CN117752735A - Traditional Chinese medicine composition for promoting absorption of subcapillary hematoma in early pregnancy and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for promoting absorption of subchorionic hematoma in early pregnancy, which comprises an oral medicine and an external patch, wherein the external patch is prepared by crushing the following raw materials and blending with vinegar: eucommia ulmoides, ramie root, fructus psoraleae, charred folium artemisiae argyi, semen cassiae, rheum officinale, betel nuts, fennel, akebia stem, pepper, clove, cinnamon and stir-fried bighead atractylodes rhizome; the oral medicine is prepared by crushing the following raw materials: semen Cuscutae, herba Taxilli, radix Dipsaci, colla Corii Asini, rhizoma anemarrhenae, cortex Phellodendri, rhizoma Dioscoreae, radix Paeoniae Rubra, radix Boehmeriae, eucommiae cortex, radix Saposhnikoviae, corni fructus, radix Angelicae sinensis, radix Rubiae and herba et Gemma Agrimoniae. The traditional Chinese medicine composition comprises an oral medicine and an external patch, has scientific and reasonable medicine compatibility, is combined with external application for oral administration, has obvious treatment effect on treating hematoma, and has the effects of stopping bleeding and preventing miscarriage, and has the effects of nourishing yin and blood heat, heat Fu Chong, yang and blood heat, and blood heat and bleeding.

Description

A traditional Chinese medicine composition that promotes the absorption of subchorionic hematoma in early pregnancy and its preparation method

Technical field

The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition that promotes the absorption of subchorionic hematoma in early pregnancy and a preparation method thereof.

Background technique

Subchorionic hematoma (SCH) refers to the separation and bleeding of the chorion and uterine decidua, causing blood to accumulate between the chorion and uterine decidua to form a hematoma. Mainly discovered through ultrasound, the incidence rate is 0.46% to 48%. Studies have shown that SCH can increase the risk of preeclampsia, small for gestational age, miscarriage, placental abruption and premature rupture of membranes. At present, there are few studies on the pathogenesis of SCH, and its underlying mechanism is still unclear. It may be related to abnormal placenta formation and implantation, abnormal autoimmune function, and coagulation dysfunction. Some scholars believe that during the invasion of the outer layer of fetal membranes into the decidua by the chorionic membrane in early pregnancy, due to maternal immune imbalance, the expression of protective cytokines is inhibited and damaging cytokines are overexpressed, resulting in abnormal coagulation function of the decidual blood vessels; at the same time, the outer layer of the villous membranes The syncytiotrophoblasts release a large amount of proteolytic enzymes, causing the decidua blood vessels to rupture, leading to bleeding between the decidua and the chorion, and eventually hemorrhage and fetal membrane peeling. Subchorionic hematoma is a common complication of early threatened abortion. Ultrasound shows the existence of crescent-shaped, triangular or irregular high-gray-scale, hypoechoic or anechoic areas between the gestational sac and the uterine wall. Subchorionic hematoma can occur at any stage of pregnancy. If the disease is intervened early, the prognosis is generally better.

At present, Western medicine mainly treats this disease by supplementing progesterone, luteal support, and hemostatic drugs. For patients with lower abdominal pain, tocolytic drugs (such as phloroglucinol) are added. For subchorionic hematoma that persists for a long time, antibiotics are added to fight infection. inflammation treatment. Traditional Chinese medicine doctor He Shaoshan often adds a small amount of traditional Chinese medicine to promote blood circulation and remove blood stasis in the treatment of pregnancy complicated by subchorionic hematoma, and has achieved good clinical results. Professor Luo Songping believes that the main pathogenesis of subchorionic hematoma during pregnancy is kidney deficiency and blood stasis. Therefore, when treating this disease, the basic treatment principles are to strengthen the kidneys, stabilize the fetus, remove blood stasis and stop bleeding, and to eliminate blood stasis and prevent fetus simultaneously, the effect is obvious. Professor Chu Yuxia believes that the main pathogenesis of subchorionic hematoma during pregnancy is spleen and kidney deficiency, yin deficiency, blood heat, and blood stasis. The main clinical treatment principles are to strengthen the spleen and kidneys, cool the blood and remove blood stasis, and Chu's An is commonly used. Add or subtract fetal prescriptions (Cuscutae, Dipsacus, Atractylodes, Chinese yam, Sanguisorba, Eclipta, donkey-hide gelatin, Scutellaria baicalensis, Amomum villosum, Salvia miltiorrhiza, Scutellaria baicalensis, Zhigancao). Feng Lina et al. treated 30 cases of subchorionic hematoma in pregnancy with the method of strengthening the kidney, relieving fetus, removing blood stasis and stopping bleeding, with an effective rate of 93.3%. Shao Rong et al. used dydrogesterone tablets, intramuscular injection of HCG needle, and oral administration of the Chinese medicine Xiangshen Baotai Decoction for pregnant women with uterine effusion after IVF-ET. The success rate of fetal preservation was 77.78%.

