CN118873620A - A prescription for treating placenta accreta - Google Patents

Abstract

The invention discloses a prescription for treating placenta implantation, which relates to the technical field of traditional Chinese medicines and comprises the following raw materials in parts by weight: 40-50 parts of astragalus membranaceus, 20-25 parts of angelica sinensis, 12-15 parts of ligusticum wallichii, 12-15 parts of peach kernel, 12-15 parts of motherwort herb, 6-9 parts of rhizoma curcumae, 9-12 parts of pollen typhae, 15-18 parts of sargentgloryvine stem, 15-20 parts of lithospermum, 12-15 parts of radix rubiae, 20-30 parts of radix trichosanthis, 12-15 parts of achyranthes bidentata, 12-15 parts of purslane, 12-15 parts of radix sanguisorbae, 12-15 parts of turmeric and 5-10 parts of liquorice. The traditional Chinese medicine prescription provided by the invention has the advantages of quick response, short period, good curative effect, higher cure rate, simple treatment process and relatively low cost.

Description

A prescription for treating placenta accreta

Technical Field

The present invention relates to the technical field of traditional Chinese medicine, and in particular to a prescription for treating placenta accreta.

Background Art

Placenta accreta is one of the common pregnancy complications in obstetrics and gynecology. It refers to the invasion of abnormal placental villi into the uterine myometrium. In clinical practice, it is divided into complete placenta accreta and partial placenta accreta according to the size of the placenta implantation area. According to research and investigation, with the increase in intrauterine operative surgeries in recent years, such as artificial abortion and cesarean section, the incidence of placenta accreta has also continued to increase. The incidence of placenta accreta has increased to 1/533. For placenta accreta with heavy bleeding, severe infection or life-threatening maternal placenta, hysterectomy may be required. However, for parturients with little bleeding, no signs of infection, stable vital signs, small implantation area and the desire to retain the uterus, conservative treatment may be an effective choice. Therefore, the current research and discussion on the issue of placenta accreta has become one of the important research topics in today's medical community.

At present, Western medicine mainly relies on surgery and drug therapy for the treatment of placenta accreta. Although surgery, such as hysterectomy, can quickly stop bleeding and save lives, it has a serious impact on the patient's fertility and does not meet the development needs of today's society. In addition, surgery has high risks and a long recovery time. Drug treatments mainly include mifepristone, rivano, and some chemotherapy drugs (such as methotrexate), which have been recognized for their efficacy in clinical practice. However, these drugs have large side effects and affect breastfeeding. Their clinical safety and patient acceptability still need to be studied. Therefore, finding a safe and effective non-surgical treatment method has become a hot topic in current research.

Traditional Chinese medicine has unique advantages in treating placenta accreta. It aims to achieve the purpose of treatment by using the TCM treatment method of "replenishing qi, removing blood stasis, stopping bleeding, eliminating symptoms and killing embryos", using medicines based on syndrome differentiation, and adding or subtracting medicines according to clinical symptoms, so as to promote the expulsion of placental implant tissue and the repair of the endometrium. However, the efficacy of Chinese medicine prescriptions currently on the market in treating placenta accreta is not ideal, and the course of treatment is long. Based on this, it is very meaningful to develop a Chinese medicine prescription with good efficacy and short course of treatment.

Summary of the invention

In view of the above problems, the present invention provides a prescription for treating placenta accreta, which solves the problems that the efficacy of the Chinese medicinal prescriptions for treating placenta accreta in the prior art is not ideal and the treatment course is long.

In order to achieve the above object, the technical solution adopted by the present invention is as follows:

The invention provides a prescription for treating placenta accreta. The prescription is composed of the following raw materials in parts by weight: 40-50 parts of astragalus, 20-25 parts of angelica, 12-15 parts of chuanxiong, 12-15 parts of peach kernel, 12-15 parts of leonurus, 6-9 parts of curcuma, 9-12 parts of pollen cattail, 15-18 parts of red safflower, 15-20 parts of lithospermum, 12-15 parts of madder, 20-30 parts of trichosanthes, 12-15 parts of achyranthes, 12-15 parts of purslane, 12-15 parts of sanguisorba officinalis, 12-15 parts of turmeric and 5-10 parts of liquorice.

Furthermore, the preparation method of the prescription specifically comprises the following steps:

S1: Take commercially available granules of each raw material according to weight for later use;

S2: Mix the granules of each raw material evenly to obtain a prescription.

