CN119033901A - Traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome and preparation method thereof Download PDFInfo
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- CN119033901A CN119033901A CN202411206267.6A CN202411206267A CN119033901A CN 119033901 A CN119033901 A CN 119033901A CN 202411206267 A CN202411206267 A CN 202411206267A CN 119033901 A CN119033901 A CN 119033901A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome, which belongs to the field of traditional Chinese medicines and comprises, by weight, 9-20 parts of cassia twig, 9-20 parts of white peony root, 20-40 parts of radix bupleuri, 9-20 parts of radix curcumae, 10-30 parts of angelica sinensis, 10-30 parts of ligusticum wallichii, 30-60 parts of oyster, 9-20 parts of dragon bone, 5-15 parts of radix aconiti lateralis Preparata, 15-30 parts of rhizoma polygonati officinalis, 5-10 parts of folium artemisiae argyi, 5-10 parts of almond, 10-30 parts of peach kernel, 5-15 parts of honey-fried licorice root, 9-20 parts of ginger and 5-15 parts of jujube.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome and a preparation method thereof.
Background
Pelvic floor muscle spasticity syndrome is one of the diagnoses of anorectal diseases in traditional Chinese medicine, and is caused by pelvic floor muscle spasticity, namely abnormal contraction of pelvic floor muscles, and main symptoms comprise difficult defecation, anus pain and the like. In western medicine, this clinical manifestation corresponds to pelvic floor achalasia syndrome and chronic pelvic floor pain syndrome.
According to the theory of traditional Chinese medicine, the anus is located in the pudendum region of the human body, and is also called as the 'soul gate'. The theory of "the body is the five zang organs, the food is not kept for a long time", which means that the normal opening and closing functions of the anus depend on the dispersing and descending of lung qi, the ascending and clearing of spleen, the dredging and releasing of liver qi and the opening of kidney qi. The 'difficult menstruation fourteen difficult' states that 'impaired heart regulates nutrient and defensive qi', which indicates that defensive qi, nutrient and blood are directly related to yin and yang of heart, mental consciousness and thinking activities such as happiness, anger, anxiety, thinking and fear of people are mainly caused by five zang-organs, rely on coordination of yin and yang of five zang-organs, and viscera weakness or qi disorder easily cause 'depression syndrome'. The "Huangdi's internal channel, su Wen, sheng Qi Tong Tian Lun" is written in "yang Qi person, essence being the essence to nourish spirit and flexibility being the tendons to nourish tendons". The term "nourish essence" means that the condition of yang deficiency is manifested as "the condition of weak and urgent limbs, difficult flexing and stretching", and the like, and the condition of weak tendons and vessels.
The etiology and pathogenesis of pelvic floor muscle spasm syndrome involve imbalance between yin and yang and deficiency of qi and blood. Specifically, imbalance of yin and yang of five zang organs, imbalance of heart and kidney, imbalance of water and fire, and possibly symptoms of mental disorder such as insomnia, anxiety and the like, aversion to cold, cold limbs, preference for hot drinks, blockage of channels and collaterals by cold stasis, induced urgent withdrawal of anus and rectum, incapacitation of pain, weakness of lifting and lifting of yang, discomfort of falling and expanding of anus and rectum, one line of bowel movement and more than one day of stool, clear and long urine, frequent nocturia, dry mouth, dry stool, difficult discharge, deficiency of qi and blood, and movement disorder caused by malnutrition of tendons and meat. The treatment is mainly to regulate yin and yang, regulate qi and blood, dispel cold, dispel stasis and calm mind, moisten intestines and relieve constipation.
Currently, the traditional Chinese medicine community considers that the etiology and pathogenesis of pelvic floor muscle spasm syndrome are mainly qi stagnation and blood stasis, damp-heat downward flow and yin deficiency and fire excess. However, this idea ignores the role of emotional factors and lacks the dialectical idea of the "whole concept" of traditional Chinese medicine. Therefore, it is difficult to fundamentally solve the problem by only treating the symptoms, and it is difficult to obtain a satisfactory therapeutic effect.
In western medicine, no clearly effective treatment regimen is currently available. Existing treatments are mainly directed to symptoms including the use of laxatives, anus dilators, muscle relaxants, biofeedback therapies, neuromodulation techniques, etc., which are time consuming and of uncertain efficacy and sometimes exacerbate anxiety and confidence in the patient, and abuse of laxatives can lead to iatrogenic constipation, and improper surgical intervention can exacerbate the condition or cause new complications.
In view of the above, we follow the principle of treating both principal and secondary aspect of disease. By regulating balance of yin and yang, harmonizing qi and blood, dispelling cold stasis, tranquilizing mind, loosening bowel to relieve constipation, improving pelvic floor blood circulation to correct ischemia, nourishing nerve repair injury, relieving muscle spasm, coordinating pelvic floor muscle movement, relieving pain, promoting defecation smoothness, and relieving mental stress. Provides a safe and effective traditional Chinese medicine combination formula with reliable curative effect for clinically treating pelvic floor muscle spasm syndrome.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome and a preparation method thereof, so as to solve the technical problems in the background art.
The traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome comprises, by weight, 9-20 parts of cassia twig, 9-20 parts of white paeony root, 20-40 parts of radix bupleuri, 9-20 parts of radix curcumae, 10-30 parts of Chinese angelica, 10-30 parts of ligusticum wallichii, 30-60 parts of oyster, 9-20 parts of dragon bone, 5-15 parts of prepared aconite root, 15-30 parts of rhizoma polygonati officinalis, 5-10 parts of folium artemisiae argyi, 5-10 parts of almond, 10-30 parts of peach kernel, 5-15 parts of honey-fried licorice root, 9-20 parts of ginger and 5-15 parts of Chinese date.