However, the above-mentioned treatment methods mostly use oral Chinese medicine prescriptions, and there are still few studies on the treatment of subchorionic hematoma in early pregnancy using oral Chinese medicine combined with external application.

Contents of the invention

The purpose of the present invention is to provide a traditional Chinese medicine composition that promotes the absorption of subchorionic hematoma in early pregnancy. The traditional Chinese medicine composition of the present invention includes oral medicine and an external patch. The medicine compatibility is scientific and reasonable, and the combination of oral administration and external application can effectively treat yin blood after pregnancy. Lower gathering to nourish the fetus, Yin and blood are deficient and blood heat is more abundant, heat is suppressed and the blood is hot, and Yang is excessive and blood heat, the blood will overflow when the blood is heated, forcing the blood to flow indiscriminately, forming hematoma, the therapeutic effect is remarkable, it has the effect of stopping bleeding and anti-fetal, and can be used externally Traditional Chinese medicine patches and oral medicines are highly effective, safe, convenient and widely used.

In order to achieve the above objects, the technical solutions adopted by the present invention are:

A traditional Chinese medicine composition that promotes the absorption of subchorionic hematoma in early pregnancy. The traditional Chinese medicine composition includes oral medicine and an external patch. The external patch is made by crushing the following raw materials and blending them with vinegar: Eucommia ulmoides, ramie root, and tonic. Bone fat, moxa leaf charcoal, cassia seeds, rhubarb, betel nut, cumin, akebia, peppercorns, cloves, cinnamon, fried atractylodes;

The oral medicine is made from the following raw materials after being crushed: Cuscuta semen, locust, Dipsacus bark, donkey-hide gelatin, Anemarrhena, Phellodendron, yam, red peony root, ramie root, Eucommia ulmoides, saposhnikovia, dogwood, angelica, madder, and agrimony.

Preferably, the external patch, in terms of mass ratio, Eucommia ulmoides: Ramie root: Psoralen: Mugwort charcoal: Cassia seed: Rhubarb: Areca nut: Cumin: Akebia: Zanthoxylum bungeanum: Clove: Cinnamon: Fried Atractylodes rhubarb is 30-60 :20-40:20-40:10-20:15-30:30-60:15-30:20-40:10-20:10-20:10-20:10-20:15-30.

Preferably, the external patch has a mass ratio of Eucommia ulmoides: Ramie root: Psoralen: mugwort charcoal: Cassia seed: Rhubarb: Areca nut: Cumin: Akebia: Zanthoxylum bungeanum: Clove: Cinnamon: Stir-fried Atractylodes macrocephala is 3:2. :2:1:1.5:3:1.5:2:1:1:1:1:1.5.

Preferably, the internal medicine, in terms of mass ratio, Cuscuta: Loranth: Dipsacus: Donkey-hide gelatin: Anemarrhena: Phellodendron: Chinese yam: Red peony: Ramie root: Eucommia: Windbreak: Dogwood: Angelica: Rubia: Agrimony is 20 -40：20-40：20-40：10-20：20-40：20-40：20-40：20-40：20-40：20-40：20-40：20-40：20-40 :20-40:30-60.

The present invention also claims a method for preparing the external patch for promoting the absorption of subchorionic hematoma in early pregnancy. Weigh various traditional Chinese medicines and beat them into powder, then add vinegar to mix them into a paste, and then apply the paste-like traditional Chinese medicine composition evenly. Cover it with gauze and then cover it with a layer of gauze.

The present invention also claims a method for preparing the oral medicine that promotes the absorption of subchorionic hematoma in early pregnancy. Each pharmaceutical raw material is weighed in proportion, washed, ground and crushed respectively, and 6 times the volume of all the ground and crushed medicines is added. Decoct in water twice, the first time for 2 hours and the second time for 1 hour. Combine the decoctions and filter the decoctions to obtain the oral medicine.

Preferably, the thickness of the paste-like traditional Chinese medicine composition is about 5 mm.

The present invention also protects the external patch produced by the production method for promoting the absorption of subchorionic hematoma in early pregnancy and the use method of the external patch.