Furthermore, the method of using the prescription is: adding hot water to the prescription and brewing it.

Furthermore, the temperature of the hot water is 75°C.

The above drugs, their efficacy and modern pharmacological research are as follows:

Astragalus: Functions and indications: tonifying Qi and strengthening the exterior, promoting diuresis and expelling toxins, discharging pus, and healing sores and promoting tissue regeneration.

Angelica: Functions and indications: nourishing blood, activating blood circulation and replenishing blood, regulating menstruation and relieving pain, moistening the intestines and promoting bowel movements.

Chuanxiong: Functions and indications: promoting blood circulation and qi movement, dispelling wind and relieving pain.

Peach kernel: Functions and indications: breaking up blood and removing blood stasis, moistening the intestines and relieving constipation.

Motherwort: Functions and indications: promoting blood circulation and diuresis, removing blood stasis and promoting new blood circulation.

Curcuma: Functions and indications: promoting qi and removing blood, eliminating symptoms and relieving pain.

Puhuang: Functions and indications: removing blood stasis and relieving pain.

Red twig: Functions and indications: promoting blood circulation, unblocking meridians, dispersing blood stasis and eliminating toxins.

Lithospermum officinale: Functions and indications: removing dead tissue and promoting new growth, cooling blood and stopping bleeding.

Rubia cordifolia: Functions and indications: cooling blood and stopping bleeding, promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain.

Radix Trichosanthis: Functions and indications: clearing away heat, promoting the production of body fluid, reducing swelling and discharging pus.

Achyranthes bidentata: Functions and indications: guiding blood stasis downward, nourishing the liver and kidneys.

Portulaca oleracea: Functions: clearing away heat and detoxifying, cooling blood and stopping bleeding, and stopping dysentery.

Radix Sanguisorbae: Functions and indications: clearing away heat, stopping bleeding, detoxifying and healing sores.

Turmeric: It has the functions of promoting blood circulation, promoting qi circulation, regulating menstruation and relieving pain.

Licorice: Function and indication: harmonizes various medicines.

The combination of the above medicines has the effects of promoting blood circulation and removing blood stasis, replenishing the middle qi, eliminating symptoms and killing the embryo, and is effective in treating placenta implantation.

Compared with the prior art, the present invention has the following beneficial effects:

In the present invention, the combination of various drugs has the effects of promoting blood circulation and removing blood stasis, replenishing the middle qi, eliminating symptoms and killing embryos, can effectively treat placenta implantation, alleviate the pain of patients, retain the reproductive function of women to the greatest extent, and improve clinical efficacy. The Chinese medicine prescription of the present invention has fast effect, short cycle, good efficacy, high cure rate, simple treatment process and relatively low cost.

DETAILED DESCRIPTION

In order to make the purpose and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

The instruments, reagents, materials, etc. involved in the following examples, unless otherwise specified, are all conventional instruments, reagents, materials, etc. in the prior art and can be obtained through regular commercial channels. The experimental methods, detection methods, etc. involved in the following examples, unless otherwise specified, are all conventional experimental methods, detection methods, etc. in the prior art.

In this embodiment, the granules of various raw Chinese medicinal materials were purchased from Jiangyin Tianjiang Pharmaceutical Co., Ltd.

Example 1

This embodiment provides a prescription for treating placenta accreta, which is composed of the following raw materials in parts by weight: 40g of Astragalus, 20g of Angelica, 12g of Ligusticum chuanxiong, 12g of Peach Kernel, 12g of Leonurus japonicus, 6g of Curcuma, 9g of Pollen Typhae, 15g of Red Caulis, 15g of Lithospermum officinale, 12g of Rubia cordifolia, 20g of Radix Trichosanthis, 12g of Achyranthes bidentata, 12g of Portulaca oleracea, 12g of Sanguisorba officinalis, 12g of Curcuma longa, and 5g of Licorice.

The preparation method of the prescription specifically comprises the following steps:

S1: Take commercially available granules of each raw material according to weight for later use;

S2: Mix the granules of each raw material evenly to obtain a prescription.

The method of using this prescription is: divide the medicine in the prescription into two equal parts, add 200mL of 75℃ hot water to each part and brew.