Further, the traditional Chinese medicine composition comprises, by weight, 15 parts of cassia twig, 15 parts of white peony root, 30 parts of radix bupleuri, 15 parts of radix curcumae, 20 parts of angelica sinensis, 20 parts of ligusticum wallichii, 50 parts of oyster, 15 parts of dragon bone, 15 parts of radix aconiti lateralis preparata, 30 parts of radix polygonati officinalis, 10 parts of folium artemisiae argyi, 10 parts of almond, 20 parts of peach kernel, 10 parts of honey-fried licorice root, 15 parts of ginger and 10 parts of jujube.
The pharmacological actions of the components of each medicinal material are as follows:
Ramulus Cinnamomi is effective in inducing diaphoresis and relieving muscle, warming and activating meridian, supporting yang and activating qi-flowing, and relieving flatulence and lowering qi, and can be used for treating common cold due to wind-cold, cold pain in abdomen, cold and amenorrhea, arthralgia, phlegm retention, edema, palpitation, and running in the body, and contains volatile oil mainly comprising cinnamaldehyde, cinnamic acid, sebum acetate, and phenylpropyl acetate, wherein the main components of the essential oil are cinnamaldehyde, cinnamic acid, sebum acetate, and phenylpropyl acetate, the cassia oil has mild stimulation effect on intestines and stomach to enhance digestion function, and can relieve acute pain of gastrointestinal tract contracture, and the cassia twig decoction has effects of cooling and relieving fever, and the cinnamaldehyde has effects of relieving pain, tranquilizing, and resisting convulsion, and also has effects of relieving cough and promoting urination.
Radix Paeoniae alba is bitter and sour, slightly cold, and has effects of nourishing blood, regulating menstruation, astringing yin, suppressing sweating, softening liver, relieving pain, suppressing liver yang, and can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous sweat, night sweat, hypochondriac pain, abdominal pain, limb contracture pain, headache, giddiness, and contains paeoniflorin, paeonol, tai paeoniflorin, benzoic acid, volatile oil, fatty oil, resin, tannin, sugar, starch, protein, beta-sitosterol, triterpenes, etc., and the paeoniflorin has good spasmolytic effect, and has effects of inhibiting gastric, intestinal, and uterine smooth muscle of rat, and also has effects of relieving pain, tranquilizing, relieving spasm, lowering blood pressure, and dilating blood vessel.
Keel is sweet and astringent in taste, flat, nontoxic, heart-inducing, liver and kidney, large intestine channel relieving and tranquillizing, liver calming and yang suppressing, astringing, main convulsion and epilepsy mania, palpitation, insomnia and amnesia, dizziness, spontaneous perspiration and night sweat, spermatorrhea and enuresis, metrorrhagia and leukorrhagia, chronic diarrhea and dysentery, chronic ulcer and damp sore, and miscellaneous records of 'antiperspirants, reducing stool, drowning blood, nourishing spirit, fixing soul and soul, and calming the five viscera', and the other. "Ben Cao gang mu" in "receive damp, rectocele, promote tissue regeneration and heal wound. "" can astringe the floating healthy qi to strengthen the large intestine and relieve convulsions. The main pulse is also the disease. The product mainly contains calcium carbonate, calcium sulfate, iron, potassium, sodium, chloride, sulfate, etc., and Os Draconis contains calcium salt, and has effects of promoting blood coagulation, reducing permeability of vascular wall, and inhibiting skeletal muscle excitation after absorption.
Oyster has salty and slightly cold properties, returns to liver, gall and kidney channels, relieves the stress of tranquillization, subsiding yang and supplementing yin, and softens and dissipates hard lumps, and is used for treating palpitation, insomnia, dizziness, tinnitus, scrofula, phlegm nodule and mass. The calcined oyster has the functions of astringing, stopping bleeding, relieving pain, treating spontaneous perspiration, night sweat, spermatorrhea, metrorrhagia, gastralgia and acid regurgitation, contains calcium carbonate, calcium phosphate, calcium sulfate, magnesium, aluminum, silicon, ferric oxide, organic matters and the like, and has the functions of acid resistance, mild sedation and anti-inflammation. The calcium carbonate contained in the product has astringent, antacid, and analgesic effects.
Radix bupleuri is pungent and bitter, slightly cold, liver-returning, gall bladder and lung channel, dispersing and antipyretic, soothing liver and relieving depression, lifting yang qi, is used for treating common cold and fever, distending pain in chest and hypochondrium, irregular menstruation, uterine prolapse and rectocele, radix bupleuri contains a-spinasterol, champignon alcohol and saikosaponin, volatile oil and the like, radix bupleuri containing saponin, volatile oil, bupleurum alcohol, champignon alcohol and a-spinasterol, is currently known to be an active ingredient of radix bupleuri, has a plurality of saikosaponin a, b1, b2, c and d, and has the broad central inhibition effects of calming, stabilizing, easing pain, relieving fever, relieving cough and the like.
The curcuma aromatica has the effects of pungent, bitter and cold, returning liver, heart and lung channels, promoting blood circulation to relieve pain, promoting qi circulation to remove depression, clearing away heart-fire and cooling blood, promoting bile flow and relieving jaundice, and is used for treating chest and hypochondrium tingling pain, chest stuffiness and pain, amenorrhea and dysmenorrhea, breast distending pain, fever unconsciousness, epilepsia and mania, hematemesis and epistaxis and jaundice and dark urine.