Preferably, the method of use is to remove the upper layer of gauze from the external patch, and apply it on the abdomen from the upper part of the abdomen to the Shenque point, the lower part to the Guanyuan point, and a range of three inches from the midline of the umbilicus.

In the present invention, the properties and functions of the traditional Chinese medicine used are as follows:

Eucommia ulmoides: sweet and warm in nature, enters the liver and kidney meridian, can nourish the liver and kidneys, strengthen muscles and bones, and prevent miscarriage. It is a good product for treating fetal leakage or fetal movements. It has sedative, immunomodulatory, antioxidant, anti-fatigue, antiviral, antibacterial, neuroprotective and other effects, and has varying degrees of antibacterial effects on Staphylococcus aureus, Escherichia coli and Salmonella.

Cumin: pungent and warm in nature and flavor, and returns to the liver, kidney, spleen and stomach meridians. It has the effects of dispelling cold, relieving pain, regulating qi and regulating the stomach. Hot compress can relieve constipation and bloating, relieve abdominal pain and stop bleeding. It has certain effects on the human visceral system, central nervous system, cardiovascular system, endocrine system, immune system and chemical therapy, including regulating gastrointestinal function, analgesia, anti-inflammation, anti-hepatorenal toxicity, lowering blood lipids, lowering blood sugar, Antioxidant, antibacterial, antiviral, antitumor, regulating estrogen levels and other functional activities.

Zanthoxylum bungeanum: pungent in nature, warm and dry in nature, enters the spleen and stomach, can warm the body, relieve pain, and relieve itching. It has pharmacological effects such as analgesia, anti-inflammatory, skin absorption promotion, local anesthesia, antibacterial, antioxidant, and rheumatism dispelling.

Clove: pungent and warm in nature, has the effects of warming and reducing adverse effects, tonifying the kidneys and supporting yang, and has many functions such as antibacterial and anti-inflammatory, antipyretic and analgesic, antioxidant, anti-ulcer, anesthesia, promotion of transdermal absorption, and neuroprotection.

Cinnamon: Pungent and sweet in nature, it returns to the kidney and spleen meridian. It can induce fire, dissipate cold and relieve pain, replenish fire and help yang. It has antibacterial effects, anti-inflammatory, antioxidant, neuroprotective, hypoglycemic, lipid-lowering, uric acid-lowering and other pharmacological effects. It also has the functions of freshness preservation, deodorization and good fragrance retention.

Psoralen: bitter, pungent and warm in nature, it can warm the spleen and kidneys and solidify essence. Pharmacological research has proven that it has good anti-tumor, antioxidant, antibacterial, anti-inflammatory, anti-depressant, regulating estrogen levels, promoting bone growth, liver protection, vascular protection, neuroprotection and other effects.

Mugwort charcoal: warm in nature, can warm the menstruation and warm the uterus, stop bleeding and prevent pregnancy, has various pharmacological activities such as hemostasis, antifungal, antiviral, antitumor, antioxidant, etc. It is very useful in treating symptoms of threatened abortion, lower abdominal pain and vaginal bleeding. Good curative effect.

Akebia: bitter in taste, cold in nature, and directed to the heart, small intestine, and bladder meridians. It can clear away the heart, eliminate troubles, and diuretic. It has anti-inflammatory, antibacterial and diuretic effects.

Ramie root: sweet and cold in nature, cooling blood, stopping bleeding, and promoting miscarriage. Ramie root can treat miscarriage through immunity, coagulation, apoptosis, and nervous system regulation. It has good effects and is widely used in miscarriage.

Betel nut: Bitter and pungent in nature, it promotes qi, eliminates accumulation of water and promotes diuresis. Its main pharmacological effects include promoting gastrointestinal motility, anti-inflammatory and analgesic, antibacterial and bacteriostatic, anti-fatigue, anti-depressant, anti-aging, antioxidant, lowering blood sugar, regulating blood lipids, etc.

Cassia seed: sweet, bitter and salty, returns to the liver and large intestine meridian, can clear away heat, moisturize the intestines and relieve constipation. It contains a variety of chemical components and exhibits a variety of pharmacological activities, such as regulating gastrointestinal function, antibacterial, protecting the liver and improving eyesight, antibacterial, and antibacterial. Oxidation, blood pressure reduction, lipid regulation, etc.

Rhubarb: Bitter and cold in nature, it returns to the spleen, stomach and large intestine meridians. It can clear away heat and purge fire, cool blood and stop bleeding, remove blood stasis and stimulate menstruation. It can be used for those with blood stasis, heat, swelling, pain or bleeding, especially those with constipation or uncomfortable defecation. .

