CN117442697A - Traditional Chinese medicine composition for treating chronic obstructive pulmonary disease and preparation method and application thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease, which is composed of Cistanche deserticola, Morinda officinalis, Achyranthes bidentata, Eucommia ulmoides, Poria cocos, ginseng, Gecko, Scutellaria baicalensis, Trichosanthes melon, Salvia miltiorrhiza, Angelica sinensis, Curcuma turmeric, Dannanxing, Pinellia ternata. , almond, costus, citrus aurantium, tangerine peel, rehmannia glutinosa, Alisma and plantain. It can warm and nourish the spleen, kidney and lung yang, clear lung heat, activate blood circulation and remove blood stasis, dispel wind and phlegm, regulate qi, purge turbidity and diuresis. The invention also discloses its preparation method and application for the treatment of chronic obstructive pulmonary disease of spleen and kidney yang deficiency type.

Description

A traditional Chinese medicine composition for treating chronic obstructive pulmonary disease and its preparation method and application

Technical field

The invention belongs to the technical field of traditional Chinese medicine compositions and preparations, and specifically relates to a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease and its preparation method and application.

Background technique

Chronic obstructive pulmonary disease (COPD) is a group of lung diseases characterized by airflow limitation. The airflow limitation is not completely reversible and develops progressively, but it can be prevented and treated. The concept of "airflow limitation" is used in the definition of COPD instead of the old name "airway obstruction" because in simple emphysema, there is no organic obstructive disease in the airway, but due to The elasticity of the alveolar tissue decreases, thus lowering the alveolar pressure, making the air flow slow and blocked. Especially elderly men who smoke, most of them suffer from this disease, which is manifested by cough, sputum, difficulty breathing, etc. COPD mainly affects the lungs, but can also cause damage to various organs outside the lungs. Traditional Chinese medicine names it "lung distension". Traditional Chinese medicine believes that chronic obstructive pulmonary disease is generally divided into cold drinks shooting into the lungs, phlegm and heat blocking the lungs, lung and kidney deficiency, spleen and kidney yang deficiency, cold phlegm in the lungs, hot phlegm in the lungs, due to cough, Asthma and other syndromes will not heal over time. After the onset, the condition is difficult to treat and difficult to recover. Among them, spleen and kidney yang deficiency is the most common. Symptoms include chest tightness and suffocation, exhaling more and inhaling less, wheezing when moving, spontaneous cold sweats, lukewarm limbs, and fear. Cold and timid, long and clear urine or incontinence, pale tongue, tender and fat tongue, and thin pulse.

CN110292601B discloses a traditional Chinese medicine compound made of the following traditional Chinese medicines as raw materials: tangerine peel, cloves, astragalus, and Dryopteris; the compatibility ratio of the Chinese medicines is calculated in parts by weight: 30 to 90 parts of tangerine peel, 10 to 30 parts of cloves, 10 to 20 parts of astragalus and 8 to 14 parts of Dryopteris fragrans; the cloves and Dryopteris fragrans are extracted by steam distillation, and the tangerine peel and astragalus are extracted by decoction. Tangerine peel and clove are the main ingredients, astragalus is the auxiliary, and Dryopteris fragrans is the adjuvant; or bellows tree root, big lung muscle grass, and Chuangenvine are added to have anti-inflammatory, expectorant, and antiasthmatic effects. It has shown beneficial effects in a variety of animal models and also has an improvement effect on acute phase chronic obstructive pulmonary disease models. CN110742966B discloses a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease, which includes the following components by weight: 30 to 60 parts of Lanbusheng, 20 to 40 parts of Ophiopogon japonicus, 10 to 20 parts of Asparagus Asparagus, and Sichuan Fritillaria 10 to 20 parts of mother's milk, 20 to 40 parts of Baomazi skin, 25 to 50 parts of mountain red, 10 to 30 parts of Polygonatum odoratum, 10 to 20 parts of burdock, 5 to 20 parts of angelica root, 20 to 40 parts of Chinese yam (fried) . In addition, the present invention also provides a preparation method of a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease. The traditional Chinese medicine composition provided by the present invention has the functions of dispersing stagnation and reducing swelling, clearing the lungs and eliminating phlegm, nourishing yin and moisturizing dryness, producing body fluids and quenching thirst, and is suitable for lungs and rashes. It cuts into the pathogenesis of chronic obstructive pulmonary disease and is suitable for patients suffering from chronic obstructive pulmonary disease. patient. None of the above methods provide syndrome differentiation treatment based on syndrome types.