Rhizoma Ligustici Chuanxiong has effects of warming, invigorating liver, gallbladder, and pericardium channel, promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, relieving pain, treating chest pain, traumatic injury, menoxenia, dysmenorrhea, abdominal mass, headache, rheumatalgia, benCao Chandian, which mainly contains phenolic substances such as alkaloid and ferulic acid, volatile oil lactones, vitamin A, sterol, folic acid, etc., separating effective monomers such as ligustrazine, lollipopine, etc. from alkaloid in recent years, wherein rhizoma Ligustici Chuanxiong alkaloids and phenolic parts thereof have effects of dilating coronary artery, increasing coronary blood flow and myocardial nutrient blood flow, reducing myocardial oxygen consumption, increasing brain and limb blood flow, reducing peripheral vascular resistance, and protecting myocardial ischemia, and preventing experimental thrombosis, sodium ferulate has effects of inhibiting aortic muscle contraction, inhibiting platelet aggregation and anticoagulation, and has effects on central nervous system, and has obvious contraction effect on large-dose contraction of central nervous system, and is stopped for sedation.
Radix Angelicae sinensis is sweet and pungent, and warm; the Chinese angelica root health-care tea has the main components of butylene phthalide, o-carboxybenzene n-pentanone, delta 2-4-dihydro phthalic anhydride and the like, contains a large amount of sucrose, vitamin B12, one-dimensional vitamin A substances and the like, has the effects of inhibiting uterus, reducing uterine rhythmic contraction, uterine muscle relaxant, water or alcohol-soluble non-volatile substances, exciting uterine, reinforcing uterine contraction, and has the effects of treating uterine contraction and also has the effects of treating uterine functional states, the Chinese angelica root has the effects of inhibiting the heart extract, reducing the heart excitability, prolonging the action of the heart, prolonging the action of the coronary artery, preventing coronary artery from being formed, remarkably reducing the blood flow, reducing the blood glucose, reducing the blood fat, reducing the blood glucose, reducing the blood flow, reducing the blood glucose, reducing the blood fat, reducing the blood glucose, and the like.
Semen Persicae is bitter, sweet, flat, and capable of restoring heart, liver and large intestine, promoting blood circulation to remove blood stasis, loosening bowel to relieve constipation, relieving cough and asthma, can be used for treating amenorrhea, dysmenorrhea, mass, pulmonary abscess, appendicitis, traumatic injury, constipation due to dryness of intestine, cough and asthma, contains amygdalin, amygdalase, allantoinase, lactase, vitamin B, volatile oil fatty oil and the like, can increase cerebral blood flow, reduce cerebrovascular resistance, dilate blood vessels of rabbit ears, has a certain anticoagulation effect, contains fatty oil, improves lubricity of intestinal mucosa, is easy to defecation, has the effects of anti-inflammatory, antiallergic, anti-cough and the like, can improve anemia of tumor patients and relieve pain of tumor patients, and is clinically used for treating diseases such as schizophrenia, intestinal obstruction and the like in recent years.
Rhizoma Polygonati Odorati is sweet and slightly cold, has effects of nourishing lung and stomach channel, nourishing yin and moistening dryness, promoting fluid production to quench thirst, and can be used for treating lung and stomach yin injury, dryness-heat cough, dry throat, thirst, internal heat and diabetes, contains Convalvuloside, kavalin, vitamin A, starch and mucin, and has effects of tonifying heart and increasing pressure.
The artemisia leaf is pungent and bitter in taste, warm in nature, low in toxicity, entering liver, spleen and kidney meridians, warming meridians to stop bleeding, dispelling cold to stop pain, external use to dispel dampness and relieve itching, is used for hematemesis, epistaxis, metrorrhagia, miscarriage, lower blood and lower abdomen cold pain, cold menstrual disorder, infertility, external use to skin itch, vinegar Ai Tanwen is used for stopping bleeding due to deficiency-cold, the artemisia leaf decoction contains volatile oil, flavonoid, fat and the like, has the effects of inhibiting plasmin activity, reducing capillary permeability, promoting hemostasis, exciting uterus, inhibiting intestinal canal and relieving fever, has a lasting effect similar to that of isoprenaline, can directly relax smooth muscle of trachea, can obviously inhibit heart contractility, has a certain toxicity in a large dosage, can inhibit heart and cause acute inflammation of stomach and intestine, has obvious central sedation effect and antiallergic effect.
Semen Armeniacae amarum has effects in warming slightly, regulating lung and large intestine, lowering qi, relieving cough and asthma, loosening bowel to relieve constipation, and can be used for treating cough and asthma, chest fullness, excessive phlegm, constipation, amygdalin containing amygdalin, fatty oil, protein and various free amino acids, amygdalin being hydrolyzed to give benzaldehyde and hydrocyanic acid, and amygdalinase and cherry glycosidase. The micro hydrocyanic acid can slightly inhibit cough center to play a role in relieving cough and asthma, the benzaldehyde can inhibit digestion-promoting function of pepsin, and the bitter almond oil has lubricating and relaxing functions.
The ginger is pungent and slightly warm, enters lung, spleen and stomach channels, relieves exterior syndrome and cold, warms middle-energizer and vomit, eliminates phlegm and relieves cough, relieves fish and crab poison, is used for common cold, gastric cold and vomit, cold phlegm and cough, and fish and crab poisoning, contains volatile oil, mainly gingerol, phellandrene, citral, aromatic alcohol, methyl heptenone, nonanal, alpha-borneol and the like, contains pungent components gingerol, can promote secretion of digestive juice, has the effects of improving diet, has the effects of anti-emetic, analgesic, anti-inflammatory and detumescence, can excite vascular exercise center, respiratory center and heart, and can raise blood pressure, and has the effect of sweating.
Fructus Jujubae has effects of warming and sweet, invigorating spleen, stomach, and heart channel, invigorating spleen and replenishing qi, nourishing blood and tranquillizing, relieving drug property, and can be used for treating spleen deficiency anorexia, debilitation loose stool, woman dysphoria, invigorating qi and spleen, and strengthening and protecting healthy qi. "the dosage form of the recipe" refers to "regulating the health and promoting the production of body fluids". The Chinese date decoction is used for filling the stomach of mice for three weeks, and has the effects of increasing weight and enhancing muscle strength and protecting the liver.
