CN118726060B - Atorvastatin statin intermediates feed supplement device is used in dehalogenase production - Google Patents
Atorvastatin statin intermediates feed supplement device is used in dehalogenase production Download PDFInfo
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- CN118726060B CN118726060B CN202411229474.3A CN202411229474A CN118726060B CN 118726060 B CN118726060 B CN 118726060B CN 202411229474 A CN202411229474 A CN 202411229474A CN 118726060 B CN118726060 B CN 118726060B
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- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title claims abstract description 28
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 229960005370 atorvastatin Drugs 0.000 title claims abstract description 28
- 238000004519 manufacturing process Methods 0.000 title abstract description 27
- 239000000543 intermediate Substances 0.000 title description 21
- 239000006052 feed supplement Substances 0.000 title description 7
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title description 2
- 239000000463 material Substances 0.000 claims abstract description 88
- 238000002156 mixing Methods 0.000 claims abstract description 44
- 230000005540 biological transmission Effects 0.000 claims description 26
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 230000001360 synchronised effect Effects 0.000 abstract description 12
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 description 29
- 230000001502 supplementing effect Effects 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 238000010586 diagram Methods 0.000 description 8
- 230000002349 favourable effect Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 238000007599 discharging Methods 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000003139 buffering effect Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000009827 uniform distribution Methods 0.000 description 2
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 description 1
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 102000000853 LDL receptors Human genes 0.000 description 1
- 108010001831 LDL receptors Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M39/00—Means for cleaning the apparatus or avoiding unwanted deposits of microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
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Abstract
本发明涉及混合补料罐领域，尤其涉及一种阿托伐他汀中间体脱卤酶生产用补料装置，包括补料系统，所述补料系统包括机架，所述机架前部下侧安装有固定架，所述固定架固定连接在反应釜外周中部，所述固定架顶端中部外侧固定连接有补料仓，所述补料仓内部顶部后侧贯穿有下料口，所述下料口内中部设置有电磁阀，所述下料口固定连接在混合罐底部，所述混合罐顶部固定连接有双头电机，所述双头电机上部后侧设置有多个进料仓，所述进料仓顶部均固定连接有进料管，本发明能够实现多种物料同步下料，完成多个物料的同步预混，从而能够实现最终的一次性补料工作，有利于减少中间步骤，从而能够有效提升脱卤酶的生产效率。
The present invention relates to the field of mixed feeding tanks, and in particular to a feeding device for producing an atorvastatin intermediate dehalogenase, comprising a feeding system, wherein the feeding system comprises a frame, a fixing frame is installed on the lower side of the front of the frame, the fixing frame is fixedly connected to the middle part of the outer periphery of a reactor, a feeding bin is fixedly connected to the outer side of the middle part of the top of the fixing frame, a feeding port is penetrated through the rear side of the top of the feeding bin, a solenoid valve is arranged in the middle of the feeding port, the feeding port is fixedly connected to the bottom of a mixing tank, a double-headed motor is fixedly connected to the top of the mixing tank, a plurality of feeding bins are arranged on the rear side of the upper part of the double-headed motor, and a feeding pipe is fixedly connected to the top of each feeding bin. The present invention can realize the synchronous feeding of multiple materials and complete the synchronous premixing of multiple materials, thereby realizing the final one-time feeding work, which is beneficial to reducing intermediate steps, thereby effectively improving the production efficiency of dehalogenase.
Description
Technical Field
The invention relates to the field of mixed feed supplementing tanks, in particular to a feed supplementing device for production of atorvastatin intermediate dehalogenase.
Background
Atorvastatin is an enzyme which can inhibit the biosynthesis of HMG-CoA reductase and cholesterol in the liver to reduce the plasma cholesterol and lipoprotein level, and can increase the uptake and catabolism of LDL by increasing the number of low density lipoprotein receptors on the surface of liver, the atorvastatin is generally extracted by an enzyme method, the enzyme method can improve the extraction rate and purity of atorvastatin, the atorvastatin intermediate dehalogenase is an enzyme playing a key role in the atorvastatin synthesis process, the dehalogenase can catalyze related halogenated compounds to carry out dehalogenase, the related intermediates are promoted to be converted in the specific step of atorvastatin synthesis, the method has important significance in the aspects of improving the synthesis efficiency of atorvastatin, controlling the purity and quality of products and the like, in the prior art, materials are generally required to be intermittently added into a tank body for supplementing materials for the purposes of continuous production or material balancing in the production of the dehalogenase, the same auxiliary materials are excessively aggregated at one time, the reaction efficiency is easy to be influenced, the auxiliary materials are possibly added into the tank body for carrying out the supplement, the auxiliary materials are not fully influenced, the quality of the intermediate is not fully influenced, and the situation of the intermediate is not fully solved by the device.
