CN1179727A - Biological tissue stimulation by optical energy - Google Patents

Biological tissue stimulation by optical energy Download PDF

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Publication number
CN1179727A
CN1179727A CN95197798A CN95197798A CN1179727A CN 1179727 A CN1179727 A CN 1179727A CN 95197798 A CN95197798 A CN 95197798A CN 95197798 A CN95197798 A CN 95197798A CN 1179727 A CN1179727 A CN 1179727A
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laser
scope
tissue
low level
time
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G·J·比林格
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LASER BIOTHERAPY CO
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LASER BIOTHERAPY CO
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M1/00—Stationary means for catching or killing insects
    • A01M1/02—Stationary means for catching or killing insects with devices or substances, e.g. food, pheronones attracting the insects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M1/00—Stationary means for catching or killing insects
    • A01M1/02—Stationary means for catching or killing insects with devices or substances, e.g. food, pheronones attracting the insects
    • A01M1/04—Attracting insects by using illumination or colours
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M1/00—Stationary means for catching or killing insects
    • A01M1/10—Catching insects by using Traps
    • A01M1/106—Catching insects by using Traps for flying insects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M2200/00—Kind of animal
    • A01M2200/01—Insects
    • A01M2200/012—Flying insects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00137—Details of operation mode
    • A61B2017/00141—Details of operation mode continuous, e.g. wave
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00137—Details of operation mode
    • A61B2017/00154—Details of operation mode pulsed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals

Abstract

The method of using a low level reactive laser system from 100 milliwatts to 800 milliwatts in either a pulsed or continuous mode with optical energy produced by a Nd: YAG laser at a fundamental wavelength of 1064 nanometers has been found to reduce pain in soft tissues, reduce inflammation and enhance the healing of tissue by stimulation of microcirculation without subjecting the living tissue to damaging thermal effects.

Description

Method with the luminous energy biological tissue stimulation
Background of the present invention
1. invention field
Present invention relates in general to the method through light radiation treatment living organism tissue, specifically, the present invention relates to stimulates soft living tissue method with laser emission.
2. background technology is described
Various non-operative treatments have been used for living tissue treatment to be handled.This technology comprises the high frequency stimulation that uses ultrasonic wave energy, electricity irritation, carries out with diathermy, X ray and microwave irradiation.The technology of electricity irritation, diathermy, X-ray and microwave irradiation and so on has demonstrated some treatment advantage to soft tissue.Yet because the tissue injury that over-drastic heat effect causes, their use is subjected to restriction to a certain degree.Thereby with relating to diathermy, X ray, the treatment of microwave and electricity irritation is handled relevant energy level and has been limited on the so low level so that can only obtain benefit seldom or can not obtain benefit at all.In addition, must careful ground controlled microwave and the dosage of x-ray radiation or be exposed to avoid occurring the health problem relevant with described radiation.Ultrasonic wave energy is not by preferential absorption and influence all tissues on every side.
The luminous energy that is produced by laser has been applied to various medical science and surgery purpose, because the monochrome and the successive character of laser beam, some feature (comprising reflectance, absorptance, scattering coefficient, pyroconductivity and thermal-diffusion constant) of the character of the tissue that foundation is shone and the wavelength of light, it can optionally be absorbed by living tissue.Reflectance, absorptance and scattering coefficient depend on the wavelength of light radiation.The known absorbing coefficient depends on the factor (it depends on the wavelength of light radiation) of (interband) transition in the band, free electron absorption, grid absorption (phonon absorption) and impurity absorption and so on.
In living tissue, water is a main component that absorption band (according to the vibration of hydrone) arranged in infra-red range.Because the existence of hemoglobin exists to absorb in visible range.And the scattering coefficient in living tissue is a factor in the highest flight.
Like this, for a kind of given types of organization, laser beam can be by organizational communication, and is unattenuated basically, perhaps almost can be absorbed up hill and dale.Tissue is heated and final ruined degree depends on that it absorbs the degree of luminous energy.In general, laser beam preferably is transmitted in the impregnable tissue of hope basically, is absorbed in treating affected tissue.For example,, wish luminous energy, thereby make the laser can be specifically at tissue to be treated not by water or blood absorption when when using laser emission by the tissue place of blood or water-wet.Another advantage of laser therapy be luminous energy can be with accurately, very limited position and be sent to treated tissue with predetermined limited energy level.
The luminous energy of known ruby and argon laser emission electromagnetic spectrum visible part, and be successfully used to the ophthalmology field, so that retina is connected on the following choroid, and pressure is treated glaucoma between the part of the eyes front that wore long minimizing eye.Ruby laser can have the wavelength of 694 nanometers, in the red part of visible spectrum.Argon laser is transmitted in the energy of 488 and 515 nanometers, therefore appears at the aeruginous part of visible spectrum.Ruby and argon laser light beam are absorbed by water rarely, but by blood chromogen hemoglobin strong absorption.Like this, ruby and argon laser can seldom be absorbed by the tissue of non-staining (as cornea, lens and vitreous body), but the retinal absorption that is colored preferably, and heat effect takes place at this in then.
