CN1179727A - Biological tissue stimulation by optical energy - Google Patents

Biological tissue stimulation by optical energy Download PDF

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CN1179727A
CN1179727A CN 95197798 CN95197798A CN1179727A CN 1179727 A CN1179727 A CN 1179727A CN 95197798 CN95197798 CN 95197798 CN 95197798 A CN95197798 A CN 95197798A CN 1179727 A CN1179727 A CN 1179727A
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method according
laser
range
tissue
low level
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CN 95197798
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G·J·比林格
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激光生物治疗公司
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01MCATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M1/00Stationary means for catching or killing insects
    • A01M1/02Stationary means for catching or killing insects with devices or substances, e.g. food, pheronones attracting the insects
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01MCATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M1/00Stationary means for catching or killing insects
    • A01M1/02Stationary means for catching or killing insects with devices or substances, e.g. food, pheronones attracting the insects
    • A01M1/04Attracting insects by using illumination or colours
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01MCATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M1/00Stationary means for catching or killing insects
    • A01M1/10Catching insects by using Traps
    • A01M1/106Catching insects by using Traps for flying insects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/0616Skin treatment other than tanning
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01MCATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M2200/00Kind of animal
    • A01M2200/01Insects
    • A01M2200/012Flying insects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017Electrical control of surgical instruments
    • A61B2017/00137Details of operation mode
    • A61B2017/00141Details of operation mode continuous, e.g. wave
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017Electrical control of surgical instruments
    • A61B2017/00137Details of operation mode
    • A61B2017/00154Details of operation mode pulsed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0658Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659Radiation therapy using light characterised by the wavelength of light used infra-red
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/067Radiation therapy using light using laser light

Abstract

The method of using a low level reactive laser system from 100 milliwatts to 800 milliwatts in either a pulsed or continuous mode with optical energy produced by a Nd: YAG laser at a fundamental wavelength of 1064 nanometers has been found to reduce pain in soft tissues, reduce inflammation and enhance the healing of tissue by stimulation of microcirculation without subjecting the living tissue to damaging thermal effects.

Description

用光能刺激生物组织的方法 Light will stimulate the biological tissue

本发明的背景1.发明领域本发明总的来说涉及经光辐射治疗活生物组织的方法,具体地说,本发明涉及用激光辐射刺激软的活组织的方法。 BACKGROUND 1. Field of the Invention The present invention relates generally to a method of optical radiation by living organism tissue treatment, and more particularly, the present invention relates to a method of soft radiation stimulation of living tissue with a laser.

2.背景技术描述各种非手术方法已用于活组织的治疗处理。 2. Description of Background Art Various non-surgical methods have been used for therapeutic treatment of living tissue. 这种技术包括使用超声波能、电刺激、以透热疗法、X射线和微波照射进行的高频刺激。 Such techniques include the use of ultrasonic energy, electrical stimulation, high frequency stimulation to diathermy, X-rays and microwave irradiation performed. 电刺激、透热疗法、X光和微波照射之类的技术对软组织已显示出某些治疗优点。 Electrical stimulation, diathermy, X microwave irradiation light such soft tissue techniques have shown some therapeutic advantages. 然而,由于过度的热作用造成的组织损伤,它们的使用受到某种程度的限制。 However, due to tissue damage caused by excessive thermal effect, their use is limited to some extent. 因而,用涉及透热疗法、X射线,微波和电刺激的治疗处理有关的能量水平已被限制在如此低的水平上以致于只能获得很少的益处或者根本不能获得益处。 Thus, the energy levels with a therapeutic treatment involving diathermy, X-ray, microwave and electrical stimulation has been associated restrictions on such a low level so that the benefits can only get little or no access to benefits. 此外,必须细心地控制微波和X-射线辐射的剂量或暴露以避免出现与所述的辐射相关的健康问题。 In addition, the dose must be carefully controlled microwave and X- ray radiation or the radiation exposure in order to avoid the associated health problems. 超声波能不被优先吸收并且影响所有周围的组织。 Ultrasound can not be preferentially absorbed and affects all the surrounding tissue.

由激光产生的光能已被应用于各种医学和外科目的,由于激光光线的单色与连续的性质,依据所照射的组织的性质和光线的波长的某些特征(包括反射率、吸收系数、散射系数、热传导率以及热扩散常数),其可以被活组织选择性地吸收。 Energy produced by the laser has been used in various medical and surgical purposes, certain features of the wavelengths and the nature of the laser light beam is monochromatic continuous nature, according to the irradiated tissue (including reflectivity, absorption coefficient , scattering coefficient, thermal conductivity and thermal diffusion constant), which can be selectively absorbed living tissue. 反射率、吸收系数和散射系数取决于光辐射的波长。 Reflectivity, absorption coefficient and scattering coefficient depends on the wavelength of the optical radiation. 已知吸收系数依赖于带内(interband)跃迁、自由电子吸收、栅格吸收(声子吸收)和杂质吸收之类的因素(其取决于光辐射的波长)。 It is known to depend on the absorption coefficient of the band (Interband) transition, free electron absorption, grid absorption (phonon absorption), and the absorption of impurity elements like (which depends on the light wavelength of the radiation).