Contents of the invention

The first object of the present invention is to provide a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease; and further provide preparations and uses of the traditional Chinese medicine composition.

The first object of the present invention is achieved in this way. The traditional Chinese medicine composition for treating chronic obstructive pulmonary disease of the present invention is prepared by extracting and preparing the following traditional Chinese medicines in parts by weight: 10-20 parts of Cistanche deserticola, Morinda officinalis. 9-18 servings, Achyranthes bidentata 9-18 servings, Eucommia ulmoides 6-18 servings, Poria cocos 6-18 servings, Ginseng 10-20 servings, Gecko 5-15 servings, Scutellaria baicalensis 6-18 servings, Trichosanthes melon 15-25 servings, Salvia miltiorrhiza 15-25 parts, angelica 12-18 parts, zedoary 9-18 parts, gallbladder 6-18 parts, pinellia 10-20 parts, almond 9-18 parts, costus 6-18 parts, citrus aurantium 12-18 parts , 9-18 parts of tangerine peel, 10-20 parts of Rehmannia glutinosa, 6-18 parts of Alisma, and 5-15 parts of Plantago.

The traditional Chinese medicine composition for treating chronic obstructive pulmonary disease is prepared by extracting and preparing the following traditional Chinese medicines in parts by weight: 15 parts of Cistanche deserticola, 15 parts of Morinda officinalis, 12 parts of Achyranthes bidentata, 12 parts of Eucommia ulmoides, and 10 parts of Poria cocos. , 15 parts of ginseng, 10 parts of gecko, 12 parts of skullcap, 20 parts of trichosanthes, 20 parts of salvia, 15 parts of angelica, 12 parts of zedoary, 10 parts of bile, 15 parts of pinellia, 12 parts of almond, 15 parts of woody root, tangerine 15 parts of real fruit, 15 parts of tangerine peel, 15 parts of Rehmannia glutinosa, 12 parts of Alisma, and 10 parts of Psyllium chinensis.

According to the traditional Chinese medicine composition for treating chronic obstructive pulmonary disease, the syndrome type of chronic obstructive pulmonary disease is spleen and kidney yang deficiency type.

The traditional Chinese medicine composition for treating chronic obstructive pulmonary disease is prepared by adding medically acceptable auxiliary materials after extracting the traditional Chinese medicine, and preparing it into decoctions, granules, pills, tablets, capsules, ointments, syrups and Any kind of powder.

For the traditional Chinese medicine composition for treating chronic obstructive pulmonary disease, the granules are prepared by the following process:

(1) Decoction: Add each medicinal flavor of the formula to water according to the weight ratio of 1:10-15 and decoct it 1-3 times, 30-60 minutes each time, and combine the decoction liquid;

(2) Concentration: Concentrate the resulting decoction liquid into a thick paste at 50-75°C and -0.02--0.06MPa vacuum. The density of the thick paste at 50°C is 1.20g/ml;

(3) Drying: dry the thick paste at 50-75°C and -0.02--0.06MPa vacuum to become a dry paste for later use;

(4) Crush the dry paste and pass it through a 100-mesh sieve to obtain a mixed dry paste powder. Add granulation auxiliary materials and mix well. Add an appropriate amount of 70-90% ethanol and perform wet granulation. After drying, granules are obtained.

