greater than about 10 micrograms / cm 2, most preferably greater than about 25 conditioning component [mu] g / cm 2 is deposited onto the skin or hair.

本发明还介绍了把调理组分沉积到皮肤或毛发表面的方法,把大于约2.5微克/厘米2,优选地大于约5微克/厘米2,更优选地大于约10微克/厘米2,最优选地大于约25微克/厘米2的调理组分沉积到皮肤或毛发上。 The present invention also describes the conditioning component deposited onto the surface of a skin or hair, to greater than about 2.5 micrograms / cm 2, preferably greater than about 5 micrograms / cm2, more preferably greater than about 10 micrograms / cm 2, most preferably greater than about 25 micrograms / cm 2 of the conditioning component deposited on the skin or hair.

可以用本领域具有一般技能的化学工作者熟知的各种标准分析方法测定沉积在皮肤或毛发上的调理成分的量。 Various standard analytical methods may have chemists of ordinary skill in the art well known assay is deposited on the skin or hair conditioning amount of the composition. 这些方法有,例如用适当的溶剂从一定面积的皮肤或毛发中提取物质,随后用色谱法(即气相色谱法、液相色谱法、超临界流体色谱法等)、红外光谱法、紫外/可见光谱法、质谱法等方法分析。 These methods are, for example extracting a substance from a certain area of ​​the skin or hair with a suitable solvent, followed by chromatography (i.e. gas chromatography, liquid chromatography, supercritical fluid chromatography, etc.), IR spectroscopy, UV / VIS spectral analysis, mass spectrometry and the like. 也可用红外光谱法、紫外/可见光谱法、浊度测量法、荧光光谱法、电子光谱法等方法,直接在皮肤或毛发上进行测定。 The method may also be infrared spectroscopy, UV / VIS spectroscopy, turbidity measurements, fluorescence spectroscopy, electron spectroscopy and the like, is measured directly on the skin or hair.

在测定沉积量的一个典型方法中,把本发明的产品用水润湿并挤压搅动,以产生泡沫。 In a typical method for measuring deposition amount, the product of the present invention is wetted with water and squeezed agitated to generate foam. 然后把产品在皮肤或头上用适当的不易消除的记号定界的约25平方厘米到约300平方厘米,优选地约50平方厘米到约100平方厘米的区域内摩擦约15秒。 Then the product in the skin or the head with an appropriate symbol of the delimitation easy to eliminate from about 25 cm2 to about 300 cm2, preferably from about 50 cm2 to the friction in the region of about 100 cm to about 15 seconds. 然后把该区域清洗约10秒,随后使其风干约10分钟。 The area is then cleaned for about 10 seconds, then allowed to air dry for about 10 minutes. 然后从该区域提取并分析提取物,或用以上例举的任何方法直接分析。 Then extracted from this region and the extracts analyzed, or analyzed directly using any of the methods exemplified above.

实施例以下的实施例进一步描述并例证了本发明范围内的实施方案。 Examples The following examples further describe embodiments and illustrative embodiments within the scope of the invention. 以下的实施例中,所有的成分都以活性含量列出。 The following examples, all ingredients are listed at an active content. 只是为了例证的目的给出这些实例,不应理解为本发明的限制,因为在不违背本发明的精神和范围的前提下,可能有很多变化。 We are given for purposes of illustration only these examples should not be construed to limit the present invention, since without departing from the spirit and scope of the present invention, there may be many variations.

成分名称以化学名称或CTFA命名给出,所有的重量都是以活性物的百分比计。 Component name given chemical name or CTFA name, all weight percentages are based on the active basis.

I.表面活性剂相在一合适的容器内,在室温条件下混合下列成分。 I. surfactant phase in a suitable vessel, mix the following ingredients at room temperature. 一旦聚季铵盐得到分散后,将混合物加热到65℃。 Once the polyquaternium is dispersed, and the mixture was heated to 65 ℃.

成分 重量百分比实施例1 实施例2 实施例3 实施例4 实施例5水 足量至 足量至 足量至 足量至 足量至100 100 100 100 100聚季铵盐-10 0.25 0.25 0.25 0.25 0.25当上述混合物加热到65℃后,加入下列成分。 Percentage of weight Example 1 Example 2 Example 3 Example 4 Example 5 Water qs to embodiments q.s. q.s. q.s. q.s. 100,100,100,100,100 Polyquaternium-10 0.25 0.25 0.25 0.25 0.25 after heating the mixture to 65 ℃, the following ingredients were added.