Disclosure of Invention
The invention aims to solve the defects in the background art, and provides a feeding device for the production of an atorvastatin intermediate dehalogenase.
In order to achieve the above purpose, the invention adopts the following technical scheme: the utility model provides an atorvastatin midbody dehalogenase production is with feeding device, includes the feeding system, the feeding system includes the frame, the mount is installed to frame front portion downside, mount fixedly connected with is in reation kettle periphery middle part, mount top middle part outside fixedly connected with feed bin, the inside top rear side of feed bin is run through there is the feed opening, middle part is provided with the solenoid valve in the feed opening, feed opening fixedly connected with is in the blending tank bottom, blending tank top fixedly connected with stud motor, stud motor upper portion rear side is provided with a plurality of feeding storehouse, the equal fixedly connected with inlet pipe in feeding storehouse top, the frame top is all run through to the one end that the feeding storehouse was kept away from to the inlet pipe, the one end fixedly connected with pneumatic conveyer in feeding storehouse is kept away from to the inlet pipe, the equal fixedly connected with feed pipe in feeding storehouse bottom middle part, the one end that the feeding storehouse was kept away from to the feed pipe all runs through stud motor top rear side.
Preferably, the lower part all is through cross rib frame fixedly connected with spliced pole in the feeding storehouse, the spliced pole top all sets up to coniform, the equal fixedly connected with evenly distributed's of spliced pole periphery lower part oblique frame, oblique frame middle part all is provided with the orifice plate, the equal fixedly connected with dead lever second in orifice plate both ends middle part, the dead lever second all rotates with oblique frame to be connected, the dead lever second tip that spliced pole one end was kept away from to the orifice plate all runs through oblique frame and fixedly connected with bevel gear second, bevel gear second all meshing is connected at the awl tooth inslot portion.
Preferably, the double-end motor fixed connection is at the blending tank top, double-end motor lower part drive end fixedly connected with pivot two, pivot periphery upper portion fixedly connected with spacing post, spacing post periphery lower part sliding connection has the vibration dish, the vibration dish bottom outside is provided with evenly distributed's ripples prism, vibration dish bottom is provided with evenly distributed's fixed column, the equal fixed connection of fixed column is on blending tank inside wall body upper portion, fixed column top all with vibration dish bottom sliding connection, the fixed column all sets up between the ripples prism.
Preferably, the middle part of the vibration disc is provided with evenly distributed grid plates, the inner and outer side end parts of the grid plates are all rotationally connected with the vibration disc through a first fixing rod, the outer side of the first fixing rod is fixedly connected with a first bevel gear, the top of the first bevel gear is in meshed connection with a bevel gear ring, the top of the bevel gear ring is in sliding connection with the inner side of the fixing ring, the fixing ring is fixedly connected with the middle upper part of the inner wall body of the mixing tank, the bottom of the fixing ring is fixedly connected with a first magnetic ring with the top of the bevel gear ring, and one surface of the first magnetic ring, which is close to each other, is homopolar.
Preferably, the lower part fixedly connected with mounting bracket in the pivot periphery, the mounting bracket middle part rotates and is connected with the water conservancy diversion auger, evenly distributed's notch has been seted up to the water conservancy diversion auger periphery, the mounting bracket middle part is all run through to the water conservancy diversion auger upper and lower extreme, second drive belt group is installed on water conservancy diversion auger periphery upper portion, second drive belt group installs the upside in the mounting bracket, second drive belt group keeps away from the belt pulley periphery meshing of water conservancy diversion auger one portion and is connected with fixed gear, fixed gear rotates and connects at the fixed axle periphery.
Preferably, the middle part is provided with the revolving rack in the feed bin, the revolving rack periphery runs through feed bin lateral wall body, the revolving rack rotates with feed bin and is connected, revolving rack mid-mounting has evenly distributed's stock guide, the stock guide all sets up to the incline condition, revolving rack periphery fixedly connected with external tooth ring, external tooth ring rear side meshing is connected with drive gear, drive gear fixed connection is in a pivot periphery lower part.
Preferably, the bevel gear grooves are formed in the middle of the inner side of the second magnetic ring, the second magnetic ring is rotationally connected to the middle lower portion in the feeding bin, the third magnetic ring is rotationally connected to the middle lower portion of the outer periphery of the feeding bin, the fluted disc is fixedly connected to the outer periphery of the third magnetic ring, the fluted disc is rotationally connected to the inner side of the fixing plate, and the fixing plate is fixedly connected to the upper portion of the front end of the frame.