According to the traditional Chinese medicine composition for treating chronic obstructive pulmonary disease, the pills are prepared by the following process:

(1) Decoction: Weigh each medicinal flavor in the formula according to the formula, add water and decoct 1-3 times according to the weight ratio of the medicinal solution 1:10-15, 30-60 minutes each time, and combine the decoction liquid;

(2) Concentration: Concentrate the resulting decoction liquid into a thick paste at 50-75°C and -0.02--0.06MPa vacuum. The density of the thick paste at 50-60°C is 1.20-1.35g/ml;

(3) Drying: dry the thick paste at 50-75°C and -0.02--0.06MPa vacuum to become a dry paste for later use;

(4) Crush the dry paste and pass it through a 100-mesh sieve to obtain mixed dry paste powder. Pellet it with water or ethanol with a concentration of 30% or less to obtain pills.

Application of the traditional Chinese medicine composition in preparing medicine for treating chronic obstructive pulmonary disease of spleen and kidney yang deficiency type.

The above medicinal materials all comply with Chinese Pharmacopoeia standards.

Beneficial effects:

1. The present invention treats chronic obstructive pulmonary disease of spleen-kidney yang deficiency type through the following therapeutic principles: First, due to insufficient spleen yang, the transfer of body fluids is incompetent, water and body fluids are stagnant, and accumulation is caused by drinking, and drinking accumulates into phlegm, and phlegm follows the Qi. Upverse, the upper stem is in the lungs, which will block the airway for a long time and make breathing difficult; kidney yang is weak, and the yin and cold air in the lower burner, drinking water with the upper stem in the lungs, can cause coughing and dyspnea; the lungs govern qi, and the kidneys receive qi. The lungs are the masters of qi, and the kidneys are the roots of qi. If the lungs are deficient, purification will be lost, and if the kidneys are deficient, the qi will be unable to be received. It is difficult for clear qi to enter and for turbid qi to come out, so the chest will be full and short of breath, and movement will cause shortness of breath. Therefore, warming and nourishing the spleen and kidneys are required. Lung yang; second, spleen deficiency produces phlegm, stagnation and heat, so clearing the lung heat can also prevent excessive warming and tonifying the spleen and kidney lung yang; third, phlegm and blood stasis combined with lung distension and coughing, which will not heal over time, will not only damage the lungs and kidneys Qi, and it will inevitably lead to stasis. If the Qi is not warm, the blood will not be wet, forming a syndrome of qi and blood stagnation; the spleen is the source of phlegm, and spleen deficiency will lead to phlegm, phlegm and blood stasis, and the collaterals will be blocked. Symptoms such as excessive phlegm and saliva, dark lips and purple tongue, and blue and black hands and feet appear. For example, "Danxi Heart Method Cough" says: "Coughing due to distended lungs, or inability to sleep on the left or right side, is caused by phlegm and blood stasis that hinders Qi." Therefore, the method of activating blood circulation and removing blood stasis and dispelling wind and phlegm is adopted; the fourth is Qi is rooted in the kidneys and governs the lungs. Coughing and wheezing for a long time, if left unchecked for many years, will definitely damage the lung qi; from the lungs and kidneys, it will lead to deficiency of both lungs and kidneys. The lungs do not control the qi and become stagnant; the kidneys do not accept the qi and the qi is reversed. When it rises, it does not rise; when it falls, it does not fall. The qi of the lungs and kidneys cannot communicate with each other, so that it is difficult for clear qi to enter and for turbid qi to come out, and it becomes stagnant in the chest. Congestion in the lungs causes swelling and fullness. For example, Chao Yuanfang's "Treatise on the Causes and Symptoms of Diseases: Treating Qi Diseases" of the Sui Dynasty said: "The lungs govern Qi. If evil multiplies in the lungs, the lungs will swell. If the lungs are swollen, the lungs will be unfavorable. If it is unfavorable, the airways will be blocked, so the Qi will be reversed. ." There are also cases where the lower Yuan is exhausted due to old age and frailty, so that the Qi does not return to the root, but rushes upward, causing the lower Qi to become swollen and full, causing the lung Qi to swell and become the primary disease. Therefore, the method of regulating Qi is adopted to make the Qi smooth and smooth. The fifth reason is that when the blood is unfavorable, it will be water, which will lead to abnormal water metabolism in the lungs, spleen, and kidneys, causing the internal stasis of drinking evil, causing the heart to irritate the lungs and overflow the skin, so the method of purging turbidity and diluting water is adopted.

