CN118384239A - A composition for strengthening the body and preventing and treating COVID-19 and a preparation method thereof - Google Patents

A composition for strengthening the body and preventing and treating COVID-19 and a preparation method thereof Download PDF

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CN118384239A
CN118384239A CN202211592842.1A CN202211592842A CN118384239A CN 118384239 A CN118384239 A CN 118384239A CN 202211592842 A CN202211592842 A CN 202211592842A CN 118384239 A CN118384239 A CN 118384239A
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parts
decoction
composition
radix
root
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刘铜华
吴丽丽
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Beijing Kuizheng Traditional Chinese Medicine Technology Co ltd
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Beijing Kuizheng Traditional Chinese Medicine Technology Co ltd
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Priority to CN202211592842.1A priority Critical patent/CN118384239A/en
Priority to PCT/CN2023/137644 priority patent/WO2024125422A1/en
Priority to KR1020257023192A priority patent/KR20250117445A/en
Priority to CN202380085042.7A priority patent/CN120417920A/en
Priority to JP2025534727A priority patent/JP2025541326A/en
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Abstract

The invention relates to a composition for strengthening body resistance and preventing and curing new crowns and a preparation method thereof. It is prepared from astragalus root, white atractylodes rhizome, schisandra fruit, ledebouriella root, honeysuckle flower, capsule, isatis root, cordate houttuynia, reed rhizome, root of Chinese trichosanthes, root of ballon flower and licorice root, and is prepared into any dosage form, such as formulated granules, decoction, tablets, capsules, soft capsules, drop pills or pills, by adopting pharmaceutically acceptable carriers or excipients. Has effects of invigorating qi, consolidating superficial resistance, clearing away heat and toxic materials, clearing lung-heat, and relieving sore throat. Is suitable for people with low immunity, old and weak people or people with body resistance reduced accompanied with other diseases to prevent exogenous diseases and or infectious diseases, and people infected by novel coronavirus. Clinical researches show that the symptoms of patients suffering from novel coronavirus infection treated by the invention can be basically disappeared in 20 hours when the patients suffering from the novel coronavirus infection are mostly improved in 6-8 hours due to body temperature, pharyngalgia, general soreness and sleeping difficulties, and the curative effect of the invention on patients suffering from novel coronavirus infection is definite.

Description

一种扶正固本防治新冠的组合物及其制备方法A composition for strengthening the body and preventing and treating COVID-19 and a preparation method thereof

一、技术领域1. Technical Field

本发明属于医药技术领域，具体涉及一种扶正固本防治新冠的组合物及其制备方法。The present invention belongs to the field of medical technology, and specifically relates to a composition for strengthening the body and preventing and treating COVID-19 and a preparation method thereof.

二、背景技术2. Background Technology

随着疾病谱的转变，慢性非传染性疾病已逐减成为疾病负担及影响经济发展的一个重要因素，但传染病仍然是一个重要的公共卫生问题。新发传染病的不断出现给人类带来了新的严重威胁，近30年来全球约出现新发传染病40多种，并以每年新发1种的态势发展，其传播范围广、传播速度快、社会危害影响大，如非典型性肺炎(SARS)、中东呼吸综合征(MERS)、甲型H1N1流感、H7N9禽流感、寨卡病毒(ZikaVirus)、埃博拉病毒(EbolaVirus)，已经成为全球公共卫生中的重点和热点问题。With the change of the disease spectrum, chronic non-communicable diseases have gradually become an important factor affecting the disease burden and economic development, but infectious diseases are still an important public health issue. The continuous emergence of new infectious diseases has brought new and serious threats to mankind. In the past 30 years, more than 40 new infectious diseases have appeared in the world, and one new infectious disease has emerged every year. They spread widely, spread quickly, and have great social harm. For example, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), influenza A (H1N1), avian influenza H7N9, Zika virus (ZikaVirus), Ebola virus (EbolaVirus) have become the focus and hot issues in global public health.

中医药防治“疫病”历史悠久，积累了经验丰富经验。中国至少已有3500年以上的疫情历史，早在商代的甲骨文中就有“疫”的记载。中医一般将传染病称之为“疫病”、“瘟疫”、“伤寒”、“外感热病”或“温病”。传染病在我国自古有之，且危害不小。据记载，自西汉至今，我国先后发生过300多次传染病流行。翻开中医药历史，我们会发现我国几千年来与瘟疫的对抗中，形成了系统的中医药防疫理论。从《黄帝内经》“五疫”的记载到汉代张仲景《伤寒论》对“伤寒”患者的症状、脉象、症候以及治疗验方等的经验总结，再到晋代医学家葛洪的《肘后备急方》用“疠气”来解释病因和创造性地提出用青蒿治疗疟疾以及明代吴有性著作《温疫论》，对温疫病因、特点及其辨证论治提出了创新性贡献。中医药因多次抗击瘟疫而不断总结经验、推陈出新，形成了传承至今的中医药抗疫理论，积累了丰富的传染病辨证论治经验。Traditional Chinese medicine has a long history of preventing and treating "epidemic diseases" and has accumulated rich experience. China has a history of epidemics for at least 3,500 years, and there are records of "epidemics" as early as the oracle bone inscriptions of the Shang Dynasty. Traditional Chinese medicine generally refers to infectious diseases as "epidemic diseases", "plague", "typhoid fever", "exogenous febrile diseases" or "warm diseases". Infectious diseases have existed in my country since ancient times, and they are not small. According to records, more than 300 epidemics of infectious diseases have occurred in my country since the Western Han Dynasty. Looking back at the history of traditional Chinese medicine, we will find that in the fight against plagues in my country for thousands of years, a systematic theory of traditional Chinese medicine epidemic prevention has been formed. From the record of "five epidemics" in "Huangdi Neijing" to the experience summary of the symptoms, pulse, symptoms and treatment prescriptions of "typhoid fever" patients in "Treatise on Febrile Diseases" by Zhang Zhongjing in the Han Dynasty, to the Jin Dynasty medical scientist Ge Hong's "Emergency Prescriptions for the Elbow" using "pestilent air" to explain the cause of the disease and creatively proposed the use of Artemisia annua to treat malaria, as well as Wu Youxing's book "Treatise on Warm Epidemics" in the Ming Dynasty, innovative contributions have been made to the cause, characteristics and syndrome differentiation and treatment of warm epidemics. Traditional Chinese medicine has continuously summed up experience and innovated in its fight against epidemics, forming the theory of traditional Chinese medicine anti-epidemic that has been passed down to this day, and has accumulated rich experience in the diagnosis and treatment of infectious diseases.

中医早在2000年前就对人类外感病发病有了深刻认识，《素问遗篇·刺法论》曰：“正气存内，邪不可干”，其意是只要人体正气存在，病邪就不会侵犯到机体而引起疾病；《素问·评热病论》曰：“邪之所腠，其气必虚”，其意是只要疾病发生就说明机体正气虚弱，为此，治疗外感病的基本原则是扶正固本祛邪。通过扶助正气，增强人体抗病能力，以祛除病邪，促进生理机能的恢复，从而达到治愈疾病的目的。中医所说的正气与现代医学的免疫密切相关。现代免疫学认为，免疫是机体识别和排除抗原性异物的一种功能，其目的是维护机体的生理平衡。免疫系统具有免疫防御、免疫稳定、免疫监视等多种功能。外感病和或传染性疾病的易感人群，多是免疫力低下、年老体弱或伴有其他疾病的机体抵抗力较差的人群。As early as 2,000 years ago, Chinese medicine had a profound understanding of the onset of human exogenous diseases. "Suwen Yipian·Acupuncture Theory" said: "When the righteousness is inside, the evil cannot invade", which means that as long as the righteousness of the human body exists, the pathogenic factors will not invade the body and cause disease; "Suwen·Comment on Rebates" said: "Where the evil enters the skin, the qi must be weak", which means that as long as the disease occurs, it means that the body's righteousness is weak. Therefore, the basic principle of treating exogenous diseases is to strengthen the body and eliminate the evil. By supporting the righteousness, the body's disease resistance is enhanced, the pathogenic factors are eliminated, and the recovery of physiological functions is promoted, so as to achieve the purpose of curing the disease. The righteousness mentioned in Chinese medicine is closely related to immunity in modern medicine. Modern immunology believes that immunity is a function of the body to recognize and eliminate antigenic foreign bodies, and its purpose is to maintain the body's physiological balance. The immune system has multiple functions such as immune defense, immune stability, and immune surveillance. The susceptible population of exogenous diseases and/or infectious diseases is mostly people with low immunity, the elderly and weak, or people with other diseases with poor body resistance.

