CN117223741A - Traditional Chinese medicine diet for improving constipation and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicinal diet and discloses a traditional Chinese medicinal diet for improving constipation and a preparation method thereof. The traditional Chinese medicinal diet for improving constipation of the present invention contains almonds, bergamot, platycodon, malt, yam, hawthorn, Gallus gallus gallus gallus gallinae, Yu Liren, perilla seeds, hemp seeds, plantain husk and okra powder as active ingredients. The traditional Chinese medicinal diet of the present invention is based on more than ten years of clinical diagnosis and treatment experience of chronic constipation in traditional Chinese medicine, combined with solid theoretical basic research of traditional Chinese medicine. Its safety and effectiveness in the prevention and treatment of chronic constipation have been clinically verified for a long time.

Description

A kind of traditional Chinese medicinal diet for improving constipation and its preparation method

Technical field

The present invention relates to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicinal diet for improving constipation and a preparation method thereof.

Background technique

Chronic constipation has a high incidence rate and great harm, and can cause great pain to patients. Changes in dietary structure and eating habits coupled with unscientific lifestyles have led to an increasing incidence of chronic constipation, which has become a common and frequently-occurring disease that affects the quality of life of modern people. Chronic constipation also leads to other anorectal diseases and urinary system diseases. The exacerbation of diseases and cardiovascular and cerebrovascular diseases can cause mental illness such as anxiety and depression. However, most of the drugs on the market for the treatment of chronic constipation are stimulant laxatives containing anthraquinones, which have quick effects but significant side effects. They can easily lead to intractable laxative-dependent constipation, colonic melanosis, and an increase in tumors and polyps. incidence rate.

In recent years, the "circular motion" theory has received more and more attention from traditional Chinese medicine scholars. Based on the circular theory of qi movement, the traditional Chinese medicine pathogenesis of constipation can be analyzed. Qi movement is the key to human life activities. If the movement of Qi movement is normal, all physiological activities of the human body will proceed in an orderly and coordinated manner. If the movement of Qi is out of balance, the physiological functions of the human body will be disrupted and all kinds of diseases will arise. Rising, falling, floating and sinking are the "circular movements" of the human body's qi. The physiological mechanisms and pathological changes of the human body are unified by the "circular movement" of the qi. That is to say, the life activities of the human body are just a miniature qi. circular motion. The physiology of "circular motion" is that "the axis moves and the wheel moves, and the wheel moves the axis." The pathology of "circular motion" is that "the axis does not rotate, and the wheel does not rise or fall." The stagnant diet will damage the spleen and stomach, and the spleen and stomach's transportation and transformation functions will fail. As a result, the axis of the spleen and stomach will not rotate, and spleen yang will not rise and stomach qi will not fall. At the same time, modern people are prone to have liver qi that attacks the spleen and stomach due to poor emotions, and the lungs are ineffective and body fluids cannot be discharged. They may suffer from intestinal dryness and constipation, and kidney qi deficiency, which cannot warm the spleen yang, promote the transportation and transformation of the spleen and stomach, and promote the spleen and stomach. Descending, spleen and stomach ascend clear and descend turbidity, constipation due to constipation of intestinal dryness.

Traditional Chinese medicinal diet is a delicious food based on traditional Chinese medicine as the theoretical basis, using drugs (TCM) and food as the main raw materials, using Chinese cooking techniques as the basic means, and with the fundamental purpose of maintaining health and fitness, preventing and curing diseases. Traditional Chinese medicine has always attached great importance to dietary supplements, medicated diets and dietary therapies. The earliest extant traditional Chinese medicine theory classic in my country, the Huangdi Neijing, puts forward the concept of dietary nourishment. There are records of dietary therapy in monographs such as "Book" and "Yinshan Zhengyao" written by Hu Sihui of the Yuan Dynasty. Many of the animal and plant medicinal materials recorded in "Shen Nong's Materia Medica" and "Compendium of Materia Medica" are both medicinal and dietary. daily food. There are many traditional Chinese medicine and dietary prescriptions for chronic constipation, but due to the lack of guidance from traditional Chinese medicine theory, there are cases of abuse and misuse, and they cannot meet people's needs. Therefore, it is necessary to develop safe and effective traditional Chinese medicine diet to improve chronic constipation that is consistent with my country's national conditions.