在活组织中,水是一个在红外范围中有吸收带(按照水分子的振动)的主要的组分。 In living tissue, water is a range in the infrared absorption band of the main component (in accordance with the vibration of water molecule). 由于血红蛋白的存在,在可见范围中存在吸收。 Due to the presence of hemoglobin, the presence of absorption in the visible range. 而且,在活组织中的散射系数是一个占主要地位的因素。 Moreover, the scattering coefficient in living tissue is a dominant factor.

这样,对于一种给定的组织类型而言,激光光线可以通过组织传播,基本上不衰减,或者几乎可以被彻底地吸收。 Thus, for a given tissue type, the laser beam can propagate through the tissue, substantially unattenuated, or may be almost completely absorbed. 组织被加热并最终被破坏的程度取决于它吸收光能的程度。 Extent of tissue is heated and ultimately destroyed depends on the extent it absorbs light energy. 一般来说,激光光线最好是在希望不受影响的组织中基本上被传送,在待受影响的组织中被吸收。 Generally, the laser beam is preferably transmitted substantially unaffected in the desired tissue, it is absorbed in the tissue to be affected. 例如,当在由血液或水润湿的组织处使用激光辐射时,希望光能不被水或血液吸收,从而使激光能特异性地针对待治疗的组织。 For example, when a laser radiation at the tissue wetted by water or blood, desired energy is not absorbed by water or blood, so that the laser can be specific for the tissue to be treated. 激光治疗的另一个优点是光能可以以精确的、非常有限的位置和以预定的有限的能量水平被传送到治疗组织。 Another advantage of laser treatment is that the optical energy can be accurately, and in a very limited predetermined position limited energy level transmitted to the treatment tissue.

已知红宝石和氩激光发射电磁光谱可见部分的光能,并且已成功地用于眼科学领域,以便将视网膜再连接到下面的脉络膜上,和经穿过眼睛前面的部分减少眼间压力来治疗青光眼。 Known ruby ​​and argon laser emitting the visible light portion of the electromagnetic spectrum, and have been successfully used in the field of ophthalmology, in order to re-connect the retina to the underlying choroid, and partially through the front of the eye through the interocular pressure reducing treatment glaucoma. 红宝石激光能具有694纳米的波长,在可见光谱的红色部分。 Ruby laser energy has a wavelength of 694 nm, in the red portion of the visible spectrum. 氩激光发射在488和515纳米的能量,因此出现在可见光谱的蓝绿色部分。 An argon laser emitting at 488 and 515 nm energy, thus appears in the blue-green portion of the visible spectrum. 红宝石和氩激光光束很少地被水吸收,但被血液色原体血红蛋白强烈吸收。 Ruby and argon laser beams rarely absorbed by water, but is strongly absorbed by blood chromogen hemoglobin. 这样,红宝石和氩激光能很少被非着色的组织(如眼角膜,透镜以及玻璃体)吸收,但是较好地被着色的视网膜吸收,其然后在此发生热作用。 Thus, the ruby ​​and argon laser energy is rarely non-colored tissue (e.g., cornea, lens, and vitreous) absorption, but preferably pigmented retina absorbed, then the action of heat which occurs here.

已在外科手术中采用的另一种激光类型是二氧化碳(CO2)气体激光,其发射强烈地被水吸收的光束。 Another type of laser has been employed in surgery is carbon dioxide (CO2) gas laser which emits a light beam is strongly absorbed by water. CO2激光的波长为10.6微米,因此位于电磁光谱的不可见远红外区,并且不依赖于组织颜色被所有具有高水含量的软组织吸收。 CO2 laser wavelength of 10.6 microns, and therefore non-visible spectrum of the electromagnetic far-infrared region, and is independent of tissue color by all soft tissues having a high absorption of water content. 这样,CO2激光构成了一个良好的外科解剖刀和汽化器。 In this way, CO2 laser constitute an excellent surgical scalpel and vaporizer. 因为它完全被吸收,所以其穿透的深度浅,就所治疗的组织表面而言可被精确地控制。 Because it is completely absorbed, its depth of penetration is shallow, in terms of tissue surface to be treated can be precisely controlled. 因此,CO2激光非常适合用于各种外科方法中,其中其对蒸发或者凝结无色组织是必需的,对邻近组织具有的最小的热破坏。 Accordingly, CO2 laser is well suited for a variety of surgical methods, wherein the evaporation or condensation colorless its organization necessary, to adjacent tissue with minimal thermal damage.

