CN117794509A - 育毛剂 - Google Patents
育毛剂 Download PDFInfo
- Publication number
- CN117794509A CN117794509A CN202280054887.5A CN202280054887A CN117794509A CN 117794509 A CN117794509 A CN 117794509A CN 202280054887 A CN202280054887 A CN 202280054887A CN 117794509 A CN117794509 A CN 117794509A
- Authority
- CN
- China
- Prior art keywords
- hair
- palmitoyl dipeptide
- acid
- phytosphingosine
- diaminobutyryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003779 hair growth Effects 0.000 title claims abstract description 55
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 99
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 94
- 210000004919 hair shaft Anatomy 0.000 claims abstract description 55
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 claims abstract description 53
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 claims abstract description 53
- 229940033329 phytosphingosine Drugs 0.000 claims abstract description 53
- 210000004209 hair Anatomy 0.000 claims abstract description 40
- 239000004480 active ingredient Substances 0.000 claims abstract description 32
- 230000012010 growth Effects 0.000 claims abstract description 19
- QJQNWKPSKDLCOX-UHFFFAOYSA-N 3,3-diamino-2-hydroxybutanoic acid Chemical compound NC(C(C(=O)O)O)(C)N QJQNWKPSKDLCOX-UHFFFAOYSA-N 0.000 claims abstract description 12
- 230000001737 promoting effect Effects 0.000 claims abstract description 11
- 210000004709 eyebrow Anatomy 0.000 claims abstract description 10
- 210000000720 eyelash Anatomy 0.000 claims abstract description 10
- 239000002253 acid Substances 0.000 claims description 31
- 230000001965 increasing effect Effects 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 14
- 238000002360 preparation method Methods 0.000 claims description 14
- JBNUARFQOCGDRK-GBXIJSLDSA-N 4-hydroxy-L-threonine Chemical compound [O-]C(=O)[C@@H]([NH3+])[C@H](O)CO JBNUARFQOCGDRK-GBXIJSLDSA-N 0.000 claims description 12
- -1 hydroxy threonic acid Chemical compound 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 5
- 230000001256 tonic effect Effects 0.000 claims description 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- 239000007952 growth promoter Substances 0.000 claims 2
- 239000004131 EU approved raising agent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 39
- 230000014509 gene expression Effects 0.000 abstract description 20
- 230000002500 effect on skin Effects 0.000 abstract description 18
- YPOTXRKSDBYOTN-FBCQKBJTSA-N (2s,3r)-2-[4,4-diaminobutanoyl(hydroxy)amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)N(O)C(=O)CCC(N)N YPOTXRKSDBYOTN-FBCQKBJTSA-N 0.000 abstract description 14
- 108090000623 proteins and genes Proteins 0.000 abstract description 4
- 210000004761 scalp Anatomy 0.000 description 37
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 23
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 23
- 210000004027 cell Anatomy 0.000 description 23
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 16
- 241000282414 Homo sapiens Species 0.000 description 13
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 13
- 230000031774 hair cycle Effects 0.000 description 9
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 8
- 229960005305 adenosine Drugs 0.000 description 8
- 230000004570 RNA-binding Effects 0.000 description 7
- 239000002537 cosmetic Substances 0.000 description 7
- 239000002299 complementary DNA Substances 0.000 description 6
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- 101150112014 Gapdh gene Proteins 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 108010016626 Dipeptides Proteins 0.000 description 3
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000003698 anagen phase Effects 0.000 description 3
- 230000003656 anti-hair-loss Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 230000003648 hair appearance Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 229960003632 minoxidil Drugs 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000003753 real-time PCR Methods 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 2
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 101000993347 Gallus gallus Ciliary neurotrophic factor Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 102000015696 Interleukins Human genes 0.000 description 2
- 108010063738 Interleukins Proteins 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000010804 cDNA synthesis Methods 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 150000004985 diamines Chemical class 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003780 hair follicle Anatomy 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 229940047122 interleukins Drugs 0.000 description 2