Contents of the invention

The purpose of the present invention is to overcome the above-mentioned deficiencies in the background technology and provide a Chinese medicinal diet for improving constipation and a preparation method thereof in combination with the theory of qi movement and circle. The traditional Chinese medicinal diet for improving constipation of the present invention is obtained from more than ten years of clinical diagnosis and treatment experience of chronic constipation combined with solid theoretical basic research of traditional Chinese medicine. It does not contain rhubarb, senna, aloe, cassia, polygonum multiflorum and other anthraquinone-rich substances. The stimulant laxative ingredient has long been clinically proven to be safe and effective in preventing and treating chronic constipation.

In order to achieve the purpose of the present invention, the traditional Chinese medicinal diet for improving constipation of the present invention contains almonds, bergamot, platycodon, malt, yam, hawthorn, gallinaceae, Yuliren, perilla seeds, hemp seeds, plantain husk and autumn leaves. Sunflower powder as active ingredient.

The above-mentioned traditional Chinese medicinal diet is based on the existing medicated dietary biscuits. The relatively greasy Polygonatum japonica has been removed to avoid hindering the transportation function of the spleen and stomach. It does not contain chia seeds, shiitake mushrooms, white fungus, celery, and low water-soluble dietary fiber content. Polyfructose is added with almonds and perilla seeds to strengthen the lungs and moisturize the intestines. In addition, plum kernels and hemp seeds are added to moisturize the intestines and relieve constipation.

The ingredients of the traditional Chinese medicine diet of the present invention are selected based on the physiological and pathological conditions and improvement plans of the Qi Yuan theory. Among them, hawthorn, Gallus gallus gallus gallinae, malt are used for digestion and spleen strengthening, and for complex axis rotation. Bergamot and malt soothe the liver and relieve depression, and regulate the rise and fall of the wood chakra. Yams nourish the spleen and stomach, promote the production of body fluids and lungs, nourish the kidneys and replenish qi and promote the production of body fluids. The three internal organs of the spleen, lungs and kidneys are unblocked, and the qi machine drives powerfully and rotates in a double axis. Platycodon calms the lungs, while almonds and perilla seeds lower qi, both rising and falling. Body fluids are distributed and the intestines are nourished and lubricated. Almonds, hemp seeds, and plum blossoms nourish the intestines. These drugs work together to achieve a rotational movement. In addition, psyllium husk and okra powder are rich in dietary fiber and trace elements, which can increase stool volume, soften stool, stimulate intestinal peristalsis, improve the intestinal flora environment, thereby enhancing human defecation function.

Further, in some embodiments of the present invention, the traditional Chinese medicinal diet for improving constipation includes 6-18 parts by weight of almonds, 6-18 parts of bergamot, 15-45 parts of yam, 6-18 parts of hawthorn, 6-18 parts of Gallus gallus gallus L., 6-18 parts of Platycodon grandiflorum, 6-18 parts of malt, 2-18 parts of Yuliren, 2-18 parts of Perilla seeds, 2-18 parts of Hemp seeds, 1 part of Psyllium husk powder -45 parts, okra powder 1-18 parts.

Further, in some embodiments of the present invention, the Chinese medicinal diet for improving constipation is biscuits.

Further, in some embodiments of the present invention, the biscuit contains 6-18 parts by weight of almonds, 6-18 parts of bergamot, 15-45 parts of yam, 6-18 parts of hawthorn, and 6 parts of Gallus gallus gallus L. -18 parts, platycodon 6-18 parts, malt 6-18 parts, plum kernels 2-18 parts, perilla seeds 2-18 parts, hemp seeds 2-18 parts, psyllium husk powder 1-45 parts, Okra powder 1-18 parts, flour 610 parts.