本发明以中医“正气存内，邪不可干”，“邪之所腠，其气必虚”理论为指导，提出针对外感病和或传染性疾病的易感人群防治，以扶正固本祛邪为治则，通过现代药理筛选优化组方，制备而成，用于免疫力低下、年老体弱或伴有其他疾病的机体抵抗力下降的易感人群预防外感病和或传染性疾病。本发明技术原创性在于针对外感病和或传染性疾病发病为正气亏虚的基本病机，将正虚与免疫相结合，组方君药黄芪，补益肺气、益卫固表，防治毒邪侵入，现代药理研究表明黄芪能增強和调节机体免疫功能，对干扰素系统有促进作用，可提高机体的抗病力；对流感病毒等多种病毒所致细胞病变有抑製作用，有较广泛的抗菌作用。臣药白术健脾益气，现代药理研究表明白术能促进细胞免疫功能，提升白细胞，抗菌，保肝作用；五味子益肾补气，现代药理研究表明能增強机体对非特异性刺激的防禦能力，增加细胞免疫功能，提高免疫，抗氧化、抗衰老作用，对金色葡萄球菌、肺炎桿菌、肠道沙门氏菌、绿脓桿菌等均有抑製作用。共助君药补气益卫固表。佐药防风祛风解表，抵御外邪，现代药理研究表明防风解热、抗炎、抗过敏作用，并有增強小鼠腹腔巨噬细胞吞噬功能的作用；金银花清热解毒，现代药理研究表明金银花具有广谱抗菌作用，能促进白细胞的吞噬作用，有明显的抗炎及解热作用，对金黄色葡萄球菌、痢疾桿菌等致病菌有较強的抑製作用，对钩端螺旋体、流感病毒及致病黴菌等多种病原微生物亦有抑製作用；连翘清热解毒，现代药理研究表明连翘有广谱抗菌作用，对金黄色葡萄球菌、痢疾桿菌有很強的抑製作用，对其他致病菌、流感病毒以及钩端螺旋体也均有一定的抑製作用，并有抗炎、解热作用；板蓝根清热解毒、凉血利咽，现代药理研究表明板蓝根对多种革兰氏阳性菌、革兰氏阴性菌及流感病毒、虫媒病毒、腮腺病毒均有抑製作用，可增強免疫功能，有明显的解热、抗氧化作用；鱼腥草清热解毒，现代药理研究表明鱼腥草素对金黄色葡萄球菌、肺炎双球菌、甲型链球菌、流感桿菌、卡他球菌、伤寒桿菌以及结核桿菌等多种革兰氏阳性及阴性细菌，均有不同程度的抑製作用，能增強白细胞吞噬能力，提高机体免疫力，並有抗炎作用；芦根清热泻火，可清透肺热止咳，现代药理研究表明芦根有解热、镇静、镇痛、抗氧化，对β-溶血链球菌有抑製作用；天花粉清热泻火，既能泻火以清肺热，又能生津以润肺燥，治燥热伤肺，干咳少痰、痰中带血等肺热燥咳证，现代药理研究表明天花粉蛋白可抑制艾滋病病毒(HIV)在感染的免疫细胞内的複製繁衍，减少免疫细胞中受病毒感染的活细胞数，能抑制HIV的DNA複製和蛋白质合成；桔梗宣肺、祛痰、利咽，保护上呼吸道，现代药理研究表明具有增強巨噬细胞的吞噬功能，提高溶菌酶活性，增強中性白细胞的杀菌力，增強抗炎和免疫作用，共助君药扶正祛邪。使药甘草补中益气，清热解毒，调和诸药，现代药理研究表明甘草有抗菌、抗病毒、抗炎、抗过敏作用；能保护咽喉和气管粘膜。诸药合用，共凑益气固表、清热解毒、清肺利咽。The present invention is guided by the theories of traditional Chinese medicine that "positive energy exists inside, and evil cannot interfere" and "where evil enters the skin, its energy must be weak", and proposes prevention and treatment of susceptible populations for exogenous diseases and/or infectious diseases, with strengthening the body and eliminating evil as the treatment principle, and is prepared by modern pharmacological screening and optimization of the formula, and is used for the prevention of exogenous diseases and/or infectious diseases in susceptible populations with low immunity, old and weak bodies, or decreased body resistance accompanied by other diseases. The technical originality of the present invention lies in targeting the basic pathogenesis of the onset of exogenous diseases and/or infectious diseases as positive energy deficiency, combining positive energy deficiency with immunity, formulating the main drug astragalus, replenishing lung qi, strengthening the body's defense and exterior, and preventing and treating the invasion of toxic evil. Modern pharmacological studies have shown that astragalus can enhance and regulate the body's immune function, promote the interferon system, and improve the body's disease resistance; it has an inhibitory effect on cell lesions caused by various viruses such as influenza virus, and has a relatively wide range of antibacterial effects. The assistant drug Atractylodes macrocephala can strengthen the spleen and replenish qi. Modern pharmacological studies have shown that Atractylodes macrocephala can promote cellular immune function, increase white blood cells, and has antibacterial and liver-protecting effects. Schisandra chinensis can strengthen the kidney and replenish qi. Modern pharmacological studies have shown that it can enhance the body's defense against nonspecific stimuli, increase cellular immune function, improve immunity, and has anti-oxidation and anti-aging effects. It has an inhibitory effect on Staphylococcus aureus, Pneumococcus, Salmonella enterica, Pseudomonas aeruginosa, etc. Together, they help the main drug to replenish qi, benefit the body's defense system, and consolidate the exterior. The adjuvant drug Saposhnikovia dispels wind and relieves exterior symptoms, resists external pathogens, and modern pharmacological studies have shown that Saposhnikovia has antipyretic, anti-inflammatory, and anti-allergic effects, and can enhance the phagocytic function of mouse peritoneal macrophages; Honeysuckle clears heat and detoxifies, and modern pharmacological studies have shown that Honeysuckle has a broad-spectrum antibacterial effect, can promote the phagocytosis of leukocytes, has obvious anti-inflammatory and antipyretic effects, has a strong inhibitory effect on pathogenic bacteria such as Staphylococcus aureus and Shigella dysenteriae, and also has an inhibitory effect on a variety of pathogenic microorganisms such as Leptospira, influenza virus and pathogenic fungi; Forsythia clears heat and detoxifies, modern pharmacological studies have shown that Honeysuckle has a broad-spectrum antibacterial effect, can promote the phagocytosis of leukocytes, has obvious anti-inflammatory and antipyretic effects, and has a strong inhibitory effect on pathogenic bacteria such as Staphylococcus aureus and Shigella dysenteriae. It also has an inhibitory effect on a variety of pathogenic microorganisms such as Leptospira, influenza virus and pathogenic fungi; Studies have shown that Forsythia has a broad-spectrum antibacterial effect, and has a strong inhibitory effect on Staphylococcus aureus and Shigella dysenteriae. It also has a certain inhibitory effect on other pathogenic bacteria, influenza virus and Leptospira, and has anti-inflammatory and antipyretic effects; Isatis root clears heat and detoxifies, cools blood and relieves sore throat. Modern pharmacological studies have shown that Isatis root has an inhibitory effect on a variety of Gram-positive bacteria, Gram-negative bacteria, influenza virus, arbovirus, and mumps virus, can enhance immune function, and has obvious antipyretic and antioxidant effects; Houttuynia cordata clears heat and detoxifies. Modern pharmacological studies have shown that Houttuynia cordata Herba Lycopersicum has different degrees of inhibitory effect on various Gram-positive and -negative bacteria such as Staphylococcus aureus, Pneumococcus, Group A Streptococcus, influenza bacillus, catarrhalis, typhoid bacillus and tuberculosis. It can enhance the phagocytic ability of leukocytes, improve the body's immunity and has anti-inflammatory effect. Phragmites australis can clear away heat and purge fire, clear lung heat and relieve cough. Modern pharmacological research shows that Phragmites australis has antipyretic, sedative, analgesic and antioxidant effects, and has an inhibitory effect on β-hemolytic streptococci. Radix Trichosanthis can clear away heat and purge fire, which can purge fire to clear lung heat and produce body fluid to moisten lung dryness, and treat dryness. Heat damages the lungs, causing dry coughs with little sputum and blood in the sputum. Modern pharmacological studies have shown that trichosanthes protein can inhibit the replication and reproduction of HIV in infected immune cells, reduce the number of live cells infected by the virus in immune cells, and inhibit HIV DNA replication and protein synthesis; Platycodon grandiflorum can clear the lungs, eliminate phlegm, and relieve sore throat, protecting the upper respiratory tract. Modern pharmacological studies have shown that it can enhance the phagocytic function of macrophages, increase the activity of lysozyme, enhance the bactericidal power of neutrophils, enhance anti-inflammatory and immune effects, and help the main medicine to strengthen the body and eliminate evil. Licorice is a supporting medicine that replenishes the middle qi, clears heat and detoxifies, and harmonizes the various medicines. Modern pharmacological studies have shown that licorice has antibacterial, antiviral, anti-inflammatory, and anti-allergic effects; it can protect the throat and tracheal mucosa. The combination of various medicines can replenish qi and consolidate the exterior, clear heat and detoxify, and clear the lungs and relieve sore throat.