The present invention uses Cistanche deserticola, Morinda officinalis, Achyranthes bidentata and Eucommia ulmoides to warm and nourish the spleen and kidneys; Poria cocos and ginseng nourish the spleen; Gecko nourishes the lungs, and can nourish the kidneys, benefit essence and blood, relieve asthma and cough, and uses Scutellaria baicalensis and Trichosanthes melon to clear away heat and resolve phlegm. The traditional Chinese medicines Cistanche deserticola, Morinda officinalis, Achyranthes bidentata, Eucommia ulmoides, Poria cocos, ginseng, gecko, skullcap, and Trichosanthes melon are all monarch medicines; Salvia miltiorrhiza, Angelica sinensis, and Curcuma zedoary are activating blood circulation and removing blood stasis, and Dannanxing, Pinellia ternata, and almond are all ministerial medicines for dispelling wind and reducing phlegm. Medicines: Acosta, Citrus aurantium, and dried tangerine peel can promote qi and dissipate stagnation, regulate qi, smooth qi and eliminate phlegm. They are used as adjuvant medicines; Rehmannia glutinosa can nourish kidney water, Alisma, and Plantago seed can relieve kidney turbidity and clear it. The prescription warms the spleen, kidney and lung yang, clears away lung heat, activates blood circulation and removes blood stasis, dispels wind and phlegm, regulates qi, purges turbidity and diuresis, and can be used together to treat chronic obstructive pulmonary disease due to spleen and kidney yang deficiency.

2. A rat model of chronic obstructive pulmonary disease was constructed by using smoke combined with tracheal injection of lipopolysaccharide. The samples in Example 1 of the present invention all had a decreasing trend in serum TNF-a and had a decreasing effect on lung coefficients, suggesting that the present invention has a positive effect on chronic obstructive pulmonary disease. It has certain therapeutic effect.

3. A total of 100 patients with chronic obstructive pulmonary disease were treated in outpatient clinics. The clinical test results of the granules provided in Example 1 of the present invention showed that the total effective rate was as high as 90%, the clinical recovery rate was 42%, and the effective rate was 36%, while the control group The total effective rate was 74%, the clinical recovery rate was 24%, and the effective rate was 26%. This shows that the traditional Chinese medicine composition of the present invention is more effective than conventional treatment methods in treating chronic obstructive pulmonary disease with spleen and kidney yang deficiency. Clinical observation results show that after the 50 patients in the treatment group took the traditional Chinese medicine composition of the present invention, there were no obvious toxic or side effects, and it was safe and reliable to take.

Detailed ways

The present invention will be further described below in conjunction with specific embodiments. It should be understood that these examples are only used to illustrate the invention and are not intended to limit the scope of the invention. In addition, it should be understood that after reading the content described in the present invention, those skilled in the art can make various changes or modifications to the present invention, but these equivalent forms also fall within the scope defined by the appended claims of this application.

Example 1: Take 15g of Cistanche deserticola, 15g of Morinda officinalis, 12g of Achyranthes bidentata, 12g of Eucommia ulmoides, 10g of Poria cocos, 15g of ginseng, 10g of Gecko, 12g of skullcap, 20g of Trichosanthes trichosanthes, 20g of Salvia miltiorrhiza, 15g of Angelica sinensis, 12g of Curcuma, 10g of Dannanxing, half 15g Xia Xia, 12g almonds, 15g Koesin, 15g Citrus aurantium, 15g tangerine peel, 15g Rehmannia glutinosa, 12g Alisma, 10g Plantago, prepared by the following process:

(1) Decoction: Add each medicinal flavor of the formula to water at a potion weight ratio of 1:10 and decoct it twice, 45 minutes each time, and combine the decoction liquid;

(2) Concentration: Concentrate the resulting decoction liquid into a thick paste at 65°C and -0.05MPa vacuum. The density of the thick paste at 50°C is 1.20g/ml;

(3) Drying: dry the thick paste at 65°C and -0.05MPa vacuum to become a dry paste for later use;

(4) Crush the dry paste and pass it through a 100-mesh sieve to obtain a mixed dry paste powder. Add granulation auxiliary materials and mix well. Add an appropriate amount of 80% ethanol and perform wet granulation. After drying, granules are obtained.