另一个得到广泛利用的激光是钕涂布的钇-铝-石榴石(Nd:YAG)激光。 Another been widely used laser is a neodymium-coated yttrium - aluminum - garnet (Nd: YAG) laser. Nd:YAG激光在电磁光谱的近红外区中其1,320纳米第二波长处具有作用的良好方式。 Nd: YAG laser having a good way to effect in the near infrared region of the electromagnetic spectrum in which the second wavelength of 1,320 nanometers. Nd:YAG光发射被血液吸收的程度高于被水吸收的程度,这使得其在凝结大的出血脉管上有用。 Nd: YAG optical emission is absorbed by blood than the extent of the degree of water absorption, which makes it useful for coagulating large on the bleeding vessels. 在1,320纳米的Nd:YAG激光已通过内窥镜发射来治疗各种胃肠流血损伤,如食管的脉管曲张、消化器官溃疡以及动静脉异常。 In Nd 1,320 nm: YAG laser has been used to treat various gastrointestinal bleeding injury emitted through an endoscope, such as esophageal varices, ulcers and arteriovenous anomalies digestive organs. 这样的激光能的应用非常适合于需要高能热作用的场合(如组织汽化、组织烧灼、凝结)和作为外科手术刀。 Such applications of laser energy are well suited for applications requiring high energy thermal effects (such as tissue vaporization, tissue cauterization, coagulation), and as a surgical scalpel.

下列美国专利公开了通过激光辐射治疗处理活组织的仪器和方法:3,456,651 3,720,213 4,141,362 The following U.S. Patent discloses a process of living tissue by a laser irradiation apparatus and a method of treating: 3,456,651 3,720,213 4,141,362

4,144,888 4,367,729 4,561,4404,573,465 4,589,404 4,601,2884,604,992 4,672,969 4,692,9244,705,036 4,931,053 4,966,144三个专利:Dew,4,672,969.00;L Esperance,Jr.4,931,053.00(1990年6月5日申请);和Rochkind等4,966,144.00(1990年10月30日申请)充分描述了现有技术,这一现有技术教导了在某些特定的应用中使用激光能。 4,561,4404,573,465 4,589,404 4,144,888 4,367,729 4,672,969 4,692,9244,705,036 4,931,053 4,966,144 4,601,2884,604,992 three patents: Dew, 4,672,969.00; L Esperance, Jr.4,931,053.00 (1990 filed. 5 years. 6 dated); and the like Rochkind 4,966,144.00 ( October 30, 1990 application) fully described in the prior art, this prior art teaches the use of laser energy in certain applications. Dew公开了一种激光(具体地说是在1,320纳米的第二波长下进行操作的Nd:YAG激光)的用途。 Dew discloses a laser (specifically, operating at a second wavelength of 1,320 nm Nd: YAG laser) use. Dew公开了Nd:YAG激光通常在1,060纳米进行操作。 Dew discloses a Nd: YAG laser typically operates at 1,060 nanometers. Dew专利的目的是使用激光使得创伤闭合和重构生物组织。 Dew patent is to use the object with laser light such wound closure and reconstruction of biological tissue. 激光能转化成热,热最终将组织断裂成充当″生物粘合剂″的胶原成份。 Laser energy is converted into heat, breaking into the ultimate heat the tissue act as a "biological glue" collagen ingredients.

L Esperance教导了用于可见红或低红外与极端低能激光照射组织中的两种激光光束的利用。 L Esperance teaches use of two types of laser beam for the visible red or low infrared and low-energy laser irradiation extreme tissue. L Esperanc教导了使用氦-氖或者氪激光。 It teaches the use of L Esperanc He - Ne laser or krypton. L Esperance所使用的波长是传送15毫瓦输出功率的610-660纳米。 L Esperance wavelength used is 15 mW output power transmission 610-660 nm.

Rochkind(1990年10月30日申请)使用连续的或不连续的寿命(life),但描述了在632纳米(具有16毫瓦/cm2强度)进行操作的氦-氖激光或者产生465或520纳米(具有约40毫瓦/cm2光强度)的氩型激光。 Helium Rochkind (1990 filed May 30, 10 years) using a continuous or discontinuous life (life), but described in 632 nm (having a 16 mW / cm2 intensity) operation - Ne laser or 520 nm, or 465 to generate an argon laser (about 40 mW / cm2 light intensity). 此外,Rochkind描述了实现发明所寻求的方法的两步法;在外科手术期间打开和暴露组织时进行第一次处理,在缝合后进行第二次处理。 In addition, Rochkind describes the implementation of the method of the invention sought a two step process; performing a first process when opening and exposed tissue during surgery, a second treatment after suturing.