本发明与现有扶正固本相关专利技术比较。经以“扶正固本”为主题词检索中国知网专利库，涉及扶正固本组合物专利申请共31项，去掉外观专利、多次公布重复专利外，还有22项，在22项中组方均与本发明组方明显不同，具体如下：(1)申请(专利)号：CN202210363648.X一种可以扶正固本的中药组合物及其制作方法，其特征在于，包括如下成分：苦参，女贞子，墨旱莲，龙骨(生)，牡蛎(生)，黄芪，人参须，麦冬，草豆蔻粉，五味子，灵磁石。(2)申请(专利)号：CN202010196388.2，一种具有扶正固本，补肝益肾，增强免疫功效的中药组合物，其特征在于：所述中药组合物由以下重量份数的原料药制备而成：淫羊藿、女贞子、黄芪、党参、当归、制何首乌、丹参、炙甘草、茯苓、枸杞子。(3)申请(专利)号：CN201910653151.X，一种保扶正固本中药组合物，其特征在于，包括以下重量份数的各组分：黄芪、柴胡、枳壳、白芍、仙鹤草、灵芝、红景天、虫草、党参、白术、茯苓、茯苓、女贞子、炙甘草、川芎、紫河车、焦山楂、焦麦芽。(4)申请(专利)号：CN201811064501.0，一种扶正固本抗癌中药制剂，其特征在于，由以下重量份原料制成：黄芪、当归、西洋参、炒白术、白芍、黄精、熟地黄、生地黄、山萸肉、山药、茯苓、泽泻、牡丹皮、重楼、猫爪草、山慈菇、三七、白花蛇舌草、半枝莲、白英、龙葵、夏枯草、鹿角、鳖甲、牡蛎、桂枝、赤芍、桃仁、三棱、莪术、柴胡、制半夏、黄连、黄芩、甘草、蒲公英。(5)申请(专利)号：CN201811632937.5，一种气阴双补、扶正固本的食药两用组合物，其特征在于，其有效成分由以下重量份数的原料制备而成：桂圆、枸杞子、山药、黄精、玫瑰花、桑葚、大枣、甘草。(6)申请(专利)号：CN201410117738.6，一种复合真菌多糖制剂，由以下重量百分比的原料制成：灰树花多糖、猴头菇多糖、灵芝多糖、茯苓多糖。(7)申请(专利)号：CN201410172346.X，一种用于治疗食管癌、胃癌、肺癌、乳腺癌、卵巢癌、宫颈癌、头颈部癌以及增强机体免疫、提高癌症患者生活质量的扶正固本颗粒，其特征在于它是由下述重量配比的原料制成的：黄芩、淫羊藿、女贞子、何首乌、地黄、茜草、黄精、人参。(8)申请(专利)号：CN201410485800.7，一种扶正固本益气安神的制剂，其特征在于：由按重量份计的如下组分制备而成：人参、灵芝、蜂蜜、淀粉适量。(9)申请(专利)号：CN201210219176.7，一种扶正固本的中药，其特征在于，它是由以下重量配比的药材制备而成：冬虫夏草、薏苡仁、茯苓、当归、柴胡、灵芝、生地黄、人参、白芍、山药、赤小豆、大枣。(10)申请(专利)号：CN201310110672.3，扶正固本颗粒的质量控制方法，所述扶正固本颗粒是由以下原料药制备而成的药物：黄芩、女贞子、淫羊藿、何首乌、地黄、黄精、茜草、人参。(11)申请(专利)号：CN201210151089.2，一种扶正固本适于糖尿病患者饮用的保健饮料，其特征在于，它是由以下重量份的原料制成：鹰嘴豆、虫草素、甜菊糖、纯净水。(12)申请(专利)号：CN201110119811.X，一种具有扶正固本、增强人体免疫力、抗疲劳、抗肿瘤、延缓衰老作用的中药组合物，其特征在于该组合物的原料药组成为：蝙蝠蛾拟青霉菌丝体、灵芝、破壁灵芝孢子粉、西洋参。(13)申请(专利)号：CN201110175461.9，一种具有扶正固本、增强人体免疫力、抗疲劳、抗肿瘤、延缓衰老作用的中药组合物，其特征在于该组合物由如下方法制成：蝙蝠蛾拟青霉菌丝体、灵芝、破壁灵芝孢子粉、西洋参。(14)申请(专利)号：CN201110386796.5，一种用于治疗食管癌、胃癌、肺癌、乳腺癌、卵巢癌、宫颈癌、头颈部癌以及增强机体免疫、提高癌症患者生活质量的扶正固本颗粒，其特征在于它是由下述重量配比的原料制成的：黄芩、淫羊藿、女贞子、何首乌、地黄、茜草、黄精、人参。(15)申请(专利)号：CN200710090867.0，一种用于癌症病人放化疗过程中扶正固本的药物，其特征在于，它是由下述重量配比的原料药制作的：黄芪、麦冬、西洋参、去核山茱萸、枸杞子、炙香附。(16)申请(专利)号：CN200810101889.7，一种扶正固本、清热解毒的中药组合，其特征是由药效成分和/或药学上可接受的载体组成，其中所述的药效成分是由下列原料制成的：土茯苓、大青叶、延胡索、制乳香、没药、忍冬藤、当归、丹参、炙甘草、柴胡、炒枳实、桑寄生、菟丝子。(17)申请(专利)号：CN200810181011.9，一种具有补肾壮阳、扶正固本功效的中药，其特征在于它主要是由下列重量配比的原料制成的药剂：枸杞子、熟地黄、菟丝子、淫羊藿、肉苁蓉、人参、灵芝草、拟黑多刺蚂蚁、蜂花粉。(18)申请(专利)号：CN200610065615.8，一种具有解毒化瘀，扶正固本功效，可用于肺癌、肝癌、胃癌化疗合并用药的中药复方制剂，其特征在于，由下述重量比例的中药原料制成：虎眼万年青、半枝莲、虎杖、郁金、白花蛇舌草、人参、丹参、黄芪、全蝎、蜈蚣。(19)申请(专利)号：CN200410062488.7，一种补益心肾二气、辅以活血化瘀以治疗前列腺增生、前列腺炎、性功能减退、更年期综合症、冠心病、脑血栓、慢性疲劳症、神经衰弱、记忆力减退、老年性痴呆症和免疫功能低下或失调引起疾病的组合物，由以下重量配比的原料制成任何剂型的药品或保健食品：人参、黄芪、沙棘、枸杞子、淫羊藿、三七、五味子，或原料组成有以下变化中的一种：(1)在组合物中增加覆盆子，用量为1-24g；(2)用等量西洋参替代人参；(3)用等量川芎或丹参替代三七；或(4)用等量覆盆子替代枸杞子。(20)申请(专利)号：CN202010105076.6，一种扶正固本提高免疫力防控疫毒的功能饮料，其特征在于：它由下述重量份数原料制成的制品：中药的配方人参、蛹虫草、阿胶、枸杞子、桑椹子、山药、益智仁、黄精、龙眼肉、茯苓、百合、金银花、沙棘、茶树花、枳椇子、麦芽、山楂、甘草、罗汉果、针叶樱桃果。(21)申请(专利)号：CN202010105027.2，一种扶正固本提高免疫力防控疫毒的功能面粉，其特征在于：它由下述重量份数原料制成的制品：全麦粉、玉米胚芽粉、人参、蛹虫草、阿胶、枸杞子、桑椹子、山药、黄精、茯苓、百合、金银花、沙棘、茶树花、麦芽、甘草。该发明针对人群是适宜年老、体弱、免疫力低下的瘟疫易感人群，以及肺肾气虚之长期咳喘、多汗、平素易感冒群体，或肝肾亏虚、须发早白、毛发枯槁、易脱发、智力减退或老年痴呆者，或虚劳失眠、熬夜劳目、眼涩抽筋、指甲扁平粗糙、肝血亏虚之人，或身体羸弱、易疲困倦、脾胃失运气血亏虚群体。(22)申请(专利)号：CN201711377355.2，一种扶正固本、提高免疫力的食品、保健品或药物组合物，其特征在于：它是由下述重量配比的原料制备而成的制剂：人参、黄精、甘草、红茶。The present invention is compared with the existing patent technologies related to strengthening the body. After searching the CNKI patent database with "strengthening the body" as the keyword, there are 31 patent applications involving strengthening the body composition. Excluding appearance patents and duplicate patents published many times, there are 22 patents. The formulas in the 22 patents are obviously different from the formulas of the present invention, as follows: (1) Application (patent) number: CN202210363648.X A Chinese medicine composition that can strengthen the body and strengthen the body and a preparation method thereof, characterized in that it includes the following ingredients: Sophora flavescens, Ligustrum lucidum, Eclipta prostrata, Dragon bone (raw), Oyster (raw), Astragalus, Ginseng root, Ophiopogon japonicus, Cardamom powder, Schisandra chinensis, Magnetite. (2) Application (patent) number: CN202010196388.2, a Chinese medicine composition with the effects of strengthening the body, nourishing the liver and kidney, and enhancing immunity, characterized in that the Chinese medicine composition is prepared from the following raw materials in parts by weight: epimedium, Ligustrum lucidum, Astragalus, Codonopsis pilosula, Angelica sinensis, Polygonum multiflorum processed, Salvia miltiorrhiza, Radix glycyrrhizae, Poria, and Lycium barbarum. (3) Application (patent) number: CN201910653151.X, a Chinese medicine composition for strengthening the body, characterized in that it includes the following components in parts by weight: Astragalus, Bupleurum, Citrus aurantium, White Peony, Agrimoniae, Ganoderma lucidum, Rhodiola rosea, Cordyceps sinensis, Codonopsis pilosula, Atractylodes macrocephala, Poria, Poria, Ligustrum lucidum, Radix glycyrrhizae, Ligustrum lucidum, Rhizoma chuanxiong, Placenta, Charred Crataegus pinnatifida, and Charred Malt. (4) Application (patent) number: CN201811064501.0, a Chinese medicine preparation for strengthening the body and resisting cancer, characterized in that it is made of the following raw materials in parts by weight: astragalus, angelica, American ginseng, stir-fried atractylodes, white peony root, polygonatum, prepared rehmannia root, raw rehmannia root, cornus fruit, yam, tuckahoe, oriental water plantain, peony bark, parsley, cat's claw, trillium, notoginseng, oldenlandia diffusa, Scutellaria barbata, white safflower, solanum nigrum, selfhealing herb, antler, turtle shell, oyster, cassia twig, red peony root, peach kernel, three-edged atractylodes, curcuma, bupleurum, processed pinellia, coptis root, scutellaria baicalensis, liquorice, dandelion. (5) Application (patent) number: CN201811632937.5, a food and medicine dual-purpose composition for replenishing both qi and yin, strengthening the body, characterized in that its active ingredients are prepared from the following raw materials in parts by weight: longan, wolfberry, yam, polygonatum, rose, mulberry, jujube, and licorice. (6) Application (patent) number: CN201410117738.6, a composite fungal polysaccharide preparation, prepared from the following raw materials in parts by weight: maitake mushroom polysaccharide, hericium erinaceus polysaccharide, ganoderma lucidum polysaccharide, and tuckahoe polysaccharide. (7) Application (patent) number: CN201410172346.X, a granule for strengthening the body and improving the quality of life of cancer patients for the treatment of esophageal cancer, gastric cancer, lung cancer, breast cancer, ovarian cancer, cervical cancer, head and neck cancer, and for enhancing the body's immunity and improving the quality of life of cancer patients, characterized in that it is made of the following raw materials in weight ratio: scutellaria baicalensis, epimedium, Ligustrum lucidum, Polygonum multiflorum, Rehmannia root, Rubia cordifolia, Polygonatum sibiricum, ginseng. (8) Application (patent) number: CN201410485800.7, a preparation for strengthening the body and strengthening the body, characterized in that it is made of the following components in weight ratio: ginseng, ganoderma lucidum, honey, and starch in appropriate amounts. (9) Application (patent) number: CN201210219176.7, a Chinese medicine for strengthening the body, characterized in that it is prepared from the following medicinal materials in weight proportion: cordyceps sinensis, coix seed, poria, angelica, bupleurum, ganoderma lucidum, raw rehmannia root, ginseng, white peony root, yam, red bean, jujube. (10) Application (patent) number: CN201310110672.3, a quality control method for strengthening the body granules, the said strengthening the body granules are a medicine prepared from the following raw materials: scutellaria baicalensis, fructus privet, epimedium, polygonum multiflorum, rehmannia root, polygonatum sibiricum, madder, ginseng. (11) Application (patent) number: CN201210151089.2, a health drink for strengthening the body suitable for diabetic patients, characterized in that it is made from the following raw materials in weight proportion: chickpea, cordycepin, stevioside, purified water. (12) Application (patent) number: CN201110119811.X, a Chinese medicine composition with the effects of strengthening the body, enhancing human immunity, anti-fatigue, anti-tumor, and delaying aging, characterized in that the raw materials of the composition are: mycelium of Paecilomyces pyralis, Ganoderma lucidum, broken wall Ganoderma lucidum spore powder, and American ginseng. (13) Application (patent) number: CN201110175461.9, a Chinese medicine composition with the effects of strengthening the body, enhancing human immunity, anti-fatigue, anti-tumor, and delaying aging, characterized in that the composition is made by the following method: mycelium of Paecilomyces pyralis, Ganoderma lucidum, broken wall Ganoderma lucidum spore powder, and American ginseng. (14) Application (patent) number: CN201110386796.5, a granule for strengthening the body and improving the quality of life of cancer patients for the treatment of esophageal cancer, gastric cancer, lung cancer, breast cancer, ovarian cancer, cervical cancer, head and neck cancer, and for enhancing the body's immunity, characterized in that it is made of the following raw materials in weight ratio: scutellaria, epimedium, Ligustrum lucidum, Polygonum multiflorum, Rehmannia root, Rubia cordifolia, Polygonatum sibiricum, ginseng. (15) Application (patent) number: CN200710090867.0, a drug for strengthening the body and strengthening the body during radiotherapy and chemotherapy for cancer patients, characterized in that it is made of the following raw materials in weight ratio: astragalus, ophiopogon, American ginseng, de-seed cornus officinalis, wolfberry, roasted cyperus. (16) Application (patent) number: CN200810101889.7, a Chinese medicine combination for strengthening the body and clearing away heat and detoxifying, characterized by being composed of active ingredients and/or pharmaceutically acceptable carriers, wherein the active ingredients are made from the following raw materials: Rhizoma Smilacis Glabrae, Folium Isatidis, Rhizoma Corydalis, Olibanum, Myrrh, Caulis Loniceraes, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Radix Bupleuri, Stir-fried Fructus Aurantii Immaturus, Herba Mori Parasiticae, and Semen Cuscutae. (17) Application (patent) number: CN200810181011.9, a Chinese medicine for strengthening the kidney and strengthening the yang, and strengthening the body and strengthening the body, characterized by being mainly made from the following raw materials in weight ratio: Fructus Lycii, Radix Rehmanniae Preparata, Fructus Cuscutae, Herba Epimedii, Herba Cistanches, Ginseng, Herba Ganodermae Lucidum, Pseudo-Black Prickly Ants, and Bee Pollen. (18) Application (patent) number: CN200610065615.8, a Chinese medicine compound preparation having the effects of detoxifying, removing blood stasis, strengthening the body and consolidating the constitution, which can be used for combined chemotherapy for lung cancer, liver cancer and gastric cancer, characterized in that it is made of the following Chinese medicine raw materials in the following weight proportions: Ornithogalum, Scutellaria barbata, Polygonum cuspidatum, Curcuma aromatica, Hedyotis diffusa, Ginseng, Salvia miltiorrhiza, Astragalus, Scorpio and Centipede. (19) Application (patent) number: CN200410062488.7, a composition for tonifying the heart and kidney qi and assisting in promoting blood circulation and removing blood stasis to treat prostatic hyperplasia, prostatitis, sexual dysfunction, menopausal syndrome, coronary heart disease, cerebral thrombosis, chronic fatigue, neurasthenia, memory loss, senile dementia and diseases caused by low immune function or imbalance, made of the following raw materials in a weight ratio to form a medicine or health food in any dosage form: ginseng, astragalus, seabuckthorn, wolfberry, epimedium, Panax notoginseng, Schisandra chinensis, or the raw material composition has one of the following changes: (1) adding raspberry to the composition, the amount of which is 1-24g; (2) replacing ginseng with an equal amount of American ginseng; (3) replacing Panax notoginseng with an equal amount of Chuanxiong or Salvia miltiorrhiza; or (4) replacing wolfberry with an equal amount of raspberry. (20) Application (patent) number: CN202010105076.6, a functional beverage for strengthening the body, improving immunity and preventing and controlling epidemics, characterized in that it is a product made of the following raw materials in parts by weight: a Chinese medicine formula of ginseng, cordyceps militaris, donkey-hide gelatin, wolfberry, mulberry, yam, alpinia oxyphylla, polygonatum, longan pulp, tuckahoe, lily, honeysuckle, sea buckthorn, tea tree flower, Hovenia dulcis, malt, hawthorn, licorice, monk fruit, acerola fruit. (21) Application (patent) number: CN202010105027.2, a functional flour for strengthening the body, improving immunity and preventing and controlling epidemics, characterized in that it is a product made of the following raw materials in parts by weight: whole wheat flour, corn germ powder, ginseng, cordyceps militaris, donkey-hide gelatin, wolfberry, mulberry, yam, polygonatum, tuckahoe, lily, honeysuckle, sea buckthorn, tea tree flower, malt, licorice. The invention is suitable for the elderly, weak, and immunocompromised people who are susceptible to plague, as well as people with long-term cough and asthma, sweating, and catching colds due to lung and kidney qi deficiency, or people with liver and kidney deficiency, premature graying of hair, dry hair, easy hair loss, mental decline or Alzheimer's disease, or people with insomnia, staying up late, eye strain, cramps, flat and rough nails, liver blood deficiency, or people with weak bodies, easy fatigue, spleen and stomach qi and blood deficiency. (22) Application (patent) number: CN201711377355.2, a food, health product or pharmaceutical composition for strengthening the body and improving immunity, characterized in that it is a preparation made from the following raw materials in weight ratio: ginseng, polygonatum, licorice, and black tea.