Example 2: Take 10g of Cistanche deserticola, 18g of Morinda officinalis, 9g of Achyranthes bidentata, 18g of Eucommia ulmoides, 6g of Poria cocos, 20g of ginseng, 5g of Gecko, 18g of skullcap, 15g of Trichosanthes trichosanthes, 25g of Salvia miltiorrhiza, 12g of Angelica sinensis, 18g of Curcuma, 6g of Dannanxing, half 20g of Xia Xia, 9g of almonds, 18g of Acosta, 12g of Citrus aurantium, 18g of tangerine peel, 10g of Rehmannia glutinosa, 18g of Alisma and 5g of Plantago, prepared by the following process:

(1) Decoction: Add each medicinal flavor of the formula to water at a potion weight ratio of 1:12 and decoct once for 60 minutes each time, and combine the decoction liquid;

(2) Concentration: Concentrate the resulting decoction liquid into a thick paste at 50°C and -0.06MPa vacuum. The density of the thick paste at 50°C is 1.20g/ml;

(3) Drying: dry the thick paste at 50°C and -0.06MPa vacuum to become a dry paste for later use;

(4) Crush the dry paste and pass it through a 100-mesh sieve to obtain a mixed dry paste powder. Add granulation auxiliary materials and mix well. Add an appropriate amount of 70-90% ethanol and perform wet granulation. After drying, granules are obtained.

Example 3: Take 20g of Cistanche deserticola, 9g of Morinda officinalis, 18g of Achyranthes bidentata, 6g of Eucommia ulmoides, 18g of Poria cocos, 10g of ginseng, 15g of Gecko, 6g of skullcap, 25g of Trichosanthes trichosanthes, 15g of Salvia miltiorrhiza, 18g of Angelica sinensis, 9g of Curcuma, 18g of Dannanxing, half Xia Xia 10g, almond 18g, costus 6g, citrus aurantium 18g, tangerine peel 9g, rehmannia glutinosa 20g, Alisma 6g, plantain 15g, prepared by the following process:

(1) Decoction: Add each medicinal flavor of the formula to water at a potion weight ratio of 1:15 and decoct it 3 times, 30 minutes each time, and combine the decoction liquid;

(2) Concentration: Concentrate the resulting decoction liquid into a thick paste at 75°C and -0.02MPa vacuum. The density of the thick paste at 50°C is 1.20g/ml;

(3) Drying: dry the thick paste at 75°C and -0.06MPa vacuum to become a dry paste for later use;

(4) Crush the dry paste and pass it through a 100-mesh sieve to obtain a mixed dry paste powder. Add granulation auxiliary materials and mix well. Add an appropriate amount of 90% ethanol and perform wet granulation. After drying, granules are obtained.

Example 4: Take 15g of Cistanche deserticola, 15g of Morinda officinalis, 12g of Achyranthes bidentata, 12g of Eucommia ulmoides, 10g of Poria cocos, 15g of ginseng, 10g of Gecko, 12g of skullcap, 20g of Trichosanthes trichosanthes, 20g of Salvia miltiorrhiza, 15g of Angelica sinensis, 12g of Curcuma, 10g of Dannanxing, half 15g Xia Xia, 12g almonds, 15g Koesin, 15g Citrus aurantium, 15g tangerine peel, 15g Rehmannia glutinosa, 12g Alisma, 10g Plantago, prepared by the following process:

(1) Decoction: Weigh each medicinal flavor in the formula according to the formula, add water and decoct it twice with a potion weight ratio of 1:12, 45 minutes each time, and combine the decoction liquid;

(2) Concentration: Concentrate the resulting decoction liquid into a thick paste at 6°C and -0.05MPa vacuum. The density of the thick paste at 50-60°C is 1.25g/ml;

(3) Drying: dry the thick paste at 65°C and -0.05MPa vacuum to become a dry paste for later use;

(4) Crush the dry paste and pass it through a 100-mesh sieve to obtain mixed dry paste powder. Pellet it with water or ethanol with a concentration of 30% or less to obtain pills.

