CN116948800A - A gastrointestinal flora sampling device - Google Patents
A gastrointestinal flora sampling device Download PDFInfo
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- CN116948800A CN116948800A CN202311210308.4A CN202311210308A CN116948800A CN 116948800 A CN116948800 A CN 116948800A CN 202311210308 A CN202311210308 A CN 202311210308A CN 116948800 A CN116948800 A CN 116948800A
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- 238000005070 sampling Methods 0.000 title claims abstract description 71
- 230000002496 gastric effect Effects 0.000 title claims abstract description 26
- 230000001954 sterilising effect Effects 0.000 claims abstract description 60
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 60
- 239000011324 bead Substances 0.000 claims abstract description 40
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 19
- 239000004626 polylactic acid Substances 0.000 claims abstract description 19
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000011521 glass Substances 0.000 claims abstract description 14
- 239000004155 Chlorine dioxide Substances 0.000 claims abstract description 9
- 235000019398 chlorine dioxide Nutrition 0.000 claims abstract description 9
- 239000000523 sample Substances 0.000 claims description 72
- 239000002775 capsule Substances 0.000 claims description 16
- 238000002347 injection Methods 0.000 claims description 12
- 239000007924 injection Substances 0.000 claims description 12
- 238000001125 extrusion Methods 0.000 claims description 11
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims 13
- 235000017491 Bambusa tulda Nutrition 0.000 claims 13
- 241001330002 Bambuseae Species 0.000 claims 13
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims 13
- 239000011425 bamboo Substances 0.000 claims 13
- 238000000926 separation method Methods 0.000 claims 4
- 206010040007 Sense of oppression Diseases 0.000 claims 1
- 238000009434 installation Methods 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- 230000006835 compression Effects 0.000 abstract description 9
- 238000007906 compression Methods 0.000 abstract description 9
- 230000001580 bacterial effect Effects 0.000 abstract description 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract description 6
- 239000002360 explosive Substances 0.000 abstract description 5
- 238000012360 testing method Methods 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 5
- 239000001569 carbon dioxide Substances 0.000 abstract description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract description 3
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 abstract description 3
- 244000005700 microbiome Species 0.000 abstract description 3
- 238000012545 processing Methods 0.000 abstract description 2
- 239000002245 particle Substances 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 18
- 238000000034 method Methods 0.000 description 12
- 238000010586 diagram Methods 0.000 description 8
- 238000011109 contamination Methods 0.000 description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000012535 impurity Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000004880 explosion Methods 0.000 description 2
- 230000002550 fecal effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000007665 sagging Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000002052 colonoscopy Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/38—Caps; Covers; Plugs; Pouring means
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- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
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Abstract
本发明公开了一种胃肠道菌群取样装置,本发明涉及菌群取样技术领域,包括把手筒,所述把手筒的左端螺纹安装有中央接筒,所述中央接筒的左端螺纹安装有一次性灭菌套筒,整体呈透明状。该胃肠道菌群取样装置,可借助顶珠在惯性作用下垂之后,被触发弹簧向上弹动时,精准撞击压迫珠来实现对薄玻璃爆珠的快速击碎,以此来释放出内部的低浓度的二氧化氯,来自动实现对一次性灭菌套筒内部的快速杀菌消毒,通过利用聚乳酸挖勺自身良好的生物可降解性,使用后能被自然界中微生物完全降解,最终生成二氧化碳和水,不污染环境的同时,还不污染样本的菌群,减少单独处理聚乳酸挖勺的步骤,提高取样以及检测样本菌群情况的效率。
The invention discloses a gastrointestinal flora sampling device. The invention relates to the technical field of flora sampling and includes a handle barrel. The left end of the handle barrel is threaded with a central socket. The left end of the central socket is threaded with a thread. Disposable sterilization sleeve, completely transparent. This gastrointestinal flora sampling device can accurately impact the compression beads after the top beads sag due to inertia and are bounced upward by the trigger spring to achieve rapid crushing of thin glass explosive beads, thereby releasing the low-temperature particles inside. concentration of chlorine dioxide to automatically achieve rapid sterilization and disinfection of the interior of the disposable sterilization sleeve. By utilizing the good biodegradability of the polylactic acid scoop, it can be completely degraded by microorganisms in nature after use, ultimately generating carbon dioxide and Water does not pollute the environment and does not contaminate the bacterial flora of the sample. It reduces the steps of separately processing polylactic acid scoops and improves the efficiency of sampling and testing the bacterial flora of the sample.
Description
技术领域Technical field
本发明涉及菌群取样技术领域,具体为一种胃肠道菌群取样装置。The present invention relates to the technical field of flora sampling, specifically a gastrointestinal flora sampling device.
背景技术Background technique
目前胃肠道菌群取样方法主要有两种:非侵入性采样和侵入性采样,非侵入性采样:这种方法适用于一般的菌群研究;常见的非侵入性采样方法包括:粪便样本采集:通过收集个体的新鲜粪便样本进行分析,这种方法简单易行,且对个体没有伤害,能够获得较为全面的肠道菌群信息;电子便盆采样:通过使用带有集尿杯的电子便盆,可以收集到较为纯净的粪便样本;侵入性采样:这种方法适用于一些特殊的菌群研究,常见的侵入性采样方法包括:结肠镜取样和小肠穿刺;然而无论是哪种方法,都需要保持样本在采集后尽快进行处理,并严格遵守消毒和无菌操作的要求,以保证菌群的准确性和可靠性。There are currently two main methods for sampling gastrointestinal flora: non-invasive sampling and invasive sampling. Non-invasive sampling: This method is suitable for general flora research; common non-invasive sampling methods include: fecal sample collection : By collecting fresh stool samples from individuals for analysis, this method is simple and easy to do, does no harm to the individual, and can obtain more comprehensive information on intestinal flora; Electronic bedpan sampling: By using an electronic bedpan with a urine collection cup, Relatively pure fecal samples can be collected; invasive sampling: This method is suitable for some special flora research. Common invasive sampling methods include: colonoscopy sampling and small intestinal puncture; however, no matter which method is used, it is necessary to maintain Samples are processed as soon as possible after collection, and the requirements for disinfection and aseptic operation are strictly followed to ensure the accuracy and reliability of the bacterial flora.
