CN1186016C - Compound iron-copper intensified nutrient agent - Google Patents

Abstract

The present invention belongs to a compound iron-copper nutrition intensifying agent and a preparation method thereof. The chemical formula of the iron-copper nutrition intensifying agent is CuxFe1-xL2, wherein 0<x<0.3, and L<->=<->OOC-CH2-CH(NH3<+>)-COO<->. The raw materials comprise chemically pure copper carbonate, ferrous carbonate and biochemical reagents of aspartic acid. Right amount of water is added to the copper carbonate, and the copper carbonate and the water are stirred to obtain suspension I. In the same way, water is added to the ferrous carbonate to obtain suspension II. The suspension I and the suspension II are mixed, stirred by electromagnetism and heated to 40 to 50 DEG C., and the weighed aspartic acid is dissolved in the water to prepare aqueous solution of the aspartic acid. Then, the aqueous solution of the aspartic acid is dripped to the mixed suspension of the copper carbonate and the ferrous carbonate. The aspartic acid reacts with the copper carbonate and the ferrous carbonate, and the reaction time is 1.2 to 1.8 hours; after the reaction is completed, the mixed suspension is heated for concentrating, excessive water is evaporated, a target product is prepared by settling, aging, filtering and drying, and the product yield reaches 91.7 to 93.2%.

Description

Composite iron-copper nutrient intensifying agent

Technical Field

The invention belongs to a nutrition enhancer, and particularly relates to a series of composite iron-copper-aspartic acid complex nutrition enhancers.

The invention also relates to a preparation method of the nutrition enhancer.

Background

Iron is a trace element necessary for human body, and the content of iron is the first trace element necessary for human body. Iron is not only necessary for the exchange and transmission of oxygen in the human blood, but also is an indispensable element for some enzymes in the body, such as catalase, peroxidase, phenylalanine hydroxylase, and the like, and many redox systems. It plays an important role in biocatalysis, electron transfer in respiratory chain and other aspects. Copper is a component of many enzymes, catalyzing the progression of many redox reactions. Copper in serum has the effect of detoxifying. Copper also enhances phagocytic capacity of leukocytes. Investigations have shown that iron deficiency is the most common nutrient deficiency. Infants, teenagers and women of childbearing age are high risk groups, and the infant morbidity can reach 75.0-82.5%. The copper intake of infants is often lower than the recommended amount, and other people often have copper deficiency due to some health reasons. Therefore, the development of the high-efficiency compositeiron-copper nutrition enhancer has very important significance for preventing and treating iron and copper deficiency, particularly for promoting the healthy growth of infants, and the high-efficiency composite iron-copper nutrition enhancer is more favorable for the first generation of Chinese nationality than the first generation.

The development of nutrition enhancers has become a patent. However, most of the currently developed trace element nutrition enhancers are single elements, such as calcium-added monosodium glutamate (Chinese patent application No. 96116582), and the composite trace element nutrition enhancers containing a plurality of trace elements are few. Secondly, the trace element nutrition enhancer does not reasonably utilize the synergistic effect of the trace elements, so the nutrition enhancing effect is poor (for example, Chinese patent application No. 95108750). Finally, the trace element carrier of the nutrition enhancer has low efficiency and some side effects. If EDTA is used as carrier (such as Chinese patent application No. 98100374), the metal and EDTA complex has very large stability constant, so it is not favorable to the absorption of trace elements.

Disclosure of Invention

The invention aims to provide a composite iron-copper nutrition enhancer.

Another object of the present invention is to provide a method for preparing the above nutrient supplement.

The series of composite iron-copper nutrition enhancers scientifically utilize the synergistic reaction between iron and copper, and the aspartate which is a nutrient for human bodies is taken as a carrier to prepare the aspartate complex nutrition enhancers of the composite iron and copper. The high-efficiency microelement nutrition enhancer has a series of new characteristics, and further widens the research and application fields of the nutrition enhancer, and makes a contribution to the health promotion of people.