Example 5: Take 15g of Cistanche deserticola, 15g of Morinda officinalis, 12g of Achyranthes bidentata, 12g of Eucommia ulmoides, 10g of Poria cocos, 15g of ginseng, 10g of Gecko, 12g of skullcap, 20g of Trichosanthes trichosanthes, 20g of Salvia miltiorrhiza, 15g of Angelica sinensis, 12g of Curcuma, 10g of Dannanxing, half 15g Xia Xia, 12g almonds, 15g Koesin, 15g Citrus aurantium, 15g tangerine peel, 15g Rehmannia glutinosa, 12g Alisma, 10g Plantago, prepared by the following process:

(1) Decoction: Weigh each medicinal flavor in the formula according to the formula, add water and decoct it twice with a potion weight ratio of 1:12, 45 minutes each time, and combine the decoction liquid;

(2) Concentration: Concentrate the resulting decoction liquid into a thick paste at 6°C and -0.05MPa vacuum. The density of the thick paste at 50-60°C is 1.25g/ml;

(3) Drying: dry the thick paste at 65°C and -0.05MPa vacuum to become a dry paste for later use;

(4) Crush the dry paste and pass it through a 100-mesh sieve to mix the dry paste powder with water and honey to make a syrup.

Example 6: Anti-inflammatory effect and impact on lung organ coefficients in chronic obstructive pulmonary disease model rats

1. Grouping of experimental animals

Thirty clean-grade healthy Wistar rats, half male and half, 10 to 12 weeks old, weighing (230±20) g, were reared adaptively for 7 days and then raised in cages at room temperature (25±1)°C, with sufficient food and Drinking water, 12h day/night cycle every day, randomly divided into blank group, model group and medication group, with 10 animals in each group.

2. Use smoke combined with tracheal injection of lipopolysaccharide to construct a rat COPD model

Rats were grouped into a closed box and given filtered cigarettes (tar content 11 mg, nicotine content 0.8 mg, CO content 14 mg), smoked at a smoke concentration of 5%, 2 times/d, 0.5h/time, 2 times apart. The time is 8h, a total of 60d. On the 10th, 20th, and 40th day, no smoke was given, and lipopolysaccharide (200 μg/200 μL) was injected into the trachea. The rats in the blank control group were placed in a closed box but not smoked. The time and intervals were the same as those in the COPD model group. On the 10th, 20th and 40th days, the same amount of normal saline was injected into the trachea. The rats in the administration group were administered intragastrically at a prescribed dose 30 minutes before smoking every day (the traditional Chinese medicine granules described in Example 1). Except for the time in the closed box, the three groups of rats were raised in the same environment, and the modeling was completed in 10 weeks.

At the end of the experiment, the surviving animals in each group were weighed, blood was collected, and the serum was separated by centrifugation. The TNF-a content in the serum was measured by Elisa method. After blood collection, the surviving animals in each group were killed, the lungs were taken, the lung wet weight was measured, and the lung coefficient was calculated. Lung coefficient (%)=100*lung wet weight/animal weight. The lung coefficient and serum TNF-a content of rats in each group are shown in Table 1.

Table 1 Lung coefficient and serum TNF-a content of rats in each group

Group TNF-a content (pg/mL) Lung coefficient (%) Blank group 335.12±47.09 0.53±0.08 model group 398.54±56.78 0.81±0.05 Example 1 group 341.70±50.13** 0.52±0.06**

*p<0.05 compared with the model group; **p<0.01 compared with the model group.