Further, the present invention also provides a method for preparing the aforementioned traditional Chinese medicine biscuits for improving constipation, which method includes the following steps:

(1) Prepare medicinal powder: ultrafinely crush almonds, bergamot, yam, hawthorn, Gallus gallus gallus L., Platycodon grandiflorum, malt, plum kernels, perilla seeds, and hemp seeds, and then mix with plantain husk powder and okra powder. well mixed;

(2) Mix flour and dough: Add water, palm oil, and white sugar to the powder in sequence, stir, add flour, and mix until there is no dry powder and the dough has no gluten;

(3) Forming: Use molds to make biscuit blanks of various shapes;

(4) Baking: control the temperature for baking;

(5) Oil spray: spray palm oil evenly;

(6) Cooling and finishing: After baking, the biscuits are cooled to room temperature and transferred to the packaging room;

(7) Packaging.

Further, in some embodiments of the present invention, the fineness of 200-400 mesh is achieved after ultrafine grinding in step (1).

Further, in some embodiments of the present invention, the temperature control in step (4) is 170-260°C for upper heat and 160-240°C for lower heat.

Further, in some embodiments of the present invention, the control standard for the amount of oil injected in step (5) is: weigh 10 biscuits before and after spraying, and if the weight increases by 10-20%, the amount of oil injected reaches the standard. Require.

Compared with the prior art, the advantages of the present invention are as follows:

(1) In the present invention, traditional Chinese medicines such as almonds, bergamot, platycodon, malt, yam, hawthorn, Gallus gallus gallus gallinae, Yuliren, perilla seeds, hemp seeds, plantain husk, okra powder and other traditional Chinese medicines are used in combination to nourish the spleen and nourish the body. It has the effect of widening the intestines and lowering Qi, producing body fluids, moistening the intestines and laxative. It can be used to treat weak spleen-spleen conduction in the large intestine, dry body fluid unable to moisten the large intestine, stagnation of Qi, abnormal circulation, failure of large intestine conduction, resulting in constipation, bloating, and belching. Supplementary or alternative drug treatment for symptoms such as fullness in the chest and flanks, weakness during defecation, and fatigue and discomfort after defecation.

(2) The clinical research project for refractory diseases of the Provincial Administration of Traditional Chinese Medicine completed in the early stage of this invention, "Clinical Research on a Traditional Chinese Medicinal Diet for the Treatment of Slow Transit Constipation", studied 185 cases, the clinical cure rate was 67.75%, and the effective rate was 91.68% , 100% effective.

(3) The traditional Chinese medicinal diet for improving constipation of the present invention is mainly aimed at people with chronic constipation, fully develops the service characteristics of traditional Chinese medicine diet therapy and food maintenance, improves the quality of life of people with habitual constipation, and at the same time reduces medical expenses for the society and promotes The continuous development of traditional Chinese medicine health food.

Detailed ways

In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with examples. Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. It should be understood that the following description is only used to explain the present invention and is not intended to limit the present invention.

As used herein, the terms "includes," "includes," "has," "contains," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, step, method, article, or device that includes listed elements need not be limited to those elements, but may include other elements not expressly listed or inherent to such composition, step, method, article, or device. elements.

When an amount, concentration, or other value or parameter is expressed in terms of a range, a preferred range, or a range defined by a series of upper preferred values and lower preferred values, this should be understood to specifically disclose any upper range limit or preferred value and any lower range limit. or any pairing of preferred values, whether or not that range is individually disclosed. For example, when the range "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4," "1 to 3," "1 to 2," "1 to 2, and 4 to 5." , "1 to 3 and 5" etc. When a numerical range is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The indefinite articles "a" and "an" before the elements or components of the present invention do not limit the quantity requirements (ie, the number of occurrences) of the elements or components. Therefore "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural form, unless it is obvious that the stated number refers to the singular form only.