经以“中药”“新冠”为主题词检索中国知网专利库，涉及防治新型冠状病毒感染的中药组合物专利申请共10项，在10项中组方均与本发明组方明显不同的有8项，具体如下：(1)申请(专利)号：CN202210356124.8，一种用于预防新冠病毒的中药组合物，其特征在于，包括以下重量份数的原料：雄黄、鬼箭羽、丹参、赤小豆、黑大豆、乌梅、紫菀、芍药、黄芩、细辛、知母和桂心。(2)申请(专利)号：CN202111630377.1，一种对新冠病毒具有疗效的中药组合及其制备方法，其技术方案要点是：包括以下组分：白芷油、辛夷油、厚朴油、陈皮油、板蓝根、升麻、广藿香油、黄连。(3)申请(专利)号：CN202110572543.0，一种预防新冠病毒的中药药物及其制备方法，其特征在于，按照重量份数计，包括：荆芥、防风、柴胡、川芎、贯众、羌活、黄莲、黄芩、茯苓、鸡内金、枳壳、法半夏、信前胡、薄荷、青蒿。(4)申请(专利)号：CN202110199971.3，治疗新冠病毒风寒表虚症的中药组合物及其制备方法，其特征在于，是由下列材料按照质量比例份数制备而成：桂枝、芍药、炙甘草、青蒿粉、栀子、桔梗和沙参。(5)申请(专利)号：CN202011500278.7，一种预防新冠病毒的中药组合物及制备方法和应用，其特征在于：该中药组合物包括以下重量份的中药原料：苍术、桂枝、砂仁、艾叶、丁香、川芎、麻黄、香茅草、细辛、白术、白豆蔻、石菖蒲、干姜、白花蛇舌草、蛇床子、白芷、防风、荆芥、冰片、板蓝根、广藿香油、佩兰挥发油。(6)申请(专利)号：CN202010372164.2，一种防治新型冠状病毒感染的中药组合物及其制备方法与用途，其特征在于，所述的中药组合物的药物活性成分由麻黄、薏苡仁、杏仁、紫菀、款冬花、生石膏、厚朴、知母、白芍、黄芩、炙甘草、白芥子、苏子、莱菔子、金荞麦、黄芪、百合组成的混合物。(7)申请(专利)号：CN202010461885.0，一种治疗新冠病毒和病毒性疾病的中药制剂及制备方法，其特征在于，所述中药制剂，包括以下重量的中药原料：炙麻黄、杏仁、金银花、石膏、生姜、苍术、白花蛇草、枳壳、茯苓、大枣、神曲、防风、大黄、桂枝、桔梗、川穹、荆芥、白术、炙甘草。(8)申请(专利)号：CN202110200022.2，治疗新冠病毒侵袭腠理的中药组合物及其制备方法，其特征在于，是由下列材料按照质量比例份数混合而成：桔梗、金银花、薏苡仁、黄芩、炙黄芪、川贝母、陈皮、青蒿粉、白芨、炒甜葶苈和甘草节。By searching the CNKI patent database with the keywords "traditional Chinese medicine" and "new crown", there are 10 patent applications involving traditional Chinese medicine compositions for preventing and treating novel coronavirus infection. Among the 10 applications, 8 applications have formulations that are significantly different from the formulation of the present invention, as follows: (1) Application (patent) number: CN202210356124.8, a traditional Chinese medicine composition for preventing novel coronavirus, characterized in that it comprises the following raw materials in parts by weight: realgar, radix ophiopogonis, salvia miltiorrhiza, adzuki bean, black soybean, ebony, aster, peony, scutellaria baicalensis, asarum, rhizoma anemarrhenae and cinnamon bark. (2) Application (patent) number: CN202111630377.1, a traditional Chinese medicine composition with therapeutic effects on novel coronavirus and its preparation method, the main points of its technical solution are: comprising the following components: angelica root oil, magnolia oil, magnolia bark oil, tangerine peel oil, isatis root, cimicifuga heracleifolia, patchouli oil, coptis root. (3) Application (patent) number: CN202110572543.0, a Chinese medicine for preventing COVID-19 and its preparation method, characterized in that, by weight, it includes: Nepeta, Saposhnikovia, Bupleurum, Chuanxiong, Guanzhong, Notopterygium, Rhizoma Coptidis, Radix Scutellariae, Poria, Gallus gallus domestica, Fructus Aurantii Immaturus, Pinellia ternata, Peucedanum pekinensis, Mentha, Artemisia annua. (4) Application (patent) number: CN202110199971.3, a Chinese medicine composition for treating COVID-19 wind-cold deficiency syndrome and its preparation method, characterized in that it is prepared from the following materials by weight: cinnamon twig, peony root, licorice root, artemisia annua powder, gardenia, platycodon and adenophora. (5) Application (patent) number: CN202011500278.7, a Chinese medicine composition for preventing the new coronavirus, and its preparation method and application, characterized in that: the Chinese medicine composition comprises the following Chinese medicine raw materials in parts by weight: Atractylodes lancea, cinnamon twig, Amomum villosum, Artemisia argyi, clove, Ligusticum chuanxiong, Ephedra, Cymbopogon citratus, Asarum, Atractylodes macrocephala, White cardamom, Acorus calamus, dried ginger, Hedyotis diffusa, Cnidium monnieri, Angelica dahurica, Saposhnikovia diffusa, Nepeta tenuifolia, borneol, Isatis indigotica, Patchouli oil, and Perilla frutescens volatile oil. (6) Application (patent) number: CN202010372164.2, a Chinese medicine composition for preventing and treating novel coronavirus infection and its preparation method and use, characterized in that the active pharmaceutical ingredients of the Chinese medicine composition are a mixture of ephedra, coix seed, apricot, aster, coltsfoot flower, gypsum, magnolia bark, rhubarb, white peony root, scutellaria baicalensis, roasted licorice, white mustard seed, perilla seed, radish seed, golden buckwheat, astragalus, and lily. (7) Application (patent) number: CN202010461885.0, a Chinese medicine preparation for treating novel coronavirus and viral diseases and its preparation method, characterized in that the Chinese medicine preparation comprises the following Chinese medicine raw materials by weight: roasted ephedra, apricot, honeysuckle, gypsum, ginger, atractylodes, white snake grass, fructus aurantii, poria, jujube, Shenqu, siler, rhubarb, cassia twig, platycodon, chuanxiong, schizonepeta, atractylodes, and roasted licorice. (8) Application (patent) number: CN202110200022.2, a Chinese medicine composition for treating novel coronavirus invading the skin and a preparation method thereof, characterized in that the composition is a mixture of the following materials in proportion by mass: Platycodon grandiflorum, honeysuckle, coix seed, scutellaria baicalensis, roasted astragalus, fritillaria cirrhosa, tangerine peel, artemisia annua powder, bletilla striata, stir-fried sweet sedge and liquorice node.