发明目的已在非常低功率(典型地完全在100毫瓦以下)水平上尝试了用于刺激软组织以减少疼痛和发炎,刺激微循环以减少愈合时间之目的的常规激光的使用。 Object of the invention have been attempted at very low power (typically 100 mW or less completely) level for stimulating soft tissue to reduce pain and inflammation, stimulation of microcirculation to reduce healing conventional laser purposes of time. 尽管已取得某些治疗益处,但治疗时间长得不可接受。 While there have been some therapeutic benefit, but the treatment time is unacceptably long.

因此,本发明的目的是提供为了治疗目的安全有效地将反应性激光施用于活组织而不需将所说组织暴露在破坏性的热作用下的方法,所述的治疗目的例如以较高水平的功率减少疼痛、减少发炎,和通过刺激微循环促进组织愈合。 Accordingly, an object of the present invention is to provide a safe and effective for therapeutic purposes reactive laser is applied to the living tissue of said method without exposure to heat tissue destructive effects of said therapeutic purposes at higher levels e.g. power reduce pain, reduce inflammation, and promote healing of tissue by stimulation of microcirculation. 这一方法缩短了本领域已知的治疗时间。 This method shortens treatment time known in the art. 发明概述已发现本发明的方法在不将所说活组织暴露在破坏性的热作用下减少软组织疼痛、减少发炎和通过刺激微循环促进组织愈合,所述方法使用100毫瓦到800毫瓦范围内低水平反应性激光系统,用Nd:YAG激光在1,064纳米的基础波长下产生的光能以脉冲或连续方式进行。 Summary of the Invention The method of the present invention have been found to reduce pain in soft tissues without the action of heat of said living tissue exposed to destructive, reduce inflammation and tissue by stimulation of microcirculation to promote healing, the method uses the range 100 milliwatts to 800 milliwatts the low level reactive laser system with Nd: YAG laser light generated at a base wavelength of 1,064 nm be pulsed or continuous manner. 在另一种方法中,光能是由1,055纳米波长的钕涂布的钇-锂-氟化物(Nd:YLF)激光产生的,或者由在1,000至1,150纳米优选波长范围内的某些其它激光产生的。 In another method, optical energy is applied by a neodymium yttrium 1,055 nm wavelength - Lithium - Fluoride (Nd: YLF) laser-produced, or by some other laser in a wavelength range of preferably 000 to 1,150 nanometers produced. 在波长和功率组织耗散水平上用光能照射活组织,以便产生被吸收和被转化成热的光能的量在足以将所照射的组织的平均温度提高到基础体温之上的最小吸收率所限定的范围内,但低于组织转化成胶原物质时的吸收率。 Living tissue is irradiated with light energy in the wavelength and power dissipation levels organizations, in order to produce an amount of light energy is absorbed and converted to heat sufficient to raise the average temperature of the irradiated tissue to a minimum absorption rate above the basal body temperature within a defined range, but less than the absorption rate of the tissue is converted into collagen materials. 小心控制波长、位点、光束大小、功率、暴露时间,以便在所照射的组织中产生明显的热作用,但该作用是有限的以避免热作用产生的组织损伤。 Careful control of the wavelength, site, beam size, power, exposure time, in order to generate significant heat effect in the irradiated tissue, but this effect is limited to avoid tissue damage produced by the action of heat.

没有所引用的现有技术教导了本发明。 No prior art cited teaches the present invention. 如本说明书所提出的,Nd:YAG激光在其1,064纳米的基本波长(具有80-100毫瓦的功率)下进行操作。 YAG laser operated at its primary wavelength of 1,064 nanometers (80-100 milliwatts) as follows: As set forth in this specification, Nd. 或者Nd:YLF激光在1,055纳米的波长(具有相同的功率范围)下进行操作。 Or a Nd: YLF laser at a wavelength of 1,055 nm (with the same power range) under operation. L Esperance和Rochkind都没有教导以这种特定的方式使用Nd:YAG激光。 L Esperance and Rochkind do not teach in this specific way using Nd: YAG laser. L Esperance和Rochkind都详细描述了约本发明的一半波长的优选的操作方法。 L Esperance and Rochkind describes a wavelength of about half of the present invention in detail preferred method of operation. 事实上,L Esperance利用了两个光束而非一个光束。 In fact, L Esperance utilizes two beams instead of one beam. 没有现有技术公开Nd:YAG激光在其1,064纳米基本波长处的用途。 No prior art discloses Nd: YAG laser at 1,064 nanometers use thereof at a fundamental wavelength.

下表比较了Dew、L-Esperance和Rochkind的技术与本发明。 The following table compares the Dew, L-Esperance and Rochkind art with the present invention.