EDTA二钠 0.10 0.10 0.10 0.10 -月桂基醚硫酸铵 4.20 4.20 4.20 4.20 -月桂基硫酸铵 1.40 1.40 1.40 1.40 -月桂两性乙酸钠 2.40 2.40 2.40 2.40 -月桂酰基肌氨酸钠 - - - - 4.00 Disodium EDTA 0.10 0.10 0.10 0.10 - lauryl ether sulphate 4.20 4.20 4.20 4.20 - 1.40 1.40 Ammonium Lauryl Sulfate 1.40 1.40 - 2.40 2.40 sodium acetate, lauryl amphoteric 2.40 2.40 - Sodium lauroyl sarcosinate - - - - 4.00

月桂两性二乙酸二钠和十三烷 - - - - 4.00基醚硫酸钠当上述成分完全混合后,开始将混合物冷却至45℃。 And amphoteric disodium lauryl tridecyl - - - - 4.00 When fully ether sulfate above ingredients were mixed, the mixture was cooled to start 45 ℃. 在另一混合容器内加入下列成分。 Add the following ingredients in a separate mixing vessel.

水 2.00 2.00 2.00 2.00 2.00丁二醇 2.00 2.00 2.00 2.00 2.00Glydant Plus 0.20 0.20 0.20 0.20 2.00当Glydant Plus溶解后,将此混合物加入到第一个混合容器内并冷却至室温。 Water 2.00 2.00 2.00 2.00 2.00 butylene glycol 2.00 2.00 2.00 2.00 2.00Glydant Plus 0.20 0.20 0.20 0.20 2.00 Glydant Plus when dissolved, the mixture was added to the first mixing vessel and cool to room temperature. 冷却后,将1.5g该溶液加到无纺基质上并干燥。 After cooling, the solution was added 1.5g of the nonwoven substrate and dried.

相2:调理乳液在一合适的容器内,在室温条件下混合下列成分,然后在混合状态下加热到70℃。 Phase 2: conditioning emulsion in a suitable container, mix the following ingredients at room temperature, then heated to 70 deg.] C in a mixed state.

SEFA*棉子酸 4.65 4.00 4.65 34.40 4.65SEFA*山萮酸酯 0.35 -- 0.35 2.60 0.35矿脂 -- 1.00 -- -- --脱水山梨醇单油酸酯 -- -- -- 3.00 --聚甘油-4异硬脂酸酯(和)鲸 5.00 5.00 5.00 -- 5.00蜡基二甲基聚硅氧烷(和)月桂酸己酯11从Glodschmidt获得的Abil WE-09*SEFA是脂肪酸蔗糖酯的缩写当混合物达到70℃时,停止加热并在持续搅拌下缓慢地加入下列成分。 SEFA * Cottonseed Acid 4.65 4.00 4.65 34.40 4.65SEFA * behenate 0.35 - 0.35 2.60 0.35 Petrolatum - 1.00 - - - Sorbitan monooleate - - - 3.00 - Poly polyglyceryl-4 isostearate (and) cetyl 5.00 5.00 5.00 - 5.00 wax-based dimethylpolysiloxane (and) hexyl laurate obtained from 11 Glodschmidt Abil WE-09 * SEFA is a sucrose fatty acid ester when the mixture reached Acronym 70 ℃, heating was stopped and stirring was continued under the following ingredients was slowly added.

甘油 90.00 90.00 70.00 60.00 90.00泛酰醇 - - 20.00 - - Glycerin 90.00 90.00 70.00 60.00 90.00 Panthenol - - 20.00 - -

边搅拌边冷却到室温。 It cooled to room temperature with stirring. 将0.17g的该相加到已经含有表面活性剂相的基质上。 0.17g of this phase has been added to the substrate containing the surfactant phase. 通过用水润湿来使用所制得的清洁组合物,该清洁组合物用于清洁皮肤或毛发,并且可将调理乳液沉积到皮肤或毛发上。 Moistened with water by use of the prepared cleaning composition, the cleaning composition for cleaning the skin or hair, and the conditioning emulsion can be deposited onto the skin or hair.

在其它制造方法中,可通过喷涂、移印、喷洒、浸渍或涂层,把起泡型表面活性剂、调理剂和非必需成分分别或同时加到水不溶性基质上或浸渍在其中。 In other manufacturing methods may be applied by spraying, pad printing, spraying, dipping or coating, the lathering surfactants, conditioning agents, and optional ingredients simultaneously or separately added water-insoluble matrix or impregnated therein.

在另一实施方案中,用其它基质如织物基质、水喷交缠基质、天然海绵、合成海绵或高分子网来代替现有基质。 In another embodiment, the textile substrate with other substrates, such as, water jet entangled substrates, natural sponges, synthetic sponges, or to replace the existing polymer network matrix.