The another kind of type of laser that has adopted in surgical operation is carbon dioxide (CO 2) gas laser, the light beam that its emission is absorbed by water consumingly.CO 2Therefore Wavelength of Laser is 10.6 microns, is positioned at the invisible far-infrared band of electromagnetic spectrum, and does not rely on tissue color and had the soft tissue absorbed of high water content by all.Like this, CO 2Laser has constituted a good surgical scalpels and carburator.Because it is absorbed fully, so its depth as shallow that penetrates can be accurately controlled with regard to the tissue surface of being treated.Therefore, CO 2Laser is suitable in the various surgical methods very much, and wherein it is essential to the evaporation or the colourless tissue that condenses, the heat damage of the minimum that adjacent tissue is had.
Another laser that is extensively utilized is Yttrium-Aluminium-Garnet (Nd:YAG) laser of neodymium coating.Nd:YAG laser its 1,320 nanometer, second wavelength place in the near infrared region of electromagnetic spectrum has the good way of effect.The Nd:YAG light emission is higher than the degree that is absorbed by water by the degree of blood absorption, and this makes it useful on the big hemorrhage vascular that condenses.Launched by endoscope at the Nd:YAG of 1,320 nanometer laser and to have treated the damage of bleeding of various gastrointestinals, as varices, ulcer of digestive system and the arteriovenous abnormalities of esophagus.Such laser can application needing to be very suitable for the occasion (as tissue vaporization, tissue ablation, condense) of high energy heat effect and as surgical knife.
Following U.S. Patent Publication handle living tissue instrument and method by laser emission treatment:
3,456,651?????3,720,213?????4,141,362
4,144,888????4,367,729???????4,561,440
4,573,465????4,589,404???????4,601,288
4,604,992????4,672,969???????4,692,924
4,705,036????4,931,053???????4,966,144
Three patent: Dew, 4,672,969.00; L Esperance, Jr.4,931,053.00 (applications on June 5 nineteen ninety); Prior art has fully been described in 4,966,144.00 (applications on October 30 nineteen ninety) with Rochkind etc., and this prior art has been instructed and use the laser energy in some specific application.Dew discloses the purposes of a kind of laser (the Nd:YAG laser of operating specifically) under second wavelength of 1,320 nanometer.Dew discloses Nd:YAG laser and has operated in 1,060 nanometer usually.The purpose of Dew patent is to use laser to make wound closure and reconstruct biological tissue.Laser can change into heat, and heat is organized the most at last and fragmented into the collagen composition that serves as " biological adhesive ".
L Esperance has instructed the utilization of two kinds of laser beams that are used for visible red or low infrared and extreme low energy laser irradiation tissue.L Esperanc has instructed use helium-neon or krypton laser.The employed wavelength of L Esperance is the 610-660 nanometer that transmits 15 milliwatt outputs.
Rochkind (application on October 30 nineteen ninety) uses the continuous or discontinuous life-span (life), (has 16 milliwatts/cm but described in 632 nanometers 2Intensity) helium-neon laser of operating or produce 465 or 520 nanometers and (have about 40 milliwatts/cm 2Light intensity) argon type laser.In addition, Rochkind has described the two-step method that realizes the method that invention is looked for; Open and exposure is carried out the first time when organizing and handled at the surgery intra-operative, after stitching, carry out processing second time.
Goal of the invention
Very attempting being used to stimulate soft tissue on low-power (typically fully below the 100 milliwatts) level, stimulate the use of microcirculation with the conventional laser of the purpose of minimizing healing time to reduce pain and inflammation.Although obtained some treatment benefit, treatment time looks unacceptable.
Therefore, the purpose of this invention is to provide does not need for therapeutic purposes safely and effectively reactive laser are applied to living tissue said tissue is exposed to method under the destructive heat effect, described therapeutic purposes for example reduce pain, reduce inflammation and promote organization healing by the stimulation microcirculation with the power of higher level.This method has shortened treatment time known in the art.Summary of the invention
Found that method of the present invention reduces soft tissue pain, reduces inflammation and by stimulating microcirculation to promote organization healing said living tissue not being exposed under the destructive heat effect, described method is used 100 milliwatts low level reaction laser system in the 800 milliwatt scopes, the luminous energy that produces under the basic wavelength of 1,064 nanometer with Nd:YAG laser carries out with pulse or continuation mode.In another approach, luminous energy is that yttrium-lithium-fluoride (Nd:YLF) laser by the coating of the neodymium of 1,055 nano wave length produces, and is perhaps produced by some other laser in 1,000 to 1,150 nanometer preferred wavelength range.Organize at wavelength and power and to use the optical energy irradiation living tissue on the dissipation level, so that the amount that produces the luminous energy be absorbed and be converted to heat is in the mean temperature of the tissue that is enough to be shone is brought up to minimal absorption rate institute restricted portion on the basal body temperature, but the absorbance when being lower than the metaplasia collastromin.Careful control wavelength, site, beam size, power, open-assembly time, so that produce tangible heat effect in the tissue that is shone, but this effect is the limited tissue injury to avoid heat effect to produce.
