CN117624955A - Wrist pulse taking isolation film - Google Patents

Wrist pulse taking isolation film Download PDF

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Publication number
CN117624955A
CN117624955A CN202311716949.7A CN202311716949A CN117624955A CN 117624955 A CN117624955 A CN 117624955A CN 202311716949 A CN202311716949 A CN 202311716949A CN 117624955 A CN117624955 A CN 117624955A
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CN
China
Prior art keywords
membrane
graphene
wrist
long
nano
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Pending
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CN202311716949.7A
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Chinese (zh)
Inventor
张学海
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Tonghua High End High Tech Ltd By Share Ltd
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Tonghua High End High Tech Ltd By Share Ltd
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Priority to CN202311716949.7A priority Critical patent/CN117624955A/en
Publication of CN117624955A publication Critical patent/CN117624955A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/14Paints containing biocides, e.g. fungicides, insecticides or pesticides
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D7/00Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
    • C09D7/40Additives
    • C09D7/60Additives non-macromolecular
    • C09D7/61Additives non-macromolecular inorganic
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D7/00Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
    • C09D7/40Additives
    • C09D7/60Additives non-macromolecular
    • C09D7/63Additives non-macromolecular organic

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

本发明涉及一种腕部取脉隔离膜,单层的膜片,其厚度在0.01到2毫米之间,增强隔离膜覆盖在人体腕部桡动脉波动处;膜片的形状为长方形或原型或椭圆形;膜基材一包括塑料、纸张、化学纤维材料、棉织品、化学成膜材料、金属材料、非金属材料中任意一种或任意几种的混合物,膜片由膜基材一制备而成;膜基材二包括石墨烯、纳米除菌材料或银离子、长效灭菌剂、甘油、柔顺剂至少一种或几种混合物,石墨烯、纳米除菌材料或银离子、长效灭菌剂、甘油、柔顺剂中任何一种材料不低于1%‑5%,总合计重量份不超过5%‑25%。本发明腕部取脉隔离膜,通过局部喷涂或涂抹在手腕部形成保护膜,来组织手腕部皮肤与仪器的直接接触。

The invention relates to a wrist pulse-taking isolation membrane. It is a single-layer membrane with a thickness between 0.01 and 2 mm. The reinforced isolation membrane covers the radial artery fluctuations in the human wrist; the shape of the membrane is rectangular or prototype or Oval; the membrane base material includes any one or a mixture of any of plastics, paper, chemical fiber materials, cotton fabrics, chemical film-forming materials, metal materials, and non-metallic materials, and the diaphragm is prepared from the membrane base material ; The second membrane substrate includes graphene, nanometer sterilization materials or silver ions, long-term sterilizer, glycerin, and softener. At least one or several mixtures of graphene, nanometer sterilization materials or silver ions, long-term sterilization Any material among agent, glycerin and softener shall not be less than 1%-5%, and the total weight shall not exceed 5%-25%. The wrist pulse-taking isolation film of the present invention forms a protective film by local spraying or application on the wrist to prevent direct contact between the wrist skin and the instrument.