Preferably, the rear part of the fluted disc is connected with a connecting gear in a meshed manner, the front part of the fluted disc is fixedly connected with the periphery of the driving end on the upper part of the double-headed motor, the rear part of the fluted disc is fixedly connected with the upper part of the periphery of the rotating shaft I, and the adjacent rotating shafts I are connected through a transmission belt group I.
Preferably, the first rotating shaft is rotationally connected to the rear side of the middle part of the fixing plate, the middle part is longer in length and sleeved with the fixing block at the middle part of the periphery, the first rotating shaft is rotationally connected with the fixing block, and the fixing block is fixedly connected to the middle upper part of the front end of the frame.
Preferably, the fixed axle fixed connection is inboard at the opening, the one end middle part that the pivot two was kept away from on mounting bracket upper portion is seted up to the opening, outer tooth's socket has been seted up at fixed gear periphery middle part, fixed gear passes through outer tooth's socket and is connected with the inboard meshing of fixed ring gear, fixed ring gear fixed connection is at the mixing tank inside wall body middle part, pivot periphery bottom fixedly connected with evenly distributed's guide vane, guide vane all sets up to incline the state.
Compared with the prior art, the invention has the following beneficial effects:
When in actual use, people can utilize the inlet pipe to the inside raw materials that treats of each feeding storehouse, the raw materials can be at first with the spliced pole contact after entering into inside the feeding storehouse, conical through the spliced pole top setting for the raw materials can be broken up by the first time after entering into the feeding storehouse under the effect of impact force, thereby can make the raw materials evenly spread on each inclined frame, can realize evenly leading and unloading to the raw materials through the inclined frame that the slope set up, be favorable to the follow-up transmission work of raw materials.
The double-end motor on the mixing tank can drive the fluted disc to rotate by utilizing the connecting gear, the magnetic ring III on the inner side of the fluted disc can drive the magnetic ring II in the feeding bin to rotate, and when the magnetic ring II rotates, the bevel gear II meshed with the magnetic ring III can be driven by the bevel gear groove II to synchronously rotate, the bevel gear II can drive the pore plate on the inner side of the inclined frame to follow the rotation through the fixing rod II, and the materials passing through the inclined frame can be beaten and scattered through the rotation of the pore plate, so that the materials can be scattered in the feeding bin, the phenomenon that the materials are agglomerated in the transmission process is avoided, the materials can further become more uniform, and the follow-up premixing work is facilitated.
When the fluted disc of feeding storehouse periphery in middle part is driven by the connecting gear in its front portion and rotates, can drive the connecting gear of its rear portion meshing through the fluted disc and rotate in step to can drive pivot one and rotate, the fluted disc of feeding storehouse periphery that set up through the drive belt group that one both sides set up in the pivot one can drive both sides and rotate in step, thereby can realize multiple material synchronous unloading, accomplish the synchronous premix of a plurality of materials, thereby can realize final disposable feed supplement work, be favorable to reducing intermediate step, thereby can effectively promote the production efficiency of dehalogenase.
The raw materials can enter into the blending tank inside through the passage of feeding storehouse bottom, can drive pivot two through the double-end motor and rotate, can contact at first with the vibration dish through entering into the blending tank inside when the material, utilize spacing post to drive the vibration dish and carry out synchronous rotation when pivot two rotate for the fixed column of vibration dish bottom can last with the contact of the ripples prism of vibration dish bottom limit portion, can make the vibration dish continuously vibrate when rotating through fixed column and ripples prism, realize buffering and preliminary mixing to the material, be favorable to in-service use.
When the vibration disk rotates, the bevel gear on the first fixing rod at the end part of the grid plate continuously meshes with the bevel gear ring, so that the first fixing rod and the grid plate can synchronously rotate, further mixing of materials can be realized through the grid plate, uniform scattering of the materials can be completed, the speed of material adding reaction after follow-up feeding can be effectively improved, the production work of dehalogenase is facilitated, the first magnetic ring on the bevel gear ring can be matched with the first magnetic ring at the bottom of the fixing ring, the bevel gear ring is continuously pressed down through repulsive force between the first magnetic rings, and meanwhile, the bevel gear ring can have a certain retraction margin, so that the bevel gear ring can be continuously meshed with the bevel gear during vibration of the vibration disk, the stable work of the grid plate is facilitated, and the practical use is facilitated.
In the work that mixes each supplementary material, pivot two can drive the mounting bracket and rotate in step, can drive fixed gear through the meshing between the external tooth groove on fixed ring gear and the fixed gear when the mounting bracket rotates, can drive one side meshing's drive belt group two and carry out synchronous operation when fixed gear rotates, thereby can drive the water conservancy diversion auger and rotate at a high speed, when the water conservancy diversion auger rotates, limit portion open-ended water conservancy diversion auger can utilize self high-speed rotation to form the whirlwind, thereby can concentrate the material that is broken up by the grid tray and go on the unloading, can further mix the material simultaneously, drive the mounting bracket through pivot two and rotate simultaneously, clear up the inner wall of blending tank through the whirlwind that utilizes the water conservancy diversion auger to form, thereby can concentrate the material clearance that is stained with on the blending tank inner wall down, be favorable to the performance of feed supplement work.
