CN118488959A - 低聚核酸化合物的制造方法 - Google Patents
低聚核酸化合物的制造方法 Download PDFInfo
- Publication number
- CN118488959A CN118488959A CN202280086091.8A CN202280086091A CN118488959A CN 118488959 A CN118488959 A CN 118488959A CN 202280086091 A CN202280086091 A CN 202280086091A CN 118488959 A CN118488959 A CN 118488959A
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- nucleic acid
- iii
- solution containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021212132 | 2021-12-27 | ||
| JP2021-212132 | 2021-12-27 | ||
| PCT/JP2022/048385 WO2023127918A1 (ja) | 2021-12-27 | 2022-12-27 | オリゴ核酸化合物の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118488959A true CN118488959A (zh) | 2024-08-13 |
Family
ID=86999200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280086091.8A Pending CN118488959A (zh) | 2021-12-27 | 2022-12-27 | 低聚核酸化合物的制造方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250066396A1 (https=) |
| EP (1) | EP4458833A4 (https=) |
| JP (1) | JPWO2023127918A1 (https=) |
| KR (1) | KR20240129006A (https=) |
| CN (1) | CN118488959A (https=) |
| AU (1) | AU2022424485A1 (https=) |
| CA (1) | CA3244382A1 (https=) |
| WO (1) | WO2023127918A1 (https=) |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3398378B2 (ja) | 1989-12-20 | 2003-04-21 | アンチビラルス・インコーポレイテツド | リン含有キラルインターサブユニットリンケージを有する非電荷モルホリノ―基体ポリマー |
| US6784291B2 (en) | 2000-05-04 | 2004-08-31 | Avi Biopharma, Inc. | Splice-region antisense composition and method |
| ATE498685T1 (de) | 2004-06-28 | 2011-03-15 | Univ Western Australia | Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon |
| US7790694B2 (en) | 2005-07-13 | 2010-09-07 | Avi Biopharma Inc. | Antisense antibacterial method and compound |
| MX2010004955A (es) | 2007-11-15 | 2010-06-30 | Avi Biopharma Inc | Metodo de sintesis de oligomeros de morfolina. |
| CN112574988A (zh) | 2008-10-24 | 2021-03-30 | 萨雷普塔治疗公司 | 用于dmd的多外显子跳跃组合物 |
| JP5786109B2 (ja) | 2008-10-27 | 2015-09-30 | プロセンサ テクノロジーズ ベー．フェー． | Ｄｕｃｈｅｎｎｅ型筋ジストロフィーｍＲＮＡ前駆体のエクソン４５の効率的なスキッピングのための方法及び手段 |
| LT2499249T (lt) | 2009-11-12 | 2018-12-27 | The University Of Western Australia | Priešprasmės molekulės ir patologijų gydymo būdai |
| TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| RS55610B1 (sr) | 2010-09-30 | 2017-06-30 | Nippon Shinyaku Co Ltd | Derivat morfolino nukleinske kiseline |
| CN117721110A (zh) | 2011-12-28 | 2024-03-19 | 日本新药株式会社 | 反义核酸 |
| EP2816053B1 (en) | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Base-protected oligonucleotide |
| EP2921499B1 (en) | 2012-11-14 | 2020-01-22 | Takeda Pharmaceutical Company Limited | Method for liquid-phase synthesis of nucleic acids |
| RS58529B1 (sr) | 2013-03-14 | 2019-04-30 | Sarepta Therapeutics Inc | Sastavi koji preskaču egzon za tretiranje mišićne distrofije |
| CA2906812A1 (en) | 2013-03-15 | 2014-09-18 | Sarepta Therapeutics, Inc. | Improved compositions for treating muscular dystrophy |
| WO2014189142A1 (ja) * | 2013-05-24 | 2014-11-27 | 味の素株式会社 | モルフォリノオリゴヌクレオチドの製造方法 |
| SMT201900169T1 (it) | 2014-03-12 | 2019-05-10 | Nippon Shinyaku Co Ltd | Acido nucleico antisenso |
| RU2695430C2 (ru) | 2014-06-17 | 2019-07-23 | Ниппон Синяку Ко., Лтд. | Антисмысловые нуклеиновые кислоты |
| SI3351633T1 (sl) | 2015-09-15 | 2020-09-30 | Nippon Shinyaku Co., Ltd. | Protismiselna nukleinska kislina |
| CN112384520B (zh) * | 2018-05-10 | 2024-06-11 | 日本新药株式会社 | 寡核苷酸化合物的制造方法 |
| JP6770553B2 (ja) * | 2018-07-20 | 2020-10-14 | 藤本化学製品株式会社 | アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法 |
| CA3161586A1 (en) * | 2019-11-13 | 2021-05-20 | Nippon Shinyaku Co., Ltd. | Method for producing oligonucleic acid compound |
| EP4059943A4 (en) * | 2019-11-13 | 2024-01-31 | Nippon Shinyaku Co., Ltd. | METHOD FOR PRODUCING OLIGONUCLEIC ACID COMPOUND |
| CN118109468A (zh) | 2019-12-26 | 2024-05-31 | 日本新药株式会社 | 诱导外显子50的跳读的反义核酸 |
| US20230140736A1 (en) | 2020-02-28 | 2023-05-04 | Nippon Shinyaku Co., Ltd. | Antisense nucleic acid inducing skipping of exon 51 |
| US20240254158A1 (en) * | 2021-04-28 | 2024-08-01 | Nippon Shinyaku Co., Ltd. | Method for producing oligonucleic acid compound |
-
2022
- 2022-12-27 CA CA3244382A patent/CA3244382A1/en active Pending
- 2022-12-27 CN CN202280086091.8A patent/CN118488959A/zh active Pending
- 2022-12-27 US US18/723,577 patent/US20250066396A1/en active Pending
- 2022-12-27 WO PCT/JP2022/048385 patent/WO2023127918A1/ja not_active Ceased
- 2022-12-27 JP JP2023571077A patent/JPWO2023127918A1/ja active Pending
- 2022-12-27 EP EP22916140.1A patent/EP4458833A4/en active Pending
- 2022-12-27 AU AU2022424485A patent/AU2022424485A1/en active Pending
- 2022-12-27 KR KR1020247025422A patent/KR20240129006A/ko active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023127918A1 (ja) | 2023-07-06 |
| EP4458833A1 (en) | 2024-11-06 |
| CA3244382A1 (en) | 2025-02-26 |
| JPWO2023127918A1 (https=) | 2023-07-06 |
| EP4458833A4 (en) | 2025-12-31 |
| US20250066396A1 (en) | 2025-02-27 |
| AU2022424485A1 (en) | 2024-07-11 |
| KR20240129006A (ko) | 2024-08-27 |
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| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
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