Claims (6)

  1. 1.一种可以自由使用的一次性的个人护理清洁和调理产品,该产品含有:(A)水不溶性基质,所述基质选自无纺基质、织物基质、水喷交缠基质、气喷交缠基质、天然海绵、合成海绵、高分子网以及它们的组合,(B)起泡型表面活性剂,所述起泡型表面活性剂为所述水不溶性基质的1%至10%重,并且所述起泡型表面活性剂的HLB值大于10,选自阴离子起泡型表面活性剂、两性起泡型表面活性剂及其混合物,和(C)调理乳液,该乳液为所述水不溶性基质的1%至50%重,并且包含:(i)包含水溶性调理剂的内相,所述水溶性调理剂选自聚丙二醇、聚乙二醇、脲、多元醇、泛酰醇、乙醇酸、乳酸、烟酰胺、吡咯烷酮羧酸钠及其混合物;(ii)包含油溶性调理剂的外相,所述油溶性调理剂选自脂肪酸酯、多元醇多酯、表皮和皮脂烃、羊毛脂、矿物油、聚硅氧烷油、聚硅氧 A free to use disposable personal care cleansing and conditioning product, the product comprising: (A) a water-insoluble matrix, the matrix is ​​selected from non-woven substrates, textile substrates, water jet entangled substrates, air spray deposit wrapped matrix, natural sponge, synthetic sponge, polymer network, and combinations thereof, (B) a lathering surfactant, said surfactant is a lathering said water insoluble substrate from 1% to 10% by weight, and the HLB value lathering surfactant is greater than 10, selected from anionic lathering surfactants, amphoteric lathering surfactants, and mixtures thereof, and (C) conditioning emulsion, the emulsion is of the water-insoluble matrix from 1% to 50% by weight, and comprising: (i) an internal phase comprising water soluble conditioning agent, said water soluble conditioning agent is selected from polyethylene glycol, polyethylene glycol, urea, polyhydric alcohols, panthenol, glycolic acid , lactic acid, niacinamide, sodium pyrrolidone carboxylate and mixtures thereof; external phase (ii) comprises an oil soluble conditioning agent, the oil soluble conditioning agent is selected from fatty acid esters, polyol esters, epidermal and sebaceous hydrocarbons, lanolin, mineral oils, silicone oils, silicone 胶、植物油、植物油加合物、矿脂及其混合物;和(iii)占所述调理乳液0.1%至20%重量的乳化剂,所述乳化剂的HLB值为1-7;其中所述产品含有小于15%重量的水。 Gum, vegetable oil, vegetable oil adduct, petrolatum, and mixtures thereof; and (iii) conditioning emulsion comprises from 0.1 to 20% by weight of an emulsifier, the emulsifier having an HLB value of 1-7; wherein said product containing less than 15% by weight of water.
  2. 2.根据权利要求1的产品,其中所述水溶性调理剂包括一种或多种水溶性调理剂,使得所述的水溶性调理剂的加权算术平均溶解度参数大于10.5;其中所述油溶性调理剂包括一种或多种油溶性调理剂,使得所述的油溶性调理剂的加权算术平均溶解度参数小于或等于10.5。 2. The product according to claim 1, wherein said water soluble conditioning agent comprises one or more water soluble conditioning agents such that the weighted arithmetic mean solubility parameter of said water soluble conditioning agent is greater than 10.5; wherein said oil soluble conditioning comprises one or more oil soluble conditioning agents such that the weighted arithmetic mean solubility parameter of said oil soluble conditioning agent is less than or equal to 10.5.
  3. 3.根据权利要求1的产品,其中所述多元醇多酯包括甘油二酯、甘油三酯,所述多元醇包括甘油、丙二醇、乙基己二醇、己二醇、山梨醇。 3. The product according to claim 1, wherein the polyol esters include diglycerides, triglycerides, the polyhydric alcohols include glycerol, propylene glycol, ethyl hexanediol, hexylene glycol, sorbitol.
  4. 4.制备权利要求1的产品的方法,该方法包含以下步骤:分别或同时将下列物质加入或浸入水不溶性基质中:(a)起泡型表面活性剂,和(b)调理乳液,包含:(i)包含水溶性调理剂的内相,(ii)包含油溶性调理剂的外相,和(iii)乳化剂。 The method for preparing the product as claimed in claim 1, the method comprising the steps of: separately or simultaneously added the following materials or immersing the water-insoluble matrix: (a) a lathering surfactant, and (b) conditioning emulsion, comprising: (i) an internal phase comprising water soluble conditioning agent, (ii) an oil soluble conditioning agent comprising the external phase, and (iii) an emulsifier.
  5. 5.将水溶性调理剂沉积到需要润湿的皮肤或毛发表面的方法,该方法包括如下步骤:(i)使用根据权利要求1的产品以产生泡沫,(ii)将其与皮肤接触,和(iii)用水漂洗。 5. The water soluble conditioning agent is deposited to the surface of the skin or hair of the method will require a wetting, the method comprising the steps of: (i) using the product according to claim 1 to produce a foam, (ii) which is in contact with the skin, and (iii) rinsing with water.
  6. 6.处理需要清洁和调理的皮肤或毛发的方法,该方法包含如下步骤:(i)用水润湿,并使用权利要求1的产品以产生泡沫,(ii)与皮肤接触,和(iii)用水漂洗。 6. The method of processing requires cleansing and conditioning the skin or hair, the method comprising the steps of: (i) wetted with water, and the use of the product according to claim 1 to produce a foam, (ii) in contact with the skin, and (iii) water rinsing.
CN 98806749 1997-05-22 1998-05-20 Cleaning products with improved moisturization CN1191818C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US86174897 true 1997-05-22 1997-05-22
US08980096 US5951991A (en) 1997-05-22 1997-11-26 Cleansing products with improved moisturization