Cuscuta: sweet and warm, returns to the kidney, liver and spleen meridians. It has the effects of nourishing the liver and kidneys, fixing sperm and reducing urine, anti-fetal, improving eyesight and stopping diarrhea. It can nourish yang and yin, and is warm but not dry. , the characteristics of supplementing without stagnating.

Mistletoe: bitter and sweet in taste, neutral in nature; enters the liver and kidney meridians, has the effects of eliminating rheumatism, nourishing the liver and kidneys, strengthening the bones and muscles, and calming the fetus.

Dipsacus Dipsacus: nourishes the liver and kidneys, regenerates muscles and bones, and regulates blood vessels. It can be used to treat pain in the lower back, weakness in the feet and knees, fetal bleeding, metrorrhagia, vaginal discharge, spermatorrhea, bruises, sores, hemorrhoids, and carbuncles.

Donkey-hide gelatin: sweet in taste and neutral in nature. Returns to the lung, liver and kidney meridians. Nourishes blood, nourishes yin, moistens dryness, and stops bleeding. It is used for blood deficiency and chlorosis, dizziness and palpitations, muscle weakness, restlessness and insomnia, internal movement of wind due to deficiency, cough caused by dryness of the lungs, hemoptysis due to fatigue, hemoptysis, hematuria, hematochezia, and fetal leakage during pregnancy.

Anemarrhena: bitter, sweet, cold in nature. Returns to the lung, stomach and kidney meridians. Clear away heat, purge fire, promote body fluid and moisturize dryness. It is used for exogenous fever, high fever and polydipsia, lung-heat dryness and cough, bone-steaming hot flashes, internal heat to quench thirst, intestinal dryness and constipation.

Cortex Phellodendri: bitter in taste, cold in nature; returns to the kidney, bladder, and large intestine meridians, clears away heat and dampness, purges fire and detoxifies, removes bones and steams to clear away heat. Used for damp-heat diarrhea, jaundice, leucorrhea, hot stranguria, athlete's foot, impotence, bone steaming and labor fever, night sweats, spermatorrhea, sores, swollen poison, eczema and itching.

Yam: sweet in taste and neutral in nature; returns to the spleen, lung, and kidney meridians, replenishes qi and nourishes yin, nourishes the spleen, lungs and kidneys, consolidates essence and stops vaginal discharge.

Red peony root: bitter in taste, slightly cold in nature; returns to liver meridian, clears away heat and cools blood, activates blood circulation and removes blood stasis.

Fangfeng: pungent, sweet, slightly warm in nature, has the effects of dispelling wind and relieving superficial inflammation, relieving dampness and relieving pain, and relieving spasm.

Cornus officinalis: sour, astringent, slightly warm in nature; returns to the liver and kidney meridians, replenishes the liver and kidneys, astringes and solidifies astringency.

Angelica sinensis: warm in nature, sweet and pungent. Returns to the liver, heart and spleen meridians, nourishes and activates blood circulation, regulates menstruation and relieves pain, moistens the intestines and relieves constipation. It is used for blood deficiency and chlorosis, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, intestinal dryness and constipation, rheumatic arthralgia, injuries from falls, and carbuncle sores.

Madder: bitter in taste, cold in nature; returns to liver meridian, cools blood and removes blood stasis, stops bleeding and stimulates menstruation.

Agrimony: bitter, astringent, neutral in nature; returns to the heart and liver meridian, astringes and stops bleeding, stops dysentery, cuts malaria, and replenishes deficiency.

Compared with the prior art, the beneficial effects of the present invention are as follows:

(1) The external patch of the present invention takes a large amount of ramie root, takes the cold and cool properties of Akebia, and enters the Shaoyin heart meridian to reduce heart fire, clear away heat, stop bleeding, and prevent miscarriage; at the same time, it is combined with Eucommia ulmoides, psoralen, and moxa leaf charcoal to enter the Shaoyin kidney meridian. , nourish the liver and kidneys, warm the kidneys and help yang, increase the circulation of qi, blood and body fluids in the body, improve metabolism, and promote the absorption of hematomas while stopping bleeding; the above drugs are used together with cold and heat, so that both water and fire can be combined, to prevent miscarriage and stop bleeding, fennel, pepper, Cloves and cinnamon can increase the effect of warming the kidneys, and can also promote transdermal absorption and increase the utilization rate of drugs; betel nut, cassia seed, and rhubarb can promote qi and laxatives, promote gastrointestinal peristalsis, improve digestive tract function, reduce constipation, and make stool easier. Unobstructed, it can prevent the increase in abdominal pressure caused by constipation, thereby compressing the uterus and causing further bleeding; the combination of the above traditional Chinese medicines can stop bleeding and prevent miscarriage.