Fuzi is pungent, sweet, and toxic due to excessive heat; return to heart, kidney and spleen meridians; the Chinese medicine preparation is used for treating yang deficiency, limb cold pulse, heart yang deficiency, chest stuffiness and heart pain, deficiency cold vomiting and diarrhea, abdominal cold pain, kidney yang deficiency, impotence, cold womb, yin cold edema, yang deficiency exogenous pathogenic factor, cold dampness arthralgia, aconitine, talamine, aconitine Wu Jianjia, aconitine B and other six alkaloids, and has the active components of racemized noraconitine, nordeer-tail grass alkali, chlorinated methyl dopamine and the like, aconite decoction and aconite decoction, has obvious cardiac strengthening effect on isolated hearts (toad, frog and guinea pig), has obvious cardiac strengthening effect after decoction, has analgesic effect on aconitine, has the analgesic effect on aconitine and aconitine, has the effects on the aspects of pain, has the effects on the adrenal gland and the like, has the effects on the aspects of the oral cavity and the adrenal gland, reduces the toxic activity on the peripheral blood, and can obviously reduce the toxicity of the peripheral blood and the peripheral blood of the giant knotweed, and the peripheral blood is obviously reduced by the addition to the aconite.
The honey-fried licorice root is sweet, calm, returns heart, lung, spleen and stomach channels, supplements spleen and stomach, supplements qi and recovers pulse, is used for weakness of spleen and stomach, lassitude, palpitation, pulse generation, middle-jiao and slow-acting, honey-fried, epigastric limb spasm and pain, slow-acting and pain-relieving medicine property, the root and rhizome of the honey-fried licorice root contains glycyrrhizin, which is diglucuronide of glycyrrhetinic acid, which is sweet component of licorice, and contains various flavone components, the hydrolysate of licorice root further separates out the glauberic acid, namely 18-alpha-glycyrrhetinic acid, the honey-fried licorice root has adrenocortical hormone-like effect, the glycyrrhetinic acid has anti-inflammatory and antiallergic effect, glycyrrhizin detoxifies effect, the mechanism of which comprises the combined detoxification effect of glucuronic acid, the absorption effect of glycyrrhizin and adrenocortical hormone-like effect, has obvious inhibition effect on experimental gastric ulcer, the liquorice fluid extract can directly absorb gastric acid, can inhibit basic secretion amount of gastric juice, relieves gastrointestinal tract and has synergistic effect with paeoniflorin, FM100 has synergistic effect on the aspect of 2X 10-4 concentration on release of flavone, and has the effect on the intestinal spasm of the spasms of the cat, and the spasms of the honey-fried licorice root is released from the animal, and the tube has the effect on the intestinal spasm is released from the tissue of the animal, such as 5.
The invention also discloses a preparation method of the traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome, which comprises the following steps:
(1) Weighing the medicinal material components and the weight parts of the traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome, adding water for soaking, and respectively placing the soaked medicinal material components for later use, wherein the water soaked medicinal material components are also placed for later use;
(2) Decocting the medicinal material components soaked in the step (1) twice, and merging the two decoction liquid medicines, standing and layering;
(3) Filtering, recycling, juice taking, bottling and sterilizing the liquid medicine subjected to standing delamination in the step (2) at high temperature to obtain the traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome.
Further, in the step (1), when the medicinal material components are weighed, the radix aconiti carmichaeli preparata, the dragon bone and the oyster in the medicinal material components are weighed and then are packaged singly.
Further, the soaking time of the water adding soaking in the step (1) is 20-40 min.
Further, the weight portion of the water added by the soaking of the water added in the step (1) is 1200.
The method comprises the specific steps of (2) putting the radix aconiti carmichaeli preparata into the water soaked by the medicinal materials in the step (1), decocting for 30min, adding the dragon bone and the oyster, continuously decocting for 30min, adding the rest medicinal materials, continuously decocting for 20-40 min, decocting until the medicinal liquid is 200 parts, filtering to obtain a first decoction, adding 400 parts of water into the filtered medicinal residues, decocting for 20-40 min until the medicinal liquid is 100 parts, filtering to obtain a second decoction, and mixing the first decoction and the second decoction to obtain 300 parts of the traditional Chinese medicine composition.
Further, the high-temperature sterilization temperature in the step (3) is 120-150 ℃.
The invention also discloses a traditional Chinese medicine preparation, which is prepared from the traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome.
Further, the traditional Chinese medicine preparation comprises water decoction, tablet, water honeyed pill, capsule, powder, paste, oral liquid and granule.
By adopting the technical scheme, the invention has the following beneficial effects:
The traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome is safe to take and good in curative effect;
The traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome comprises the following medicinal materials of cassia twig, white paeony root, radix bupleuri, radix curcumae, angelica sinensis, ligusticum wallichii, oyster shell, dragon bone, prepared aconite root, polygonatum odoratum, mugwort leaf, almond, peach kernel, honey-fried licorice root, ginger and Chinese date, wherein the medicinal materials are mutually cooperated to harmonize yin and yang of five organs and regulate qi and blood circulation, so that the pelvic floor blood circulation can be improved, ischemia can be corrected, the damage of nutritive nerve repair can be relieved, muscle spasm can be relieved, movement can be coordinated, pain can be relieved slowly, tension can be eliminated, and the pelvic floor muscle spasm syndrome caused by various clinical causes can be cured rapidly.
Wherein ramulus Cinnamomi and radix Paeoniae are all monarch drugs; ramulus Cinnamomi, pungent and sweet in flavor and warm in temperature are yang-tonifying herbs; the Chinese medicinal composition has the effects of soothing liver, ascending and sinking to reach depression, regulating ying and wei, dredging exterior and interior, dredging meridian, nourishing ying and wei, cooling blood, calming endogenous wind, astringing acid, stopping diarrhea, stopping ying wind, relieving qi, nourishing tendons and vessels, soothing liver, regulating yin and yang, regulating ying and wei, and improving blood microcirculation of the whole body.