含有本发明5种以上原料的仅有2项，与本发明比较，不同之处在于：(1)申请(专利)号：CN202210361983.6，一种预防新型冠状病毒感染的中药组合物及其制备方法。该中药组合物包括以下组分：黄芪、黄芩片、北柴胡、防风、桑叶、芦根、板蓝根、桔梗、薄荷、连翘、白术、茯苓、甘草。该发明申请含本发明黄芪、防风、芦根、板蓝根、桔梗、连翘、白术、甘草等原料，但该发明申请以解表散寒、扶正祛邪、益气养阴、宣肺透邪为法，其说明书记载；“黄芪补气固表、托毒排脓、利尿生肌；防风祛风解表除湿，使邪有去路；北柴胡疏肝解郁、升举阳气；配白术健脾燥湿以加强北柴胡补气健脾之力；配以薄荷、连翘以清热解毒消肿，增强祛风解表之功效；佐使甘草片健脾和中、润肺解毒、调和诸药。具有扶正除疫，疏风润燥，清热解毒之功，可有效预防新型冠状病毒感染。”但从其立法原则上是祛邪为主，兼以扶正，君臣药味不清晰，佐使药仅甘草一味不妥。本发明以正虚为本，组方君药黄芪，补益肺气、益卫固表，防治毒邪侵入，臣药白术健脾益气；五味子益肾补气，共助君药补气益卫固表。佐药防风祛风解表，抵御外邪；金银花清热解毒；连翘清热解毒；板蓝根清热解毒、凉血利咽；鱼腥草清热解毒；芦根清热泻火，可清透肺热止咳；天花粉清热泻火，既能泻火以清肺热，又能生津以润肺燥，治燥热伤肺，干咳少痰、痰中带血等肺热燥咳证；桔梗宣肺、祛痰、利咽，保护上呼吸道，共助君药扶正祛邪。使药甘草补中益气，清热解毒，调和诸药。诸药合用，共凑益气固表、清热解毒、清肺利咽。(2)申请(专利)号：CN202110952216.8，一种中药组合物在制备抑制新冠病毒感染患者细胞因子和趋化因子升高的药物中的应用，其特征在于该中药组合由下列重量份的原料药制成：连翘、金银花、板蓝根、大黄、广藿香、绵马贯众、红景天、薄荷脑、炙麻黄、炒苦杏仁、鱼腥草、甘草、石膏。该发明申请含本发明连翘、金银花、板蓝根、鱼腥草、甘草等原料，但该发明申请说明书记载；以“清瘟解毒，宣肺泄热”为治法研制的创新中药组合物。全方以汉代张仲景《伤寒论》麻杏石甘汤合清代吴鞠通《温病条辨》银翘散为基础方，并汲取明代吴又可《温疫论》治疫证用大黄经验，配伍红景天清肺化瘀，调节免疫，组方体现了两千年来中医药防治此类疫病的用药经验，特别针对本次新型冠状病毒感染的发病机理和表现症状，进行处方的调整和制备方法的调整，临床适用于呼吸系统传染病伴发热、恶寒、咳嗽、肌肉酸痛等。该发明专利是以“清瘟解毒，宣肺泄热”立法，重在祛邪，兼以扶正，与本发明明显不同。本发明以正虚为本，组方君药黄芪，补益肺气、益卫固表，防治毒邪侵入，臣药白术健脾益气；五味子益肾补气，共助君药补气益卫固表。佐药防风祛风解表，抵御外邪；金银花清热解毒；连翘清热解毒；板蓝根清热解毒、凉血利咽；鱼腥草清热解毒；芦根清热泻火，可清透肺热止咳；天花粉清热泻火，既能泻火以清肺热，又能生津以润肺燥，治燥热伤肺，干咳少痰、痰中带血等肺热燥咳证；桔梗宣肺、祛痰、利咽，保护上呼吸道，共助君药扶正祛邪。使药甘草补中益气，清热解毒，调和诸药。诸药合用，共凑益气固表、清热解毒、清肺利咽。There are only 2 items containing more than 5 raw materials of the present invention. Compared with the present invention, the differences are: (1) Application (patent) number: CN202210361983.6, a Chinese medicine composition for preventing novel coronavirus infection and its preparation method. The Chinese medicine composition includes the following components: astragalus, scutellaria baicalensis slices, northern bupleurum, siler, mulberry leaf, reed root, isatis root, platycodon, mint, forsythia, atractylodes, tuckahoe, and liquorice. The invention application contains the raw materials of the present invention such as astragalus, siler, reed root, isatis root, platycodon, forsythia, atractylodes, and licorice, but the invention application is based on the method of dispelling cold, strengthening the body and eliminating evil, invigorating qi and nourishing yin, and promoting lung function and expelling evil. Its specification records; "Astragalus replenishes qi and consolidates the exterior, supports toxins and discharges pus, and has diuresis and muscle regeneration; siler dispels wind, relieves exterior symptoms and eliminates dampness, so that evil has a way out; Bupleurum chinense soothes the liver and relieves depression, and raises yang qi; it is matched with atractylodes to strengthen the spleen and dry dampness to strengthen the ability of Bupleurum chinense to replenish qi and strengthen the spleen; it is matched with mint and forsythia to clear away heat, detoxify and reduce swelling, and enhance the effect of dispelling wind and relieving exterior symptoms; the auxiliary licorice tablets strengthen the spleen and harmonize the middle, moisten the lungs and detoxify, and harmonize various medicines. It has the functions of strengthening the body and eliminating epidemics, dispelling wind and moistening dryness, clearing heat and detoxifying, and can effectively prevent new coronavirus infection." However, from the legislative principle, it is mainly to eliminate evil and strengthen the body at the same time. The taste of the monarch and ministerial medicines is not clear, and it is inappropriate to have only licorice as the auxiliary medicine. The present invention is based on deficiency of vital energy, and the main drug of the prescription, Astragalus membranaceus, can replenish lung qi, benefit the body and consolidate the exterior, prevent and treat the invasion of toxic evil, and the assistant drug Atractylodes macrocephala can strengthen the spleen and replenish qi; Schisandra chinensis can benefit the kidney and replenish qi, and help the main drug to replenish qi, benefit the body and consolidate the exterior. The auxiliary drug Saposhnikovia divaricata can dispel wind and relieve the exterior, and resist external evil; Honeysuckle can clear away heat and detoxify; Forsythia suspensa can clear away heat and detoxify; Isatis root can clear away heat and detoxify, cool blood and relieve throat; Houttuynia cordata can clear away heat and detoxify; Phragmites australis can clear away heat and purge fire, and can clear lung heat and relieve cough; Radix Trichosanthis can clear away heat and purge fire, and can purge fire to clear lung heat, and can also produce body fluid to moisten lung dryness, and treat dry heat and lung injury, dry cough with little sputum, blood in sputum and other lung heat and dry cough syndrome; Platycodon grandiflorum can clear the lung, remove sputum, relieve throat, protect the upper respiratory tract, and help the main drug to strengthen the body and eliminate evil. The assistant drug Licorice can replenish the middle and replenish qi, clear away heat and detoxify, and harmonize the drugs. The drugs are used together to replenish qi and consolidate the exterior, clear away heat and detoxify, and clear the lung and relieve throat. (2) Application (patent) number: CN202110952216.8, the use of a Chinese medicine composition in the preparation of a drug for inhibiting the increase of cytokines and chemokines in patients infected with the new coronavirus, characterized in that the Chinese medicine composition is made of the following raw materials in parts by weight: Forsythia suspensa, honeysuckle, isatis root, rhubarb, patchouli, cyperus rotundus, rhodiola rosea, menthol, roasted ephedra, stir-fried bitter almonds, houttuynia cordata, licorice, and gypsum. This invention application contains the raw materials of the present invention such as Forsythia suspensa, honeysuckle, isatis root, houttuynia cordata, and licorice, but the invention application description records: an innovative Chinese medicine composition developed with the treatment method of "clearing away plague and detoxifying, promoting lung function and relieving heat". The whole prescription is based on the Ma Xing Shi Gan Tang in the Treatise on Febrile Diseases by Zhang Zhongjing in the Han Dynasty and Yin Qiao San in the Treatise on Warm Diseases by Wu Jutong in the Qing Dynasty. It also draws on the experience of using rhubarb to treat epidemic symptoms in the Treatise on Warm Epidemics by Wu Youke in the Ming Dynasty, and is combined with Rhodiola rosea to clear the lungs and remove blood stasis, regulate immunity, and the prescription reflects the experience of Chinese medicine in preventing and treating such epidemic diseases for two thousand years. In particular, the prescription and preparation method are adjusted according to the pathogenesis and symptoms of the new coronavirus infection. It is clinically applicable to respiratory infectious diseases accompanied by fever, aversion to cold, cough, muscle aches, etc. This invention patent is legislated on "clearing plague and detoxifying, promoting lung function and venting heat", focusing on eliminating evil and strengthening the body, which is obviously different from the present invention. The present invention is based on deficiency of the body, and the main drug of the prescription is Astragalus membranaceus, which replenishes lung qi, benefits the body and consolidates the exterior, prevents and treats the invasion of toxic evil, and the minister drug Atractylodes macrocephala strengthens the spleen and replenishes qi; Schisandra chinensis benefits the kidney and replenishes qi, and helps the main drug replenish qi, benefits the body and consolidates the exterior. The adjuvant drug Saposhnikovia dispels wind and relieves the exterior symptoms, resisting external pathogens; Honeysuckle clears heat and detoxifies; Forsythia clears heat and detoxifies; Isatis root clears heat and detoxifies, cools blood and relieves sore throat; Houttuynia cordata clears heat and detoxifies; Phragmites australis clears heat and purges fire, can clear lung heat and relieve cough; Radix Trichosanthis clears heat and purges fire, can purge fire to clear lung heat, and can produce fluid to moisten lung dryness, treat dryness and heat damage to the lung, dry cough with little sputum, blood in sputum and other lung heat and dry cough symptoms; Platycodon grandiflorum clears the lungs, removes phlegm, relieves sore throat, protects the upper respiratory tract, and helps the monarch drug to strengthen the body and eliminate evil. The messenger drug Licorice replenishes the middle and replenishes qi, clears heat and detoxifies, and harmonizes the drugs. The drugs are used together to replenish qi, consolidate the exterior symptoms, clear heat and detoxify, clear the lungs and relieve sore throat.

三、发明内容III. Summary of the invention

本发明的目的在于提供一种扶正固本防治新冠的组合物及其制备方法，适用于免疫力低下、年老体弱或伴有其他疾病的机体抵抗力下降的易感人群预防外感病和或传染性疾病，以及新型冠状病毒感染人群。The purpose of the present invention is to provide a composition for strengthening the body and preventing and treating COVID-19 and a preparation method thereof, which is suitable for preventing exogenous diseases and/or infectious diseases in susceptible populations with low immunity, the elderly and frail, or those with reduced body resistance due to other diseases, as well as people infected with the new coronavirus.

本发明的技术方案：一种扶正固本防治新冠的组合物，由黄芪、白术、五味子、防风、金银花、连翘、板蓝根、鱼腥草、芦根、天花粉、桔梗、甘草制成，其特征在于是由下述原料成份和重量配比制备而成：黄芪3～27份、白术2～18份、五味子2～18份、防风2～18份、金银花2～18份、连翘2～18份、板蓝根2～18份、鱼腥草2～18份、芦根2～18份、天花粉2～18份、桔梗2～18份、甘草1～9份。本发明优选重量配比范围是：黄芪5～18份、白术3～12份、五味子3～12份、防风3～12份、金银花3～12份、连翘3～12份、板蓝根3～12份、鱼腥草3～12份、芦根3～12份、天花粉3～12份、桔梗3～12份、甘草2～6份。本发明最佳重量配比范围是：黄芪9份、白术6份、五味子6份、防风6份、金银花6份、连翘6份、板蓝根6份、鱼腥草6份、芦根6份、天花粉6份、桔梗6份、甘草3份。The technical solution of the present invention: A composition for strengthening the body and preventing and treating COVID-19, which is made of astragalus, atractylodes, schisandra, siler, honeysuckle, forsythia, isatis root, houttuynia, reed root, trichosanthes, platycodon, and licorice, and is characterized in that it is prepared from the following raw materials and weight ratios: 3-27 parts of astragalus, 2-18 parts of atractylodes, 2-18 parts of schisandra, 2-18 parts of siler, 2-18 parts of honeysuckle, 2-18 parts of forsythia, 2-18 parts of isatis root, 2-18 parts of houttuynia, 2-18 parts of reed root, 2-18 parts of trichosanthes, 2-18 parts of platycodon, and 1-9 parts of licorice. The preferred weight ratio range of the present invention is: 5-18 parts of Astragalus, 3-12 parts of Atractylodes, 3-12 parts of Schisandra, 3-12 parts of Saposhnikovia, 3-12 parts of Honeysuckle, 3-12 parts of Forsythia, 3-12 parts of Isatis, 3-12 parts of Houttuynia, 3-12 parts of Phragmites, 3-12 parts of Radix Trichosanthis, 3-12 parts of Platycodon, and 2-6 parts of Licorice. The best weight ratio range of the present invention is: 9 parts of Astragalus, 6 parts of Atractylodes, 6 parts of Schisandra, 6 parts of Saposhnikovia, 6 parts of Honeysuckle, 6 parts of Forsythia, 6 parts of Isatis, 6 parts of Houttuynia, 6 parts of Phragmites, 6 parts of Trichosanthes, 6 parts of Platycodon, and 3 parts of Licorice.