(2) The oral medicines of the present invention include donkey-hide gelatin, angelica root, and red peony root to nourish yin and nourish blood; madder and agrimony cool blood, stop bleeding, and prevent miscarriage; Cuscuta, mulberry, and Dipsacus have the functions of nourishing the liver and kidneys, strengthening the muscles and bones, strengthening the waist and knees, and strengthening the lungs. Ren, the effect of anti-abortion, their combined use will bring out the best effects; Anemarrhena and Phellodendron have the effect of clearing away heat and drying dampness, nourishing yin and reducing fire; Yam, Fangfeng, nourishing the spleen and stomach, promoting the production of body fluid and benefiting the lungs, and enhancing immunity; Dogwood It can nourish the liver and kidneys, astringe and stop bleeding; the above combination of traditional Chinese medicine can harmonize Chong and Ren, stop bleeding and relieve miscarriage.

(3) The present invention can treat hematomas caused by the accumulation of yin blood in the fetus after pregnancy, when the yin blood is deficient and the blood heat is more abundant, the heat is suppressed and the blood is hot, and when the yang is excessive and the blood is hot, the blood will overflow when the blood is hot, and the blood will be forced to move indiscriminately, resulting in hematoma. The effect is significant and not inferior to that of Western medicine.

(4) The traditional Chinese medicine composition of the present invention includes oral drugs and external patches. The drug compatibility is scientific and reasonable. It can be used internally and externally. It can nourish the fetus under the yin blood after pregnancy. When yin blood is deficient and blood heat is more abundant, the heat will rush away. , when Yang is excessive and the blood is hot, the blood will overflow when the blood is hot, forcing the blood to flow freely, resulting in the formation of hematoma. The treatment effect is remarkable, and it has the effect of stopping bleeding and relieving fetus, and the external Chinese medicine patch and oral medicine have significant curative effect, are safe and convenient, and are widely used.

Detailed ways

In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention are clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts should fall within the scope of protection of the present invention.

It should be noted that the terms "first", "second", etc. in the description and claims of the present invention are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It is to be understood that the data so used are interchangeable under appropriate circumstances so that the embodiments of the invention described herein are capable of being practiced in sequences other than those described herein. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, e.g., a process, method, system, product, or apparatus that encompasses a series of steps or units and need not be limited to those explicitly listed. Those steps or elements may instead include other steps or elements not expressly listed or inherent to the process, method, product or apparatus.

Example 1

A preparation method of a traditional Chinese medicine composition that promotes the absorption of subchorionic hematoma in early pregnancy. The preparation method of the external patch is: weigh 30 parts of Eucommia ulmoides, 20 parts of ramie root: 20 parts of psoralen: 10 parts of moxa leaf charcoal: 15 parts of cassia seeds: 30 parts of rhubarb: 15 parts of betel nut: 20 parts of cumin: 10 parts of Akebia: 10 parts of Sichuan peppercorns: 10 parts of cloves: 10 parts of cinnamon: 15 parts of stir-fried Atractylodes. Beat Chinese medicine into powder, then add vinegar to make a paste. , then apply the paste-like traditional Chinese medicine composition evenly on the gauze patch, and then cover it with a layer of gauze patch.

The preparation method of the medicine for oral administration is as follows: weigh 20 parts of dodder, 20 parts of locust, 20 parts of Dipsacus, 10 parts of donkey-hide gelatin, 20 parts of Anemarrhena, 20 parts of Cortex Phellodendron, 20 parts of Chinese yam, 20 parts of red peony root, and 20 parts of ramie root. 20 parts of Eucommia ulmoides, 20 parts of Fructus Fructus, 20 parts of Dogwood, 20 parts of Chinese Angelica, 20 parts of Rubia, and 30 parts of Agrimony. Wash, grind and crush them respectively. Add 6 times the volume of water to decoct all the grinded and crushed medicines. Two times, the first time is 2 hours, the second time is 1 hour, the decoctions are combined, and the decoctions are filtered to obtain the oral medicine.