现有的胃肠道菌群取样装置,本身不具备防跌落自消毒保护功能,无法将不慎污染的取样装置或散落的样本进行快速杀菌消毒,来防止样本细菌的扩散或泄露,在取下样本的过程中,往往都需要将样本从挖勺上一点一点刮下,费时费力,还存在样本污染的风险,对样本菌群情况的检测效率低。The existing gastrointestinal flora sampling device itself does not have the function of anti-falling and self-disinfection, and cannot quickly sterilize accidentally contaminated sampling devices or scattered samples to prevent the spread or leakage of sample bacteria. During the sampling process, it is often necessary to scrape the sample off the scoop bit by bit, which is time-consuming and labor-intensive. There is also the risk of sample contamination, and the detection efficiency of the sample flora is low.
发明内容Contents of the invention
为实现以上目的,本发明通过以下技术方案予以实现:一种胃肠道菌群取样装置,包括把手筒,所述把手筒的左端螺纹安装有中央接筒,所述中央接筒的左端螺纹安装有一次性灭菌套筒,整体呈透明状,可方便观察收集在一次性灭菌套筒内部的样本的实时情况,以便于决定对样本的继续使用或灭菌处理,所述一次性灭菌套筒的左端螺纹安装有一次性灭菌封盖,用于对一次性灭菌套筒的左端进行闭合遮挡;In order to achieve the above objects, the present invention is realized through the following technical solutions: a gastrointestinal flora sampling device, including a handle tube, the left end of the handle tube is threadedly installed with a central socket, and the left end of the central socket is threadedly installed There is a disposable sterilization sleeve, which is transparent as a whole. It is convenient to observe the real-time situation of the samples collected inside the disposable sterilization sleeve, so as to decide whether to continue using or sterilizing the samples. The disposable sterilization The left end of the sleeve is threaded with a disposable sterilization cover, which is used to close and block the left end of the disposable sterilization sleeve;
还包括取样总成,该取样总成组装在把手筒的内侧,能够在把手筒内侧左右伸缩运动;It also includes a sampling assembly, which is assembled on the inside of the handle tube and can telescopically move left and right on the inside of the handle tube;
杀菌总成,该杀菌总成安装在中央接筒的内壁上,所述杀菌总成包括安装在把手筒左端内侧的单向注射管,且一端暴露在把手筒的外表面,一端插装在中央接筒的内壁上,并延伸至中央接筒的内腔中。Sterilization assembly, which is installed on the inner wall of the central barrel. The sterilization assembly includes a one-way injection tube installed inside the left end of the handle barrel, with one end exposed on the outer surface of the handle barrel, and the other end inserted in the center. on the inner wall of the adapter and extends into the inner cavity of the central adapter.
优选的,所述把手筒的外表面对称连接有挂耳,且位于远离中央接筒的右端设置,所述把手筒的左端中部固定连接有第一螺纹环,所述把手筒的左端中部还固定连接有第二螺纹环,且笼罩在第一螺纹环的外侧,所述把手筒通过第一螺纹环和第二螺纹环配合与中央接筒螺纹安装。Preferably, a hanging ear is symmetrically connected to the outer surface of the handle barrel and is located at the right end away from the central barrel. A first threaded ring is fixedly connected to the middle part of the left end of the handle barrel, and the middle part of the left end of the handle barrel is also fixed. A second threaded ring is connected and covers the outside of the first threaded ring. The handle tube is threadedly installed with the central socket through the first threaded ring and the second threaded ring.
优选的,所述把手筒的左端开设有中央隔腔,且位于第一螺纹环与第二螺纹环之间开设,保护被抽真空后的把手筒的内腔时刻保持在无菌状态,从而规避细菌在长探杆表面的附着,消除把手筒内腔中细菌通过长探杆对样品的污染隐患。Preferably, a central compartment is provided at the left end of the handle barrel and is located between the first threaded ring and the second threaded ring to protect the inner cavity of the vacuumed handle barrel in a sterile state at all times, thus avoiding the possibility of The attachment of bacteria to the surface of the long probe eliminates the risk of contamination of the sample by bacteria in the inner cavity of the handle tube through the long probe.
优选的,所述把手筒远离中央接筒的一端中部安装有第一转轴,所述中央接筒的右端中部安装有第二转轴,所述第二转轴的内侧嵌合安装有无菌封套,所述无菌封套通过第二转轴与中央接筒旋转安装,所述中央接筒内腔的边棱处设置有倒圆部,减少中央接筒的内腔死角,避免细菌在中央接筒内壁上的大量附着。Preferably, a first rotating shaft is installed in the middle of one end of the handle barrel away from the central receiving barrel, a second rotating shaft is installed in the middle of the right end of the central receiving barrel, and a sterile envelope is fitted and installed on the inside of the second rotating shaft, so The sterile envelope is rotatably installed with the central receiving barrel through the second rotating shaft. The edges of the inner cavity of the central receiving barrel are provided with rounded portions to reduce the dead angle of the inner cavity of the central receiving barrel and prevent bacteria from colonizing the inner wall of the central receiving barrel. Massive attachment.