The guide vane at the bottom of the rotating shaft II can form downward airflow by utilizing the inclination angle of the guide vane, so that mixed materials can be discharged into the material supplementing bin through the discharging opening, the guide of the mixed materials can be realized through the guide plate arranged at the inclination of the material supplementing bin, the materials are guided into the reaction kettle to complete the material supplementing operation, meanwhile, the rotating shaft I can utilize the transmission gear and the external gear belt to rotate the rotating frame, and accordingly the materials can uniformly fall onto different guide plates, the materials can be guided by the guide plate to fall onto different positions of the reaction kettle, uniform scattering of the supplementary materials is realized, the quick reaction of the materials after the material supplementing is facilitated, and the production efficiency of dehalogenase can be greatly improved.
Drawings
FIG. 1 is a schematic diagram showing a front perspective structure of a feeding device for the production of atorvastatin intermediate dehalogenase;
FIG. 2 is a schematic diagram showing a rear-view perspective structure of a feeding device for the production of atorvastatin intermediate dehalogenase;
FIG. 3 is a schematic diagram showing a partial structure of a double-headed motor of a feeding device for the production of atorvastatin intermediate dehalogenase;
FIG. 4 is a schematic diagram showing a partial structure in a mixing tank of a feeding device for the production of atorvastatin intermediate dehalogenase;
FIG. 5 is a schematic diagram showing a partial structure in a mounting frame of a feeding device for the production of atorvastatin intermediate dehalogenase;
FIG. 6 is a schematic view showing a partial structure of a vibrating plate of a feeding device for the production of atorvastatin intermediate dehalogenase according to the invention;
FIG. 7 is a schematic view showing the partial structure of the fixing ring and the bevel ring of a feeding device for the production of atorvastatin intermediate dehalogenase;
FIG. 8 is a schematic diagram showing the partial structure of the feeding bin of a feeding device for the production of atorvastatin intermediate dehalogenase;
FIG. 9 is a schematic diagram showing the partial structure of the feeding bin of a feeding device for the production of atorvastatin intermediate dehalogenase;
Fig. 10 is a schematic diagram showing a partial structure of two bevel gears of a feeding device for the production of atorvastatin intermediate dehalogenase.
1. A feeding system; 101. a frame; 102. a reaction kettle; 103. a fixing frame; 104. a mixing tank; 105. conical tooth slot; 106. a double-ended motor; 107. a material guiding pipe; 108. a feeding bin; 109. a feed pipe; 110. a transmission gear; 111. supplementing bin; 112. an outer toothed ring; 113. a fixed block; 114. a first rotating shaft; 115. a first belt conveyor; 116. a fixing plate; 117. a grid plate; 118. fixing the toothed ring; 119. a second rotating shaft; 120. a material guide plate; 121. a rotating frame; 122. a feed opening; 123. a guide vane; 124. a mounting frame; 125. a diversion auger; 126. a second transmission belt group; 127. a fixed gear; 128. an outer spline; 129. a fixed shaft; 130. a vibration plate; 131. a connecting column; 132. a limit column; 133. an opening; 134. a wave prism; 135. fixing the column; 136. a fixing ring; 137. a first magnetic ring; 138. conical toothed ring; 139. bevel gears I; 140. a first fixed rod; 141. a connecting gear; 142. fluted disc; 143. an inclined frame; 144. an orifice plate; 145. a second magnetic ring; 146. a magnetic ring III; 147. bevel gears II; 148. and a second fixing rod.
Detailed Description
The following description is presented to enable one of ordinary skill in the art to make and use the invention. The preferred embodiments in the following description are by way of example only and other obvious variations will occur to those skilled in the art.
