CN116710107A - 用于治疗或预防SNCA相关的神经退化性疾病的SNCA iRNA组成物及其使用方法 - Google Patents

用于治疗或预防SNCA相关的神经退化性疾病的SNCA iRNA组成物及其使用方法 Download PDF

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Publication number
CN116710107A
CN116710107A CN202180081220.XA CN202180081220A CN116710107A CN 116710107 A CN116710107 A CN 116710107A CN 202180081220 A CN202180081220 A CN 202180081220A CN 116710107 A CN116710107 A CN 116710107A
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nucleotides
nucleotide
strand
dsrna agent
antisense strand
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Chinese (zh)
Inventor
M·M·桑达拉潘迪安
L·T·H·唐
J·D·麦金宁
M·K·施莱格尔
A·卡斯托雷诺
C·凯特坦尼斯
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Anila Pharmaceuticals
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Anila Pharmaceuticals
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN202180081220.XA 2020-10-01 2021-09-29 用于治疗或预防SNCA相关的神经退化性疾病的SNCA iRNA组成物及其使用方法 Pending CN116710107A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063086495P 2020-10-01 2020-10-01
US63/086,495 2020-10-01
PCT/US2021/052580 WO2022072447A1 (en) 2020-10-01 2021-09-29 Snca irna compositions and methods of use thereof for treating or preventing snca-associated neurodegenerative diseases

Publications (1)

Publication Number Publication Date
CN116710107A true CN116710107A (zh) 2023-09-05

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CN202180081220.XA Pending CN116710107A (zh) 2020-10-01 2021-09-29 用于治疗或预防SNCA相关的神经退化性疾病的SNCA iRNA组成物及其使用方法

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Country Link
US (1) US20240011032A1 (https=)
EP (1) EP4221838A4 (https=)
JP (1) JP2023544385A (https=)
KR (1) KR20230079405A (https=)
CN (1) CN116710107A (https=)
AR (1) AR123679A1 (https=)
AU (1) AU2021353935A1 (https=)
CA (1) CA3193830A1 (https=)
IL (1) IL301712A (https=)
MX (1) MX2023003810A (https=)
TW (1) TW202229551A (https=)
WO (1) WO2022072447A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119630791A (zh) * 2022-05-13 2025-03-14 迪克纳制药公司 用于抑制snca表达的组合物和方法
US20260103703A1 (en) * 2022-09-29 2026-04-16 Atalanta Therapeutics, Inc. siRNA COMPOSITIONS AND METHODS TARGETING ALPHA-SYNUCLEIN NUCLEIC ACIDS
WO2024166019A1 (en) * 2023-02-08 2024-08-15 Biorchestra Co., Ltd. Sirna targeting alpha-synuclein and uses thereof
AU2024335806A1 (en) * 2023-09-07 2026-04-23 Janssen Pharmaceutica Nv SNCA siRNA AND USES THEREOF
WO2025162214A1 (en) * 2024-01-30 2025-08-07 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of synuclein alpha (snca) gene
TW202547527A (zh) * 2024-02-08 2025-12-16 日商泰爾茂股份有限公司 寡核苷酸

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006006948A2 (en) * 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
EP2508608A1 (en) * 2003-06-09 2012-10-10 Alnylam Pharmaceuticals Inc. Method of treating neurodegenerative disease
WO2005045034A2 (en) * 2003-10-23 2005-05-19 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED TREATMENT OF PARKINSON DISEASE USING SHORT INTERERING NUCLEIC ACID (siNA)
US20080003570A1 (en) * 2004-12-22 2008-01-03 The General Hospital Corporation Translation enhancer elements of genes encoding human Tau protein and human alpha-synuclein protein
US20100105134A1 (en) * 2007-03-02 2010-04-29 Mdrna, Inc. Nucleic acid compounds for inhibiting gene expression and uses thereof
WO2009079399A2 (en) * 2007-12-14 2009-06-25 Alnylam Pharmaceuticals, Inc. Method of treating neurodegenerative disease
WO2012027713A2 (en) * 2010-08-26 2012-03-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibition of snca
CA3077910A1 (en) * 2010-11-17 2012-05-24 Ionis Pharmaceuticals, Inc. Modulation of alpha synuclein expression
CN108728533B (zh) * 2017-04-20 2022-06-14 常青 用于髓母细胞瘤分子分型的基因群以及snca基因作为4型髓母细胞瘤的生物标志物的用途
AU2019207859A1 (en) * 2018-01-12 2020-07-02 Roche Innovation Center Copenhagen A/S Alpha-synuclein antisense oligonucleotides and uses thereof
WO2019217459A1 (en) * 2018-05-07 2019-11-14 Alnylam Pharmaceuticals, Inc. Extrahepatic delivery
EP3830265A1 (en) * 2018-08-03 2021-06-09 Genzyme Corporation Variant rnai against alpha-synuclein

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Publication number Publication date
JP2023544385A (ja) 2023-10-23
TW202229551A (zh) 2022-08-01
CA3193830A1 (en) 2022-04-07
KR20230079405A (ko) 2023-06-07
AU2021353935A1 (en) 2023-05-25
WO2022072447A1 (en) 2022-04-07
AR123679A1 (es) 2023-01-04
EP4221838A1 (en) 2023-08-09
MX2023003810A (es) 2023-06-12
US20240011032A1 (en) 2024-01-11
EP4221838A4 (en) 2025-04-16
IL301712A (en) 2023-05-01

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