Example 2

This embodiment provides a prescription for treating placenta accreta, which is composed of the following raw materials in parts by weight: 45g of Astragalus, 22g of Angelica, 14g of Chuanxiong, 14g of Peach Kernel, 14g of Leonurus, 8g of Curcuma, 10g of Pollen Typhae, 16g of Red Caulis, 18g of Lithospermum, 14g of Rubia, 25g of Radix Trichosanthis, 14g of Achyranthes, 14g of Portulaca Oleracea, 14g of Sanguisorba Officinalis, 14g of Curcuma, and 8g of Licorice.

The preparation method of the prescription specifically comprises the following steps:

S1: Take commercially available granules of each raw material according to weight for later use;

S2: Mix the granules of each raw material evenly to obtain a prescription.

The method of using this prescription is: divide the medicine in the prescription into two portions equally, add 200mL of 75℃ hot water to each portion and brew.

Example 3

This embodiment provides a prescription for treating placenta accreta, which is composed of the following raw materials in parts by weight: 50g of Astragalus, 25g of Angelica, 15g of Chuanxiong, 15g of Peach Kernel, 15g of Leonurus, 9g of Curcuma, 12g of Pollen Typhae, 18g of Red Caulis, 20g of Lithospermum, 15g of Rubia, 30g of Radix Trichosanthis, 15g of Achyranthes, 15g of Portulaca Oleracea, 15g of Sanguisorba Officinalis, 15g of Curcuma, and 10g of Licorice.

The preparation method of the prescription specifically comprises the following steps:

S1: Take commercially available granules of each raw material according to weight for later use;

S2: Mix the granules of each raw material evenly to obtain a prescription.

The method of using this prescription is: divide the medicine in the prescription into two portions equally, add 200mL of 75℃ hot water to each portion and brew.

Application Example 1

Patient Yuan, female, 27 years old, had difficulty in delivering the placenta during physiological delivery in April 2024. The placenta was removed manually and the uterine cavity felt noticeably rough, accompanied by heavy bleeding. She was diagnosed with placenta accreta and was cured by taking 5 doses of the placenta accreta prescription of Example 1.

Application Example 2

Patient Tian, female, 28 years old, underwent cesarean section in our hospital in May 2024 due to complete placenta previa (multiple hospitalizations for complete placenta previa during pregnancy) and a history of cesarean section. She had heavy bleeding during the operation and obvious placenta implantation was seen. After the operation, the patient was given 5 doses of the placenta implantation prescription of Example 2. In subsequent follow-up, the patient had no vaginal bleeding, and color ultrasound showed no uterine cavity residue.

Application Example 3

Patient Wang, female, 35 years old, had a physiological delivery in our hospital in May 2024. The patient had a history of 3 artificial abortions. The placenta could not be delivered by itself during delivery, so the placenta was removed manually. The uterine cavity was obviously rough and accompanied by heavy bleeding. Uterine balloon compression was then given to stop bleeding. Vaginal bleeding still occurred after the removal 24 hours later. The patient was treated with 7 doses of the placenta implantation prescription of Example 3. In subsequent follow-up, the patient had no vaginal bleeding, and color ultrasound showed no uterine cavity residue.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (4)

1. A prescription for treating placenta implantation, which is characterized in that: the prescription comprises the following raw materials in parts by weight: 40-50 parts of astragalus membranaceus, 20-25 parts of angelica sinensis, 12-15 parts of ligusticum wallichii, 12-15 parts of peach kernel, 12-15 parts of motherwort herb, 6-9 parts of rhizoma curcumae, 9-12 parts of pollen typhae, 15-18 parts of sargentgloryvine stem, 15-20 parts of lithospermum, 12-15 parts of radix rubiae, 20-30 parts of radix trichosanthis, 12-15 parts of achyranthes bidentata, 12-15 parts of purslane, 12-15 parts of radix sanguisorbae, 12-15 parts of turmeric and 5-10 parts of liquorice.

2. The formulation for treating placental implantation according to claim 1, wherein: the preparation method of the prescription specifically comprises the following steps:

s1: taking the commercial granules of the raw materials according to the weight parts for standby;

s2: mixing the granules of the raw materials uniformly to obtain the prescription.

3. The method of claim 1, wherein the method comprises the steps of: the using method of the prescription comprises the following steps: adding hot water into the formulation, and soaking.

4. A method of preparing a formulation for the treatment of placental implantation according to claim 3, wherein: the temperature of the hot water was 75 ℃.