</tables>尽管L′Esperance可以教导Rochkind的方法,但甚至没有现有技术暗示Nd:YAG激光可以以这种方式用很大的功率使用和获得所需的结果。 </ Tables> While L'Esperance teaches methods may Rochkind, but not even hint prior art Nd: YAG laser can use a lot of power and achieve the desired results in this manner.

优选实施方案的描述按照优选的方法,所述激光能是以100-800毫瓦输出功率水平和1.064纳米基本波长由Nd:YAG激光产生的。 Description of the Preferred Embodiments According to a preferred method, the laser energy is 100-800 mW output power level and the fundamental wavelength of 1.064 nanometers Nd: YAG laser produced. 将所述激光光能运用于身体的需要减少肌肉痉挛、增加循环、减少疼痛或者加快组织愈合的区域。 The laser energy applied to the body's need to reduce muscle spasm, increased circulation, decrease pain, regional or accelerate tissue healing. 界定表面区域,以所需量的时间和强度(具有限制在约1焦耳/cm2到约15焦耳/cm2范围的被照射组织能量密度)用激光光束照射组织表面以产生所需的治疗作用。 Defining the surface area, the amount of time and intensity (with a limit of about 1 joule / cm2 to about 15 joules / cm2 energy density of the irradiated tissue in the range) with the surface of the laser beam is irradiated tissue to produce the desired therapeutic effect. 治疗的强度和时间长短由待治疗的组织、所需侵入的深度、损伤的剧烈程度以及患者的状况确定。 The intensity and duration of treatment by the tissue to be treated, the desired depth, the extent of damage and severe invasive determination condition of the patient.

为了减少疼痛、减少发炎、并经刺激微循环加快组织愈合的目的,说明了一个低水平反应性激光系统的治疗处理方法,所有过程在不产生组织破坏性热作用的情况下成功地进行。 To reduce pain, reduce inflammation, and stimulated microcirculation accelerate tissue healing purposes, illustrates a method of therapeutic treatment of a low level reactive laser system, all the process does not produce successful in the case of tissue damaging thermal effects. 一个Nd:YAG激光共振器用作激光源。 A Nd: YAG laser used as the laser source resonator. 其基本波长是1,061纳米,并且具有100毫瓦-800毫瓦的可调光束能量输出。 Whose fundamental wavelength is 1,061 nm, and having an adjustable beam energy output of 100 mW -800 mW. 所述激光可以以脉冲或者连续方式进行操作,其输出由在0.1-9.9分钟范围内的暴露定时器控制。 The laser can be operated in a pulsed or continuous mode, which is controlled by the output exposure timer in the range of 0.1-9.9 minutes. 脉冲接通时间以0.1秒间隔时间在0.1-9.9秒的范围内可调。 Pulse on time of 0.1 sec adjustable time interval in the range of 0.1-9.9 seconds. 脉冲断开时间也以0.1秒间隔时间在0.1-9.9秒的范围内可调。 Pulse off time of 0.1 seconds is also adjustable time interval in the range of 0.1-9.9 seconds. Nd:YAG激光光束在1,064纳米的电磁光谱红外部分(因此是不可见的)进行操作。 Nd: YAG laser beam in the infrared portion of the electromagnetic spectrum 1,064 nm (therefore not visible) operated. 将光束传送到靶范围内的方法是采用柔软的石英纤维与聚焦的机头。 The method of transmitting the beam into the target range is the use of a flexible quartz fiber and focusing handpiece.

Nd:YAG激光光束脱离激光头的输出耦合器,并在通过循环可变的中等密度衰减器之前由一对排列的楔形物引导。 Nd: YAG laser beam from the output coupler of the laser head and through the loop before the variable attenuator medium density guided by a pair of alignment wedges. 穿过衰减器的光线通过一对在光学纤维电缆最接近的末端上的90毫米焦点长透镜聚焦。 Light passing through the attenuator is focused through a pair of 90 mm focal length lens on the end of the fiber optic cable is closest.

主要光束衰减器是放置在输出耦合器和光束引导镜之间的激光头外部的开闭器。 The main beam attenuator is placed outside the laser head between the output coupler mirror and the beam of light shutter. 其包括四个组件:90度反射棱柱、开闭器臂,开闭器安装支架和促进螺线管。 Which includes four components: a 90 degree reflecting prism, a shutter arm, a shutter mounting bracket and promote the solenoid. 棱柱安装到开闭器臂上,以便在通常关闭的位置上棱柱拦截激光光束,并将其向下反射到激光板中的光束堆存处(dump)。 A prism mounted to the shutter arm so as to intercept the laser beam in the prism normally closed position, and the reflected light beam downwardly into the dump (the dump) of the laser plate. 当输出通道被选择,并且脚踏板被压下时(其导致开闭器臂提高并使得光束提高),螺线管是有能量的。 When the output channel is selected and foot pedal is depressed (which causes the shutter arm so that the light beam and increase increase), the solenoid is energy. 当螺线管臂去能量时,开闭器下降到关闭的位置。 When the solenoid arm is de-energizing, the shutter drops into the closed position.