In addition, the following description of the terms "one embodiment", "some embodiments", "example", "specific examples", or "some examples" means specific features, structures described in connection with the embodiment or examples. , materials or features are included in at least one embodiment or example of the invention. In this specification, the schematic expressions of the above terms are not necessarily directed to the same embodiment or example. Moreover, the technical features involved in the various embodiments of the present invention can be combined with each other as long as they do not conflict with each other.

Example 1

Study on the efficacy of constipation medicinal diet on animals with slow transit constipation

Reagents: Serum NO and eNOS detection kits were purchased from Nanjing Jiancheng Bioengineering Institute; India ink (Beijing Nobleled Technology Co., Ltd., batch number: 20160217); chloral hydrate (Tianjin Comio Chemical Reagent Co., Ltd., batch number : 20140629); calcium detection kit (Roche Diagnostic Products Shanghai Co., Ltd., batch number: 20161201); hematoxylin and eosin (Bioswamp Co., Ltd.); medicated diet was made by the laboratory.

Experimental animals: SPF grade healthy Kunming rats, weighing (200±20) g, 40 females and 40 males, all kept under controllable conditions (room temperature maintained at 22±2°C, humidity maintained at 50%-70%) animal room.

Preparation of STC model: According to the method in the literature, the rhubarb-induced diarrhea colon model was used to model the colon. Except for the normal group, the other rats were given rhubarb at a dose of 150 mg/(kg·d) by gavage, and then the gavage dose was 150 mg/(kg·d). Incrementally increase until 50% of the rats have diarrhea, maintain this dose until 80% of the rats have loose stools disappear, and then increase by 150 mg/(kg·d) until 50% of the rats have diarrhea and maintain the dose again to 80% of the rats. If the rat is constipated, then increase the dose, and repeat this cycle 3 times. Until the third time when 80% of the rats' loose stools disappeared, the dose was maintained and continued for 1 week. It was found that the rats' hair was dry and irritable, the amount of feces was significantly reduced, the texture was hard, and the water content of the feces was significantly reduced, indicating slow transmission. The sexual constipation model was successfully replicated.

Success criteria for modeling: Rats have poor mental state, irritable and irritable temperament, thin appearance, yellow and loose hair, lack of luster, and even piloerection, soft skin, partial arched back, prolapse of the anus, reduced activity, reduced food intake, and constipation. In the early stage of the mold, the stool is loose and frequent. In the later stage, the stool gradually takes shape and becomes hard, the frequency decreases, and the particles become smaller. The anatomy of the digestive tract of rats showed that feces mainly gathered in the colon and were in the shape of beads. There were no obvious fecal residues in the jejunum and ileum. The intestinal propulsion rate and serum D-xylose content of rats were significantly lower than those of normal mice, indicating that The model was successful.

Example 2

The traditional Chinese medicinal diet for improving constipation in experiments of the present invention and the traditional Chinese medicinal diet for improving constipation in the prior art are prepared according to the following process flow:

1. Acceptance of raw and auxiliary materials: the product quality is qualified and valid verification data is provided. The raw and auxiliary materials included in the production license must provide a product production license; among them, the effective component ratio of the medicated dietary formula of the present invention is: 6g almond, 6g bergamot, yam 15g, hawthorn 6g, Gallus gallus gallus L. 6g, platycodon 6g, malt 6g, plum blossom kernel 2g, perilla seed 2g, hemp seed 2g are ultrafinely crushed to a fineness of 200-400 mesh, and 3g of plantain husk powder , 3g okra powder and mix evenly; the effective composition distribution ratio of the original medicinal formula is: 10g polygonatum, 6g bergamot, 15g yam, 6g hawthorn, 6g gallinaceus, 6g platycodon, 6g malt, 1g chia seeds through ultra-fine grinding , to a fineness of 200-400 mesh, mix evenly with 1g of plantain husk powder, 1g of okra powder, 1g of shiitake mushroom powder, 1g of tremella powder, 1g of celery powder, and 1g of fructooligosaccharide.