3. Conclusion: The sample of Example 1 has a reducing effect on serum TNF-a and the lung coefficient, indicating that the present invention has a certain therapeutic effect on chronic obstructive pulmonary disease.

Example 7: Clinical Study

1. Clinical data: Since 2019, our outpatient clinic has treated a total of 100 patients with chronic obstructive pulmonary disease. Among them, there were 67 males and 33 females, aged 45-74 years old. They were diagnosed by traditional Chinese medicine as spleen and kidney yang deficiency. Symptoms include chest tightness and shortness of breath, more breathing and less breathing, asthma when moving, spontaneous cold sweats, lukewarm limbs, and fear. Cold and timid, long and clear urine or incontinence, pale tongue, tender and fat tongue, and thin pulse.

2. Randomly divide into two groups, namely the treatment group and the control group for intervention research. The treatment group takes the granules prepared in Example 1 of the present invention (daily dosage: Cistanche deserticola 15g, Morinda officinalis 15g, Achyranthes bidentata 12g, Eucommia ulmoides 12g , Poria 10g, ginseng 15g, Gecko 10g, skullcap 12g, Trichosanthes melon 20g, Salvia miltiorrhiza 20g, Angelica sinensis 15g, Curcuma zedoary 12g, Dananxing 10g, Pinellia 15g, almond 12g, Agarwood 15g, Citrus aurantium 15g, Tangerine peel 15g, Rehmannia glutinosa 15g, Alisma 12g, Plantago 10g), the control group took Suzi Jiangqi Pills (produced by Jilin Zixin Prajna Pharmaceutical Co., Ltd., national drug approval number Z20063628, batch number: 20190508), 6 grams each time (1 bag at a time) , 1-2 times a day.

3. Efficacy standards: recovery: no dyspnea, no cough, no phlegm coughed up, and pulmonary rales disappear; marked effect: no dyspnea, the number of coughs is significantly reduced, the amount of sputum is significantly reduced, and the pulmonary rales are significantly reduced or disappeared; Effective: dyspnea is relieved, the number of coughs is reduced, the amount of sputum is slightly reduced, and the rales in the lungs are slightly reduced; Ineffective: the physical signs are not significantly improved, or even worsened.

4. The results are shown in Table 2.

Table 2 Clinical efficacy of the present invention in treating chronic obstructive pulmonary disease of spleen and kidney yang deficiency type

Group get well Effective efficient invalid Total effectiveness (%) Example 1 group twenty one 18 6 5 90 control group 12 13 12 13 74

5. Conclusion: It can be seen from Table 2 that the clinical recovery rate, significant efficiency, and total effective rate of the two groups of patients are all P<0.05, and there is a significant difference. The clinical test results of the granules provided in Example 1 of the present invention It shows that the total effective rate is as high as 90%, the clinical recovery rate is 42%, and the effective rate is 36%, while the total effective rate of the control group is 74%, the clinical recovery rate is 24%, and the effective rate is 26%. This shows that the traditional Chinese medicine composition of the present invention treats the spleen. The efficacy of chronic obstructive pulmonary disease with kidney-yang deficiency is better than conventional treatments. Clinical observation results show that after the 50 patients in the treatment group took the traditional Chinese medicine composition of the present invention, there were no obvious toxic or side effects, and it was safe and reliable to take. In summary, the traditional Chinese medicine composition of the present invention has the advantages of significant curative effect on patients with chronic obstructive pulmonary disease of spleen and kidney yang deficiency type, no toxic side effects, and its preparation process is safe and stable. This also further illustrates that the traditional Chinese medicine composition of the present invention has good market application prospects.

Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art will understand that various changes, modifications, and substitutions can be made to these embodiments without departing from the principles and spirit of the invention. and modifications, the scope of the invention is defined by the appended claims and their equivalents.