光能由一种连续的光源产生,优选的是由在电磁光谱的近红外区中的1,064纳米波长的激光产生。 Light generated by a continuous light source, is preferably generated by a laser wavelength of 1,064 nanometers in the near infrared region of the electromagnetic spectrum. 激光由指导光能光束到组织表面的光纤维导向装置和耦合器提供。 Guiding the laser light beam onto the optical fiber guide means and the tissue surface to provide coupling. 控制光辐射的能量,并用于产生在所照射的组织中的最小吸收率,该吸收率将所照射组织的平均温度提高到基础体温水平之上,但其不超过最大吸收率(其大得足以将所照射的组织转化成胶原物质)。 Controlling the light radiated energy, and for generating a minimum absorption rate in the irradiated tissue, the absorption rate will increase the average temperature of the irradiated tissue to a level above the basal body temperature, but which does not exceed the maximum absorption rate (which is large enough to the irradiated tissue is converted into collagen materials).

通过广泛的试验已确定,在100-800毫瓦功率输出的水平的1,064纳米的主要波长下,以在治疗位点上产生约1.0焦耳/cm2和15焦耳/cm2范围内的发射激光光束能量密度的聚焦的激光光束操作Nd:YAG激光时可满足上述条件。 It has been determined through extensive testing, the main wavelength of 1,064 nanometers at 100-800 mW of output power levels, to produce an energy density of the laser beam emitted range from about 1.0 Joules / cm2 and 15 J / cm2 range in the treatment site operation of the focused laser beam Nd: YAG can satisfy the above conditions laser.

当使用上述方法时,观察到了在组织中的和在细胞水平上的某些生理机制。 When the above method is observed in certain tissues and physiological mechanisms at the cellular level. 在微循环系统评价中,例如,血液脉管壁具有感光性已被证明。 In the evaluation of microcirculation system, e.g., blood vessel wall having photosensitivity has been demonstrated. 当血液脉管壁暴露于以上提出的激光辐射时,紧张在平滑肌细胞中受到抑制,这样,在毛细管中增加血流量。 When the blood vessel wall exposed to the laser radiation forth above, the tension in the smooth muscle cells is suppressed, so the increase in blood flow in the capillary. 已观察到的其它作用是:外周的毛细新血管形成、血液血小板聚集减弱、三价至单价形式的O2还原(由此使得组织有更大的氧合作用)、在血液中缓冲物质浓度降低、红细胞变形指数稳定、血液过氧化的脂氧化产物减少。 Other effects have been observed are: peripheral vascular new capillary formation, decreased blood platelet aggregation, a monovalent to trivalent form O2 reduction (thereby allowing greater tissue oxygenation), to reduce a buffer substance concentration in the blood, erythrocyte deformation index stability, reduce blood lipid peroxide oxidation products. 已观察到的其它作用是抗凝血酶活性指数增加、抗氧化剂系统酶(如超氧化物歧化酶和过氧化氢酶)的刺激作用。 Other action has been observed that the increased index of antithrombin activity, antioxidant enzyme systems (e.g., superoxide dismutase and catalase) stimulation. 观察到从所照射的区域的静脉和淋巴和流出物增加。 Increase was observed from the irradiated region and the venous and lymphatic effluent. 在上述区域中的组织渗透性实质上得到提高。 In the tissue permeability in the area is improved substantially. 这有助于在组织中立刻减少水肿和血肿浓缩物。 This helps to reduce swelling and hematoma immediately concentrate in the tissues. 在细胞水平上,也注意到线粒体产生增加量的ADP,尔后增加ATP产生。 At the cellular level, also noted mitochondria produce increased amounts of ADP, and later increased ATP production. 也似乎增加了组织膜上在细胞水平上的钙和钠泵的刺激作用。 Also it appears to increase the role of calcium and stimulate tissue membrane at the cellular level of the sodium pump.

在神经元水平上,观察到了作为前述治疗处理的结果的下列作用。 At the level of the neurons it was observed as a result of the therapeutic treatment of the following effects. 首先,存在压碎的和完整的神经的增加的作用潜力。 First, there is crushed and intact nerves to increase the role of potential. 在所照射的区域上血液供给和轴突数量增加。 Increased blood supply and the number of axons in the irradiated area. 当组织被治疗时,注意到伤疤组织的抑制作用。 When the treated tissue, scar tissue inhibition noted. 存在神经膜通透性的立即增加。 There is the nerve membrane permeability increased immediately. 已观察到通过神经的钙和钾离子通透性至少在120天长期变化。 It has been observed permeability of calcium and potassium ions through the nerve secular variation of at least 120 days. RNA和随后的DNA的生产增加。 Increase RNA and subsequent DNA production. 产生单价氧(其在细胞再生中是一个重要的因素)。 Generating monovalent oxygen (which is an important factor in cell regeneration). 具有神经损伤的病理退化改变成再生。 Pathological degeneration with nerve injury is changed to regeneration. 星形胶质细胞和少突神经胶质细胞受到刺激,造成外围神经轴突和髓磷脂的生产增加。 Astrocytes and oligodendrocytes cells are stimulated, resulting in peripheral nerve axons and myelin production increase.