The high-efficiency series composite iron-copper nutrition enhancer of the invention is based on the following main scientific principles: 1) balanced intake of nutrients. The human body needs a plurality of nutrient substances, and the nutrient substances are reasonably matched according to the needs of the human body. Therefore, the effect of singly supplementing one essential trace element is good, and the collocation of a plurality of essential trace elements is more reasonable. 2) Scientifically utilizes the synergistic effect between iron and copper. Besides many other important biological functions, copper is also an important component of ceruloplasmin (iron oxidase) and is directly involved in the redox process of iron, thereby affecting the absorption, transportation and utilization of iron, and thus the deficiency of copper can also lead to iron deficiency. In this case, the simple iron supplement does not work, and copper must be supplemented at the same time. On the contrary, the existence of a proper amount of copper not only ensures the requirement of the human body on the copper, but also ensures the reasonable and scientific absorption, transportation and utilization of the iron through the synergistic effect on the iron. For the infant and other people who are susceptible to iron and copper deficiency, the composite iron-copper nutrition enhancer developed according to the principle of synergistic action between iron and copper can certainly achieve the peculiar effect of getting twice the result with half the effort.

The chemical formula of the high-efficiency series composite iron-copper nutrition enhancer provided by the invention is as follows:

Cu_xFe_1-xL₂

wherein x is more than 0 and less than 0.3; l is^-＝^-OOC-CH₂-CH(NH₃ ⁺)-COO^-

The used raw materials are as follows: chemically pure copper carbonate, ferrous carbonate and aspartic acid (HL, biochemical reagent).

The preparation method of the high-efficiency series composite iron-copper nutrition enhancer is simple and easy to implement. The present invention relates to a series of composite iron-copper nutrient intensifying agent (Cu)_xFe_(1-x)L₂) Weighing corresponding reactants of copper carbonate, ferrous carbonate and a biochemical reagent of aspartic acid according to the stoichiometric ratio. Adding proper amount of water into copper carbonate, and stirring to obtain suspension. Water is also added to make the ferrous carbonate into a suspension. Mixing the two, placing the mixture on an electromagnetic stirring heater, heating the mixture to 40-50 ℃, and simultaneously rapidly stirring the suspension. Dissolving the weighed aspartic acid in water to prepare an aqueous solution. Then, an aqueous solution of aspartic acid was added dropwise to the mixed suspension of copper carbonate and ferrous carbonate. Aspartic acid reacts with copper carbonate and ferrous carbonate. The reaction proceeds as follows:

carbon dioxide bubbles continuously escape in the reaction process, and copper carbonate and ferrous carbonate are continuously converted into a complex with aspartic acid. When the carbon dioxide bubbles stop escaping, the reaction is basically completed, and at the moment, the heating is still continued and the stirring is carried out for a certain time, so that the reaction is completely carried out. The reaction temperature is controlled to be 40-50 ℃, and the reaction time is kept to be 1.2-1.8 h. After the reaction is finished,heating, concentrating and evaporating excessive water, and standing for aging to separate out the product as much as possible. Filtering and drying to obtain the prepared target product, wherein the drying mode can adopt room temperature natural drying or infrared lamp baking. The chemical formula of the series of composite iron-copper nutrition enhancers is as follows: cu_xFe_(1-x)L₂Wherein L is aspartate. The product yield is up to 91.7-93.2%.

The preparation method of the nutrition enhancer has the following remarkable characteristics: the nutrition enhancer can be directly prepared by selecting appropriate raw materials and carrying out one-step inorganic chemical reaction. The preparation process of the nutrition enhancer is very simple, easy to master and easy to industrialize; the preparation process does not need complex and precise instruments and equipment, and only needs the simplest and common equipment in the chemical production and common chemical production units. Obviously, the method is easy to popularize and apply; the preparation reaction is single, and no side reaction and any other products need to be separated. Meanwhile, the preparation reaction does not have any reverse reaction because of gas emission, so that the preparation reaction can be completely and thoroughly carried out. The two points ensure that the target product with high purity and high yield can be directly obtained without adding any separation process.

The high-efficiency series composite iron-copper nutrition enhancer provided by the invention has a plurality of outstanding advantages. The nutrition enhancer can simultaneously supplement trace elements of iron and copper which are necessary for human bodies, and has special significance for high-risk infants and other crowds with iron deficiency and copper deficiency complications; the series of composite iron-copper nutrition enhancers provided by the invention scientifically utilize the synergistic effect between iron and copper, and can obviously improve the supplement effect of trace elements; the series of composite iron-copper nutrition intensifying agents provided by the invention use the nutrient substance aspartic acid of human body as a carrier, and generate a complex with necessary trace elements of iron and copper. Therefore, the nutrition enhancer also has the outstanding characteristics of good stability, easy storage and transportation, no toxic or side effect and the like.

Detailed Description

The invention is further illustrated by the following specific examples.