2. Mix flour and dough: In the medicinal diet, add water, palm oil, white sugar and other ingredients in sequence, stir for about 10 minutes, then add 610g of flour, stir for 3-5 minutes until there is no dry powder and the dough has no gluten. The water temperature is required to be around 28°C. Replenishing water or the amount of water is slightly more than the ingredient ratio, the temperature is higher than the control requirement, and the mixing time is slightly longer, etc., which can destroy the crispy structure.

3. Forming: Put the dough into the hopper and use various types of molding machines to make biscuit blanks of various shapes.

4. Baking: The temperature of the baking oven and the baking time of the biscuit dough. The first zone of the oven temperature is set to upper heat: about 170°C, and the lower heat is about 160°C. The second zone is set to upper heat: about 230°C. The lower fire is about 210℃, the third zone is set to upper fire: about 260℃, the lower fire is about 240℃, the fourth zone is set to upper fire: about 250℃, the lower fire is about 230℃, the fifth zone is set to upper fire: The temperature is about 240℃, the lower fire is about 220℃, the six zones are set to the upper fire: about 220℃, the lower fire is about 210℃, the crawler speed is 600~900, and the moisture content of the finished product is ≤4%.

5. Oil injection: The medicated diet of the present invention is preheated with palm oil and controlled at about 35°C. The amount of oil injection is controlled by the upper and lower valves of the oil injection machine. Weigh 10 biscuits before and after spraying, and the weight will increase by about 15%. The oil quantity meets the standard requirements. The original medicinal diet uses a mixture of palm oil, perilla seed oil, and hemp seed oil to be preheated and controlled at about 35°C. The amount of oil injection is controlled by the upper and lower valves of the oil injection machine. Weigh 10 biscuits before and after spraying, and the weight increases. About 15%, the fuel injection volume meets the standard requirements.

6. Cooling and finishing: After baking, the biscuits are cooled to room temperature, transported by the conveyor belt, cooled, and then transferred to the inner packaging room.

7. Packaging.

Example 3

Group administration: Male and female rats were separated and adaptively fed for 7 days. They were divided into a normal group (10 rats) and a modeling group (60 rats) according to a random number table. Then, the 60 rats that were successfully modeled were randomly divided into They are the model group (STC, 10 animals), the mosapride group (2.5 mg/kg/d, 10 animals), the original medicated diet low-dose group (biscuits: 10g/kg/d, 10 animals), and the original medicated diet high-dose group. (biscuits: 30g/kg/d, 10 pieces), the medicated diet low-dose group of the present invention (biscuits: 10g/kg/d, 10 pieces), the medicated diet high-dose group of the invention (biscuits: 30g/kg/d, 10 pieces) . Rats in the STC group were given an equal volume of normal saline by gavage every day for 14 days, twice a day.

Observe evaluation indicators

General Behavior: During the period from modeling to material collection, the mental state, reactivity, fur, eating conditions, and changes in stool quality and quantity of rats in each group were observed every day.

24h total feces volume and fecal moisture content: Collect the total 24h feces volume of rats in each group after modeling and administration, record the number of particles, and call it wet mass (A). Put the feces into a drying box to dry for 3 hours, and call it dry mass. (B), calculate fecal water content = (A-B)/A×100%.

Defecation situation: The rats were fasted and water-free for 24 hours. India ink was orally poured into the stomachs of the rats (2ml/rat). The timing started immediately after the end of the gastric administration. The rats were continuously observed for 6 hours, and each rat was recorded from the time of gastric administration. The time until the first feces is excreted, and the number and quality of the rat's feces within 6 hours are recorded.

Small intestinal propulsion test: At the end of the experiment, the rats were fasted for 12 hours, and then 10% activated carbon suspension was administered to the rats, 2 mL of which was administered to each rat. After 30 minutes, the rats were anesthetized and the abdominal cavity was exposed. The small intestinal tube from the pylorus to the ileocecal part was taken out and gently straightened. The length of carbon powder advancement (cm) and the total length of the small intestinal tube (cm) were measured. Carbon powder advancement rate (%) = Carbon powder advancement length/total length of small intestine × 100%.