Keel, oyster shell, prepared aconite root, radix bupleuri, radix curcumae, angelica sinensis, ligusticum wallichii and peach kernel are all ministerial drugs, the Keel is heavy in taste, enters kidney and liver, assists in heart and kidney accumulation, and is capable of strengthening the vital energy, astringing essence and blood downwards, and has the effect of collecting and taking the spirit and soul, the oyster shell is salty and cold in nature, can reduce cold, can reduce salty people enter kidney, salty people can soften hardness, and simultaneously is white in color and enters lung, can reduce lung qi and generate kidney water, astringe essence and astringe spirit, and achieve the effects of softening hardness and eliminating lump, the Keel and oyster shell are used together, and are used for heavy weight and suppressing yang, transportation of heart yang and kidney water, water fire both help, heart and kidney intersect, the prepared aconite root is capable of tonifying fire and assisting in warming and activating collaterals and dispelling cold, and securing essence, the bupleurum is capable of soothing liver and resolving stagnation, lifting yang qi, and the strip reaches three-focus water channel, the radix curcumae is qi and the qi-invigorating and relieving pain, and the ligusticum is qi in blood. The Chinese angelica root has sweet taste and warm nature, can nourish blood, can also nourish blood, can be used for promoting blood circulation, relieving pain by tonifying qi and blood, can nourish blood without stagnation, can nourish blood without breaking blood, can nourish middle warmer, can nourish blood and regulate blood, can assist white paeony root to nourish blood and benefit yin, can firmly lock the yin blood fed into the body, can nourish liver and kidney to regulate meridians, and can further increase the function of promoting blood circulation and removing obstruction in collaterals by adding peach kernels.
Rhizoma Polygonati Odorati, folium Artemisiae Argyi and semen Armeniacae amarum are used as adjuvant drugs, rhizoma Polygonati Odorati has effects of promoting fluid production, nourishing yin and moistening dryness to prevent yang and body fluid injury, folium Artemisiae Argyi has effects of warming channels and stopping bleeding, dispelling cold and relieving pain, dredging our twelve channels and collaterals, coordinating yin and yang balance in body, semen Armeniacae amarum has effects of dispersing lung qi, loosening bowel to relieve constipation, rhizoma Zingiberis recens has effects of assisting ramulus Cinnamomi with wei yang, and warming middle warmer and stomach.
Fructus Jujubae and radix Glycyrrhizae Preparata can be used as guiding drug, fructus Jujubae can tonify spleen essence to dispel nutrient blood and alleviate drug property, radix Glycyrrhizae Preparata can coordinate the drugs, ramulus Cinnamomi can strengthen yang, and radix Paeoniae can benefit yin.
Drawings
In order that the invention may be more readily understood, a more particular description of the invention will be rendered by reference to specific embodiments thereof which are illustrated in the appended drawings, in which
FIG. 1 is a statistical chart showing the distribution of ages and sexes of 58 clinical patients according to the effect example of the present invention;
FIG. 2 is an age distribution diagram of a male patient according to an embodiment of the present invention;
FIG. 3 is an age distribution of a female patient according to an embodiment of the present invention;
FIG. 4 is a statistical chart of the treatment progress of 58 cases of clinical patients according to the effect example of the present invention;
FIG. 5 is a statistical chart of the treatment effectiveness of 58 clinical patients according to the effect example of the present invention.
Detailed Description
In order to better understand the above technical solutions, the following detailed description will refer to the accompanying drawings and specific embodiments.
The following examples are only for more clearly illustrating the technical aspects of the present invention, and are not intended to limit the scope of the present invention.
Example 1
A preparation method of a traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome, which comprises the following steps:
(1) Weighing 9 parts of cassia twig, 9 parts of white peony root, 20 parts of radix bupleuri, 9 parts of radix curcumae, 10 parts of Chinese angelica, 10 parts of szechuan lovage rhizome, 30 parts of oyster, 9 parts of dragon bone, 5 parts of radix aconiti lateralis preparata, 15 parts of fragrant solomonseal rhizome, 5 parts of mugwort leaf, 5 parts of almond, 10 parts of peach seed, 5 parts of honey-fried licorice root, 9 parts of ginger and 5 parts of Chinese date, wherein the raw materials are weighed and then are respectively packaged singly, and then the weighed medicinal materials are added with 1200 parts by mass of water for 20 minutes, the soaked medicinal materials are respectively placed for standby, and the water after the soaking of the medicinal materials is also placed for standby;
(2) Placing the soaked medicinal material components in the step (1) for standby, firstly placing the radix aconiti carmichaeli preparata into the water soaked in the medicinal material components in the step (1) for decocting for 30min, then adding the dragon bone and the oyster, continuously decocting for 30min, then adding the rest medicinal material components, continuously decocting for 20min, decocting until the medicinal liquid is 200 parts, filtering to obtain a first decoction, adding 400 parts of water into the filtered medicinal residues, decocting for 20min until the medicinal liquid is 100 parts, filtering to obtain a second decoction, mixing the first decoction with the second decoction, standing and layering;
(3) Filtering, recycling, juice taking and bottling the liquid medicine subjected to standing delamination in the step (2), and sterilizing at a high temperature of 120 ℃ to obtain the traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome.