优选的,所述把手筒的左端安装有真空阀管,且贯穿第二螺纹环并伸入中央隔腔内侧,并且第一螺纹环内壁上与中央隔腔相对应的位置上开设有单向阀孔,用于将把手筒内侧的空气通过中央隔腔和真空阀管的引导,而单向抽出,使得把手筒的内侧始终处于真空状态,所述把手筒的外表面上固定连接有平衡板,且背离真空阀管的一侧设置,能够使得把手筒水平摆放在试验台面上,防止取样装置整体出现翻滚或晃动的现象。Preferably, a vacuum valve tube is installed on the left end of the handle barrel and penetrates the second threaded ring and extends into the inside of the central compartment, and a one-way valve is provided on the inner wall of the first threaded ring at a position corresponding to the central compartment. The hole is used to guide the air inside the handle tube through the central compartment and the vacuum valve tube and extract it in one direction so that the inside of the handle tube is always in a vacuum state. A balance plate is fixedly connected to the outer surface of the handle tube. And the side facing away from the vacuum valve tube allows the handle tube to be placed horizontally on the test bench to prevent the entire sampling device from rolling or shaking.
优选的,所述取样总成包括通过第一转轴与把手筒旋转安装的长探杆,所述长探杆的外表面上固定安装有圆盘,且靠近第一转轴设置,所述长探杆的外表面上套装有挤压弹簧,所述长探杆的外表面上套装有挡板,所述挤压弹簧安装在圆盘与挡板之间,且一端与圆盘固定连接,另一端与挡板固定连接,所述挡板嵌合安装在把手筒的内壁中,所述长探杆通过挤压弹簧和挡板配合与把手筒弹动安装。Preferably, the sampling assembly includes a long probe rod that is rotatably installed through a first rotating shaft and a handle barrel. A disc is fixedly mounted on the outer surface of the long probe rod and is disposed close to the first rotating shaft. The long probe rod An extrusion spring is set on the outer surface of the long probe rod, and a baffle is set on the outer surface of the long probe rod. The extrusion spring is installed between the disc and the baffle, and one end is fixedly connected to the disc, and the other end is connected to the disc. The baffle is fixedly connected, and the baffle is fitted and installed in the inner wall of the handle tube. The long probe rod is elastically installed with the handle tube through the extrusion spring and the baffle.
优选的,所述长探杆的左端中部固定连接有倒钩,且向右倾斜设置,所述长探杆的外表面上安装有环状胶囊,所述长探杆的左端安装有聚乳酸挖勺,所述聚乳酸挖勺通过倒钩与长探杆扣合安装,所述聚乳酸挖勺远离长探杆的一端边侧对称连接有凸刺,能够对包裹在无菌袋中的样品,进行辅助破袋取样。Preferably, the middle part of the left end of the long probe rod is fixedly connected with a barb and tilted to the right. An annular capsule is installed on the outer surface of the long probe rod. The left end of the long probe rod is equipped with a polylactic acid excavator. Spoon, the polylactic acid scoop is installed by being fastened with the long probe rod through barbs. The end of the polylactic acid scoop away from the long probe rod is symmetrically connected with convex thorns on both sides, which can detect the sample wrapped in the sterile bag. Carry out auxiliary bag breaking sampling.
优选的,所述环状胶囊的左端固定安装有定位环,所述环状胶囊的右端固定安装有延展塞环,所述环状胶囊通过定位环与长探杆组合安装,所述延展塞环能够嵌合安装在第二转轴与无菌封套组装的凹槽中,并利用环状胶囊对第二转轴左端的封装遮挡,提供双重阻菌结构,防止采集样本之后的一次性灭菌套筒,通过长探杆而污染到中央接筒以及把手筒的内腔,减少单独处理聚乳酸挖勺的步骤,提高取样以及检测样本菌群情况的效率。Preferably, the left end of the annular capsule is fixedly installed with a positioning ring, and the right end of the annular capsule is fixedly installed with an extension plug ring. The annular capsule is installed in combination with the positioning ring and the long probe rod, and the extension plug ring It can be fitted and installed in the groove where the second rotating shaft and the sterile envelope are assembled, and the annular capsule is used to shield the left end of the second rotating shaft, providing a double bactericidal structure to prevent the disposable sterilization sleeve after collecting the sample. The long probe rod contaminates the inner cavity of the central barrel and the handle barrel, reducing the steps of separately handling the polylactic acid scoop, and improving the efficiency of sampling and testing the sample flora.
优选的,所述把手筒的内壁面固定连接有引导块,且位于左端设置,单向注射管贯穿引导块的中部设置,用于对单向注射管的中部起到支撑与引导作用,所述单向注射管伸入中央接筒内腔的一端螺纹安装有薄玻璃爆珠,且内部盛装有低浓度的二氧化氯,用于对污染的样本进行杀菌除臭,所述薄玻璃爆珠的外表面中部安装有压迫珠,方便对薄玻璃爆珠进行击碎。Preferably, a guide block is fixedly connected to the inner wall surface of the handle barrel and is located at the left end. The one-way injection pipe is provided through the middle of the guide block to support and guide the middle part of the one-way injection pipe. One end of the one-way injection tube extending into the inner cavity of the central socket is threaded with a thin glass explosive bead, and the interior is filled with low-concentration chlorine dioxide, which is used to sterilize and deodorize contaminated samples. The thin glass explosive beads are There are compression beads installed in the middle of the outer surface to facilitate crushing of thin glass blast beads.