1-10, A feeding device for atorvastatin intermediate dehalogenase production, including feeding system 1, feeding system 1 includes frame 101, frame 101 front downside installs mount 103, mount 103 fixedly connected with is in the middle part of the periphery of reation kettle 102, mount 103 top middle part outside fixedly connected with mends feed bin 111, the inside top rear side of mending feed bin 111 runs through has feed opening 122, the middle part is provided with the solenoid valve in feed opening 122, feed opening 122 fixedly connected with is in mixing tank 104 bottom, mixing tank 104 top fixedly connected with stud motor 106, stud motor 106 upper portion rear side is provided with a plurality of feeding storehouse 108, feeding storehouse 108 top all fixedly connected with inlet pipe 109, feeding storehouse 108 one end all runs through frame 101 top, feeding storehouse 108 one end fixedly connected with pneumatic conveyor, feeding storehouse 108 bottom middle part all fixedly connected with feed pipe 107, feeding storehouse 108 one end all runs through stud motor 106 top rear side;
Further, in the concrete implementation, when the fluted disc 142 on the periphery of the feeding bin 108 in the middle is driven to rotate by the connecting gear 141 on the front part of the fluted disc 142, the connecting gear 141 meshed with the fluted disc 142 can be driven to synchronously rotate, so that the first rotating shaft 114 can be driven to rotate, the first transmission belt groups 115 arranged on the two sides of the first rotating shaft 114 can drive the fluted disc 142 on the periphery of the feeding bin 108 arranged on the two sides to synchronously rotate, thereby realizing synchronous discharging of various materials, completing synchronous premixing of the materials, realizing final disposable material supplementing work, being beneficial to reducing intermediate steps, effectively improving the production efficiency of dehalogenase, and then the raw materials can enter the mixing tank 104 through the material guide pipe 107 at the bottom of the feeding bin 108.
Wherein, the middle lower part in the feeding bin 108 is fixedly connected with a connecting column 131 through a cross rib frame, the top of the connecting column 131 is conical, the lower part of the periphery of the connecting column 131 is fixedly connected with an inclined frame 143 which is uniformly distributed, the middle part of the inclined frame 143 is provided with a pore plate 144, the middle parts of the two ends of the pore plate 144 are fixedly connected with a second fixing rod 148, the second fixing rod 148 is rotationally connected with the inclined frame 143, the end part of the second fixing rod 148, which is far away from one end of the connecting column 131, of the pore plate 144 is penetrated through the inclined frame 143 and is fixedly connected with a bevel gear 147, the bevel gear 147 is engaged and connected in a bevel gear groove 105, the bevel gear groove 105 is arranged at the middle part of the inner side of a second magnetic ring 145, the second magnetic ring 145 is rotationally connected at the middle lower part in the feeding bin 108, the lower part of the periphery of the middle part of the feeding bin 108 is rotationally connected with a third magnetic ring 146, the periphery of the magnetic ring III 146 is fixedly connected with a fluted disc 142, the fluted disc 142 is rotationally connected to the inner side of the fixed plate 116, the fixed plate 116 is fixedly connected to the upper part of the front end of the frame 101, the rear part of the fluted disc 142 is fixedly connected with a connecting gear 141, the front part of the middle fluted disc 142 is fixedly connected with the connecting gear 141, the front connecting gear 141 is fixedly connected to the periphery of the upper driving end of the double-headed motor 106, the rear connecting gears 141 are fixedly connected to the upper periphery of the first rotating shaft 114, the adjacent first rotating shafts 114 are connected through a first driving belt group 115, the first rotating shafts 114 are rotationally connected to the rear side of the middle part of the fixed plate 116, the first rotating shaft 114 is longer in length, the middle part of the periphery is sleeved with a fixed block 113, the first rotating shaft 114 is rotationally connected with the fixed block 113, and the fixed block 113 is fixedly connected to the middle upper part of the front end of the frame 101;
Further, in the concrete implementation, when in actual use, people can utilize the inlet pipe 109 to the inside raw materials that treats the supplement of each feeding storehouse 108, the raw materials can at first contact with spliced pole 131 after entering into feeding storehouse 108 inside, conical through the setting of spliced pole 131 top, make the raw materials can be broken up by first time after entering into feeding storehouse 108, thereby can make the raw materials evenly spread on each inclined frame 143, can realize evenly leading and unloading to the raw materials through the inclined frame 143 that the slope set up, be favorable to the follow-up transmission work of raw materials, in this process, can utilize connecting gear 141 to drive fluted disc 142 through the double-end motor 106 on the blending tank 104, can drive the inside magnetic ring two 145 of feeding storehouse 108 through the magnetic ring three 146 of fluted disc 142 and rotate, can drive synchronous rotation through the magnetic ring two 147 of meshing when two 147 rotates, can drive the orifice plate 144 of inclined frame 143 through the dead lever two 147 and follow-up rotation, can be with the material through the inclined frame's of the rotation of orifice plate 144, thereby can make the raw materials that pass through inclined frame to scatter, can further evenly spread in the raw materials, can avoid the follow-up transmission work at the inside raw materials, can further be favorable to the follow-up transmission work, the raw materials, the like, can be more uniform and the quality in the raw materials can be changed in the course.