Description

Wrist pulse taking isolation film
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a wrist pulse taking isolation membrane.
Background
In traditional Chinese medicine pulse taking (pulse feeling, pulse taking and pulse taking), doctors directly take fingers on radial arteries of wrist parts of patients, and pulse condition information of testees is obtained through lifting, pressing and inspection. The physical condition of the subject is unknown (whether there is pathogen carrying) which can lead to possible cross-infection of the doctor. The doctor gives the pulse to the second subject, the doctor does not disinfect the hand, so that the probability of possible cross infection is extremely high, and similar events occur in reality.
The sensor of the traditional Chinese medicine pulse-taking device, which is in contact with the skin, is similar to the finger of a doctor, cannot be disinfected (the instrument sensitivity is strong, the disinfection opportunity affects the quality), and the problems are also caused when the wrist sphygmomanometer is used for measuring the blood pressure.
The present invention has been made in order to solve this problem.
Disclosure of Invention
The invention aims to provide a wrist vein access isolation membrane.
The aim of the invention is achieved by the following technical scheme:
a pulse taking isolating membrane for wrist features that its single-layer membrane has a thickness of 0.01-2 mm and the reinforcing isolating membrane is used to cover the radial artery of wrist.
Preferably, the membrane is rectangular or prototype or oval in shape.
Preferably, the first film substrate comprises any one or a mixture of any several of plastics, paper, chemical fiber materials, cotton fabrics, chemical film forming materials, metal materials and nonmetallic materials, and the film sheet is prepared from the first film substrate.
Preferably, the film substrate II comprises at least one or a mixture of more than one of graphene, nano sterilizing material or silver ion, long-acting sterilizing agent, glycerin and softener, wherein the total weight of any one of the graphene, nano sterilizing material or silver ion, long-acting sterilizing agent, glycerin and softener is not less than 1% -5%.
Preferably, the membrane is a membrane finished product A formed by a membrane substrate I and a membrane substrate II, wherein the membrane substrate II is graphene, and the membrane finished product A comprises the following components in parts by weight: graphene=1:0.01.
Preferably, the second film substrate is graphene and nano sterilization material, and the film finished product A comprises the following components in parts by weight: graphene: nano-degerming material = 1:0.01:0.05.
preferably, the second film substrate is graphene, a nano sterilization material and a long-acting sterilizing agent, and the film product A comprises the following components in parts by weight: graphene: nano sterilizing material: long-acting sterilant = 1:0.01:0.05:0.1.
preferably, the film substrate II is graphene, a nano sterilization material, a long-acting sterilizing agent and glycerin, and the film product A comprises the following components in parts by weight: graphene: nano sterilizing material: long-acting sterilizing agent: glycerol = 1:0.01:0.05:0.1:0.1.
preferably, the second film substrate is graphene, a nano sterilization material, a long-acting sterilizing agent, glycerol and a softener, and the film product A comprises the following components in parts by weight: graphene: nano sterilizing material: long-acting sterilizing agent: glycerol: softener = 1:0.01:0.05:0.1:0.1:0.1.
preferably, the membrane is three or more layers, and related functional materials are added between the middle layers, wherein the functional materials comprise bactericides, fragrances, plasticizers and luminescent agents.
The beneficial technical effects are as follows:
the wrist vein isolation membrane is formed by spraying or smearing the wrist part locally to form a protective film, so that the skin of the wrist part is organized to be in direct contact with an instrument.
Drawings
The invention is further described below with reference to the accompanying drawings.
FIG. 1 is a schematic diagram of a wrist vein access isolation membrane structure of the present invention;
FIG. 2 is a schematic view of a wrist vein access isolation membrane according to another embodiment of the present invention.
Detailed description of the preferred embodiments
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
Referring to fig. 1, a wrist vein isolation membrane is a single-layer membrane 1, the thickness of the membrane is between 0.01 and 2 millimeters, and the reinforced isolation membrane covers the radial artery fluctuation of the wrist of a human body, so that a doctor's finger and the skin of a subject form an isolation layer to block cross infection.
The membrane 1 is rectangular or prototype or oval or other shape.
The first film substrate comprises any one or a mixture of any of plastics, paper, chemical fiber materials, cotton fabrics, chemical film forming materials, metal materials and nonmetallic materials.
The membrane 1 is prepared from a membrane substrate I.
The film substrate II comprises at least one or a mixture of graphene, nano sterilizing material or silver ions, a long-acting sterilizing agent, glycerin and a softener.
The total weight of any one material of the graphene, the nano sterilizing material or the silver ion, the long-acting sterilizing agent, the glycerol and the softener is not less than 1% -5%, and the total weight is not more than 5% -25%.
The membrane 1 is a membrane finished product A composed of a membrane substrate I and a membrane substrate II.
The film substrate II is graphene, and the film finished product A comprises the following components in parts by weight: graphene=1:0.01.
The film substrate II is graphene and nano sterilization material, and the film finished product A comprises the following components in parts by weight: graphene: nano-degerming material = 1:0.01:0.05.
the second film substrate is graphene, a nano sterilization material and a long-acting sterilizing agent, and the film product A comprises the following components in parts by weight: graphene: nano sterilizing material: long-acting sterilant = 1:0.01:0.05:0.1.
the second film substrate is graphene, a nano sterilization material, a long-acting sterilizing agent and glycerin, and the film product A comprises the following components in parts by weight: graphene: nano sterilizing material: long-acting sterilizing agent: glycerol = 1:0.01:0.05:0.1:0.1.
the film substrate II is graphene, a nano sterilization material, a long-acting sterilizing agent, glycerol and a softener, and the film product A comprises the following components in parts by weight: graphene: nano sterilizing material: long-acting sterilizing agent: glycerol: softener = 1:0.01:0.05:0.1:0.1:0.1.
the using method comprises the following steps: the membrane 1 is placed locally or wrapped around the wrist.
Referring to fig. 2, the membrane 1 has three or more layers, and the middle layer 2 is filled with related functional materials including bactericide, aromatic, plasticizer, luminescent agent, etc.
Example 2
A preparation method of a wrist vein isolation membrane comprises the steps of preparing a membrane substrate I and a membrane substrate II into a suspending emulsion mixed solvent by a micro powder process, wherein the suspending emulsion mixed solvent exists in a liquid state to form a membrane finished product B, the membrane substrate II is graphene, and the membrane finished product B comprises the following components in parts by weight: graphene=1:0.01.
The film substrate II is graphene and nano sterilization material, and the film finished product B comprises the following components in parts by weight: graphene: nano-degerming material = 1:0.01:0.05.
the second film substrate is graphene, a nano sterilization material and a long-acting sterilizing agent, and the film finished product B comprises the following components in parts by weight: graphene: nano sterilizing material: long-acting sterilant = 1:0.01:0.05:0.1.
the film substrate II is graphene, a nano sterilization material, a long-acting sterilizing agent and glycerol, and the film product B comprises the following components in parts by weight: graphene: nano sterilizing material: long-acting sterilizing agent: glycerol = 1:0.01:0.05:0.1:0.1.
the film substrate II is graphene, a nano sterilization material, a long-acting sterilizing agent, glycerol and a softener, and the film product B comprises the following components in parts by weight: graphene: nano sterilizing material: long-acting sterilizing agent: glycerol: softener = 1:0.01:0.05:0.1:0.1:0.1.
the solvent amount of the solvent is a specific column controlled to be film-formed within 3 minutes.
The using method comprises the following steps: the protective film is formed by spraying or smearing the wrist part locally.
While the fundamental and principal features of the invention and advantages of the invention have been shown and described, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.

