CN116782901A - 用于使神经病理性疼痛缓和的药物 - Google Patents

用于使神经病理性疼痛缓和的药物 Download PDF

Info

Publication number
CN116782901A
CN116782901A CN202180080359.2A CN202180080359A CN116782901A CN 116782901 A CN116782901 A CN 116782901A CN 202180080359 A CN202180080359 A CN 202180080359A CN 116782901 A CN116782901 A CN 116782901A
Authority
CN
China
Prior art keywords
receptor
hydroxymethyl
tetrahydroquinoline
carboxamide
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180080359.2A
Other languages
English (en)
Chinese (zh)
Inventor
今井阳介
山本光
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Pharma Corp
Original Assignee
Asahi Kasei Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Pharma Corp filed Critical Asahi Kasei Pharma Corp
Publication of CN116782901A publication Critical patent/CN116782901A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202180080359.2A 2020-11-30 2021-11-26 用于使神经病理性疼痛缓和的药物 Pending CN116782901A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-199206 2020-11-30
JP2020199206 2020-11-30
PCT/JP2021/043375 WO2022114122A1 (ja) 2020-11-30 2021-11-26 神経障害性疼痛を緩和させるための医薬

Publications (1)

Publication Number Publication Date
CN116782901A true CN116782901A (zh) 2023-09-19

Family

ID=81755628

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180080359.2A Pending CN116782901A (zh) 2020-11-30 2021-11-26 用于使神经病理性疼痛缓和的药物

Country Status (11)

Country Link
US (1) US20240009180A1 (https=)
EP (1) EP4272758A4 (https=)
JP (1) JPWO2022114122A1 (https=)
KR (1) KR20230096055A (https=)
CN (1) CN116782901A (https=)
AU (1) AU2021389409A1 (https=)
CA (1) CA3198258A1 (https=)
IL (1) IL302972A (https=)
MX (1) MX2023006289A (https=)
TW (1) TW202237111A (https=)
WO (1) WO2022114122A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025261412A1 (zh) * 2024-06-18 2025-12-26 武汉人福创新药物研发中心有限公司 氨基酯类化合物及其作为p2x7拮抗剂的用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020514371A (ja) * 2017-03-13 2020-05-21 ラクオリア創薬株式会社 Ｐ２ｘ７受容体拮抗薬としてのテトラヒドロキノリン誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013269606B2 (en) 2012-06-01 2018-05-17 Ablynx N.V. P2X7 receptor antagonists and agonists
JP6301920B2 (ja) 2013-05-27 2018-03-28 国立大学法人 岡山大学 疼痛治療薬
EP3398941A1 (en) 2017-05-03 2018-11-07 AXXAM S.p.A. Heterocyclic p2x7 antagonists
JP7311944B2 (ja) 2018-04-16 2023-07-20 塩野義製薬株式会社 二環性含窒素複素環誘導体を含有する医薬組成物
JP2019182806A (ja) 2018-04-16 2019-10-24 塩野義製薬株式会社 二環性複素環誘導体およびそれらを含有する医薬組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020514371A (ja) * 2017-03-13 2020-05-21 ラクオリア創薬株式会社 Ｐ２ｘ７受容体拮抗薬としてのテトラヒドロキノリン誘導体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DANIEL URSU等: "Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain", 《MOL PAIN》, vol. 10, no. 37, 16 June 2014 (2014-06-16), pages 1 - 11 *
XU，LAN等: "The Mechanisms Underlying the Involvement of Spinal P2X7 Recep tor in Painful Diabetic Neuropathy", 《DIABETES》, vol. 66, 1 June 2017 (2017-06-01), pages 149 *
YAN-LU YING等: "Over-expression of P2X7 receptors in spinal glial cells contributes to the development of chronic postsurgical pain induced by skin/muscle incision and retraction (SMIR) in rats", 《EXP NEUROL》, vol. 261, 19 September 2014 (2014-09-19), pages 836 - 843, XP055934723, DOI: 10.1016/j.expneurol.2014.09.007 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025261412A1 (zh) * 2024-06-18 2025-12-26 武汉人福创新药物研发中心有限公司 氨基酯类化合物及其作为p2x7拮抗剂的用途

Also Published As

Publication number Publication date
WO2022114122A1 (ja) 2022-06-02
US20240009180A1 (en) 2024-01-11
KR20230096055A (ko) 2023-06-29
EP4272758A1 (en) 2023-11-08
EP4272758A4 (en) 2025-01-29
JPWO2022114122A1 (https=) 2022-06-02
CA3198258A1 (en) 2022-06-02
IL302972A (en) 2023-07-01
MX2023006289A (es) 2023-07-31
TW202237111A (zh) 2022-10-01
AU2021389409A1 (en) 2023-06-22

Similar Documents

Publication Publication Date Title
Lischka et al. Genetic pain loss disorders
Busse et al. Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients
EP3331551B1 (en) Compositions for use in treating neurodegenerative and neuroinflammatory conditions
EP3846810B1 (en) Chronic nightly dosing of lasmiditan for migraine prevention
US12253531B2 (en) Diagnostic or predictor of relapsing remitting multiple sclerosis
Medel et al. Coronary computed tomographic angiographic findings in asymptomatic patients with heterozygous familial hypercholesterolemia and null allele low-density lipoprotein receptor mutations
KR20210102294A (ko) 근위축성 측삭 경화증에서 치료요법적 중재를 안내하기 위한 신경필라멘트 단백질
KR20120050512A (ko) 탈수초를 갖는 환자에서 ４-아미노피리딘을 사용한 지속적 치료
CN116782901A (zh) 用于使神经病理性疼痛缓和的药物
Świtała et al. Genetic aspects of pain and its variability in the human population
JP4174203B2 (ja) 骨損傷の受け易さを判定する方法
US20210236594A1 (en) Methods for improving frailty and aging
Somerville et al. Adjunctive therapy of uncontrolled partial seizures with levetiracetam in Australian patients
US20250381197A1 (en) Regimen for Treating Amyotrophic Lateral Sclerosis Having Onset 24 Months Prior to Treatment
HK40094114A (en) Medicine for alleviating neuropathic pain
Kimura et al. H1-and H2-receptor antagonists prevent histamine release in allergic patients after the administration of midazolam-ketamine. A randomized controlled study
EP3860607B1 (en) Compound (8ar,12as,13as)-5,8,8a,9,10,11,12,12a,13,13a- decaidro-3-methoxy-12-(ethylsulphonyl)-6h- isochino [2,1-g] [1,6] naftiridine for use in the treatment of psychoses
Cazzato Clinical and genetic characterization of neuropathic pain through the model of small fiber neuropathy: Implication for diabetic neuropathy
Desimone ApoE4 and the Clinical Outcomes and Pathophysiology of Degenerative Cervical Myelopathy: Evidence from Human Data and Mouse Models
Ristic et al. The influence of the lesion in STN on clinical characteristics of the patients with hemiballism due to stroke
HK40045255B (en) Chronic nightly dosing of lasmiditan for migraine prevention
Benedetti et al. Long-term efficacy of Rituximab in anti-MAG polyneuropathy
Vondracek New Perspectives in the Treatment of Inherited

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20230919