CN116801868A - 5-羟色氨酸胃滞留剂型 - Google Patents

5-羟色氨酸胃滞留剂型 Download PDF

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Publication number
CN116801868A
CN116801868A CN202280011205.2A CN202280011205A CN116801868A CN 116801868 A CN116801868 A CN 116801868A CN 202280011205 A CN202280011205 A CN 202280011205A CN 116801868 A CN116801868 A CN 116801868A
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CN
China
Prior art keywords
htp
carbidopa
dosage form
modified release
release layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280011205.2A
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English (en)
Chinese (zh)
Inventor
雅各布·帕德·拉姆索·雅各布森
布雷特·伯纳
林武
郑清琇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evesia Treatment Co
Original Assignee
Evesia Treatment Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evesia Treatment Co filed Critical Evesia Treatment Co
Publication of CN116801868A publication Critical patent/CN116801868A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202280011205.2A 2021-07-30 2022-07-29 5-羟色氨酸胃滞留剂型 Pending CN116801868A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163227915P 2021-07-30 2021-07-30
US63/227,915 2021-07-30
PCT/US2022/038914 WO2023009841A1 (en) 2021-07-30 2022-07-29 5-hydroxytryptophan gastroretentive dosage forms

Publications (1)

Publication Number Publication Date
CN116801868A true CN116801868A (zh) 2023-09-22

Family

ID=83049744

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280011205.2A Pending CN116801868A (zh) 2021-07-30 2022-07-29 5-羟色氨酸胃滞留剂型

Country Status (14)

Country Link
US (2) US11752107B2 (https=)
EP (1) EP4362919A1 (https=)
JP (1) JP2024528125A (https=)
KR (1) KR20240039030A (https=)
CN (1) CN116801868A (https=)
AU (1) AU2022320730A1 (https=)
BR (1) BR112024001927A2 (https=)
CA (1) CA3226223A1 (https=)
CL (1) CL2024000271A1 (https=)
CO (1) CO2024002256A2 (https=)
IL (1) IL310523A (https=)
MX (1) MX2024001390A (https=)
WO (1) WO2023009841A1 (https=)
ZA (1) ZA202401725B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12409163B2 (en) 2021-07-30 2025-09-09 Evecxia Therapeutics, Inc. Method of enhancing 5-hydroxytryptophan (5-HTP) exposure
US11779567B2 (en) 2021-10-14 2023-10-10 Evecxia Therapeutics, Inc. Method for optimizing 5-hydroxytryptamine function in the brain for therapeutic purposes
WO2024148354A1 (en) * 2023-01-06 2024-07-11 Evecxia Therapeutics, Inc. A method of enhancing 5-hydroxytryptophan (5-htp) exposure
WO2025042927A2 (en) * 2023-08-24 2025-02-27 Merck Sharp & Dohme Llc Sustained-release formulations for poorly permeable cyclic peptides

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WO1991007960A1 (fr) * 1989-11-24 1991-06-13 Paul Trouillas Compositions pharmaceutiques destinees au traitement de l'ataxie et les troubles de l'equilibre
CN1700908A (zh) * 2002-09-28 2005-11-23 麦克内尔-Ppc股份有限公司 具有两个核的改进释放剂型
WO2011151708A1 (en) * 2010-06-01 2011-12-08 Rubicon Research Private Limited Gastroretentive dosage forms of gaba analogs
WO2019245925A1 (en) * 2018-06-19 2019-12-26 National University Of Singapore Formulations of 5-hydroxy tryptophan (5-htp) for better bioavailability for various indications
WO2020014334A1 (en) * 2018-07-11 2020-01-16 Duke University Use of sustained-release 5-hydroxytryptophan in treating gastrointestinal disorders

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US4658038A (en) 1982-10-07 1987-04-14 Research Foundation For Mental Hygiene, Inc. N-acylated 5-hydroxytryptophan amide derivatives
IL87710A (en) 1987-09-18 1992-06-21 Ciba Geigy Ag Covered floating retard form for controlled release in gastric juice
IT1282650B1 (it) * 1996-02-19 1998-03-31 Jagotec Ag Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
CA2290624C (en) 1997-06-06 2006-12-05 John W. Shell Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs
US6635280B2 (en) 1997-06-06 2003-10-21 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
IN186245B (https=) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
EP1063973B1 (en) 1998-03-19 2016-11-16 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
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Patent Citations (6)

* Cited by examiner, † Cited by third party
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WO1991007960A1 (fr) * 1989-11-24 1991-06-13 Paul Trouillas Compositions pharmaceutiques destinees au traitement de l'ataxie et les troubles de l'equilibre
CN1700908A (zh) * 2002-09-28 2005-11-23 麦克内尔-Ppc股份有限公司 具有两个核的改进释放剂型
WO2011151708A1 (en) * 2010-06-01 2011-12-08 Rubicon Research Private Limited Gastroretentive dosage forms of gaba analogs
WO2019245925A1 (en) * 2018-06-19 2019-12-26 National University Of Singapore Formulations of 5-hydroxy tryptophan (5-htp) for better bioavailability for various indications
CN112469400A (zh) * 2018-06-19 2021-03-09 新加坡国立大学 对于各种适应症的生物利用度更佳的5-羟色氨酸(5-htp)制剂
WO2020014334A1 (en) * 2018-07-11 2020-01-16 Duke University Use of sustained-release 5-hydroxytryptophan in treating gastrointestinal disorders

Also Published As

Publication number Publication date
JP2024528125A (ja) 2024-07-26
BR112024001927A2 (pt) 2024-04-30
IL310523A (en) 2024-03-01
WO2023009841A1 (en) 2023-02-02
KR20240039030A (ko) 2024-03-26
CA3226223A1 (en) 2023-02-02
US11752107B2 (en) 2023-09-12
CL2024000271A1 (es) 2024-08-16
US20230047338A1 (en) 2023-02-16
US20240108582A1 (en) 2024-04-04
EP4362919A1 (en) 2024-05-08
CO2024002256A2 (es) 2024-03-18
ZA202401725B (en) 2025-08-27
AU2022320730A1 (en) 2024-03-14
MX2024001390A (es) 2024-05-17

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