优选的,所述中央接筒的内壁上固定安装有半球体,所述半球体远离中央接筒内壁的一面安装有顶珠,所述顶珠与半球体之间连接有触发弹簧,所述顶珠通过触发弹簧与半球体弹动连接,且顶珠的顶部与压迫珠相对应配合,但不接触,用于在取样装置跌落地面或遭受外力正面冲击时,借助顶珠在惯性作用下垂之后,被触发弹簧向上弹动时,精准撞击压迫珠来实现对薄玻璃爆珠的快速击碎,以此来释放出内部的低浓度的二氧化氯,来自动实现对一次性灭菌套筒内部的快速杀菌消毒。Preferably, a hemisphere is fixedly installed on the inner wall of the central socket, and a top bead is installed on the side of the hemisphere away from the inner wall of the central socket. A trigger spring is connected between the top bead and the hemisphere. The top bead is triggered by The spring is elastically connected to the hemisphere, and the top of the top bead matches the compression bead, but does not contact. It is used to trigger the spring to bounce upward after the top bead sags due to inertia when the sampling device falls to the ground or suffers a frontal impact from an external force. When moving, the compression beads are accurately impacted to quickly crush the thin glass beads, thereby releasing the low concentration of chlorine dioxide inside to automatically achieve rapid sterilization and disinfection of the interior of the disposable sterilization sleeve.
本发明提供了一种胃肠道菌群取样装置,具备以下有益效果:The invention provides a gastrointestinal flora sampling device, which has the following beneficial effects:
一、该胃肠道菌群取样装置,当取样装置跌落地面或遭受外力正面冲击时,可借助顶珠在惯性作用下垂之后,被触发弹簧向上弹动时,精准撞击压迫珠来实现对薄玻璃爆珠的快速击碎,以此来释放出内部的低浓度的二氧化氯,来自动实现对一次性灭菌套筒内部的快速杀菌消毒,使得该取样装置具备防跌落自消毒保护功能。1. This gastrointestinal flora sampling device, when the sampling device falls to the ground or suffers a frontal impact from an external force, can use the top beads to accurately impact the compression beads after sagging due to inertia and being bounced upward by the trigger spring to achieve explosion of thin glass. The beads are quickly crushed to release the low-concentration chlorine dioxide inside, which automatically realizes rapid sterilization and disinfection of the interior of the disposable sterilization sleeve, making the sampling device equipped with anti-fall and self-disinfection protection functions.
二、该胃肠道菌群取样装置,通过利用聚乳酸挖勺自身良好的生物可降解性,使用后能被自然界中微生物完全降解,最终生成二氧化碳和水,不污染环境的同时,还不污染样本的菌群,减少单独处理聚乳酸挖勺的步骤,提高取样以及检测样本菌群情况的效率。2. This gastrointestinal flora sampling device takes advantage of the good biodegradability of the polylactic acid scoop itself. After use, it can be completely degraded by microorganisms in nature, eventually generating carbon dioxide and water, without polluting the environment. The bacterial flora of the sample reduces the need for separate processing of polylactic acid scoops and improves the efficiency of sampling and testing the bacterial flora of the sample.
三、该胃肠道菌群取样装置,通过延展塞环能够嵌合安装在第二转轴与无菌封套组装的凹槽中,并利用环状胶囊对第二转轴左端的封装遮挡,结合无菌封套对细菌的有效阻挡,来共同提供双重阻菌结构,防止采集样本之后的一次性灭菌套筒,通过长探杆而污染到中央接筒以及把手筒的内腔,为更换新的一次性灭菌套筒和一次性灭菌封盖之后,实现把手筒和中央接筒的连续安全使用,保障前一次的取样过程不会干扰下一次的取样结果,实现该取样装置主体的循环利用,能够将污染最为严重的部位直接丢弃,而将操作部位进行重复利用,减少资源浪费的同时,使得医护人员对于取样装置的使用越发得心应手。3. The gastrointestinal flora sampling device can be installed in the groove of the second rotating shaft and the sterile envelope by extending the stopper ring, and uses the annular capsule to cover the left end of the second rotating shaft, combined with the sterile The envelope effectively blocks bacteria and jointly provides a double bacteriostatic structure to prevent the disposable sterilization sleeve after collecting the sample from contaminating the inner cavity of the central receiving sleeve and the handle sleeve through the long probe rod, making it easier to replace the disposable sterilization sleeve with a new one. After the sterilization sleeve and the disposable sterilization cap are sealed, the handle barrel and the central adapter can be used continuously and safely to ensure that the previous sampling process will not interfere with the next sampling result, and to realize the recycling of the main body of the sampling device, which can The most contaminated parts are directly discarded, and the operating parts are reused, which not only reduces the waste of resources, but also makes the medical staff more comfortable in using the sampling device.
四、该胃肠道菌群取样装置,通过利用中央隔腔作为创造把手筒内腔为无菌环境的缓冲隔离带,用于将把手筒内侧抽出的细菌隔离在中央隔腔内侧,防止通过真空阀管对把手筒内腔进行抽真空时,少数细菌或杂质残留在把手筒内腔中,来保护被抽真空后的把手筒的内腔,时刻保持在无菌状态,从而规避细菌在长探杆表面的附着,消除把手筒内腔中细菌通过长探杆对样品的污染隐患。4. This gastrointestinal flora sampling device uses the central compartment as a buffer isolation zone to create a sterile environment in the inner cavity of the handle barrel. It is used to isolate the bacteria extracted from the inside of the handle barrel inside the central compartment to prevent the passage of vacuum. When the valve tube evacuates the inner cavity of the handle barrel, a small number of bacteria or impurities remain in the inner cavity of the handle barrel to protect the vacuumed inner cavity of the handle barrel and keep it in a sterile state at all times, thus avoiding the possibility of bacteria probing for a long time. The attachment to the surface of the rod eliminates the risk of contamination of the sample by bacteria in the inner cavity of the handle tube through the long probe rod.