Example 2

A preparation method of a traditional Chinese medicine composition that promotes the absorption of subchorionic hematoma in early pregnancy. The preparation method of the external patch is as follows: weigh 40 parts of Eucommia ulmoides, 30 parts of ramie root: 30 parts of psoralen: 15 parts of moxa leaf charcoal: 20 parts of cassia seeds: 45 parts of rhubarb: 20 parts of betel nut: 30 parts of fennel: 15 parts of Akebia: 15 parts of Sichuan peppercorns: 15 parts of cloves: 15 parts of cinnamon: 20 parts of fried Atractylodes. Beat Chinese medicine into powder, then add vinegar to make a paste. , then apply the paste-like traditional Chinese medicine composition evenly on the gauze patch, and then cover it with a layer of gauze patch.

The preparation method of the oral medicine is as follows: weigh 30 parts of dodder, 30 parts of locust, 30 parts of Dipsacus, 15 parts of donkey-hide gelatin, 30 parts of Anemarrhena, 30 parts of Cortex Phellodendron, 30 parts of Chinese yam, 30 parts of red peony root, and 30 parts of ramie root. 30 parts of Eucommia ulmoides, 30 parts of Fructus Fructus, 30 parts of Dogwood, 30 parts of Chinese Angelica, 30 parts of Rubia, and 45 parts of Agrimony. Wash, grind and crush them respectively. Add 6 times the volume of water to decoct all the grinded and crushed medicines. Two times, the first time is 2 hours, the second time is 1 hour, the decoctions are combined, and the decoctions are filtered to obtain the oral medicine.

Example 3

A preparation method of a traditional Chinese medicine composition that promotes the absorption of subchorionic hematoma in early pregnancy. The preparation method of the external patch is as follows: weigh 50 parts of Eucommia ulmoides, 35 parts of ramie root: 35 parts of psoralen: 15 parts of moxa leaf charcoal: 25 parts of cassia seeds: 50 parts of rhubarb: 25 parts of betel nut: 35 parts of cumin: 15 parts of Akebia: 15 parts of Sichuan peppercorns: 15 parts of cloves: 15 parts of cinnamon: 25 parts of fried Atractylodes. Beat Chinese medicine into powder, then add vinegar to make a paste. , then apply the paste-like traditional Chinese medicine composition evenly on the gauze patch, and then cover it with a layer of gauze patch.

The preparation method of the medicine for oral administration is as follows: weigh 35 parts of dodder, 35 parts of locust, 35 parts of Dipsacus, 15 parts of donkey-hide gelatin, 35 parts of Anemarrhena, 35 parts of Cortex Phellodendron, 35 parts of Chinese yam, 35 parts of red peony root and 35 parts of ramie root. 35 parts of Eucommia ulmoides, 35 parts of Fructus Fructus, 35 parts of Dogwood, 35 parts of Chinese Angelica, 35 parts of Rubia, and 50 parts of Agrimony. Wash, grind and crush them respectively. Add 6 times the volume of water to all the grinded and crushed medicines and boil them. Two times, the first time is 2 hours, the second time is 1 hour, the decoctions are combined, and the decoctions are filtered to obtain the oral medicine.

Example 4

A preparation method of a traditional Chinese medicine composition that promotes the absorption of subchorionic hematoma in early pregnancy. The preparation method of the external patch is: weigh 60 parts of Eucommia ulmoides, 60 parts of ramie root: 60 parts of psoralen: 20 parts of moxa leaf charcoal: 30 parts of cassia seeds: 60 parts of rhubarb: 30 parts of betel nut: 40 parts of cumin: 40 parts of Akebia: 40 parts of Sichuan peppercorns: 40 parts of cloves: 40 parts of cinnamon: 30 parts of fried Atractylodes. Beat Chinese medicine into powder, then add vinegar to mix into a paste. , then apply the paste-like traditional Chinese medicine composition evenly on the gauze patch, and then cover it with a layer of gauze patch.

The preparation method of the medicine for oral administration is as follows: weigh 40 parts of Cuscuta semen, 40 parts of Locust root, 40 parts of Dipsacus bark, 20 parts of donkey-hide gelatin, 40 parts of Anemarrhenae, 40 parts of Cortex Phellodendron, 40 parts of Chinese yam, 40 parts of red peony root, and 40 parts of ramie root. 40 parts of Eucommia ulmoides, 40 parts of Fructus Fructus, 40 parts of Dogwood, 40 parts of Chinese Angelica, 40 parts of Rubia, and 60 parts of Agrimony. Wash, grind and crush them respectively. Add 6 times the volume of water to all the grinded and crushed medicines and boil them. Two times, the first time is 2 hours, the second time is 1 hour, the decoctions are combined, and the decoctions are filtered to obtain the oral medicine.