ELISA measurement: ELISA method was used to detect the expression of NO, cGMP, and PKG in the colon of rats. Take 1.5cm of the colon from the rats in each group 11cm away from the anus, rinse it with physiological saline, homogenize the specimen fully with a homogenizer, and centrifuge at 2500r/min. 20min, collect the supernatant. The ELISA method was used to measure the levels of NO, cGMP, and PKG in mouse colon tissue. The specific method was carried out according to the instructions of the kit.

ELISA method was used to detect the contents of substance P (SP), vasoactive intestinal peptide (VIP), and somatostatin (SS) in serum. Take the serum of rats from each group, thaw it and dilute it to an appropriate concentration. Add 50 μL to each well, and follow the ELISA reagents. Box method determination.

Example 4

SPSS18.0 statistical software was used for processing and analysis. The measurement data were expressed as (x±s). First, the homogeneity of variances was tested. One-way analysis of variance was used for comparison between each group. LSD method was used for comparison between two groups. P<0.05 was considered a difference. Statistical significance.

Comparison of the total 24-hour feces volume and fecal water content of STC rats in each group: After modeling, the 24-hour total feces volume and fecal water content of rats in the model group were significantly lower than those of the normal group, and the difference was statistically significant (P<0.05); After taking the medicine, the conditions of the rats in the high and low dose groups of the medicated diet of the present invention, the high and low dose groups of the original medicated diet, and the mosapride group all improved; the texture of the feces of the rats in the high and low dose groups of the medicated diet and the mosapride group became softer, and their feces after 24 hours became softer. The total volume and fecal water content were higher than those of the model group, and the difference was statistically significant (P<0.05), suggesting that medicated diet can increase the total volume and water content of feces in STC rats and improve constipation symptoms. At the same time, the total 24-hour feces of rats in the high-dose medicated diet group of the present invention is higher than that of the original medicated diet high-dose group, and the total 24-hour feces of rats in the low-dose medicated diet group of the present invention is higher than that of the original medicated diet low-dose group. Therefore, the medicated diet of the present invention is more efficient than the original medicated diet. Can increase the total amount of feces in STC rats.

Table 1 Comparison of the total feces volume of STC rats in each group in 24 hours

Note: Comparing the model group with the normal group, ▲P<0.05; Comparing the drug administration group with the model group, *P<0.05

Table 2 Comparison of fecal water content of STC rats in each group

Note: Comparing the model group with the normal group, ▲P<0.05; Comparing the drug administration group with the model group, *P<0.05

Effect of medicated diet on intestinal propulsion function of STC rats: The results showed that the first urinary defecation time of rats in the model group was significantly longer than that of the normal group, and the charcoal propulsion rate was significantly lower than that of the normal group (P<0.05), indicating that the STC model caused rats The intestinal propulsion function is weakened; the time to first defecation of black stool in the high- and low-dose medicated diet groups and the mosapride group is significantly shorter than that in the model group. The charcoal propulsion rate of rats in each administration group is significantly higher than that in the model group, and the difference is statistically significant. Significance (P<0.05), suggesting that the medicated diet can enhance the intestinal transmission function of STC rats. At the same time, the time for the first black stool and the charcoal propelling rate of the rats in the high-dose medicated diet group of the present invention were better than those of the original medicated high-dose group. The time and the charcoal propelling rate of the rats in the low-dose medicated diet group of the present invention were both better than The original medicated diet low-dose group, therefore, it is suggested that the medicated diet of the present invention can better enhance the intestinal transmission function of STC rats.