五、该胃肠道菌群取样装置,通过单向注射管,额外向一次性灭菌套筒内部持续注入大量的低浓度的二氧化氯,来确保对一次性灭菌套筒内部过量样本的充分杀菌消毒处理,防止跌落或受外力冲击之后而污染一次性灭菌套筒内壁的样本,再对工作环境进行污染,将样本中的细菌提前灭除在一次性灭菌套筒内部,方便更换新的一次性灭菌套筒和一次性灭菌封盖;同时通过杀菌消毒水对中央接筒内腔进行简单冲洗,即可再次进行下一次取样操作。5. This gastrointestinal flora sampling device continuously injects a large amount of low-concentration chlorine dioxide into the disposable sterilization sleeve through a one-way injection tube to ensure the detection of excess samples inside the disposable sterilization sleeve. Fully sterilized and disinfected to prevent samples from contaminating the inner wall of the disposable sterilization sleeve after being dropped or impacted by external forces, and then contaminating the working environment. Bacteria in the sample are eliminated in advance inside the disposable sterilization sleeve to facilitate replacement. New disposable sterilization sleeve and disposable sterilization cover; at the same time, simply flush the inner cavity of the central receiving tube with sterilizing water to start the next sampling operation again.
附图说明Description of the drawings
图1为本发明一种胃肠道菌群取样装置的拆解结构示意图;Figure 1 is a schematic diagram of the disassembled structure of a gastrointestinal flora sampling device according to the present invention;
图2为本发明把手筒的内部结构示意图;Figure 2 is a schematic diagram of the internal structure of the handle barrel of the present invention;
图3为本发明一次性灭菌套筒通过中央接筒与把手筒的组装结构示意图;Figure 3 is a schematic diagram of the assembly structure of the disposable sterilization sleeve of the present invention through the central socket and the handle sleeve;
图4为本发明一次性灭菌套筒的内部结构示意图;Figure 4 is a schematic diagram of the internal structure of the disposable sterilization sleeve of the present invention;
图5为本发明中央接筒与把手筒的局部组装结构示意图;Figure 5 is a schematic diagram of the partial assembly structure of the central barrel and the handle barrel of the present invention;
图6为本发明聚乳酸挖勺与长探杆的拆解结构示意图;Figure 6 is a schematic diagram of the disassembled structure of the polylactic acid scoop and long probe of the present invention;
图7为本发明把手筒的底部结构示意图;Figure 7 is a schematic diagram of the bottom structure of the handle barrel of the present invention;
图8为本发明一种胃肠道菌群取样装置的外部结构示意图。Figure 8 is a schematic diagram of the external structure of a gastrointestinal flora sampling device according to the present invention.
图中:1、把手筒;2、取样总成;21、长探杆;22、圆盘;23、挤压弹簧;24、挡板;25、倒钩;26、环状胶囊;27、聚乳酸挖勺;28、凸刺;29、定位环;210、延展塞环;3、中央接筒;4、杀菌总成;41、单向注射管;42、引导块;43、薄玻璃爆珠;44、压迫珠;45、半球体;46、顶珠;47、触发弹簧;5、一次性灭菌套筒;6、一次性灭菌封盖;7、挂耳;8、第一螺纹环;9、第二螺纹环;10、中央隔腔;11、第一转轴;12、第二转轴;13、无菌封套;14、倒圆部;15、真空阀管;16、平衡板。In the picture: 1. Handle barrel; 2. Sampling assembly; 21. Long probe; 22. Disc; 23. Squeeze spring; 24. Baffle; 25. Barb; 26. Ring capsule; 27. Polymer Lactic acid scoop; 28. Protruding thorn; 29. Positioning ring; 210. Extended plug ring; 3. Central adapter; 4. Sterilization assembly; 41. One-way injection tube; 42. Guide block; 43. Thin glass explosion beads ; 44. Compression bead; 45. Hemisphere; 46. Top bead; 47. Trigger spring; 5. Disposable sterilization sleeve; 6. Disposable sterilization cap; 7. Hanging ear; 8. First threaded ring; 9. Second threaded ring; 10. Central compartment; 11. First rotating shaft; 12. Second rotating shaft; 13. Sterile envelope; 14. Rounded portion; 15. Vacuum valve tube; 16. Balance plate.
具体实施方式Detailed ways
下面结合附图和具体实施方式对本发明作进一步详细的说明。本发明的实施例是为了示例和描述起见而给出的,而并不是无遗漏的或者将本发明限于所公开的形式。很多修改和变化对于本领域的普通技术人员而言是显而易见的。选择和描述实施例是为了更好说明本发明的原理和实际应用,并且使本领域的普通技术人员能够理解本发明从而设计适于特定用途的带有各种修改的各种实施例。The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments. The embodiments of the present invention are presented for the purposes of illustration and description, and are not intended to be exhaustive or to limit the invention to the form disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiment was chosen and described in order to best explain the principles of the invention and the practical application, and to enable others of ordinary skill in the art to understand the invention and design various embodiments with various modifications as are suited to the particular use contemplated.
第一实施例,如图1至图8所示,本发明提供一种技术方案:一种胃肠道菌群取样装置,包括把手筒1,把手筒1的左端螺纹安装有中央接筒3,中央接筒3的左端螺纹安装有一次性灭菌套筒5,一次性灭菌套筒5的左端螺纹安装有一次性灭菌封盖6,用于对一次性灭菌套筒5的左端进行闭合遮挡;First Embodiment, as shown in Figures 1 to 8, the present invention provides a technical solution: a gastrointestinal flora sampling device, including a handle barrel 1, and a central socket 3 is threadedly installed on the left end of the handle barrel 1. A disposable sterilization sleeve 5 is installed on the thread at the left end of the central socket 3, and a disposable sterilization cover 6 is installed on the thread at the left end of the disposable sterilization sleeve 5, which is used to perform sterilization on the left end of the disposable sterilization sleeve 5. Close occlusion;
还包括取样总成2,该取样总成2组装在把手筒1的内侧,能够在把手筒1内侧左右伸缩运动;It also includes a sampling assembly 2, which is assembled inside the handle tube 1 and can telescopically move left and right inside the handle tube 1;
杀菌总成4,该杀菌总成4安装在中央接筒3的内壁上,杀菌总成4包括安装在把手筒1左端内侧的单向注射管41,且一端暴露在把手筒1的外表面,一端插装在中央接筒3的内壁上,并延伸至中央接筒3的内腔中。Sterilization assembly 4. The sterilization assembly 4 is installed on the inner wall of the central socket 3. The sterilization assembly 4 includes a one-way injection tube 41 installed inside the left end of the handle barrel 1, and one end is exposed on the outer surface of the handle barrel 1. One end is inserted into the inner wall of the central socket 3 and extends into the inner cavity of the central socket 3 .