The prior art that does not have to be quoted has been instructed the present invention.Propose as this description, Nd:YAG laser is operated under the fundamental wavelength (power with 80-100 milliwatt) of its 1,064 nanometer.Perhaps Nd:YLF laser is operated under the wavelength (having identical power bracket) of 1,055 nanometer.L Esperance and Rochkind do not have instruction to use Nd:YAG laser in this specific mode.L Esperance and Rochkind describe the preferred operational approach of a half-wavelength of the present invention approximately in detail.In fact, L Esperance has utilized two light beams but not a light beam.There is not the purposes of the open Nd:YAG laser of prior art at its 1,064 nanometer fundamental wavelength place.
Following table has compared technology and the present invention of Dew, L-Esperance and Rochkind.
Patent Type of laser Wavelength (NM) Power (MW) Purposes
Dew Nd：YAG 1,320 1000-5000 Scapel
L′Esperance He-Ne 633 15 Treatment
Rochkind He-Ne Ar 632 520 16 80 Treatment
Bellinger Nd：YAG 1,064 100-800 Treatment
Although L ' Esperance can instruct the method for Rochkind, even there is not prior art hint Nd:YAG laser to use and to obtain required result with very big power by this way.
The description of preferred embodiment
According to preferable methods, described laser can be produced by Nd:YAG laser with 100-800 milliwatt output level and 1.064 nanometer fundamental wavelengths.The needs that described laser light energy applied to health reduce muscle spasm, increase the zone of circulating, reducing pain or accelerating organization healing.Define surf zone, (have and be limited in about erg-ten/cm with the time and intensity of aequum 2To about 15 joules/cm 2The illuminated energy density of organizing of scope) with the laser beam irradiation tissue surface to produce required therapeutical effect.The intensity of treatment and time length are determined by the degree of depth of tissue to be treated, required intrusion, the severe degree of damage and patient's situation.
In order to reduce pain, reduce inflammation and through stimulating microcirculation to accelerate the purpose of organization healing, the treatment processing method of a low level reaction laser system to be described, all processes are successfully carried out under the situation that does not produce disorganization effect hot in nature.A Nd:YAG laser resonator is as lasing light emitter.Its fundamental wavelength is 1,061 nanometer, and has the tunable optical beam energy output of 100 milliwatts-800 milliwatt.Described laser can be operated with pulse or continuation mode, and its output is by the control of the exposure intervalometer in 0.1-9.9 minute scope.Pulse turn-on time is adjustable in the 0.1-9.9 scope of second with 0.1 second blanking time.Pulse turn off time is also adjustable in the 0.1-9.9 scope of second with 0.1 second blanking time.The Nd:YAG laser beam is operated in the electromagnetic spectrum infrared part (being sightless therefore) of 1,064 nanometer.The method that light beam is sent in the target scope is to adopt the head of softish quartz fibre and focusing.
The Nd:YAG laser beam breaks away from the output coupler of laser head, and before by the variable intermediate density attenuator of circulation by the wedge guiding of a pair of arrangement.The light that passes attenuator is by the long lens focus of a pair of 90 millimeters focuses on the immediate end of optical fiber cable.
Main beam attenuator is the shutter that is placed on the laser head outside between output coupler and the light beam guiding mirror.It comprises four assemblies: 90 degree reflections prismatic, shutter arm, shutter mounting bracket and promotion solenoid.Prism is installed on the shutter arm, so as on the position of closing usually prismatic intercepting laser light beam, and it is reflexed to light beam storage bay (dump) in the Laser Slabs downwards.Selected when output channel, and pedal is when being depressed (it causes the shutter arm to improve and makes light beam improve), and solenoid has energy.When the solenoid arm deenergized, shutter dropped to the position of cutting out.
Luminous energy is produced by a kind of successive light source, and preferably the laser by 1,064 nano wave length in the near infrared region of electromagnetic spectrum produces.Laser is provided by the fiber optics guider and the bonder that instruct the luminous energy light beam to tissue surface.The energy of control light radiation, and be used for being created in the minimal absorption rate of the tissue that is shone, this absorbance is brought up to the mean temperature of irradiation tissue on the basal body temperature level, but it is no more than maximum absorbance (it is big must be enough to will be shone metaplasia collastromin).
Definite by test widely, under the main wavelength of 1,064 nanometer of the level of 100-800 milliwatt power output, on the treatment site, to produce about 1.0 joules/cm 2With 15 joules/cm 2The laser beam of the focusing of the emission laser beam energy density in the scope can satisfy above-mentioned condition when operating Nd:YAG laser.