Claims (10)

1. The wrist pulse taking isolation membrane is characterized by comprising a single-layer membrane (1) with the thickness of 0.01-2 mm, and the enhanced isolation membrane is covered on the radial artery fluctuation of the wrist of a human body.
2. The wrist vein access isolation membrane according to claim 1, characterized in that the shape of the membrane (1) is rectangular or prototype or oval.
3. The wrist vein access isolation membrane according to claim 1, wherein the membrane substrate one comprises any one or a mixture of any several of plastics, paper, chemical fiber materials, cotton fabrics, chemical film forming materials, metal materials and nonmetal materials, and the membrane (1) is prepared from the membrane substrate one.
4. The wrist vein access isolation membrane according to claim 1, wherein the membrane substrate II comprises at least one or a mixture of more than one of graphene, nano sterilizing material or silver ion, long-acting sterilizing agent, glycerin and softener, wherein the total weight of any one of the graphene, nano sterilizing material or silver ion, long-acting sterilizing agent, glycerin and softener is not less than 1% -5%, and the total weight is not more than 5% -25%.
5. The wrist vein access isolation membrane according to claim 4, wherein the membrane 1 is a membrane finished product A composed of a membrane substrate I and a membrane substrate II, the membrane substrate II is graphene, and the membrane finished product A comprises the following components in parts by weight: graphene=1:0.01.
6. The wrist vein access isolation membrane according to claim 4, wherein the membrane base material II is graphene and nano sterilization materials, and the membrane product A comprises the following components in parts by weight: graphene: nano-degerming material = 1:0.01:0.05.
7. the wrist vein access isolation membrane according to claim 4, wherein the membrane base material II is graphene, a nano sterilization material and a long-acting sterilizing agent, and the weight parts of a membrane finished product A are as follows: graphene: nano sterilizing material: long-acting sterilant = 1:0.01:0.05:0.1.
8. the wrist vein access isolation membrane according to claim 4, wherein the membrane base material II is graphene, nano sterilization material, long-acting sterilizing agent and glycerin, and the membrane product A comprises the following components in parts by weight: graphene: nano sterilizing material: long-acting sterilizing agent: glycerol = 1:0.01:0.05:0.1:0.1.
9. the wrist vein access isolation membrane according to claim 4, wherein the membrane base material II is graphene, nano sterilization material, long-acting sterilizing agent, glycerol and softener, and the membrane product A comprises the following components in parts by weight: graphene: nano sterilizing material: long-acting sterilizing agent: glycerol: softener = 1:0.01:0.05:0.1:0.1:0.1.
10. the wrist vein access isolation membrane according to claim 4, wherein the membrane (1) is three or more layers, and related functional materials are added between the middle layers, wherein the functional materials comprise bactericides, fragrances, plasticizers and luminescent agents.
CN202311716949.7A 2023-12-14 2023-12-14 Wrist pulse taking isolation film Pending CN117624955A (en)