Table 3 Comparison of intestinal transmission function of STC rats in each group

Note: Comparing the model group with the normal group, ▲P<0.05; Comparing the drug administration group with the model group, *P<0.05

Effects of medicinal diet on the expression of NO, cGMP and PKG in the colon tissue of STC rats: Some studies believe that slow transit constipation is related to the disorder of the enteric nervous system. The enteric nervous system directly controls the movement of intestinal smooth muscles by releasing neurotransmitters, among which inhibitory nerves The transmitter nitric oxide (NO) plays an important role. Increased NO synthesis can lead to the occurrence of slow transit constipation. The main reason is that NO can combine with guanylyl cyclase (GC) to increase the production of cGMP. As a second messenger, cGMP is the central link of this signaling pathway. It can act on downstream proteins, among which PKG is involved in biological signal transmission, cell proliferation and apoptosis, inhibition of intestinal peristalsis and other biological effects.

The research results of the present invention show that the expressions of NO, cGMP and PKG in the colon of rats in the model group are significantly higher than those in the normal group, and the difference is statistically significant (P<0.05); after 2 weeks of administration, the expression of NO, cGMP and PKG in the colon of rats in the model group was significantly higher than that of the moxa group. The expressions of NO, cGMP and PKG in the colon of rats in the Bili group were lower than those in the model group, and the differences were statistically significant (P<0.05). At the same time, the expressions of NO, cGMP and PKG in the colon of rats in the high-dose medicated diet group of the present invention are all lower than those in the original medicated diet high-dose group. The expressions of NO, cGMP and PKG in the colon of rats in the low-dose medicated diet group of the present invention are all lower than those in the original medicated diet low-dose group. .

Table 4 Comparison of the expression of biochemical factors in colon tissue of STC rats in each group

Note: Comparing the model group with the normal group, ▲P<0.05; Comparing the drug administration group with the model group, *P<0.05

Effect of medicated diet on the expression of SP, VIP, and SS in the serum of STC rats: SP is the main gastrointestinal hormone, which can directly accelerate the contraction movement of the colon and stimulate the contraction of the smooth muscle of the digestive tract; VIP can inhibit intestinal relaxation, inhibit colon and rectum The tension directly affects the occurrence of constipation; SS, as an inhibitory neurotransmitter in the enteric nervous system, can regulate the secretion and release of intestinal peptide hormones and inhibit gastrointestinal motility. Compared with the blank group, the SP content in the serum of rats in the model group was significantly reduced, and the VIP and SS contents were significantly increased; after 2 weeks of treatment, compared with the model group, the mosapride group, high- and medium-dose medicated ointment The SP content in the group was significantly increased, and the VIP and SS contents were significantly reduced. At the same time, compared with the high-dose medicated diet group of the present invention, the SP content of rats in the high-dose medicated diet group was slightly increased, and the VIP and SS contents were slightly reduced. Compared with the high-dose group of the original medicated diet, the SP content of rats in the low-dose medicated diet group of the present invention was slightly increased, and the VIP and SS contents were slightly reduced.

Table 5 Comparison of SP, VIP and SS expression in serum of STC rats in each group

Group SP(pg/mL) VIP(pg/mL) SS(pg/mL) normal group 16.01±2.21 93.51±11.96 52.93±8.12 model group 6.12±1.10▲ 185.29±20.15▲ 137.65±15.61▲ Original medicinal diet high dose group 11.33±1.25* 126.7±16.84* 72.24±9.43* Original medicated diet low-dose group 8.56±1.03* 153.2±18.53* 112.52±11.37* Medicinal diet high-dose group of the present invention 14.31±1.35* 105.31±15.14* 65.21±9.81* Medicinal diet low-dose group of the present invention 10.12±1.05* 119.32±15.62* 78.51±12.47* Mosapride group 11.62±1.73* 136.3±15.85* 118.32±14.32*

Through drug efficacy experiments, it was found that after 2 weeks of medicated diet treatment, the constipation of STC rats was significantly improved, and the intestinal peristalsis function was enhanced. Both medicated diets could significantly increase the SP content in the blood, reduce the VIP and SS content, and reduce the intestinal motility of the rats. tissue NO, cGMP, and PKG expression, thereby regulating the gastrointestinal function of rats, promoting intestinal peristalsis, and improving constipation; the medicated diet group of the present invention is better than the original medicated diet group.