When using said method, observed some physiological mechanism in tissue and on cellular level.In microcirculqtory system was estimated, for example, the blood blood vessel wall had photonasty and is proved to be.When the blood blood vessel wall was exposed to laser emission set forth above, anxiety was suppressed in smooth muscle cell, like this, and blood flow increasing in capillary tube.Observed other effect is: capillary neovascularization, the blood platelet aggregation of periphery weakens, trivalent is to the O of unit price form 2Reduction (thus make tissue have bigger Oxygenation), buffer substance concentration reduces in blood, deformable index is stable, the snperoxiaized lipid oxidation product of blood reduces.Observed other effect is that the antithrombin activity index increases, the stimulation of antioxidant system enzyme (as superoxide dismutase and catalase).Observe from vein and the lymph and the effluent increase in the zone of being shone.Tissue permeability in above-mentioned zone is improved in fact.This helps to reduce at once edema and hematoma concentrate in tissue.On cellular level, notice that also mitochondrion produces the ADP of recruitment, increase ATP thereafter and produce.Also as if increased the stimulation of the calcium on cellular level and sodium pump in the tissue film.
On the neuron level, observed the result's who handles as aforementioned therapies following effect.At first, the effect potentiality that have the increase of crushing and complete nerve.Blood supply and aixs cylinder quantity increase on the zone of being shone.When tissue is treated, notice the inhibitory action of scar tissue.There is the increase immediately of neurolemma permeability.Calcium by nerve and potassium ion permeability have been observed at least 120 days secular change.The production of RNA and DNA subsequently increases.Produce unit price oxygen (it is an important factor) in cell regeneration.Pathology degeneration with nerve injury changes over regeneration.Astrocyte and oligodendroglia are upset, and cause nervus peripheralis aixs cylinder and myelinic production to increase.
The phagocytolysis of blood increases, and then reduces in fact and infect.Also demonstrate tangible anti-inflammatory phenomenon, it makes the inflammation of tendon, nerve, joint capsule reduce, and produces the collagen of strengthening simultaneously.Influence to the grain structure of obvious increase is also arranged in wound closure under limited cycling condition.
Observe the analgesia of tissue and organized a series of activities of the complexity on the level to interrelate.On local horizontal, weakening of inflammation arranged, cause the absorption again of exudate.Enkephalin and endorphins are replenished, the generation of adjusting pain on spinal levels and in the human brain.The serotnogenic approach is also replenished.Though be not clear fully, the irradiation that it is believed that tissue causes the answer (this is the reason that pain weakens) of the energy balance on cellular level.
In another approach, laser can be that Nd:YAG laser by the wavelength of 1,055 nanometer produces.Other laser can be used or be developed, so that operate in the preferred range of about 1,150 nanometer about 1,000 with identical power level.
Although described the present invention with reference to preferable methods with reference to particular therapeutic, above description is not the explanation that is used for carrying out on the restrictive, sense.To those skilled in the art, the content presentation of above description modification and other application of the present invention of disclosed embodiment.Therefore, it should be noted that claims fall within any such modification or embodiment in the true scope of the present invention with covering.

Claims (20)

1. one kind is used for the treatment of the little treatment region of vivo biological tissue and does not need said tissue is exposed to method under the damaging heat effect, and said method comprises:
Produce successive light ray radiation with a kind of low level reaction laser, this radiation has the wavelength in the scope of electromagnetic spectrum near infrared region, its output about 100 milliwatts in the scope of about 800 milliwatts and
Said successive light ray radiation is focused on said little treatment region, so that in the tissue that is shone, absorb and the maximum rate of the ratio that the changes into heat ratio when being enough to make the mean temperature of being organized by radiation bring up to the minimum rate on the live body basal body temperature level and being lower than the metaplasia collastromin that is shone between scope in, the density of wherein said light ray radiation in the tissue site of being shone is at about 1.0 joules/cm 2To about 15 joules/cm 2Scope in.
2. according to the process of claim 1 wherein that said wavelength is about 1,064 nanometer.
3. according to the method for claim 2, wherein said low level reaction laser comprises Nd:YAG laser.
4. according to the method for claim 3, wherein shine said tissue with said successive light ray radiation with the time and intensity that the therapeutic effect aequum is provided on the many little treatment region in grid.
5. according to the method for claim 3, wherein each little treatment region has at about 0.5mm 2To about 2mm 2Scope in the zone.
6. according to the method for claim 3, wherein said low level reaction laser with turn-on time in 0.1 to 9.9 second scope, turn-off time, each pulse in 0.1 to 9.9 second scope came pulse.
7. according to the method for claim 3, wherein operate said low level reaction laser in the mode that keeps.
8. according to the process of claim 1 wherein that said wavelength is about 1,055 nanometer.
9. according to the method for claim 4, wherein said low level reaction laser comprises Nd:YLF laser.
10. according to the method for claim 9, wherein shine said tissue with said successive light ray radiation with the time and intensity that the therapeutic effect aequum is provided on the many little treatment region in grid.