把手筒1的外表面对称连接有挂耳7,且位于远离中央接筒3的右端设置,把手筒1的左端中部固定连接有第一螺纹环8,把手筒1的左端中部还固定连接有第二螺纹环9,且笼罩在第一螺纹环8的外侧,把手筒1通过第一螺纹环8和第二螺纹环9配合与中央接筒3螺纹安装。A hanging ear 7 is symmetrically connected to the outer surface of the handle tube 1 and is located at the right end away from the central socket 3. A first threaded ring 8 is fixedly connected to the middle part of the left end of the handle tube 1, and a third threaded ring 8 is fixedly connected to the middle part of the left end of the handle tube 1. Two threaded rings 9 cover the outside of the first threaded ring 8. The handle tube 1 is threadedly installed with the central socket 3 through the first threaded ring 8 and the second threaded ring 9.
把手筒1的左端开设有中央隔腔10,且位于第一螺纹环8与第二螺纹环9之间开设,防止通过真空阀管15对把手筒1内腔进行抽真空时,少数细菌或杂质残留在把手筒1内腔中。A central compartment 10 is provided at the left end of the handle barrel 1 and is located between the first threaded ring 8 and the second threaded ring 9 to prevent a small number of bacteria or impurities from being released when the inner cavity of the handle barrel 1 is evacuated through the vacuum valve tube 15 remain in the inner cavity of the handle barrel 1.
把手筒1远离中央接筒3的一端中部安装有第一转轴11,中央接筒3的右端中部安装有第二转轴12,第二转轴12的内侧嵌合安装有无菌封套13,无菌封套13通过第二转轴12与中央接筒3旋转安装,中央接筒3内腔的边棱处设置有倒圆部14,减少中央接筒3的内腔死角,避免细菌在中央接筒3内壁上的大量附着。A first rotating shaft 11 is installed in the middle of the end of the handle barrel 1 away from the central receiving barrel 3. A second rotating shaft 12 is installed in the middle of the right end of the central receiving barrel 3. A sterile envelope 13 is installed on the inner side of the second rotating shaft 12. The sterile envelope 13. The second rotating shaft 12 is rotated with the central adapter 3. A rounded portion 14 is provided at the edge of the inner cavity of the central adapter 3 to reduce the dead space in the inner cavity of the central adapter 3 and prevent bacteria from growing on the inner wall of the central adapter 3. A lot of attachment.
把手筒1的左端安装有真空阀管15,且贯穿第二螺纹环9并伸入中央隔腔10内侧,并且第一螺纹环8内壁上与中央隔腔10相对应的位置上开设有单向阀孔,用于将把手筒1内侧的空气通过中央隔腔10和真空阀管15的引导,而单向抽出,使得把手筒1的内侧始终处于真空状态,把手筒1的外表面上固定连接有平衡板16,且背离真空阀管15的一侧设置。A vacuum valve tube 15 is installed on the left end of the handle barrel 1, and penetrates the second threaded ring 9 and extends into the inside of the central compartment 10, and a one-way valve is provided on the inner wall of the first threaded ring 8 at a position corresponding to the central compartment 10. The valve hole is used to guide the air inside the handle barrel 1 through the central compartment 10 and the vacuum valve tube 15 and extract it in one direction, so that the inside of the handle barrel 1 is always in a vacuum state, and the outer surface of the handle barrel 1 is fixedly connected There is a balance plate 16, and it is arranged on the side facing away from the vacuum valve tube 15.
使用时,通过扭转掉一次性灭菌封盖6,手指扣压挂耳7,按压长探杆21,利用聚乳酸挖勺27挖取适量样本收回一次性灭菌套筒5内单独存储,并再次封装上一次性灭菌封盖6,待到达无菌操作环境之后,打开一次性灭菌封盖6,将聚乳酸挖勺27直接顺应倒钩25的倾斜方向掰折,即可将聚乳酸挖勺27连同样本一同取下,无需手部接触,单手即可操作,杜绝对样本菌群的污染,以及避免过多的仪器接触,减少清洗和器材的损耗。When in use, twist off the disposable sterilization cover 6, press the hanging ear 7 with your fingers, press the long probe 21, use the polylactic acid scoop 27 to dig out an appropriate amount of sample, take it back into the disposable sterilization sleeve 5, store it separately, and store it again The disposable sterilization cover 6 is sealed. After reaching the sterile operating environment, the disposable sterilization cover 6 is opened, and the polylactic acid scoop 27 is directly bent in the inclined direction of the barb 25 to scoop out the polylactic acid. The spoon 27 is removed together with the sample, no hand contact is required, and it can be operated with one hand, thereby eliminating contamination of the sample flora, avoiding excessive instrument contact, and reducing cleaning and equipment losses.