一种扶正固本防治新冠的组合物的制备方法，其特征在于采用药学上可接受的载体或赋形剂制成的任何剂型，如配方颗粒剂、颗粒剂、汤剂、片剂、胶囊剂、软胶囊剂、滴丸剂或丸剂。A method for preparing a composition for strengthening the body and preventing and treating COVID-19, characterized in that it uses any dosage form made of pharmaceutically acceptable carriers or excipients, such as formulated granules, granules, decoctions, tablets, capsules, soft capsules, pellets or pills.

一种扶正固本防治新冠的组合物的制备方法，其特征在于配方颗粒剂制备：按配方量分别称取组合物原料黄芪、白术、五味子、防风、金银花、连翘、板蓝根、鱼腥草、芦根、天花粉、桔梗、甘草，根据国家药品监督管理局颁布的中药配方颗粒国家药品标准分别换算成颗粒剂，混匀，包装，每袋10克。A method for preparing a composition for strengthening the body and preventing and treating COVID-19, which is characterized by the preparation of formula granules: weigh the raw materials of the composition, including astragalus, atractylodes, schisandra, siler, honeysuckle, forsythia, isatis root, houttuynia, reed root, radix trichosanthis, platycodon, and licorice, according to the formula amount, convert them into granules according to the national drug standards for Chinese medicine formula granules promulgated by the State Food and Drug Administration, mix them evenly, and package them, 10 grams per bag.

一种扶正固本防治新冠的组合物的制备方法，其特征在于汤剂按以下步骤制备：A method for preparing a composition for strengthening the body and preventing and treating COVID-19, characterized in that the decoction is prepared according to the following steps:

(1)称取原料：按配方量分别称取组合物原料黄芪、白术、五味子、防风、金银花、连翘、板蓝根、鱼腥草、芦根、天花粉、桔梗、甘草；(1) Weighing the raw materials: weigh the raw materials of the composition according to the formula amount, including astragalus, atractylodes, schisandra, siler, honeysuckle, forsythia, isatis root, houttuynia, phragmites, radix trichosanthis, platycodon, and liquorice;

(2)浸泡：将配方量原料投入中药煎煮专用容器，加6～8倍量冷水(符合国家卫生标准的饮用水)，浸泡30分钟，以备煎煮；(2) Soaking: Put the formulated amount of raw materials into a container dedicated for Chinese medicine decoction, add 6 to 8 times the amount of cold water (drinking water that meets national health standards), and soak for 30 minutes to prepare for decoction;

(3)第1次煎煮：将浸泡好的中药和水，用武火煎煮至沸腾后，转为文火煎煮10～20分钟，关火，药液趁热完全倒出过滤，即得药液200ml，储存于已消毒的容器，备用；(3) First decoction: Boil the soaked Chinese medicine and water over high heat until boiling, then simmer for 10 to 20 minutes over low heat, turn off the heat, pour out the liquid medicine while it is still hot and filter it to obtain 200 ml of liquid medicine, which is stored in a sterilized container for later use;

(4)第2次煎煮：将第1煎的药渣加入6～8倍量冷水(符合国家卫生标准的饮用水)，武火煎煮至沸腾后，转为文火继续煎煮10～20分钟，关火，药液趁热完全倒出过滤，并压榨药渣过滤，共取得药液200ml；(4) Second decoction: Add 6 to 8 times the amount of cold water (drinking water that meets national health standards) to the residue from the first decoction, boil over high heat until boiling, then switch to low heat and continue boiling for 10 to 20 minutes. Turn off the heat, pour out the liquid while it is still hot and filter it, and squeeze the residue to filter it, obtaining a total of 200 ml of liquid.

(5)混合：将第2煎药液倒入盛放第1煎药液容器内并混合均匀，即得药液，分包装，每袋200ml。(5) Mixing: Pour the second decoction into the container containing the first decoction and mix well to obtain the decoction. Then, package the decoction in 200 ml bags.

一种扶正固本防治新冠的组合物的制备方法，其特征在于颗粒剂制备辅料加入菊粉3～10份，三氯蔗糖0.04～0.16份，异麦芽酮糖醇加至总量(小试出膏率约20～25％)，按以下步骤制备：A method for preparing a composition for strengthening the body and preventing and treating COVID-19, characterized in that 3 to 10 parts of inulin, 0.04 to 0.16 parts of sucralose, and isomalt are added to the total amount (the small test paste yield is about 20 to 25%) as auxiliary materials for preparing granules, and the preparation is carried out according to the following steps:

(1)前处理：取异麦芽酮糖醇粉碎过80目筛，备用，其余物料若有结块，即可过80目筛；(1) Pretreatment: Grind isomalt and pass it through an 80-mesh sieve for later use. If the remaining materials are lumpy, pass them through an 80-mesh sieve;

(2)煎煮：按配料单称取黄芪、白术、五味子、防风、金银花、连翘、板蓝根、鱼腥草、芦根、天花粉、桔梗、甘草加10倍量水煎煮2次，第1次煎煮2小时，第2次煎煮1小时，过滤，备用；(2) Decoction: according to the ingredient list, weigh astragalus, atractylodes, schisandra, siler, honeysuckle, forsythia, isatis root, houttuynia, reed root, radix trichosanthis, platycodon, and liquorice, add 10 times the amount of water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, filter, and set aside;

(3)浓缩：滤液减压减压浓缩(-0.06～-0.10MPa，≤70℃)至相对密度为1.15～1.25(60±2℃)的稠膏；(3) Concentration: The filtrate is concentrated under reduced pressure (-0.06 to -0.10 MPa, ≤70°C) to a thick paste with a relative density of 1.15 to 1.25 (60±2°C);

(4)干燥：稠膏减压干燥(-0.06～-0.10Mpa，≤70℃)至干，粉碎过80目筛，得干浸膏粉，备用；(4) Drying: Dry the thick paste under reduced pressure (-0.06 to -0.10 MPa, ≤70°C) until dry, grind through an 80-mesh sieve to obtain dry extract powder for later use;

(5)制粒：按配方量称取异麦芽酮糖醇、菊粉和干浸膏粉一起置高效湿法制粒机中混合5分钟，得混合粉；将三氯蔗糖溶于95％乙醇(约占处方总量18％，乙醇浓度及用量可根据实际情况进行调整)作为润湿剂制软材，14目制粒，55±5℃温度下干燥(颗粒含水量控制在5％以下)，14目整粒，得干颗粒，备用；(5) Granulation: isomalt, inulin and dry extract powder are weighed according to the formula amount, placed in a high-efficiency wet granulator and mixed for 5 minutes to obtain a mixed powder; sucralose is dissolved in 95% ethanol (accounting for about 18% of the total formula, and the ethanol concentration and amount can be adjusted according to actual conditions) as a wetting agent to prepare a soft material, granulated with 14 mesh, dried at 55±5°C (the moisture content of the granules is controlled to be below 5%), and granulated with 14 mesh to obtain dry granules for later use;

(6)内包装：复合膜包装，10g/袋；(6) Inner packaging: composite film packaging, 10g/bag;

(7)外包装：贴标签，装盒，装箱，待检验合格后入库；(7) Outer packaging: labeling, boxing, and packaging, and storage after passing inspection;

(8)检验入库：成品经检验合格后，入库。(8) Inspection and warehousing: Finished products are put into storage after passing the inspection.

本发明技术原创性在于针对外感病和或传染性疾病发病为正气亏虚的基本病机，将正虚与免疫相结合，组方君药黄芪，补益肺气、益卫固表，防治毒邪侵入。臣药白术健脾益气；五味子益肾补气，共助君药补气益卫固表。佐药防风祛风解表，抵御外邪；金银花清热解毒；连翘清热解毒；板蓝根清热解毒、凉血利咽；鱼腥草清热解毒；芦根清热泻火，可清透肺热止咳；天花粉清热泻火，既能泻火以清肺热，又能生津以润肺燥，治燥热伤肺，干咳少痰、痰中带血等肺热燥咳证；桔梗宣肺、祛痰、利咽，保护上呼吸道，共助君药扶正祛邪。使药甘草补中益气，清热解毒，调和诸药。诸药合用，共凑益气固表、清热解毒、清肺利咽。The originality of the technology of the present invention lies in targeting the basic pathogenesis of exogenous diseases and/or infectious diseases as deficiency of vital energy, combining vital energy deficiency with immunity, formulating the main drug Huangqi, replenishing lung qi, strengthening the body's defense and exterior, and preventing and treating the invasion of toxic evil. The assistant drug Baizhu strengthens the spleen and replenishes qi; Schisandra chinensis replenishes the kidney and replenishes qi, and helps the main drug to replenish qi, strengthen the body's defense and exterior. The adjuvant drug Fangfeng dispels wind and relieves exterior symptoms, and resists exogenous evil; Honeysuckle clears heat and detoxifies; Forsythia clears heat and detoxifies; Isatis root clears heat and detoxifies, cools blood and relieves throat; Houttuynia cordata clears heat and detoxifies; Phragmites australis clears heat and purges fire, and can clear lung heat and relieve cough; Radix Trichosanthis clears heat and purges fire, and can purge fire to clear lung heat, and can also produce fluid to moisten lung dryness, and treat dryness and heat damage to the lung, dry cough with little sputum, blood in sputum and other lung heat and dry cough syndromes; Platycodon grandiflorum clears the lung, removes phlegm, relieves throat, protects the upper respiratory tract, and helps the main drug to strengthen the body and eliminate evil. The assistant drug Licorice replenishes the middle and replenishes qi, clears heat and detoxifies, and harmonizes the various drugs. The combination of these medicines can replenish Qi, strengthen the exterior, clear away heat and detoxify, clear the lungs and relieve sore throat.

本发明配方颗粒剂治疗新冠感染患者32例临床观察。Clinical observation on 32 patients infected with COVID-19 treated with the granules of the present invention.

1、一般资料：32例患者来源于2022年11月1日～12月10日隔离区患者，男24例，女18例。年龄18～59岁，病程1-2天。1. General information: 32 patients were from patients in the quarantine area from November 1 to December 10, 2022, including 24 males and 18 females. Aged 18 to 59 years, with a course of 1-2 days.

2、诊断标准：参照新型冠状病毒感染诊疗方案(试行第九版)2. Diagnostic criteria: Refer to the Diagnosis and Treatment Plan for Novel Coronavirus Infection (Trial Version 9)

3、纳入标准：(1)患者出现发热、咽痛、周身酸痛、睡眠困难等症状；(2)核酸检测阳性或兼(3)新冠抗原检测阳性。3. Inclusion criteria: (1) Patients have symptoms such as fever, sore throat, body aches, and difficulty sleeping; (2) Nucleic acid test is positive or (3) COVID-19 antigen test is positive.

4、试验方法4. Test methods

(1)本发明配方颗粒剂(由黄芪、白术、五味子、防风、金银花、连翘、板蓝根、鱼腥草、芦根、天花粉、桔梗、甘草制成，由康仁堂药业制备，每袋10克)(1) Granules of the present invention (made from astragalus, atractylodes, schisandra, siler, honeysuckle, forsythia, isatis root, houttuynia, reed root, radix trichosanthis, platycodon grandiflorum, and liquorice, prepared by Kangrentang Pharmaceutical Co., Ltd., 10 g per bag)

(2)使用方法：第一天：首次服用2袋，2小时后再服2袋，在第2次服后3小时再服2袋，在第3次服后4小时再服2袋；第二天：一次1袋，一天2-3次；第三天：一次1袋，一天2次。(2) Usage: Day 1: Take 2 bags for the first time, then take 2 bags 2 hours later, then take 2 bags 3 hours after the second dose, then take 2 bags 4 hours after the third dose; Day 2: Take 1 bag at a time, 2-3 times a day; Day 3: Take 1 bag at a time, 2 times a day.