11. according to the method for claim 9, wherein each little treatment region has at about 0.5mm 2To about 2mm 2Scope in the zone.
12. according to the method for claim 9, wherein said low level reaction laser with turn-on time in 0.1 to 9.9 second scope, turn-off time, each pulse in 0.1 to 9.9 second scope came pulse.
13., wherein operate said low level reaction laser in the mode that keeps according to the method for claim 9.
14. according to the process of claim 1 wherein that said low level reaction laser comprises Nd:YAG laser.
15. according to the process of claim 1 wherein that said low level reaction laser comprises Nd:YLF laser.
16. according to shining said tissue with said successive light ray radiation with the time and intensity that the therapeutic effect aequum is provided on the many little treatment region that the process of claim 1 wherein in grid.
17. according to the process of claim 1 wherein that each point of care has at about 0.5mm 2To about 2mm 2Scope in the zone.
18. according to the process of claim 1 wherein said low level reaction laser with turn-on time in 0.1 to 9.9 second scope, turn-off time, each pulse in 0.1 to 9.9 second scope came pulse.
19. operate said low level reaction laser in the mode that keeps according to the process of claim 1 wherein.
20. according to the process of claim 1 wherein that said wavelength arrives in the scope of about 1,150 nanometer in about 1,000 nanometer.
CN95197798A 1995-03-31 1995-03-31 Biological tissue stimulation by optical energy Pending CN1179727A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110520194A (en) * 2017-03-16 2019-11-29 奥哈伊视网膜技术有限责任公司 Use the method for pulse energy heat treatment biological tissue

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951596A (en) * 1991-07-01 1999-09-14 Laser Biotherapy Inc Biological tissue stimulation by optical energy
US5445146A (en) * 1995-03-31 1995-08-29 Bellinger; Gary J. Biological tissue stimulation by low level optical energy
US5755752A (en) * 1992-04-24 1998-05-26 Segal; Kim Robin Diode laser irradiation system for biological tissue stimulation
US7537605B2 (en) 1993-10-04 2009-05-26 Huan-Chen Li Medical device for treating skin itch and rash
US5914345A (en) * 1994-10-11 1999-06-22 Endoluminal Therapeutics, Inc. Treatment of tissues to reduce subsequent response to injury
DE29508077U1 (en) * 1995-05-16 1995-08-10 Wilden Lutz Dr Med Oral care device
US7229436B2 (en) 1996-01-05 2007-06-12 Thermage, Inc. Method and kit for treatment of tissue
DE69736533T2 (en) * 1996-01-12 2007-05-03 Kabushiki Kaisha Topcon Apparatus and method for generating a laser beam
US6443974B1 (en) 1996-07-28 2002-09-03 Biosense, Inc. Electromagnetic cardiac biostimulation
US5810801A (en) 1997-02-05 1998-09-22 Candela Corporation Method and apparatus for treating wrinkles in skin using radiation
US20090069872A1 (en) * 1997-02-10 2009-03-12 El. En. S.P.A. Device and method for biological tissue stimulation by high intensity laser therapy
DE29724780U1 (en) * 1997-09-25 2004-02-26 Ruschke, Thomas Electromagnetic oscillation amplifier especially a laser for biological system treatment
GB9721506D0 (en) * 1997-10-10 1997-12-10 Virulite Limited Treatment of diseases
US6030374A (en) * 1998-05-29 2000-02-29 Mcdaniel; David H. Ultrasound enhancement of percutaneous drug absorption
US6398753B2 (en) 1998-04-03 2002-06-04 Mcdaniel David H. Ultrasound enhancement of percutaneous drug absorption
US7004933B2 (en) 1998-05-29 2006-02-28 Light Bioscience L.L.C. Ultrasound enhancement of percutaneous drug absorption
IL124722A0 (en) * 1998-06-02 1999-01-26 Oron Amir Ischemia laser treatment
US6887260B1 (en) * 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
US6936044B2 (en) * 1998-11-30 2005-08-30 Light Bioscience, Llc Method and apparatus for the stimulation of hair growth
US20060212025A1 (en) * 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
US6663659B2 (en) 2000-01-13 2003-12-16 Mcdaniel David H. Method and apparatus for the photomodulation of living cells
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US6283956B1 (en) * 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US6676655B2 (en) 1998-11-30 2004-01-13 Light Bioscience L.L.C. Low intensity light therapy for the manipulation of fibroblast, and fibroblast-derived mammalian cells and collagen
WO2000035534A1 (en) 1998-12-12 2000-06-22 Virulite Limited Electromagnetic radiation therapy
US6436129B1 (en) * 1999-01-20 2002-08-20 Oratec Interventions, Inc. Method and apparatus for stimulating nerve regeneration
US6214035B1 (en) 1999-03-23 2001-04-10 Jackson Streeter Method for improving cardiac microcirculation
US6267779B1 (en) 1999-03-29 2001-07-31 Medelaser, Llc Method and apparatus for therapeutic laser treatment
US6413267B1 (en) * 1999-08-09 2002-07-02 Theralase, Inc. Therapeutic laser device and method including noninvasive subsurface monitoring and controlling means