Example 1

Exactly 1.00 mole of aspartic acid, 0.10 mole of copper carbonate and 0.40 mole of ferrous carbonate were weighed out separately. Adding water and stirring to make copper carbonate and ferrous carbonate into suspension, mixing them and placing them on an electromagnetic stirrer to heat them, at the same time stirring, controlling reaction temp. at 45 deg.C. Aspartic acid was dissolved in water to prepare an aqueous solution of aspartic acid, which was then added dropwise to the above suspension of copper carbonate and ferrous carbonate. The copper carbonate and the ferrous carbonate are continuously dissolved in the reaction process, and carbon dioxide bubbles escape at the same time. When the evolution of carbon dioxide bubbles ceases, the preparation reaction is substantially complete. The reaction was then continued with stirring to ensure quantitative progress.The reaction time was kept at 1.5 h. And slowly evaporating to remove excessive water so as to ensure that the synthesized target product is completely separated out. Standing for aging, and filteringThe synthesized product is naturally dried at room temperature to obtain the compositeiron-copper nutrition enhancer of the invention, and the chemical formula is as follows: cu_0.2Fe_0.8L₂(L ═ aspartate), yield was 92.1%.

Example 2

The reaction temperature was maintained at 40 ℃ and the rest of the procedure was as in example 1. The chemical formula of the synthesized target product is as follows: cu_0.2Fe_0.8L₂The yield thereof was found to be 91.9%.

Example 3

The reaction temperature was maintained at 50 ℃ and the rest of the procedure was as in example 1. The chemical formula of the synthesized target product is as follows: cu_0.2Fe_0.8L₂The yield thereof was found to be 92.5%.

Example 4

Exactly 0.40 mol of aspartic acid, 0.04 mol of copper carbonate and 0.16 mol of ferrous carbonate were weighed out separately. The reaction time was controlled to 1.2 h. The rest of the procedure was the same as in example 1. The chemical formula of the synthesized target product is as follows: cu_0.2Fe_0.8L₂The yield thereof was found to be 917%.

Example 5

Exactly 2.00 moles of aspartic acid, 0.20 moles of copper carbonate and 0,80 moles of ferrous carbonate were weighed out separately. The reaction time was controlled to 1.8 h. The rest of the procedure was the same as in example 1. The chemical formula of the synthesized target product is as follows: cu_0.2Fe_0.8L₂The yield thereof was found to be 93.0%.

Example 6

Exactly 1.00 mole of aspartic acid, 0.05 mole of copper carbonate and 0.45 mole of ferrous carbonate were weighed out separately. The rest of the procedure was the same as in example 1. The chemical formula of the synthesized target product is as follows: cu_0.1Fe_0.9L₂The yield thereof was found to be 93.2%.

Example 7

Exactly 1.00 mole of aspartic acid, 0.15 mole of copper carbonate and 0.35 mole of ferrous carbonate were weighed out separately. The rest of the procedure was the same as in example 1. The chemical formula of the synthesized target product is as follows: cu_0.3Fe_0.7L₂The yield thereof was found to be 92.7%.

Example 8

The product obtained by filtration was dried under an infrared lamp. The rest of the procedure was the same as in example 1. The chemical formula of the synthesized target product is as follows: cu_0.2Fe_0.8L₂The yield thereof was found to be 92.4%.

Claims (2)

1. A composite iron-copper nutrition enhancer has a chemical formula as follows:

Cu_xFe_1-xL₂

wherein x is more than 0 and less than 0.3; l is^-＝^-OOC-CH₂-CH(NH₃ ⁺)-COO^-

The used raw materials are as follows: chemically pure copper carbonate, ferrous carbonate and biochemical reagent aspartic acid.

2. The method for preparing the composite iron-copper nutrition enhancer of claim 1, weighing the corresponding reactants of copper carbonate, ferrous carbonate and aspartic acid according to the stoichiometric ratio, adding water into the copper carbonate, and stirring to form a suspension; adding water to make ferrous carbonate into suspension; mixing the two, placing the mixture on an electromagnetic stirring heater, heating the mixture to 40-50 ℃, quickly stirring the mixture, dissolving the weighed aspartic acid in water to prepare an aqueous solution of the aspartic acid, and then dropwise adding the aqueous solution of the aspartic acid into a mixed suspension of copper carbonate and ferrous carbonate; and continuously escaping carbon dioxide bubbles in the reaction process, continuously heating and stirring when the carbon dioxide bubbles stop escaping, keeping the reaction time at 1.2-1.8h, heating and concentrating to evaporate excessive water after the reaction is finished, standing for aging, separating out a product, filtering and drying to obtain the target product.