- 230000016507 interphase Effects 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000003797 telogen phase Effects 0.000 description 2
- 239000011534 wash buffer Substances 0.000 description 2
- YQGDEPYYFWUPGO-VKHMYHEASA-N (3s)-4-azaniumyl-3-hydroxybutanoate Chemical compound [NH3+]C[C@@H](O)CC([O-])=O YQGDEPYYFWUPGO-VKHMYHEASA-N 0.000 description 1
- 241001340526 Chrysoclista linneella Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 238000011529 RT qPCR Methods 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000003655 absorption accelerator Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 229960002298 aminohydroxybutyric acid Drugs 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 201000002996 androgenic alopecia Diseases 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000003778 catagen phase Effects 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 239000002734 clay mineral Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000003662 hair growth rate Effects 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 239000008266 hair spray Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000003752 improving hair Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
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- 239000002184 metal Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000003658 preventing hair loss Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000003813 thin hair Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 230000006711 vascular endothelial growth factor production Effects 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021-102087 | 2021-06-19 | ||
| JP2021102087 | 2021-06-19 | ||
| PCT/JP2022/024018 WO2022265052A1 (ja) | 2021-06-19 | 2022-06-15 | 育毛剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117794509A true CN117794509A (zh) | 2024-03-29 |
Family
ID=84527115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280054887.5A Pending CN117794509A (zh) | 2021-06-19 | 2022-06-15 | 育毛剂 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240285500A1 (https=) |
| JP (1) | JPWO2022265052A1 (https=) |
| KR (1) | KR20240023616A (https=) |
| CN (1) | CN117794509A (https=) |
| TW (1) | TW202317076A (https=) |
| WO (1) | WO2022265052A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240023618A (ko) * | 2021-06-19 | 2024-02-22 | 가부시키가이샤 아쥬반트 홀딩스 | 육모제 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139619A (en) | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| JPH06315021A (ja) | 1993-04-28 | 1994-11-08 | Sharp Corp | データ光通信装置 |
| JP3006345B2 (ja) | 1993-04-30 | 2000-02-07 | 住友電装株式会社 | フラット・ワイヤハーネスの長さ調節構造 |
| FR2744916B1 (fr) * | 1996-02-15 | 1998-04-10 | Oreal | Utilisation d'un 2-amino-alcane-1,3-diol en tant qu'agent destine a freiner la chute des cheveux et/ou induire et stimuler leur croissance |
| JP3220434B2 (ja) | 1998-12-28 | 2001-10-22 | 花王株式会社 | 化粧料 |
| FR2857597B1 (fr) * | 2003-07-18 | 2008-01-25 | Inst Europeen Biolog Cellulair | Utilisation de conjugues peptidiques pour la preparation de compositions destinees au traitement preventif et curatif de l'alopecie. |
| ES2397889B1 (es) * | 2011-03-25 | 2014-02-07 | Lipotec, S.A. | PÉPTIDOS MODULADORES DE PGC-1Alfa. |
| CN104994862A (zh) * | 2012-12-13 | 2015-10-21 | 普雷西恩护肤公司 | 增加真皮透明质酸浓度的局部制剂 |
| US9783562B2 (en) * | 2013-04-04 | 2017-10-10 | Phytos Co., Ltd | Phytosphingosine-1-phosphate derivative, preparation method therefor, and composition for preventing and treating hair loss or for growing hair comprising same |
| KR101800956B1 (ko) * | 2016-04-04 | 2018-01-25 | 주식회사 와이제이테크 | 파이토스핑고신과 효모추출물을 유효성분으로 포함하는 탈모방지 및 발모촉진용 조성물 |
| CN106075390A (zh) * | 2016-07-28 | 2016-11-09 | 广东药科大学 | 一种带正电荷的防脱复合柔性脂质体及其制备方法 |
| CN117695372A (zh) * | 2019-10-18 | 2024-03-15 | 安佳榜控股股份公司 | 头皮保养剂 |
| JP7291333B2 (ja) * | 2020-09-24 | 2023-06-15 | 株式会社アジュバンホールディングス | 育毛剤 |
| US20240099951A1 (en) * | 2020-11-19 | 2024-03-28 | Adjuvant Holdings Co., Ltd. | Hair growth stimulant |
-
2022
- 2022-06-15 WO PCT/JP2022/024018 patent/WO2022265052A1/ja not_active Ceased
- 2022-06-15 JP JP2023530384A patent/JPWO2022265052A1/ja active Pending
- 2022-06-15 US US18/571,529 patent/US20240285500A1/en active Pending
- 2022-06-15 KR KR1020247001997A patent/KR20240023616A/ko active Pending
- 2022-06-15 CN CN202280054887.5A patent/CN117794509A/zh active Pending
- 2022-06-17 TW TW111122674A patent/TW202317076A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20240285500A1 (en) | 2024-08-29 |
| WO2022265052A1 (ja) | 2022-12-22 |
| KR20240023616A (ko) | 2024-02-22 |
| JPWO2022265052A1 (https=) | 2022-12-22 |
| TW202317076A (zh) | 2023-05-01 |
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