Publications (2)

Publication Number Publication Date
CN1261789A true CN1261789A (en) 2000-08-02
CN1191818C true CN1191818C (en) 2005-03-09

Family

ID=27127643

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 98806749 CN1191818C (en) 1997-05-22 1998-05-20 Cleaning products with improved moisturization

Country Status (5)

Country Link
EP (1) EP1011628A1 (en)
JP (1) JP2001517241A (en)
CN (1) CN1191818C (en)
CA (1) CA2289608C (en)
WO (1) WO1998052538A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6296869B1 (en) 1999-07-30 2001-10-02 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Adhesive cosmetic patch containing alpha or beta hydroxy acids
JP3763567B2 (en) * 2001-01-19 2006-04-05 株式会社資生堂 Cosmetics
US8383851B2 (en) 2010-09-15 2013-02-26 Caravan Ingredients Inc. Lactylate synthesis methods using dilactides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2402730A1 (en) 1973-12-21 1975-07-03 Ciba Geigy Ag Cleaning products for the use in the bathroom or in the shower
GB8809161D0 (en) * 1988-04-19 1988-05-25 Top Line Developments Ltd Cleaning aid
GB9024162D0 (en) * 1990-11-07 1990-12-19 Unilever Plc Detergent composition
ES2135590T3 (en) * 1993-06-18 1999-11-01 Procter & Gamble Personal cleansing system comprising a polymeric diamond mesh sponge and a liquid cleansing agent with humidifier.
WO1995016824A1 (en) * 1993-12-13 1995-06-22 The Procter & Gamble Company Lotion composition for imparting soft, lubricious feel to tissue paper

Also Published As

Publication number Publication date Type
CA2289608A1 (en) 1998-11-26 application
CN1261789A (en) 2000-08-02 application
CA2289608C (en) 2007-04-10 grant
WO1998052538A1 (en) 1998-11-26 application
EP1011628A1 (en) 2000-06-28 application
JP2001517241A (en) 2001-10-02 application

Similar Documents

Publication Publication Date Title
US6524594B1 (en) Foaming oil gel compositions
US6638527B2 (en) Substantially dry cleansing product of improved latherability and wet flexibility
US6358516B1 (en) One-step system for cleansing, conditioning, and treating the skin
US6677294B2 (en) Cleansing compositions
US5989536A (en) Personal cleansing compositions containing alkoxylated ether and cationic ammonium salt for deposition of active agent upon the skin
US4478853A (en) Skin conditioning composition
US20030206940A1 (en) Personal care article with distinct active zone
US20020119174A1 (en) Compositions useful for regulating hair growth containing metal complexes of oxidized carbohydrates
US5948416A (en) Stable topical compositions
US20020035070A1 (en) Method of regulating hair growth using metal complexes of oxidized carbohydrates
US20040242097A1 (en) Cloth-like personal care articles
US7901696B2 (en) Cosmetic device comprising discrete elements
US5607980A (en) Topical compositions having improved skin feel
US6428799B1 (en) Personal care articles
US6391835B1 (en) Alkyl diol impregnate dry cleansing wipe
US5811111A (en) Compositions for topical delivery of active ingredients
US6322801B1 (en) Personal care articles
US20030199404A1 (en) Hotmelt compositions and related articles
US6491928B1 (en) Water-flux limiting cleansing articles
US5824666A (en) Low PH, hydrolytically stable, cosmetic compositions containing acidic actives
US7115551B2 (en) Cleansing articles for skin or hair
US6217889B1 (en) Personal care articles
US20060141014A1 (en) Skin treatment articles and methods
US6267975B1 (en) Personal care articles
US20020071818A1 (en) Skin cleanser containing anti-aging active

Legal Events

Date Code Title Description
C06 Publication
C10 Entry into substantive examination
C14 Grant of patent or utility model
CX01