KR100336660B1 (en) * 1999-09-22 2002-05-13 최좌진 a low energy laser theraphy system and method for controling the same
US6921413B2 (en) * 2000-08-16 2005-07-26 Vanderbilt University Methods and devices for optical stimulation of neural tissues
US6592611B1 (en) * 2000-10-10 2003-07-15 Robert H. Zawada Violation of time reversal invariance in living tissue
DE10055677A1 (en) * 2000-11-05 2002-05-16 Clyxon Laser Gmbh Method and device for cleaning wounds by laser
US6673095B2 (en) 2001-02-12 2004-01-06 Wound Healing Of Oklahoma, Inc. Apparatus and method for delivery of laser light
AUPR442101A0 (en) * 2001-04-12 2001-05-17 Taracan Pty Ltd Laser photocoagulator
US20040260210A1 (en) * 2003-06-23 2004-12-23 Engii (2001) Ltd. System and method for face and body treatment
US20040260209A1 (en) * 2003-06-23 2004-12-23 Engli (2001) Ltd. System and method for face and body treatment
US20030109906A1 (en) * 2001-11-01 2003-06-12 Jackson Streeter Low level light therapy for the treatment of stroke
US7303578B2 (en) 2001-11-01 2007-12-04 Photothera, Inc. Device and method for providing phototherapy to the brain
US10683494B2 (en) * 2001-11-01 2020-06-16 Pthera LLC Enhanced stem cell therapy and stem cell production through the administration of low level light energy
US8308784B2 (en) 2006-08-24 2012-11-13 Jackson Streeter Low level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease
US7534255B1 (en) 2003-01-24 2009-05-19 Photothera, Inc Low level light therapy for enhancement of neurologic function
US9993659B2 (en) * 2001-11-01 2018-06-12 Pthera, Llc Low level light therapy for enhancement of neurologic function by altering axonal transport rate
US7177695B2 (en) 2001-12-17 2007-02-13 Cefamoptec Industries, Inc. Early stage wound healing using electromagnetic radiation
US20030144712A1 (en) * 2001-12-20 2003-07-31 Jackson Streeter, M.D. Methods for overcoming organ transplant rejection
US10695577B2 (en) 2001-12-21 2020-06-30 Photothera, Inc. Device and method for providing phototherapy to the heart
US7316922B2 (en) * 2002-01-09 2008-01-08 Photothera Inc. Method for preserving organs for transplant
US20040153130A1 (en) * 2002-05-29 2004-08-05 Amir Oron Methods for treating muscular dystrophy
GB0217273D0 (en) * 2002-07-25 2002-09-04 Diomed Ltd Laser system
US20040132002A1 (en) * 2002-09-17 2004-07-08 Jackson Streeter Methods for preserving blood
US6866678B2 (en) 2002-12-10 2005-03-15 Interbational Technology Center Phototherapeutic treatment methods and apparatus
US11007373B1 (en) 2002-12-20 2021-05-18 James Andrew Ohneck Photobiostimulation device and method of using same
US7344555B2 (en) * 2003-04-07 2008-03-18 The United States Of America As Represented By The Department Of Health And Human Services Light promotes regeneration and functional recovery after spinal cord injury
KR20060041161A (en) 2003-04-10 2006-05-11 라이트 바이오사이언스, 엘엘씨 Photomodulation methods and devices for regulating cell proliferation and gene expression
US7137979B2 (en) * 2003-05-31 2006-11-21 Tyrell, Inc. Methods and devices for the treatment of skin lesions
KR101160343B1 (en) * 2003-07-31 2012-06-26 젠틀웨이브즈 엘엘씨. System and method for the photodynamic treatment of burns, wounds, and related skin disorders
US20050065577A1 (en) * 2003-09-23 2005-03-24 Mcarthur Frank G. Low level laser tissue treatment
JP2007520285A (en) 2004-02-06 2007-07-26 バロレ，ダニエル Method and apparatus for treating mammalian tissue
GB0414113D0 (en) * 2004-06-24 2004-07-28 Virulite Distrib Ltd Cosmetic uses of electromagnetic radiation
US8277495B2 (en) 2005-01-13 2012-10-02 Candela Corporation Method and apparatus for treating a diseased nail
US7722656B1 (en) 2005-02-25 2010-05-25 Kim Robin Segal Device and method for stimulating hair growth
US20060229689A1 (en) * 2005-04-08 2006-10-12 Led Technologies, Llc LED therapy device
US20070049998A1 (en) * 2005-05-18 2007-03-01 Tyrell, Inc. Treatment device and method for treating skin lesions through application of heat
GB0512038D0 (en) * 2005-06-14 2005-07-20 Dougal Gordon Therapeutic and cosmetic uses of electromagnetic radiation
US7736382B2 (en) 2005-09-09 2010-06-15 Lockheed Martin Corporation Apparatus for optical stimulation of nerves and other animal tissue
WO2007038567A1 (en) 2005-09-28 2007-04-05 Candela Corporation Treating cellulite
US20080077200A1 (en) 2006-09-21 2008-03-27 Aculight Corporation Apparatus and method for stimulation of nerves and automated control of surgical instruments
US8475506B1 (en) 2007-08-13 2013-07-02 Lockheed Martin Corporation VCSEL array stimulator apparatus and method for light stimulation of bodily tissues
US8744570B2 (en) * 2009-01-23 2014-06-03 Lockheed Martin Corporation Optical stimulation of the brainstem and/or midbrain, including auditory areas