Application examples

1. Case selection: Select patients who received miscarriage treatment in the Department of Traditional Chinese Medicine of Hubei Maternal and Child Health Hospital from May 2021 to November 2022, and observe 180 patients with early pregnancy threatened abortion combined with subchorionic hematoma, divided into three groups, respectively: There were 60 cases in each group A, B, and C. After statistical analysis, the general information of the three groups of patients in terms of age, average number of miscarriages, average number of miscarriages, and current gestational age was not statistically significant (all P>0.05), and the groups were comparable. See Table 1 for details.

Table 1 Comparison of the average age, average number of abortions, average abortions and current gestational weeks of pregnant patients

Comparison between the three groups P>0.05, there was no significant difference and no statistical significance. It indicates that the three groups are comparable.

2. Diagnostic criteria: (1) Diagnostic criteria for threatened abortion in early pregnancy: refer to "Obstetrics and Gynecology" and "Clinical Guidelines for New Traditional Chinese Medicines (Trial)": ① A small amount of vaginal bleeding occurs before the 12th week of pregnancy, without discharge of pregnancy products, and occurs one after another Lower abdominal pain or low back pain; ② Gynecological examination, the cervix is not dilated, and the size of the uterus is consistent with the number of weeks of menopause; ③ B-ultrasound examination, the size of the uterus, the gestational sac, embryo or fetus are consistent with the gestational age. (2) Diagnostic criteria for subchorionic hematoma: Refer to the "Ultrasound Atlas of Obstetrics and Gynecology". The B-ultrasound image shows an echoless area between the uterine wall and the gestational sac in the uterine cavity. The shape is mostly crescent, triangle or polygon. .

(1) Inclusion criteria: ① Meet the diagnostic criteria for threatened abortion in early pregnancy; ② Subchorionic hematoma on B-ultrasound examination; ③ Aged 20 to 40 years old; ④ Voluntarily accept the treatment of this trial, no major diseases of heart, liver, kidney and other organs, spouse Good health (especially no organic disease in the reproductive system); ⑤ Sign the informed consent form.

(2) Exclusion criteria ① Those with ≥ 3 consecutive spontaneous abortions; ② Those infected with rubella, cytomegalovirus, Toxoplasma gondii, and herpes simplex virus; ③ Those with severe anemia, heart failure, chronic nephritis, hypertension, diabetes, and systemic infection Such as those with high fever; ④ those with uterine malformation, uterine fibroids, adenomyosis; 5) those with untreated uterine adhesions, uterine effusion, endometrial polyps, endometrial hyperplasia, etc.; 6) those with mental illness; 7 unable to Those who insist on following the course of treatment.

3. Treatment methods:

Group A: Tocolytic treatment was started from the time of diagnosis, traditional tocolytic treatment, using progesterone injection (National Drug Approval No. H33020828, Zhejiang Xianju Pharmaceutical Co., Ltd., 20 mg/tube, adjusted according to the condition 20 to 60 mg, once a day )+dydrogesterone tablets (registration number H20170221, Abbott Healthcare Products B.V, Netherlands, 10 mg/tablet, adjusted according to the condition, 1 tablet orally each time, 3 times a day) until the subchorionic hematoma disappears.

Group B: The patient takes a supine or sitting position, removes the upper gauze patch of the external patch produced in Example 1, and applies it on the abdomen from the Shenque point to the Guanyuan point, and three inches from the midline of the umbilicus. , twice a day, 5 days as a course of treatment, 5 courses of treatment.

Group C: The external patch in Example 1 is used in combination with oral drugs. The patient takes a supine or sitting position, removes the upper gauze patch of the external patch, and applies it on the abdomen to Shenque point and down to Guanyuan acupoint, within three inches of the midline of the umbilicus, twice a day, 5 days as a course of treatment, and 5 courses of treatment; at the same time, oral medicine, 1 dose 1 day, taken twice a day in the morning and evening, 5 days as a course of treatment, 5 courses of treatment.

4. Efficacy evaluation: (1) Color ultrasound examination: The ultrasound instrument used is GE Voluson 730 three-dimensional color Doppler ultrasound instrument with an abdominal probe frequency of 3.5MHz. It is operated by a specialized doctor before treatment, 10 days after treatment, 18 days after treatment, and Transvaginal color Doppler ultrasound was used to measure the patient's bilateral uterine arteries, subchorionic hematoma area and gestational sac area on the 25th day. (2) Use SPSS22.0 statistical software for data analysis. First, test for normality and homogeneity of variances. Measurement data that conform to normal distribution are expressed as mean ± standard deviation (x-±s). Comparisons between three groups are done using two-dimensional tests. t-test for independent samples, paired-sample t-test for comparison before and after treatment within the group, and non-parametric rank-sum test for non-normal distribution; rank-sum test for clinical efficacy was used for comparison of clinical efficacy, and X-test was used for comparison of count data, with P<0.05 considered The difference was statistically significant.