血液的吞噬细胞裂解增加,进而实质上减少感染。 Phagocytic cells lysed blood increases, thereby substantially reducing the infection. 也显示出明显的抗炎症现象,其使得腱、神经、关节囊的炎症减少,同时产生加强的胶原。 Also showed significant anti-inflammatory phenomena which makes tendons, nerves reduced, the inflammation of the joint capsule, while generating enhanced collagen. 在有限的循环条件下在伤口闭合中也有对明显增加的粒状组织的影响。 Under limited cycling conditions have effect on the significant increase of granulation tissue in the wound closure.

已观察到组织的痛觉缺失与组织水平上的复杂的系列活动相联系。 It has been observed complex series of events on the level of analgesia and organizations linked to the organization. 在局部水平上,有炎症的减弱,引起渗出物的再吸收。 At the local level, there is reduced inflammation, causing a reabsorption of exudates. 脑啡肽和内啡肽得到补充,在脊髓水平上和人脑中调节疼痛的产生。 Enkephalins and endorphins replenished in the human brain and the spinal cord modulate the production of pain. serotnogenic途径也得到补充。 serotnogenic approach has also been supplemented. 虽然不是完全清楚,但人们相信组织的照射造成在细胞水平上的能量平衡的回复(这是疼痛减弱的原因)。 Although not entirely clear, but it is believed that irradiation organization and cause energy at the cellular level of the balance of reply (this is the cause of the pain diminished).

在另一种方法中,激光能是由1,055纳米的波长的Nd:YAG激光产生的。 In another method, the laser energy wavelength is 1,055 nm Nd: YAG laser produced. 其它激光可被使用或者被开发,以便以相同的功率水平在约1,000到约1,150纳米的优选的范围内进行操作。 Other laser may be used or developed to operate at the same power level preferably about 1,000 to about 1,150 nm range.

尽管参照优选的方法和参照特定的治疗用途描述了本发明,但以上的描述不是用来进行限制性意义上的解释的。 Although the method described with reference to a preferred of the present invention and with reference to specific therapeutic applications, the foregoing description is not intended to be interpreted in a restrictive sense. 对本领域技术人员而言,以上说明书的内容提示了所公开的实施方案的修改和本发明的其它应用。 To those skilled in the art, the content of the foregoing description suggests modifications and other applications of the present invention, the embodiment disclosed embodiment. 因此,应注意到,所附权利要求将覆盖落于本发明真正范围内的任何这样的修改或实施方案。 Thus, it should be noted that the appended claims will cover any such modifications or embodiments fall within the true scope of the invention.

Claims (20)