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Application Number Priority Date Filing Date Title
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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1827179A (en) * 2005-03-04 2006-09-06 蒋婧 Post-surgery functional barrier film and method for preparing the same
CN204181787U (en) * 2014-09-11 2015-03-04 天津法莫西医药科技有限公司 A kind of novel wrist medical dressing
CN106264472A (en) * 2016-09-28 2017-01-04 中国科学院重庆绿色智能技术研究院 A kind of pulse-taking instrument based on Graphene pliable pressure sensor
CN108078959A (en) * 2016-11-22 2018-05-29 北京赛特瑞科技发展有限公司 A kind of antibacterial and protective film and its preparation method and application
CN108606980A (en) * 2018-08-01 2018-10-02 太仓斯迪克新材料科技有限公司 A kind of high-molecular anti-bacteria liquid film and preparation method thereof
US20190006056A1 (en) * 2017-06-29 2019-01-03 Makalot Industrial Co., Ltd. Sensing material and unit for sensing physiological parameter and method for producing sensing material unit
CN111227808A (en) * 2020-03-25 2020-06-05 贵州中医药大学 A kind of palpation spray film finger cuff, preparation method and device
CN111690307A (en) * 2020-06-09 2020-09-22 浙江创冠医疗科技有限公司 Spraying type invisible breathable coating film and gloves with waterproof, antibacterial and antiviral functions, base material and glove preparation method and cleaning method

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1827179A (en) * 2005-03-04 2006-09-06 蒋婧 Post-surgery functional barrier film and method for preparing the same
CN204181787U (en) * 2014-09-11 2015-03-04 天津法莫西医药科技有限公司 A kind of novel wrist medical dressing
CN106264472A (en) * 2016-09-28 2017-01-04 中国科学院重庆绿色智能技术研究院 A kind of pulse-taking instrument based on Graphene pliable pressure sensor
CN108078959A (en) * 2016-11-22 2018-05-29 北京赛特瑞科技发展有限公司 A kind of antibacterial and protective film and its preparation method and application
US20190006056A1 (en) * 2017-06-29 2019-01-03 Makalot Industrial Co., Ltd. Sensing material and unit for sensing physiological parameter and method for producing sensing material unit
CN108606980A (en) * 2018-08-01 2018-10-02 太仓斯迪克新材料科技有限公司 A kind of high-molecular anti-bacteria liquid film and preparation method thereof
CN111227808A (en) * 2020-03-25 2020-06-05 贵州中医药大学 A kind of palpation spray film finger cuff, preparation method and device
CN111690307A (en) * 2020-06-09 2020-09-22 浙江创冠医疗科技有限公司 Spraying type invisible breathable coating film and gloves with waterproof, antibacterial and antiviral functions, base material and glove preparation method and cleaning method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
秦益民: "《含银功能性医用敷料》", vol. 1, 31 January 2022, 中国纺织出版社, pages: 70 - 71 *

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