US8012189B1 (en) 2007-01-11 2011-09-06 Lockheed Martin Corporation Method and vestibular implant using optical stimulation of nerves
US8956396B1 (en) 2005-10-24 2015-02-17 Lockheed Martin Corporation Eye-tracking visual prosthetic and method
US8945197B1 (en) 2005-10-24 2015-02-03 Lockheed Martin Corporation Sight-restoring visual prosthetic and method using infrared nerve-stimulation light
US8929973B1 (en) 2005-10-24 2015-01-06 Lockheed Martin Corporation Apparatus and method for characterizing optical sources used with human and animal tissues
US8792978B2 (en) 2010-05-28 2014-07-29 Lockheed Martin Corporation Laser-based nerve stimulators for, E.G., hearing restoration in cochlear prostheses and method
US8709078B1 (en) 2011-08-03 2014-04-29 Lockheed Martin Corporation Ocular implant with substantially constant retinal spacing for transmission of nerve-stimulation light
US7891362B2 (en) 2005-12-23 2011-02-22 Candela Corporation Methods for treating pigmentary and vascular abnormalities in a dermal region
US8033284B2 (en) * 2006-01-11 2011-10-11 Curaelase, Inc. Therapeutic laser treatment
US7575589B2 (en) * 2006-01-30 2009-08-18 Photothera, Inc. Light-emitting device and method for providing phototherapy to the brain
US20090254154A1 (en) * 2008-03-18 2009-10-08 Luis De Taboada Method and apparatus for irradiating a surface with pulsed light
US10357662B2 (en) * 2009-02-19 2019-07-23 Pthera LLC Apparatus and method for irradiating a surface with light
US8251982B2 (en) * 2006-04-14 2012-08-28 Asa S.R.L. Laser apparatus for therapeutic applications
US20070259316A1 (en) * 2006-05-08 2007-11-08 Tyrell, Inc. Treatment device and method for treating or preventing periodontal disease through application of heat
US20080008978A1 (en) * 2006-05-08 2008-01-10 Tyrell, Inc. Treatment device and method for treating or preventing periodontal disease through application of heat
US8136531B2 (en) * 2006-05-08 2012-03-20 Chariff Mark D Device and method for treating musculo-skeletal injury and pain by application of laser light therapy
US8246611B2 (en) 2006-06-14 2012-08-21 Candela Corporation Treatment of skin by spatial modulation of thermal heating
US8996131B1 (en) 2006-09-28 2015-03-31 Lockheed Martin Corporation Apparatus and method for managing chronic pain with infrared light sources and heat
US8498699B2 (en) * 2008-10-03 2013-07-30 Lockheed Martin Company Method and nerve stimulator using simultaneous electrical and optical signals
US20080172105A1 (en) * 2007-01-17 2008-07-17 Ws Far Ir Medical Technology Co., Ltd. Method for preventing and/or ameliorating inflammation
US7883536B1 (en) 2007-01-19 2011-02-08 Lockheed Martin Corporation Hybrid optical-electrical probes
US20080221211A1 (en) * 2007-02-02 2008-09-11 Jackson Streeter Method of treatment of neurological injury or cancer by administration of dichloroacetate
US20090048590A1 (en) * 2007-08-15 2009-02-19 Tyrell, Inc. Systems and methods for treating nail-bed fungus through application of heat
US8840654B2 (en) 2011-07-22 2014-09-23 Lockheed Martin Corporation Cochlear implant using optical stimulation with encoded information designed to limit heating effects
BE1017986A3 (en) * 2008-02-13 2010-03-02 Lefebvre Guy Estimating ratio between fat and water contents of substance, preferably animal tissues and to deduce fat mass and lean mass, comprises simultaneously measuring three infrared lines radiated and injected into the substance/tested tissues
US20090259220A1 (en) * 2008-04-09 2009-10-15 Angiodynamics, Inc. Treatment Devices and Methods
GB0812753D0 (en) * 2008-07-14 2008-08-20 Dougal Gordon R P Electromagnetic radiation and its therapeutic effect
US20100016732A1 (en) * 2008-07-17 2010-01-21 Lockheed Martin Corporation Apparatus and method for neural-signal capture to drive neuroprostheses or control bodily function
WO2010031777A2 (en) 2008-09-16 2010-03-25 El.En. S.p.A Device and method for regenerative therapy by high intensity laser therapy
US7848035B2 (en) * 2008-09-18 2010-12-07 Photothera, Inc. Single-use lens assembly
WO2010040142A1 (en) 2008-10-03 2010-04-08 Lockheed Martin Corporation Nerve stimulator and method using simultaneous electrical and optical signals
US20110190749A1 (en) 2008-11-24 2011-08-04 Mcmillan Kathleen Low Profile Apparatus and Method for Phototherapy
EP2361117A4 (en) * 2008-11-24 2012-05-09 Gradiant Res Llc Photothermal treatment of soft tissues
US20110172746A1 (en) * 2010-01-12 2011-07-14 Roger Porter High Level Laser Therapy Apparatus and Methods
BR112013006408A2 (en) * 2010-09-30 2016-07-05 Wavelight Gmbh apparatus and method for processing focused electromagnetic radiation material
EP2624777B1 (en) * 2010-10-07 2019-03-20 Gradiant Research, Llc Apparatus for skin cancer thermal therapy
MX348442B (en) 2011-03-23 2017-06-12 Antonio De Garay Arellano David Improvements to system for using whitewater and soapy water in places of residence.