利用中央隔腔10作为创造把手筒1内腔为无菌环境的缓冲隔离带,用于将把手筒1内侧抽出的细菌隔离在中央隔腔10内侧,防止通过真空阀管15对把手筒1内腔进行抽真空时,少数细菌或杂质残留在把手筒1内腔中,来保护被抽真空后的把手筒1的内腔,时刻保持在无菌状态,从而规避细菌在长探杆21表面的附着,消除把手筒1内腔中细菌通过长探杆21对样品的污染隐患。The central compartment 10 is used as a buffer isolation zone to create a sterile environment in the inner cavity of the handle barrel 1. It is used to isolate the bacteria extracted from the inside of the handle barrel 1 inside the central compartment 10 and prevent the inside of the handle barrel 1 from being exposed through the vacuum valve tube 15. When the cavity is evacuated, a small number of bacteria or impurities remain in the inner cavity of the handle barrel 1 to protect the vacuumed inner cavity of the handle barrel 1 and keep it in a sterile state at all times, thereby avoiding the presence of bacteria on the surface of the long probe rod 21 Attachment eliminates the potential risk of contamination of the sample by bacteria in the inner cavity of the handle tube 1 through the long probe rod 21.
第二实施例,在实施例一的基础上,请参阅图2至图6所示,取样总成2包括通过第一转轴11与把手筒1旋转安装的长探杆21,长探杆21的外表面上固定安装有圆盘22,且靠近第一转轴11设置,长探杆21的外表面上套装有挤压弹簧23,长探杆21的外表面上套装有挡板24,挤压弹簧23安装在圆盘22与挡板24之间,且一端与圆盘22固定连接,另一端与挡板24固定连接,挡板24嵌合安装在把手筒1的内壁中,长探杆21通过挤压弹簧23和挡板24配合与把手筒1弹动安装。The second embodiment, based on the first embodiment, please refer to Figures 2 to 6. The sampling assembly 2 includes a long probe rod 21 that is rotatably installed through the first rotating shaft 11 and the handle barrel 1. The long probe rod 21 has A disc 22 is fixedly installed on the outer surface and is arranged close to the first rotating shaft 11. An extrusion spring 23 is set on the outer surface of the long probe rod 21. A baffle 24 is set on the outer surface of the long probe rod 21. The extrusion spring 23 is installed between the disc 22 and the baffle 24, and one end is fixedly connected to the disc 22, and the other end is fixedly connected to the baffle 24. The baffle 24 is fitted and installed in the inner wall of the handle tube 1, and the long probe rod 21 passes through The extrusion spring 23 and the baffle 24 cooperate with the handle barrel 1 and are mounted elastically.
长探杆21的左端中部固定连接有倒钩25,且向右倾斜设置,长探杆21的外表面上安装有环状胶囊26,长探杆21的左端安装有聚乳酸挖勺27,聚乳酸挖勺27通过倒钩25与长探杆21扣合安装,聚乳酸挖勺27远离长探杆21的一端边侧对称连接有凸刺28,能够对包裹在无菌袋中的样品,进行辅助破袋取样。The middle part of the left end of the long probe rod 21 is fixedly connected with a barb 25 and is tilted to the right. An annular capsule 26 is installed on the outer surface of the long probe rod 21. A polylactic acid scoop 27 is installed on the left end of the long probe rod 21. The lactic acid scoop 27 is fastened and installed with the long probe rod 21 through the barb 25. The end of the polylactic acid scoop 27 away from the long probe rod 21 is symmetrically connected with protrusions 28 on both sides, so that the sample wrapped in the sterile bag can be processed. Assist bag breaking sampling.
环状胶囊26的左端固定安装有定位环29,环状胶囊26的右端固定安装有延展塞环210,环状胶囊26通过定位环29与长探杆21组合安装,保障前一次的取样过程不会干扰下一次的取样结果。The left end of the annular capsule 26 is fixedly installed with a positioning ring 29, and the right end of the annular capsule 26 is fixedly installed with an extension plug ring 210. The annular capsule 26 is installed in combination with the positioning ring 29 and the long probe rod 21 to ensure that the previous sampling process is not interrupted. It will interfere with the next sampling results.
使用时,通过延展塞环210能够嵌合安装在第二转轴12与无菌封套13组装的凹槽中,并利用环状胶囊26对第二转轴12左端的封装遮挡,结合无菌封套13对细菌的有效阻挡,来共同提供双重阻菌结构,防止采集样本之后的一次性灭菌套筒5,通过长探杆21而污染到中央接筒3以及把手筒1的内腔,为更换新的一次性灭菌套筒5和一次性灭菌封盖6之后,实现把手筒1和中央接筒3的连续安全使用,保障前一次的取样过程不会干扰下一次的取样结果,实现该取样装置主体的循环利用,能够将污染最为严重的部位直接丢弃,而将操作部位进行重复利用,减少资源浪费的同时,使得医护人员对于取样装置的使用越发得心应手;When in use, the plug ring 210 can be fitted and installed in the groove where the second rotating shaft 12 and the sterile envelope 13 are assembled by extending the plug ring 210, and the annular capsule 26 is used to seal the left end of the second rotating shaft 12, and combined with the sterile envelope 13, the The effective blocking of bacteria jointly provides a double bactericidal structure to prevent the disposable sterilization sleeve 5 after collecting the sample from contaminating the inner cavity of the central receiving sleeve 3 and the handle sleeve 1 through the long probe 21. In order to replace the new one After the disposable sterilization sleeve 5 and the disposable sterilization cap 6, the continuous safe use of the handle barrel 1 and the central receiving barrel 3 is realized, ensuring that the previous sampling process will not interfere with the next sampling result, and the sampling device is realized The recycling of the main body can directly discard the most contaminated parts, and reuse the operating parts, which not only reduces the waste of resources, but also makes the medical staff more comfortable in using the sampling device;
通过利用聚乳酸挖勺27自身良好的生物可降解性,使用后能被自然界中微生物完全降解,最终生成二氧化碳和水,不污染环境的同时,还不污染样本的菌群,减少单独处理聚乳酸挖勺27的步骤,提高取样以及检测样本菌群情况的效率。By taking advantage of the good biodegradability of polylactic acid scoop 27, it can be completely degraded by microorganisms in nature after use, eventually generating carbon dioxide and water. It does not pollute the environment and does not contaminate the bacterial flora of the sample, reducing the need to handle polylactic acid alone. Step 27 of scooping can improve the efficiency of sampling and testing the bacterial flora of the sample.