The double-headed motor 106 is fixedly connected to the top of the mixing tank 104, a second rotating shaft 119 is fixedly connected to the driving end of the lower portion of the double-headed motor 106, a limiting column 132 is fixedly connected to the upper portion of the periphery of the second rotating shaft 119, a vibrating plate 130 is slidably connected to the lower portion of the periphery of the limiting column 132, uniformly distributed waveguide prisms 134 are arranged on the outer side of the bottom of the vibrating plate 130, uniformly distributed fixing columns 135 are arranged on the bottom of the vibrating plate 130, the fixing columns 135 are fixedly connected to the upper portion of the inner side wall of the mixing tank 104, the top of the fixing columns 135 are slidably connected with the bottom of the vibrating plate 130, and the fixing columns 135 are arranged among the waveguide prisms 134;
Further, in the concrete implementation, the second rotating shaft 119 can be driven to rotate through the double-headed motor 106, the second rotating shaft 119 can be driven to synchronously rotate through the limiting columns 132 when materials enter the mixing tank 104 and are in contact with the vibrating plate 130 at first, the fixed columns 135 at the bottom of the vibrating plate 130 can be continuously contacted with the prismatic columns 134 at the bottom end of the vibrating plate 130, the vibrating plate 130 can be continuously vibrated when rotating through the fixed columns 135 and the prismatic columns 134, buffering and primary mixing of the materials are achieved, and practical use is facilitated.
Wherein, the middle part of the vibration plate 130 is provided with evenly distributed grid plates 117, the inner and outer side end parts of the grid plates 117 are rotationally connected with the vibration plate 130 through a first fixed rod 140, the periphery of the first fixed rod 140 at the outer side is fixedly connected with a first bevel gear 139, the top parts of the first bevel gears 139 are respectively connected with a bevel gear ring 138 in a meshed manner, the top parts of the bevel gear rings 138 are respectively connected with the inner side of the fixed rings 136 in a sliding manner, the fixed rings 136 are respectively fixedly connected with the middle upper part of the inner wall body of the mixing tank 104, the inner bottom parts of the fixed rings 136 and the top parts of the bevel gear rings 138 are respectively fixedly connected with a first magnetic ring 137, and one surface of the first magnetic rings 137 close to each other is homopolar;
Further, in the implementation, when the vibration plate 130 rotates, the first bevel gear 139 on the first fixing rod 140 at the end of the grid plate 117 continuously engages with the first bevel gear ring 138, so that the first fixing rod 140 rotates with the grid plate 117 in a same step, further mixing of materials can be achieved through the grid plate 117, uniform distribution of the materials can be achieved, the speed of material adding reaction after subsequent feeding can be effectively improved, production work of dehalogenase is facilitated, the first magnetic ring 137 on the first bevel gear ring 138 can be matched with the first magnetic ring 137 at the inner bottom of the fixing ring 136, the first bevel gear ring 138 is continuously pressed down through repulsive force between the first magnetic rings 137, a certain retraction margin is provided for the first bevel gear ring 138, stable operation of the grid plate 117 is facilitated when the vibration plate 130 vibrates, and practical use is facilitated.
The middle lower part of the periphery of the second rotating shaft 119 is fixedly connected with a mounting frame 124, the middle part of the mounting frame 124 is rotationally connected with a guide auger 125, the upper end and the lower end of the guide auger 125 penetrate through the middle part of the mounting frame 124, the upper part of the periphery of the guide auger 125 is provided with a transmission belt group II 126, the transmission belt group II 126 is arranged on the inner upper side of the mounting frame 124, the periphery of a belt pulley, far away from the first guide auger 125, of the transmission belt group II 126 is in meshed connection with a fixed gear 127, the fixed gear 127 is rotationally connected with the periphery of a fixed shaft 129, the fixed shaft 129 is fixedly connected with the inner side of an opening 133, the opening 133 is formed in the middle part of one end, far away from the second rotating shaft 119, of the upper part of the mounting frame 124, the middle part of the periphery of the fixed gear 127 is provided with an outer tooth slot 128, the fixed gear 127 is in meshed connection with the inner side of a fixed tooth ring 118, the outer periphery of the second rotating shaft 119 is fixedly connected with evenly distributed guide blades 123, and the guide blades 123 are all set to be in an inclined state;
Further, in the concrete implementation, in the work that mixes each supplementary material, pivot two 119 can drive mounting bracket 124 and rotate in step, the meshing between the external tooth groove 128 on through fixed ring gear 118 and fixed gear 127 can drive fixed gear 127 and rotate, can drive the transmission belt group two 126 of one side meshing and carry out synchronous operation when fixed gear 127 rotates, thereby can drive water conservancy diversion auger 125 and rotate at a high speed, when water conservancy diversion auger 125 rotates, limit open-ended water conservancy diversion auger 125 can utilize self high-speed rotation to form the whirlwind, thereby can concentrate the unloading with the material that is broken up by grid plate 117, can further mix the material simultaneously, drive mounting bracket 124 through pivot two 119 and rotate simultaneously, clear up the inner wall of blending tank 104 through the whirlwind that utilizes water conservancy diversion auger 125 to form, thereby can concentrate the material clearance that is stained with on the inner wall of blending tank 104, be favorable to the going on of material supplementing work, simultaneously, can utilize self inclination angle to form the downward air current of orientation through water conservancy diversion blade 123 of pivot two 119 bottom, make the inside 111 of material entering bin 111 can be reached through the material that is followed by the mixture.
