CN118697867A - 稳定的抗osmr抗体制剂 - Google Patents

稳定的抗osmr抗体制剂 Download PDF

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Publication number
CN118697867A
CN118697867A CN202410705360.5A CN202410705360A CN118697867A CN 118697867 A CN118697867 A CN 118697867A CN 202410705360 A CN202410705360 A CN 202410705360A CN 118697867 A CN118697867 A CN 118697867A
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China
Prior art keywords
formulation
concentration
osmr
antibody
arginine
Prior art date
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Pending
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CN202410705360.5A
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English (en)
Chinese (zh)
Inventor
M·C·曼宁
Z·沙鲁克
D·尼科尔斯
P·M·莱维斯奎
R·E·霍尔科姆
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Kiniksa Phamaceuticals Ltd
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Kiniksa Phamaceuticals Ltd
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Application filed by Kiniksa Phamaceuticals Ltd filed Critical Kiniksa Phamaceuticals Ltd
Publication of CN118697867A publication Critical patent/CN118697867A/zh
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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CN202410705360.5A 2017-04-11 2018-04-11 稳定的抗osmr抗体制剂 Pending CN118697867A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762484260P 2017-04-11 2017-04-11
US62/484,260 2017-04-11
US201762524927P 2017-06-26 2017-06-26
US62/524,927 2017-06-26
CN201880024585.7A CN110662761B (zh) 2017-04-11 2018-04-11 稳定的抗osmr抗体制剂
PCT/US2018/027166 WO2018191414A1 (en) 2017-04-11 2018-04-11 Stable anti-osmr antibody formulation

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CN201880024585.7A Division CN110662761B (zh) 2017-04-11 2018-04-11 稳定的抗osmr抗体制剂

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CN118697867A true CN118697867A (zh) 2024-09-27

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CN201880024585.7A Active CN110662761B (zh) 2017-04-11 2018-04-11 稳定的抗osmr抗体制剂

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US (5) US10493149B2 (https=)
EP (1) EP3609916A1 (https=)
JP (3) JP7398958B2 (https=)
KR (2) KR20250091327A (https=)
CN (2) CN118697867A (https=)
AU (2) AU2018251808B2 (https=)
BR (1) BR112019021364A2 (https=)
CA (1) CA3061705A1 (https=)
MA (1) MA53466A (https=)
MX (2) MX2019012255A (https=)
WO (1) WO2018191414A1 (https=)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
SI3456743T1 (sl) 2013-05-30 2022-01-31 Kiniksa Pharmaceuticals, Ltd. Proteini, ki vežejo antigen receptorja onkostatina M
KR20170134748A (ko) 2015-04-14 2017-12-06 추가이 세이야쿠 가부시키가이샤 Il-31 안타고니스트를 유효 성분으로서 함유하는 아토피성 피부염의 예방용 및/또는 치료용 의약 조성물
AU2019388808A1 (en) * 2018-11-29 2021-06-17 Harbour Biomed Therapeutics Limited Anti-PD-L1 antibody preparation
CN114728064B (zh) * 2019-11-20 2025-05-06 中外制药株式会社 含抗体制剂
TWI904261B (zh) 2020-10-19 2025-11-11 美商碩騰服務公司 犬及貓抑瘤素Ｍ受體β之抗體及其用途
CN113274494B (zh) * 2021-06-07 2022-09-20 武汉生物制品研究所有限责任公司 一种抗SARS-CoV-2的重组全人源单克隆抗体的液体制剂

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Publication number Priority date Publication date Assignee Title
ZA912136B (en) * 1990-03-29 1992-11-25 Bristol Myers Squibb Co Anti-oncostatin m monoclonal antibodies
AU2006247039B2 (en) * 2005-05-19 2011-03-03 Amgen Inc. Compositions and methods for increasing the stability of antibodies
MX2008013508A (es) * 2006-04-21 2008-10-31 Novartis Ag Composiciones farmaceuticas de anticuerpos antagonistas anti-cd40.
AR080428A1 (es) 2010-01-20 2012-04-11 Chugai Pharmaceutical Co Ltd Formulaciones liquidas estabilizadas contentivas de anticuerpos
BR112012021576A2 (pt) * 2010-02-26 2016-10-25 Novo Nordisk As composições estáveis contendo anticorpo.
US8883979B2 (en) * 2012-08-31 2014-11-11 Bayer Healthcare Llc Anti-prolactin receptor antibody formulations
SI3456743T1 (sl) * 2013-05-30 2022-01-31 Kiniksa Pharmaceuticals, Ltd. Proteini, ki vežejo antigen receptorja onkostatina M
TWI694836B (zh) * 2014-05-16 2020-06-01 英商葛蘭素史克智慧財產管理有限公司 抗體調配物
BR112019018022A2 (pt) 2017-03-01 2020-06-02 Medimmune Limited Formulações de anticorpos monoclonais

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