US20160296764A1 (en) * 2014-07-01 2016-10-13 Gary John Bellinger Non-invasive and non-ablative soft tissue laser therapy
US20150182755A1 (en) * 2012-12-31 2015-07-02 Gary John Bellinger Biological Tissue Stimulation of the Auto Immune System Cellular Reaction by Using Optical Energy
US10589120B1 (en) * 2012-12-31 2020-03-17 Gary John Bellinger High-intensity laser therapy method and apparatus
US9907975B1 (en) 2014-11-19 2018-03-06 Roger D. Porter Therapeutic laser treatment and transdermal stimulation of stem cell differentiation
US11344707B2 (en) 2016-11-28 2022-05-31 Therma Bright Inc. Devices for applying a topical treatment
US20200384253A1 (en) * 2016-11-28 2020-12-10 The Jenex Corporation Devices for applying a topical treatment

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1135956A (en) 1966-01-07 1968-12-11 Int Research & Dev Co Ltd Improvements in and relating to instruments for the medical treatment of human and animal tissue using lasers
US3720213A (en) 1971-02-05 1973-03-13 Coherent Radiation Laser photocoagulator
US4144888A (en) 1976-09-15 1979-03-20 Malyshev Boris N Device for treatment by laser emission
US4141362A (en) 1977-05-23 1979-02-27 Richard Wolf Gmbh Laser endoscope
JPS5921767Y2 (en) 1979-10-22 1984-06-28 オリンパス光学工業株式会社 Endoscope
JPS5886178A (en) 1981-11-18 1983-05-23 松下電器産業株式会社 Laser medical apparatus
JPS5886787A (en) 1981-11-19 1983-05-24 Nippon Sekigaisen Kogyo Kk Laser emitting device
US4672969A (en) 1983-10-06 1987-06-16 Sonomo Corporation Laser healing method
US4854320A (en) * 1983-10-06 1989-08-08 Laser Surgery Software, Inc. Laser healing method and apparatus
US5002051A (en) * 1983-10-06 1991-03-26 Lasery Surgery Software, Inc. Method for closing tissue wounds using radiative energy beams
JPS60137342A (en) 1983-12-27 1985-07-20 オリンパス光学工業株式会社 Electronic scope
US4589404A (en) 1984-01-03 1986-05-20 Medical Dynamics, Inc. Laser endoscope
US4601288A (en) 1984-02-24 1986-07-22 Myers John D Laser device and method
JPH0235288Y2 (en) 1984-10-06 1990-09-25
EP0184928B1 (en) 1984-12-06 1990-08-16 Hughes Technology Pty Ltd. Hygienic attachments for therapy lasers
IL82830A (en) * 1987-06-09 1992-03-29 Simeone Rochkind Apparatus for inducing functional regeneration of nerve fibres at an injured site of the spinal cord
US4930504A (en) * 1987-11-13 1990-06-05 Diamantopoulos Costas A Device for biostimulation of tissue and method for treatment of tissue
US4931053A (en) * 1988-01-27 1990-06-05 L'esperance Medical Technologies, Inc. Method and apparatus for enhanced vascular or other growth
US5161526A (en) * 1989-04-04 1992-11-10 Hellwing Isak A Method of treating of bleeding in hemophiliacs
US5445146A (en) * 1995-03-31 1995-08-29 Bellinger; Gary J. Biological tissue stimulation by low level optical energy

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110520194A (en) * 2017-03-16 2019-11-29 奥哈伊视网膜技术有限责任公司 Use the method for pulse energy heat treatment biological tissue
CN110520194B (en) * 2017-03-16 2024-03-26 奥哈伊视网膜技术有限责任公司 Method for thermally treating biological tissue using pulse energy

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