It is easy for those skilled in the art to understand that the above are only examples of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (10)

1. A kind of traditional Chinese medicinal diet for improving constipation, characterized in that the medicines in the traditional Chinese medicinal diet for improving constipation include almonds, bergamot, platycodon, malt, yam, hawthorn, Gallus gallus gallus gallinae, Yu Liren, perilla seeds, hemp seeds, Psyllium husk and okra powder are used as active ingredients. 2. The traditional Chinese medicinal diet for improving constipation according to claim 1, characterized in that the medicines in the traditional Chinese medicinal diet for improving constipation include 6-18 parts by weight of almonds, 6-18 parts of bergamot, and 15-45 parts of yam. 6-18 parts of hawthorn, 6-18 parts of Gallus gallus gallus L., 6-18 parts of Platycodon grandiflorum, 6-18 parts of malt, 2-18 parts of Yuliren, 2-18 parts of perilla seeds, 2-18 parts of hemp seeds, 1-45 parts of plantain husk powder and 1-18 parts of okra powder. 3. The traditional Chinese medicinal diet for improving constipation according to claim 1, characterized in that the medicines in the traditional Chinese medicinal diet for improving constipation include 6-10 parts by weight of almonds, 6-10 parts of bergamot, and 15-25 parts of yam. 6-10 parts of hawthorn, 6-10 parts of Gallus gallus gallus L., 6-10 parts of platycodon, 6-10 parts of malt, 2-6 parts of Yuliren, 2-6 parts of perilla seeds, 2-6 parts of hemp seeds, 1-6 parts of psyllium husk powder and 1-6 parts of okra powder. 4. The Chinese medicinal diet for improving constipation according to claim 1, characterized in that the Chinese medicinal diet for improving constipation is biscuits. 5. The traditional Chinese medicinal diet for improving constipation according to claim 1, characterized in that the content of active ingredients in the traditional Chinese medicinal diet for improving constipation is 8-30%. 6. The traditional Chinese medicinal diet for improving constipation according to claim 1, characterized in that the traditional Chinese medicinal diet for improving constipation contains 6-18 parts by weight of almonds, 6-18 parts of bergamot, and 15-45 parts of yam. , 6-18 parts of hawthorn, 6-18 parts of Gallus gallus gallus L., 6-18 parts of platycodon, 6-18 parts of malt, 2-18 parts of Yuliren, 2-18 parts of perilla seeds, 2-18 parts of hemp seeds, round 1-45 parts of psyllium husk powder, 1-18 parts of okra powder, 550-660 parts of flour. 7. The preparation method of the traditional Chinese medicinal diet for improving constipation according to any one of claims 1-6, characterized in that the method comprises the following steps: (1) Prepare medicinal powder: ultrafinely crush almonds, bergamot, yam, hawthorn, Gallus gallus gallus L., Platycodon grandiflorum, malt, plum kernels, perilla seeds, and hemp seeds, and then mix with plantain husk powder and okra powder. well mixed; (2) Mix flour and dough: Add water, palm oil, and white sugar to the powder in sequence, stir, add flour, and mix until there is no dry powder and the dough has no gluten; (3) Forming: Use molds to make biscuit blanks of various shapes; (4) Baking: control the temperature for baking; (5) Oil spray: spray palm oil evenly; (6) Cooling and finishing: After baking, the biscuits are cooled to room temperature and transferred to the packaging room; (7) Packaging. 8. The preparation method of traditional Chinese medicine for improving constipation according to claim 7, characterized in that, in step (1), the fineness is 200-400 mesh after ultrafine grinding. 9. The preparation method of traditional Chinese medicine for improving constipation according to claim 7, characterized in that in the step (4), the temperature is controlled to 170-260°C for upper heat and 160-240°C for lower heat. 10. The preparation method of Chinese herbal medicine for improving constipation according to claim 7, characterized in that the amount control standard of oil spraying in step (5) is: weigh 10 biscuits before and after spraying, and the weight is increased by 10 -20%, the fuel injection amount meets the standard requirements.