第三实施例,在实施例一、二的基础上,请参阅图4和图5所示,把手筒1的内壁面固定连接有引导块42,且位于左端设置,单向注射管41贯穿引导块42的中部设置,用于对单向注射管41的中部起到支撑与引导作用,单向注射管41伸入中央接筒3内腔的一端螺纹安装有薄玻璃爆珠43,且内部盛装有低浓度的二氧化氯,用于对污染的样本进行杀菌除臭,薄玻璃爆珠43的外表面中部安装有压迫珠44,方便对薄玻璃爆珠43进行击碎。The third embodiment is based on the first and second embodiments. Please refer to Figures 4 and 5. A guide block 42 is fixedly connected to the inner wall of the handle barrel 1 and is located at the left end. A one-way injection tube 41 passes through the guide block 42. The middle part of the block 42 is provided to support and guide the middle part of the one-way injection tube 41. One end of the one-way injection tube 41 that extends into the inner cavity of the central socket 3 is threaded with a thin glass popping bead 43, and is filled inside. There is a low concentration of chlorine dioxide, which is used to sterilize and deodorize contaminated samples. A compression bead 44 is installed in the middle of the outer surface of the thin glass exploding beads 43 to facilitate crushing of the thin glass exploding beads 43.
中央接筒3的内壁上固定安装有半球体45,半球体45远离中央接筒3内壁的一面安装有顶珠46,顶珠46与半球体45之间连接有触发弹簧47,顶珠46通过触发弹簧47与半球体45弹动连接,且顶珠46的顶部与压迫珠44相对应配合,但不接触。A hemisphere 45 is fixedly installed on the inner wall of the central socket 3. A top bead 46 is installed on the side of the hemisphere 45 away from the inner wall of the central socket 3. A trigger spring 47 is connected between the top bead 46 and the hemisphere 45. The top bead 46 passes through the trigger spring 47. It is elastically connected to the hemispherical body 45, and the top of the top bead 46 corresponds to the compression bead 44, but does not contact.
使用时,当取样装置跌落地面或遭受外力正面冲击时,可借助顶珠46在惯性作用下垂之后,被触发弹簧47向上弹动时,精准撞击压迫珠44来实现对薄玻璃爆珠43的快速击碎,以此来释放出内部的低浓度的二氧化氯,来自动实现对一次性灭菌套筒5内部的快速杀菌消毒,使得该取样装置具备防跌落自消毒保护功能;When in use, when the sampling device falls to the ground or suffers a frontal impact from an external force, the top bead 46 can be used to accurately hit the compression bead 44 after sagging due to inertia and being bounced upward by the trigger spring 47 to achieve rapid impact on the thin glass explosive bead 43. Crush, thereby releasing low-concentration chlorine dioxide inside, to automatically realize rapid sterilization and disinfection of the interior of the disposable sterilization sleeve 5, so that the sampling device has the function of anti-falling and self-disinfection protection;
并且通过更换新的薄玻璃爆珠43,即可实现杀菌总成4与把手筒1和中央接筒3之间的再次配合使用,继续发挥该取样装置的自我防跌落保护功能;And by replacing the new thin glass explosive beads 43, the sterilization assembly 4, the handle barrel 1 and the central adapter 3 can be used together again, and the self-anti-fall protection function of the sampling device can continue to be exerted;
并且还能够通过单向注射管41,额外向一次性灭菌套筒5内部持续注入大量的低浓度的二氧化氯,来确保对一次性灭菌套筒5内部过量样本的充分杀菌消毒处理,防止跌落或受外力冲击之后而污染一次性灭菌套筒5内壁的样本,再对工作环境进行污染,将样本中的细菌提前灭除在一次性灭菌套筒5内部,方便更换新的一次性灭菌套筒5和一次性灭菌封盖6;同时通过杀菌消毒水对中央接筒3内腔进行简单冲洗,即可再次进行下一次取样操作。Moreover, a large amount of low-concentration chlorine dioxide can be continuously injected into the interior of the disposable sterilization sleeve 5 through the one-way injection tube 41 to ensure sufficient sterilization and disinfection of excess samples inside the disposable sterilization sleeve 5. Prevent the sample from contaminating the inner wall of the disposable sterilization sleeve 5 after falling or being impacted by external force, and then pollute the working environment, and eliminate the bacteria in the sample in advance inside the disposable sterilization sleeve 5, so as to facilitate the replacement of a new one The disposable sterilizing sleeve 5 and the disposable sterilizing cover 6 are installed; at the same time, the inner cavity of the central receiving barrel 3 is simply rinsed with sterilizing water, and the next sampling operation can be carried out again.
显然,所描述的实施例仅仅是本发明的一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域及相关领域的普通技术人员在没有作出创造性劳动的前提下所获得的所有其他实施例,都应属于本发明保护的范围。本发明中未具体描述和解释说明的结构、装置以及操作方法,如无特别说明和限定,均按照本领域的常规手段进行实施。Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in this field and related fields without creative efforts should fall within the scope of protection of the present invention. The structures, devices and operating methods that are not specifically described and explained in the present invention are all implemented according to conventional means in the art unless otherwise specified or limited.
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