CN118974001A - γ-羟基丁酸酯递送化合物以及制备和使用它们的方法 - Google Patents

γ-羟基丁酸酯递送化合物以及制备和使用它们的方法 Download PDF

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CN118974001A
CN118974001A CN202380029978.8A CN202380029978A CN118974001A CN 118974001 A CN118974001 A CN 118974001A CN 202380029978 A CN202380029978 A CN 202380029978A CN 118974001 A CN118974001 A CN 118974001A
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compound
ghb
tablets
mmol
oral
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Chinese (zh)
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S·贝拉
D·达娜
S·冈瑟
A·史密斯
T·米克尔
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Zefra Treatment Co
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Zefra Treatment Co
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119775157A (zh) * 2024-12-11 2025-04-08 西安味品荟食品科技有限公司 一种呈味化合物及其制备方法及应用
CN120699637A (zh) * 2025-06-10 2025-09-26 合肥中聚和成光电材料股份有限公司 液晶取向剂、液晶取向膜及液晶显示元件

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4973304U (https=) 1972-10-12 1974-06-25
DE3909485A1 (de) * 1989-03-22 1990-09-27 Basf Ag Verfahren zur herstellung von butandiol-1,4 und tetrahydrofuran
JP3609457B2 (ja) * 1994-08-25 2005-01-12 三井化学株式会社 サリチル酸誘導体、該誘導体の金属塩および感熱記録材料
GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
JP4576737B2 (ja) 2000-06-09 2010-11-10 Ｊｓｒ株式会社 感放射線性樹脂組成物
JP4838437B2 (ja) * 2000-06-16 2011-12-14 Ｊｓｒ株式会社 感放射線性樹脂組成物
ES2383673T3 (es) * 2000-09-22 2012-06-25 Jpi Commercial, Llc Composiciones de gamma-hidroxibutirato que contienen portadores de hidrato de carbonos
US20040229943A1 (en) * 2003-05-16 2004-11-18 Cephalon Inc Analeptic and drug combinations
JP4973304B2 (ja) * 2007-04-27 2012-07-11 日油株式会社 １，２，３，４−シクロブタンテトラカルボン酸の製造方法
WO2011057199A1 (en) * 2009-11-06 2011-05-12 Adenios, Inc. Compositions for treating cns disorders
JP5531034B2 (ja) * 2012-01-31 2014-06-25 富士フイルム株式会社 感光性樹脂組成物、硬化膜の形成方法、硬化膜、有機ｅｌ表示装置及び液晶表示装置
US8591922B1 (en) * 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
ITMI20132041A1 (it) * 2013-12-06 2015-06-07 Ct Lab Farm Srl Derivati dell'acido gamma-idrossibutirrico, loro preparazione e loro uso medico.
CN113061089A (zh) * 2015-09-23 2021-07-02 凯瑞康宁生物工程（武汉）有限公司 γ-羟基丁酸的前药及其组合物和用途
US20200114015A1 (en) * 2017-04-11 2020-04-16 John K. Thottathil Novel Alpha-Hydroxy Carboxylic Acid And Derivatives And Other GRAS- Based Prodrugs Of Gamma-Hydroxybutyrate (GHB) And Uses Thereof
WO2022214025A1 (zh) * 2021-04-08 2022-10-13 厦门赛诺邦格生物科技股份有限公司 一种聚乙二醇化脂质及其修饰的脂质体、含该脂质体的药物组合物及其制剂和应用

Cited By (2)

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CN119775157A (zh) * 2024-12-11 2025-04-08 西安味品荟食品科技有限公司 一种呈味化合物及其制备方法及应用
CN120699637A (zh) * 2025-06-10 2025-09-26 合肥中聚和成光电材料股份有限公司 液晶取向剂、液晶取向膜及液晶显示元件

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