5、观察指标：(1)体温、咽痛、周身酸痛、睡眠困难；(2)核酸检测；(3)新冠抗原检测。5. Observation indicators: (1) body temperature, sore throat, body aches, and difficulty sleeping; (2) nucleic acid testing; (3) new coronavirus antigen testing.

6、试验结果6. Test results

(1)患者体温、咽痛、睡眠困难、周身酸痛变化情况(1) Changes in the patient's body temperature, sore throat, difficulty sleeping, and body aches

表1患者体温、咽痛、睡眠困难、周身酸痛改善时间Table 1 Improvement time of patients' body temperature, sore throat, difficulty sleeping and body aches

由表1可见经本发明配方颗粒剂治疗后，患者体温、咽痛、周身酸痛、睡眠困难大部分在6-8小时改善，一般在20小时内症状就可以基本消失。As shown in Table 1, after treatment with the granules of the present invention, the patient's body temperature, sore throat, body aches, and sleep difficulties are mostly improved within 6-8 hours, and generally the symptoms can be basically eliminated within 20 hours.

(2)核酸和抗原检测(2) Nucleic acid and antigen testing

因隔离区管理规定对确诊患者不再复查核酸和抗原，并且由于最近政策变化，对核酸和抗原检测执行改变，故没有治疗后系统检测数据。后对症状消失解除隔离的部分患者随访，部分患者5天后抗原复查阴性，核酸7天后阴性。Due to the quarantine area management regulations, confirmed patients will no longer be retested for nucleic acid and antigen, and due to recent policy changes, the implementation of nucleic acid and antigen testing has changed, so there is no systematic testing data after treatment. Later, some patients who were released from isolation after their symptoms disappeared were followed up, and some patients tested negative for antigen after 5 days and negative for nucleic acid after 7 days.

7、结论7. Conclusion

经本发明配方颗粒剂治疗后，患者体温、咽痛、周身酸痛、睡眠困难大部分在6-8小时改善，一般在20小时内症状就可以基本消失。表明本发明配方颗粒剂对新冠患者疗效确切。After treatment with the granules of the present invention, the patient's body temperature, sore throat, body aches, and sleep difficulties were mostly improved within 6-8 hours, and generally the symptoms disappeared within 20 hours. This shows that the granules of the present invention have a definite effect on COVID-19 patients.

四、具体实施方式4. Specific implementation methods

下面以具体实施例对本发明作详细说明：The present invention is described in detail below with specific embodiments:

实施例1：配方颗粒剂Example 1: Formula granules

按照下列配比称取原料：黄芪3份、白术2份、五味子2份、防风2份、金银花2份、连翘2份、板蓝根2份、鱼腥草2份、芦根2份、天花粉2份、桔梗2份、甘草1份。Weigh the raw materials according to the following ratio: 3 parts of Astragalus, 2 parts of Atractylodes, 2 parts of Schisandra, 2 parts of Saposhnikovia, 2 parts of Honeysuckle, 2 parts of Forsythia, 2 parts of Isatis, 2 parts of Houttuynia, 2 parts of Phragmites australis, 2 parts of Radix Trichosanthis, 2 parts of Platycodon, and 1 part of Licorice.

制备方法：根据国家药品监督管理局颁布的中药配方颗粒国家药品标准分别换算成颗粒剂，混匀，包装，每袋10克。Preparation method: According to the national drug standards for Chinese herbal formula granules promulgated by the State Food and Drug Administration, convert them into granules, mix them evenly, and package them, 10 grams per bag.

实施例2：配方颗粒剂Example 2: Formula granules

按照下列配比称取原料：黄芪27份、白术18份、五味子18份、防风18份、金银花18份、连翘18份、板蓝根18份、鱼腥草18份、芦根18份、天花粉18份、桔梗18份、甘草9份。Weigh the raw materials according to the following ratio: 27 parts of Astragalus, 18 parts of Atractylodes, 18 parts of Schisandra, 18 parts of Saposhnikovia, 18 parts of Honeysuckle, 18 parts of Forsythia, 18 parts of Isatis, 18 parts of Houttuynia, 18 parts of Phragmites australis, 18 parts of Radix Trichosanthis, 18 parts of Platycodon, and 9 parts of Licorice.

制备方法：根据国家药品监督管理局颁布的中药配方颗粒国家药品标准分别换算成颗粒剂，混匀，包装，每袋10克。Preparation method: According to the national drug standards for Chinese herbal formula granules promulgated by the State Food and Drug Administration, convert them into granules, mix them evenly, and package them, 10 grams per bag.

实施例3：配方颗粒剂Example 3: Formula granules

按照下列配比称取原料：黄芪9份、白术6份、五味子6份、防风6份、金银花6份、连翘6份、板蓝根6份、鱼腥草6份、芦根6份、天花粉6份、桔梗6份、甘草3份。Weigh the raw materials according to the following ratio: 9 parts of Astragalus, 6 parts of Atractylodes, 6 parts of Schisandra, 6 parts of Saposhnikovia, 6 parts of Honeysuckle, 6 parts of Forsythia, 6 parts of Isatis, 6 parts of Houttuynia, 6 parts of Phragmites australis, 6 parts of Radix Trichosanthis, 6 parts of Platycodon, and 3 parts of Licorice.

制备方法：根据国家药品监督管理局颁布的中药配方颗粒国家药品标准分别换算成颗粒剂，混匀，包装，每袋10克。Preparation method: According to the national drug standards for Chinese herbal formula granules promulgated by the State Food and Drug Administration, convert them into granules, mix them evenly, and package them, 10 grams per bag.

实施例4：汤剂Example 4: Decoction

按照下列配比称取原料：黄芪9份、白术6份、五味子6份、防风6份、金银花6份、连翘6份、板蓝根6份、鱼腥草6份、芦根6份、天花粉6份、桔梗6份、甘草3份。Weigh the raw materials according to the following ratio: 9 parts of Astragalus, 6 parts of Atractylodes, 6 parts of Schisandra, 6 parts of Saposhnikovia, 6 parts of Honeysuckle, 6 parts of Forsythia, 6 parts of Isatis, 6 parts of Houttuynia, 6 parts of Phragmites australis, 6 parts of Radix Trichosanthis, 6 parts of Platycodon, and 3 parts of Licorice.

制备方法：(1)称取原料：按配方量分别称取组合物原料黄芪、白术、五味子、防风、金银花、连翘、板蓝根、鱼腥草、芦根、天花粉、桔梗、甘草；(2)浸泡：将配方量原料投入中药煎煮专用容器，加6～8倍量冷水(符合国家卫生标准的饮用水)，浸泡30分钟，以备煎煮；(3)第1次煎煮：将浸泡好的中药和水，用武火煎煮至沸腾后，转为文火煎煮10～20分钟，关火，药液趁热完全倒出过滤，即得药液200ml，储存于已消毒的容器，备用；(4)第2次煎煮：将第1煎的药渣加入6～8倍量冷水(符合国家卫生标准的饮用水)，武火煎煮至沸腾后，转为文火继续煎煮10～20分钟，关火，药液趁热完全倒出过滤，并压榨药渣过滤，共取得药液200ml；(5)混合：将第2煎药液倒入盛放第1煎药液容器内并混合均匀，即得药液，分2袋包装，每袋200m1。Preparation method: (1) Weighing raw materials: weighing raw materials of the composition according to the formula amount, including astragalus, atractylodes, schisandra, siler, honeysuckle, forsythia, isatis root, houttuynia, reed root, radix trichosanthis, platycodon grandiflorum, and liquorice; (2) Soaking: putting the formula amount of raw materials into a container specially used for Chinese medicine decoction, adding 6 to 8 times the amount of cold water (drinking water that meets national health standards), and soaking for 30 minutes to prepare for decoction; (3) First decoction: boil the soaked Chinese medicine and water over high heat until boiling, then switch to low heat and boil for 10 to 20 minutes, turn off the heat, and let the medicine liquid finish while hot. Pour out and filter to obtain 200 ml of liquid medicine, which is then stored in a sterilized container for later use. (4) Second decoction: Add 6 to 8 times the amount of cold water (drinking water that meets national health standards) to the residue of the first decoction, boil over high heat until boiling, then switch to low heat and continue boiling for 10 to 20 minutes. Turn off the heat, pour out and filter the liquid medicine while it is still hot, and squeeze the residue to filter, to obtain a total of 200 ml of liquid medicine. (5) Mixing: Pour the second decoction into the container containing the first decoction and mix evenly to obtain the liquid medicine, which is packaged in 2 bags, each bag containing 200 ml.

实施例5：颗粒剂Example 5: Granules

按照下列配比称取原料和辅料：黄芪9份、白术6份、五味子6份、防风6份、金银花6份、连翘6份、板蓝根6份、鱼腥草6份、芦根6份、天花粉6份、桔梗6份、甘草3份；菊粉3～10份，三氯蔗糖0.04～0.16份，异麦芽酮糖醇加至总量(小试出膏率约20～25％)。Weigh the raw materials and auxiliary materials according to the following proportions: 9 parts of Astragalus, 6 parts of Atractylodes, 6 parts of Schisandra, 6 parts of Saposhnikovia, 6 parts of Honeysuckle, 6 parts of Forsythia, 6 parts of Isatis, 6 parts of Houttuynia, 6 parts of Phragmites, 6 parts of Radix Trichosanthis, 6 parts of Platycodon, 3 parts of Licorice; 3-10 parts of inulin, 0.04-0.16 parts of sucralose, and add isomalt to the total amount (the yield of the paste in a small test is about 20-25%).

