CN118688363A - 检测aav的方法 - Google Patents

检测aav的方法 Download PDF

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Publication number
CN118688363A
CN118688363A CN202410630268.7A CN202410630268A CN118688363A CN 118688363 A CN118688363 A CN 118688363A CN 202410630268 A CN202410630268 A CN 202410630268A CN 118688363 A CN118688363 A CN 118688363A
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China
Prior art keywords
aav
capsid
amino acid
particle
raav
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Pending
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CN202410630268.7A
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English (en)
Chinese (zh)
Inventor
X·金
C·R·奥里奥登
L·刘
K·张
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Genzyme Corp
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Genzyme Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59762045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN118688363(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of CN118688363A publication Critical patent/CN118688363A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
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    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C—CHEMISTRY; METALLURGY
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/075—Adenoviridae

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  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202410630268.7A 2016-08-15 2017-08-14 检测aav的方法 Pending CN118688363A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662375314P 2016-08-15 2016-08-15
US62/375,314 2016-08-15
CN201780063531.7A CN110168080B (zh) 2016-08-15 2017-08-14 检测aav的方法
PCT/US2017/046814 WO2018035059A1 (en) 2016-08-15 2017-08-14 Methods for detecting aav

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CN201780063531.7A Division CN110168080B (zh) 2016-08-15 2017-08-14 检测aav的方法

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CN118688363A true CN118688363A (zh) 2024-09-24

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CN201780063531.7A Active CN110168080B (zh) 2016-08-15 2017-08-14 检测aav的方法

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EP (2) EP3851449A1 (https=)
JP (3) JP7021191B2 (https=)
KR (5) KR102538037B1 (https=)
CN (2) CN118688363A (https=)
AU (2) AU2017312951B2 (https=)
CA (1) CA3033856A1 (https=)
CL (2) CL2019000392A1 (https=)
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EP3497207A1 (en) 2019-06-19
IL312792B1 (en) 2025-11-01
JP7021191B2 (ja) 2022-02-16
KR102738219B1 (ko) 2024-12-05
US20210041451A1 (en) 2021-02-11
KR20220107327A (ko) 2022-08-02
IL264819B1 (en) 2024-06-01
JP2024023460A (ja) 2024-02-21
EP3497207B1 (en) 2021-01-06
KR102425289B1 (ko) 2022-07-27
CN110168080B (zh) 2024-05-31
AU2017312951B2 (en) 2024-02-08
JP2019533803A (ja) 2019-11-21
IL312792A (en) 2024-07-01
CL2019002912A1 (es) 2020-03-06
ES2863674T3 (es) 2021-10-11
US20250138024A1 (en) 2025-05-01
AU2017312951A1 (en) 2019-04-04
KR20230078834A (ko) 2023-06-02
SG11201901221YA (en) 2019-03-28
IL312792B2 (en) 2026-03-01
NZ791263A (en) 2025-11-28
NZ751711A (en) 2025-11-28
ZA201900945B (en) 2021-06-30
BR112019002934A2 (pt) 2019-05-14
CN110168080A (zh) 2019-08-23
JP2022064980A (ja) 2022-04-26
MX2019001938A (es) 2019-07-04
RU2019107207A (ru) 2020-09-15
US11698377B2 (en) 2023-07-11
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