  1. 1.一种用于治疗活体生物组织小治疗区而不需将所说组织暴露在损伤性热作用下的方法,所说的方法包括:用一种低水平反应性激光产生连续的光能辐射,该辐射具有在电磁光谱近红外区范围内的波长,其输出功率在约100毫瓦到约800毫瓦的范围内,和将所说的连续的光能辐射聚焦在所说的小治疗区,以使在所照射的组织中吸收和转化成热的比率在足以使被辐射组织的平均温度提高到活体基础体温水平之上的最小比率与低于所照射的组织转化成胶原物质时的比率的最大比率之间的范围内,其中所说的光能辐射在所照射的组织位点上的密度在约1.0焦耳/cm2到约15焦耳/cm2的范围内。 1. A method for treating a small treatment area without living biological tissues under the method of said tissue to damaging thermal effects exposure, said method comprising: generating a continuous light radiation in a low level reactive laser the radiation having a wavelength in the near infrared region of the electromagnetic spectrum, the output power range of about 100 mW to about 800 mW, and the optical energy of said continuous focus the radiation treatment region of said small , so that the absorption and conversion to heat in the irradiated tissue in the ratio of the average temperature sufficient to increase the irradiated tissue to a minimum ratio above the ratio at the body temperature of the living body based conversion level less than with the irradiated tissue into collagens within a range between the maximum ratio, wherein said radiation energy density at the irradiated tissue site from about 1.0 Joules / cm2 to about 15 joules / cm2 of the range.
  2. 2.按照权利要求1的方法,其中所说的波长是约1,064纳米。 2. The method according to claim 1, wherein said wavelength is about 1,064 nanometers.
  3. 3.按照权利要求2的方法,其中所说的低水平反应性激光包括Nd:YAG激光。 3. The method according to claim 2, wherein said low level reactive laser comprises a Nd: YAG laser.
  4. 4.按照权利要求3的方法,其中在栅格中的许多小治疗区上用所说的连续的光能辐射以提供治疗效果所需量的时间和强度照射所说的组织。 The method according to claim 3, wherein the treatment zone over many small raster with said radiation to provide a continuous light intensity and irradiation time of said amount of tissue desired therapeutic effect.
  5. 5.按照权利要求3的方法,其中每一个小治疗区具有在约0.5mm2到约2mm2的范围内的区域。 The method according to claim 3, wherein each small treatment area has an area in the range of from about 0.5mm2 to about 2mm2 is.
  6. 6.按照权利要求3的方法,其中所说的低水平反应性激光用接通时间在0.1至9.9秒范围内,断开时间在0.1至9.9秒范围内的各脉冲来脉冲。 Low level reactive laser 6. The method according to claim 3, wherein said on-time used in the range of 0.1 to 9.9 seconds, OFF time of each pulse in the range of 0.1 to 9.9 seconds to pulse.
  7. 7.按照权利要求3的方法,其中以继续不断的方式操作所说的低水平反应性激光。 7. A method according to claim 3, wherein the continuing to operate in a manner of said low level reactive laser.
  8. 8.按照权利要求1的方法,其中所说的波长是约1,055纳米。 8. The method according to claim 1, wherein said wavelength is about 1,055 nanometers.
  9. 9.按照权利要求4的方法,其中所说的低水平反应性激光包括Nd:YLF激光。 9. The method according to claim 4, wherein said low level reactive laser comprises a Nd: YLF laser.
  10. 10.按照权利要求9的方法,其中在栅格中的许多小治疗区上用所说的连续的光能辐射以提供治疗效果所需量的时间和强度照射所说的组织。 10. A method of continuous light irradiation according to claim 9, wherein the treatment with many small regions in a grid to provide a therapeutic effect of said desired amount of time and intensity of illumination of said tissue.
  11. 11.按照权利要求9的方法,其中每一个小治疗区具有在约0.5mm2到约2mm2的范围内的区域。 11. The method according to claim 9, wherein each small treatment area has an area in the range of from about 0.5mm2 to about 2mm2 is.
  12. 12.按照权利要求9的方法,其中所说的低水平反应性激光用接通时间在0.1至9.9秒范围内,断开时间在0.1至9.9秒范围内的各脉冲来脉冲。 Low level reactive laser 12. A method according to claim 9, wherein said in the range of 0.1 to 9.9 seconds, OFF time of each pulse in the range of 0.1 to 9.9 seconds to the on-time pulses.
  13. 13.按照权利要求9的方法,其中以继续不断的方式操作所说的低水平反应性激光。 13. The method according to claim 9, wherein continuing to operate in a manner of said low level reactive laser.
  14. 14.按照权利要求1的方法,其中所说的低水平反应性激光包括Nd:YAG激光。 Low level reactive laser 14. The method according to claim 1, wherein said comprises Nd: YAG laser.
  15. 15.按照权利要求1的方法,其中所说的低水平反应性激光包括Nd:YLF激光。 15. The method according to claim 1, wherein said low level reactive laser comprises a Nd: YLF laser.
  16. 16.按照权利要求1的方法,其中在栅格中的许多小治疗区上用所说的连续的光能辐射以提供治疗效果所需量的时间和强度照射所说的组织。 16. The continuous light irradiation method according to claim 1, wherein the treatment with many small regions in a grid to provide a therapeutic effect of said desired amount of time and intensity of illumination of said tissue.
  17. 17.按照权利要求1的方法,其中每一个治疗点具有在约0.5mm2到约2mm2的范围内的区域。 17. The method according to claim 1, wherein each treatment point has an area in the range of from about 0.5mm2 to about 2mm2 is.
  18. 18.按照权利要求1的方法,其中所说的低水平反应性激光用接通时间在0.1至9.9秒范围内,断开时间在0.1至9.9秒范围内的各脉冲来脉冲。 Low level reactive laser 18. The method according to claim 1, wherein said on-time used in the range of 0.1 to 9.9 seconds, OFF time of each pulse in the range of 0.1 to 9.9 seconds to pulse.
  19. 19.按照权利要求1的方法,其中以继续不断的方式操作所说的低水平反应性激光。 19. The method according to claim 1, wherein continuing to operate in a manner of said low level reactive laser.
  20. 20.按照权利要求1的方法,其中所说的波长在约1,000纳米到约1,150纳米的范围内。 20. The method according to claim 1, wherein said wavelength is in the range from about 1,000 nanometers to about 1,150 nanometers.
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