制备方法：(1)前处理：取异麦芽酮糖醇粉碎过80目筛，备用，其余物料若有结块，即可过80目筛；(2)煎煮：按配料单称取黄芪、白术、五味子、防风、金银花、连翘、板蓝根、鱼腥草、芦根、天花粉、桔梗、甘草加10倍量水煎煮2次，第1次煎煮2小时，第2次煎煮1小时，过滤，备用；(3)浓缩：滤液减压减压浓缩(-0.06～-0.10MPa，≤70℃)至相对密度为1.15～1.25(60±2℃)的稠膏；(4)干燥：稠膏减压干燥(-0.06～-0.10Mpa，≤70℃)至于，粉碎过80目筛，得干浸膏粉，备用；(5)制粒：按配方量称取异麦芽酮糖醇、菊粉和干浸膏粉一起置高效湿法制粒机中混合5分钟，得混合粉；将三氯蔗糖溶于95％乙醇(约占处方总量18％，乙醇浓度及用量可根据实际情况进行调整)作为润湿剂制软材，14目制粒，55±5℃温度下干燥(颗粒含水量控制在5％以下)，14目整粒，得干颗粒，备用；(6)内包装：复合膜包装，10g/袋；(7)外包装：贴标签，装盒，装箱，待检验合格后入库；(8)检验入库：成品经检验合格后，入库。Preparation method: (1) Pretreatment: grind isomalt and pass through an 80-mesh sieve for later use. If the remaining materials are lumpy, pass through an 80-mesh sieve; (2) Decoction: weigh astragalus, atractylodes, schisandra, saposhnikovia, honeysuckle, forsythia, isatis root, houttuynia, reed root, radix trichosanthis, platycodon grandiflorum, and liquorice according to the ingredient list, add 10 times the amount of water and decoct twice, the first decoction is for 2 hours, the second decoction is for 1 hour, filter, and set aside; (3) Concentration: decompress the filtrate under reduced pressure (-0.06 to -0.10 MPa, ≤70°C) to a thick paste with a relative density of 1.15 to 1.25 (60±2°C); (4) Drying: decompress the thick paste under reduced pressure (-0.06 to -0.10 MPa, ≤70°C) As for, crush through 80 mesh sieve to obtain dry extract powder, set aside; (5) granulation: weigh isomalt, inulin and dry extract powder according to the formula amount, put them together in a high-efficiency wet granulator and mix for 5 minutes to obtain mixed powder; dissolve sucralose in 95% ethanol (about 18% of the total prescription, ethanol concentration and dosage can be adjusted according to actual conditions) as a wetting agent to prepare soft material, 14 mesh granulation, dry at 55±5℃ (the moisture content of the granules is controlled below 5%), 14 mesh granulation, obtain dry granules, set aside; (6) inner packaging: composite film packaging, 10g/bag; (7) outer packaging: labeling, boxing, packing, and storage after passing inspection; (8) inspection and storage: the finished product is stored after passing the inspection.

Claims (8)

1. The composition for strengthening body resistance and preventing and curing the new crown is characterized by being prepared from the following raw materials in parts by weight: 3-27 parts of astragalus, 2-18 parts of bighead atractylodes rhizome, 2-18 parts of shizandra berry, 2-18 parts of divaricate saposhnikovia root, 2-18 parts of honeysuckle, 2-18 parts of weeping forsythiae capsule, 2-18 parts of radix isatidis, 2-18 parts of cordate houttuynia, 2-18 parts of reed rhizome, 2-18 parts of radix trichosanthis, 2-18 parts of platycodon root and 1-9 parts of liquorice.
2. The composition for strengthening body resistance and preventing and curing new crown as claimed in claim 1, wherein the composition comprises the following raw materials in parts by weight: 5-18 parts of astragalus, 3-12 parts of bighead atractylodes rhizome, 3-12 parts of shizandra berry, 3-12 parts of divaricate saposhnikovia root, 3-12 parts of honeysuckle, 3-12 parts of weeping forsythiae capsule, 3-12 parts of radix isatidis, 3-12 parts of cordate houttuynia, 3-12 parts of reed rhizome, 3-12 parts of radix trichosanthis, 3-12 parts of platycodon root and 2-6 parts of liquorice.
3. The composition for strengthening body resistance and preventing and curing new crown as claimed in any one of claims 1-2, wherein the composition comprises the following raw materials in parts by weight: 9 parts of astragalus, 6 parts of bighead atractylodes rhizome, 6 parts of shizandra berry, 6 parts of divaricate saposhnikovia root, 6 parts of honeysuckle, 6 parts of weeping forsythiae capsule, 6 parts of radix isatidis, 6 parts of heartleaf houttuynia herb, 6 parts of reed rhizome, 6 parts of radix trichosanthis, 6 parts of platycodon root and 3 parts of liquorice.
4. A method for preparing a composition for strengthening body resistance and preventing and treating new crown as claimed in any one of claims 1 to 3, wherein any dosage form such as formulated granules, decoction, tablets, capsules, soft capsules, dripping pills or pills is prepared by adopting pharmaceutically acceptable carriers or excipients.
5. The method for preparing the composition for strengthening body resistance and preventing and curing the new crown as claimed in claim 4, wherein the formulation granules are prepared by weighing the composition raw materials of astragalus, bighead atractylodes rhizome, schisandra chinensis, radix sileris, honeysuckle, fructus forsythiae, radix isatidis, cordate houttuynia, reed rhizome, radix trichosanthis, platycodon grandiflorum and liquorice according to the formulation amount of the formulation, and respectively converting the formulation into granules according to the national drug standards of the traditional Chinese medicine formulation granules issued by the national drug administration, mixing uniformly, and packaging, wherein each bag is 10 g.
6. The preparation method of the composition for strengthening body resistance and preventing and treating new crown as recited in claim 4, wherein the decoction is prepared by the following steps: (1) weighing raw materials: the raw materials of astragalus, bighead atractylodes rhizome, schisandra chinensis, radix saposhnikoviae, honeysuckle, fructus forsythiae, radix isatidis, cordate houttuynia, reed rhizome, radix trichosanthis, platycodon grandiflorum and liquorice are respectively weighed according to the formula weight; (2) soaking: adding the raw materials of the formula into a special container for decocting the traditional Chinese medicines, adding 6-8 times of water and cold water, and soaking for 30 minutes to prepare for decoction; (3) 1 st decoction: decocting the soaked prescription medicine and water with strong fire until boiling, then decocting with slow fire for 10-20 minutes, turning off the fire, completely pouring out and filtering the hot liquid medicine to obtain 200ml of liquid medicine, and storing the liquid medicine in a sterilized container for later use; (4) 2 nd decoction: adding 6-8 times of cold water into the decoction dregs of the decoction of the 1 st step, decocting with strong fire until the decoction dregs are boiled, then continuously decocting with slow fire for 10-20 minutes, turning off the fire, completely pouring out and filtering the liquid medicine when the liquid medicine is hot, and squeezing the decoction dregs for filtering to obtain 200ml of liquid medicine; (5) mixing: pouring the 2 nd decoction into a1 st decoction container, mixing uniformly to obtain the decoction, and bagging each 200ml.
7. The method for preparing the composition for strengthening body resistance and preventing and curing the new crown as claimed in claim 4, wherein 3-10 parts of inulin and 0.04-0.16 part of sucralose are added to the auxiliary materials for preparing the granules, and isomalt is added to the total amount, and the composition is prepared according to the following steps: (1) pretreatment: crushing isomaltulose alcohol, sieving with an 80-mesh sieve for standby, and sieving with the 80-mesh sieve if other materials have caking; (2) decoction: weighing radix astragali, atractylodis rhizoma, fructus Schisandrae chinensis, radix Saposhnikoviae, flos Lonicerae, fructus forsythiae, radix Isatidis, herba Houttuyniae, rhizoma Phragmitis, radix Trichosanthis, radix Platycodi and Glycyrrhrizae radix according to the formula, decocting with 10 times of water for 2 times, 1 st time for 2 hours, 2 nd time for 1 hour, and filtering; (3) concentrating: concentrating the filtrate under reduced pressure of-0.06 to-0.10 MPa at a temperature of less than or equal to 70 ℃ to obtain thick paste with a relative density of 1.15-1.25 at 60+/-2 ℃; (4) drying: drying the thick paste under reduced pressure of-0.06 to-0.10 Mpa at a temperature of less than or equal to 70 ℃ until the thick paste is dried, crushing the thick paste, and sieving the crushed thick paste with a 80-mesh sieve to obtain dry extract powder for later use; (5) granulating: weighing isomaltulose alcohol, inulin and dry extract powder according to the formula amount, and mixing in a high-efficiency wet granulator for 5 minutes to obtain mixed powder; dissolving sucralose in 95% ethanol as wetting agent to obtain soft material, granulating with 14 meshes, drying at 55+ -5deg.C, controlling water content of granule below 5%, and grading with 14 meshes to obtain dry granule; (6) inner packaging: packaging with a composite film, wherein the weight of the composite film is 10 g/bag; (7) external packing: labeling, boxing and boxing, and warehousing after the inspection is qualified; and (8) checking and warehousing: and (5) after the finished product is qualified by inspection, warehousing.
8. Use of a composition according to any one of claims 1 to 3 for the preparation of a medicament for the prevention of an exogenous disease and/or an infectious disease in a susceptible population suffering from reduced immunity, aged or infirm or a reduced body resistance associated with other diseases, and a novel coronavirus infection.
CN202211592842.1A 2022-12-12 2022-12-12 A composition for strengthening the body and preventing and treating COVID-19 and a preparation method thereof Pending CN118384239A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104840786A (en) * 2015-05-14 2015-08-19 北京康华远景科技股份有限公司 Medicine combination for preventing bird flu and preparation method thereof
CN111214577A (en) * 2020-03-02 2020-06-02 上海知萌生物医药科技有限公司 Natural antiviral plant extract compound temperature-sensitive gel spray and preparation method thereof
CN111249390A (en) * 2020-03-12 2020-06-09 尧舜泽生物医药(南京)有限公司 A kind of Qiaoqi compound preparation and its preparation method and use
CN111643562A (en) * 2020-06-09 2020-09-11 杨洪彬 Traditional Chinese medicine composition for preventing new coronary pneumonia and preparation method and application thereof
CN111956722A (en) * 2020-09-10 2020-11-20 江苏医药职业学院 Antiviral traditional Chinese medicine composition
CN113577140A (en) * 2021-07-28 2021-11-02 黑龙江中医药大学附属第一医院（黑龙江中医药大学第一临床医学院） Traditional Chinese medicine composition for treating neocoronary pneumonia and preparation method and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101972338B (en) * 2010-10-14 2012-01-11 尚德信 Chinese medicinal preparation for treating infantile upper respiratory tract infection and preparation method thereof
CN111437355B (en) * 2020-04-20 2021-08-03 北京中一堂医疗科技有限公司 Traditional Chinese medicine composition and preparation method and application thereof
CN111544556A (en) * 2020-05-07 2020-08-18 中国人民解放军军事科学院军事医学研究院 A Chinese medicinal composition for treating viral common cold and viral pneumonia, and its administration method and preparation method
CN113456771A (en) * 2021-08-26 2021-10-01 江柏华 Traditional Chinese medicine composition for treating influenza and Yinlian antipyretic and detoxifying oral liquid containing traditional Chinese medicine composition

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104840786A (en) * 2015-05-14 2015-08-19 北京康华远景科技股份有限公司 Medicine combination for preventing bird flu and preparation method thereof
CN111214577A (en) * 2020-03-02 2020-06-02 上海知萌生物医药科技有限公司 Natural antiviral plant extract compound temperature-sensitive gel spray and preparation method thereof
CN111249390A (en) * 2020-03-12 2020-06-09 尧舜泽生物医药(南京)有限公司 A kind of Qiaoqi compound preparation and its preparation method and use
CN111643562A (en) * 2020-06-09 2020-09-11 杨洪彬 Traditional Chinese medicine composition for preventing new coronary pneumonia and preparation method and application thereof
CN111956722A (en) * 2020-09-10 2020-11-20 江苏医药职业学院 Antiviral traditional Chinese medicine composition
CN113577140A (en) * 2021-07-28 2021-11-02 黑龙江中医药大学附属第一医院（黑龙江中医药大学第一临床医学院） Traditional Chinese medicine composition for treating neocoronary pneumonia and preparation method and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
宋成等: "基于中医‘治未病’理论筛选预防新型冠状病毒肺炎的‘药食同源’类中药", 《亚太传统医药》, vol. 16, no. 11, 30 November 2020 (2020-11-30), pages 18 - 21 *

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