The middle part in the supplementing bin 111 is provided with a rotating frame 121, the periphery of the rotating frame 121 penetrates through the outer side wall body of the supplementing bin 111, the rotating frame 121 is rotationally connected with the supplementing bin 111, the middle part of the rotating frame 121 is provided with evenly distributed material guide plates 120, the material guide plates 120 are all arranged in an inclined state, the periphery of the rotating frame 121 is fixedly connected with an outer tooth ring 112, the rear side of the outer tooth ring 112 is in meshed connection with a transmission gear 110, and the transmission gear 110 is fixedly connected to the lower part of the periphery of a first rotating shaft 114;
Further, in the concrete implementation, the guide to the mixed material can be realized through the guide plate 120 of the inside slope setting of feed supplement bin 111, with the material leading-in to the reation kettle 102 inside, accomplish the feed supplement work, simultaneously, can utilize drive gear 110 and outer ring gear 112 to drive revolving rack 121 through pivot one 114 and rotate, thereby can make the material can the equipartition fall to different guide plate 120, make the material can be by the guide plate 120 direction fall to the different positions of reation kettle 102, realize the even scattering to the supplementary material, be favorable to the quick response of material after the feed supplement, can promote the production efficiency of dehalogenase by a wide margin.
Working principle:
in actual use, people can input raw materials to be supplemented into each feeding bin 108 by utilizing the feeding pipes 109, the raw materials firstly contact with the connecting columns 131 after entering the inside of the feeding bins 108, the raw materials can be scattered at the first time under the action of impact force after entering the feeding bins 108 by the conical shape arranged at the tops of the connecting columns 131, so that the raw materials can be uniformly scattered on each inclined frame 143, the raw materials can be uniformly guided and discharged by the inclined frames 143, the follow-up transmission work of the raw materials is facilitated, in the process, the fluted disc 142 can be driven to rotate by utilizing the connecting gears 141 through the double-headed motor 106 on the mixing tank 104, The magnetic ring III 146 on the inner side of the fluted disc 142 can drive the magnetic ring II 145 in the feeding bin 108 to rotate, when the magnetic ring II 145 rotates, the bevel gear II 147 meshed with the magnetic ring III is driven by the bevel gear 105 to synchronously rotate, the orifice plate 144 on the inner side of the inclined frame 143 can be driven by the bevel gear II 147 to rotate along with the fixed rod II 148, and the materials passing through the inclined frame 143 can be scattered through the rotation of the orifice plate 144, so that the raw materials can be scattered in the feeding bin 108, the phenomenon of caking and the like of the raw materials in the transmission process is avoided, the raw materials can be further more uniform, The method is beneficial to the subsequent premixing work, when the fluted disc 142 at the periphery of the feeding bin 108 at the middle part is driven to rotate by the connecting gear 141 at the front part, the fluted disc 142 can drive the connecting gear 141 meshed with the fluted disc to synchronously rotate, so that the first rotating shaft 114 can be driven to rotate, the first transmission belt group 115 arranged on the two sides of the first rotating shaft 114 can drive the fluted disc 142 at the periphery of the feeding bin 108 arranged on the two sides to synchronously rotate, thereby realizing the synchronous discharging of various materials, completing the synchronous premixing of a plurality of materials, realizing the final disposable material supplementing work, being beneficial to reducing the middle steps, so as to effectively improve the production efficiency of dehalogenase, then the raw material can enter the mixing tank 104 through the material guide pipe 107 at the bottom of the feeding bin 108, the double-headed motor 106 can drive the second rotating shaft 119 to rotate, the material can firstly contact with the vibration plate 130 when entering the mixing tank 104, the second rotating shaft 119 can drive the vibration plate 130 to synchronously rotate by utilizing the limit column 132, the fixed column 135 at the bottom of the vibration plate 130 can continuously contact with the prism 134 at the bottom end of the vibration plate 130, the vibration plate 130 can continuously vibrate during rotation through the fixed column 135 and the prism 134, The buffer and preliminary mixing of the materials are realized, the actual use is facilitated, meanwhile, when the vibration plate 130 rotates, the bevel gear I139 on the fixing rod I140 at the end