Claims (7)

1. The traditional Chinese medicine composition for treating the chronic obstructive pulmonary disease is characterized by being prepared by extracting the following traditional Chinese medicines in parts by weight: 10-20 parts of cistanche, 9-18 parts of morinda officinalis, 9-18 parts of achyranthes bidentata, 6-18 parts of eucommia ulmoides, 6-18 parts of poria cocos, 10-20 parts of ginseng, 5-15 parts of gecko, 6-18 parts of scutellaria baicalensis, 15-25 parts of snakegourd fruit, 15-25 parts of radix salviae miltiorrhizae, 12-18 parts of angelica sinensis, 9-18 parts of curcuma zedoary, 6-18 parts of arisaema cum bile, 10-20 parts of pinellia ternate, 9-18 parts of almond, 6-18 parts of costustoot, 12-18 parts of immature bitter orange, 9-18 parts of dried orange peel, 10-20 parts of prepared rehmannia root, 6-18 parts of rhizoma alismatis and 5-15 parts of plantain seed.

2. The traditional Chinese medicine composition for treating chronic obstructive pulmonary disease according to claim 1, wherein the traditional Chinese medicine composition is prepared by extracting the following traditional Chinese medicines in parts by weight: 15 parts of cistanche, 15 parts of morinda officinalis, 12 parts of achyranthes, 12 parts of eucommia ulmoides, 10 parts of poria cocos, 15 parts of ginseng, 10 parts of gecko, 12 parts of scutellaria baicalensis, 20 parts of snakegourd fruit, 20 parts of radix salviae miltiorrhizae, 15 parts of angelica sinensis, 12 parts of rhizoma curcumae, 10 parts of arisaema cum bile, 15 parts of pinellia ternate, 12 parts of almond, 15 parts of costustoot, 15 parts of immature bitter orange, 15 parts of dried orange peel, 15 parts of prepared rehmannia root, 12 parts of rhizoma alismatis and 10 parts of plantain seed.

3. The traditional Chinese medicine composition for treating chronic obstructive pulmonary disease according to claim 1, wherein the chronic obstructive pulmonary disease is of spleen-kidney yang deficiency type.

4. The traditional Chinese medicine composition for treating chronic obstructive pulmonary disease according to claim 1, wherein the traditional Chinese medicine composition is prepared into any one of decoction, granules, pills, tablets, capsules, ointment, syrup and powder by adding pharmaceutically acceptable auxiliary materials after extraction of the traditional Chinese medicine.

5. The traditional Chinese medicine composition for treating chronic obstructive pulmonary disease according to claim 1, wherein the granule is prepared by the following process:

(1) Decocting: the weight ratio of each medicine ingredient in the prescription is 1:10-15, decocting in water for 1-3 times each for 30-60min, and mixing decoctions;

(2) Concentrating: concentrating the decoction at 50-75deg.C and vacuum degree of-0.02-0.06 MPa to obtain soft extract with density of 1.20g/ml at 50deg.C;

(3) And (3) drying: drying the thick paste at 50-75deg.C and-0.02-0.06 MPa to obtain dry paste for use;

(4) Pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, adding granulating adjuvants, mixing, adding appropriate amount of 70-90% ethanol, wet granulating, and drying to obtain granule.

6. The traditional Chinese medicine composition for treating chronic obstructive pulmonary disease according to claim 1, wherein the pill is prepared by the following process:

(1) Decocting: weighing the medicinal herbs in the formula according to the formula weight ratio of 1:10-15, decocting in water for 1-3 times each for 30-60min, and mixing decoctions;

(2) Concentrating: concentrating the decoction at 50-75deg.C and vacuum degree of-0.02-0.06 MPa to obtain soft extract with density of 1.20-1.35g/ml at 50-60deg.C;

(3) And (3) drying: drying the thick paste at 50-75deg.C and-0.02-0.06 MPa to obtain dry paste for use;

(4) Pulverizing the dry extract, sieving with 100 mesh sieve to obtain mixed dry extract powder, and making pill with water or 30% or below ethanol to obtain pill.

7. Use of a Chinese medicinal composition according to any one of claims 1-3 in the manufacture of a medicament for the treatment of chronic obstructive pulmonary disease due to spleen-kidney yang deficiency.