5. Treatment results:

Table 2 Comparison of subchorionic hematoma area in three groups of patients before treatment and after 10, 18 and 25 days of treatment

Table 3 Comparison of pregnancy outcomes among 3 groups of patients

Group n abortion premature birth term birth Abortion gestational age gestational age Group A 60 11 10 39 9.7±2.3 37.3±1.1 Group B 60 8 3 49 10.2±2.1 38.3±1.7 Group C 60 6 2 52 10.6±2.0 38.7±1.3

It can be seen from the above evaluation results that the Chinese medicine composition prepared by the present invention for promoting the absorption of subchorionic hematoma in early pregnancy has better effects than Western medicine treatment, and the curative effect is significant, and the external Chinese medicine patch is more effective when used together with oral medicine. It is safe and convenient and has greater comprehensive significance for miscarriage treatment.

The above are only preferred specific embodiments of the present invention, and the protection scope of the present invention is not limited thereto. Any person familiar with the technical field can obviously obtain the simple technical solutions within the technical scope disclosed in the present invention. Changes or equivalent substitutions fall within the protection scope of the present invention.

Claims (7)

1. The traditional Chinese medicine composition for promoting the absorption of the subcapillary hematoma of early pregnancy is characterized by comprising an oral medicine and an external patch, wherein the external patch is prepared by crushing the following raw materials and blending with vinegar: eucommia ulmoides, ramie root, fructus psoraleae, charred folium artemisiae argyi, semen cassiae, rheum officinale, betel nuts, fennel, akebia stem, pepper, clove, cinnamon and stir-fried bighead atractylodes rhizome;

the oral medicine is prepared by crushing the following raw materials: semen Cuscutae, herba Taxilli, radix Dipsaci, colla Corii Asini, rhizoma anemarrhenae, cortex Phellodendri, rhizoma Dioscoreae, radix Paeoniae Rubra, radix Boehmeriae, eucommiae cortex, radix Saposhnikoviae, corni fructus, radix Angelicae sinensis, radix Rubiae and herba et Gemma Agrimoniae.

2. The traditional Chinese medicine composition according to claim 1, wherein the patch for external use comprises eucommia ulmoides in terms of mass ratio: radix Boehmeriae: fructus psoraleae: mugwort leaf charcoal: semen cassiae: rhubarb: betel nut: fennel: akebia stem: pricklyash peel: clove: cinnamon: the fried bighead atractylodes rhizome is 30-60:20-40:20-40:10-20:15-30:30-60:15-30:20-40:10-20:10-20:10-20:10-20:15-30.

3. The traditional Chinese medicine composition according to claim 1, wherein the oral medicine comprises, by mass, semen cuscutae: loranthus mulberry mistletoe: teasel root: donkey-hide gelatin: rhizoma anemarrhenae: cortex Phellodendri: chinese yam: radix paeoniae rubra: radix Boehmeriae: eucommia ulmoides: wind prevention: fructus Corni: chinese angelica root: radix Rubiae: 20-40% of hairyvein agrimony: 20-40:20-40:10-20:20-40:20-40:20-40:20-40:20-40:20-40:20-40:20-40:20-40:20-40:30-60.

4. The method for preparing the patch according to claim 1, wherein the preparation method comprises weighing each Chinese medicinal material, pulverizing into powder, adding vinegar, concocting into paste, uniformly coating the paste on gauze patch, and covering with a layer of gauze patch.

5. The Chinese medicinal composition according to claim 1, wherein the preparation method of the oral medicament is characterized in that raw materials of the oral medicament are weighed according to a proportion, respectively washed, ground and crushed, all the ground and crushed medicaments are added with water with a volume of 6 times for decoction twice, the first time is 2 hours, the second time is 1 hour, the decoctions are combined, and the decoction is filtered, so that the oral medicament is obtained.

6. The composition of claim 4, wherein the paste of the composition is applied to a thickness of about 5mm.

7. The composition of claim 4, wherein the patch is applied by removing the upper gauze layer of the patch and applying it to the abdomen to the Shenque acupoint, down to the Guanyuan acupoint, and three inches laterally to the umbilicus midline.