part of the grid plate 117 is continuously meshed with the bevel gear ring 138, so that the fixing rod I140 and the grid plate 117 rotate in the same step, the further mixing of the materials can be realized through the grid plate 117, the uniform scattering of the materials can be completed, the speed of the material adding reaction after the subsequent feeding can be effectively improved, the production work of dehalogenase is facilitated, the magnetic ring I137 on the bevel gear ring 138 can be matched with the magnetic ring I137 at the inner bottom of the fixing ring 136, The conical tooth ring 138 is continuously pressed down through the repulsive force between the magnetic rings one 137, and meanwhile, the conical tooth ring 138 can have a certain retraction margin, so that the conical tooth ring 138 can be continuously meshed with the conical tooth one 139 when the vibration disk 130 vibrates, the stable work of the grid plate 117 is facilitated, the stable work of the grid plate is facilitated, the stable work is facilitated, in the work of mixing various supplementary materials, the second rotating shaft 119 can drive the mounting frame 124 to synchronously rotate, the fixed gear 127 can be driven to rotate through the meshing between the fixed tooth ring 118 and the external tooth groove 128 on the fixed gear 127 when the mounting frame 124 rotates, the second driving belt set 126 meshed on one side can be driven to synchronously operate when the fixed gear 127 rotates, So that the diversion auger 125 can be driven to rotate at a high speed, when the diversion auger 125 rotates, the diversion auger 125 with an opening at the edge can utilize the high-speed rotation to form a rotary cyclone, so that the materials scattered by the grid plate 117 can be concentrated for discharging, the materials can be further mixed, meanwhile, the installation frame 124 is driven to rotate through the second rotating shaft 119, the inner wall of the mixing tank 104 is cleaned by the cyclone formed by the diversion auger 125, so that the materials adhered on the inner wall of the mixing tank 104 can be cleaned and concentrated, the material supplementing work is facilitated, meanwhile, the diversion blades 123 at the bottom of the second rotating shaft 119 can form downward airflow by utilizing the self inclination angle, The mixed materials can be discharged into the material supplementing bin 111 through the discharging opening 122, the guiding of the mixed materials can be realized through the inclined material guiding plate 120 in the material supplementing bin 111, the materials are guided into the reaction kettle 102 to finish the material supplementing work, meanwhile, the rotating shaft I114 can drive the rotating frame 121 to rotate by utilizing the transmission gear 110 and the outer toothed ring 112, so that the materials can uniformly fall onto different material guiding plates 120, the materials can be guided by the material guiding plates 120 to fall onto different positions of the reaction kettle 102, the uniform distribution of the supplementary materials is realized, the rapid reaction of the materials after the material supplementing is facilitated, can greatly improve the production efficiency of dehalogenase.
The foregoing has shown and described the basic principles, principal features and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made therein without departing from the spirit and scope of the invention, which is defined by the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (4)
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| CN207628500U (en) * | 2017-11-30 | 2018-07-20 | 江西抚州新兴化工有限公司 | A kind of water emulsion pesticide continous way feeding device |
| CN109126564A (en) * | 2018-09-29 | 2019-01-04 | 冯志容 | A kind of material stirring equipment with filter effect |
| CN211514176U (en) * | 2018-10-17 | 2020-09-18 | 东莞市佳乐保新材料科技有限公司 | Feeding device with it is multi-functional |
| CN210934675U (en) * | 2019-11-13 | 2020-07-07 | 南通尔康生物有机肥有限公司 | Automatic batching device for producing organic fertilizer |
| CN213913614U (en) * | 2020-11-20 | 2021-08-10 | 黑龙江海之华化工有限公司 | Automobile-used urea production facility with automatic feeding storehouse |
| WO2022041738A1 (en) * | 2021-04-08 | 2022-03-03 | 昆山梓澜电子材料有限公司 | Automatic pulp adding device of coating machine for fluorine release film production |
| CN216935621U (en) * | 2021-12-08 | 2022-07-12 | 海南海韵科技发展有限公司 | High-efficient mixing arrangement is used in processing of pipeline mud jacking material |
| CN217189515U (en) * | 2021-12-22 | 2022-08-16 | 抚州三和医药化工有限公司 | Equipment for preparing fluvastatin intermediate |
| CN116808904A (en) * | 2023-05-06 | 2023-09-29 | 浙江工业大学之江学院 | Lithium battery electrolyte flame retardant mixing device |
| CN117884057A (en) * | 2023-12-18 | 2024-04-16 | 黄冈融锦化工股份有限公司 | Reaction unit is used in production of 2-bromoethyl butyrate |
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