Example 2
A preparation method of a traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome, which comprises the following steps:
(1) Weighing medicinal materials including 15 parts of cassia twig, 15 parts of white peony root, 25 parts of bupleurum, 15 parts of radix curcumae, 20 parts of angelica, 20 parts of ligusticum wallichii, 50 parts of oyster, 12 parts of dragon bone, 10 parts of radix aconiti carmichaeli preparata, 20 parts of polygonatum odoratum, 10 parts of folium artemisiae argyi, 10 parts of almond, 15 parts of peach kernel, 10 parts of honey-fried licorice root, 12 parts of ginger and 10 parts of Chinese date, wherein the raw materials are weighed and then are respectively packaged singly, and then the weighed medicinal materials are soaked in 1200 parts by weight of water for 30min, and the soaked medicinal materials are respectively placed for standby, and the water soaked with the medicinal materials is also placed for standby;
(2) Placing the soaked medicinal material components in the step (1) for standby, firstly placing the radix aconiti carmichaeli preparata into the water soaked in the medicinal material components in the step (1) for decocting for 30min, then adding the dragon bone and the oyster, continuously decocting for 30min, then adding the rest medicinal material components, continuously decocting for 30min, decocting until the medicinal liquid is 200 parts, filtering to obtain a first decoction liquid, adding 400 parts of water into the filtered medicinal residues, decocting for 30min until the medicinal liquid is 100 parts, filtering to obtain a second decoction liquid, mixing the first decoction liquid with the second decoction liquid, standing and layering;
(3) Filtering, recycling, juice taking and bottling the liquid medicine subjected to standing delamination in the step (2), and sterilizing at a high temperature of 135 ℃ to obtain the traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome.
Example 3
A preparation method of a traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome, which comprises the following steps:
(1) Weighing medicinal materials including 20 parts of cassia twig, 20 parts of white peony root, 40 parts of bupleurum, 20 parts of radix curcumae, 30 parts of angelica, 30 parts of ligusticum wallichii, 60 parts of oyster, 20 parts of dragon bone, 15 parts of radix aconiti lateralis preparata, 30 parts of polygonatum, 10 parts of folium artemisiae argyi, 10 parts of almond, 30 parts of peach kernel, 15 parts of honey-fried licorice root, 20 parts of ginger and 15 parts of Chinese date, wherein the raw materials are weighed and then are respectively packaged singly, and then the weighed medicinal materials are soaked in 1200 parts by weight of water for 40min, the soaked medicinal materials are respectively placed for standby, and the water after the soaking of the medicinal materials is also placed for standby;
(2) Placing the soaked medicinal material components in the step (1) for standby, firstly placing the radix aconiti carmichaeli preparata into the water soaked in the medicinal material components in the step (1) for decocting for 30min, then adding the dragon bone and the oyster, continuously decocting for 30min, then adding the rest medicinal material components, continuously decocting for 40min, decocting until the medicinal liquid is 200 parts, filtering to obtain a first decoction, adding 400 parts of water into the filtered medicinal residues, decocting for 40min until the medicinal liquid is 100 parts, filtering to obtain a second decoction, mixing the first decoction with the second decoction, standing and layering;
(3) Filtering, recycling, juice taking and bottling the liquid medicine subjected to standing delamination in the step (2), and sterilizing at a high temperature of 150 ℃ to obtain the traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome.
(Effect verification example)
Based on the diagnosis basis of the traditional Chinese medicine disease diagnosis curative effect standard issued by the national administration, 58 patients conforming to pelvic floor muscle spasm syndrome are selected, and referring to figures 1-3, 20 male patients, 38 female patients, the age range of 35-79 years and the course of disease of more than 1-20 years.
The diagnosis standard in the traditional Chinese medicine disease diagnosis curative effect standard is as follows:
The defecation is difficult, the defecation is performed once in 3-4 days, the quality is multiple, the defecation time is prolonged each time, the anus is painful and the feces is not full, the anus indicates the anal canal to be contracted, and the defecation radiography means that the right angle of the anus is not increased and is more smaller than 90 degrees when the defecation is performed forcefully.
The treatment method comprises weighing the raw materials according to the following prescription, including ramulus Cinnamomi 15g, radix Paeoniae alba 15g, bupleuri radix 30g, radix Curcumae 15g, radix Angelicae sinensis 20g, rhizoma Ligustici Chuanxiong 20g, concha Ostreae 50g, os Draconis 15g, radix Aconiti lateralis Preparata 15g, rhizoma Polygonati Odorati 30g, folium Artemisiae Argyi 10g, semen Armeniacae amarum 10g, semen Persicae 20g, radix Glycyrrhizae Preparata 10g, rhizoma Zingiberis recens 15g, and fructus Jujubae 10g;
the weighed medicinal materials are prepared into decoction for oral administration according to the steps of the preparation method of the traditional Chinese medicine composition for treating pelvic floor muscle spasm syndrome in the embodiment 2, wherein 1 dose of decoction is 300ml per day, 3 times per day, 100ml per time, and 7 days are 1 course of treatment.
Treatment judgment criteria are specified by referring to the traditional Chinese medicine disease diagnosis curative effect criteria:
(1) Cure, the symptom disappears and the defecation radiography is normal;
(2) Improvement of symptoms and defecation radiography;
(3) The symptoms are not healed, and the defecation radiography is not improved.
The treatment effect is as follows:
Referring to figure 5,58 patients, 36 patients are cured, 17 patients are improved, 5 patients are not cured, the total cure rate is 62%, and the total effective rate is 91.3%;
referring to figure 4,58, the number of patients who had been treated with 3 doses was 63.7%, 17 men, 85% in male patients and 52.6% in female patients.
The number of onset of action after 5 doses was taken was 27.5% in 58 patients, 2 men in male patients, 10% in male patients, 14 in female patients, and 36.8% in female patients.
The significant cases were as follows:
Case 1
Some men in the season, 55 years old, and anus distends for more than 10 years.
The symptoms are that the anus is painful and the times of defecation are more. The excrement is dry and hard, the excrement time is about 20-30 minutes each time, the anus is heavy after excrement, the excrement is intentionally not very sensitive, the cold and squatting for a long time are heavy, and the lower left (lower) abdomen is dull.
The special examination comprises the steps of chest and knee position, normal appearance of anus, good function of finger diagnosis, right angle force discharge of anus less than 90 degrees, existence of levator ani trigger pain on the left side of anus, existence of traction pain in a mucosa area beside a left tail bone, no abnormality in microscopic examination.
The patients can get back after taking the medicine for 3 days, the sense of falling is relieved before, the sense of swelling of anus is relieved by 30%, the pain of left lower abdomen is relieved obviously, the times of defecation are normal, and defecation is smooth.
The number of times of stool is normal after the treatment course is repeated. 1-2 times daily, smooth defecation, about 5-7 minutes each time, no discomfort after defecation, and no lower left (lower) abdominal pain.
The special examination of the review comprises the normal appearance of the chest and the knee, the good function of the anus including the finger examination, the disappearance of the trigger pain of levator ani muscle on the left side of the anus, no traction pain in the coccyx and the mucosa area beside the coccyx, and the defecation radiography, wherein the right angle force of the anus is greater than 110 degrees and is normal.
Has been cured, has been visited again after one year, has not recurred, has plagued the patient for more than 10 years, and has very satisfactory treatment result.
Case 2
Some women with focus of the heat, 65 years old, 47 years old of infantile paralysis, scoliosis, left side of the disease, 20 years constipation, intermittent self-use laxative or enema for guiding stool.
The symptoms are that the anus is distended, the defecation is laborious, the defecation time is approximately 1 hour, the defecation is 5-7 days, the defecation is irregular, the stool is dry and hard, the anus has foreign body sensation after the defecation, and the anus has dull pain, dry mouth and cold fear.
The special examination comprises lateral recumbent position, visual appearance of anus, finger examination, weak tension of sphincter in anus, capability of holding levator ani, no extraction of force-discharging action, no sense of distension in traction and compression of tail bone and right mucosa running area, no sense of dryness and hardness in rectum, no obvious abnormality in microscopic examination, and defecation radiography, wherein the right angle force-discharging of anus is less than 90 degrees.
The drug is taken for 3 days and then is used for a return visit, wherein the night time is 2-3 times a day, the defecation is smooth, the foreign body sensation in anus after defecation is reduced by 20-30%, and the pain is hidden in lower abdomen.
The re-diagnosis after one treatment course is that plain anus has no distention and lower abdomen has no pain, and anus and lower abdomen have no pain after defecation.
The special examination comprises lateral recumbent position, visual appearance of anus, about function of finger diagnosis, extraction of force and discharge of anus, coordination of action, slight distension feeling of tail bone and right mucosa running area, light right side, small amount of soft feces touched by rectum, and normal defecation radiography, wherein the right angle force and discharge of anus is more than 110 degrees.
Ordering the breakfast to take the five-cereal porridge to increase dietary fiber, and exercising levator ani every day.
The patient can review the first month and has regular and smooth defecation and no uncomfortable feeling.
The examination of the special department of review includes lateral recumbent position and proper appearance of anus, normal function of finger diagnosis, good and coordinated action and muscle strength of levator ani force discharge, and no abnormality.
Has been healed, and has no recurrence after one year.
Case 3
Plum, 53 years old, 1,3 times of abortion history of 4 pregnant women, 15 the beginning of the year tides, regular menstrual period, pelvic pain before each menstrual period of 40 years old, sexual intercourse pain, and 1 year old.
The symptoms are that the defecation is difficult before 2 years, the defecation is laborious, the defecation is dry and hard, the defecation lasts for more than 10 minutes each time, the defecation is hypodynamia, the anus and rectum are blocked in the near half year, the distention and discomfort are caused, the defecation is endless, the people feel short and lazy to speak, the night sleep is not real, the plain emotion is tense, the people are easy to frighten, and the urine volume is small.
The special examination comprises the steps of chest and knee joint, normal appearance of anus, finger diagnosis, about moderate tension of anus, thick internal sphincter at the rear position, slightly limited movement during force drainage, traction pain in the left mucosa area of coccyx, contact of the tail end of rectum with a small amount of residual hard feces, defecation radiography, and right-angle force drainage of anus of less than 90 degrees.
The medicine is taken for 3 doses and then is used for a return visit, so that complaints are obviously improved, the sense of falling and expanding is only obvious, the symptoms are relieved after the feces are relieved, the feces are soft and form a strip shape, and the sleep is real yesterday.
The repeated diagnosis after the administration of the medicine in one treatment course is that the anus and rectum is sensed to be distended when the patient has obvious stool meaning, the stool sense is strong, the distension disappears after the stool, the defecation process is smooth, the sleep is satisfactory, the emotion is relaxed, and the fear of frightening is avoided.
The special examination comprises the steps of chest and knee joint, normal appearance of anus, finger diagnosis, anus with moderate tension, thick internal sphincter at the rear position, free movement of levator ani force discharge, no traction pain at the left mucosa area of coccyx, and defecation radiography, wherein the right-angle force discharge of anus is more than 110 degrees and is normal.
After one year, the anus symptoms completely disappear, and the defecation is smooth.
Case 4
Some of the plums are female and are 64 years old.
The method comprises the steps of early stage of 20 years, secondary stage of pregnancy and four production, 2 times of abortion, stop menstruation at 48 years, severe climacteric symptoms such as palpitation, dizziness and the like, severe mental depression, strong urine meaning caused by water touch or water sound hearing before 2 years, even urine leakage, anal pain before half a year, diagnosis of gynaecology uterine curettage by endometriosis before 2 months, exacerbation of postoperative anal pain, sudden blood loss before 2 months, and multiple examination is not clearly diagnosed.
The symptoms are that the defecation is difficult, the defecation is laborious for 8 years, the defecation is carried out once for 3 days, the squatting time is long, the anus is painful for half a year, the defecation is aggravated after the defecation, the defecation is not very clear, the mental retardation is poor, the urination frequency is high, and the urination is hard to control.
The chest and knee joint and anus have normal appearance, the internal sphincter is tense and tender, the levator ani amplitude is variable, the traction pain on the two sides is not maintained, the left side is obvious, a large amount of soft feces remain in the rectum, the microscopic examination is not obvious abnormal, and the defecation radiography is that the right angle force of the anus is less than 90 degrees.
The medicine is taken for 3 days for return visit, so that symptoms are not improved.
The patients can get back after taking the medicine for 5 days, the anus is relieved from falling pain, the patients are aggravated after no defecation, and the feeling of defecation is not obvious.
The symptoms of the traditional Chinese medicine are that the patient is conscious every day after one treatment course is finished, the defecation is smooth before, the stool is sticky, the patient has no pain after defecation, the patient can not feel frequent any more, the patient can feel suffocated, the pain on two sides of the lower abdomen is distended, the lumbosacral ache is diffused to the groin, and the stomach is full.
The special examination of the medical treatment for the first time includes the normal function of the internal sphincter, the wide range of levator ani, the maintenance of the coordination of levator ani, the existence of traction pain on the tail bone and the two sides, obvious left side and empty rectum.
And continuing to take 7 doses.
The symptoms of one line of stool every day, smooth defecation, no falling pain after defecation, normal urination, no urine, pain in both sides of lower abdomen, lumbosacral ache, bleeding to groin, gastric fullness and other symptoms disappear, and the mental state is good.
The special examination of the later diagnosis after the second treatment course of medication comprises the steps of finger diagnosis, normal function of the sphincter ani, continuous maintenance of levator ani, forced drainage, no residual stool, abnormal traction and pressure of the coccyx and the left mucosa area, and defecation radiography, wherein the right-angle forced drainage of the anus is more than 110 degrees and normal.
Has been healed, has been visited after one year, has no recurrence, and is quite satisfactory for treatment.
Case 5
Liu somewhere, 55 years old, 16 years old, first birth and second birth, one time of abortion, asexual pain, 54 years old menstruation stopping and obvious climacteric sweating symptoms.
Complaints are that the defecation is difficult and the anus is painful for half a year.
The symptoms are difficult and laborious defecation, long squatting time for 3 days, obvious feeling after defecation, anus falling pain, aggravated falling pain after defecation, thirst, hot drink preference and cold fear.
The special examination comprises the steps of protruding skin and skin at the front anal margin, high tension of the internal sphincter, pain of the internal sphincter during finger insertion, poor stability of levator ani, strong force drainage, a large amount of soft residual excrement of rectum, traction pain of tail bones and mucous membrane areas on two sides, keratinization of the skin part of the anal canal on the right side, constipation and damage and hemorrhage, no abnormality of mucous membrane of the ring Zhou Nazhi, and defecation radiography, wherein the right-angle force drainage of the anus is less than 90 degrees.
The administration is carried out for 5 days, the pain is obviously relieved when people start feeling, and the defecation difficulty is obviously improved.
The symptoms of the treatment are that the defecation is one line a day, the defecation is soft and smooth, the feeling of no exhaustion after the defecation is finished, the anus falling pain is basically disappeared, the aversion to cold is avoided, and the rest is free from abnormality.
The special examination of the treatment course after the end of the medication comprises the steps of finger diagnosis, normal internal sphincter tone, smooth finger feeding, stable levator ani, force drainage, no residual excrement in rectum, disappearance of traction and compression pain in the tail bone and the mucous membrane areas on two sides, and defecation radiography, wherein the right-angle force drainage of the anus is more than 110 degrees and is normal.
Has been healed, and has no recurrence after one year.
Case 6
Zhao is somewhere, man, 54 years old.
Complaints are difficult defecation accompanied by half a year of anus distension.
The symptoms are difficult defecation, laborious defecation, dry and hard stool, anus distension, aggravation after defecation, listlessness, aversion to cold, cold limbs and clear and long urine.
The special examination comprises the steps of chest and knee joint, normal appearance of anus, finger diagnosis, internal sphincter tension, no touch pain, resistance in finger feeding, levering function, no discharge action, obvious acid swelling feeling in traction and compression of the tail bones and mucosa areas on two sides, and defecation radiography, wherein the right-angle force discharge of the anus is less than 90 degrees.
The medicine is taken for 3 days for a return visit, and the anus distension is relieved by 20-30%. Defecation is carried out for two days, and defecation is smooth today.
The symptoms of the treatment are that the feces are soft and shaped and discharged smoothly, anus is left to bulge after the feces are only, the feces can be relieved later, the mental state is good, the limbs are warm, and the feces are small.
The special examination of the treatment after the end of the medication includes finger diagnosis, moderate internal sphincter tension, no tenderness, no resistance in finger feeding, levator ani function, normal guiding force and discharge, self force and discharge of 60%, and no change in acid and swelling feeling of tail bones and mucosa areas on two sides.
And continuing to take 7 doses.
The symptoms of normal defecation, no distention and no abnormality after the second treatment course is finished.
The special examination of the subsequent diagnosis after the second treatment period is finished comprises the steps of finger diagnosis, normal tension of the sphincter ani, good levator ani, good consistency and stability, the existence of coccyx face contact pain, periosteum stimulation, no traction pain in the mucous membrane areas at two sides, and defecation radiography, wherein the right-angle force of the anus is more than 110 degrees, and is normal.
Has been healed, and after one year, the patient returns to visit, and the defecation is normal without anus dropping and swelling.
While the foregoing is directed to embodiments of the present invention, other and further details of the invention may be had by the present invention, it should be understood that the foregoing description is merely illustrative of the present invention and that no limitations are intended to the scope of the invention, except insofar as modifications, equivalents, improvements or modifications are within the spirit and principles of the invention.
Claims (10)
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